PROTECT-CHILD Pediatric Transplant Data Implementation Guide, published by Protect Child. This guide is not an authorized publication; it is the continuous build for version 0.1.0-ci-build built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/hl7-eu/protect-child/ and changes regularly. See the Directory of published versions

Mapping

Logical model element → FHIR mapping

This page maps each element from the PROTECT-CHILD logical models (StructureDefinition kind = logical) to the FHIR profiles/resources implemented in this IG.

How to read this table:

Logical element: element name in the logical model
FHIR profile: the primary FHIR profile where the data is represented
FHIR element path: where the value lives (direct element or extension[...] slice)
Some patient/donor facts are represented as Observations grouped in a PatientObservations List (see patient-observations.fsh).

Patient logical model

Logical model: patient-lm Primary FHIR profile: patient-transplant (Patient)

Logical model representing the PROTECT-CHILD data model entity `patient`.

Logical element	Card.	Logical type	FHIR profile	FHIR element path	Notes
`patientId`	`1..1`	`string`	patient-transplant	`Patient.identifier.value`	Maps PROTECT-CHILD patient_id.
`gender`	`0..1`	`code`	patient-transplant	`Patient.gender`
`birthdate`	`0..1`	`date`	patient-transplant	`Patient.birthDate`
`currentAge`	`0..1`	`integer`	patient-transplant	`(derived)`	Derived from Patient.birthDate
`bloodGroup`	`0..1`	`CodeableConcept`	patient-abo-group-observation	`Observation.valueCodeableConcept`
`rhFactor`	`0..1`	`CodeableConcept`	patient-rh-factor-observation	`Observation.valueCodeableConcept`
`maxPra`	`0..1`	`integer`	patient-pra-observation	`Observation.valueInteger (+ Observation.method = max/last)`	Integer 0–100.
`lastPra`	`0..1`	`integer`	patient-pra-observation	`Observation.valueInteger (+ Observation.method = max/last)`	Integer 0–100.
`allograftHlaClassIAb`	`0..1`	`CodeableConcept`	patient-hla-typing-class-i-observation	`Observation.component`
`allograftHlaClassIiAb`	`0..1`	`CodeableConcept`	patient-hla-typing-class-ii-observation	`Observation.component`
`dateHistologicalDiag`	`0..1`	`dateTime`	patient-histological-diagnosis-date-observation	`Observation.valueDateTime`
`dateDiagLiverDisease`	`0..1`	`dateTime`	patient-liver-disease-diagnosis-observation	`Observation.effectiveDateTime`
`diagLiverDisease`	`0..1`	`string`	patient-liver-disease-diagnosis-observation	`Observation.valueCodeableConcept`
`diagLiverDiseaseExtra`	`0..1`	`string`	patient-liver-disease-diagnosis-observation	`Observation.note.text`
`dateDiagRenalDisease`	`0..1`	`dateTime`	patient-renal-disease-diagnosis-observation	`Observation.effectiveDateTime`
`diagRenalDisease`	`0..1`	`string`	patient-renal-disease-diagnosis-observation	`Observation.valueCodeableConcept`
`diagRenalDiseaseExtra`	`0..1`	`string`	patient-renal-disease-diagnosis-observation	`Observation.note.text`

Donor logical model

Logical model: donor-lm Primary FHIR profile: donor (Patient)

Logical model representing the PROTECT-CHILD data model entity `donor`.

Logical element	Card.	Logical type	FHIR profile	FHIR element path	Notes
`donorId`	`1..1`	`string`	donor	`Patient.identifier.value`	Maps donor_id.
`age`	`0..1`	`integer`	donor	`(derived)`	Derived from Patient.birthDate
`type`	`0..1`	`CodeableConcept`	donor	`Patient.extension[donorType].valueCodeableConcept`
`liverType`	`0..1`	`CodeableConcept`	donor-liver-type-observation	`Observation.valueCodeableConcept`
`bloodGroup`	`0..1`	`CodeableConcept`	patient-abo-group-observation	`Observation.valueCodeableConcept`
`rhFactor`	`0..1`	`CodeableConcept`	patient-rh-factor-observation	`Observation.valueCodeableConcept`
`preKtxDialysisType`	`0..1`	`CodeableConcept`	donor-pre-ktx-dialysis-type-observation	`Observation.valueCodeableConcept`
`allograftHlaClassIAb`	`0..1`	`CodeableConcept`	patient-hla-typing-class-i-observation	`Observation.component`
`allograftHlaClassIiAb`	`0..1`	`CodeableConcept`	patient-hla-typing-class-ii-observation	`Observation.component`

Visit logical model

Logical model: visit-lm Primary FHIR profile: visit (Encounter)

Logical model representing the PROTECT-CHILD data model entity `visit`.

Logical element	Card.	Logical type	FHIR profile	FHIR element path	Notes
`visitId`	`1..1`	`string`	visit	`Encounter.identifier.value`
`patientId`	`0..1`	`string`	visit	`Encounter.subject`	Reference to PatientTransplant.
`transplantId`	`0..1`	`string`	visit	`Encounter.extension[transplant_id].value[x]`
`bioSampleId`	`0..1`	`string`	visit	`Encounter.extension[bio_sample_id].value[x]`
`preMedicationId`	`0..1`	`string`	visit	`Encounter.extension[pre_medication_id].value[x]`
`clinicalVariableId`	`0..1`	`string`	visit	`Encounter.extension[clinical_variable_id].value[x]`
`concomitantEpisodeId`	`0..1`	`string`	visit	`Encounter.extension[concomitant_episode_id].value[x]`
`microbiologyId`	`0..1`	`string`	visit	`Encounter.extension[microbiology_id].value[x]`
`patInstInvId`	`0..1`	`string`	visit	`Encounter.extension[pat_inst_inv_id].value[x]`
`immIndPatId`	`0..1`	`string`	visit	`Encounter.extension[imm_ind_pat_id].value[x]`
`immMainPatId`	`0..1`	`string`	visit	`Encounter.extension[imm_main_pat_id].value[x]`
`labResultId`	`0..1`	`string`	visit	`Encounter.extension[lab_result_id].value[x]`
`postEventId`	`0..1`	`string`	visit	`Encounter.extension[post_event_id].value[x]`
`outcomeId`	`0..1`	`string`	visit	`Encounter.extension[outcome_id].value[x]`
`date`	`0..1`	`dateTime`	visit	`Encounter.period.start`
`visitType`	`0..1`	`CodeableConcept`	visit	`Encounter.type[0]`

Transplant logical model

Logical model: transplant-lm Primary FHIR profile: transplant (Encounter)

Logical model representing the PROTECT-CHILD data model entity `transplant`.

Logical element	Card.	Logical type	FHIR profile	FHIR element path	Notes
`transplantId`	`1..1`	`string`	transplant	`Encounter.identifier.value`
`patientId`	`0..1`	`string`	transplant	`Encounter.subject`	Reference to PatientTransplant.
`donorId`	`0..1`	`string`	transplant	`Encounter.extension[donor_id].valueReference`	Reference to Donor.
`dRWeightRation`	`0..1`	`string`	transplant	`Encounter.extension[d_r_weight_ration].value[x]`
`vesselMismatchDR`	`0..1`	`string`	transplant	`Encounter.extension[vessel_mismatch_dr].value[x]`
`coldIschemiaTime`	`0..1`	`dateTime`	transplant	`Encounter.extension[cold_ischemia_time].value[x]`
`txType`	`0..1`	`CodeableConcept`	transplant	`Encounter.type[0]`
`dateTx`	`0..1`	`dateTime`	transplant	`Encounter.period.start`
`timeDiagToTx`	`0..1`	`dateTime`	transplant	`Encounter.extension[time_diag_to_tx].value[x]`
`1WarmIschemiaTime`	`0..1`	`dateTime`	transplant	`Encounter.extension[1_warm_ischemia_time].value[x]`
`2WarmIschemiaTime`	`0..1`	`dateTime`	transplant	`Encounter.extension[2_warm_ischemia_time].value[x]`
`vascularAnomalies`	`0..1`	`string`	transplant	`Encounter.extension[vascular_anomalies].value[x]`
`typeSurgicalBiliaryAnastomosis`	`0..1`	`CodeableConcept`	transplant	`Encounter.extension[type_surgical_biliary_anastomosis].value[x]`
`intraoperativeComplications`	`0..1`	`string`	transplant	`Encounter.extension[intraoperative_complications].value[x]`
`intraoperativeComplicationsOther`	`0..1`	`string`	transplant	`Encounter.extension[intraoperative_complications_other].value[x]`
`nephrectomyOriginalKidney`	`0..1`	`string`	transplant	`Encounter.extension[nephrectomy_original_kidney].value[x]`
`kidneySide`	`0..1`	`CodeableConcept`	transplant	`Encounter.extension[kidney_side].value[x]`

BioSample logical model

Logical model: bio-sample-lm Primary FHIR profile: biosample (Specimen)

Logical model representing the PROTECT-CHILD data model entity `bio_sample`.

Logical element	Card.	Logical type	FHIR profile	FHIR element path	Notes
`bioSampleId`	`1..1`	`string`	biosample	`Specimen.identifier.value`
`patientId`	`0..1`	`string`	biosample	`Specimen.subject`	Reference to PatientTransplant.
`genomicTestId`	`0..1`	`string`	biosample	`Specimen.extension[genomic_test_id].value[x]`
`epigenomeStudyId`	`0..1`	`string`	biosample	`Specimen.extension[epigenome_study_id].value[x]`
`methylomicStudyId`	`0..1`	`string`	biosample	`Specimen.extension[methylomic_study_id].value[x]`
`collectionDate`	`0..1`	`dateTime`	biosample	`Specimen.collection.collectedDateTime`
`sendIngemmDate`	`0..1`	`dateTime`	biosample	`Specimen.extension[send_ingemm_date].value[x]`
`tissueType`	`0..1`	`CodeableConcept`	biosample	`Specimen.type`
`dnaConcentration`	`0..1`	`decimal`	biosample	`Specimen.extension[dna_concentration].value[x]`

ReferenceGenome logical model

Logical model: reference-genome-lm Primary FHIR profile: reference-genome (Basic)

Logical model representing the PROTECT-CHILD data model entity `reference_genome`.

Logical element	Card.	Logical type	FHIR profile	FHIR element path
`referenceGenomeId`	`1..1`	`string`	reference-genome	`Basic.identifier.value`
`buildName`	`0..1`	`string`	reference-genome	`Basic.code`
`fastaPath`	`0..1`	`string`	reference-genome	`Basic.extension[fasta_path].value[x]`

TargetRegion logical model

Logical model: target-region-lm Primary FHIR profile: target-region (Basic)

Logical model representing the PROTECT-CHILD data model entity `target_region`.

Logical element	Card.	Logical type	FHIR profile	FHIR element path
`targetRegionId`	`1..1`	`string`	target-region	`Basic.identifier.value`
`genomicTestId`	`0..1`	`string`	target-region	`Basic.extension[genomicTestId].value[x]`
`hgncId`	`0..1`	`string`	target-region	`Basic.extension[hgncId].value[x]`
`hgncSymbol`	`0..1`	`string`	target-region	`Basic.extension[hgncSymbol].value[x]`
`chromosomeId`	`0..1`	`string`	target-region	`Basic.extension[chromosomeId].value[x]`
`startPosition`	`0..1`	`string`	target-region	`Basic.extension[startPosition].value[x]`
`endPosition`	`0..1`	`string`	target-region	`Basic.extension[endPosition].value[x]`

GenomicTest logical model

Logical model: genomic-test-lm Primary FHIR profile: genomic-test (Basic)

Logical model representing the PROTECT-CHILD data model entity `genomic_test`.

Logical element	Card.	Logical type	FHIR profile	FHIR element path
`genomicTestId`	`1..1`	`string`	genomic-test	`Basic.identifier.value`
`referenceGenomeId`	`0..1`	`string`	genomic-test	`Basic.extension[referenceGenomeId].value[x]`
`testName`	`0..1`	`string`	genomic-test	`Basic.extension[testName].value[x]`
`testVersion`	`0..1`	`string`	genomic-test	`Basic.extension[testVersion].value[x]`
`sequencingDevice`	`0..1`	`string`	genomic-test	`Basic.extension[sequencingDevice].value[x]`
`targetCapture`	`0..1`	`string`	genomic-test	`Basic.extension[targetCapture].value[x]`
`readType`	`0..1`	`CodeableConcept`	genomic-test	`Basic.extension[readType].value[x]`
`readLength`	`0..1`	`string`	genomic-test	`Basic.extension[readLength].value[x]`
`meanTargetCoverage`	`0..1`	`integer`	genomic-test	`Basic.extension[meanTargetCoverage].value[x]`
`perTargetBaseCover100x`	`0..1`	`string`	genomic-test	`Basic.extension[perTargetBaseCover100x].value[x]`
`alignmentTools`	`0..1`	`string`	genomic-test	`Basic.extension[alignmentTools].value[x]`
`variantCallingTools`	`0..1`	`string`	genomic-test	`Basic.extension[variantCallingTools].value[x]`
`chromosomeCorrdinate`	`0..1`	`string`	genomic-test	`Basic.extension[chromosomeCorrdinate].value[x]`
`annotationTools`	`0..1`	`string`	genomic-test	`Basic.extension[annotationTools].value[x]`
`annotationDatabases`	`0..1`	`string`	genomic-test	`Basic.extension[annotationDatabases].value[x]`

VariantOccurrence logical model

Logical model: variant-occurrence-lm Primary FHIR profile: variant-occurrence (Basic)

Logical model representing the PROTECT-CHILD data model entity `variant_occurrence`.

Logical element	Card.	Logical type	FHIR profile	FHIR element path
`variantOccurrenceId`	`1..1`	`string`	variant-occurrence	`Basic.identifier.value`
`targetRegionId`	`0..1`	`string`	variant-occurrence	`Basic.extension[targetRegionId].value[x]`
`referenceSequence`	`0..1`	`string`	variant-occurrence	`Basic.extension[referenceSequence].value[x]`
`rsId`	`0..1`	`string`	variant-occurrence	`Basic.extension[rsId].value[x]`
`referenceAllele`	`0..1`	`string`	variant-occurrence	`Basic.extension[referenceAllele].value[x]`
`alternateAllele`	`0..1`	`string`	variant-occurrence	`Basic.extension[alternateAllele].value[x]`
`hgvsC`	`0..1`	`string`	variant-occurrence	`Basic.extension[hgvsC].value[x]`
`hgvsP`	`0..1`	`string`	variant-occurrence	`Basic.extension[hgvsP].value[x]`
`variantReadDepth`	`0..1`	`string`	variant-occurrence	`Basic.extension[variantReadDepth].value[x]`
`variantExonNumber`	`0..1`	`string`	variant-occurrence	`Basic.extension[variantExonNumber].value[x]`
`copyNumber`	`0..1`	`string`	variant-occurrence	`Basic.extension[copyNumber].value[x]`
`cnvLocus`	`0..1`	`string`	variant-occurrence	`Basic.extension[cnvLocus].value[x]`
`fusionBreakpoint`	`0..1`	`string`	variant-occurrence	`Basic.extension[fusionBreakpoint].value[x]`
`fusionSupportingReads`	`0..1`	`string`	variant-occurrence	`Basic.extension[fusionSupportingReads].value[x]`
`sequenceAlteration`	`0..1`	`string`	variant-occurrence	`Basic.extension[sequenceAlteration].value[x]`
`variantFeature`	`0..1`	`string`	variant-occurrence	`Basic.extension[variantFeature].value[x]`
`geneticOrigin`	`0..1`	`string`	variant-occurrence	`Basic.extension[geneticOrigin].value[x]`
`genotype`	`0..1`	`CodeableConcept`	variant-occurrence	`Basic.extension[genotype].value[x]`

VariantAnnotation logical model

Logical model: variant-annotation-lm Primary FHIR profile: variant-annotation (Basic)

Logical model representing the PROTECT-CHILD data model entity `variant_annotation`.

Logical element	Card.	Logical type	FHIR profile	FHIR element path
`variantAnnotationId`	`1..1`	`string`	variant-annotation	`Basic.identifier.value`
`variantOccurrenceId`	`0..1`	`string`	variant-annotation	`Basic.extension[variantOccurrenceId].value[x]`
`annotationDatabase`	`0..1`	`string`	variant-annotation	`Basic.extension[annotationDatabase].value[x]`
`variantOrigin`	`0..1`	`string`	variant-annotation	`Basic.extension[variantOrigin].value[x]`
`variantPathogeny`	`0..1`	`string`	variant-annotation	`Basic.extension[variantPathogeny].value[x]`
`variantClassLevel`	`0..1`	`decimal`	variant-annotation	`Basic.extension[variantClassLevel].value[x]`
`variantTierLevel`	`0..1`	`decimal`	variant-annotation	`Basic.extension[variantTierLevel].value[x]`
`alleleFrequency`	`0..1`	`string`	variant-annotation	`Basic.extension[alleleFrequency].value[x]`
`medication`	`0..1`	`string`	variant-annotation	`Basic.extension[medication].value[x]`

EpigenomeStudy logical model

Logical model: epigenome-study-lm Primary FHIR profile: epigenome-study (Basic)

Logical model representing the PROTECT-CHILD data model entity `epigenome_study`.

Logical element	Card.	Logical type	FHIR profile	FHIR element path
`epigenomeStudyId`	`1..1`	`string`	epigenome-study	`Basic.identifier.value`
`genomicTestId`	`0..1`	`string`	epigenome-study	`Basic.extension[genomicTestId].value[x]`
`bisulfiteReferenceKit`	`0..1`	`string`	epigenome-study	`Basic.extension[bisulfiteReferenceKit].value[x]`
`bisulfiteDate`	`0..1`	`dateTime`	epigenome-study	`Basic.extension[bisulfiteDate].value[x]`
`ageAtDnaExtraction`	`0..1`	`integer`	epigenome-study	`Basic.extension[ageAtDNAExtraction].valueDecimal`
`arrayDate`	`0..1`	`dateTime`	epigenome-study	`Basic.extension[arrayDate].value[x]`
`snpReaderDevice`	`0..1`	`string`	epigenome-study	`Basic.extension[snpReaderDevice].value[x]`
`sampleType`	`0..1`	`CodeableConcept`	epigenome-study	`Basic.extension[sampleType].value[x]`
`poolId`	`0..1`	`string`	epigenome-study	`Basic.extension[poolId].value[x]`
`sampleId`	`0..1`	`string`	epigenome-study	`Basic.extension[sampleId].value[x]`
`sentrixBarcodearray`	`0..1`	`string`	epigenome-study	`Basic.extension[sentrixBarcodeArray].valueString`
`sentrixPosition`	`0..1`	`string`	epigenome-study	`Basic.extension[sentrixPosition].value[x]`
`chipType`	`0..1`	`CodeableConcept`	epigenome-study	`Basic.extension[chipType].value[x]`
`manifestNumber`	`0..1`	`string`	epigenome-study	`Basic.extension[manifestNumber].value[x]`
`scanDate`	`0..1`	`dateTime`	epigenome-study	`Basic.extension[scanDate].value[x]`
`rawData`	`0..1`	`string`	epigenome-study	`Basic.extension[rawData].value[x]`
`targetDiseaseId`	`0..1`	`string`	epigenome-study	`Basic.extension[targetDiseaseId].value[x]`

MethylomicStudy logical model

Logical model: methylomic-study-lm Primary FHIR profile: methylomic-study (Basic)

Logical model representing the PROTECT-CHILD data model entity `methylomic_study`.

Logical element	Card.	Logical type	FHIR profile	FHIR element path
`methylomicStudyId`	`1..1`	`string`	methylomic-study	`Basic.identifier.value`
`referenceGenomeId`	`0..1`	`string`	methylomic-study	`Basic.extension[referenceGenomeId].value[x]`
`targetRegionId`	`0..1`	`string`	methylomic-study	`Basic.extension[targetRegionId].value[x]`
`betaValue`	`0..1`	`decimal`	methylomic-study	`Basic.extension[betaValue].value[x]`
`mValue`	`0..1`	`decimal`	methylomic-study	`Basic.extension[mValue].value[x]`
`detectionPValue`	`0..1`	`decimal`	methylomic-study	`Basic.extension[detectionPValue].value[x]`
`readCount`	`0..1`	`string`	methylomic-study	`Basic.extension[readCount].value[x]`
`methylatedReads`	`0..1`	`string`	methylomic-study	`Basic.extension[methylatedReads].value[x]`

PreMedication logical model

Logical model: pre-medication-lm Primary FHIR profile: pre-medication (Basic)

Logical model representing the PROTECT-CHILD data model entity `pre_medication`.

Logical element	Card.	Logical type	FHIR profile	FHIR element path
`preMedicationId`	`1..1`	`string`	pre-medication	`Basic.identifier.value`
`patientId`	`0..1`	`string`	pre-medication	`Basic.extension[patient_id].value[x]`
`antihypertensiveTreatment`	`0..1`	`string`	pre-medication	`Basic.extension[antihypertensive_treatment].value[x]`
`rituximab`	`0..1`	`string`	pre-medication	`Basic.extension[rituximab].value[x]`
`antiviralPhrophylaxis`	`0..1`	`string`	pre-medication	`Basic.extension[antiviral_phrophylaxis].value[x]`
`otherMedications`	`0..1`	`string`	pre-medication	`Basic.extension[other_medications].value[x]`

ClinicalVariable logical model

Logical model: clinical-variable-lm Primary FHIR profile: clinical-variable (Basic)

Logical model representing the PROTECT-CHILD data model entity `clinical_variable`.

Logical element	Card.	Logical type	FHIR profile	FHIR element path
`clinicalVariableId`	`1..1`	`string`	clinical-variable	`Basic.identifier.value`
`patientId`	`0..1`	`string`	clinical-variable	`Basic.extension[patientId].value[x]`
`date`	`0..1`	`dateTime`	clinical-variable	`Basic.extension[date].value[x]`
`weight`	`0..1`	`string`	clinical-variable	`Basic.extension[weight].value[x]`
`height`	`0..1`	`string`	clinical-variable	`Basic.extension[height].value[x]`
`systolicBloodPressure`	`0..1`	`string`	clinical-variable	`Basic.extension[systolicBloodPressure].value[x]`
`diastolicBloodPressure`	`0..1`	`string`	clinical-variable	`Basic.extension[diastolicBloodPressure].value[x]`
`heartRate`	`0..1`	`string`	clinical-variable	`Basic.extension[heartRate].value[x]`
`oxygenSaturation`	`0..1`	`string`	clinical-variable	`Basic.extension[oxygenSaturation].value[x]`
`temperature`	`0..1`	`string`	clinical-variable	`Basic.extension[temperature].value[x]`

ConcomitantDisease logical model

Logical model: concomitant-disease-lm Primary FHIR profile: concomitant-disease (Basic)

Logical model representing the PROTECT-CHILD data model entity `concomitant_disease`.

Logical element	Card.	Logical type	FHIR profile	FHIR element path	Notes
`concomitantDiseaseId`	`1..1`	`string`	concomitant-disease	`Basic.identifier.value`
`name`	`0..1`	`string`	concomitant-disease	`Basic.extension[concomitantDiseaseName].valueString`

ConcomitantMedication logical model

Logical model: concomitant-medication-lm Primary FHIR profile: concomitant-medication (Basic)

Logical model representing the PROTECT-CHILD data model entity `concomitant_medication`.

Logical element	Card.	Logical type	FHIR profile	FHIR element path
`concomitantMedicationId`	`1..1`	`string`	concomitant-medication	`Basic.identifier.value`
`concomitantEpisodeId`	`0..1`	`string`	concomitant-medication	`Basic.extension[concomitantEpisodeId].value[x]`
`medication`	`0..1`	`string`	concomitant-medication	`Basic.extension[medication].value[x]`

ConcomitantEpisode logical model

Logical model: concomitant-episode-lm Primary FHIR profile: concomitant-episode (Basic)

Logical model representing the PROTECT-CHILD data model entity `concomitant_episode`.

Logical element	Card.	Logical type	FHIR profile	FHIR element path
`concomitantEpisodeId`	`1..1`	`string`	concomitant-episode	`Basic.identifier.value`
`concomitantDiseaseId`	`0..1`	`string`	concomitant-episode	`Basic.extension[concomitantDiseaseId].value[x]`
`patientId`	`0..1`	`string`	concomitant-episode	`Basic.extension[patientId].value[x]`
`date`	`0..1`	`dateTime`	concomitant-episode	`Basic.extension[date].value[x]`
`description`	`0..1`	`string`	concomitant-episode	`Basic.extension[description].value[x]`

Microbiology logical model

Logical model: microbiology-lm Primary FHIR profile: microbiology (Observation)

Logical model representing the PROTECT-CHILD data model entity `microbiology`.

Logical element	Card.	Logical type	FHIR profile	FHIR element path
`microbiologyId`	`1..1`	`string`	microbiology	`Observation.identifier.value`
`patientId`	`0..1`	`string`	microbiology	`Observation.extension[patient_id].value[x]`
`donorId`	`0..1`	`string`	microbiology	`Observation.extension[donor_id].value[x]`
`ebvDna`	`0..1`	`string`	microbiology	`Observation.extension[ebv_dna].value[x]`
`ebvIgmAntiEa`	`0..1`	`string`	microbiology	`Observation.extension[ebv_igm_anti_ea].value[x]`
`ebvIgmAntiVca`	`0..1`	`string`	microbiology	`Observation.extension[ebv_igm_anti_vca].value[x]`
`ebvIggAntiVca`	`0..1`	`string`	microbiology	`Observation.extension[ebv_igg_anti_vca].value[x]`
`ebvIggEbna`	`0..1`	`string`	microbiology	`Observation.extension[ebv_igg_ebna].value[x]`
`cmvDna`	`0..1`	`string`	microbiology	`Observation.extension[cmv_dna].value[x]`
`cmvIgm`	`0..1`	`string`	microbiology	`Observation.extension[cmv_igm].value[x]`
`cmvIgg`	`0..1`	`string`	microbiology	`Observation.extension[cmv_igg].value[x]`
`parvovirusB19Dna`	`0..1`	`string`	microbiology	`Observation.extension[parvovirus_b19_dna].value[x]`
`parvovirusB19DnaIgg`	`0..1`	`string`	microbiology	`Observation.extension[parvovirus_b19_dna_igg].value[x]`
`parvovirusB19DnaIgm`	`0..1`	`string`	microbiology	`Observation.extension[parvovirus_b19_dna_igm].value[x]`
`hsvIgg`	`0..1`	`string`	microbiology	`Observation.extension[hsv_igg].value[x]`
`hsvIgm`	`0..1`	`string`	microbiology	`Observation.extension[hsv_igm].value[x]`
`adenovirusIgg`	`0..1`	`string`	microbiology	`Observation.extension[adenovirus_igg].value[x]`
`adenovirusIgm`	`0..1`	`string`	microbiology	`Observation.extension[adenovirus_igm].value[x]`
`vzvIgg`	`0..1`	`string`	microbiology	`Observation.extension[vzv_igg].value[x]`
`vzvIgm`	`0..1`	`string`	microbiology	`Observation.extension[vzv_igm].value[x]`
`bloodBkvDna`	`0..1`	`string`	microbiology	`Observation.extension[blood_bkv_dna].value[x]`
`urineBkvDna`	`0..1`	`string`	microbiology	`Observation.extension[urine_bkv_dna].value[x]`
`bkvDnaKidneyBiopsy`	`0..1`	`string`	microbiology	`Observation.extension[bkv_dna_kidney_biopsy].value[x]`
`bkvFishKidneyBiopsy`	`0..1`	`string`	microbiology	`Observation.extension[bkv_fish_kidney_biopsy].value[x]`

InstrumentalInvestigation logical model

Logical model: instrumental-investigation-lm Primary FHIR profile: instrumental-investigation (Basic)

Logical model representing the PROTECT-CHILD data model entity `instrumental_investigation`.

Logical element	Card.	Logical type	FHIR profile	FHIR element path	Notes
`instrumentalInvestigationId`	`1..1`	`string`	instrumental-investigation	`Basic.identifier.value`
`name`	`0..1`	`string`	instrumental-investigation	`Basic.extension[name].value[x]`

PatInstInv logical model

Logical model: pat-inst-inv-lm Primary FHIR profile: patient-instrumental-investigation (Observation)

Logical model representing the PROTECT-CHILD data model entity `pat_inst_inv`.

Logical element	Card.	Logical type	FHIR profile	FHIR element path
`patInstInvId`	`1..1`	`string`	patient-instrumental-investigation	`Observation.identifier.value`
`instrumentalInvestigationId`	`0..1`	`string`	patient-instrumental-investigation	`Observation.extension[instrumental_investigation_id].value[x]`
`patientId`	`0..1`	`string`	patient-instrumental-investigation	`Observation.extension[patient_id].value[x]`
`date`	`0..1`	`dateTime`	patient-instrumental-investigation	`Observation.effectiveDateTime`
`result`	`0..1`	`string`	patient-instrumental-investigation	`Observation.extension[result].value[x]`
`observations`	`0..1`	`string`	patient-instrumental-investigation	`Observation.note.text`

Immunosuppressant logical model

Logical model: immunosuppressant-lm Primary FHIR profile: immunosuppressant (Basic)

Logical model representing the PROTECT-CHILD data model entity `immunosuppressant`.

Logical element	Card.	Logical type	FHIR profile	FHIR element path	Notes
`immId`	`1..1`	`string`	immunosuppressant	`Basic.identifier.value`
`name`	`0..1`	`string`	immunosuppressant	`Basic.extension[name].value[x]`

ImmIndPat logical model

Logical model: imm-ind-pat-lm Primary FHIR profile: immunosuppressive-induction-patient (Basic)

Logical model representing the PROTECT-CHILD data model entity `imm_ind_pat`.

Logical element	Card.	Logical type	FHIR profile	FHIR element path	Notes
`immIndPatId`	`1..1`	`string`	immunosuppressive-induction-patient	`Basic.identifier.value`
`immId`	`0..1`	`string`	immunosuppressive-induction-patient	`Basic.extension[immId].valueReference`
`patientId`	`0..1`	`string`	immunosuppressive-induction-patient	`Basic.extension[patientId].valueReference`
`dose`	`0..1`	`decimal`	immunosuppressive-induction-patient	`Basic.extension[dose].valueQuantity`	Dose quantity (value + UCUM unit).
`unit`	`0..1`	`CodeableConcept`	immunosuppressive-induction-patient	`Basic.extension[dose].valueQuantity.code`	Unit is carried in the dose Quantity (UCUM code).

ImmMainPat logical model

Logical model: imm-main-pat-lm Primary FHIR profile: immunosuppressive-maintenance-patient (Basic)

Logical model representing the PROTECT-CHILD data model entity `imm_main_pat`.

Logical element	Card.	Logical type	FHIR profile	FHIR element path	Notes
`immMainPatId`	`1..1`	`string`	immunosuppressive-maintenance-patient	`Basic.identifier.value`
`patientId`	`0..1`	`string`	immunosuppressive-maintenance-patient	`Basic.extension[patient_id].valueReference`
`immId`	`0..1`	`string`	immunosuppressive-maintenance-patient	`Basic.extension[immunosuppressant_id].valueReference`
`unitId`	`0..1`	`string`	immunosuppressive-maintenance-patient	`Basic.extension[dose].valueQuantity.code`	Unit is carried in the dose Quantity (UCUM code).
`dose`	`0..1`	`decimal`	immunosuppressive-maintenance-patient	`Basic.extension[dose].valueQuantity`	Dose quantity (value + UCUM unit).
`preDoseLevel`	`0..1`	`decimal`	immunosuppressive-maintenance-patient	`Basic.extension[pre_dose_level].valueQuantity`	Pre-dose (trough) drug level as Quantity with UCUM unit.
`csa2hPostDoseLevel`	`0..1`	`decimal`	immunosuppressive-maintenance-patient	`Basic.extension[csa2h_post_dose_level].valueQuantity`	2-hour post-dose drug level (C2), Quantity with UCUM unit.
`auc`	`0..1`	`decimal`	immunosuppressive-maintenance-patient	`Basic.extension[auc].valueQuantity`	Pharmacokinetic AUC, Quantity with UCUM unit.
`startDate`	`0..1`	`dateTime`	immunosuppressive-maintenance-patient	`Basic.extension[start_date].valueDate`
`endDate`	`0..1`	`dateTime`	immunosuppressive-maintenance-patient	`Basic.extension[end_date].valueDate`

LabTest logical model

Logical model: lab-test-lm Primary FHIR profile: lab-test (Basic)

Logical model representing the PROTECT-CHILD data model entity `lab_test`.

Logical element	Card.	Logical type	FHIR profile	FHIR element path
`labTestId`	`1..1`	`string`	lab-test	`Basic.identifier.value`
`unitId`	`0..1`	`string`	lab-test	`Basic.extension[unitId].value[x]`
`name`	`0..1`	`string`	lab-test	`Basic.extension[name].value[x]`

Unit logical model

Logical model: unit-lm Primary FHIR profile: FHIR datatype: Quantity (UCUM; system http://unitsofmeasure.org)

Logical model representing the PROTECT-CHILD data model entity `unit`.

Logical element	Card.	Logical type	FHIR profile	FHIR element path	Notes
`unitId`	`1..1`	`string`	Quantity	`Quantity.code`	Use UCUM where possible (code with system http://unitsofmeasure.org).
`ucum`	`0..1`	`code`	Quantity	`Quantity.system + Quantity.code`	UCUM: system fixed to http://unitsofmeasure.org; code is the UCUM unit.
`label`	`0..1`	`string`	Quantity	`Quantity.unit`	Human-readable unit display (e.g., mg/kg).

LabResult logical model

Logical model: lab-result-lm Primary FHIR profile: lab-result-observation (Observation)

Logical model representing the PROTECT-CHILD data model entity `lab_result`.

Logical element	Card.	Logical type	FHIR profile	FHIR element path	Notes
`labResultId`	`1..1`	`string`	lab-result-observation	`Observation.identifier.value`
`labTestId`	`0..1`	`string`	lab-result-observation	`Observation.extension[lab_test_id].valueReference`	Reference to LabTest.
`patientId`	`0..1`	`string`	lab-result-observation	`Observation.extension[patient_id].valueReference`	Reference to PatientTransplant.
`unitId`	`0..1`	`string`	lab-result-observation	`Observation.valueQuantity.code`	From LabResultUnitVS (or UCUM/CodeSystem).
`date`	`0..1`	`dateTime`	lab-result-observation	`Observation.effectiveDateTime`
`value`	`0..1`	`decimal`	lab-result-observation	`Observation.valueQuantity.value`

MarkImmFunc logical model

Logical model: mark-imm-func-lm Primary FHIR profile: marker-immune-function (Basic)

Logical model representing the PROTECT-CHILD data model entity `mark_imm_func`.

Logical element	Card.	Logical type	FHIR profile	FHIR element path
`markImmFuncId`	`1..1`	`string`	marker-immune-function	`Basic.identifier.value`
`patientId`	`0..1`	`string`	marker-immune-function	`Basic.extension[patientId].value[x]`
`hlaAntibodyClass`	`0..1`	`CodeableConcept`	marker-immune-function	`Basic.extension[hlaAntibodyClass].value[x]`
`mfiValue`	`0..1`	`decimal`	marker-immune-function	`Basic.extension[mfiValue].value[x]`
`dsa`	`0..1`	`boolean`	marker-immune-function	`Basic.extension[dsa].value[x]`
`atr1`	`0..1`	`boolean`	marker-immune-function	`Basic.extension[atr1].value[x]`
`etar`	`0..1`	`boolean`	marker-immune-function	`Basic.extension[etar].value[x]`
`mica`	`0..1`	`boolean`	marker-immune-function	`Basic.extension[mica].value[x]`
`micb`	`0..1`	`boolean`	marker-immune-function	`Basic.extension[micb].value[x]`
`aecaOther`	`0..1`	`string`	marker-immune-function	`Basic.extension[aecaOther].value[x]`

PostEvent logical model

Logical model: post-event-lm Primary FHIR profile: post-event (Basic)

Logical model representing the PROTECT-CHILD data model entity `post_event`.

Logical element	Card.	Logical type	FHIR profile	FHIR element path
`postEventId`	`1..1`	`string`	post-event	`Basic.identifier.value`
`postEventTypeId`	`0..1`	`string`	post-event	`Basic.extension[postEventTypeId].value[x]`
`patientId`	`0..1`	`string`	post-event	`Basic.extension[patientId].value[x]`
`onsetDate`	`0..1`	`dateTime`	post-event	`Basic.extension[onsetDate].value[x]`
`endDate`	`0..1`	`dateTime`	post-event	`Basic.extension[endDate].value[x]`
`description`	`0..1`	`string`	post-event	`Basic.extension[description].value[x]`

PostEventType logical model

Logical model: post-event-type-lm Primary FHIR profile: post-event-type (Basic)

Logical model representing the PROTECT-CHILD data model entity `post_event_type`.

Logical element	Card.	Logical type	FHIR profile	FHIR element path	Notes
`postEventTypeId`	`1..1`	`string`	post-event-type	`Basic.identifier.value`
`name`	`0..1`	`string`	post-event-type	`Basic.extension[name].value[x]`

OutcomeType logical model

Logical model: outcome-type-lm Primary FHIR profile: outcome-type (Basic)

Logical model representing the PROTECT-CHILD data model entity `outcome_type`.

Logical element	Card.	Logical type	FHIR profile	FHIR element path	Notes
`outcomeTypeId`	`1..1`	`string`	outcome-type	`Basic.identifier.value`
`name`	`0..1`	`string`	outcome-type	`Basic.extension[name].value[x]`

Outcome logical model

Logical model: outcome-lm Primary FHIR profile: outcome (Basic)

Logical model representing the PROTECT-CHILD data model entity `outcome`.

Logical element	Card.	Logical type	FHIR profile	FHIR element path	Notes
`outcomeId`	`1..1`	`string`	outcome	`Basic.identifier.value`
`outcomeTypeId`	`0..1`	`string`	outcome	`Basic.extension[outcomeTypeId].value[x]`
`patientId`	`0..1`	`string`	outcome	`Basic.extension[patientId].value[x]`
`date`	`0..1`	`dateTime`	outcome	`Basic.extension[date].value[x]`
`preMedication`	`0..1`	`string`	outcome	`Basic.extension[preMedicationId].valueReference`	Reference to <a href=\"StructureDefinition-pre-medication.html\">pre-medication</a> (Basic).
`clinicalVariableId`	`0..1`	`string`	outcome	`Basic.extension[clinicalVariableId].value[x]`
`concomitantEpisodeId`	`0..1`	`string`	outcome	`Basic.extension[concomitantEpisodeId].value[x]`
`microbiologyId`	`0..1`	`string`	outcome	`Basic.extension[microbiologyId].value[x]`
`patInstInvId`	`0..1`	`string`	outcome	`Basic.extension[patInstInvId].value[x]`
`labTestId`	`0..1`	`string`	outcome	`Basic.extension[labTestId].value[x]`
`postEventId`	`0..1`	`string`	outcome	`Basic.extension[postEventId].value[x]`