Evidence Based Medicine on FHIR Implementation Guide
2.0.0-ballot - ballot
Evidence Based Medicine on FHIR Implementation Guide
2.0.0-ballot - ballot
Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 2.0.0-ballot built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions
| Active as of 2022-09-19 |
Generated Narrative: Evidence 104098
version: 14; Last updated: 2023-12-06 17:20:30+0000
Profiles: ComparativeEvidence, SingleStudyEvidence
identifier: FEvIR Object Identifier/104098, Uniform Resource Identifier (URI)/urn:oid:2.16.840.1.113883.4.642.40.44.22.11
version: 2.0.0-ballot
name: ComparativeEvidence_Bypass_surgery_effects_on_Myocardial_infarction_or_stroke_in_Swedish_Obese_Subjects_SOS_study
title: ComparativeEvidence: Bypass surgery effects on Myocardial infarction or stroke in Swedish Obese Subjects (SOS) study
status: Active
date: 2022-09-19 21:15:57+0000
publisher: HL7 International / Clinical Decision Support
contact: HL7 International / Clinical Decision Support: http://www.hl7.org/Special/committees/dss
author: Brian S. Alper:
copyright:
https://creativecommons.org/licenses/by-nc-sa/4.0/
relatedArtifact
type: Derived From
Documents
Url https://jamanetwork.com/journals/jama/fullarticle/1103994
relatedArtifact
type: Cite As
citation:
ComparativeEvidence: Bypass surgery effects on Myocardial infarction or stroke in Swedish Obese Subjects (SOS) study [Evidence]. Contributors: Brian S. Alper [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 104098. Revised 2022-09-19. Available at: https://fevir.net/resources/Evidence/104098. Computable resource at: https://fevir.net/resources/Evidence/104098.
description:
Bariatric surgery was associated with a reduced number of cardiovascular deaths (28 events among 2010 patients in the surgery group vs 49 events among 2037 patients in the control group; adjusted hazard ratio [HR], 0.47; 95% CI, 0.29-0.76; P = .002). The number of total first time (fatal or nonfatal) cardiovascular events (myocardial infarction or stroke, whichever came first) was lower in the surgery group (199 events among 2010 patients) than in the control group (234 events among 2037 patients; adjusted HR, 0.67; 95% CI, 0.54-0.83; P < .001). -- Extrapolated from this data the outcome of Nonfatal myocardial infarction or stroke occurred in 188 out of 2037 patients in the control group and 171 out of 2010 patients in the surgery group, and the adjusted HR for total events is assumed to apply (adjusted HR 0.67, 95% CI 0.54 to 0.83)
assertion:
Compared with usual care, bariatric surgery was associated with reduced number of cardiovascular deaths and lower incidence of cardiovascular events in obese adults.
variableDefinition
org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code: population
description:
Inclusion criteria were age 37 to 60 years and a body mass index of at least 34 in men and at least 38 in women. All in Sweden.
note: population
variableDefinition
org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code: exposure
org/fhir/uv/ebm/StructureDefinition/variable-definition-comparator-category: no bariatric surgery
description:
bariatric surgery vs. usual care without bariatric surgery
note: exposure
intended: GroupAssignment: Bariatric Surgery vs. no bariatric surgery
variableDefinition
org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code: outcome
description:
nonfatal myocardial infarction or stroke
note: outcome
observed: OutcomeVariable: Nonfatal myocardial infarction or stroke
synthesisType: not applicable
studyDesign: Observational research, Parallel cohort design, Matching for comparison, Longitudinal data collection
statistic
description:
Hazard ratio, adjusted 0.67; 95% CI 0.54 to 0.83
note: The event rates are calculated from the reported total (fatal and nonfatal events) minus the fatal events. Nonfatal myocardial infarction or stroke occurred in 188 out of 2037 patients in the control group and 171 out of 2010 patients in the surgery group, and the adjusted HR for total events is assumed to apply (adjusted HR 0.67, 95% CI 0.54 to 0.83)
statisticType: Hazard Ratio
quantity: 0.67
numberAffected: 359
SampleSizes
NumberOfParticipants KnownDataCount 4047 4047 AttributeEstimates
Description Type Level Range 95% CI 0.54 to 0.83
Confidence interval 0.95 0.54-0.83 ModelCharacteristics
Code Adjusted analysis
| Type | Rating |
| Overall certainty | Low quality |
IG © 2024+ HL7 International / Clinical Decision Support. Package hl7.fhir.uv.ebm#2.0.0-ballot based on FHIR 6.0.0-ballot2. Generated 2024-11-01
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