Clinical Event Type CodeSystem - TTL Representation - PROTECT-CHILD Pediatric Transplant Data Implementation Guide v0.1.0-ci-build

PROTECT-CHILD Pediatric Transplant Data Implementation Guide, published by Protect Child. This guide is not an authorized publication; it is the continuous build for version 0.1.0-ci-build built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/hl7-eu/protect-child/ and changes regularly. See the Directory of published versions
: Clinical Event Type CodeSystem - TTL Representation

Draft as of 2026-08-11
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@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

<http://hl7.org/fhir/CodeSystem/clinical-event-type-cs> a fhir:CodeSystem ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:Resource.id [ fhir:value "clinical-event-type-cs"] ;
  fhir:DomainResource.text [
     fhir:Narrative.status [ fhir:value "generated" ] ;
     fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: CodeSystem clinical-event-type-cs</b></p><a name=\"clinical-event-type-cs\"> </a><a name=\"hcclinical-event-type-cs\"> </a><p>This case-insensitive code system <code>https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/CodeSystem/clinical-event-type-cs</code> defines the following codes:</p><table class=\"codes\"><tr><td style=\"white-space:nowrap\"><b>Code</b></td><td><b>Display</b></td><td><b>Definition</b></td></tr><tr><td style=\"white-space:nowrap\">alloimmunization<a name=\"clinical-event-type-cs-alloimmunization\"> </a></td><td>Alloimmunization</td><td>Development of antibodies against alloantigens (e.g. HLA) following transplantation or transfusion.</td></tr><tr><td style=\"white-space:nowrap\">biliary-complications<a name=\"clinical-event-type-cs-biliary-complications\"> </a></td><td>Biliary Complications</td><td>Post-transplant complications of the biliary tract (e.g. stricture, leak, stones).</td></tr><tr><td style=\"white-space:nowrap\">bk-virus-infection<a name=\"clinical-event-type-cs-bk-virus-infection\"> </a></td><td>BK Virus Infection</td><td>Infection or reactivation of BK polyomavirus.</td></tr><tr><td style=\"white-space:nowrap\">chronic-liver-failure<a name=\"clinical-event-type-cs-chronic-liver-failure\"> </a></td><td>Chronic Liver Failure</td><td>Progressive, long-standing loss of liver function.</td></tr><tr><td style=\"white-space:nowrap\">chronic-liver-rejection<a name=\"clinical-event-type-cs-chronic-liver-rejection\"> </a></td><td>Chronic Liver Rejection</td><td>Chronic rejection of the liver allograft (e.g. ductopenia / vanishing bile duct syndrome).</td></tr><tr><td style=\"white-space:nowrap\">chronic-renal-failure-after-pltx<a name=\"clinical-event-type-cs-chronic-renal-failure-after-pltx\"> </a></td><td>Chronic Renal Failure After pLTx</td><td>Chronic kidney disease developing after paediatric liver transplantation.</td></tr><tr><td style=\"white-space:nowrap\">cmv-infection<a name=\"clinical-event-type-cs-cmv-infection\"> </a></td><td>Cytomegalovirus Infection</td><td>Infection or reactivation of cytomegalovirus.</td></tr><tr><td style=\"white-space:nowrap\">delayed-kidney-graft-function<a name=\"clinical-event-type-cs-delayed-kidney-graft-function\"> </a></td><td>Delayed Kidney Graft Function</td><td>Delayed function of the kidney allograft requiring dialysis in the first post-transplant week.</td></tr><tr><td style=\"white-space:nowrap\">diabetes<a name=\"clinical-event-type-cs-diabetes\"> </a></td><td>Diabetes</td><td>Diabetes mellitus, including new-onset diabetes after transplantation.</td></tr><tr><td style=\"white-space:nowrap\">graft-failure<a name=\"clinical-event-type-cs-graft-failure\"> </a></td><td>Graft Failure</td><td>Loss of function of the transplanted organ.</td></tr><tr><td style=\"white-space:nowrap\">high-blood-pressure<a name=\"clinical-event-type-cs-high-blood-pressure\"> </a></td><td>High Blood Pressure</td><td>Arterial hypertension.</td></tr><tr><td style=\"white-space:nowrap\">kidney-primary-non-function<a name=\"clinical-event-type-cs-kidney-primary-non-function\"> </a></td><td>Kidney Primary Non-Function</td><td>Kidney allograft that never achieves function after transplantation.</td></tr><tr><td style=\"white-space:nowrap\">kidney-rejection-episode<a name=\"clinical-event-type-cs-kidney-rejection-episode\"> </a></td><td>Kidney Rejection Episode</td><td>An episode of acute or chronic rejection of the kidney allograft.</td></tr><tr><td style=\"white-space:nowrap\">liver-early-allograft-dysfunction<a name=\"clinical-event-type-cs-liver-early-allograft-dysfunction\"> </a></td><td>Liver Early Allograft Dysfunction</td><td>Early dysfunction of the liver allograft in the initial post-transplant period.</td></tr><tr><td style=\"white-space:nowrap\">liver-primary-non-function<a name=\"clinical-event-type-cs-liver-primary-non-function\"> </a></td><td>Liver Primary Non-Function</td><td>Liver allograft that never achieves function, requiring urgent re-transplantation.</td></tr><tr><td style=\"white-space:nowrap\">liver-rejection-episode<a name=\"clinical-event-type-cs-liver-rejection-episode\"> </a></td><td>Liver Rejection Episode</td><td>An episode of acute or chronic rejection of the liver allograft.</td></tr><tr><td style=\"white-space:nowrap\">microangiopathy<a name=\"clinical-event-type-cs-microangiopathy\"> </a></td><td>Microangiopathy</td><td>Thrombotic microangiopathy affecting small blood vessels.</td></tr><tr><td style=\"white-space:nowrap\">mortality<a name=\"clinical-event-type-cs-mortality\"> </a></td><td>Mortality</td><td>Death of the patient.</td></tr><tr><td style=\"white-space:nowrap\">mtor-inhibitors-toxicity<a name=\"clinical-event-type-cs-mtor-inhibitors-toxicity\"> </a></td><td>mTOR Inhibitors Toxicity</td><td>Adverse effects attributable to mTOR-inhibitor immunosuppression.</td></tr><tr><td style=\"white-space:nowrap\">mycophenolate-toxicity<a name=\"clinical-event-type-cs-mycophenolate-toxicity\"> </a></td><td>Mycophenolate Toxicity</td><td>Adverse effects attributable to mycophenolate immunosuppression.</td></tr><tr><td style=\"white-space:nowrap\">pres<a name=\"clinical-event-type-cs-pres\"> </a></td><td>PRES</td><td>Posterior reversible encephalopathy syndrome (PRES).</td></tr><tr><td style=\"white-space:nowrap\">ptld<a name=\"clinical-event-type-cs-ptld\"> </a></td><td>PTLD</td><td>Post-transplant lymphoproliferative disorder (PTLD).</td></tr><tr><td style=\"white-space:nowrap\">relapse-primary-immunomediated-disease<a name=\"clinical-event-type-cs-relapse-primary-immunomediated-disease\"> </a></td><td>Relapse Primary Immunomediated Disease</td><td>Recurrence of the primary immune-mediated disease that led to transplantation.</td></tr><tr><td style=\"white-space:nowrap\">renal-cni-toxicity<a name=\"clinical-event-type-cs-renal-cni-toxicity\"> </a></td><td>Renal CNI Toxicity</td><td>Calcineurin-inhibitor-induced renal toxicity.</td></tr><tr><td style=\"white-space:nowrap\">urological-complications<a name=\"clinical-event-type-cs-urological-complications\"> </a></td><td>Urological Complications</td><td>Post-transplant complications of the urinary tract (e.g. obstruction, leak, reflux).</td></tr><tr><td style=\"white-space:nowrap\">vascular-complications<a name=\"clinical-event-type-cs-vascular-complications\"> </a></td><td>Vascular Complications</td><td>Post-transplant vascular complications (e.g. thrombosis, stenosis).</td></tr></table></div>"
  ] ;
  fhir:CodeSystem.url [ fhir:value "https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/CodeSystem/clinical-event-type-cs"] ;
  fhir:CodeSystem.version [ fhir:value "0.1.0-ci-build"] ;
  fhir:CodeSystem.name [ fhir:value "ClinicalEventTypeCS"] ;
  fhir:CodeSystem.title [ fhir:value "Clinical Event Type CodeSystem"] ;
  fhir:CodeSystem.status [ fhir:value "draft"] ;
  fhir:CodeSystem.experimental [ fhir:value "true"^^xsd:boolean] ;
  fhir:CodeSystem.date [ fhir:value "2026-08-11T12:50:29+00:00"^^xsd:dateTime] ;
  fhir:CodeSystem.publisher [ fhir:value "Protect Child"] ;
  fhir:CodeSystem.contact [
     fhir:index 0 ;
     fhir:ContactDetail.name [ fhir:value "Protect Child" ] ;
     fhir:ContactDetail.telecom [
       fhir:index 0 ;
       fhir:ContactPoint.system [ fhir:value "url" ] ;
       fhir:ContactPoint.value [ fhir:value "https://protect-child.eu/" ]
     ]
  ] ;
  fhir:CodeSystem.description [ fhir:value "Types of clinical events in the PROTECT-CHILD study (DMv1.2), replacing outcome_type and post_event_type."] ;
  fhir:CodeSystem.caseSensitive [ fhir:value "false"^^xsd:boolean] ;
  fhir:CodeSystem.content [ fhir:value "complete"] ;
  fhir:CodeSystem.count [ fhir:value "26"^^xsd:nonNegativeInteger] ;
  fhir:CodeSystem.concept [
     fhir:index 0 ;
     fhir:CodeSystem.concept.code [ fhir:value "alloimmunization" ] ;
     fhir:CodeSystem.concept.display [ fhir:value "Alloimmunization" ] ;
     fhir:CodeSystem.concept.definition [ fhir:value "Development of antibodies against alloantigens (e.g. HLA) following transplantation or transfusion." ]
  ], [
     fhir:index 1 ;
     fhir:CodeSystem.concept.code [ fhir:value "biliary-complications" ] ;
     fhir:CodeSystem.concept.display [ fhir:value "Biliary Complications" ] ;
     fhir:CodeSystem.concept.definition [ fhir:value "Post-transplant complications of the biliary tract (e.g. stricture, leak, stones)." ]
  ], [
     fhir:index 2 ;
     fhir:CodeSystem.concept.code [ fhir:value "bk-virus-infection" ] ;
     fhir:CodeSystem.concept.display [ fhir:value "BK Virus Infection" ] ;
     fhir:CodeSystem.concept.definition [ fhir:value "Infection or reactivation of BK polyomavirus." ]
  ], [
     fhir:index 3 ;
     fhir:CodeSystem.concept.code [ fhir:value "chronic-liver-failure" ] ;
     fhir:CodeSystem.concept.display [ fhir:value "Chronic Liver Failure" ] ;
     fhir:CodeSystem.concept.definition [ fhir:value "Progressive, long-standing loss of liver function." ]
  ], [
     fhir:index 4 ;
     fhir:CodeSystem.concept.code [ fhir:value "chronic-liver-rejection" ] ;
     fhir:CodeSystem.concept.display [ fhir:value "Chronic Liver Rejection" ] ;
     fhir:CodeSystem.concept.definition [ fhir:value "Chronic rejection of the liver allograft (e.g. ductopenia / vanishing bile duct syndrome)." ]
  ], [
     fhir:index 5 ;
     fhir:CodeSystem.concept.code [ fhir:value "chronic-renal-failure-after-pltx" ] ;
     fhir:CodeSystem.concept.display [ fhir:value "Chronic Renal Failure After pLTx" ] ;
     fhir:CodeSystem.concept.definition [ fhir:value "Chronic kidney disease developing after paediatric liver transplantation." ]
  ], [
     fhir:index 6 ;
     fhir:CodeSystem.concept.code [ fhir:value "cmv-infection" ] ;
     fhir:CodeSystem.concept.display [ fhir:value "Cytomegalovirus Infection" ] ;
     fhir:CodeSystem.concept.definition [ fhir:value "Infection or reactivation of cytomegalovirus." ]
  ], [
     fhir:index 7 ;
     fhir:CodeSystem.concept.code [ fhir:value "delayed-kidney-graft-function" ] ;
     fhir:CodeSystem.concept.display [ fhir:value "Delayed Kidney Graft Function" ] ;
     fhir:CodeSystem.concept.definition [ fhir:value "Delayed function of the kidney allograft requiring dialysis in the first post-transplant week." ]
  ], [
     fhir:index 8 ;
     fhir:CodeSystem.concept.code [ fhir:value "diabetes" ] ;
     fhir:CodeSystem.concept.display [ fhir:value "Diabetes" ] ;
     fhir:CodeSystem.concept.definition [ fhir:value "Diabetes mellitus, including new-onset diabetes after transplantation." ]
  ], [
     fhir:index 9 ;
     fhir:CodeSystem.concept.code [ fhir:value "graft-failure" ] ;
     fhir:CodeSystem.concept.display [ fhir:value "Graft Failure" ] ;
     fhir:CodeSystem.concept.definition [ fhir:value "Loss of function of the transplanted organ." ]
  ], [
     fhir:index 10 ;
     fhir:CodeSystem.concept.code [ fhir:value "high-blood-pressure" ] ;
     fhir:CodeSystem.concept.display [ fhir:value "High Blood Pressure" ] ;
     fhir:CodeSystem.concept.definition [ fhir:value "Arterial hypertension." ]
  ], [
     fhir:index 11 ;
     fhir:CodeSystem.concept.code [ fhir:value "kidney-primary-non-function" ] ;
     fhir:CodeSystem.concept.display [ fhir:value "Kidney Primary Non-Function" ] ;
     fhir:CodeSystem.concept.definition [ fhir:value "Kidney allograft that never achieves function after transplantation." ]
  ], [
     fhir:index 12 ;
     fhir:CodeSystem.concept.code [ fhir:value "kidney-rejection-episode" ] ;
     fhir:CodeSystem.concept.display [ fhir:value "Kidney Rejection Episode" ] ;
     fhir:CodeSystem.concept.definition [ fhir:value "An episode of acute or chronic rejection of the kidney allograft." ]
  ], [
     fhir:index 13 ;
     fhir:CodeSystem.concept.code [ fhir:value "liver-early-allograft-dysfunction" ] ;
     fhir:CodeSystem.concept.display [ fhir:value "Liver Early Allograft Dysfunction" ] ;
     fhir:CodeSystem.concept.definition [ fhir:value "Early dysfunction of the liver allograft in the initial post-transplant period." ]
  ], [
     fhir:index 14 ;
     fhir:CodeSystem.concept.code [ fhir:value "liver-primary-non-function" ] ;
     fhir:CodeSystem.concept.display [ fhir:value "Liver Primary Non-Function" ] ;
     fhir:CodeSystem.concept.definition [ fhir:value "Liver allograft that never achieves function, requiring urgent re-transplantation." ]
  ], [
     fhir:index 15 ;
     fhir:CodeSystem.concept.code [ fhir:value "liver-rejection-episode" ] ;
     fhir:CodeSystem.concept.display [ fhir:value "Liver Rejection Episode" ] ;
     fhir:CodeSystem.concept.definition [ fhir:value "An episode of acute or chronic rejection of the liver allograft." ]
  ], [
     fhir:index 16 ;
     fhir:CodeSystem.concept.code [ fhir:value "microangiopathy" ] ;
     fhir:CodeSystem.concept.display [ fhir:value "Microangiopathy" ] ;
     fhir:CodeSystem.concept.definition [ fhir:value "Thrombotic microangiopathy affecting small blood vessels." ]
  ], [
     fhir:index 17 ;
     fhir:CodeSystem.concept.code [ fhir:value "mortality" ] ;
     fhir:CodeSystem.concept.display [ fhir:value "Mortality" ] ;
     fhir:CodeSystem.concept.definition [ fhir:value "Death of the patient." ]
  ], [
     fhir:index 18 ;
     fhir:CodeSystem.concept.code [ fhir:value "mtor-inhibitors-toxicity" ] ;
     fhir:CodeSystem.concept.display [ fhir:value "mTOR Inhibitors Toxicity" ] ;
     fhir:CodeSystem.concept.definition [ fhir:value "Adverse effects attributable to mTOR-inhibitor immunosuppression." ]
  ], [
     fhir:index 19 ;
     fhir:CodeSystem.concept.code [ fhir:value "mycophenolate-toxicity" ] ;
     fhir:CodeSystem.concept.display [ fhir:value "Mycophenolate Toxicity" ] ;
     fhir:CodeSystem.concept.definition [ fhir:value "Adverse effects attributable to mycophenolate immunosuppression." ]
  ], [
     fhir:index 20 ;
     fhir:CodeSystem.concept.code [ fhir:value "pres" ] ;
     fhir:CodeSystem.concept.display [ fhir:value "PRES" ] ;
     fhir:CodeSystem.concept.definition [ fhir:value "Posterior reversible encephalopathy syndrome (PRES)." ]
  ], [
     fhir:index 21 ;
     fhir:CodeSystem.concept.code [ fhir:value "ptld" ] ;
     fhir:CodeSystem.concept.display [ fhir:value "PTLD" ] ;
     fhir:CodeSystem.concept.definition [ fhir:value "Post-transplant lymphoproliferative disorder (PTLD)." ]
  ], [
     fhir:index 22 ;
     fhir:CodeSystem.concept.code [ fhir:value "relapse-primary-immunomediated-disease" ] ;
     fhir:CodeSystem.concept.display [ fhir:value "Relapse Primary Immunomediated Disease" ] ;
     fhir:CodeSystem.concept.definition [ fhir:value "Recurrence of the primary immune-mediated disease that led to transplantation." ]
  ], [
     fhir:index 23 ;
     fhir:CodeSystem.concept.code [ fhir:value "renal-cni-toxicity" ] ;
     fhir:CodeSystem.concept.display [ fhir:value "Renal CNI Toxicity" ] ;
     fhir:CodeSystem.concept.definition [ fhir:value "Calcineurin-inhibitor-induced renal toxicity." ]
  ], [
     fhir:index 24 ;
     fhir:CodeSystem.concept.code [ fhir:value "urological-complications" ] ;
     fhir:CodeSystem.concept.display [ fhir:value "Urological Complications" ] ;
     fhir:CodeSystem.concept.definition [ fhir:value "Post-transplant complications of the urinary tract (e.g. obstruction, leak, reflux)." ]
  ], [
     fhir:index 25 ;
     fhir:CodeSystem.concept.code [ fhir:value "vascular-complications" ] ;
     fhir:CodeSystem.concept.display [ fhir:value "Vascular Complications" ] ;
     fhir:CodeSystem.concept.definition [ fhir:value "Post-transplant vascular complications (e.g. thrombosis, stenosis)." ]
  ] .

# - ontology header ------------------------------------------------------------

<http://hl7.org/fhir/CodeSystem/clinical-event-type-cs.ttl> a owl:Ontology ;
  owl:imports fhir:fhir.ttl ;
  owl:versionIRI <http://build.fhir.org/CodeSystem/clinical-event-type-cs.ttl> .