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PROTECT-CHILD Pediatric Transplant Data Implementation Guide
0.1.0-ci-build -

PROTECT-CHILD Pediatric Transplant Data Implementation Guide
0.1.0-ci-build - ci-build

PROTECT-CHILD Pediatric Transplant Data Implementation Guide, published by Protect Child. This guide is not an authorized publication; it is the continuous build for version 0.1.0-ci-build built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/hl7-eu/protect-child/ and changes regularly. See the Directory of published versions

: Clinical Event Type ValueSet - TTL Representation

Draft as of 2026-09-28

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@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

<http://hl7.org/fhir/ValueSet/clinical-event-type-vs> a fhir:ValueSet ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:Resource.id [ fhir:value "clinical-event-type-vs"] ;
  fhir:DomainResource.text [
     fhir:Narrative.status [ fhir:value "extensions" ] ;
     fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: ValueSet clinical-event-type-vs</b></p><a name=\"clinical-event-type-vs\"> </a><a name=\"hcclinical-event-type-vs\"> </a><p>This value set includes codes based on the following rules:</p><ul><li>Include these codes as defined in <a href=\"http://www.snomed.org/\"><code>http://snomed.info/sct</code></a><span title=\"Version is not explicitly stated. No matching Code System found\"> version Not Stated (use latest from terminology server)</span><table class=\"none\"><tr><td style=\"white-space:nowrap\"><b>Code</b></td><td><b>Display</b></td></tr><tr><td><a href=\"http://snomed.info/id/118926004\">118926004</a></td><td>Disorder of bile duct</td></tr><tr><td><a href=\"http://snomed.info/id/713886006\">713886006</a></td><td>BK virus nephropathy</td></tr><tr><td><a href=\"http://snomed.info/id/235886005\">235886005</a></td><td>Chronic hepatic failure</td></tr><tr><td><a href=\"http://snomed.info/id/432908002\">432908002</a></td><td>Chronic rejection of liver transplant</td></tr><tr><td><a href=\"http://snomed.info/id/90688005\">90688005</a></td><td>Chronic renal failure</td></tr><tr><td><a href=\"http://snomed.info/id/28944009\">28944009</a></td><td>Cytomegalovirus infection</td></tr><tr><td><a href=\"http://snomed.info/id/426136000\">426136000</a></td><td>Delayed renal graft function</td></tr><tr><td><a href=\"http://snomed.info/id/73211009\">73211009</a></td><td>Diabetes mellitus</td></tr><tr><td><a href=\"http://snomed.info/id/269295009\">269295009</a></td><td>Transplanted organ failure</td></tr><tr><td><a href=\"http://snomed.info/id/38341003\">38341003</a></td><td>Hypertensive disorder</td></tr><tr><td><a href=\"http://snomed.info/id/236569000\">236569000</a></td><td>Primary non-function of renal transplant</td></tr><tr><td><a href=\"http://snomed.info/id/236570004\">236570004</a></td><td>Renal transplant rejection</td></tr><tr><td><a href=\"http://snomed.info/id/235911006\">235911006</a></td><td>Liver transplant rejection</td></tr><tr><td><a href=\"http://snomed.info/id/126729006\">126729006</a></td><td>Thrombotic microangiopathy</td></tr><tr><td><a href=\"http://snomed.info/id/419620001\">419620001</a></td><td>Death</td></tr><tr><td><a href=\"http://snomed.info/id/450886002\">450886002</a></td><td>Posterior reversible encephalopathy syndrome</td></tr><tr><td><a href=\"http://snomed.info/id/254290004\">254290004</a></td><td>Lymphoproliferative disorder following transplantation</td></tr><tr><td><a href=\"http://snomed.info/id/363339009\">363339009</a></td><td>Urological system complication of procedure</td></tr><tr><td><a href=\"http://snomed.info/id/28104001\">28104001</a></td><td>Vascular complication of medical care</td></tr><tr><td><a href=\"http://snomed.info/id/14669001\">14669001</a></td><td>Acute kidney injury</td></tr></table></li><li>Include these codes as defined in <a href=\"CodeSystem-clinical-event-type-cs.html\"><code>https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/CodeSystem/clinical-event-type-cs</code></a><span title=\"Version is not explicitly stated, which means it is fixed to the version provided in this specification\"> version ?0.1.0-ci-build</span><table class=\"none\"><tr><td style=\"white-space:nowrap\"><b>Code</b></td><td><b>Display</b></td><td><b>Definition</b></td></tr><tr><td><a href=\"CodeSystem-clinical-event-type-cs.html#clinical-event-type-cs-alloimmunization\">alloimmunization</a></td><td style=\"color: #cccccc\">Alloimmunization</td><td>Development of antibodies against alloantigens (e.g. HLA) following transplantation or transfusion.</td></tr><tr><td><a href=\"CodeSystem-clinical-event-type-cs.html#clinical-event-type-cs-liver-early-allograft-dysfunction\">liver-early-allograft-dysfunction</a></td><td style=\"color: #cccccc\">Liver Early Allograft Dysfunction</td><td>Early dysfunction of the liver allograft in the initial post-transplant period.</td></tr><tr><td><a href=\"CodeSystem-clinical-event-type-cs.html#clinical-event-type-cs-liver-primary-non-function\">liver-primary-non-function</a></td><td style=\"color: #cccccc\">Liver Primary Non-Function</td><td>Liver allograft that never achieves function after transplantation, leading to urgent retransplantation or death.</td></tr><tr><td><a href=\"CodeSystem-clinical-event-type-cs.html#clinical-event-type-cs-mtor-inhibitors-toxicity\">mtor-inhibitors-toxicity</a></td><td style=\"color: #cccccc\">mTOR Inhibitors Toxicity</td><td>Adverse effects attributable to mTOR-inhibitor immunosuppression.</td></tr><tr><td><a href=\"CodeSystem-clinical-event-type-cs.html#clinical-event-type-cs-mycophenolate-toxicity\">mycophenolate-toxicity</a></td><td style=\"color: #cccccc\">Mycophenolate Toxicity</td><td>Adverse effects attributable to mycophenolate immunosuppression.</td></tr><tr><td><a href=\"CodeSystem-clinical-event-type-cs.html#clinical-event-type-cs-relapse-primary-immunomediated-disease\">relapse-primary-immunomediated-disease</a></td><td style=\"color: #cccccc\">Relapse Primary Immunomediated Disease</td><td>Recurrence of the primary immune-mediated disease that led to transplantation.</td></tr><tr><td><a href=\"CodeSystem-clinical-event-type-cs.html#clinical-event-type-cs-renal-cni-toxicity\">renal-cni-toxicity</a></td><td style=\"color: #cccccc\">Renal CNI Toxicity</td><td>Calcineurin-inhibitor-induced renal toxicity.</td></tr><tr><td><a href=\"CodeSystem-clinical-event-type-cs.html#clinical-event-type-cs-histologic-evidence-cni-toxicity\">histologic-evidence-cni-toxicity</a></td><td style=\"color: #cccccc\">Histological evidence of CNI nephrotoxicity</td><td>Histological findings consistent with calcineurin-inhibitor nephrotoxicity.</td></tr><tr><td><a href=\"CodeSystem-clinical-event-type-cs.html#clinical-event-type-cs-hypoxic-ischemic-event-pltx\">hypoxic-ischemic-event-pltx</a></td><td style=\"color: #cccccc\">Hypoxic-ischemic event post liver transplant</td><td>Hypoxic-ischemic event occurring after paediatric liver transplantation (Liver/combined).</td></tr></table></li></ul></div>"
  ] ;
  fhir:ValueSet.url [ fhir:value "https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/ValueSet/clinical-event-type-vs"] ;
  fhir:ValueSet.version [ fhir:value "0.1.0-ci-build"] ;
  fhir:ValueSet.name [ fhir:value "ClinicalEventTypeVS"] ;
  fhir:ValueSet.title [ fhir:value "Clinical Event Type ValueSet"] ;
  fhir:ValueSet.status [ fhir:value "draft"] ;
  fhir:ValueSet.experimental [ fhir:value "true"^^xsd:boolean] ;
  fhir:ValueSet.date [ fhir:value "2026-09-28T06:51:47+00:00"^^xsd:dateTime] ;
  fhir:ValueSet.publisher [ fhir:value "Protect Child"] ;
  fhir:ValueSet.contact [
     fhir:index 0 ;
     fhir:ContactDetail.name [ fhir:value "Protect Child" ] ;
     fhir:ContactDetail.telecom [
       fhir:index 0 ;
       fhir:ContactPoint.system [ fhir:value "url" ] ;
       fhir:ContactPoint.value [ fhir:value "https://protect-child.eu/" ]
     ]
  ] ;
  fhir:ValueSet.description [ fhir:value "Allowed clinical event types in the PROTECT-CHILD study (DMv1.2)."] ;
  fhir:ValueSet.compose [
     fhir:ValueSet.compose.include [
       fhir:index 0 ;
       fhir:ValueSet.compose.include.system [ fhir:value "http://snomed.info/sct" ] ;
       fhir:ValueSet.compose.include.concept [
         fhir:index 0 ;
         fhir:ValueSet.compose.include.concept.code [ fhir:value "118926004" ] ;
         fhir:ValueSet.compose.include.concept.display [ fhir:value "Disorder of bile duct" ]
       ], [
         fhir:index 1 ;
         fhir:ValueSet.compose.include.concept.code [ fhir:value "713886006" ] ;
         fhir:ValueSet.compose.include.concept.display [ fhir:value "BK virus nephropathy" ]
       ], [
         fhir:index 2 ;
         fhir:ValueSet.compose.include.concept.code [ fhir:value "235886005" ] ;
         fhir:ValueSet.compose.include.concept.display [ fhir:value "Chronic hepatic failure" ]
       ], [
         fhir:index 3 ;
         fhir:ValueSet.compose.include.concept.code [ fhir:value "432908002" ] ;
         fhir:ValueSet.compose.include.concept.display [ fhir:value "Chronic rejection of liver transplant" ]
       ], [
         fhir:index 4 ;
         fhir:ValueSet.compose.include.concept.code [ fhir:value "90688005" ] ;
         fhir:ValueSet.compose.include.concept.display [ fhir:value "Chronic renal failure" ]
       ], [
         fhir:index 5 ;
         fhir:ValueSet.compose.include.concept.code [ fhir:value "28944009" ] ;
         fhir:ValueSet.compose.include.concept.display [ fhir:value "Cytomegalovirus infection" ]
       ], [
         fhir:index 6 ;
         fhir:ValueSet.compose.include.concept.code [ fhir:value "426136000" ] ;
         fhir:ValueSet.compose.include.concept.display [ fhir:value "Delayed renal graft function" ]
       ], [
         fhir:index 7 ;
         fhir:ValueSet.compose.include.concept.code [ fhir:value "73211009" ] ;
         fhir:ValueSet.compose.include.concept.display [ fhir:value "Diabetes mellitus" ]
       ], [
         fhir:index 8 ;
         fhir:ValueSet.compose.include.concept.code [ fhir:value "269295009" ] ;
         fhir:ValueSet.compose.include.concept.display [ fhir:value "Transplanted organ failure" ]
       ], [
         fhir:index 9 ;
         fhir:ValueSet.compose.include.concept.code [ fhir:value "38341003" ] ;
         fhir:ValueSet.compose.include.concept.display [ fhir:value "Hypertensive disorder" ]
       ], [
         fhir:index 10 ;
         fhir:ValueSet.compose.include.concept.code [ fhir:value "236569000" ] ;
         fhir:ValueSet.compose.include.concept.display [ fhir:value "Primary non-function of renal transplant" ]
       ], [
         fhir:index 11 ;
         fhir:ValueSet.compose.include.concept.code [ fhir:value "236570004" ] ;
         fhir:ValueSet.compose.include.concept.display [ fhir:value "Renal transplant rejection" ]
       ], [
         fhir:index 12 ;
         fhir:ValueSet.compose.include.concept.code [ fhir:value "235911006" ] ;
         fhir:ValueSet.compose.include.concept.display [ fhir:value "Liver transplant rejection" ]
       ], [
         fhir:index 13 ;
         fhir:ValueSet.compose.include.concept.code [ fhir:value "126729006" ] ;
         fhir:ValueSet.compose.include.concept.display [ fhir:value "Thrombotic microangiopathy" ]
       ], [
         fhir:index 14 ;
         fhir:ValueSet.compose.include.concept.code [ fhir:value "419620001" ] ;
         fhir:ValueSet.compose.include.concept.display [ fhir:value "Death" ]
       ], [
         fhir:index 15 ;
         fhir:ValueSet.compose.include.concept.code [ fhir:value "450886002" ] ;
         fhir:ValueSet.compose.include.concept.display [ fhir:value "Posterior reversible encephalopathy syndrome" ]
       ], [
         fhir:index 16 ;
         fhir:ValueSet.compose.include.concept.code [ fhir:value "254290004" ] ;
         fhir:ValueSet.compose.include.concept.display [ fhir:value "Lymphoproliferative disorder following transplantation" ]
       ], [
         fhir:index 17 ;
         fhir:ValueSet.compose.include.concept.code [ fhir:value "363339009" ] ;
         fhir:ValueSet.compose.include.concept.display [ fhir:value "Urological system complication of procedure" ]
       ], [
         fhir:index 18 ;
         fhir:ValueSet.compose.include.concept.code [ fhir:value "28104001" ] ;
         fhir:ValueSet.compose.include.concept.display [ fhir:value "Vascular complication of medical care" ]
       ], [
         fhir:index 19 ;
         fhir:ValueSet.compose.include.concept.code [ fhir:value "14669001" ] ;
         fhir:ValueSet.compose.include.concept.display [ fhir:value "Acute kidney injury" ]
       ]
     ], [
       fhir:index 1 ;
       fhir:ValueSet.compose.include.system [ fhir:value "https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/CodeSystem/clinical-event-type-cs" ] ;
       fhir:ValueSet.compose.include.concept [
         fhir:index 0 ;
         fhir:ValueSet.compose.include.concept.code [ fhir:value "alloimmunization" ]
       ], [
         fhir:index 1 ;
         fhir:ValueSet.compose.include.concept.code [ fhir:value "liver-early-allograft-dysfunction" ]
       ], [
         fhir:index 2 ;
         fhir:ValueSet.compose.include.concept.code [ fhir:value "liver-primary-non-function" ]
       ], [
         fhir:index 3 ;
         fhir:ValueSet.compose.include.concept.code [ fhir:value "mtor-inhibitors-toxicity" ]
       ], [
         fhir:index 4 ;
         fhir:ValueSet.compose.include.concept.code [ fhir:value "mycophenolate-toxicity" ]
       ], [
         fhir:index 5 ;
         fhir:ValueSet.compose.include.concept.code [ fhir:value "relapse-primary-immunomediated-disease" ]
       ], [
         fhir:index 6 ;
         fhir:ValueSet.compose.include.concept.code [ fhir:value "renal-cni-toxicity" ]
       ], [
         fhir:index 7 ;
         fhir:ValueSet.compose.include.concept.code [ fhir:value "histologic-evidence-cni-toxicity" ]
       ], [
         fhir:index 8 ;
         fhir:ValueSet.compose.include.concept.code [ fhir:value "hypoxic-ischemic-event-pltx" ]
       ]
     ]
  ] .

# - ontology header ------------------------------------------------------------

<http://hl7.org/fhir/ValueSet/clinical-event-type-vs.ttl> a owl:Ontology ;
  owl:imports fhir:fhir.ttl ;
  owl:versionIRI <http://build.fhir.org/ValueSet/clinical-event-type-vs.ttl> .