Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot2 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions

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Resource Profile: ComparativeEvidence

Profile of Evidence for Evidence Based Medicine IG. The ComparativeEvidence Profile is used for evidence with a measured variable that is considered the outcome of an exposure or intervention, and an exposure variable with two or more categories that are being compared.

Usages:

• Derived from this Profile: ComparativeBaselineMeasureEvidence, ComparativeParticipantFlowEvidence and NetEffectContribution
• Refer to this Profile: BaselineMeasureReport, OutcomeMeasureReport, SummaryOfFindings and SummaryOfNetEffect
• Examples for this Profile: ComparativeEvidence_Bypass_surgery_effects_on_Myocardial_infarction_or_stroke_in_Swedish_Obese_Subjects_SOS_study, ComparativeEvidence_Bypass_surgery_effects_on_Remission_of_diabetes_in_JAMA_2018_Norwegian_cohort_study, ComparativeEvidence_Bypass_surgery_effects_on_New_onset_depression_in_JAMA_2018_Norwegian_cohort_study, ComparativeEvidence_Bypass_surgery_effects_on_Treatment_with_opioids_in_JAMA_2018_Norwegian_cohort_study... Show 46 more, ComparativeEvidence_Bypass_surgery_effects_on_Additional_GI_surgical_procedure_in_JAMA_2018_Norwegian_cohort_study, All_cause_mortality_from_MAGICapp_313876, Cardiovascular_mortality_from_MAGICapp_313877, End_stage_kidney_disease_from_MAGICapp_313880, Heart_failure_from_MAGICapp_313881, Health_related_quality_of_life_from_MAGICapp_109569, Body_weight_from_MAGICapp_109570, All_cause_mortality_from_MAGICapp_313956, Cardiovascular_mortality_from_MAGICapp_313957, End_stage_kidney_disease_from_MAGICapp_313960, Heart_failure_from_MAGICapp_313961, Diabetic_ketoacidosis_from_MAGICapp_313962, Genital_infection_from_MAGICapp_313964, Health_related_quality_of_life_from_MAGICapp_109587, Body_weight_from_MAGICapp_109588, Injury_Severity_Score_on_Impact_comparing_intervention_vs_comparator, Death_or_Major_Traumatic_Injury_on_Impact_comparing_intervention_vs_comparator, Death_or_Major_Traumatic_Injury_30_days_after_Impact_comparing_intervention_vs_comparator, Injury_Severity_Score_30_days_after_Impact_comparing_intervention_vs_comparator, Health_Survey_Score_Total_comparing_intervention_vs_comparator, Health_Survey_Score_Physical_Health_Subscore_comparing_intervention_vs_comparator, Health_Survey_Score_Mental_Health_Subscore_comparing_intervention_vs_comparator, ComparativeEvidence_Bariatric_Surgery_effect_for_ADA_triple_outcome_at_5_years_Diabetes_Surgery_Study, MeanDiffA1c2016metaAnalysis, NCT03640312_primaryOutcomeMeasure_0_OutcomeAnalysis_0_BetweenGroupAnalysis_OG000_OG001, NCT03640312_secondaryOutcomeMeasure_1_OutcomeAnalysis_2_BetweenGroupAnalysis_OG000_OG001, NCT03640312_secondaryOutcomeMeasure_7_OutcomeAnalysis_8_BetweenGroupAnalysis_OG000_OG001, NCT03640312_secondaryOutcomeMeasure_7_OutcomeAnalysis_9_BetweenGroupAnalysis_OG000_OG001, NCT03640312_secondaryOutcomeMeasure_8_OutcomeAnalysis_10_BetweenGroupAnalysis_OG000_OG001, Evidence_for_Results_for_Systolic_blood_pressure_at_12_weeks_in_GroupAssignment_Quadpill_vs_Candesartan, ComparativeEvidence_Mean_difference_in_HbA1c_between_Surgery_and_Medical_Lifestyle_groups_in_Mingrone_2012_DIBASY_trial, ComparativeEvidence_Mean_difference_in_HbA1c_between_Surgery_and_Medical_Lifestyle_groups_in_Mingrone_2015_DIBASY_trial, ComparativeEvidence_Mean_difference_in_HbA1c_between_Surgery_and_Medical_Lifestyle_groups_in_Parikh_2014, ComparativeEvidence_Mean_difference_in_HbA1c_between_Surgery_and_Medical_Lifestyle_groups_in_Courcoulas_2014, ComparativeEvidence_Mean_difference_in_HbA1c_between_Surgery_and_Medical_Lifestyle_groups_in_Ding_2015, ComparativeEvidence_Mean_difference_in_HbA1c_between_Surgery_and_Medical_Lifestyle_groups_in_Halperin_2014, ComparativeEvidence_Mean_difference_in_HbA1c_between_Surgery_and_Medical_Lifestyle_groups_in_Ikramuddin_2013, ComparativeEvidence_Mean_difference_in_HbA1c_between_Surgery_and_Medical_Lifestyle_groups_in_Liang_2013, ComparativeEvidence_Mean_difference_in_HbA1c_between_Surgery_and_Medical_Lifestyle_groups_in_Schauer_2012_STAMPEDE_trial, ComparativeEvidence_Mean_difference_in_HbA1c_between_Surgery_and_Medical_Lifestyle_groups_in_Cummings_2016, ComparativeEvidence_Mean_difference_in_HbA1c_between_Surgery_and_Medical_Lifestyle_groups_in_Dixon_2008, ComparativeEvidence_Mean_difference_in_HbA1c_between_Surgery_and_Medical_Lifestyle_groups_in_Ikramuddin_2015, ComparativeEvidence_Mean_difference_in_HbA1c_between_Surgery_and_Medical_Lifestyle_groups_in_Wentworth_2014, ComparativeEvidence_Mean_difference_in_HbA1c_between_Surgery_and_Medical_Lifestyle_groups_in_Courcoulas_2015, ComparativeEvidence_Mean_difference_in_HbA1c_between_Surgery_and_Medical_Lifestyle_groups_in_Schauer_2014_STAMPEDE_trial and AllCauseMortality2022metaAnalysis

You can also check for usages in the FHIR IG Statistics

Formal Views of Profile Content

Description of Profiles, Differentials, Snapshots and how the different presentations work.

• Key Elements Table
• Differential Table
• Snapshot Table
• Statistics/References
• All

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
Evidence	C	0..*	Evidence	Single evidence bit Constraints: cnl-0
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
contained		0..*	Resource	Contained, inline Resources
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:RelatesToWithQuotation		0..*	(Complex)	Related artifact with quoted portion URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/relates-to-with-quotation
extension:publicationStatus		0..1	CodeableConcept	Publication status URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/artifact-publication-status Binding: Cited Artifact Status Type (preferred)
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored
status	?!Σ	1..1	code	draft | active | retired | unknown Binding: PublicationStatus (required): The lifecycle status of an artifact.
Slices for variableDefinition		3..*	BackboneElement	Description, classification, and definition of a single variable Slice: Unordered, Open by value:variableRole
variableDefinition:All Slices				Content/Rules for all slices
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
variableRole	Σ	1..1	code	population | exposure | outcome | covariate Binding: EvidenceVariableRole (required): The role that the variable plays.
variableDefinition:population		1..*	BackboneElement	Description, classification, and definition of a single variable
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
variableRole	Σ	1..1	code	population | exposure | outcome | covariate Binding: EvidenceVariableRole (required): The role that the variable plays. Required Pattern: population
observed	Σ	0..1	Reference(StudyGroup | ExposureGroup | ComparatorGroup | MetaanalysisStudyGroup)	Definition of the actual variable related to the statistic(s)
intended		0..1	Reference(Group)	Definition of the intended variable related to the Evidence
variableDefinition:exposure		1..1	BackboneElement	Description, classification, and definition of a single variable
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
variableRole	Σ	1..1	code	population | exposure | outcome | covariate Binding: EvidenceVariableRole (required): The role that the variable plays. Required Pattern: exposure
comparatorCategory		1..1	string	The reference value used for comparison
observed	Σ	0..1	Reference(GroupAssignment)	Definition of the actual variable related to the statistic(s)
intended		0..1	Reference(VariableDefinition)	Definition of the intended variable related to the Evidence
variableDefinition:outcome	S	1..*	BackboneElement	Description, classification, and definition of a single variable
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
variableRole	Σ	1..1	code	population | exposure | outcome | covariate Binding: EvidenceVariableRole (required): The role that the variable plays. Required Pattern: outcome
observed	Σ	0..1	Reference(VariableDefinition)	Definition of the actual variable related to the statistic(s)
intended		0..1	Reference(EvidenceVariable)	Definition of the intended variable related to the Evidence
Documentation for this format

Terminology Bindings

Path	Conformance	ValueSet / Code	URI
Evidence.status	required	PublicationStatus http://hl7.org/fhir/ValueSet/publication-status|6.0.0-ballot3 From the FHIR Standard
Evidence.variableDefinition.variableRole	required	EvidenceVariableRole http://hl7.org/fhir/ValueSet/variable-role|6.0.0-ballot3 From the FHIR Standard
Evidence.variableDefinition:population.variableRole	required	Pattern Value: population http://hl7.org/fhir/ValueSet/variable-role|6.0.0-ballot3 From the FHIR Standard
Evidence.variableDefinition:exposure.variableRole	required	Pattern Value: exposure http://hl7.org/fhir/ValueSet/variable-role|6.0.0-ballot3 From the FHIR Standard
Evidence.variableDefinition:outcome.variableRole	required	Pattern Value: outcome http://hl7.org/fhir/ValueSet/variable-role|6.0.0-ballot3 From the FHIR Standard

Constraints

Id	Grade	Path(s)	Details	Requirements
cnl-0	warning	Evidence	Name should be usable as an identifier for the module by machine processing applications such as code generation : name.exists() implies name.matches('^[A-Z]([A-Za-z0-9_]){1,254}$')
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children : hasValue() or (children().count() > id.count())
ext-1	error	**ALL** extensions	Must have either extensions or value[x], not both : extension.exists() != value.exists()

This structure is derived from Evidence

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
Evidence			Evidence
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:RelatesToWithQuotation		0..*	(Complex)	Related artifact with quoted portion URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/relates-to-with-quotation
extension:publicationStatus		0..1	CodeableConcept	Publication status URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/artifact-publication-status Binding: Cited Artifact Status Type (preferred)
Slices for variableDefinition		3..*	BackboneElement	Description, classification, and definition of a single variable Slice: Unordered, Open by value:variableRole
variableDefinition:population		1..*	BackboneElement	Description, classification, and definition of a single variable
variableRole		1..1	code	population | exposure | outcome | covariate Required Pattern: population
observed		0..1	Reference(StudyGroup | ExposureGroup | ComparatorGroup | MetaanalysisStudyGroup)	Definition of the actual variable related to the statistic(s)
intended		0..1	Reference(Group)	Definition of the intended variable related to the Evidence
variableDefinition:exposure		1..1	BackboneElement	Description, classification, and definition of a single variable
variableRole		1..1	code	population | exposure | outcome | covariate Required Pattern: exposure
comparatorCategory		1..1	string	The reference value used for comparison
observed		0..1	Reference(GroupAssignment)	Definition of the actual variable related to the statistic(s)
intended		0..1	Reference(VariableDefinition)	Definition of the intended variable related to the Evidence
variableDefinition:outcome	S	1..*	BackboneElement	Description, classification, and definition of a single variable
variableRole		1..1	code	population | exposure | outcome | covariate Required Pattern: outcome
comparatorCategory		0..0
observed		0..1	Reference(VariableDefinition)	Definition of the actual variable related to the statistic(s)
intended		0..1	Reference(EvidenceVariable)	Definition of the intended variable related to the Evidence
Documentation for this format

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
Evidence	C	0..*	Evidence	Single evidence bit Constraints: cnl-0
id	Σ	0..1	id	Logical id of this artifact
meta	Σ	0..1	Meta	Metadata about the resource
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
language		0..1	code	Language of the resource content Binding: AllLanguages (required): IETF language tag for a human language Additional Bindings Purpose CommonLanguages Starter
text		0..1	Narrative	Text summary of the resource, for human interpretation This profile does not constrain the narrative in regard to content, language, or traceability to data elements
contained		0..*	Resource	Contained, inline Resources
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:RelatesToWithQuotation		0..*	(Complex)	Related artifact with quoted portion URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/relates-to-with-quotation
extension:publicationStatus		0..1	CodeableConcept	Publication status URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/artifact-publication-status Binding: Cited Artifact Status Type (preferred)
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored
url	ΣC	0..1	uri	Canonical identifier for this evidence, represented as a globally unique URI Constraints: cnl-1
identifier	Σ	0..*	Identifier	Additional identifier for the summary
version	Σ	0..1	string	Business version of this summary
versionAlgorithm[x]	Σ	0..1		How to compare versions Binding: VersionAlgorithm (extensible)
versionAlgorithmString			string
versionAlgorithmCoding			Coding
name	C	0..1	string	Name for this summary (machine friendly)
title	Σ	0..1	string	Name for this summary (human friendly)
citeAs		0..1	markdown	Display of how to cite this Evidence
status	?!Σ	1..1	code	draft | active | retired | unknown Binding: PublicationStatus (required): The lifecycle status of an artifact.
experimental		0..1	boolean	For testing only - never for real usage
date	Σ	0..1	dateTime	Date last changed
approvalDate		0..1	date	When the summary was approved by publisher
lastReviewDate		0..1	date	When the summary was last reviewed by the publisher
author	Σ	0..*	ContactDetail	Who authored the content
publisher	Σ	0..1	string	Name of the publisher/steward (organization or individual)
contact	Σ	0..*	ContactDetail	Contact details for the publisher
recorder		0..*	ContactDetail	Who entered the data for the evidence
editor		0..*	ContactDetail	Who edited the content
reviewer		0..*	ContactDetail	Who reviewed the content
endorser		0..*	ContactDetail	Who endorsed the content
useContext	Σ	0..*	UsageContext	The context that the content is intended to support
purpose		0..1	markdown	Why this Evidence is defined
copyright		0..1	markdown	Intellectual property ownership, may include restrictions on use
copyrightLabel		0..1	string	Copyright holder and year(s)
relatesTo		0..*	BackboneElement	Relationships to other Resources
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
type		1..1	code	documentation | justification | predecessor | successor | derived-from | depends-on | composed-of | part-of | amends | amended-with | appends | appended-with | cites | cited-by | comments-on | comment-in | contains | contained-in | corrects | correction-in | replaces | replaced-with | retracts | retracted-by | signs | similar-to | supports | supported-with | transforms | transformed-into | transformed-with | specification-of | created-with | cite-as | summarizes Binding: ArtifactRelationshipType (required): The type of relationship to the related artifact.
target[x]		1..1		The artifact that is related to this Evidence
targetUri			uri
targetAttachment			Attachment
targetCanonical			canonical(Resource)
targetReference			Reference(Resource)
targetMarkdown			markdown
description	Σ	0..1	markdown	Description of the particular summary
assertion		0..1	markdown	Declarative description of the Evidence
note		0..*	Annotation	Footnotes and/or explanatory notes
Slices for variableDefinition		3..*	BackboneElement	Description, classification, and definition of a single variable Slice: Unordered, Open by value:variableRole
variableDefinition:All Slices				Content/Rules for all slices
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	A text description or summary of the variable
note		0..*	Annotation	Footnotes and/or explanatory notes
variableRole	Σ	1..1	code	population | exposure | outcome | covariate Binding: EvidenceVariableRole (required): The role that the variable plays.
roleSubtype		0..1	CodeableConcept	Sub-classification of the role of the variable Binding: EvidenceVariableRoleSubtype (extensible): The sub-role that the variable plays.
comparatorCategory		0..1	string	The reference value used for comparison
observed	Σ	0..1	Reference(Group | EvidenceVariable)	Definition of the actual variable related to the statistic(s)
intended		0..1	Reference(Group | EvidenceVariable)	Definition of the intended variable related to the Evidence
directnessMatch		0..1	CodeableConcept	low | moderate | high | exact Binding: EvidenceDirectness (extensible): The quality of how direct the match is.
variableDefinition:population		1..*	BackboneElement	Description, classification, and definition of a single variable
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	A text description or summary of the variable
note		0..*	Annotation	Footnotes and/or explanatory notes
variableRole	Σ	1..1	code	population | exposure | outcome | covariate Binding: EvidenceVariableRole (required): The role that the variable plays. Required Pattern: population
roleSubtype		0..1	CodeableConcept	Sub-classification of the role of the variable Binding: EvidenceVariableRoleSubtype (extensible): The sub-role that the variable plays.
comparatorCategory		0..1	string	The reference value used for comparison
observed	Σ	0..1	Reference(StudyGroup | ExposureGroup | ComparatorGroup | MetaanalysisStudyGroup)	Definition of the actual variable related to the statistic(s)
intended		0..1	Reference(Group)	Definition of the intended variable related to the Evidence
directnessMatch		0..1	CodeableConcept	low | moderate | high | exact Binding: EvidenceDirectness (extensible): The quality of how direct the match is.
variableDefinition:exposure		1..1	BackboneElement	Description, classification, and definition of a single variable
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	A text description or summary of the variable
note		0..*	Annotation	Footnotes and/or explanatory notes
variableRole	Σ	1..1	code	population | exposure | outcome | covariate Binding: EvidenceVariableRole (required): The role that the variable plays. Required Pattern: exposure
roleSubtype		0..1	CodeableConcept	Sub-classification of the role of the variable Binding: EvidenceVariableRoleSubtype (extensible): The sub-role that the variable plays.
comparatorCategory		1..1	string	The reference value used for comparison
observed	Σ	0..1	Reference(GroupAssignment)	Definition of the actual variable related to the statistic(s)
intended		0..1	Reference(VariableDefinition)	Definition of the intended variable related to the Evidence
directnessMatch		0..1	CodeableConcept	low | moderate | high | exact Binding: EvidenceDirectness (extensible): The quality of how direct the match is.
variableDefinition:outcome	S	1..*	BackboneElement	Description, classification, and definition of a single variable
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	A text description or summary of the variable
note		0..*	Annotation	Footnotes and/or explanatory notes
variableRole	Σ	1..1	code	population | exposure | outcome | covariate Binding: EvidenceVariableRole (required): The role that the variable plays. Required Pattern: outcome
roleSubtype		0..1	CodeableConcept	Sub-classification of the role of the variable Binding: EvidenceVariableRoleSubtype (extensible): The sub-role that the variable plays.
observed	Σ	0..1	Reference(VariableDefinition)	Definition of the actual variable related to the statistic(s)
intended		0..1	Reference(EvidenceVariable)	Definition of the intended variable related to the Evidence
directnessMatch		0..1	CodeableConcept	low | moderate | high | exact Binding: EvidenceDirectness (extensible): The quality of how direct the match is.
synthesisType		0..*	CodeableConcept	The design of the synthesis (combination of studies) that produced this evidence Binding: StatisticSynthesisType (extensible): Types of combining results from a body of evidence (e.g. summary data meta-analysis).
studyDesign		0..*	CodeableConcept	The design of the study that produced this evidence Binding: StudyDesign (extensible): This is a set of terms for study design characteristics.
statistic		0..*	BackboneElement	Values and parameters for a single statistic
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	A natural language summary of the statistic
note		0..*	Annotation	Footnotes and/or explanatory notes
statisticType	Σ	0..1	CodeableConcept	Type of statistic, e.g., relative risk Binding: StatisticType (extensible)
category		0..1	CodeableConcept	Associated category for categorical variable
quantity	Σ	0..1	Quantity	Statistic value
numberOfEvents		0..1	unsignedInt	The number of events associated with the statistic
numberAffected		0..1	unsignedInt	The number of participants affected
sampleSize		0..1	BackboneElement	Count of participants in the study sample
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	Textual description of sample size for statistic
note		0..*	Annotation	Footnote or explanatory note about the sample size
numberOfStudies		0..1	unsignedInt	Number of contributing studies
numberOfParticipants		0..1	unsignedInt	Total number of participants
knownDataCount		0..1	unsignedInt	Number of participants with known results for measured variables
attributeEstimate		0..*	BackboneElement	An attribute of the Statistic
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	Textual description of the attribute estimate
note		0..*	Annotation	Footnote or explanatory note about the estimate
type		0..1	CodeableConcept	The type of attribute estimate, e.g., confidence interval or p value Binding: AttributeEstimateType (extensible)
quantity		0..1	Quantity	The singular quantity of the attribute estimate, for attribute estimates represented as single values, which may include a unit of measure
level		0..1	decimal	Level of confidence interval, e.g., 0.95 for 95% confidence interval
range		0..1	Range	Lower and upper bound values of the attribute estimate
attributeEstimate		0..*	See attributeEstimate (Evidence)	A nested attribute estimate; which is the attribute estimate of an attribute estimate
modelCharacteristic		0..*	BackboneElement	An aspect of the statistical model
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
code		1..1	CodeableConcept	Model specification Binding: StatisticModelCode (extensible)
value[x]		0..1		The specific value (when paired with code)
valueQuantity			Quantity(SimpleQuantity)
valueRange			Range
valueCodeableConcept			CodeableConcept
intended		0..1	boolean	The plan for analysis
applied		0..1	boolean	This model characteristic is part of the analysis that was applied, whether or not the analysis followed the plan
variable		0..*	BackboneElement	A variable adjusted for in the adjusted analysis
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
variableDefinition		1..1	Reference(Group | EvidenceVariable)	Description and definition of the variable
handling		0..1	code	boolean | continuous | dichotomous | ordinal | polychotomous | extension Binding: EvidenceVariableHandling (required)
valueCategory		0..*	CodeableConcept	Qualitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable
valueQuantity		0..*	Quantity	Quantitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable
valueRange		0..*	Range	Range of quantitative labels used for grouping values of a dichotomous, ordinal, or polychotomous variable
attribute		0..*	See attributeEstimate (Evidence)	An attribute of the model characteristic
certainty		0..*	BackboneElement	Certainty or quality of the evidence
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	Textual description of certainty
note		0..*	Annotation	Footnotes and/or explanatory notes
type		0..1	CodeableConcept	Aspect of certainty being rated Binding: EvidenceCertaintyType (extensible): The aspect of quality, confidence, or certainty.
rating		0..1	CodeableConcept	Assessment or judgement of the aspect Binding: EvidenceCertaintyRating (extensible): The assessment of quality, confidence, or certainty.
rater		0..*	string	Individual or group who did the rating
subcomponent		0..*	See certainty (Evidence)	A domain or subdomain of certainty
Documentation for this format

Terminology Bindings

Path	Conformance	ValueSet / Code	URI
Evidence.language	required	AllLanguages http://hl7.org/fhir/ValueSet/all-languages|6.0.0-ballot3 From the FHIR Standard
Evidence.versionAlgorithm[x]	extensible	VersionAlgorithm http://hl7.org/fhir/ValueSet/version-algorithm From the FHIR Standard
Evidence.status	required	PublicationStatus http://hl7.org/fhir/ValueSet/publication-status|6.0.0-ballot3 From the FHIR Standard
Evidence.relatesTo.type	required	ArtifactRelationshipType http://hl7.org/fhir/ValueSet/artifact-relationship-type|6.0.0-ballot3 From the FHIR Standard
Evidence.variableDefinition.variableRole	required	EvidenceVariableRole http://hl7.org/fhir/ValueSet/variable-role|6.0.0-ballot3 From the FHIR Standard
Evidence.variableDefinition.roleSubtype	extensible	EvidenceVariableRoleSubtype http://hl7.org/fhir/ValueSet/variable-role-subtype From the FHIR Standard
Evidence.variableDefinition.directnessMatch	extensible	EvidenceDirectness http://terminology.hl7.org/ValueSet/directness
Evidence.variableDefinition:population.variableRole	required	Pattern Value: population http://hl7.org/fhir/ValueSet/variable-role|6.0.0-ballot3 From the FHIR Standard
Evidence.variableDefinition:population.roleSubtype	extensible	EvidenceVariableRoleSubtype http://hl7.org/fhir/ValueSet/variable-role-subtype From the FHIR Standard
Evidence.variableDefinition:population.directnessMatch	extensible	EvidenceDirectness http://terminology.hl7.org/ValueSet/directness
Evidence.variableDefinition:exposure.variableRole	required	Pattern Value: exposure http://hl7.org/fhir/ValueSet/variable-role|6.0.0-ballot3 From the FHIR Standard
Evidence.variableDefinition:exposure.roleSubtype	extensible	EvidenceVariableRoleSubtype http://hl7.org/fhir/ValueSet/variable-role-subtype From the FHIR Standard
Evidence.variableDefinition:exposure.directnessMatch	extensible	EvidenceDirectness http://terminology.hl7.org/ValueSet/directness
Evidence.variableDefinition:outcome.variableRole	required	Pattern Value: outcome http://hl7.org/fhir/ValueSet/variable-role|6.0.0-ballot3 From the FHIR Standard
Evidence.variableDefinition:outcome.roleSubtype	extensible	EvidenceVariableRoleSubtype http://hl7.org/fhir/ValueSet/variable-role-subtype From the FHIR Standard
Evidence.variableDefinition:outcome.directnessMatch	extensible	EvidenceDirectness http://terminology.hl7.org/ValueSet/directness
Evidence.synthesisType	extensible	StatisticSynthesisType http://terminology.hl7.org/ValueSet/synthesis-type
Evidence.studyDesign	extensible	StudyDesign http://hl7.org/fhir/ValueSet/study-design From the FHIR Standard
Evidence.statistic.statisticType	extensible	StatisticType http://hl7.org/fhir/ValueSet/statistic-type From the FHIR Standard
Evidence.statistic.attributeEstimate.type	extensible	AttributeEstimateType http://hl7.org/fhir/ValueSet/attribute-estimate-type From the FHIR Standard
Evidence.statistic.modelCharacteristic.code	extensible	StatisticModelCode http://hl7.org/fhir/ValueSet/statistic-model-code From the FHIR Standard
Evidence.statistic.modelCharacteristic.variable.handling	required	EvidenceVariableHandling http://hl7.org/fhir/ValueSet/variable-handling|6.0.0-ballot3 From the FHIR Standard
Evidence.certainty.type	extensible	EvidenceCertaintyType http://hl7.org/fhir/ValueSet/certainty-type From the FHIR Standard
Evidence.certainty.rating	extensible	EvidenceCertaintyRating http://hl7.org/fhir/ValueSet/certainty-rating From the FHIR Standard

Constraints

Id	Grade	Path(s)	Details	Requirements
cnl-0	warning	Evidence	Name should be usable as an identifier for the module by machine processing applications such as code generation : name.exists() implies name.matches('^[A-Z]([A-Za-z0-9_]){1,254}$')
cnl-1	warning	Evidence.url	URL should not contain | or # - these characters make processing canonical references problematic : exists() implies matches('^[^|# ]+$')
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children : hasValue() or (children().count() > id.count())
ext-1	error	**ALL** extensions	Must have either extensions or value[x], not both : extension.exists() != value.exists()

This structure is derived from Evidence

Summary

Mandatory: 4 elements
Must-Support: 1 element
Prohibited: 1 element

Structures

This structure refers to these other structures:

• StudyGroup (http://hl7.org/fhir/uv/ebm/StructureDefinition/study-group)
• ExposureGroup (http://hl7.org/fhir/uv/ebm/StructureDefinition/exposure-group)
• ComparatorGroup (http://hl7.org/fhir/uv/ebm/StructureDefinition/comparator-group)
• MetaanalysisStudyGroup (http://hl7.org/fhir/uv/ebm/StructureDefinition/metaanalysis-study-group)
• GroupAssignment (http://hl7.org/fhir/uv/ebm/StructureDefinition/group-assignment)
• VariableDefinition (http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition)

Extensions

This structure refers to these extensions:

• http://hl7.org/fhir/uv/ebm/StructureDefinition/relates-to-with-quotation
• http://hl7.org/fhir/uv/ebm/StructureDefinition/artifact-publication-status

Slices

This structure defines the following Slices:

• The element 1 is sliced based on the value of Evidence.variableDefinition

Maturity: 1

Key Elements View

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
Evidence	C	0..*	Evidence	Single evidence bit Constraints: cnl-0
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
contained		0..*	Resource	Contained, inline Resources
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:RelatesToWithQuotation		0..*	(Complex)	Related artifact with quoted portion URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/relates-to-with-quotation
extension:publicationStatus		0..1	CodeableConcept	Publication status URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/artifact-publication-status Binding: Cited Artifact Status Type (preferred)
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored
status	?!Σ	1..1	code	draft | active | retired | unknown Binding: PublicationStatus (required): The lifecycle status of an artifact.
Slices for variableDefinition		3..*	BackboneElement	Description, classification, and definition of a single variable Slice: Unordered, Open by value:variableRole
variableDefinition:All Slices				Content/Rules for all slices
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
variableRole	Σ	1..1	code	population | exposure | outcome | covariate Binding: EvidenceVariableRole (required): The role that the variable plays.
variableDefinition:population		1..*	BackboneElement	Description, classification, and definition of a single variable
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
variableRole	Σ	1..1	code	population | exposure | outcome | covariate Binding: EvidenceVariableRole (required): The role that the variable plays. Required Pattern: population
observed	Σ	0..1	Reference(StudyGroup | ExposureGroup | ComparatorGroup | MetaanalysisStudyGroup)	Definition of the actual variable related to the statistic(s)
intended		0..1	Reference(Group)	Definition of the intended variable related to the Evidence
variableDefinition:exposure		1..1	BackboneElement	Description, classification, and definition of a single variable
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
variableRole	Σ	1..1	code	population | exposure | outcome | covariate Binding: EvidenceVariableRole (required): The role that the variable plays. Required Pattern: exposure
comparatorCategory		1..1	string	The reference value used for comparison
observed	Σ	0..1	Reference(GroupAssignment)	Definition of the actual variable related to the statistic(s)
intended		0..1	Reference(VariableDefinition)	Definition of the intended variable related to the Evidence
variableDefinition:outcome	S	1..*	BackboneElement	Description, classification, and definition of a single variable
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
variableRole	Σ	1..1	code	population | exposure | outcome | covariate Binding: EvidenceVariableRole (required): The role that the variable plays. Required Pattern: outcome
observed	Σ	0..1	Reference(VariableDefinition)	Definition of the actual variable related to the statistic(s)
intended		0..1	Reference(EvidenceVariable)	Definition of the intended variable related to the Evidence
Documentation for this format

Terminology Bindings

Path	Conformance	ValueSet / Code	URI
Evidence.status	required	PublicationStatus http://hl7.org/fhir/ValueSet/publication-status|6.0.0-ballot3 From the FHIR Standard
Evidence.variableDefinition.variableRole	required	EvidenceVariableRole http://hl7.org/fhir/ValueSet/variable-role|6.0.0-ballot3 From the FHIR Standard
Evidence.variableDefinition:population.variableRole	required	Pattern Value: population http://hl7.org/fhir/ValueSet/variable-role|6.0.0-ballot3 From the FHIR Standard
Evidence.variableDefinition:exposure.variableRole	required	Pattern Value: exposure http://hl7.org/fhir/ValueSet/variable-role|6.0.0-ballot3 From the FHIR Standard
Evidence.variableDefinition:outcome.variableRole	required	Pattern Value: outcome http://hl7.org/fhir/ValueSet/variable-role|6.0.0-ballot3 From the FHIR Standard

Constraints

Id	Grade	Path(s)	Details	Requirements
cnl-0	warning	Evidence	Name should be usable as an identifier for the module by machine processing applications such as code generation : name.exists() implies name.matches('^[A-Z]([A-Za-z0-9_]){1,254}$')
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children : hasValue() or (children().count() > id.count())
ext-1	error	**ALL** extensions	Must have either extensions or value[x], not both : extension.exists() != value.exists()

Differential View

This structure is derived from Evidence

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
Evidence			Evidence
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:RelatesToWithQuotation		0..*	(Complex)	Related artifact with quoted portion URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/relates-to-with-quotation
extension:publicationStatus		0..1	CodeableConcept	Publication status URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/artifact-publication-status Binding: Cited Artifact Status Type (preferred)
Slices for variableDefinition		3..*	BackboneElement	Description, classification, and definition of a single variable Slice: Unordered, Open by value:variableRole
variableDefinition:population		1..*	BackboneElement	Description, classification, and definition of a single variable
variableRole		1..1	code	population | exposure | outcome | covariate Required Pattern: population
observed		0..1	Reference(StudyGroup | ExposureGroup | ComparatorGroup | MetaanalysisStudyGroup)	Definition of the actual variable related to the statistic(s)
intended		0..1	Reference(Group)	Definition of the intended variable related to the Evidence
variableDefinition:exposure		1..1	BackboneElement	Description, classification, and definition of a single variable
variableRole		1..1	code	population | exposure | outcome | covariate Required Pattern: exposure
comparatorCategory		1..1	string	The reference value used for comparison
observed		0..1	Reference(GroupAssignment)	Definition of the actual variable related to the statistic(s)
intended		0..1	Reference(VariableDefinition)	Definition of the intended variable related to the Evidence
variableDefinition:outcome	S	1..*	BackboneElement	Description, classification, and definition of a single variable
variableRole		1..1	code	population | exposure | outcome | covariate Required Pattern: outcome
comparatorCategory		0..0
observed		0..1	Reference(VariableDefinition)	Definition of the actual variable related to the statistic(s)
intended		0..1	Reference(EvidenceVariable)	Definition of the intended variable related to the Evidence
Documentation for this format

Snapshot View

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
Evidence	C	0..*	Evidence	Single evidence bit Constraints: cnl-0
id	Σ	0..1	id	Logical id of this artifact
meta	Σ	0..1	Meta	Metadata about the resource
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
language		0..1	code	Language of the resource content Binding: AllLanguages (required): IETF language tag for a human language Additional Bindings Purpose CommonLanguages Starter
text		0..1	Narrative	Text summary of the resource, for human interpretation This profile does not constrain the narrative in regard to content, language, or traceability to data elements
contained		0..*	Resource	Contained, inline Resources
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:RelatesToWithQuotation		0..*	(Complex)	Related artifact with quoted portion URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/relates-to-with-quotation
extension:publicationStatus		0..1	CodeableConcept	Publication status URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/artifact-publication-status Binding: Cited Artifact Status Type (preferred)
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored
url	ΣC	0..1	uri	Canonical identifier for this evidence, represented as a globally unique URI Constraints: cnl-1
identifier	Σ	0..*	Identifier	Additional identifier for the summary
version	Σ	0..1	string	Business version of this summary
versionAlgorithm[x]	Σ	0..1		How to compare versions Binding: VersionAlgorithm (extensible)
versionAlgorithmString			string
versionAlgorithmCoding			Coding
name	C	0..1	string	Name for this summary (machine friendly)
title	Σ	0..1	string	Name for this summary (human friendly)
citeAs		0..1	markdown	Display of how to cite this Evidence
status	?!Σ	1..1	code	draft | active | retired | unknown Binding: PublicationStatus (required): The lifecycle status of an artifact.
experimental		0..1	boolean	For testing only - never for real usage
date	Σ	0..1	dateTime	Date last changed
approvalDate		0..1	date	When the summary was approved by publisher
lastReviewDate		0..1	date	When the summary was last reviewed by the publisher
author	Σ	0..*	ContactDetail	Who authored the content
publisher	Σ	0..1	string	Name of the publisher/steward (organization or individual)
contact	Σ	0..*	ContactDetail	Contact details for the publisher
recorder		0..*	ContactDetail	Who entered the data for the evidence
editor		0..*	ContactDetail	Who edited the content
reviewer		0..*	ContactDetail	Who reviewed the content
endorser		0..*	ContactDetail	Who endorsed the content
useContext	Σ	0..*	UsageContext	The context that the content is intended to support
purpose		0..1	markdown	Why this Evidence is defined
copyright		0..1	markdown	Intellectual property ownership, may include restrictions on use
copyrightLabel		0..1	string	Copyright holder and year(s)
relatesTo		0..*	BackboneElement	Relationships to other Resources
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
type		1..1	code	documentation | justification | predecessor | successor | derived-from | depends-on | composed-of | part-of | amends | amended-with | appends | appended-with | cites | cited-by | comments-on | comment-in | contains | contained-in | corrects | correction-in | replaces | replaced-with | retracts | retracted-by | signs | similar-to | supports | supported-with | transforms | transformed-into | transformed-with | specification-of | created-with | cite-as | summarizes Binding: ArtifactRelationshipType (required): The type of relationship to the related artifact.
target[x]		1..1		The artifact that is related to this Evidence
targetUri			uri
targetAttachment			Attachment
targetCanonical			canonical(Resource)
targetReference			Reference(Resource)
targetMarkdown			markdown
description	Σ	0..1	markdown	Description of the particular summary
assertion		0..1	markdown	Declarative description of the Evidence
note		0..*	Annotation	Footnotes and/or explanatory notes
Slices for variableDefinition		3..*	BackboneElement	Description, classification, and definition of a single variable Slice: Unordered, Open by value:variableRole
variableDefinition:All Slices				Content/Rules for all slices
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	A text description or summary of the variable
note		0..*	Annotation	Footnotes and/or explanatory notes
variableRole	Σ	1..1	code	population | exposure | outcome | covariate Binding: EvidenceVariableRole (required): The role that the variable plays.
roleSubtype		0..1	CodeableConcept	Sub-classification of the role of the variable Binding: EvidenceVariableRoleSubtype (extensible): The sub-role that the variable plays.
comparatorCategory		0..1	string	The reference value used for comparison
observed	Σ	0..1	Reference(Group | EvidenceVariable)	Definition of the actual variable related to the statistic(s)
intended		0..1	Reference(Group | EvidenceVariable)	Definition of the intended variable related to the Evidence
directnessMatch		0..1	CodeableConcept	low | moderate | high | exact Binding: EvidenceDirectness (extensible): The quality of how direct the match is.
variableDefinition:population		1..*	BackboneElement	Description, classification, and definition of a single variable
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	A text description or summary of the variable
note		0..*	Annotation	Footnotes and/or explanatory notes
variableRole	Σ	1..1	code	population | exposure | outcome | covariate Binding: EvidenceVariableRole (required): The role that the variable plays. Required Pattern: population
roleSubtype		0..1	CodeableConcept	Sub-classification of the role of the variable Binding: EvidenceVariableRoleSubtype (extensible): The sub-role that the variable plays.
comparatorCategory		0..1	string	The reference value used for comparison
observed	Σ	0..1	Reference(StudyGroup | ExposureGroup | ComparatorGroup | MetaanalysisStudyGroup)	Definition of the actual variable related to the statistic(s)
intended		0..1	Reference(Group)	Definition of the intended variable related to the Evidence
directnessMatch		0..1	CodeableConcept	low | moderate | high | exact Binding: EvidenceDirectness (extensible): The quality of how direct the match is.
variableDefinition:exposure		1..1	BackboneElement	Description, classification, and definition of a single variable
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	A text description or summary of the variable
note		0..*	Annotation	Footnotes and/or explanatory notes
variableRole	Σ	1..1	code	population | exposure | outcome | covariate Binding: EvidenceVariableRole (required): The role that the variable plays. Required Pattern: exposure
roleSubtype		0..1	CodeableConcept	Sub-classification of the role of the variable Binding: EvidenceVariableRoleSubtype (extensible): The sub-role that the variable plays.
comparatorCategory		1..1	string	The reference value used for comparison
observed	Σ	0..1	Reference(GroupAssignment)	Definition of the actual variable related to the statistic(s)
intended		0..1	Reference(VariableDefinition)	Definition of the intended variable related to the Evidence
directnessMatch		0..1	CodeableConcept	low | moderate | high | exact Binding: EvidenceDirectness (extensible): The quality of how direct the match is.
variableDefinition:outcome	S	1..*	BackboneElement	Description, classification, and definition of a single variable
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	A text description or summary of the variable
note		0..*	Annotation	Footnotes and/or explanatory notes
variableRole	Σ	1..1	code	population | exposure | outcome | covariate Binding: EvidenceVariableRole (required): The role that the variable plays. Required Pattern: outcome
roleSubtype		0..1	CodeableConcept	Sub-classification of the role of the variable Binding: EvidenceVariableRoleSubtype (extensible): The sub-role that the variable plays.
observed	Σ	0..1	Reference(VariableDefinition)	Definition of the actual variable related to the statistic(s)
intended		0..1	Reference(EvidenceVariable)	Definition of the intended variable related to the Evidence
directnessMatch		0..1	CodeableConcept	low | moderate | high | exact Binding: EvidenceDirectness (extensible): The quality of how direct the match is.
synthesisType		0..*	CodeableConcept	The design of the synthesis (combination of studies) that produced this evidence Binding: StatisticSynthesisType (extensible): Types of combining results from a body of evidence (e.g. summary data meta-analysis).
studyDesign		0..*	CodeableConcept	The design of the study that produced this evidence Binding: StudyDesign (extensible): This is a set of terms for study design characteristics.
statistic		0..*	BackboneElement	Values and parameters for a single statistic
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	A natural language summary of the statistic
note		0..*	Annotation	Footnotes and/or explanatory notes
statisticType	Σ	0..1	CodeableConcept	Type of statistic, e.g., relative risk Binding: StatisticType (extensible)
category		0..1	CodeableConcept	Associated category for categorical variable
quantity	Σ	0..1	Quantity	Statistic value
numberOfEvents		0..1	unsignedInt	The number of events associated with the statistic
numberAffected		0..1	unsignedInt	The number of participants affected
sampleSize		0..1	BackboneElement	Count of participants in the study sample
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	Textual description of sample size for statistic
note		0..*	Annotation	Footnote or explanatory note about the sample size
numberOfStudies		0..1	unsignedInt	Number of contributing studies
numberOfParticipants		0..1	unsignedInt	Total number of participants
knownDataCount		0..1	unsignedInt	Number of participants with known results for measured variables
attributeEstimate		0..*	BackboneElement	An attribute of the Statistic
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	Textual description of the attribute estimate
note		0..*	Annotation	Footnote or explanatory note about the estimate
type		0..1	CodeableConcept	The type of attribute estimate, e.g., confidence interval or p value Binding: AttributeEstimateType (extensible)
quantity		0..1	Quantity	The singular quantity of the attribute estimate, for attribute estimates represented as single values, which may include a unit of measure
level		0..1	decimal	Level of confidence interval, e.g., 0.95 for 95% confidence interval
range		0..1	Range	Lower and upper bound values of the attribute estimate
attributeEstimate		0..*	See attributeEstimate (Evidence)	A nested attribute estimate; which is the attribute estimate of an attribute estimate
modelCharacteristic		0..*	BackboneElement	An aspect of the statistical model
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
code		1..1	CodeableConcept	Model specification Binding: StatisticModelCode (extensible)
value[x]		0..1		The specific value (when paired with code)
valueQuantity			Quantity(SimpleQuantity)
valueRange			Range
valueCodeableConcept			CodeableConcept
intended		0..1	boolean	The plan for analysis
applied		0..1	boolean	This model characteristic is part of the analysis that was applied, whether or not the analysis followed the plan
variable		0..*	BackboneElement	A variable adjusted for in the adjusted analysis
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
variableDefinition		1..1	Reference(Group | EvidenceVariable)	Description and definition of the variable
handling		0..1	code	boolean | continuous | dichotomous | ordinal | polychotomous | extension Binding: EvidenceVariableHandling (required)
valueCategory		0..*	CodeableConcept	Qualitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable
valueQuantity		0..*	Quantity	Quantitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable
valueRange		0..*	Range	Range of quantitative labels used for grouping values of a dichotomous, ordinal, or polychotomous variable
attribute		0..*	See attributeEstimate (Evidence)	An attribute of the model characteristic
certainty		0..*	BackboneElement	Certainty or quality of the evidence
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	Textual description of certainty
note		0..*	Annotation	Footnotes and/or explanatory notes
type		0..1	CodeableConcept	Aspect of certainty being rated Binding: EvidenceCertaintyType (extensible): The aspect of quality, confidence, or certainty.
rating		0..1	CodeableConcept	Assessment or judgement of the aspect Binding: EvidenceCertaintyRating (extensible): The assessment of quality, confidence, or certainty.
rater		0..*	string	Individual or group who did the rating
subcomponent		0..*	See certainty (Evidence)	A domain or subdomain of certainty
Documentation for this format

Terminology Bindings

Path	Conformance	ValueSet / Code	URI
Evidence.language	required	AllLanguages http://hl7.org/fhir/ValueSet/all-languages|6.0.0-ballot3 From the FHIR Standard
Evidence.versionAlgorithm[x]	extensible	VersionAlgorithm http://hl7.org/fhir/ValueSet/version-algorithm From the FHIR Standard
Evidence.status	required	PublicationStatus http://hl7.org/fhir/ValueSet/publication-status|6.0.0-ballot3 From the FHIR Standard
Evidence.relatesTo.type	required	ArtifactRelationshipType http://hl7.org/fhir/ValueSet/artifact-relationship-type|6.0.0-ballot3 From the FHIR Standard
Evidence.variableDefinition.variableRole	required	EvidenceVariableRole http://hl7.org/fhir/ValueSet/variable-role|6.0.0-ballot3 From the FHIR Standard
Evidence.variableDefinition.roleSubtype	extensible	EvidenceVariableRoleSubtype http://hl7.org/fhir/ValueSet/variable-role-subtype From the FHIR Standard
Evidence.variableDefinition.directnessMatch	extensible	EvidenceDirectness http://terminology.hl7.org/ValueSet/directness
Evidence.variableDefinition:population.variableRole	required	Pattern Value: population http://hl7.org/fhir/ValueSet/variable-role|6.0.0-ballot3 From the FHIR Standard
Evidence.variableDefinition:population.roleSubtype	extensible	EvidenceVariableRoleSubtype http://hl7.org/fhir/ValueSet/variable-role-subtype From the FHIR Standard
Evidence.variableDefinition:population.directnessMatch	extensible	EvidenceDirectness http://terminology.hl7.org/ValueSet/directness
Evidence.variableDefinition:exposure.variableRole	required	Pattern Value: exposure http://hl7.org/fhir/ValueSet/variable-role|6.0.0-ballot3 From the FHIR Standard
Evidence.variableDefinition:exposure.roleSubtype	extensible	EvidenceVariableRoleSubtype http://hl7.org/fhir/ValueSet/variable-role-subtype From the FHIR Standard
Evidence.variableDefinition:exposure.directnessMatch	extensible	EvidenceDirectness http://terminology.hl7.org/ValueSet/directness
Evidence.variableDefinition:outcome.variableRole	required	Pattern Value: outcome http://hl7.org/fhir/ValueSet/variable-role|6.0.0-ballot3 From the FHIR Standard
Evidence.variableDefinition:outcome.roleSubtype	extensible	EvidenceVariableRoleSubtype http://hl7.org/fhir/ValueSet/variable-role-subtype From the FHIR Standard
Evidence.variableDefinition:outcome.directnessMatch	extensible	EvidenceDirectness http://terminology.hl7.org/ValueSet/directness
Evidence.synthesisType	extensible	StatisticSynthesisType http://terminology.hl7.org/ValueSet/synthesis-type
Evidence.studyDesign	extensible	StudyDesign http://hl7.org/fhir/ValueSet/study-design From the FHIR Standard
Evidence.statistic.statisticType	extensible	StatisticType http://hl7.org/fhir/ValueSet/statistic-type From the FHIR Standard
Evidence.statistic.attributeEstimate.type	extensible	AttributeEstimateType http://hl7.org/fhir/ValueSet/attribute-estimate-type From the FHIR Standard
Evidence.statistic.modelCharacteristic.code	extensible	StatisticModelCode http://hl7.org/fhir/ValueSet/statistic-model-code From the FHIR Standard
Evidence.statistic.modelCharacteristic.variable.handling	required	EvidenceVariableHandling http://hl7.org/fhir/ValueSet/variable-handling|6.0.0-ballot3 From the FHIR Standard
Evidence.certainty.type	extensible	EvidenceCertaintyType http://hl7.org/fhir/ValueSet/certainty-type From the FHIR Standard
Evidence.certainty.rating	extensible	EvidenceCertaintyRating http://hl7.org/fhir/ValueSet/certainty-rating From the FHIR Standard

Constraints

Id	Grade	Path(s)	Details	Requirements
cnl-0	warning	Evidence	Name should be usable as an identifier for the module by machine processing applications such as code generation : name.exists() implies name.matches('^[A-Z]([A-Za-z0-9_]){1,254}$')
cnl-1	warning	Evidence.url	URL should not contain | or # - these characters make processing canonical references problematic : exists() implies matches('^[^|# ]+$')
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children : hasValue() or (children().count() > id.count())
ext-1	error	**ALL** extensions	Must have either extensions or value[x], not both : extension.exists() != value.exists()

This structure is derived from Evidence

Summary

Mandatory: 4 elements
Must-Support: 1 element
Prohibited: 1 element

Structures

This structure refers to these other structures:

• StudyGroup (http://hl7.org/fhir/uv/ebm/StructureDefinition/study-group)
• ExposureGroup (http://hl7.org/fhir/uv/ebm/StructureDefinition/exposure-group)
• ComparatorGroup (http://hl7.org/fhir/uv/ebm/StructureDefinition/comparator-group)
• MetaanalysisStudyGroup (http://hl7.org/fhir/uv/ebm/StructureDefinition/metaanalysis-study-group)
• GroupAssignment (http://hl7.org/fhir/uv/ebm/StructureDefinition/group-assignment)
• VariableDefinition (http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition)

Extensions

This structure refers to these extensions:

• http://hl7.org/fhir/uv/ebm/StructureDefinition/relates-to-with-quotation
• http://hl7.org/fhir/uv/ebm/StructureDefinition/artifact-publication-status

Slices

This structure defines the following Slices:

• The element 1 is sliced based on the value of Evidence.variableDefinition

Maturity: 1

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