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PROTECT-CHILD Pediatric Transplant Data Implementation Guide
0.1.0-ci-build -

PROTECT-CHILD Pediatric Transplant Data Implementation Guide
0.1.0-ci-build - ci-build

PROTECT-CHILD Pediatric Transplant Data Implementation Guide, published by Protect Child. This guide is not an authorized publication; it is the continuous build for version 0.1.0-ci-build built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/hl7-eu/protect-child/ and changes regularly. See the Directory of published versions

Resource Profile: Biological Sample Analysis Request

Official URL: https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/StructureDefinition/biosample-analysis-request Version: 0.1.0-ci-build
Draft as of 2026-06-05 Computable Name: BioSampleAnalysisRequest

A work order representing the intent to perform omics analysis (genomic or epigenomic) on a BioSample. One instance per analysis type per sample. Analysis intent (genomic_sample / epigenomic_sample) is carried here as ServiceRequest.code; Specimen.type remains free for specimen material type. specimen = Reference(BioSample).

Usages:

You can also check for usages in the FHIR IG Statistics

Formal Views of Profile Content

Description of Profiles, Differentials, Snapshots and how the different presentations work.

NameFlagsCard.TypeDescription & Constraints    Filter: Filtersdoco
.. ServiceRequest C 0..* ServiceRequest A request for a service to be performed
Constraints: prr-1
... implicitRules ?!Σ 0..1 uri A set of rules under which this content was created
... modifierExtension ?! 0..* Extension Extensions that cannot be ignored
... status ?!SΣ 1..1 code Use #active for samples awaiting analysis, #completed for processed samples
Binding: RequestStatus (required): The status of a service order.
... doNotPerform ?!Σ 0..1 boolean True if service/procedure should not be performed
... code SΣ 1..1 CodeableConcept genomic_sample / epigenomic_sample — analysis type (BioSampleAnalysisTypeVS)
Binding: Biological Sample Analysis Type ValueSet (required)
... subject SΣ 1..1 Reference(Transplant Recipient) Transplant recipient who provided the sample
... encounter SΣ 0..1 Reference(Visit) Visit at which this sample was collected (navigable via specimen → BioSample extension)
... specimen SΣ 1..1 Reference(Biological Sample) The BioSample to be analysed

doco Documentation for this format

Terminology Bindings

Path Status Usage ValueSet Version Source
ServiceRequest.status Base required RequestStatus 📍4.0.1 FHIR Std.
ServiceRequest.intent Base required RequestIntent 📍4.0.1 FHIR Std.
ServiceRequest.code Base required Biological Sample Analysis Type ValueSet 📦0.1.0-ci-build This IG

Constraints

Id Grade Path(s) Description Expression
dom-2 error ServiceRequest If the resource is contained in another resource, it SHALL NOT contain nested Resources contained.contained.empty()
dom-3 error ServiceRequest If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().as(canonical) | %resource.descendants().as(uri) | %resource.descendants().as(url))) or descendants().where(reference = '#').exists() or descendants().where(as(canonical) = '#').exists() or descendants().where(as(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4 error ServiceRequest If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5 error ServiceRequest If a resource is contained in another resource, it SHALL NOT have a security label contained.meta.security.empty()
dom-6 best practice ServiceRequest A resource should have narrative for robust management text.`div`.exists()
ele-1 error **ALL** elements All FHIR elements must have a @value or children hasValue() or (children().count() > id.count())
ext-1 error **ALL** extensions Must have either extensions or value[x], not both extension.exists() != value.exists()
prr-1 error ServiceRequest orderDetail SHALL only be present if code is present orderDetail.empty() or code.exists()

This structure is derived from ServiceRequest

NameFlagsCard.TypeDescription & Constraints    Filter: Filtersdoco
.. ServiceRequest 0..* ServiceRequest A request for a service to be performed
... status S 1..1 code Use #active for samples awaiting analysis, #completed for processed samples
... intent S 1..1 code Fixed to #order — each request is an analysis work order
Fixed Value: order
... code S 1..1 CodeableConcept genomic_sample / epigenomic_sample — analysis type (BioSampleAnalysisTypeVS)
Binding: Biological Sample Analysis Type ValueSet (required)
... encounter S 0..1 Reference(Visit) Visit at which this sample was collected (navigable via specimen → BioSample extension)
... specimen S 1..1 Reference(Biological Sample) The BioSample to be analysed

doco Documentation for this format

Terminology Bindings (Differential)

Path Status Usage ValueSet Version Source
ServiceRequest.code Base required Biological Sample Analysis Type ValueSet 📦0.1.0-ci-build This IG
NameFlagsCard.TypeDescription & Constraints    Filter: Filtersdoco
.. ServiceRequest C 0..* ServiceRequest A request for a service to be performed
Constraints: prr-1
... id Σ 0..1 id Logical id of this artifact
... meta Σ 0..1 Meta Metadata about the resource
... implicitRules ?!Σ 0..1 uri A set of rules under which this content was created
... language 0..1 code Language of the resource content
Binding: CommonLanguages (preferred): A human language.
Additional BindingsPurpose
AllLanguages Max Binding
... text 0..1 Narrative Text summary of the resource, for human interpretation
This profile does not constrain the narrative in regard to content, language, or traceability to data elements
... contained 0..* Resource Contained, inline Resources
... extension 0..* Extension Additional content defined by implementations
... modifierExtension ?! 0..* Extension Extensions that cannot be ignored
... identifier Σ 0..* Identifier Identifiers assigned to this order
... instantiatesCanonical Σ 0..* canonical(ActivityDefinition | PlanDefinition) Instantiates FHIR protocol or definition
... instantiatesUri Σ 0..* uri Instantiates external protocol or definition
... basedOn Σ 0..* Reference(CarePlan | ServiceRequest | MedicationRequest) What request fulfills
... replaces Σ 0..* Reference(ServiceRequest) What request replaces
... requisition Σ 0..1 Identifier Composite Request ID
... status ?!SΣ 1..1 code Use #active for samples awaiting analysis, #completed for processed samples
Binding: RequestStatus (required): The status of a service order.
... intent ?!SΣ 1..1 code Fixed to #order — each request is an analysis work order
Binding: RequestIntent (required): The kind of service request.
Fixed Value: order
... category Σ 0..* CodeableConcept Classification of service
Binding: ServiceRequestCategoryCodes (example): Classification of the requested service.
... priority Σ 0..1 code routine | urgent | asap | stat
Binding: RequestPriority (required): Identifies the level of importance to be assigned to actioning the request.
... doNotPerform ?!Σ 0..1 boolean True if service/procedure should not be performed
... code SΣ 1..1 CodeableConcept genomic_sample / epigenomic_sample — analysis type (BioSampleAnalysisTypeVS)
Binding: Biological Sample Analysis Type ValueSet (required)
... orderDetail ΣC 0..* CodeableConcept Additional order information
Binding: ServiceRequestOrderDetailsCodes (example): Codified order entry details which are based on order context.
... quantity[x] Σ 0..1 Service amount
.... quantityQuantity Quantity
.... quantityRatio Ratio
.... quantityRange Range
... subject SΣ 1..1 Reference(Transplant Recipient) Transplant recipient who provided the sample
... encounter SΣ 0..1 Reference(Visit) Visit at which this sample was collected (navigable via specimen → BioSample extension)
... occurrence[x] Σ 0..1 When service should occur
.... occurrenceDateTime dateTime
.... occurrencePeriod Period
.... occurrenceTiming Timing
... asNeeded[x] Σ 0..1 Preconditions for service
Binding: SNOMEDCTMedicationAsNeededReasonCodes (example): A coded concept identifying the pre-condition that should hold prior to performing a procedure. For example "pain", "on flare-up", etc.
.... asNeededBoolean boolean
.... asNeededCodeableConcept CodeableConcept
... authoredOn Σ 0..1 dateTime Date request signed
... requester Σ 0..1 Reference(Practitioner | PractitionerRole | Organization | Patient | RelatedPerson | Device) Who/what is requesting service
... performerType Σ 0..1 CodeableConcept Performer role
Binding: ParticipantRoles (example): Indicates specific responsibility of an individual within the care team, such as "Primary physician", "Team coordinator", "Caregiver", etc.
... performer Σ 0..* Reference(Practitioner | PractitionerRole | Organization | CareTeam | HealthcareService | Patient | Device | RelatedPerson) Requested performer
... locationCode Σ 0..* CodeableConcept Requested location
Binding: V3 Value SetServiceDeliveryLocationRoleType (example): A location type where services are delivered.
... locationReference Σ 0..* Reference(Location) Requested location
... reasonCode Σ 0..* CodeableConcept Explanation/Justification for procedure or service
Binding: ProcedureReasonCodes (example): Diagnosis or problem codes justifying the reason for requesting the service investigation.
... reasonReference Σ 0..* Reference(Condition | Observation | DiagnosticReport | DocumentReference) Explanation/Justification for service or service
... insurance 0..* Reference(Coverage | ClaimResponse) Associated insurance coverage
... supportingInfo 0..* Reference(Resource) Additional clinical information
... specimen SΣ 1..1 Reference(Biological Sample) The BioSample to be analysed
... bodySite Σ 0..* CodeableConcept Location on Body
Binding: SNOMEDCTBodyStructures (example): Codes describing anatomical locations. May include laterality.
... note 0..* Annotation Comments
... patientInstruction Σ 0..1 string Patient or consumer-oriented instructions
... relevantHistory 0..* Reference(Provenance) Request provenance

doco Documentation for this format

Terminology Bindings

Path Status Usage ValueSet Version Source
ServiceRequest.language Base preferred Common Languages 📍4.0.1 FHIR Std.
ServiceRequest.status Base required RequestStatus 📍4.0.1 FHIR Std.
ServiceRequest.intent Base required RequestIntent 📍4.0.1 FHIR Std.
ServiceRequest.category Base example Service Request Category Codes 📍4.0.1 FHIR Std.
ServiceRequest.priority Base required Request priority 📍4.0.1 FHIR Std.
ServiceRequest.code Base required Biological Sample Analysis Type ValueSet 📦0.1.0-ci-build This IG
ServiceRequest.orderDetail Base example Service Request Order Details Codes 📍4.0.1 FHIR Std.
ServiceRequest.asNeeded[x] Base example SNOMED CT Medication As Needed Reason Codes 📍4.0.1 FHIR Std.
ServiceRequest.performerType Base example Participant Roles 📍4.0.1 FHIR Std.
ServiceRequest.locationCode Base example V3 Value SetServiceDeliveryLocationRoleType 📦2014-03-26 FHIR Std.
ServiceRequest.reasonCode Base example Procedure Reason Codes 📍4.0.1 FHIR Std.
ServiceRequest.bodySite Base example SNOMED CT Body Structures 📍4.0.1 FHIR Std.

Constraints

Id Grade Path(s) Description Expression
dom-2 error ServiceRequest If the resource is contained in another resource, it SHALL NOT contain nested Resources contained.contained.empty()
dom-3 error ServiceRequest If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().as(canonical) | %resource.descendants().as(uri) | %resource.descendants().as(url))) or descendants().where(reference = '#').exists() or descendants().where(as(canonical) = '#').exists() or descendants().where(as(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4 error ServiceRequest If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5 error ServiceRequest If a resource is contained in another resource, it SHALL NOT have a security label contained.meta.security.empty()
dom-6 best practice ServiceRequest A resource should have narrative for robust management text.`div`.exists()
ele-1 error **ALL** elements All FHIR elements must have a @value or children hasValue() or (children().count() > id.count())
ext-1 error **ALL** extensions Must have either extensions or value[x], not both extension.exists() != value.exists()
prr-1 error ServiceRequest orderDetail SHALL only be present if code is present orderDetail.empty() or code.exists()

Key Elements View

NameFlagsCard.TypeDescription & Constraints    Filter: Filtersdoco
.. ServiceRequest C 0..* ServiceRequest A request for a service to be performed
Constraints: prr-1
... implicitRules ?!Σ 0..1 uri A set of rules under which this content was created
... modifierExtension ?! 0..* Extension Extensions that cannot be ignored
... status ?!SΣ 1..1 code Use #active for samples awaiting analysis, #completed for processed samples
Binding: RequestStatus (required): The status of a service order.
... doNotPerform ?!Σ 0..1 boolean True if service/procedure should not be performed
... code SΣ 1..1 CodeableConcept genomic_sample / epigenomic_sample — analysis type (BioSampleAnalysisTypeVS)
Binding: Biological Sample Analysis Type ValueSet (required)
... subject SΣ 1..1 Reference(Transplant Recipient) Transplant recipient who provided the sample
... encounter SΣ 0..1 Reference(Visit) Visit at which this sample was collected (navigable via specimen → BioSample extension)
... specimen SΣ 1..1 Reference(Biological Sample) The BioSample to be analysed

doco Documentation for this format

Terminology Bindings

Path Status Usage ValueSet Version Source
ServiceRequest.status Base required RequestStatus 📍4.0.1 FHIR Std.
ServiceRequest.intent Base required RequestIntent 📍4.0.1 FHIR Std.
ServiceRequest.code Base required Biological Sample Analysis Type ValueSet 📦0.1.0-ci-build This IG

Constraints

Id Grade Path(s) Description Expression
dom-2 error ServiceRequest If the resource is contained in another resource, it SHALL NOT contain nested Resources contained.contained.empty()
dom-3 error ServiceRequest If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().as(canonical) | %resource.descendants().as(uri) | %resource.descendants().as(url))) or descendants().where(reference = '#').exists() or descendants().where(as(canonical) = '#').exists() or descendants().where(as(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4 error ServiceRequest If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5 error ServiceRequest If a resource is contained in another resource, it SHALL NOT have a security label contained.meta.security.empty()
dom-6 best practice ServiceRequest A resource should have narrative for robust management text.`div`.exists()
ele-1 error **ALL** elements All FHIR elements must have a @value or children hasValue() or (children().count() > id.count())
ext-1 error **ALL** extensions Must have either extensions or value[x], not both extension.exists() != value.exists()
prr-1 error ServiceRequest orderDetail SHALL only be present if code is present orderDetail.empty() or code.exists()

Differential View

This structure is derived from ServiceRequest

NameFlagsCard.TypeDescription & Constraints    Filter: Filtersdoco
.. ServiceRequest 0..* ServiceRequest A request for a service to be performed
... status S 1..1 code Use #active for samples awaiting analysis, #completed for processed samples
... intent S 1..1 code Fixed to #order — each request is an analysis work order
Fixed Value: order
... code S 1..1 CodeableConcept genomic_sample / epigenomic_sample — analysis type (BioSampleAnalysisTypeVS)
Binding: Biological Sample Analysis Type ValueSet (required)
... encounter S 0..1 Reference(Visit) Visit at which this sample was collected (navigable via specimen → BioSample extension)
... specimen S 1..1 Reference(Biological Sample) The BioSample to be analysed

doco Documentation for this format

Terminology Bindings (Differential)

Path Status Usage ValueSet Version Source
ServiceRequest.code Base required Biological Sample Analysis Type ValueSet 📦0.1.0-ci-build This IG

Snapshot View

NameFlagsCard.TypeDescription & Constraints    Filter: Filtersdoco
.. ServiceRequest C 0..* ServiceRequest A request for a service to be performed
Constraints: prr-1
... id Σ 0..1 id Logical id of this artifact
... meta Σ 0..1 Meta Metadata about the resource
... implicitRules ?!Σ 0..1 uri A set of rules under which this content was created
... language 0..1 code Language of the resource content
Binding: CommonLanguages (preferred): A human language.
Additional BindingsPurpose
AllLanguages Max Binding
... text 0..1 Narrative Text summary of the resource, for human interpretation
This profile does not constrain the narrative in regard to content, language, or traceability to data elements
... contained 0..* Resource Contained, inline Resources
... extension 0..* Extension Additional content defined by implementations
... modifierExtension ?! 0..* Extension Extensions that cannot be ignored
... identifier Σ 0..* Identifier Identifiers assigned to this order
... instantiatesCanonical Σ 0..* canonical(ActivityDefinition | PlanDefinition) Instantiates FHIR protocol or definition
... instantiatesUri Σ 0..* uri Instantiates external protocol or definition
... basedOn Σ 0..* Reference(CarePlan | ServiceRequest | MedicationRequest) What request fulfills
... replaces Σ 0..* Reference(ServiceRequest) What request replaces
... requisition Σ 0..1 Identifier Composite Request ID
... status ?!SΣ 1..1 code Use #active for samples awaiting analysis, #completed for processed samples
Binding: RequestStatus (required): The status of a service order.
... intent ?!SΣ 1..1 code Fixed to #order — each request is an analysis work order
Binding: RequestIntent (required): The kind of service request.
Fixed Value: order
... category Σ 0..* CodeableConcept Classification of service
Binding: ServiceRequestCategoryCodes (example): Classification of the requested service.
... priority Σ 0..1 code routine | urgent | asap | stat
Binding: RequestPriority (required): Identifies the level of importance to be assigned to actioning the request.
... doNotPerform ?!Σ 0..1 boolean True if service/procedure should not be performed
... code SΣ 1..1 CodeableConcept genomic_sample / epigenomic_sample — analysis type (BioSampleAnalysisTypeVS)
Binding: Biological Sample Analysis Type ValueSet (required)
... orderDetail ΣC 0..* CodeableConcept Additional order information
Binding: ServiceRequestOrderDetailsCodes (example): Codified order entry details which are based on order context.
... quantity[x] Σ 0..1 Service amount
.... quantityQuantity Quantity
.... quantityRatio Ratio
.... quantityRange Range
... subject SΣ 1..1 Reference(Transplant Recipient) Transplant recipient who provided the sample
... encounter SΣ 0..1 Reference(Visit) Visit at which this sample was collected (navigable via specimen → BioSample extension)
... occurrence[x] Σ 0..1 When service should occur
.... occurrenceDateTime dateTime
.... occurrencePeriod Period
.... occurrenceTiming Timing
... asNeeded[x] Σ 0..1 Preconditions for service
Binding: SNOMEDCTMedicationAsNeededReasonCodes (example): A coded concept identifying the pre-condition that should hold prior to performing a procedure. For example "pain", "on flare-up", etc.
.... asNeededBoolean boolean
.... asNeededCodeableConcept CodeableConcept
... authoredOn Σ 0..1 dateTime Date request signed
... requester Σ 0..1 Reference(Practitioner | PractitionerRole | Organization | Patient | RelatedPerson | Device) Who/what is requesting service
... performerType Σ 0..1 CodeableConcept Performer role
Binding: ParticipantRoles (example): Indicates specific responsibility of an individual within the care team, such as "Primary physician", "Team coordinator", "Caregiver", etc.
... performer Σ 0..* Reference(Practitioner | PractitionerRole | Organization | CareTeam | HealthcareService | Patient | Device | RelatedPerson) Requested performer
... locationCode Σ 0..* CodeableConcept Requested location
Binding: V3 Value SetServiceDeliveryLocationRoleType (example): A location type where services are delivered.
... locationReference Σ 0..* Reference(Location) Requested location
... reasonCode Σ 0..* CodeableConcept Explanation/Justification for procedure or service
Binding: ProcedureReasonCodes (example): Diagnosis or problem codes justifying the reason for requesting the service investigation.
... reasonReference Σ 0..* Reference(Condition | Observation | DiagnosticReport | DocumentReference) Explanation/Justification for service or service
... insurance 0..* Reference(Coverage | ClaimResponse) Associated insurance coverage
... supportingInfo 0..* Reference(Resource) Additional clinical information
... specimen SΣ 1..1 Reference(Biological Sample) The BioSample to be analysed
... bodySite Σ 0..* CodeableConcept Location on Body
Binding: SNOMEDCTBodyStructures (example): Codes describing anatomical locations. May include laterality.
... note 0..* Annotation Comments
... patientInstruction Σ 0..1 string Patient or consumer-oriented instructions
... relevantHistory 0..* Reference(Provenance) Request provenance

doco Documentation for this format

Terminology Bindings

Path Status Usage ValueSet Version Source
ServiceRequest.language Base preferred Common Languages 📍4.0.1 FHIR Std.
ServiceRequest.status Base required RequestStatus 📍4.0.1 FHIR Std.
ServiceRequest.intent Base required RequestIntent 📍4.0.1 FHIR Std.
ServiceRequest.category Base example Service Request Category Codes 📍4.0.1 FHIR Std.
ServiceRequest.priority Base required Request priority 📍4.0.1 FHIR Std.
ServiceRequest.code Base required Biological Sample Analysis Type ValueSet 📦0.1.0-ci-build This IG
ServiceRequest.orderDetail Base example Service Request Order Details Codes 📍4.0.1 FHIR Std.
ServiceRequest.asNeeded[x] Base example SNOMED CT Medication As Needed Reason Codes 📍4.0.1 FHIR Std.
ServiceRequest.performerType Base example Participant Roles 📍4.0.1 FHIR Std.
ServiceRequest.locationCode Base example V3 Value SetServiceDeliveryLocationRoleType 📦2014-03-26 FHIR Std.
ServiceRequest.reasonCode Base example Procedure Reason Codes 📍4.0.1 FHIR Std.
ServiceRequest.bodySite Base example SNOMED CT Body Structures 📍4.0.1 FHIR Std.

Constraints

Id Grade Path(s) Description Expression
dom-2 error ServiceRequest If the resource is contained in another resource, it SHALL NOT contain nested Resources contained.contained.empty()
dom-3 error ServiceRequest If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().as(canonical) | %resource.descendants().as(uri) | %resource.descendants().as(url))) or descendants().where(reference = '#').exists() or descendants().where(as(canonical) = '#').exists() or descendants().where(as(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4 error ServiceRequest If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5 error ServiceRequest If a resource is contained in another resource, it SHALL NOT have a security label contained.meta.security.empty()
dom-6 best practice ServiceRequest A resource should have narrative for robust management text.`div`.exists()
ele-1 error **ALL** elements All FHIR elements must have a @value or children hasValue() or (children().count() > id.count())
ext-1 error **ALL** extensions Must have either extensions or value[x], not both extension.exists() != value.exists()
prr-1 error ServiceRequest orderDetail SHALL only be present if code is present orderDetail.empty() or code.exists()

 

Other representations of profile: CSV, Excel, Schematron