Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions

• Content
• Detailed Descriptions
• Mappings
• Examples
• XML
• JSON
• TTL

Resource Profile: NetEffectContribution

Profile of Evidence for Evidence Based Medicine IG. The NetEffectContribution Profile is used for evidence in which the effect estimates, expressed as risk differences, is multiplied by a relative importance rating of the outcomes.

Usage:

• Refer to this Resource Profile: NetEffectContributionList and SummaryOfNetEffect
• Examples for this Resource Profile: NetEffectContribution_All_cause_mortality_for_Example_for_GIN_2022, NetEffectContribution_Nonfatal_myocardial_infarction_or_stroke_for_Example_for_GIN_2022, NetEffectContribution_Remission_of_diabetes_for_Example_for_GIN_2022, NetEffectContribution_New_onset_depression_for_Example_for_GIN_2022... Show 2 more, NetEffectContribution_Treatment_with_opioids_for_Example_for_GIN_2022 and NetEffectContribution_Additional_GI_surgical_procedure_for_Example_for_GIN_2022

Formal Views of Profile Content

Description of Profiles, Differentials, Snapshots and how the different presentations work.

• Differential Table
• Key Elements Table
• Snapshot Table
• Statistics/References
• All

This structure is derived from ComparativeEvidence

Name	Flags	Card.	Type	Description & Constraints
Evidence			ComparativeEvidence
Slices for relatedArtifact		1..*	RelatedArtifact	Link or citation to artifact associated with the summary Slice: Unordered, Open by value:type
relatedArtifact:amendedWith	S	1..*	RelatedArtifact	Link or citation to artifact associated with the summary
type		1..1	code	documentation | justification | citation | predecessor | successor | derived-from | depends-on | composed-of | part-of | amends | amended-with | appends | appended-with | cites | cited-by | comments-on | comment-in | contains | contained-in | corrects | correction-in | replaces | replaced-with | retracts | retracted-by | signs | similar-to | supports | supported-with | transforms | transformed-into | transformed-with | documents | specification-of | created-with | cite-as Required Pattern: amended-with
resourceReference		0..1	Reference(OutcomeImportance)	What artifact, if not a conformance resource
relatedArtifact:citeAs		0..1	RelatedArtifact	Link or citation to artifact associated with the summary
type		1..1	code	documentation | justification | citation | predecessor | successor | derived-from | depends-on | composed-of | part-of | amends | amended-with | appends | appended-with | cites | cited-by | comments-on | comment-in | contains | contained-in | corrects | correction-in | replaces | replaced-with | retracts | retracted-by | signs | similar-to | supports | supported-with | transforms | transformed-into | transformed-with | documents | specification-of | created-with | cite-as Required Pattern: cite-as
variableDefinition		4..*	BackboneElement	Evidence variable such as population, exposure, or outcome
variableDefinition:covariate		1..*	BackboneElement	Evidence variable such as population, exposure, or outcome
extension:variableRoleCode		1..1	VariableDefinitionVariableRoleCode	population | exposure | outcome | covariate
value[x]		0..1	code	Value of extension Required Pattern: covariate
extension:roleSubtype		0..1	VariableDefinitionRoleSubtype	subgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier
value[x]
text		0..1	string	Plain text representation of the concept Required Pattern: Relative Value Multiplier
extension:comparatorCategory		0..1	VariableDefinitionComparatorCategory	The reference value used for comparison
note
text		1..1	markdown	The annotation - text content (as markdown) Required Pattern: covariate
observed
display		0..1	string	Text alternative for the resource Required Pattern: Relative Importance Multiplier
intended		0..0
Slices for statistic		1..*	BackboneElement	Values and parameters for a single statistic Slice: Unordered, Open by value:statisticType.coding
statistic:netEffect	S	1..1	BackboneElement	Values and parameters for a single statistic
extension:modelExpression		0..1	StatisticModelExpression	The formula for analysis
statisticType
coding		1..1	Coding	Code defined by a terminology system Required Pattern: At least the following
system		1..1	uri	Identity of the terminology system Fixed Value: https://fevir.net/resources/CodeSystem/181513
code		1..1	code	Symbol in syntax defined by the system Fixed Value: STATO:0000424
display		1..1	string	Representation defined by the system Fixed Value: Risk Difference
Slices for attributeEstimate		1..*	BackboneElement	An attribute of the Statistic Slice: Unordered, Open by value:type.coding
attributeEstimate:confidenceInterval	S	1..1	BackboneElement	An attribute of the Statistic
type
coding		1..1	Coding	Code defined by a terminology system Required Pattern: At least the following
system		1..1	uri	Identity of the terminology system Fixed Value: https://fevir.net/resources/CodeSystem/181513
code		1..1	code	Symbol in syntax defined by the system Fixed Value: STATO:0000196
display		1..1	string	Representation defined by the system Fixed Value: confidence interval
Slices for modelCharacteristic		1..*	BackboneElement	An aspect of the statistical model Slice: Unordered, Open by value:code.coding
modelCharacteristic:All Slices				Content/Rules for all slices
extension:valueQuantity		0..1	StatisticModelValueQuantity	Value as Quantity
extension:valueRange		0..1	StatisticModelValueRange	Value as Range
extension:valueCodeableConcept		0..1	StatisticModelValueCodeableConcept	Value as CodeableConcept
extension:intended		0..1	StatisticModelIntended	The plan for analysis
extension:applied		0..1	StatisticModelApplied	The analysis that was applied
extension:includeIf		0..1	StatisticModelIncludeIf	Condition upon which to include the variable or model characteristic in the analysis
variable
extension:includeIf		0..1	StatisticModelIncludeIf	Condition upon which to include the variable or model characteristic in the analysis
modelCharacteristic:netEffectContributionAnalysis	S	1..1	BackboneElement	An aspect of the statistical model
extension:valueQuantity		0..1	StatisticModelValueQuantity	Value as Quantity
extension:valueRange		0..1	StatisticModelValueRange	Value as Range
extension:valueCodeableConcept		0..1	StatisticModelValueCodeableConcept	Value as CodeableConcept
extension:intended		0..1	StatisticModelIntended	The plan for analysis
extension:applied		0..1	StatisticModelApplied	The analysis that was applied
extension:includeIf		0..1	StatisticModelIncludeIf	Condition upon which to include the variable or model characteristic in the analysis
code
coding		1..1	Coding	Code defined by a terminology system Required Pattern: At least the following
system		1..1	uri	Identity of the terminology system Fixed Value: https://fevir.net/resources/CodeSystem/181513
code		1..1	code	Symbol in syntax defined by the system Fixed Value: TBD:net-effect-contribution-analysis
display		1..1	string	Representation defined by the system Fixed Value: Net effect contribution analysis
variable
extension:includeIf		0..1	StatisticModelIncludeIf	Condition upon which to include the variable or model characteristic in the analysis
Documentation for this format

Name	Flags	Card.	Type	Description & Constraints
Evidence	C	0..*	ComparativeEvidence	Single evidence bit cnl-0: Name should be usable as an identifier for the module by machine processing applications such as code generation
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
contained		0..*	Resource	Contained, inline Resources
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored
status	?!Σ	1..1	code	draft | active | retired | unknown Binding: PublicationStatus (required): The lifecycle status of an artifact.
Slices for relatedArtifact		1..*	RelatedArtifact	Link or citation to artifact associated with the summary Slice: Unordered, Open by value:type
relatedArtifact:amendedWith	S	1..*	RelatedArtifact	Link or citation to artifact associated with the summary
type	Σ	1..1	code	documentation | justification | citation | predecessor | successor | derived-from | depends-on | composed-of | part-of | amends | amended-with | appends | appended-with | cites | cited-by | comments-on | comment-in | contains | contained-in | corrects | correction-in | replaces | replaced-with | retracts | retracted-by | signs | similar-to | supports | supported-with | transforms | transformed-into | transformed-with | documents | specification-of | created-with | cite-as Binding: RelatedArtifactType (required): The type of relationship to the related artifact. Required Pattern: amended-with
resourceReference	Σ	0..1	Reference(OutcomeImportance)	What artifact, if not a conformance resource
relatedArtifact:citeAs		0..1	RelatedArtifact	Link or citation to artifact associated with the summary
type	Σ	1..1	code	documentation | justification | citation | predecessor | successor | derived-from | depends-on | composed-of | part-of | amends | amended-with | appends | appended-with | cites | cited-by | comments-on | comment-in | contains | contained-in | corrects | correction-in | replaces | replaced-with | retracts | retracted-by | signs | similar-to | supports | supported-with | transforms | transformed-into | transformed-with | documents | specification-of | created-with | cite-as Binding: RelatedArtifactType (required): The type of relationship to the related artifact. Required Pattern: cite-as
Slices for variableDefinition		4..*	BackboneElement	Evidence variable such as population, exposure, or outcome Slice: Unordered, Open by value:note.text
variableDefinition:All Slices				Content/Rules for all slices
Slices for extension		1..*	Extension	Extension Slice: Unordered, Open by value:url
variableRoleCode		1..1	code	population | exposure | outcome | covariate URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code
roleSubtype		0..1	CodeableConcept	subgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-role-subtype Binding: EvidenceVariableRoleSubtype Value Set (extensible)
comparatorCategory		0..1	string	The reference value used for comparison URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-comparator-category
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
variableRole	Σ	1..1	CodeableConcept	population | subpopulation | exposure | referenceExposure | measuredVariable | confounder Binding: EvidenceVariableRole (extensible): The role that the assertion variable plays.
variableDefinition:population		1..*	BackboneElement	Evidence variable such as population, exposure, or outcome
Slices for extension		1..*	Extension	Extension Slice: Unordered, Open by value:url
variableRoleCode		1..1	(Complex)	population | exposure | outcome | covariate URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code
extension		0..0
url		1..1	uri	"http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code"
roleSubtype		0..1	CodeableConcept	subgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-role-subtype Binding: EvidenceVariableRoleSubtype Value Set (extensible)
comparatorCategory		0..1	string	The reference value used for comparison URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-comparator-category
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
variableRole	Σ	1..1	CodeableConcept	population | subpopulation | exposure | referenceExposure | measuredVariable | confounder Binding: EvidenceVariableRole (extensible): The role that the assertion variable plays.
variableDefinition:exposure		1..1	BackboneElement	Evidence variable such as population, exposure, or outcome
Slices for extension		2..*	Extension	Extension Slice: Unordered, Open by value:url
variableRoleCode		1..1	(Complex)	population | exposure | outcome | covariate URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code
extension		0..0
url		1..1	uri	"http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code"
roleSubtype		0..1	CodeableConcept	subgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-role-subtype Binding: EvidenceVariableRoleSubtype Value Set (extensible)
comparatorCategory		1..1	string	The reference value used for comparison URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-comparator-category
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
variableRole	Σ	1..1	CodeableConcept	population | subpopulation | exposure | referenceExposure | measuredVariable | confounder Binding: EvidenceVariableRole (extensible): The role that the assertion variable plays.
variableDefinition:outcome	S	1..*	BackboneElement	Evidence variable such as population, exposure, or outcome
Slices for extension		1..*	Extension	Extension Slice: Unordered, Open by value:url
variableRoleCode		1..1	(Complex)	population | exposure | outcome | covariate URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code
extension		0..0
url		1..1	uri	"http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code"
roleSubtype		0..1	CodeableConcept	subgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-role-subtype Binding: EvidenceVariableRoleSubtype Value Set (extensible)
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
variableRole	Σ	1..1	CodeableConcept	population | subpopulation | exposure | referenceExposure | measuredVariable | confounder Binding: EvidenceVariableRole (extensible): The role that the assertion variable plays.
variableDefinition:covariate		1..*	BackboneElement	Evidence variable such as population, exposure, or outcome
Slices for extension		1..*	Extension	Extension Slice: Unordered, Open by value:url
variableRoleCode		1..1	(Complex)	population | exposure | outcome | covariate URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code
extension		0..0
url		1..1	uri	"http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code"
value[x]		0..1	code	Value of extension Required Pattern: covariate
roleSubtype		0..1	(Complex)	subgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-role-subtype
extension		0..0
url		1..1	uri	"http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-role-subtype"
comparatorCategory		0..1	string	The reference value used for comparison URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-comparator-category
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
variableRole	Σ	1..1	CodeableConcept	population | subpopulation | exposure | referenceExposure | measuredVariable | confounder Binding: EvidenceVariableRole (extensible): The role that the assertion variable plays.
Slices for statistic		1..*	BackboneElement	Values and parameters for a single statistic Slice: Unordered, Open by value:statisticType.coding
statistic:All Slices				Content/Rules for all slices
modelExpression		0..1	Expression	The formula for analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-expression
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
statistic:netEffect	S	1..1	BackboneElement	Values and parameters for a single statistic
modelExpression		0..1	Expression	The formula for analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-expression
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
Slices for attributeEstimate		1..*	BackboneElement	An attribute of the Statistic Slice: Unordered, Open by value:type.coding
attributeEstimate:All Slices				Content/Rules for all slices
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
attributeEstimate:confidenceInterval	S	1..1	BackboneElement	An attribute of the Statistic
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
Slices for modelCharacteristic		1..*	BackboneElement	An aspect of the statistical model Slice: Unordered, Open by value:code.coding
modelCharacteristic:All Slices				Content/Rules for all slices
valueQuantity		0..1	SimpleQuantity	Value as Quantity URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-quantity
valueRange		0..1	Range	Value as Range URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-range
valueCodeableConcept		0..1	CodeableConcept	Value as CodeableConcept URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-codeableconcept
intended		0..1	boolean	The plan for analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-intended
applied		0..1	boolean	The analysis that was applied URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-applied
includeIf		0..1	(Complex)	Condition upon which to include the variable or model characteristic in the analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-include-if
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
code		1..1	CodeableConcept	Model specification Binding: StatisticModelCode (extensible)
modelCharacteristic:netEffectContributionAnalysis	S	1..1	BackboneElement	An aspect of the statistical model
valueQuantity		0..1	SimpleQuantity	Value as Quantity URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-quantity
valueRange		0..1	Range	Value as Range URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-range
valueCodeableConcept		0..1	CodeableConcept	Value as CodeableConcept URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-codeableconcept
intended		0..1	boolean	The plan for analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-intended
applied		0..1	boolean	The analysis that was applied URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-applied
includeIf		0..1	(Complex)	Condition upon which to include the variable or model characteristic in the analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-include-if
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
code		1..1	CodeableConcept	Model specification Binding: StatisticModelCode (extensible)
coding	Σ	1..1	Coding	Code defined by a terminology system Required Pattern: At least the following
system		1..1	uri	Identity of the terminology system Fixed Value: https://fevir.net/resources/CodeSystem/181513
code		1..1	code	Symbol in syntax defined by the system Fixed Value: TBD:net-effect-contribution-analysis
display		1..1	string	Representation defined by the system Fixed Value: Net effect contribution analysis
Documentation for this format

Terminology Bindings

Path	Conformance	ValueSet / Code	URI
Evidence.status	required	PublicationStatus http://hl7.org/fhir/ValueSet/publication-status|5.0.0 from the FHIR Standard
Evidence.relatedArtifact:amendedWith.type	required	Pattern: amended-with http://hl7.org/fhir/ValueSet/related-artifact-type|5.0.0 from the FHIR Standard
Evidence.relatedArtifact:citeAs.type	required	Pattern: cite-as http://hl7.org/fhir/ValueSet/related-artifact-type|5.0.0 from the FHIR Standard
Evidence.variableDefinition.variableRole	extensible	EvidenceVariableRole http://hl7.org/fhir/ValueSet/variable-role from the FHIR Standard
Evidence.variableDefinition:population.variableRole	extensible	EvidenceVariableRole http://hl7.org/fhir/ValueSet/variable-role from the FHIR Standard
Evidence.variableDefinition:exposure.variableRole	extensible	EvidenceVariableRole http://hl7.org/fhir/ValueSet/variable-role from the FHIR Standard
Evidence.variableDefinition:outcome.variableRole	extensible	EvidenceVariableRole http://hl7.org/fhir/ValueSet/variable-role from the FHIR Standard
Evidence.variableDefinition:covariate.variableRole	extensible	EvidenceVariableRole http://hl7.org/fhir/ValueSet/variable-role from the FHIR Standard
Evidence.statistic:netEffect.modelCharacteristic.code	extensible	StatisticModelCode http://hl7.org/fhir/ValueSet/statistic-model-code from the FHIR Standard
Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.code	extensible	StatisticModelCode http://hl7.org/fhir/ValueSet/statistic-model-code from the FHIR Standard

Constraints

Id	Grade	Path(s)	Details	Requirements
cnl-0	warning	Evidence	Name should be usable as an identifier for the module by machine processing applications such as code generation : name.exists() implies name.matches('^[A-Z]([A-Za-z0-9_]){1,254}$')
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children : hasValue() or (children().count() > id.count())
ext-1	error	**ALL** extensions	Must have either extensions or value[x], not both : extension.exists() != value.exists()

Name	Flags	Card.	Type	Description & Constraints
Evidence	C	0..*	ComparativeEvidence	Single evidence bit cnl-0: Name should be usable as an identifier for the module by machine processing applications such as code generation
id	Σ	0..1	id	Logical id of this artifact
meta	Σ	0..1	Meta	Metadata about the resource
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
language		0..1	code	Language of the resource content Binding: AllLanguages (required): IETF language tag for a human language Additional Bindings Purpose CommonLanguages Starter Set
text		0..1	Narrative	Text summary of the resource, for human interpretation
contained		0..*	Resource	Contained, inline Resources
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored
url	ΣC	0..1	uri	Canonical identifier for this evidence, represented as a globally unique URI cnl-1: URL should not contain | or # - these characters make processing canonical references problematic
identifier	Σ	0..*	Identifier	Additional identifier for the summary
version	Σ	0..1	string	Business version of this summary
versionAlgorithm[x]	Σ	0..1		How to compare versions Binding: VersionAlgorithm (extensible)
versionAlgorithmString			string
versionAlgorithmCoding			Coding
name	C	0..1	string	Name for this summary (machine friendly)
title	Σ	0..1	string	Name for this summary (human friendly)
citeAs[x]		0..1		Citation for this evidence
citeAsReference			Reference(Citation)
citeAsMarkdown			markdown
status	?!Σ	1..1	code	draft | active | retired | unknown Binding: PublicationStatus (required): The lifecycle status of an artifact.
experimental		0..1	boolean	For testing purposes, not real usage
date	Σ	0..1	dateTime	Date last changed
approvalDate		0..1	date	When the summary was approved by publisher
lastReviewDate		0..1	date	When the summary was last reviewed by the publisher
publisher	Σ	0..1	string	Name of the publisher/steward (organization or individual)
contact	Σ	0..*	ContactDetail	Contact details for the publisher
author	Σ	0..*	ContactDetail	Who authored the content
editor		0..*	ContactDetail	Who edited the content
reviewer		0..*	ContactDetail	Who reviewed the content
endorser	Σ	0..*	ContactDetail	Who endorsed the content
useContext	Σ	0..*	UsageContext	The context that the content is intended to support
purpose		0..1	markdown	Why this Evidence is defined
copyright		0..1	markdown	Use and/or publishing restrictions
copyrightLabel		0..1	string	Copyright holder and year(s)
Slices for relatedArtifact		1..*	RelatedArtifact	Link or citation to artifact associated with the summary Slice: Unordered, Open by value:type
relatedArtifact:amendedWith	S	1..*	RelatedArtifact	Link or citation to artifact associated with the summary
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
type	Σ	1..1	code	documentation | justification | citation | predecessor | successor | derived-from | depends-on | composed-of | part-of | amends | amended-with | appends | appended-with | cites | cited-by | comments-on | comment-in | contains | contained-in | corrects | correction-in | replaces | replaced-with | retracts | retracted-by | signs | similar-to | supports | supported-with | transforms | transformed-into | transformed-with | documents | specification-of | created-with | cite-as Binding: RelatedArtifactType (required): The type of relationship to the related artifact. Required Pattern: amended-with
classifier	Σ	0..*	CodeableConcept	Additional classifiers Binding: CitationArtifactClassifier (example): Additional classifiers for the related artifact.
label	Σ	0..1	string	Short label
display	Σ	0..1	string	Brief description of the related artifact
citation	Σ	0..1	markdown	Bibliographic citation for the artifact
document	Σ	0..1	Attachment	What document is being referenced
resource	Σ	0..1	canonical(Resource)	What artifact is being referenced
resourceReference	Σ	0..1	Reference(OutcomeImportance)	What artifact, if not a conformance resource
publicationStatus	Σ	0..1	code	draft | active | retired | unknown Binding: PublicationStatus (required): Publication status of an artifact being referred to.
publicationDate	Σ	0..1	date	Date of publication of the artifact being referred to
relatedArtifact:citeAs		0..1	RelatedArtifact	Link or citation to artifact associated with the summary
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
type	Σ	1..1	code	documentation | justification | citation | predecessor | successor | derived-from | depends-on | composed-of | part-of | amends | amended-with | appends | appended-with | cites | cited-by | comments-on | comment-in | contains | contained-in | corrects | correction-in | replaces | replaced-with | retracts | retracted-by | signs | similar-to | supports | supported-with | transforms | transformed-into | transformed-with | documents | specification-of | created-with | cite-as Binding: RelatedArtifactType (required): The type of relationship to the related artifact. Required Pattern: cite-as
classifier	Σ	0..*	CodeableConcept	Additional classifiers Binding: CitationArtifactClassifier (example): Additional classifiers for the related artifact.
label	Σ	0..1	string	Short label
display	Σ	0..1	string	Brief description of the related artifact
citation	Σ	0..1	markdown	Bibliographic citation for the artifact
document	Σ	0..1	Attachment	What document is being referenced
resource	Σ	0..1	canonical(Resource)	What artifact is being referenced
resourceReference	Σ	0..1	Reference(Resource)	What artifact, if not a conformance resource
publicationStatus	Σ	0..1	code	draft | active | retired | unknown Binding: PublicationStatus (required): Publication status of an artifact being referred to.
publicationDate	Σ	0..1	date	Date of publication of the artifact being referred to
description		0..1	markdown	Description of the particular summary
assertion		0..1	markdown	Declarative description of the Evidence
note		0..*	Annotation	Footnotes and/or explanatory notes
Slices for variableDefinition		4..*	BackboneElement	Evidence variable such as population, exposure, or outcome Slice: Unordered, Open by value:note.text
variableDefinition:All Slices				Content/Rules for all slices
id		0..1	string	Unique id for inter-element referencing
Slices for extension		1..*	Extension	Extension Slice: Unordered, Open by value:url
variableRoleCode		1..1	code	population | exposure | outcome | covariate URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code
roleSubtype		0..1	CodeableConcept	subgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-role-subtype Binding: EvidenceVariableRoleSubtype Value Set (extensible)
comparatorCategory		0..1	string	The reference value used for comparison URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-comparator-category
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	A text description or summary of the variable
note		0..*	Annotation	Footnotes and/or explanatory notes
variableRole	Σ	1..1	CodeableConcept	population | subpopulation | exposure | referenceExposure | measuredVariable | confounder Binding: EvidenceVariableRole (extensible): The role that the assertion variable plays.
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	Σ	0..*	Coding	Code defined by a terminology system
text	Σ	0..1	string	Plain text representation of the concept Required Pattern: Use extension:variableRoleCode instead.
observed	Σ	0..1	Reference(Group | EvidenceVariable)	Definition of the actual variable related to the statistic(s)
intended		0..1	Reference(Group | EvidenceVariable)	Definition of the intended variable related to the Evidence
directnessMatch		0..1	CodeableConcept	low | moderate | high | exact Binding: EvidenceDirectness (extensible): The quality of how direct the match is.
variableDefinition:population		1..*	BackboneElement	Evidence variable such as population, exposure, or outcome
id		0..1	string	Unique id for inter-element referencing
Slices for extension		1..*	Extension	Extension Slice: Unordered, Open by value:url
variableRoleCode		1..1	(Complex)	population | exposure | outcome | covariate URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code
id		0..1	id	Unique id for inter-element referencing
extension		0..0
url		1..1	uri	"http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code"
value[x]		0..1	code	Value of extension Required Pattern: population
roleSubtype		0..1	CodeableConcept	subgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-role-subtype Binding: EvidenceVariableRoleSubtype Value Set (extensible)
comparatorCategory		0..1	string	The reference value used for comparison URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-comparator-category
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	A text description or summary of the variable
note		0..*	Annotation	Footnotes and/or explanatory notes
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
author[x]	Σ	0..1		Individual responsible for the annotation
authorReference			Reference(Practitioner | PractitionerRole | Patient | RelatedPerson | Organization)
authorString			string
time	Σ	0..1	dateTime	When the annotation was made
text	Σ	1..1	markdown	The annotation - text content (as markdown) Required Pattern: population
variableRole	Σ	1..1	CodeableConcept	population | subpopulation | exposure | referenceExposure | measuredVariable | confounder Binding: EvidenceVariableRole (extensible): The role that the assertion variable plays.
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	Σ	0..*	Coding	Code defined by a terminology system
text	Σ	0..1	string	Plain text representation of the concept Required Pattern: Use extension:variableRoleCode instead.
observed	Σ	0..1	Reference(StudyGroup | ExposureGroup | ComparatorGroup | MetaanalysisStudyGroup)	Definition of the actual variable related to the statistic(s)
intended		0..1	Reference(Group)	Definition of the intended variable related to the Evidence
directnessMatch		0..1	CodeableConcept	low | moderate | high | exact Binding: EvidenceDirectness (extensible): The quality of how direct the match is.
variableDefinition:exposure		1..1	BackboneElement	Evidence variable such as population, exposure, or outcome
id		0..1	string	Unique id for inter-element referencing
Slices for extension		2..*	Extension	Extension Slice: Unordered, Open by value:url
variableRoleCode		1..1	(Complex)	population | exposure | outcome | covariate URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code
id		0..1	id	Unique id for inter-element referencing
extension		0..0
url		1..1	uri	"http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code"
value[x]		0..1	code	Value of extension Required Pattern: exposure
roleSubtype		0..1	CodeableConcept	subgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-role-subtype Binding: EvidenceVariableRoleSubtype Value Set (extensible)
comparatorCategory		1..1	string	The reference value used for comparison URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-comparator-category
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	A text description or summary of the variable
note		0..*	Annotation	Footnotes and/or explanatory notes
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
author[x]	Σ	0..1		Individual responsible for the annotation
authorReference			Reference(Practitioner | PractitionerRole | Patient | RelatedPerson | Organization)
authorString			string
time	Σ	0..1	dateTime	When the annotation was made
text	Σ	1..1	markdown	The annotation - text content (as markdown) Required Pattern: exposure
variableRole	Σ	1..1	CodeableConcept	population | subpopulation | exposure | referenceExposure | measuredVariable | confounder Binding: EvidenceVariableRole (extensible): The role that the assertion variable plays.
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	Σ	0..*	Coding	Code defined by a terminology system
text	Σ	0..1	string	Plain text representation of the concept Required Pattern: Use extension:variableRoleCode instead.
observed	Σ	0..1	Reference(GroupAssignment)	Definition of the actual variable related to the statistic(s)
intended		0..1	Reference(VariableDefinition)	Definition of the intended variable related to the Evidence
directnessMatch		0..1	CodeableConcept	low | moderate | high | exact Binding: EvidenceDirectness (extensible): The quality of how direct the match is.
variableDefinition:outcome	S	1..*	BackboneElement	Evidence variable such as population, exposure, or outcome
id		0..1	string	Unique id for inter-element referencing
Slices for extension		1..*	Extension	Extension Slice: Unordered, Open by value:url
variableRoleCode		1..1	(Complex)	population | exposure | outcome | covariate URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code
id		0..1	id	Unique id for inter-element referencing
extension		0..0
url		1..1	uri	"http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code"
value[x]		0..1	code	Value of extension Required Pattern: outcome
roleSubtype		0..1	CodeableConcept	subgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-role-subtype Binding: EvidenceVariableRoleSubtype Value Set (extensible)
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	A text description or summary of the variable
note		0..*	Annotation	Footnotes and/or explanatory notes
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
author[x]	Σ	0..1		Individual responsible for the annotation
authorReference			Reference(Practitioner | PractitionerRole | Patient | RelatedPerson | Organization)
authorString			string
time	Σ	0..1	dateTime	When the annotation was made
text	Σ	1..1	markdown	The annotation - text content (as markdown) Required Pattern: outcome
variableRole	Σ	1..1	CodeableConcept	population | subpopulation | exposure | referenceExposure | measuredVariable | confounder Binding: EvidenceVariableRole (extensible): The role that the assertion variable plays.
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	Σ	0..*	Coding	Code defined by a terminology system
text	Σ	0..1	string	Plain text representation of the concept Required Pattern: Use extension:variableRoleCode instead.
observed	Σ	0..1	Reference(VariableDefinition)	Definition of the actual variable related to the statistic(s)
intended		0..1	Reference(EvidenceVariable)	Definition of the intended variable related to the Evidence
directnessMatch		0..1	CodeableConcept	low | moderate | high | exact Binding: EvidenceDirectness (extensible): The quality of how direct the match is.
variableDefinition:covariate		1..*	BackboneElement	Evidence variable such as population, exposure, or outcome
id		0..1	string	Unique id for inter-element referencing
Slices for extension		1..*	Extension	Extension Slice: Unordered, Open by value:url
variableRoleCode		1..1	(Complex)	population | exposure | outcome | covariate URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code
id		0..1	id	Unique id for inter-element referencing
extension		0..0
url		1..1	uri	"http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code"
value[x]		0..1	code	Value of extension Required Pattern: covariate
roleSubtype		0..1	(Complex)	subgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-role-subtype
id		0..1	id	Unique id for inter-element referencing
extension		0..0
url		1..1	uri	"http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-role-subtype"
value[x]		0..1	CodeableConcept	Value of extension Binding: EvidenceVariableRoleSubtype Value Set (extensible)
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	Σ	0..*	Coding	Code defined by a terminology system
text	Σ	0..1	string	Plain text representation of the concept Required Pattern: Relative Value Multiplier
comparatorCategory		0..1	string	The reference value used for comparison URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-comparator-category
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	A text description or summary of the variable
note		0..*	Annotation	Footnotes and/or explanatory notes
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
author[x]	Σ	0..1		Individual responsible for the annotation
authorReference			Reference(Practitioner | PractitionerRole | Patient | RelatedPerson | Organization)
authorString			string
time	Σ	0..1	dateTime	When the annotation was made
text	Σ	1..1	markdown	The annotation - text content (as markdown) Required Pattern: covariate
variableRole	Σ	1..1	CodeableConcept	population | subpopulation | exposure | referenceExposure | measuredVariable | confounder Binding: EvidenceVariableRole (extensible): The role that the assertion variable plays.
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	Σ	0..*	Coding	Code defined by a terminology system
text	Σ	0..1	string	Plain text representation of the concept Required Pattern: Use extension:variableRoleCode instead.
observed	Σ	0..1	Reference(Group | EvidenceVariable)	Definition of the actual variable related to the statistic(s)
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
reference	ΣC	0..1	string	Literal reference, Relative, internal or absolute URL
type	Σ	0..1	uri	Type the reference refers to (e.g. "Patient") - must be a resource in resources Binding: ResourceType (extensible): Aa resource (or, for logical models, the URI of the logical model).
identifier	ΣC	0..1	Identifier	Logical reference, when literal reference is not known
display	ΣC	0..1	string	Text alternative for the resource Required Pattern: Relative Importance Multiplier
directnessMatch		0..1	CodeableConcept	low | moderate | high | exact Binding: EvidenceDirectness (extensible): The quality of how direct the match is.
synthesisType		0..1	CodeableConcept	The method to combine studies Binding: StatisticSynthesisType (extensible): Types of combining results from a body of evidence (e.g. summary data meta-analysis).
studyDesign		0..*	CodeableConcept	The design of the study that produced this evidence Binding: StudyDesign (extensible): This is a set of terms for study design characteristics.
Slices for statistic		1..*	BackboneElement	Values and parameters for a single statistic Slice: Unordered, Open by value:statisticType.coding
statistic:All Slices				Content/Rules for all slices
id		0..1	string	Unique id for inter-element referencing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
modelExpression		0..1	Expression	The formula for analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-expression
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	Description of content
note		0..*	Annotation	Footnotes and/or explanatory notes
statisticType		0..1	CodeableConcept	Type of statistic, e.g., relative risk Binding: StatisticType (extensible)
category		0..1	CodeableConcept	Associated category for categorical variable
quantity		0..1	Quantity	Statistic value
numberOfEvents		0..1	unsignedInt	The number of events associated with the statistic
numberAffected		0..1	unsignedInt	The number of participants affected
sampleSize		0..1	BackboneElement	Number of samples in the statistic
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	Textual description of sample size for statistic
note		0..*	Annotation	Footnote or explanatory note about the sample size
numberOfStudies		0..1	unsignedInt	Number of contributing studies
numberOfParticipants		0..1	unsignedInt	Cumulative number of participants
knownDataCount		0..1	unsignedInt	Number of participants with known results for measured variables
attributeEstimate		0..*	BackboneElement	An attribute of the Statistic
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	Textual description of the attribute estimate
note		0..*	Annotation	Footnote or explanatory note about the estimate
type		0..1	CodeableConcept	The type of attribute estimate, e.g., confidence interval or p value Binding: AttributeEstimateType (extensible)
quantity		0..1	Quantity	The singular quantity of the attribute estimate, for attribute estimates represented as single values; also used to report unit of measure
level		0..1	decimal	Level of confidence interval, e.g., 0.95 for 95% confidence interval
range		0..1	Range	Lower and upper bound values of the attribute estimate
attributeEstimate		0..*	See attributeEstimate (Evidence)	A nested attribute estimate; which is the attribute estimate of an attribute estimate
modelCharacteristic		0..*	BackboneElement	An aspect of the statistical model
id		0..1	string	Unique id for inter-element referencing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
valueQuantity		0..1	SimpleQuantity	Value as Quantity URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-quantity
valueRange		0..1	Range	Value as Range URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-range
valueCodeableConcept		0..1	CodeableConcept	Value as CodeableConcept URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-codeableconcept
intended		0..1	boolean	The plan for analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-intended
applied		0..1	boolean	The analysis that was applied URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-applied
includeIf		0..1	(Complex)	Condition upon which to include the variable or model characteristic in the analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-include-if
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
code		1..1	CodeableConcept	Model specification Binding: StatisticModelCode (extensible)
variable		0..*	BackboneElement	A variable adjusted for in the adjusted analysis
id		0..1	string	Unique id for inter-element referencing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
includeIf		0..1	(Complex)	Condition upon which to include the variable or model characteristic in the analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-include-if
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
variableDefinition		1..1	Reference(Group | EvidenceVariable)	Description of the variable
handling		0..1	code	continuous | dichotomous | ordinal | polychotomous Binding: EvidenceVariableHandling (required)
valueCategory		0..*	CodeableConcept	Description for grouping of ordinal or polychotomous variables
valueQuantity		0..*	Quantity	Discrete value for grouping of ordinal or polychotomous variables
valueRange		0..*	Range	Range of values for grouping of ordinal or polychotomous variables
attributeEstimate		0..*	See attributeEstimate (Evidence)	An attribute of the statistic used as a model characteristic
statistic:netEffect	S	1..1	BackboneElement	Values and parameters for a single statistic
id		0..1	string	Unique id for inter-element referencing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
modelExpression		0..1	Expression	The formula for analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-expression
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	Description of content
note		0..*	Annotation	Footnotes and/or explanatory notes
statisticType		0..1	CodeableConcept	Type of statistic, e.g., relative risk Binding: StatisticType (extensible)
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	Σ	1..1	Coding	Code defined by a terminology system Required Pattern: At least the following
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
system		1..1	uri	Identity of the terminology system Fixed Value: https://fevir.net/resources/CodeSystem/181513
version		0..1	string	Version of the system - if relevant
code		1..1	code	Symbol in syntax defined by the system Fixed Value: STATO:0000424
display		1..1	string	Representation defined by the system Fixed Value: Risk Difference
userSelected		0..1	boolean	If this coding was chosen directly by the user
text	Σ	0..1	string	Plain text representation of the concept
category		0..1	CodeableConcept	Associated category for categorical variable
quantity		0..1	Quantity	Statistic value
numberOfEvents		0..1	unsignedInt	The number of events associated with the statistic
numberAffected		0..1	unsignedInt	The number of participants affected
sampleSize		0..1	BackboneElement	Number of samples in the statistic
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	Textual description of sample size for statistic
note		0..*	Annotation	Footnote or explanatory note about the sample size
numberOfStudies		0..1	unsignedInt	Number of contributing studies
numberOfParticipants		0..1	unsignedInt	Cumulative number of participants
knownDataCount		0..1	unsignedInt	Number of participants with known results for measured variables
Slices for attributeEstimate		1..*	BackboneElement	An attribute of the Statistic Slice: Unordered, Open by value:type.coding
attributeEstimate:All Slices				Content/Rules for all slices
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	Textual description of the attribute estimate
note		0..*	Annotation	Footnote or explanatory note about the estimate
type		0..1	CodeableConcept	The type of attribute estimate, e.g., confidence interval or p value Binding: AttributeEstimateType (extensible)
quantity		0..1	Quantity	The singular quantity of the attribute estimate, for attribute estimates represented as single values; also used to report unit of measure
level		0..1	decimal	Level of confidence interval, e.g., 0.95 for 95% confidence interval
range		0..1	Range	Lower and upper bound values of the attribute estimate
attributeEstimate		0..*	See attributeEstimate (Evidence)	A nested attribute estimate; which is the attribute estimate of an attribute estimate
attributeEstimate:confidenceInterval	S	1..1	BackboneElement	An attribute of the Statistic
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	Textual description of the attribute estimate
note		0..*	Annotation	Footnote or explanatory note about the estimate
type		0..1	CodeableConcept	The type of attribute estimate, e.g., confidence interval or p value Binding: AttributeEstimateType (extensible)
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	Σ	1..1	Coding	Code defined by a terminology system Required Pattern: At least the following
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
system		1..1	uri	Identity of the terminology system Fixed Value: https://fevir.net/resources/CodeSystem/181513
version		0..1	string	Version of the system - if relevant
code		1..1	code	Symbol in syntax defined by the system Fixed Value: STATO:0000196
display		1..1	string	Representation defined by the system Fixed Value: confidence interval
userSelected		0..1	boolean	If this coding was chosen directly by the user
text	Σ	0..1	string	Plain text representation of the concept
quantity		0..1	Quantity	The singular quantity of the attribute estimate, for attribute estimates represented as single values; also used to report unit of measure
level		0..1	decimal	Level of confidence interval, e.g., 0.95 for 95% confidence interval
range		0..1	Range	Lower and upper bound values of the attribute estimate
attributeEstimate		0..*	See attributeEstimate (Evidence)	A nested attribute estimate; which is the attribute estimate of an attribute estimate
Slices for modelCharacteristic		1..*	BackboneElement	An aspect of the statistical model Slice: Unordered, Open by value:code.coding
modelCharacteristic:All Slices				Content/Rules for all slices
id		0..1	string	Unique id for inter-element referencing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
valueQuantity		0..1	SimpleQuantity	Value as Quantity URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-quantity
valueRange		0..1	Range	Value as Range URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-range
valueCodeableConcept		0..1	CodeableConcept	Value as CodeableConcept URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-codeableconcept
intended		0..1	boolean	The plan for analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-intended
applied		0..1	boolean	The analysis that was applied URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-applied
includeIf		0..1	(Complex)	Condition upon which to include the variable or model characteristic in the analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-include-if
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
code		1..1	CodeableConcept	Model specification Binding: StatisticModelCode (extensible)
variable		0..*	BackboneElement	A variable adjusted for in the adjusted analysis
id		0..1	string	Unique id for inter-element referencing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
includeIf		0..1	(Complex)	Condition upon which to include the variable or model characteristic in the analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-include-if
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
variableDefinition		1..1	Reference(Group | EvidenceVariable)	Description of the variable
handling		0..1	code	continuous | dichotomous | ordinal | polychotomous Binding: EvidenceVariableHandling (required)
valueCategory		0..*	CodeableConcept	Description for grouping of ordinal or polychotomous variables
valueQuantity		0..*	Quantity	Discrete value for grouping of ordinal or polychotomous variables
valueRange		0..*	Range	Range of values for grouping of ordinal or polychotomous variables
attributeEstimate		0..*	See attributeEstimate (Evidence)	An attribute of the statistic used as a model characteristic
modelCharacteristic:netEffectContributionAnalysis	S	1..1	BackboneElement	An aspect of the statistical model
id		0..1	string	Unique id for inter-element referencing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
valueQuantity		0..1	SimpleQuantity	Value as Quantity URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-quantity
valueRange		0..1	Range	Value as Range URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-range
valueCodeableConcept		0..1	CodeableConcept	Value as CodeableConcept URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-codeableconcept
intended		0..1	boolean	The plan for analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-intended
applied		0..1	boolean	The analysis that was applied URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-applied
includeIf		0..1	(Complex)	Condition upon which to include the variable or model characteristic in the analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-include-if
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
code		1..1	CodeableConcept	Model specification Binding: StatisticModelCode (extensible)
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	Σ	1..1	Coding	Code defined by a terminology system Required Pattern: At least the following
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
system		1..1	uri	Identity of the terminology system Fixed Value: https://fevir.net/resources/CodeSystem/181513
version		0..1	string	Version of the system - if relevant
code		1..1	code	Symbol in syntax defined by the system Fixed Value: TBD:net-effect-contribution-analysis
display		1..1	string	Representation defined by the system Fixed Value: Net effect contribution analysis
userSelected		0..1	boolean	If this coding was chosen directly by the user
text	Σ	0..1	string	Plain text representation of the concept
variable		0..*	BackboneElement	A variable adjusted for in the adjusted analysis
id		0..1	string	Unique id for inter-element referencing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
includeIf		0..1	(Complex)	Condition upon which to include the variable or model characteristic in the analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-include-if
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
variableDefinition		1..1	Reference(Group | EvidenceVariable)	Description of the variable
handling		0..1	code	continuous | dichotomous | ordinal | polychotomous Binding: EvidenceVariableHandling (required)
valueCategory		0..*	CodeableConcept	Description for grouping of ordinal or polychotomous variables
valueQuantity		0..*	Quantity	Discrete value for grouping of ordinal or polychotomous variables
valueRange		0..*	Range	Range of values for grouping of ordinal or polychotomous variables
attributeEstimate		0..*	See attributeEstimate (Evidence)	An attribute of the statistic used as a model characteristic
certainty		0..*	BackboneElement	Certainty or quality of the evidence
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	Textual description of certainty
note		0..*	Annotation	Footnotes and/or explanatory notes
type		0..1	CodeableConcept	Aspect of certainty being rated Binding: EvidenceCertaintyType (extensible): The aspect of quality, confidence, or certainty.
rating		0..1	CodeableConcept	Assessment or judgement of the aspect Binding: EvidenceCertaintyRating (extensible): The assessment of quality, confidence, or certainty.
rater		0..1	string	Individual or group who did the rating
subcomponent		0..*	See certainty (Evidence)	A domain or subdomain of certainty
Documentation for this format

Terminology Bindings

Path	Conformance	ValueSet / Code	URI
Evidence.language	required	AllLanguages http://hl7.org/fhir/ValueSet/all-languages|5.0.0 from the FHIR Standard
Evidence.versionAlgorithm[x]	extensible	VersionAlgorithm http://hl7.org/fhir/ValueSet/version-algorithm from the FHIR Standard
Evidence.status	required	PublicationStatus http://hl7.org/fhir/ValueSet/publication-status|5.0.0 from the FHIR Standard
Evidence.relatedArtifact:amendedWith.type	required	Pattern: amended-with http://hl7.org/fhir/ValueSet/related-artifact-type|5.0.0 from the FHIR Standard
Evidence.relatedArtifact:amendedWith.classifier	example	CitationArtifactClassifier http://hl7.org/fhir/ValueSet/citation-artifact-classifier from the FHIR Standard
Evidence.relatedArtifact:amendedWith.publicationStatus	required	PublicationStatus http://hl7.org/fhir/ValueSet/publication-status|5.0.0 from the FHIR Standard
Evidence.relatedArtifact:citeAs.type	required	Pattern: cite-as http://hl7.org/fhir/ValueSet/related-artifact-type|5.0.0 from the FHIR Standard
Evidence.relatedArtifact:citeAs.classifier	example	CitationArtifactClassifier http://hl7.org/fhir/ValueSet/citation-artifact-classifier from the FHIR Standard
Evidence.relatedArtifact:citeAs.publicationStatus	required	PublicationStatus http://hl7.org/fhir/ValueSet/publication-status|5.0.0 from the FHIR Standard
Evidence.variableDefinition.variableRole	extensible	EvidenceVariableRole http://hl7.org/fhir/ValueSet/variable-role from the FHIR Standard
Evidence.variableDefinition.directnessMatch	extensible	EvidenceDirectness http://terminology.hl7.org/ValueSet/directness
Evidence.variableDefinition:population.variableRole	extensible	EvidenceVariableRole http://hl7.org/fhir/ValueSet/variable-role from the FHIR Standard
Evidence.variableDefinition:population.directnessMatch	extensible	EvidenceDirectness http://terminology.hl7.org/ValueSet/directness
Evidence.variableDefinition:exposure.variableRole	extensible	EvidenceVariableRole http://hl7.org/fhir/ValueSet/variable-role from the FHIR Standard
Evidence.variableDefinition:exposure.directnessMatch	extensible	EvidenceDirectness http://terminology.hl7.org/ValueSet/directness
Evidence.variableDefinition:outcome.variableRole	extensible	EvidenceVariableRole http://hl7.org/fhir/ValueSet/variable-role from the FHIR Standard
Evidence.variableDefinition:outcome.directnessMatch	extensible	EvidenceDirectness http://terminology.hl7.org/ValueSet/directness
Evidence.variableDefinition:covariate.extension:roleSubtype.value[x]	extensible	Evidence_variable_role_subtype https://fevir.net/resources/ValueSet/179424 from this IG
Evidence.variableDefinition:covariate.variableRole	extensible	EvidenceVariableRole http://hl7.org/fhir/ValueSet/variable-role from the FHIR Standard
Evidence.variableDefinition:covariate.observed.type	extensible	ResourceType http://hl7.org/fhir/ValueSet/resource-types from the FHIR Standard
Evidence.variableDefinition:covariate.directnessMatch	extensible	EvidenceDirectness http://terminology.hl7.org/ValueSet/directness
Evidence.synthesisType	extensible	StatisticSynthesisType http://terminology.hl7.org/ValueSet/synthesis-type
Evidence.studyDesign	extensible	StudyDesign http://hl7.org/fhir/ValueSet/study-design from the FHIR Standard
Evidence.statistic.statisticType	extensible	StatisticType http://hl7.org/fhir/ValueSet/statistic-type from the FHIR Standard
Evidence.statistic.attributeEstimate.type	extensible	AttributeEstimateType http://hl7.org/fhir/ValueSet/attribute-estimate-type from the FHIR Standard
Evidence.statistic.modelCharacteristic.code	extensible	StatisticModelCode http://hl7.org/fhir/ValueSet/statistic-model-code from the FHIR Standard
Evidence.statistic.modelCharacteristic.variable.handling	required	EvidenceVariableHandling http://hl7.org/fhir/ValueSet/variable-handling|5.0.0 from the FHIR Standard
Evidence.statistic:netEffect.statisticType	extensible	StatisticType http://hl7.org/fhir/ValueSet/statistic-type from the FHIR Standard
Evidence.statistic:netEffect.attributeEstimate.type	extensible	AttributeEstimateType http://hl7.org/fhir/ValueSet/attribute-estimate-type from the FHIR Standard
Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.type	extensible	AttributeEstimateType http://hl7.org/fhir/ValueSet/attribute-estimate-type from the FHIR Standard
Evidence.statistic:netEffect.modelCharacteristic.code	extensible	StatisticModelCode http://hl7.org/fhir/ValueSet/statistic-model-code from the FHIR Standard
Evidence.statistic:netEffect.modelCharacteristic.variable.handling	required	EvidenceVariableHandling http://hl7.org/fhir/ValueSet/variable-handling|5.0.0 from the FHIR Standard
Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.code	extensible	StatisticModelCode http://hl7.org/fhir/ValueSet/statistic-model-code from the FHIR Standard
Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.variable.handling	required	EvidenceVariableHandling http://hl7.org/fhir/ValueSet/variable-handling|5.0.0 from the FHIR Standard
Evidence.certainty.type	extensible	EvidenceCertaintyType http://hl7.org/fhir/ValueSet/certainty-type from the FHIR Standard
Evidence.certainty.rating	extensible	EvidenceCertaintyRating http://hl7.org/fhir/ValueSet/certainty-rating from the FHIR Standard

Constraints

Id	Grade	Path(s)	Details	Requirements
cnl-0	warning	Evidence	Name should be usable as an identifier for the module by machine processing applications such as code generation : name.exists() implies name.matches('^[A-Z]([A-Za-z0-9_]){1,254}$')
cnl-1	warning	Evidence.url	URL should not contain | or # - these characters make processing canonical references problematic : exists() implies matches('^[^|# ]+$')
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children : hasValue() or (children().count() > id.count())
ext-1	error	**ALL** extensions	Must have either extensions or value[x], not both : extension.exists() != value.exists()

This structure is derived from ComparativeEvidence

Summary

Mandatory: 10 elements(2 nested mandatory elements)
Must-Support: 4 elements
Prohibited: 1 element

Structures

This structure refers to these other structures:

• OutcomeImportance (http://hl7.org/fhir/uv/ebm/StructureDefinition/outcome-importance)

Slices

This structure defines the following Slices:

• The element 1 is sliced based on the value of Evidence.relatedArtifact
• The element 1 is sliced based on the value of Evidence.statistic
• The element 1 is sliced based on the value of Evidence.statistic.attributeEstimate
• The element 1 is sliced based on the value of Evidence.statistic.modelCharacteristic

Maturity: 1

Differential View

This structure is derived from ComparativeEvidence

Name	Flags	Card.	Type	Description & Constraints
Evidence			ComparativeEvidence
Slices for relatedArtifact		1..*	RelatedArtifact	Link or citation to artifact associated with the summary Slice: Unordered, Open by value:type
relatedArtifact:amendedWith	S	1..*	RelatedArtifact	Link or citation to artifact associated with the summary
type		1..1	code	documentation | justification | citation | predecessor | successor | derived-from | depends-on | composed-of | part-of | amends | amended-with | appends | appended-with | cites | cited-by | comments-on | comment-in | contains | contained-in | corrects | correction-in | replaces | replaced-with | retracts | retracted-by | signs | similar-to | supports | supported-with | transforms | transformed-into | transformed-with | documents | specification-of | created-with | cite-as Required Pattern: amended-with
resourceReference		0..1	Reference(OutcomeImportance)	What artifact, if not a conformance resource
relatedArtifact:citeAs		0..1	RelatedArtifact	Link or citation to artifact associated with the summary
type		1..1	code	documentation | justification | citation | predecessor | successor | derived-from | depends-on | composed-of | part-of | amends | amended-with | appends | appended-with | cites | cited-by | comments-on | comment-in | contains | contained-in | corrects | correction-in | replaces | replaced-with | retracts | retracted-by | signs | similar-to | supports | supported-with | transforms | transformed-into | transformed-with | documents | specification-of | created-with | cite-as Required Pattern: cite-as
variableDefinition		4..*	BackboneElement	Evidence variable such as population, exposure, or outcome
variableDefinition:covariate		1..*	BackboneElement	Evidence variable such as population, exposure, or outcome
extension:variableRoleCode		1..1	VariableDefinitionVariableRoleCode	population | exposure | outcome | covariate
value[x]		0..1	code	Value of extension Required Pattern: covariate
extension:roleSubtype		0..1	VariableDefinitionRoleSubtype	subgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier
value[x]
text		0..1	string	Plain text representation of the concept Required Pattern: Relative Value Multiplier
extension:comparatorCategory		0..1	VariableDefinitionComparatorCategory	The reference value used for comparison
note
text		1..1	markdown	The annotation - text content (as markdown) Required Pattern: covariate
observed
display		0..1	string	Text alternative for the resource Required Pattern: Relative Importance Multiplier
intended		0..0
Slices for statistic		1..*	BackboneElement	Values and parameters for a single statistic Slice: Unordered, Open by value:statisticType.coding
statistic:netEffect	S	1..1	BackboneElement	Values and parameters for a single statistic
extension:modelExpression		0..1	StatisticModelExpression	The formula for analysis
statisticType
coding		1..1	Coding	Code defined by a terminology system Required Pattern: At least the following
system		1..1	uri	Identity of the terminology system Fixed Value: https://fevir.net/resources/CodeSystem/181513
code		1..1	code	Symbol in syntax defined by the system Fixed Value: STATO:0000424
display		1..1	string	Representation defined by the system Fixed Value: Risk Difference
Slices for attributeEstimate		1..*	BackboneElement	An attribute of the Statistic Slice: Unordered, Open by value:type.coding
attributeEstimate:confidenceInterval	S	1..1	BackboneElement	An attribute of the Statistic
type
coding		1..1	Coding	Code defined by a terminology system Required Pattern: At least the following
system		1..1	uri	Identity of the terminology system Fixed Value: https://fevir.net/resources/CodeSystem/181513
code		1..1	code	Symbol in syntax defined by the system Fixed Value: STATO:0000196
display		1..1	string	Representation defined by the system Fixed Value: confidence interval
Slices for modelCharacteristic		1..*	BackboneElement	An aspect of the statistical model Slice: Unordered, Open by value:code.coding
modelCharacteristic:All Slices				Content/Rules for all slices
extension:valueQuantity		0..1	StatisticModelValueQuantity	Value as Quantity
extension:valueRange		0..1	StatisticModelValueRange	Value as Range
extension:valueCodeableConcept		0..1	StatisticModelValueCodeableConcept	Value as CodeableConcept
extension:intended		0..1	StatisticModelIntended	The plan for analysis
extension:applied		0..1	StatisticModelApplied	The analysis that was applied
extension:includeIf		0..1	StatisticModelIncludeIf	Condition upon which to include the variable or model characteristic in the analysis
variable
extension:includeIf		0..1	StatisticModelIncludeIf	Condition upon which to include the variable or model characteristic in the analysis
modelCharacteristic:netEffectContributionAnalysis	S	1..1	BackboneElement	An aspect of the statistical model
extension:valueQuantity		0..1	StatisticModelValueQuantity	Value as Quantity
extension:valueRange		0..1	StatisticModelValueRange	Value as Range
extension:valueCodeableConcept		0..1	StatisticModelValueCodeableConcept	Value as CodeableConcept
extension:intended		0..1	StatisticModelIntended	The plan for analysis
extension:applied		0..1	StatisticModelApplied	The analysis that was applied
extension:includeIf		0..1	StatisticModelIncludeIf	Condition upon which to include the variable or model characteristic in the analysis
code
coding		1..1	Coding	Code defined by a terminology system Required Pattern: At least the following
system		1..1	uri	Identity of the terminology system Fixed Value: https://fevir.net/resources/CodeSystem/181513
code		1..1	code	Symbol in syntax defined by the system Fixed Value: TBD:net-effect-contribution-analysis
display		1..1	string	Representation defined by the system Fixed Value: Net effect contribution analysis
variable
extension:includeIf		0..1	StatisticModelIncludeIf	Condition upon which to include the variable or model characteristic in the analysis
Documentation for this format

Key Elements View

Name	Flags	Card.	Type	Description & Constraints
Evidence	C	0..*	ComparativeEvidence	Single evidence bit cnl-0: Name should be usable as an identifier for the module by machine processing applications such as code generation
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
contained		0..*	Resource	Contained, inline Resources
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored
status	?!Σ	1..1	code	draft | active | retired | unknown Binding: PublicationStatus (required): The lifecycle status of an artifact.
Slices for relatedArtifact		1..*	RelatedArtifact	Link or citation to artifact associated with the summary Slice: Unordered, Open by value:type
relatedArtifact:amendedWith	S	1..*	RelatedArtifact	Link or citation to artifact associated with the summary
type	Σ	1..1	code	documentation | justification | citation | predecessor | successor | derived-from | depends-on | composed-of | part-of | amends | amended-with | appends | appended-with | cites | cited-by | comments-on | comment-in | contains | contained-in | corrects | correction-in | replaces | replaced-with | retracts | retracted-by | signs | similar-to | supports | supported-with | transforms | transformed-into | transformed-with | documents | specification-of | created-with | cite-as Binding: RelatedArtifactType (required): The type of relationship to the related artifact. Required Pattern: amended-with
resourceReference	Σ	0..1	Reference(OutcomeImportance)	What artifact, if not a conformance resource
relatedArtifact:citeAs		0..1	RelatedArtifact	Link or citation to artifact associated with the summary
type	Σ	1..1	code	documentation | justification | citation | predecessor | successor | derived-from | depends-on | composed-of | part-of | amends | amended-with | appends | appended-with | cites | cited-by | comments-on | comment-in | contains | contained-in | corrects | correction-in | replaces | replaced-with | retracts | retracted-by | signs | similar-to | supports | supported-with | transforms | transformed-into | transformed-with | documents | specification-of | created-with | cite-as Binding: RelatedArtifactType (required): The type of relationship to the related artifact. Required Pattern: cite-as
Slices for variableDefinition		4..*	BackboneElement	Evidence variable such as population, exposure, or outcome Slice: Unordered, Open by value:note.text
variableDefinition:All Slices				Content/Rules for all slices
Slices for extension		1..*	Extension	Extension Slice: Unordered, Open by value:url
variableRoleCode		1..1	code	population | exposure | outcome | covariate URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code
roleSubtype		0..1	CodeableConcept	subgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-role-subtype Binding: EvidenceVariableRoleSubtype Value Set (extensible)
comparatorCategory		0..1	string	The reference value used for comparison URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-comparator-category
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
variableRole	Σ	1..1	CodeableConcept	population | subpopulation | exposure | referenceExposure | measuredVariable | confounder Binding: EvidenceVariableRole (extensible): The role that the assertion variable plays.
variableDefinition:population		1..*	BackboneElement	Evidence variable such as population, exposure, or outcome
Slices for extension		1..*	Extension	Extension Slice: Unordered, Open by value:url
variableRoleCode		1..1	(Complex)	population | exposure | outcome | covariate URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code
extension		0..0
url		1..1	uri	"http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code"
roleSubtype		0..1	CodeableConcept	subgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-role-subtype Binding: EvidenceVariableRoleSubtype Value Set (extensible)
comparatorCategory		0..1	string	The reference value used for comparison URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-comparator-category
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
variableRole	Σ	1..1	CodeableConcept	population | subpopulation | exposure | referenceExposure | measuredVariable | confounder Binding: EvidenceVariableRole (extensible): The role that the assertion variable plays.
variableDefinition:exposure		1..1	BackboneElement	Evidence variable such as population, exposure, or outcome
Slices for extension		2..*	Extension	Extension Slice: Unordered, Open by value:url
variableRoleCode		1..1	(Complex)	population | exposure | outcome | covariate URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code
extension		0..0
url		1..1	uri	"http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code"
roleSubtype		0..1	CodeableConcept	subgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-role-subtype Binding: EvidenceVariableRoleSubtype Value Set (extensible)
comparatorCategory		1..1	string	The reference value used for comparison URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-comparator-category
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
variableRole	Σ	1..1	CodeableConcept	population | subpopulation | exposure | referenceExposure | measuredVariable | confounder Binding: EvidenceVariableRole (extensible): The role that the assertion variable plays.
variableDefinition:outcome	S	1..*	BackboneElement	Evidence variable such as population, exposure, or outcome
Slices for extension		1..*	Extension	Extension Slice: Unordered, Open by value:url
variableRoleCode		1..1	(Complex)	population | exposure | outcome | covariate URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code
extension		0..0
url		1..1	uri	"http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code"
roleSubtype		0..1	CodeableConcept	subgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-role-subtype Binding: EvidenceVariableRoleSubtype Value Set (extensible)
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
variableRole	Σ	1..1	CodeableConcept	population | subpopulation | exposure | referenceExposure | measuredVariable | confounder Binding: EvidenceVariableRole (extensible): The role that the assertion variable plays.
variableDefinition:covariate		1..*	BackboneElement	Evidence variable such as population, exposure, or outcome
Slices for extension		1..*	Extension	Extension Slice: Unordered, Open by value:url
variableRoleCode		1..1	(Complex)	population | exposure | outcome | covariate URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code
extension		0..0
url		1..1	uri	"http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code"
value[x]		0..1	code	Value of extension Required Pattern: covariate
roleSubtype		0..1	(Complex)	subgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-role-subtype
extension		0..0
url		1..1	uri	"http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-role-subtype"
comparatorCategory		0..1	string	The reference value used for comparison URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-comparator-category
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
variableRole	Σ	1..1	CodeableConcept	population | subpopulation | exposure | referenceExposure | measuredVariable | confounder Binding: EvidenceVariableRole (extensible): The role that the assertion variable plays.
Slices for statistic		1..*	BackboneElement	Values and parameters for a single statistic Slice: Unordered, Open by value:statisticType.coding
statistic:All Slices				Content/Rules for all slices
modelExpression		0..1	Expression	The formula for analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-expression
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
statistic:netEffect	S	1..1	BackboneElement	Values and parameters for a single statistic
modelExpression		0..1	Expression	The formula for analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-expression
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
Slices for attributeEstimate		1..*	BackboneElement	An attribute of the Statistic Slice: Unordered, Open by value:type.coding
attributeEstimate:All Slices				Content/Rules for all slices
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
attributeEstimate:confidenceInterval	S	1..1	BackboneElement	An attribute of the Statistic
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
Slices for modelCharacteristic		1..*	BackboneElement	An aspect of the statistical model Slice: Unordered, Open by value:code.coding
modelCharacteristic:All Slices				Content/Rules for all slices
valueQuantity		0..1	SimpleQuantity	Value as Quantity URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-quantity
valueRange		0..1	Range	Value as Range URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-range
valueCodeableConcept		0..1	CodeableConcept	Value as CodeableConcept URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-codeableconcept
intended		0..1	boolean	The plan for analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-intended
applied		0..1	boolean	The analysis that was applied URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-applied
includeIf		0..1	(Complex)	Condition upon which to include the variable or model characteristic in the analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-include-if
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
code		1..1	CodeableConcept	Model specification Binding: StatisticModelCode (extensible)
modelCharacteristic:netEffectContributionAnalysis	S	1..1	BackboneElement	An aspect of the statistical model
valueQuantity		0..1	SimpleQuantity	Value as Quantity URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-quantity
valueRange		0..1	Range	Value as Range URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-range
valueCodeableConcept		0..1	CodeableConcept	Value as CodeableConcept URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-codeableconcept
intended		0..1	boolean	The plan for analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-intended
applied		0..1	boolean	The analysis that was applied URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-applied
includeIf		0..1	(Complex)	Condition upon which to include the variable or model characteristic in the analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-include-if
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
code		1..1	CodeableConcept	Model specification Binding: StatisticModelCode (extensible)
coding	Σ	1..1	Coding	Code defined by a terminology system Required Pattern: At least the following
system		1..1	uri	Identity of the terminology system Fixed Value: https://fevir.net/resources/CodeSystem/181513
code		1..1	code	Symbol in syntax defined by the system Fixed Value: TBD:net-effect-contribution-analysis
display		1..1	string	Representation defined by the system Fixed Value: Net effect contribution analysis
Documentation for this format

Terminology Bindings

Path	Conformance	ValueSet / Code	URI
Evidence.status	required	PublicationStatus http://hl7.org/fhir/ValueSet/publication-status|5.0.0 from the FHIR Standard
Evidence.relatedArtifact:amendedWith.type	required	Pattern: amended-with http://hl7.org/fhir/ValueSet/related-artifact-type|5.0.0 from the FHIR Standard
Evidence.relatedArtifact:citeAs.type	required	Pattern: cite-as http://hl7.org/fhir/ValueSet/related-artifact-type|5.0.0 from the FHIR Standard
Evidence.variableDefinition.variableRole	extensible	EvidenceVariableRole http://hl7.org/fhir/ValueSet/variable-role from the FHIR Standard
Evidence.variableDefinition:population.variableRole	extensible	EvidenceVariableRole http://hl7.org/fhir/ValueSet/variable-role from the FHIR Standard
Evidence.variableDefinition:exposure.variableRole	extensible	EvidenceVariableRole http://hl7.org/fhir/ValueSet/variable-role from the FHIR Standard
Evidence.variableDefinition:outcome.variableRole	extensible	EvidenceVariableRole http://hl7.org/fhir/ValueSet/variable-role from the FHIR Standard
Evidence.variableDefinition:covariate.variableRole	extensible	EvidenceVariableRole http://hl7.org/fhir/ValueSet/variable-role from the FHIR Standard
Evidence.statistic:netEffect.modelCharacteristic.code	extensible	StatisticModelCode http://hl7.org/fhir/ValueSet/statistic-model-code from the FHIR Standard
Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.code	extensible	StatisticModelCode http://hl7.org/fhir/ValueSet/statistic-model-code from the FHIR Standard

Constraints

Id	Grade	Path(s)	Details	Requirements
cnl-0	warning	Evidence	Name should be usable as an identifier for the module by machine processing applications such as code generation : name.exists() implies name.matches('^[A-Z]([A-Za-z0-9_]){1,254}$')
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children : hasValue() or (children().count() > id.count())
ext-1	error	**ALL** extensions	Must have either extensions or value[x], not both : extension.exists() != value.exists()

Snapshot View

Name	Flags	Card.	Type	Description & Constraints
Evidence	C	0..*	ComparativeEvidence	Single evidence bit cnl-0: Name should be usable as an identifier for the module by machine processing applications such as code generation
id	Σ	0..1	id	Logical id of this artifact
meta	Σ	0..1	Meta	Metadata about the resource
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
language		0..1	code	Language of the resource content Binding: AllLanguages (required): IETF language tag for a human language Additional Bindings Purpose CommonLanguages Starter Set
text		0..1	Narrative	Text summary of the resource, for human interpretation
contained		0..*	Resource	Contained, inline Resources
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored
url	ΣC	0..1	uri	Canonical identifier for this evidence, represented as a globally unique URI cnl-1: URL should not contain | or # - these characters make processing canonical references problematic
identifier	Σ	0..*	Identifier	Additional identifier for the summary
version	Σ	0..1	string	Business version of this summary
versionAlgorithm[x]	Σ	0..1		How to compare versions Binding: VersionAlgorithm (extensible)
versionAlgorithmString			string
versionAlgorithmCoding			Coding
name	C	0..1	string	Name for this summary (machine friendly)
title	Σ	0..1	string	Name for this summary (human friendly)
citeAs[x]		0..1		Citation for this evidence
citeAsReference			Reference(Citation)
citeAsMarkdown			markdown
status	?!Σ	1..1	code	draft | active | retired | unknown Binding: PublicationStatus (required): The lifecycle status of an artifact.
experimental		0..1	boolean	For testing purposes, not real usage
date	Σ	0..1	dateTime	Date last changed
approvalDate		0..1	date	When the summary was approved by publisher
lastReviewDate		0..1	date	When the summary was last reviewed by the publisher
publisher	Σ	0..1	string	Name of the publisher/steward (organization or individual)
contact	Σ	0..*	ContactDetail	Contact details for the publisher
author	Σ	0..*	ContactDetail	Who authored the content
editor		0..*	ContactDetail	Who edited the content
reviewer		0..*	ContactDetail	Who reviewed the content
endorser	Σ	0..*	ContactDetail	Who endorsed the content
useContext	Σ	0..*	UsageContext	The context that the content is intended to support
purpose		0..1	markdown	Why this Evidence is defined
copyright		0..1	markdown	Use and/or publishing restrictions
copyrightLabel		0..1	string	Copyright holder and year(s)
Slices for relatedArtifact		1..*	RelatedArtifact	Link or citation to artifact associated with the summary Slice: Unordered, Open by value:type
relatedArtifact:amendedWith	S	1..*	RelatedArtifact	Link or citation to artifact associated with the summary
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
type	Σ	1..1	code	documentation | justification | citation | predecessor | successor | derived-from | depends-on | composed-of | part-of | amends | amended-with | appends | appended-with | cites | cited-by | comments-on | comment-in | contains | contained-in | corrects | correction-in | replaces | replaced-with | retracts | retracted-by | signs | similar-to | supports | supported-with | transforms | transformed-into | transformed-with | documents | specification-of | created-with | cite-as Binding: RelatedArtifactType (required): The type of relationship to the related artifact. Required Pattern: amended-with
classifier	Σ	0..*	CodeableConcept	Additional classifiers Binding: CitationArtifactClassifier (example): Additional classifiers for the related artifact.
label	Σ	0..1	string	Short label
display	Σ	0..1	string	Brief description of the related artifact
citation	Σ	0..1	markdown	Bibliographic citation for the artifact
document	Σ	0..1	Attachment	What document is being referenced
resource	Σ	0..1	canonical(Resource)	What artifact is being referenced
resourceReference	Σ	0..1	Reference(OutcomeImportance)	What artifact, if not a conformance resource
publicationStatus	Σ	0..1	code	draft | active | retired | unknown Binding: PublicationStatus (required): Publication status of an artifact being referred to.
publicationDate	Σ	0..1	date	Date of publication of the artifact being referred to
relatedArtifact:citeAs		0..1	RelatedArtifact	Link or citation to artifact associated with the summary
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
type	Σ	1..1	code	documentation | justification | citation | predecessor | successor | derived-from | depends-on | composed-of | part-of | amends | amended-with | appends | appended-with | cites | cited-by | comments-on | comment-in | contains | contained-in | corrects | correction-in | replaces | replaced-with | retracts | retracted-by | signs | similar-to | supports | supported-with | transforms | transformed-into | transformed-with | documents | specification-of | created-with | cite-as Binding: RelatedArtifactType (required): The type of relationship to the related artifact. Required Pattern: cite-as
classifier	Σ	0..*	CodeableConcept	Additional classifiers Binding: CitationArtifactClassifier (example): Additional classifiers for the related artifact.
label	Σ	0..1	string	Short label
display	Σ	0..1	string	Brief description of the related artifact
citation	Σ	0..1	markdown	Bibliographic citation for the artifact
document	Σ	0..1	Attachment	What document is being referenced
resource	Σ	0..1	canonical(Resource)	What artifact is being referenced
resourceReference	Σ	0..1	Reference(Resource)	What artifact, if not a conformance resource
publicationStatus	Σ	0..1	code	draft | active | retired | unknown Binding: PublicationStatus (required): Publication status of an artifact being referred to.
publicationDate	Σ	0..1	date	Date of publication of the artifact being referred to
description		0..1	markdown	Description of the particular summary
assertion		0..1	markdown	Declarative description of the Evidence
note		0..*	Annotation	Footnotes and/or explanatory notes
Slices for variableDefinition		4..*	BackboneElement	Evidence variable such as population, exposure, or outcome Slice: Unordered, Open by value:note.text
variableDefinition:All Slices				Content/Rules for all slices
id		0..1	string	Unique id for inter-element referencing
Slices for extension		1..*	Extension	Extension Slice: Unordered, Open by value:url
variableRoleCode		1..1	code	population | exposure | outcome | covariate URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code
roleSubtype		0..1	CodeableConcept	subgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-role-subtype Binding: EvidenceVariableRoleSubtype Value Set (extensible)
comparatorCategory		0..1	string	The reference value used for comparison URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-comparator-category
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	A text description or summary of the variable
note		0..*	Annotation	Footnotes and/or explanatory notes
variableRole	Σ	1..1	CodeableConcept	population | subpopulation | exposure | referenceExposure | measuredVariable | confounder Binding: EvidenceVariableRole (extensible): The role that the assertion variable plays.
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	Σ	0..*	Coding	Code defined by a terminology system
text	Σ	0..1	string	Plain text representation of the concept Required Pattern: Use extension:variableRoleCode instead.
observed	Σ	0..1	Reference(Group | EvidenceVariable)	Definition of the actual variable related to the statistic(s)
intended		0..1	Reference(Group | EvidenceVariable)	Definition of the intended variable related to the Evidence
directnessMatch		0..1	CodeableConcept	low | moderate | high | exact Binding: EvidenceDirectness (extensible): The quality of how direct the match is.
variableDefinition:population		1..*	BackboneElement	Evidence variable such as population, exposure, or outcome
id		0..1	string	Unique id for inter-element referencing
Slices for extension		1..*	Extension	Extension Slice: Unordered, Open by value:url
variableRoleCode		1..1	(Complex)	population | exposure | outcome | covariate URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code
id		0..1	id	Unique id for inter-element referencing
extension		0..0
url		1..1	uri	"http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code"
value[x]		0..1	code	Value of extension Required Pattern: population
roleSubtype		0..1	CodeableConcept	subgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-role-subtype Binding: EvidenceVariableRoleSubtype Value Set (extensible)
comparatorCategory		0..1	string	The reference value used for comparison URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-comparator-category
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	A text description or summary of the variable
note		0..*	Annotation	Footnotes and/or explanatory notes
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
author[x]	Σ	0..1		Individual responsible for the annotation
authorReference			Reference(Practitioner | PractitionerRole | Patient | RelatedPerson | Organization)
authorString			string
time	Σ	0..1	dateTime	When the annotation was made
text	Σ	1..1	markdown	The annotation - text content (as markdown) Required Pattern: population
variableRole	Σ	1..1	CodeableConcept	population | subpopulation | exposure | referenceExposure | measuredVariable | confounder Binding: EvidenceVariableRole (extensible): The role that the assertion variable plays.
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	Σ	0..*	Coding	Code defined by a terminology system
text	Σ	0..1	string	Plain text representation of the concept Required Pattern: Use extension:variableRoleCode instead.
observed	Σ	0..1	Reference(StudyGroup | ExposureGroup | ComparatorGroup | MetaanalysisStudyGroup)	Definition of the actual variable related to the statistic(s)
intended		0..1	Reference(Group)	Definition of the intended variable related to the Evidence
directnessMatch		0..1	CodeableConcept	low | moderate | high | exact Binding: EvidenceDirectness (extensible): The quality of how direct the match is.
variableDefinition:exposure		1..1	BackboneElement	Evidence variable such as population, exposure, or outcome
id		0..1	string	Unique id for inter-element referencing
Slices for extension		2..*	Extension	Extension Slice: Unordered, Open by value:url
variableRoleCode		1..1	(Complex)	population | exposure | outcome | covariate URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code
id		0..1	id	Unique id for inter-element referencing
extension		0..0
url		1..1	uri	"http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code"
value[x]		0..1	code	Value of extension Required Pattern: exposure
roleSubtype		0..1	CodeableConcept	subgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-role-subtype Binding: EvidenceVariableRoleSubtype Value Set (extensible)
comparatorCategory		1..1	string	The reference value used for comparison URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-comparator-category
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	A text description or summary of the variable
note		0..*	Annotation	Footnotes and/or explanatory notes
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
author[x]	Σ	0..1		Individual responsible for the annotation
authorReference			Reference(Practitioner | PractitionerRole | Patient | RelatedPerson | Organization)
authorString			string
time	Σ	0..1	dateTime	When the annotation was made
text	Σ	1..1	markdown	The annotation - text content (as markdown) Required Pattern: exposure
variableRole	Σ	1..1	CodeableConcept	population | subpopulation | exposure | referenceExposure | measuredVariable | confounder Binding: EvidenceVariableRole (extensible): The role that the assertion variable plays.
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	Σ	0..*	Coding	Code defined by a terminology system
text	Σ	0..1	string	Plain text representation of the concept Required Pattern: Use extension:variableRoleCode instead.
observed	Σ	0..1	Reference(GroupAssignment)	Definition of the actual variable related to the statistic(s)
intended		0..1	Reference(VariableDefinition)	Definition of the intended variable related to the Evidence
directnessMatch		0..1	CodeableConcept	low | moderate | high | exact Binding: EvidenceDirectness (extensible): The quality of how direct the match is.
variableDefinition:outcome	S	1..*	BackboneElement	Evidence variable such as population, exposure, or outcome
id		0..1	string	Unique id for inter-element referencing
Slices for extension		1..*	Extension	Extension Slice: Unordered, Open by value:url
variableRoleCode		1..1	(Complex)	population | exposure | outcome | covariate URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code
id		0..1	id	Unique id for inter-element referencing
extension		0..0
url		1..1	uri	"http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code"
value[x]		0..1	code	Value of extension Required Pattern: outcome
roleSubtype		0..1	CodeableConcept	subgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-role-subtype Binding: EvidenceVariableRoleSubtype Value Set (extensible)
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	A text description or summary of the variable
note		0..*	Annotation	Footnotes and/or explanatory notes
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
author[x]	Σ	0..1		Individual responsible for the annotation
authorReference			Reference(Practitioner | PractitionerRole | Patient | RelatedPerson | Organization)
authorString			string
time	Σ	0..1	dateTime	When the annotation was made
text	Σ	1..1	markdown	The annotation - text content (as markdown) Required Pattern: outcome
variableRole	Σ	1..1	CodeableConcept	population | subpopulation | exposure | referenceExposure | measuredVariable | confounder Binding: EvidenceVariableRole (extensible): The role that the assertion variable plays.
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	Σ	0..*	Coding	Code defined by a terminology system
text	Σ	0..1	string	Plain text representation of the concept Required Pattern: Use extension:variableRoleCode instead.
observed	Σ	0..1	Reference(VariableDefinition)	Definition of the actual variable related to the statistic(s)
intended		0..1	Reference(EvidenceVariable)	Definition of the intended variable related to the Evidence
directnessMatch		0..1	CodeableConcept	low | moderate | high | exact Binding: EvidenceDirectness (extensible): The quality of how direct the match is.
variableDefinition:covariate		1..*	BackboneElement	Evidence variable such as population, exposure, or outcome
id		0..1	string	Unique id for inter-element referencing
Slices for extension		1..*	Extension	Extension Slice: Unordered, Open by value:url
variableRoleCode		1..1	(Complex)	population | exposure | outcome | covariate URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code
id		0..1	id	Unique id for inter-element referencing
extension		0..0
url		1..1	uri	"http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code"
value[x]		0..1	code	Value of extension Required Pattern: covariate
roleSubtype		0..1	(Complex)	subgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-role-subtype
id		0..1	id	Unique id for inter-element referencing
extension		0..0
url		1..1	uri	"http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-role-subtype"
value[x]		0..1	CodeableConcept	Value of extension Binding: EvidenceVariableRoleSubtype Value Set (extensible)
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	Σ	0..*	Coding	Code defined by a terminology system
text	Σ	0..1	string	Plain text representation of the concept Required Pattern: Relative Value Multiplier
comparatorCategory		0..1	string	The reference value used for comparison URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-comparator-category
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	A text description or summary of the variable
note		0..*	Annotation	Footnotes and/or explanatory notes
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
author[x]	Σ	0..1		Individual responsible for the annotation
authorReference			Reference(Practitioner | PractitionerRole | Patient | RelatedPerson | Organization)
authorString			string
time	Σ	0..1	dateTime	When the annotation was made
text	Σ	1..1	markdown	The annotation - text content (as markdown) Required Pattern: covariate
variableRole	Σ	1..1	CodeableConcept	population | subpopulation | exposure | referenceExposure | measuredVariable | confounder Binding: EvidenceVariableRole (extensible): The role that the assertion variable plays.
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	Σ	0..*	Coding	Code defined by a terminology system
text	Σ	0..1	string	Plain text representation of the concept Required Pattern: Use extension:variableRoleCode instead.
observed	Σ	0..1	Reference(Group | EvidenceVariable)	Definition of the actual variable related to the statistic(s)
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
reference	ΣC	0..1	string	Literal reference, Relative, internal or absolute URL
type	Σ	0..1	uri	Type the reference refers to (e.g. "Patient") - must be a resource in resources Binding: ResourceType (extensible): Aa resource (or, for logical models, the URI of the logical model).
identifier	ΣC	0..1	Identifier	Logical reference, when literal reference is not known
display	ΣC	0..1	string	Text alternative for the resource Required Pattern: Relative Importance Multiplier
directnessMatch		0..1	CodeableConcept	low | moderate | high | exact Binding: EvidenceDirectness (extensible): The quality of how direct the match is.
synthesisType		0..1	CodeableConcept	The method to combine studies Binding: StatisticSynthesisType (extensible): Types of combining results from a body of evidence (e.g. summary data meta-analysis).
studyDesign		0..*	CodeableConcept	The design of the study that produced this evidence Binding: StudyDesign (extensible): This is a set of terms for study design characteristics.
Slices for statistic		1..*	BackboneElement	Values and parameters for a single statistic Slice: Unordered, Open by value:statisticType.coding
statistic:All Slices				Content/Rules for all slices
id		0..1	string	Unique id for inter-element referencing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
modelExpression		0..1	Expression	The formula for analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-expression
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	Description of content
note		0..*	Annotation	Footnotes and/or explanatory notes
statisticType		0..1	CodeableConcept	Type of statistic, e.g., relative risk Binding: StatisticType (extensible)
category		0..1	CodeableConcept	Associated category for categorical variable
quantity		0..1	Quantity	Statistic value
numberOfEvents		0..1	unsignedInt	The number of events associated with the statistic
numberAffected		0..1	unsignedInt	The number of participants affected
sampleSize		0..1	BackboneElement	Number of samples in the statistic
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	Textual description of sample size for statistic
note		0..*	Annotation	Footnote or explanatory note about the sample size
numberOfStudies		0..1	unsignedInt	Number of contributing studies
numberOfParticipants		0..1	unsignedInt	Cumulative number of participants
knownDataCount		0..1	unsignedInt	Number of participants with known results for measured variables
attributeEstimate		0..*	BackboneElement	An attribute of the Statistic
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	Textual description of the attribute estimate
note		0..*	Annotation	Footnote or explanatory note about the estimate
type		0..1	CodeableConcept	The type of attribute estimate, e.g., confidence interval or p value Binding: AttributeEstimateType (extensible)
quantity		0..1	Quantity	The singular quantity of the attribute estimate, for attribute estimates represented as single values; also used to report unit of measure
level		0..1	decimal	Level of confidence interval, e.g., 0.95 for 95% confidence interval
range		0..1	Range	Lower and upper bound values of the attribute estimate
attributeEstimate		0..*	See attributeEstimate (Evidence)	A nested attribute estimate; which is the attribute estimate of an attribute estimate
modelCharacteristic		0..*	BackboneElement	An aspect of the statistical model
id		0..1	string	Unique id for inter-element referencing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
valueQuantity		0..1	SimpleQuantity	Value as Quantity URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-quantity
valueRange		0..1	Range	Value as Range URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-range
valueCodeableConcept		0..1	CodeableConcept	Value as CodeableConcept URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-codeableconcept
intended		0..1	boolean	The plan for analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-intended
applied		0..1	boolean	The analysis that was applied URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-applied
includeIf		0..1	(Complex)	Condition upon which to include the variable or model characteristic in the analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-include-if
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
code		1..1	CodeableConcept	Model specification Binding: StatisticModelCode (extensible)
variable		0..*	BackboneElement	A variable adjusted for in the adjusted analysis
id		0..1	string	Unique id for inter-element referencing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
includeIf		0..1	(Complex)	Condition upon which to include the variable or model characteristic in the analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-include-if
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
variableDefinition		1..1	Reference(Group | EvidenceVariable)	Description of the variable
handling		0..1	code	continuous | dichotomous | ordinal | polychotomous Binding: EvidenceVariableHandling (required)
valueCategory		0..*	CodeableConcept	Description for grouping of ordinal or polychotomous variables
valueQuantity		0..*	Quantity	Discrete value for grouping of ordinal or polychotomous variables
valueRange		0..*	Range	Range of values for grouping of ordinal or polychotomous variables
attributeEstimate		0..*	See attributeEstimate (Evidence)	An attribute of the statistic used as a model characteristic
statistic:netEffect	S	1..1	BackboneElement	Values and parameters for a single statistic
id		0..1	string	Unique id for inter-element referencing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
modelExpression		0..1	Expression	The formula for analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-expression
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	Description of content
note		0..*	Annotation	Footnotes and/or explanatory notes
statisticType		0..1	CodeableConcept	Type of statistic, e.g., relative risk Binding: StatisticType (extensible)
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	Σ	1..1	Coding	Code defined by a terminology system Required Pattern: At least the following
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
system		1..1	uri	Identity of the terminology system Fixed Value: https://fevir.net/resources/CodeSystem/181513
version		0..1	string	Version of the system - if relevant
code		1..1	code	Symbol in syntax defined by the system Fixed Value: STATO:0000424
display		1..1	string	Representation defined by the system Fixed Value: Risk Difference
userSelected		0..1	boolean	If this coding was chosen directly by the user
text	Σ	0..1	string	Plain text representation of the concept
category		0..1	CodeableConcept	Associated category for categorical variable
quantity		0..1	Quantity	Statistic value
numberOfEvents		0..1	unsignedInt	The number of events associated with the statistic
numberAffected		0..1	unsignedInt	The number of participants affected
sampleSize		0..1	BackboneElement	Number of samples in the statistic
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	Textual description of sample size for statistic
note		0..*	Annotation	Footnote or explanatory note about the sample size
numberOfStudies		0..1	unsignedInt	Number of contributing studies
numberOfParticipants		0..1	unsignedInt	Cumulative number of participants
knownDataCount		0..1	unsignedInt	Number of participants with known results for measured variables
Slices for attributeEstimate		1..*	BackboneElement	An attribute of the Statistic Slice: Unordered, Open by value:type.coding
attributeEstimate:All Slices				Content/Rules for all slices
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	Textual description of the attribute estimate
note		0..*	Annotation	Footnote or explanatory note about the estimate
type		0..1	CodeableConcept	The type of attribute estimate, e.g., confidence interval or p value Binding: AttributeEstimateType (extensible)
quantity		0..1	Quantity	The singular quantity of the attribute estimate, for attribute estimates represented as single values; also used to report unit of measure
level		0..1	decimal	Level of confidence interval, e.g., 0.95 for 95% confidence interval
range		0..1	Range	Lower and upper bound values of the attribute estimate
attributeEstimate		0..*	See attributeEstimate (Evidence)	A nested attribute estimate; which is the attribute estimate of an attribute estimate
attributeEstimate:confidenceInterval	S	1..1	BackboneElement	An attribute of the Statistic
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	Textual description of the attribute estimate
note		0..*	Annotation	Footnote or explanatory note about the estimate
type		0..1	CodeableConcept	The type of attribute estimate, e.g., confidence interval or p value Binding: AttributeEstimateType (extensible)
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	Σ	1..1	Coding	Code defined by a terminology system Required Pattern: At least the following
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
system		1..1	uri	Identity of the terminology system Fixed Value: https://fevir.net/resources/CodeSystem/181513
version		0..1	string	Version of the system - if relevant
code		1..1	code	Symbol in syntax defined by the system Fixed Value: STATO:0000196
display		1..1	string	Representation defined by the system Fixed Value: confidence interval
userSelected		0..1	boolean	If this coding was chosen directly by the user
text	Σ	0..1	string	Plain text representation of the concept
quantity		0..1	Quantity	The singular quantity of the attribute estimate, for attribute estimates represented as single values; also used to report unit of measure
level		0..1	decimal	Level of confidence interval, e.g., 0.95 for 95% confidence interval
range		0..1	Range	Lower and upper bound values of the attribute estimate
attributeEstimate		0..*	See attributeEstimate (Evidence)	A nested attribute estimate; which is the attribute estimate of an attribute estimate
Slices for modelCharacteristic		1..*	BackboneElement	An aspect of the statistical model Slice: Unordered, Open by value:code.coding
modelCharacteristic:All Slices				Content/Rules for all slices
id		0..1	string	Unique id for inter-element referencing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
valueQuantity		0..1	SimpleQuantity	Value as Quantity URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-quantity
valueRange		0..1	Range	Value as Range URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-range
valueCodeableConcept		0..1	CodeableConcept	Value as CodeableConcept URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-codeableconcept
intended		0..1	boolean	The plan for analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-intended
applied		0..1	boolean	The analysis that was applied URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-applied
includeIf		0..1	(Complex)	Condition upon which to include the variable or model characteristic in the analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-include-if
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
code		1..1	CodeableConcept	Model specification Binding: StatisticModelCode (extensible)
variable		0..*	BackboneElement	A variable adjusted for in the adjusted analysis
id		0..1	string	Unique id for inter-element referencing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
includeIf		0..1	(Complex)	Condition upon which to include the variable or model characteristic in the analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-include-if
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
variableDefinition		1..1	Reference(Group | EvidenceVariable)	Description of the variable
handling		0..1	code	continuous | dichotomous | ordinal | polychotomous Binding: EvidenceVariableHandling (required)
valueCategory		0..*	CodeableConcept	Description for grouping of ordinal or polychotomous variables
valueQuantity		0..*	Quantity	Discrete value for grouping of ordinal or polychotomous variables
valueRange		0..*	Range	Range of values for grouping of ordinal or polychotomous variables
attributeEstimate		0..*	See attributeEstimate (Evidence)	An attribute of the statistic used as a model characteristic
modelCharacteristic:netEffectContributionAnalysis	S	1..1	BackboneElement	An aspect of the statistical model
id		0..1	string	Unique id for inter-element referencing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
valueQuantity		0..1	SimpleQuantity	Value as Quantity URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-quantity
valueRange		0..1	Range	Value as Range URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-range
valueCodeableConcept		0..1	CodeableConcept	Value as CodeableConcept URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-codeableconcept
intended		0..1	boolean	The plan for analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-intended
applied		0..1	boolean	The analysis that was applied URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-applied
includeIf		0..1	(Complex)	Condition upon which to include the variable or model characteristic in the analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-include-if
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
code		1..1	CodeableConcept	Model specification Binding: StatisticModelCode (extensible)
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	Σ	1..1	Coding	Code defined by a terminology system Required Pattern: At least the following
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
system		1..1	uri	Identity of the terminology system Fixed Value: https://fevir.net/resources/CodeSystem/181513
version		0..1	string	Version of the system - if relevant
code		1..1	code	Symbol in syntax defined by the system Fixed Value: TBD:net-effect-contribution-analysis
display		1..1	string	Representation defined by the system Fixed Value: Net effect contribution analysis
userSelected		0..1	boolean	If this coding was chosen directly by the user
text	Σ	0..1	string	Plain text representation of the concept
variable		0..*	BackboneElement	A variable adjusted for in the adjusted analysis
id		0..1	string	Unique id for inter-element referencing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
includeIf		0..1	(Complex)	Condition upon which to include the variable or model characteristic in the analysis URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-include-if
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
variableDefinition		1..1	Reference(Group | EvidenceVariable)	Description of the variable
handling		0..1	code	continuous | dichotomous | ordinal | polychotomous Binding: EvidenceVariableHandling (required)
valueCategory		0..*	CodeableConcept	Description for grouping of ordinal or polychotomous variables
valueQuantity		0..*	Quantity	Discrete value for grouping of ordinal or polychotomous variables
valueRange		0..*	Range	Range of values for grouping of ordinal or polychotomous variables
attributeEstimate		0..*	See attributeEstimate (Evidence)	An attribute of the statistic used as a model characteristic
certainty		0..*	BackboneElement	Certainty or quality of the evidence
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description		0..1	markdown	Textual description of certainty
note		0..*	Annotation	Footnotes and/or explanatory notes
type		0..1	CodeableConcept	Aspect of certainty being rated Binding: EvidenceCertaintyType (extensible): The aspect of quality, confidence, or certainty.
rating		0..1	CodeableConcept	Assessment or judgement of the aspect Binding: EvidenceCertaintyRating (extensible): The assessment of quality, confidence, or certainty.
rater		0..1	string	Individual or group who did the rating
subcomponent		0..*	See certainty (Evidence)	A domain or subdomain of certainty
Documentation for this format

Terminology Bindings

Path	Conformance	ValueSet / Code	URI
Evidence.language	required	AllLanguages http://hl7.org/fhir/ValueSet/all-languages|5.0.0 from the FHIR Standard
Evidence.versionAlgorithm[x]	extensible	VersionAlgorithm http://hl7.org/fhir/ValueSet/version-algorithm from the FHIR Standard
Evidence.status	required	PublicationStatus http://hl7.org/fhir/ValueSet/publication-status|5.0.0 from the FHIR Standard
Evidence.relatedArtifact:amendedWith.type	required	Pattern: amended-with http://hl7.org/fhir/ValueSet/related-artifact-type|5.0.0 from the FHIR Standard
Evidence.relatedArtifact:amendedWith.classifier	example	CitationArtifactClassifier http://hl7.org/fhir/ValueSet/citation-artifact-classifier from the FHIR Standard
Evidence.relatedArtifact:amendedWith.publicationStatus	required	PublicationStatus http://hl7.org/fhir/ValueSet/publication-status|5.0.0 from the FHIR Standard
Evidence.relatedArtifact:citeAs.type	required	Pattern: cite-as http://hl7.org/fhir/ValueSet/related-artifact-type|5.0.0 from the FHIR Standard
Evidence.relatedArtifact:citeAs.classifier	example	CitationArtifactClassifier http://hl7.org/fhir/ValueSet/citation-artifact-classifier from the FHIR Standard
Evidence.relatedArtifact:citeAs.publicationStatus	required	PublicationStatus http://hl7.org/fhir/ValueSet/publication-status|5.0.0 from the FHIR Standard
Evidence.variableDefinition.variableRole	extensible	EvidenceVariableRole http://hl7.org/fhir/ValueSet/variable-role from the FHIR Standard
Evidence.variableDefinition.directnessMatch	extensible	EvidenceDirectness http://terminology.hl7.org/ValueSet/directness
Evidence.variableDefinition:population.variableRole	extensible	EvidenceVariableRole http://hl7.org/fhir/ValueSet/variable-role from the FHIR Standard
Evidence.variableDefinition:population.directnessMatch	extensible	EvidenceDirectness http://terminology.hl7.org/ValueSet/directness
Evidence.variableDefinition:exposure.variableRole	extensible	EvidenceVariableRole http://hl7.org/fhir/ValueSet/variable-role from the FHIR Standard
Evidence.variableDefinition:exposure.directnessMatch	extensible	EvidenceDirectness http://terminology.hl7.org/ValueSet/directness
Evidence.variableDefinition:outcome.variableRole	extensible	EvidenceVariableRole http://hl7.org/fhir/ValueSet/variable-role from the FHIR Standard
Evidence.variableDefinition:outcome.directnessMatch	extensible	EvidenceDirectness http://terminology.hl7.org/ValueSet/directness
Evidence.variableDefinition:covariate.extension:roleSubtype.value[x]	extensible	Evidence_variable_role_subtype https://fevir.net/resources/ValueSet/179424 from this IG
Evidence.variableDefinition:covariate.variableRole	extensible	EvidenceVariableRole http://hl7.org/fhir/ValueSet/variable-role from the FHIR Standard
Evidence.variableDefinition:covariate.observed.type	extensible	ResourceType http://hl7.org/fhir/ValueSet/resource-types from the FHIR Standard
Evidence.variableDefinition:covariate.directnessMatch	extensible	EvidenceDirectness http://terminology.hl7.org/ValueSet/directness
Evidence.synthesisType	extensible	StatisticSynthesisType http://terminology.hl7.org/ValueSet/synthesis-type
Evidence.studyDesign	extensible	StudyDesign http://hl7.org/fhir/ValueSet/study-design from the FHIR Standard
Evidence.statistic.statisticType	extensible	StatisticType http://hl7.org/fhir/ValueSet/statistic-type from the FHIR Standard
Evidence.statistic.attributeEstimate.type	extensible	AttributeEstimateType http://hl7.org/fhir/ValueSet/attribute-estimate-type from the FHIR Standard
Evidence.statistic.modelCharacteristic.code	extensible	StatisticModelCode http://hl7.org/fhir/ValueSet/statistic-model-code from the FHIR Standard
Evidence.statistic.modelCharacteristic.variable.handling	required	EvidenceVariableHandling http://hl7.org/fhir/ValueSet/variable-handling|5.0.0 from the FHIR Standard
Evidence.statistic:netEffect.statisticType	extensible	StatisticType http://hl7.org/fhir/ValueSet/statistic-type from the FHIR Standard
Evidence.statistic:netEffect.attributeEstimate.type	extensible	AttributeEstimateType http://hl7.org/fhir/ValueSet/attribute-estimate-type from the FHIR Standard
Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.type	extensible	AttributeEstimateType http://hl7.org/fhir/ValueSet/attribute-estimate-type from the FHIR Standard
Evidence.statistic:netEffect.modelCharacteristic.code	extensible	StatisticModelCode http://hl7.org/fhir/ValueSet/statistic-model-code from the FHIR Standard
Evidence.statistic:netEffect.modelCharacteristic.variable.handling	required	EvidenceVariableHandling http://hl7.org/fhir/ValueSet/variable-handling|5.0.0 from the FHIR Standard
Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.code	extensible	StatisticModelCode http://hl7.org/fhir/ValueSet/statistic-model-code from the FHIR Standard
Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.variable.handling	required	EvidenceVariableHandling http://hl7.org/fhir/ValueSet/variable-handling|5.0.0 from the FHIR Standard
Evidence.certainty.type	extensible	EvidenceCertaintyType http://hl7.org/fhir/ValueSet/certainty-type from the FHIR Standard
Evidence.certainty.rating	extensible	EvidenceCertaintyRating http://hl7.org/fhir/ValueSet/certainty-rating from the FHIR Standard

Constraints

Id	Grade	Path(s)	Details	Requirements
cnl-0	warning	Evidence	Name should be usable as an identifier for the module by machine processing applications such as code generation : name.exists() implies name.matches('^[A-Z]([A-Za-z0-9_]){1,254}$')
cnl-1	warning	Evidence.url	URL should not contain | or # - these characters make processing canonical references problematic : exists() implies matches('^[^|# ]+$')
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children : hasValue() or (children().count() > id.count())
ext-1	error	**ALL** extensions	Must have either extensions or value[x], not both : extension.exists() != value.exists()

This structure is derived from ComparativeEvidence

Summary

Mandatory: 10 elements(2 nested mandatory elements)
Must-Support: 4 elements
Prohibited: 1 element

Structures

This structure refers to these other structures:

• OutcomeImportance (http://hl7.org/fhir/uv/ebm/StructureDefinition/outcome-importance)

Slices

This structure defines the following Slices:

• The element 1 is sliced based on the value of Evidence.relatedArtifact
• The element 1 is sliced based on the value of Evidence.statistic
• The element 1 is sliced based on the value of Evidence.statistic.attributeEstimate
• The element 1 is sliced based on the value of Evidence.statistic.modelCharacteristic

Maturity: 1