PROTECT-CHILD Pediatric Transplant Data Implementation Guide
0.1.0-ci-build -
PROTECT-CHILD Pediatric Transplant Data Implementation Guide
0.1.0-ci-build - ci-build
PROTECT-CHILD Pediatric Transplant Data Implementation Guide
0.1.0-ci-build - ci-build
PROTECT-CHILD Pediatric Transplant Data Implementation Guide, published by Protect Child. This guide is not an authorized publication; it is the continuous build for version 0.1.0-ci-build built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/hl7-eu/protect-child/ and changes regularly. See the Directory of published versions
| Draft as of 2026-08-11 |
{
"resourceType" : "CodeSystem",
"id" : "clinical-event-type-cs",
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: CodeSystem clinical-event-type-cs</b></p><a name=\"clinical-event-type-cs\"> </a><a name=\"hcclinical-event-type-cs\"> </a><p>This case-insensitive code system <code>https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/CodeSystem/clinical-event-type-cs</code> defines the following codes:</p><table class=\"codes\"><tr><td style=\"white-space:nowrap\"><b>Code</b></td><td><b>Display</b></td><td><b>Definition</b></td></tr><tr><td style=\"white-space:nowrap\">alloimmunization<a name=\"clinical-event-type-cs-alloimmunization\"> </a></td><td>Alloimmunization</td><td>Development of antibodies against alloantigens (e.g. HLA) following transplantation or transfusion.</td></tr><tr><td style=\"white-space:nowrap\">biliary-complications<a name=\"clinical-event-type-cs-biliary-complications\"> </a></td><td>Biliary Complications</td><td>Post-transplant complications of the biliary tract (e.g. stricture, leak, stones).</td></tr><tr><td style=\"white-space:nowrap\">bk-virus-infection<a name=\"clinical-event-type-cs-bk-virus-infection\"> </a></td><td>BK Virus Infection</td><td>Infection or reactivation of BK polyomavirus.</td></tr><tr><td style=\"white-space:nowrap\">chronic-liver-failure<a name=\"clinical-event-type-cs-chronic-liver-failure\"> </a></td><td>Chronic Liver Failure</td><td>Progressive, long-standing loss of liver function.</td></tr><tr><td style=\"white-space:nowrap\">chronic-liver-rejection<a name=\"clinical-event-type-cs-chronic-liver-rejection\"> </a></td><td>Chronic Liver Rejection</td><td>Chronic rejection of the liver allograft (e.g. ductopenia / vanishing bile duct syndrome).</td></tr><tr><td style=\"white-space:nowrap\">chronic-renal-failure-after-pltx<a name=\"clinical-event-type-cs-chronic-renal-failure-after-pltx\"> </a></td><td>Chronic Renal Failure After pLTx</td><td>Chronic kidney disease developing after paediatric liver transplantation.</td></tr><tr><td style=\"white-space:nowrap\">cmv-infection<a name=\"clinical-event-type-cs-cmv-infection\"> </a></td><td>Cytomegalovirus Infection</td><td>Infection or reactivation of cytomegalovirus.</td></tr><tr><td style=\"white-space:nowrap\">delayed-kidney-graft-function<a name=\"clinical-event-type-cs-delayed-kidney-graft-function\"> </a></td><td>Delayed Kidney Graft Function</td><td>Delayed function of the kidney allograft requiring dialysis in the first post-transplant week.</td></tr><tr><td style=\"white-space:nowrap\">diabetes<a name=\"clinical-event-type-cs-diabetes\"> </a></td><td>Diabetes</td><td>Diabetes mellitus, including new-onset diabetes after transplantation.</td></tr><tr><td style=\"white-space:nowrap\">graft-failure<a name=\"clinical-event-type-cs-graft-failure\"> </a></td><td>Graft Failure</td><td>Loss of function of the transplanted organ.</td></tr><tr><td style=\"white-space:nowrap\">high-blood-pressure<a name=\"clinical-event-type-cs-high-blood-pressure\"> </a></td><td>High Blood Pressure</td><td>Arterial hypertension.</td></tr><tr><td style=\"white-space:nowrap\">kidney-primary-non-function<a name=\"clinical-event-type-cs-kidney-primary-non-function\"> </a></td><td>Kidney Primary Non-Function</td><td>Kidney allograft that never achieves function after transplantation.</td></tr><tr><td style=\"white-space:nowrap\">kidney-rejection-episode<a name=\"clinical-event-type-cs-kidney-rejection-episode\"> </a></td><td>Kidney Rejection Episode</td><td>An episode of acute or chronic rejection of the kidney allograft.</td></tr><tr><td style=\"white-space:nowrap\">liver-early-allograft-dysfunction<a name=\"clinical-event-type-cs-liver-early-allograft-dysfunction\"> </a></td><td>Liver Early Allograft Dysfunction</td><td>Early dysfunction of the liver allograft in the initial post-transplant period.</td></tr><tr><td style=\"white-space:nowrap\">liver-primary-non-function<a name=\"clinical-event-type-cs-liver-primary-non-function\"> </a></td><td>Liver Primary Non-Function</td><td>Liver allograft that never achieves function, requiring urgent re-transplantation.</td></tr><tr><td style=\"white-space:nowrap\">liver-rejection-episode<a name=\"clinical-event-type-cs-liver-rejection-episode\"> </a></td><td>Liver Rejection Episode</td><td>An episode of acute or chronic rejection of the liver allograft.</td></tr><tr><td style=\"white-space:nowrap\">microangiopathy<a name=\"clinical-event-type-cs-microangiopathy\"> </a></td><td>Microangiopathy</td><td>Thrombotic microangiopathy affecting small blood vessels.</td></tr><tr><td style=\"white-space:nowrap\">mortality<a name=\"clinical-event-type-cs-mortality\"> </a></td><td>Mortality</td><td>Death of the patient.</td></tr><tr><td style=\"white-space:nowrap\">mtor-inhibitors-toxicity<a name=\"clinical-event-type-cs-mtor-inhibitors-toxicity\"> </a></td><td>mTOR Inhibitors Toxicity</td><td>Adverse effects attributable to mTOR-inhibitor immunosuppression.</td></tr><tr><td style=\"white-space:nowrap\">mycophenolate-toxicity<a name=\"clinical-event-type-cs-mycophenolate-toxicity\"> </a></td><td>Mycophenolate Toxicity</td><td>Adverse effects attributable to mycophenolate immunosuppression.</td></tr><tr><td style=\"white-space:nowrap\">pres<a name=\"clinical-event-type-cs-pres\"> </a></td><td>PRES</td><td>Posterior reversible encephalopathy syndrome (PRES).</td></tr><tr><td style=\"white-space:nowrap\">ptld<a name=\"clinical-event-type-cs-ptld\"> </a></td><td>PTLD</td><td>Post-transplant lymphoproliferative disorder (PTLD).</td></tr><tr><td style=\"white-space:nowrap\">relapse-primary-immunomediated-disease<a name=\"clinical-event-type-cs-relapse-primary-immunomediated-disease\"> </a></td><td>Relapse Primary Immunomediated Disease</td><td>Recurrence of the primary immune-mediated disease that led to transplantation.</td></tr><tr><td style=\"white-space:nowrap\">renal-cni-toxicity<a name=\"clinical-event-type-cs-renal-cni-toxicity\"> </a></td><td>Renal CNI Toxicity</td><td>Calcineurin-inhibitor-induced renal toxicity.</td></tr><tr><td style=\"white-space:nowrap\">urological-complications<a name=\"clinical-event-type-cs-urological-complications\"> </a></td><td>Urological Complications</td><td>Post-transplant complications of the urinary tract (e.g. obstruction, leak, reflux).</td></tr><tr><td style=\"white-space:nowrap\">vascular-complications<a name=\"clinical-event-type-cs-vascular-complications\"> </a></td><td>Vascular Complications</td><td>Post-transplant vascular complications (e.g. thrombosis, stenosis).</td></tr></table></div>"
},
"url" : "https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/CodeSystem/clinical-event-type-cs",
"version" : "0.1.0-ci-build",
"name" : "ClinicalEventTypeCS",
"title" : "Clinical Event Type CodeSystem",
"status" : "draft",
"experimental" : true,
"date" : "2026-08-11T12:50:29+00:00",
"publisher" : "Protect Child",
"contact" : [
{
"name" : "Protect Child",
"telecom" : [
{
"system" : "url",
"value" : "https://protect-child.eu/"
}
]
}
],
"description" : "Types of clinical events in the PROTECT-CHILD study (DMv1.2), replacing outcome_type and post_event_type.",
"caseSensitive" : false,
"content" : "complete",
"count" : 26,
"concept" : [
{
"code" : "alloimmunization",
"display" : "Alloimmunization",
"definition" : "Development of antibodies against alloantigens (e.g. HLA) following transplantation or transfusion."
},
{
"code" : "biliary-complications",
"display" : "Biliary Complications",
"definition" : "Post-transplant complications of the biliary tract (e.g. stricture, leak, stones)."
},
{
"code" : "bk-virus-infection",
"display" : "BK Virus Infection",
"definition" : "Infection or reactivation of BK polyomavirus."
},
{
"code" : "chronic-liver-failure",
"display" : "Chronic Liver Failure",
"definition" : "Progressive, long-standing loss of liver function."
},
{
"code" : "chronic-liver-rejection",
"display" : "Chronic Liver Rejection",
"definition" : "Chronic rejection of the liver allograft (e.g. ductopenia / vanishing bile duct syndrome)."
},
{
"code" : "chronic-renal-failure-after-pltx",
"display" : "Chronic Renal Failure After pLTx",
"definition" : "Chronic kidney disease developing after paediatric liver transplantation."
},
{
"code" : "cmv-infection",
"display" : "Cytomegalovirus Infection",
"definition" : "Infection or reactivation of cytomegalovirus."
},
{
"code" : "delayed-kidney-graft-function",
"display" : "Delayed Kidney Graft Function",
"definition" : "Delayed function of the kidney allograft requiring dialysis in the first post-transplant week."
},
{
"code" : "diabetes",
"display" : "Diabetes",
"definition" : "Diabetes mellitus, including new-onset diabetes after transplantation."
},
{
"code" : "graft-failure",
"display" : "Graft Failure",
"definition" : "Loss of function of the transplanted organ."
},
{
"code" : "high-blood-pressure",
"display" : "High Blood Pressure",
"definition" : "Arterial hypertension."
},
{
"code" : "kidney-primary-non-function",
"display" : "Kidney Primary Non-Function",
"definition" : "Kidney allograft that never achieves function after transplantation."
},
{
"code" : "kidney-rejection-episode",
"display" : "Kidney Rejection Episode",
"definition" : "An episode of acute or chronic rejection of the kidney allograft."
},
{
"code" : "liver-early-allograft-dysfunction",
"display" : "Liver Early Allograft Dysfunction",
"definition" : "Early dysfunction of the liver allograft in the initial post-transplant period."
},
{
"code" : "liver-primary-non-function",
"display" : "Liver Primary Non-Function",
"definition" : "Liver allograft that never achieves function, requiring urgent re-transplantation."
},
{
"code" : "liver-rejection-episode",
"display" : "Liver Rejection Episode",
"definition" : "An episode of acute or chronic rejection of the liver allograft."
},
{
"code" : "microangiopathy",
"display" : "Microangiopathy",
"definition" : "Thrombotic microangiopathy affecting small blood vessels."
},
{
"code" : "mortality",
"display" : "Mortality",
"definition" : "Death of the patient."
},
{
"code" : "mtor-inhibitors-toxicity",
"display" : "mTOR Inhibitors Toxicity",
"definition" : "Adverse effects attributable to mTOR-inhibitor immunosuppression."
},
{
"code" : "mycophenolate-toxicity",
"display" : "Mycophenolate Toxicity",
"definition" : "Adverse effects attributable to mycophenolate immunosuppression."
},
{
"code" : "pres",
"display" : "PRES",
"definition" : "Posterior reversible encephalopathy syndrome (PRES)."
},
{
"code" : "ptld",
"display" : "PTLD",
"definition" : "Post-transplant lymphoproliferative disorder (PTLD)."
},
{
"code" : "relapse-primary-immunomediated-disease",
"display" : "Relapse Primary Immunomediated Disease",
"definition" : "Recurrence of the primary immune-mediated disease that led to transplantation."
},
{
"code" : "renal-cni-toxicity",
"display" : "Renal CNI Toxicity",
"definition" : "Calcineurin-inhibitor-induced renal toxicity."
},
{
"code" : "urological-complications",
"display" : "Urological Complications",
"definition" : "Post-transplant complications of the urinary tract (e.g. obstruction, leak, reflux)."
},
{
"code" : "vascular-complications",
"display" : "Vascular Complications",
"definition" : "Post-transplant vascular complications (e.g. thrombosis, stenosis)."
}
]
}