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PROTECT-CHILD Pediatric Transplant Data Implementation Guide
0.1.0-ci-build -

PROTECT-CHILD Pediatric Transplant Data Implementation Guide
0.1.0-ci-build - ci-build

PROTECT-CHILD Pediatric Transplant Data Implementation Guide, published by Protect Child. This guide is not an authorized publication; it is the continuous build for version 0.1.0-ci-build built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/hl7-eu/protect-child/ and changes regularly. See the Directory of published versions

Example Bundle: Worked Example — recipient REC-1-0001 full transplant journey

Bundle ProtectChildRecipientJourneyExample of type collection


Entry 1 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Organization/PCCenter1LaPaz

Resource Organization:

Profile: Study Centre

identifier: ProtectChildStudyCentreId/1

name: La Paz University Hospital

Contacts

-Address
*ES

Entry 2 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Patient/ExamplePatientTransplant1

Resource Patient:

Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)


Links:

Entry 3 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Patient/ExampleDonor1

Resource Patient:

Anonymous Patient Male, DoB: 1998-08-01 ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#DON-1-0001)


Deceased:true

Entry 4 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Medication/ImmunosuppressantExample1

Resource Medication:

identifier: ProtectChildId/IMM-0001

code: Steroid (methylprednisolone)

status: Active


Entry 5 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Medication/ImmunosuppressantTacrolimus1

Resource Medication:

identifier: ProtectChildId/IMM-0002

code: CNI (FK506)

status: Active


Entry 6 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/ObservationDefinition/LabTestExample1

Resource ObservationDefinition:

Profile: Lab Test

identifier: ProtectChildId/LBT-0001

code: Albumin [Mass/volume] in Serum or Plasma


Entry 7 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/ObservationDefinition/InstrumentalInvestigationExample1

Resource ObservationDefinition:

identifier: ProtectChildId/INS-0001

code: Liver doppler ultrasound


Entry 8 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Condition/ExamplePatientLiverDiagnosis1

Resource Condition:

clinicalStatus: Active

code: Other and unspecified cirrhosis of liver

bodySite: Liver structure

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

onset: 2020-03-01

note:

Extra details about the diagnosis (free text).


Entry 9 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Encounter/VisitPreTxExample1

Resource Encounter:

Profile: Visit

identifier: ProtectChildId/VIS-1-0001

status: completed

class: inpatient encounter

type: Pre-transplant visit

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)


Entry 10 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/MedicationStatement/PreMedicationExample1

Resource MedicationStatement:

status: not-taken

identifier: ProtectChildId/PRM-1-0001

status: recorded

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

effective: 2023-08-14

note:

No antihypertensive required before transplantation; blood pressure was low-normal throughout the pre-transplant work-up.


Entry 11 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/MedicationStatement/PreMedicationChildExample1

Resource MedicationStatement:

status: completed

status: recorded

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

effective: 2023-07-25


Entry 12 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Observation/ExamplePatientImmunologyObservation1

Resource Observation:

status: Final

category: Laboratory

code: Patient pre-transplant immunology panel (PRA, histological date)

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

encounter: Encounter: identifier = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#VIS-1-0001; status = finished; class = inpatient encounter (ActCode#IMP); type = Pre-transplant visit; period = 2023-07-25 --> 2023-08-28

effective: 2023-08-01

performer: Organization La Paz University Hospital

component

code: Maximum PRA (historical)

value: 80

component

code: Most recent PRA

value: 55

component

code: Earliest date of diagnosis

value: 2020-03-15


Entry 13 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Observation/ImmunologicalDataExample1

Resource Observation:

identifier: ProtectChildId/IMD-1-0001

status: Final

category: Laboratory

code: Immunological data panel

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

encounter: Encounter: identifier = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#VIS-1-0001; status = finished; class = inpatient encounter (ActCode#IMP); type = Pre-transplant visit; period = 2023-07-25 --> 2023-08-28

effective: 2023-08-01

performer: Organization La Paz University Hospital

component

code: ABO group [Type] in Blood

value: Group A

component

code: Rh [Type] in Blood

value: Rh positive

component

code: HLA-A allele 1

value: A*02:01

component

code: HLA-A allele 2

value: A*24:02

component

code: HLA-B allele 1

value: B*07:02

component

code: HLA-B allele 2

value: B*44:03

component

code: HLA-C allele 1

value: C*07:02

component

code: HLA-C allele 2

value: C*16:01

component

code: HLA-DRB1 allele 1

value: DRB1*03:01

component

code: HLA-DRB1 allele 2

value: DRB1*15:01

component

code: HLA-DP allele 1

value: DPB1*04:01

component

code: HLA-DP allele 2

value: DPB1*02:01

component

code: HLA-DQB1 allele 1

value: DQB1*02:01

component

code: HLA-DQB1 allele 2

value: DQB1*06:02

component

code: Pre-transplant anti-HLA DSA

value: No donor-specific antibodies detected on pre-transplant screen

component

code: Presence of anti-HLA antibodies

value: false


Entry 14 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Observation/ExampleDonorAgeObservation1

Resource Observation:

status: Final

category: Survey

code: Patient demographics panel (age)

subject: Anonymous Patient Male, DoB: 1998-08-01 ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#DON-1-0001)

effective: 2023-08-15

performer: Organization La Paz University Hospital

component

code: Age

value: 25 years (Details: UCUM codea = 'a')

component

code: Patient age in months

value: 300 months (Details: UCUM codemo = 'mo')


Entry 15 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Observation/ExampleDonorLiverType1

Resource Observation:

Transplant type context: Liver transplant

status: Final

category: Procedure

code: Transplant type [Anatomy]

subject: Anonymous Patient Male, DoB: 1998-08-01 ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#DON-1-0001)

effective: 2023-08-15

performer: Organization La Paz University Hospital

value: Split liver graft


Entry 16 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Observation/ExamplePatientAgeObservation1

Resource Observation:

status: Final

category: Survey

code: Patient demographics panel (age)

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

effective: 2023-08-15

performer: Organization La Paz University Hospital

component

code: Age

value: 9 years (Details: UCUM codea = 'a')

component

code: Patient age in months

value: 108 months (Details: UCUM codemo = 'mo')


Entry 17 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Procedure/TransplantExample1

Resource Procedure:

Profile: Transplant

Transplant donor reference: Anonymous Patient Male, DoB: 1998-08-01 ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#DON-1-0001)

identifier: ProtectChildId/TXP-1-0001

status: Completed

code: Liver transplant

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

encounter: Encounter: identifier = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#VIS-1-0001; status = finished; class = inpatient encounter (ActCode#IMP); type = Pre-transplant visit; period = 2023-07-25 --> 2023-08-28

complication: No display for Procedure.complication (reference: ->Condition Major bleeding)


Entry 18 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Procedure/TransplantAnastomosisExample1

Resource Procedure:

partOf: Procedure Liver transplant

status: Completed

code: Duct-to-duct anastomosis

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

encounter: Encounter: identifier = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#VIS-1-0001; status = finished; class = inpatient encounter (ActCode#IMP); type = Pre-transplant visit; period = 2023-07-25 --> 2023-08-28


Entry 19 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Condition/IntraoperativeComplicationExample1

Resource Condition:

category: Encounter Diagnosis

code: Major bleeding

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

encounter: Encounter: identifier = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#VIS-1-0001; status = finished; class = inpatient encounter (ActCode#IMP); type = Pre-transplant visit; period = 2023-07-25 --> 2023-08-28

onset: 2023-08-15


Entry 20 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Observation/TransplantDetailsExample1

Resource Observation:

partOf: Procedure Liver transplant

status: Final

category: Procedure

code: Transplant details panel

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

effective: 2023-08-15

performer: Organization La Paz University Hospital

component

code: Time from diagnosis to transplant (months)

value: 41 months (Details: UCUM codemo = 'mo')

component

code: Donor/recipient weight ratio

value: 2.3 1 (Details: UCUM code1 = '1')

component

code: Cold ischemia time (minutes)

value: 480 min (Details: UCUM codemin = 'min')

component

code: Warm ischemia time (minutes)

value: 45 min (Details: UCUM codemin = 'min')


Entry 21 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/MedicationStatement/ImmPatInductionExample1

Resource MedicationStatement:

status: completed

identifier: ProtectChildId/IMP-1-0001

status: recorded

category: Induction

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

effective: 2023-08-15 --> 2023-08-15

dosage

DoseAndRates

-Dose[x]
*10 mg/kg (Details: UCUM codemg.kg-1 = 'mg.kg-1')

Entry 22 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Condition/ClinicalEventAkiExample1

Resource Condition:

identifier: ProtectChildId/CLE-1-0001

clinicalStatus: Active

code: Episodes of AKI after liver transplant

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

encounter: Encounter: identifier = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#VIS-1-0001; status = finished; class = inpatient encounter (ActCode#IMP); type = Pre-transplant visit; period = 2023-07-25 --> 2023-08-28

onset: 2023-08-20


Entry 23 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Procedure/ClinicalEventDialysisProcedureExample1

Resource Procedure:

status: Completed

code: Hemodialysis

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)


Entry 24 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Encounter/VisitExample1

Resource Encounter:

Profile: Visit

identifier: ProtectChildId/VIS-1-0002

status: completed

class: ambulatory

type: 1 month visit

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)


Entry 25 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Observation/VitalSignExample1

Resource Observation:

Profile: Vital Sign

identifier: ProtectChildId/VIT-1-0001

status: Final

category: Vital Signs

code: Vital signs panel

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

encounter: Encounter: identifier = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#VIS-1-0002; status = finished; class = ambulatory (ActCode#AMB); type = 1 month visit; period = 2023-09-15 --> 2023-09-15

effective: 2023-09-15

performer: Organization La Paz University Hospital

component

code: Systolic blood pressure

value: 118 mmHg (Details: UCUM codemm[Hg] = 'mm[Hg]')

component

code: Diastolic blood pressure

value: 75 mmHg (Details: UCUM codemm[Hg] = 'mm[Hg]')

component

code: Heart rate

value: 72 bpm (Details: UCUM code/min = '/min')

component

code: Body temperature

value: 36.7 °C (Details: UCUM codeCel = 'Cel')

component

code: Body mass index (BMI) [Ratio]

value: 19.8 kg/m² (Details: UCUM codekg/m2 = 'kg/m2')


Entry 26 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Observation/lab-result-observation-example-1

Resource Observation:

Profile: Lab Result

identifier: ProtectChildId/LBR-1-0001

status: Final

category: Laboratory

code: Creatinine [Mass/volume] in Serum or Plasma

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

encounter: Encounter: identifier = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#VIS-1-0002; status = finished; class = ambulatory (ActCode#AMB); type = 1 month visit; period = 2023-09-15 --> 2023-09-15

effective: 2023-09-15 09:15:00+0200

performer: Organization La Paz University Hospital

value: 1.2 mg/dL (Details: UCUM codemg/dL = 'mg/dL')

interpretation: High


Entry 27 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Observation/lab-result-albumin-month-1

Resource Observation:

Profile: Lab Result

identifier: ProtectChildId/LBR-1-0002

status: Final

category: Laboratory

code: Albumin [Mass/volume] in Serum or Plasma

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

encounter: Encounter: identifier = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#VIS-1-0002; status = finished; class = ambulatory (ActCode#AMB); type = 1 month visit; period = 2023-09-15 --> 2023-09-15

effective: 2023-09-15 09:15:00+0200

performer: Organization La Paz University Hospital

value: 3.4 g/dL (Details: UCUM codeg/dL = 'g/dL')

interpretation: Low


Entry 28 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Observation/lab-result-alt-month-1

Resource Observation:

Profile: Lab Result

identifier: ProtectChildId/LBR-1-0003

status: Final

category: Laboratory

code: Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

encounter: Encounter: identifier = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#VIS-1-0002; status = finished; class = ambulatory (ActCode#AMB); type = 1 month visit; period = 2023-09-15 --> 2023-09-15

effective: 2023-09-15 09:15:00+0200

performer: Organization La Paz University Hospital

value: 86 U/L (Details: UCUM code[IU]/L = '[IU]/L')

interpretation: High


Entry 29 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Specimen/biosample-example-1

Resource Specimen:

Visit reference: Encounter: identifier = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#VIS-1-0002; status = finished; class = ambulatory (ActCode#AMB); type = 1 month visit; period = 2023-09-15 --> 2023-09-15

identifier: ProtectChildId/BIO-1-0001

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

receivedTime: 2023-09-20

Collections

-Collected[x]
*2023-09-15

Entry 30 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/ServiceRequest/BioSampleGenomicRequest1

Resource ServiceRequest:

status: Active

intent: Order

code: No display for ServiceRequest.code (concept: Genomic analysis)

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

encounter: Encounter: identifier = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#VIS-1-0002; status = finished; class = ambulatory (ActCode#AMB); type = 1 month visit; period = 2023-09-15 --> 2023-09-15

authoredOn: 2023-09-15

specimen: Specimen: extension = ->Encounter: identifier = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#VIS-1-0002; status = finished; class = ambulatory (ActCode#AMB); type = 1 month visit; period = 2023-09-15 --> 2023-09-15; identifier = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#BIO-1-0001; receivedTime = 2023-09-20


Entry 31 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Observation/ClinicalVariableExample1

Resource Observation:

identifier: ProtectChildId/CLV-1-0001

status: Final

category: Exam

code: Clinical information

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

encounter: Encounter: identifier = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#VIS-1-0002; status = finished; class = ambulatory (ActCode#AMB); type = 1 month visit; period = 2023-09-15 --> 2023-09-15

effective: 2023-09-15

performer: Organization La Paz University Hospital

note:

Patient reports intermittent fatigue.

component

code: Body weight

value: 32.5 kg (Details: UCUM codekg = 'kg')

component

code: Body height

value: 128 cm (Details: UCUM codecm = 'cm')

component

code: Urine output 24 hour

value: 1200 ml/day (Details: UCUM codemL/d = 'mL/d')


Entry 32 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Condition/ConcomitantDiseaseExample1

Resource Condition:

category: Problem List Item

code: Hypertension

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

encounter: Encounter: identifier = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#VIS-1-0002; status = finished; class = ambulatory (ActCode#AMB); type = 1 month visit; period = 2023-09-15 --> 2023-09-15

onset: 2023-09-01


Entry 33 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Observation/microbiology-example-1

Resource Observation:

Profile: Microbiology

identifier: ProtectChildId/MIC-1-0001

status: Final

code: Microbiology studies panel

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

encounter: Encounter: identifier = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#VIS-1-0002; status = finished; class = ambulatory (ActCode#AMB); type = 1 month visit; period = 2023-09-15 --> 2023-09-15

effective: 2023-09-15

performer: Organization La Paz University Hospital

component

code: EBV-DNA (quantitative)

value: true

component

code: EBV-DNA copies/ml

value: 2450 {copies}/mL (Details: UCUM code{copies}/mL = '{copies}/mL')

component

code: EBV IgM anti-EA

value: false

component

code: EBV IgM anti-VCA

value: false

component

code: EBV IgG anti-VCA

value: true

component

code: EBV IgG EBNA

value: true

component

code: CMV-DNA

value: false

component

code: CMV IgM

value: false

component

code: CMV IgG

value: true

component

code: Parvovirus B19 DNA

value: false

component

code: Parvovirus B19 IgG

value: true

component

code: Parvovirus B19 IgM

value: false

component

code: HSV IgG

value: true

component

code: HSV IgM

value: false

component

code: Adenovirus IgG

value: true

component

code: Adenovirus IgM

value: false

component

code: VZV IgG

value: true

component

code: VZV IgM

value: false

component

code: Blood BKV-DNA

value: false

component

code: Urine BKV-DNA

value: false


Entry 34 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Condition/MicrobiologyDiagnosisExample1

Resource Condition:

category: Encounter Diagnosis

code: EBV Hepatitis on liver

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

encounter: Encounter: identifier = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#VIS-1-0002; status = finished; class = ambulatory (ActCode#AMB); type = 1 month visit; period = 2023-09-15 --> 2023-09-15

onset: 2023-09-15


Entry 35 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/MedicationStatement/ImmPatMaintenanceExample1

Resource MedicationStatement:

status: active

identifier: ProtectChildId/IMP-1-0002

status: recorded

category: Maintenance

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

effective: 2023-09-15 --> 2023-09-20

dosage

DoseAndRates

-Dose[x]
*0.1 mg/kg (Details: UCUM codemg.kg-1 = 'mg.kg-1')

Entry 36 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Observation/ImmPatPKObservationExample1

Resource Observation:

partOf: MedicationStatement: identifier = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#IMP-1-0002; status = active; category = Maintenance; medication[x] = ->Medication CNI (FK506); effective[x] = 2023-09-15 --> 2023-09-20

status: Final

category: Laboratory

code: Pre-dose drug level (trough / C0)

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

effective: 2023-09-15

performer: Organization La Paz University Hospital

value: 8.5 ng/mL (Details: UCUM codeng.mL-1 = 'ng.mL-1')


Entry 37 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/MedicationStatement/ImmPatEbvReducedExample1

Resource MedicationStatement:

status: active

identifier: ProtectChildId/IMP-1-0003

status: recorded

category: Maintenance

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

effective: 2023-09-20 --> (ongoing)

dosage

text: Reduced from 0.1 mg/kg for EBV viraemia. Divided twice daily.

DoseAndRates

-Dose[x]
*0.06 mg/kg (Details: UCUM codemg.kg-1 = 'mg.kg-1')

Entry 38 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Observation/LiverHistologyEbvExample1

Resource Observation:

identifier: ProtectChildId/IIV-1-0002

status: Final

code: Liver Histology

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

encounter: Encounter: identifier = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#VIS-1-0002; status = finished; class = ambulatory (ActCode#AMB); type = 1 month visit; period = 2023-09-15 --> 2023-09-15

effective: 2023-09-15

performer: Organization La Paz University Hospital

value: Abnormal

Components

-CodeValue[x]
*Abnormality descriptionPortal and lobular mononuclear infiltrate, EBER-positive nuclei; no bile duct damage or endothelialitis — favours EBV hepatitis over rejection.

Entry 39 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Encounter/VisitClinicalEventExample1

Resource Encounter:

Profile: Visit

identifier: ProtectChildId/VIS-1-0003

status: completed

class: ambulatory

type: Clinical Event visit

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)


Entry 40 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Condition/ClinicalEventExample1

Resource Condition:

identifier: ProtectChildId/CLE-1-0002

clinicalStatus: Active

code: Liver Rejection Episode

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

encounter: Encounter: identifier = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#VIS-1-0003; status = finished; class = ambulatory (ActCode#AMB); type = Clinical Event visit; period = 2023-11-15 --> 2023-11-15

onset: 2023-11-15


Entry 41 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Observation/ImmunologicalDataExample2

Resource Observation:

identifier: ProtectChildId/IMD-1-0002

status: Final

category: Laboratory

code: Immunological data panel

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

encounter: Encounter: identifier = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#VIS-1-0003; status = finished; class = ambulatory (ActCode#AMB); type = Clinical Event visit; period = 2023-11-15 --> 2023-11-15

effective: 2023-11-15

performer: Organization La Paz University Hospital

component

code: IHC/IF C4d result

value: true

component

code: C4d result detail

value: C4d positive in the portal microvasculature, diffuse portal capillary staining

component

code: Immunofluorescence result

value: Diffuse portal microvascular C4d staining; no immune-complex deposition

component

code: Post-transplant anti-HLA DSA class

value: Class I

component

code: MFI category

value: SR (strong, >4k)

component

code: Antibody type specification

value: Anti-HLA class I donor-specific antibody against B*44:03

component

code: ANCA result

value: false


Entry 42 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Observation/ClinicalEventFlagObservationExample1

Resource Observation:

status: Final

category: Exam

code: Treatment adherence confirmed

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

focus: Condition Liver Rejection Episode

encounter: Encounter: identifier = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#VIS-1-0003; status = finished; class = ambulatory (ActCode#AMB); type = Clinical Event visit; period = 2023-11-15 --> 2023-11-15

effective: 2023-11-15

performer: Organization La Paz University Hospital

value: true


Entry 43 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Observation/lab-result-alt-rejection-1

Resource Observation:

Profile: Lab Result

identifier: ProtectChildId/LBR-1-0007

status: Final

category: Laboratory

code: Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

encounter: Encounter: identifier = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#VIS-1-0003; status = finished; class = ambulatory (ActCode#AMB); type = Clinical Event visit; period = 2023-11-15 --> 2023-11-15

effective: 2023-11-15 08:30:00+0100

performer: Organization La Paz University Hospital

value: 210 U/L (Details: UCUM code[IU]/L = '[IU]/L')

interpretation: High


Entry 44 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Observation/lab-result-bilirubin-rejection-1

Resource Observation:

Profile: Lab Result

identifier: ProtectChildId/LBR-1-0008

status: Final

category: Laboratory

code: Bilirubin.total [Mass/volume] in Serum or Plasma

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

encounter: Encounter: identifier = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#VIS-1-0003; status = finished; class = ambulatory (ActCode#AMB); type = Clinical Event visit; period = 2023-11-15 --> 2023-11-15

effective: 2023-11-15 08:30:00+0100

performer: Organization La Paz University Hospital

value: 3.8 mg/dL (Details: UCUM codemg/dL = 'mg/dL')

interpretation: High


Entry 45 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Observation/lab-result-ggt-rejection-1

Resource Observation:

Profile: Lab Result

identifier: ProtectChildId/LBR-1-0009

status: Final

category: Laboratory

code: Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

encounter: Encounter: identifier = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#VIS-1-0003; status = finished; class = ambulatory (ActCode#AMB); type = Clinical Event visit; period = 2023-11-15 --> 2023-11-15

effective: 2023-11-15 08:30:00+0100

performer: Organization La Paz University Hospital

value: 180 U/L (Details: UCUM code[IU]/L = '[IU]/L')

interpretation: High


Entry 46 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/MedicationStatement/ImmPatRejectionTreatmentExample1

Resource MedicationStatement:

status: completed

identifier: ProtectChildId/IMP-1-0004

status: recorded

category: Maintenance

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

effective: 2023-11-15 --> 2023-11-17

dosage

text: Rejection treatment, not maintenance: IV methylprednisolone pulse once daily for three days.

DoseAndRates

-Dose[x]
*10 mg/kg (Details: UCUM codemg.kg-1 = 'mg.kg-1')

Entry 47 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Encounter/VisitMonth6Example1

Resource Encounter:

Profile: Visit

identifier: ProtectChildId/VIS-1-0004

status: completed

class: ambulatory

type: 6 month visit

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)


Entry 48 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/MedicationStatement/ConcomitantMedicationExample1

Resource MedicationStatement:

status: active

identifier: ProtectChildId/CMD-1-0001

status: recorded

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

effective: 2023-09-15 --> (ongoing)

dosage

DoseAndRates

-Dose[x]
*5 mg (Details: UCUM codemg = 'mg')

Entry 49 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Observation/PatientInstrumentalInvestigationExample1

Resource Observation:

identifier: ProtectChildId/IIV-1-0001

status: Final

code: Liver doppler ultrasound

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

encounter: Encounter: identifier = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#VIS-1-0004; status = finished; class = ambulatory (ActCode#AMB); type = 6 month visit; period = 2024-02-15 --> 2024-02-15

effective: 2024-02-15

performer: Organization La Paz University Hospital

value: Normal


Entry 50 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Encounter/VisitMonth12Example1

Resource Encounter:

Profile: Visit

identifier: ProtectChildId/VIS-1-0005

status: completed

class: ambulatory

type: 12 month visit

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)


Entry 51 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Observation/VitalSignExample2

Resource Observation:

Profile: Vital Sign

identifier: ProtectChildId/VIT-1-0002

status: Final

category: Vital Signs

code: Vital signs panel

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

encounter: Encounter: identifier = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#VIS-1-0005; status = finished; class = ambulatory (ActCode#AMB); type = 12 month visit; period = 2024-08-15 --> 2024-08-15

effective: 2024-08-15

performer: Organization La Paz University Hospital

component

code: Systolic blood pressure

value: 112 mmHg (Details: UCUM codemm[Hg] = 'mm[Hg]')

component

code: Diastolic blood pressure

value: 70 mmHg (Details: UCUM codemm[Hg] = 'mm[Hg]')

component

code: Heart rate

value: 80 bpm (Details: UCUM code/min = '/min')

component

code: Oxygen saturation in Arterial blood by Pulse oximetry

value: 98 % (Details: UCUM code% = '%')

component

code: Systolic blood pressure percentile

value: 82

component

code: Diastolic blood pressure percentile

value: 74

component

code: Systolic blood pressure 24 hour mean

value: 114 mmHg (Details: UCUM codemm[Hg] = 'mm[Hg]')

component

code: Diastolic blood pressure 24 hour mean

value: 68 mmHg (Details: UCUM codemm[Hg] = 'mm[Hg]')

component

code: Mean systolic blood pressure — daytime (mmHg)

value: 119 mmHg (Details: UCUM codemm[Hg] = 'mm[Hg]')

component

code: Mean diastolic blood pressure — daytime (mmHg)

value: 72 mmHg (Details: UCUM codemm[Hg] = 'mm[Hg]')

component

code: Mean systolic blood pressure — night-time (mmHg)

value: 104 mmHg (Details: UCUM codemm[Hg] = 'mm[Hg]')

component

code: Mean diastolic blood pressure — night-time (mmHg)

value: 60 mmHg (Details: UCUM codemm[Hg] = 'mm[Hg]')

component

code: Systolic blood pressure load (%)

value: 22 % (Details: UCUM code% = '%')

component

code: Diastolic blood pressure load (%)

value: 15 % (Details: UCUM code% = '%')

component

code: Systolic blood pressure nocturnal dip (%)

value: 12.6 % (Details: UCUM code% = '%')

component

code: Diastolic blood pressure nocturnal dip (%)

value: 16.7 % (Details: UCUM code% = '%')


Entry 52 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Observation/lab-result-observation-example-2

Resource Observation:

Profile: Lab Result

identifier: ProtectChildId/LBR-1-0004

status: Final

category: Laboratory

code: Creatinine [Mass/volume] in Serum or Plasma

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

encounter: Encounter: identifier = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#VIS-1-0005; status = finished; class = ambulatory (ActCode#AMB); type = 12 month visit; period = 2024-08-15 --> 2024-08-15

effective: 2024-08-15 09:00:00+0200

performer: Organization La Paz University Hospital

value: 0.8 mg/dL (Details: UCUM codemg/dL = 'mg/dL')

interpretation: High


Entry 53 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Observation/lab-result-albumin-month-12

Resource Observation:

Profile: Lab Result

identifier: ProtectChildId/LBR-1-0005

status: Final

category: Laboratory

code: Albumin [Mass/volume] in Serum or Plasma

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

encounter: Encounter: identifier = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#VIS-1-0005; status = finished; class = ambulatory (ActCode#AMB); type = 12 month visit; period = 2024-08-15 --> 2024-08-15

effective: 2024-08-15 09:00:00+0200

performer: Organization La Paz University Hospital

value: 4.2 g/dL (Details: UCUM codeg/dL = 'g/dL')

interpretation: Normal


Entry 54 - fullUrl = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/Observation/lab-result-alt-month-12

Resource Observation:

Profile: Lab Result

identifier: ProtectChildId/LBR-1-0006

status: Final

category: Laboratory

code: Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

subject: Anonymous Patient Female, DoB Unknown ( https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#REC-1-0001)

encounter: Encounter: identifier = https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/NamingSystem/protect-child-id#ProtectChildId#VIS-1-0005; status = finished; class = ambulatory (ActCode#AMB); type = 12 month visit; period = 2024-08-15 --> 2024-08-15

effective: 2024-08-15 09:00:00+0200

performer: Organization La Paz University Hospital

value: 31 U/L (Details: UCUM code[IU]/L = '[IU]/L')

interpretation: Normal