Medication Scheme Implementation Guide, published by TEHIK. This guide is not an authorized publication; it is the continuous build for version 1.0.0 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/TEHIK-EE/ig-ee-medication-scheme/ and changes regularly. See the Directory of published versions

• Content
• Detailed Descriptions
• Mappings
• Examples
• XML
• JSON
• TTL

Resource Profile: EETISRenalFailureDS

Neerufuntsiooni puudulikkuse otsustustoe vastus. This profile is for the representation of patient's renal function failure and alerts about it so the medication can be adjusted according to failure degree.

Usages:

• Use this Profile: EETISMedicationOverview
• Refer to this Profile: EETISComposition
• Examples for this Profile: ClinicalUseDefinition/renal-function-failure

You can also check for usages in the FHIR IG Statistics

Formal Views of Profile Content

Description of Profiles, Differentials, Snapshots and how the different presentations work.

• Key Elements Table
• Differential Table
• Snapshot Table
• Statistics/References
• All

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
ClinicalUseDefinition	C	0..*	ClinicalUseDefinition	A single issue - either an indication, contraindication, interaction or an undesirable effect for a medicinal product, medication, device or procedure Constraints: cud-1
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
contained		1..1	Medication	Contained, inline Resources
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:affected		0..*	Reference(EETISMedicationStatement)	MedicationStatements affected by interactions. URL: https://fhir.ee/StructureDefinition/ee-tis-affected-medication-statements
extension:link		0..*	string	Additional information from external source. URL: https://fhir.ee/StructureDefinition/ee-tis-additional-information-link
extension:nephrotoxic		0..*	boolean	Is the medication nephrotoxic or not. URL: https://fhir.ee/StructureDefinition/ee-tis-nephrotoxic
extension:dosageModification		0..*	(Complex)	Recommendation for dosaging URL: https://fhir.ee/StructureDefinition/ee-tis-dosage-modification
extension:relatedObservation		0..*	Reference(Observation | Condition)	Observation/Condition which triggers renal function alert. URL: https://fhir.ee/StructureDefinition/ee-tis-related-observation-or-condition
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored
type	Σ	1..1	code	indication | contraindication | interaction | undesirable-effect | warning Binding: ClinicalUseDefinitionType (required): Overall defining type of this clinical use definition. Fixed Value: undesirable-effect
Slices for category	Σ	0..*	CodeableConcept	RenBase drugFormGroup ja failureDegree Slice: Unordered, Open by value:coding Binding: ClinicalUseDefinitionCategory (preferred): A categorisation for a clinical use information item.
category:drugFormGroup	Σ	0..1	CodeableConcept	A categorisation of the issue, primarily for dividing warnings into subject heading areas such as "Pregnancy", "Overdose" Binding: ClinicalUseDefinitionCategory (preferred): A categorisation for a clinical use information item.
coding	Σ	1..*	Coding	0 | 1 | 2 | 3 | 4 | 5| This is a fake system for example. Do NOT use it! Required Pattern: At least the following
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
system		1..1	uri	Identity of the terminology system Fixed Value: https://fhir.ee/drug-form-group
version		0..1	string	Version of the system - if relevant
code		0..1	code	Symbol in syntax defined by the system
display		0..1	string	Representation defined by the system
userSelected		0..1	boolean	If this coding was chosen directly by the user
category:failureDegree	Σ	0..1	CodeableConcept	A categorisation of the issue, primarily for dividing warnings into subject heading areas such as "Pregnancy", "Overdose" Binding: ClinicalUseDefinitionCategory (preferred): A categorisation for a clinical use information item.
coding	Σ	1..*	Coding	Failure degree 0-4. Neerupuudulikkuse aste: number + selgitus. This is a fake system for example. Do NOT use it! Required Pattern: At least the following
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
system		1..1	uri	Identity of the terminology system Fixed Value: https://fhir.ee/failure-degree
version		0..1	string	Version of the system - if relevant
code		0..1	code	Symbol in syntax defined by the system
display		0..1	string	Representation defined by the system
userSelected		0..1	boolean	If this coding was chosen directly by the user
category:additionalInformation	Σ	0..1	CodeableConcept	A categorisation of the issue, primarily for dividing warnings into subject heading areas such as "Pregnancy", "Overdose" Binding: ClinicalUseDefinitionCategory (preferred): A categorisation for a clinical use information item.
coding	Σ	1..*	Coding	This is a fake system for example. Do NOT use it Required Pattern: At least the following
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
system		1..1	uri	Identity of the terminology system Fixed Value: https://fhir.ee/additional-information
version		0..1	string	Version of the system - if relevant
code		0..1	code	Symbol in syntax defined by the system
display		0..1	string	Representation defined by the system
userSelected		0..1	boolean	If this coding was chosen directly by the user
subject	Σ	1..*	Reference(Medication)	medication that may cause renal function failure
reference	ΣC	0..1	string	Literal reference, Relative, internal or absolute URL
display	ΣC	0..1	string	Text alternative for the resource Required Pattern: Name of the medication/active inredient. Siia toimeaine nimetus
undesirableEffect	ΣC	0..1	BackboneElement	Classification A/B/C/D and description how the dosage must be adjusted
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
classification	Σ	0..1	CodeableConcept	klassifikatsioon (A/B/C/D) + selle tekst nt C, text: Annust või annustamise vahemikku tuleb kohandada Binding: UndesirableEffectClassification (example): Use this fictive system https://fhir.ee/synbase-warning-classification
Documentation for this format

Terminology Bindings

Path	Conformance	ValueSet / Code	URI
ClinicalUseDefinition.type	required	Fixed Value: undesirable-effect http://hl7.org/fhir/ValueSet/clinical-use-definition-type|5.0.0 From the FHIR Standard
ClinicalUseDefinition.category	preferred	ClinicalUseDefinitionCategory http://hl7.org/fhir/ValueSet/clinical-use-definition-category|5.0.0 From the FHIR Standard
ClinicalUseDefinition.category:drugFormGroup	preferred	ClinicalUseDefinitionCategory http://hl7.org/fhir/ValueSet/clinical-use-definition-category|5.0.0 From the FHIR Standard
ClinicalUseDefinition.category:failureDegree	preferred	ClinicalUseDefinitionCategory http://hl7.org/fhir/ValueSet/clinical-use-definition-category|5.0.0 From the FHIR Standard
ClinicalUseDefinition.category:additionalInformation	preferred	ClinicalUseDefinitionCategory http://hl7.org/fhir/ValueSet/clinical-use-definition-category|5.0.0 From the FHIR Standard
ClinicalUseDefinition.undesirableEffect.classification	example	UndesirableEffectClassification http://hl7.org/fhir/ValueSet/undesirable-effect-classification From the FHIR Standard

Constraints

Id	Grade	Path(s)	Details	Requirements
cud-1	error	ClinicalUseDefinition	Indication, Contraindication, Interaction, UndesirableEffect and Warning cannot be used in the same instance : (ClinicalUseDefinition.indication.count() + ClinicalUseDefinition.contraindication.count() + ClinicalUseDefinition.interaction.count() + ClinicalUseDefinition.undesirableEffect.count() + ClinicalUseDefinition.warning.count()) < 2
dom-2	error	ClinicalUseDefinition	If the resource is contained in another resource, it SHALL NOT contain nested Resources : contained.contained.empty()
dom-3	error	ClinicalUseDefinition	If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource : contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().ofType(canonical) | %resource.descendants().ofType(uri) | %resource.descendants().ofType(url))) or descendants().where(reference = '#').exists() or descendants().where(ofType(canonical) = '#').exists() or descendants().where(ofType(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4	error	ClinicalUseDefinition	If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated : contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5	error	ClinicalUseDefinition	If a resource is contained in another resource, it SHALL NOT have a security label : contained.meta.security.empty()
dom-6	best practice	ClinicalUseDefinition	A resource should have narrative for robust management : text.`div`.exists()
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children : hasValue() or (children().count() > id.count())
ext-1	error	**ALL** extensions	Must have either extensions or value[x], not both : extension.exists() != value.exists()

This structure is derived from ClinicalUseDefinition

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
ClinicalUseDefinition			ClinicalUseDefinition
contained		1..1	Medication	Contained, inline Resources
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:affected		0..*	Reference(EETISMedicationStatement)	MedicationStatements affected by interactions. URL: https://fhir.ee/StructureDefinition/ee-tis-affected-medication-statements
extension:link		0..*	string	Additional information from external source. URL: https://fhir.ee/StructureDefinition/ee-tis-additional-information-link
extension:nephrotoxic		0..*	boolean	Is the medication nephrotoxic or not. URL: https://fhir.ee/StructureDefinition/ee-tis-nephrotoxic
extension:dosageModification		0..*	(Complex)	Recommendation for dosaging URL: https://fhir.ee/StructureDefinition/ee-tis-dosage-modification
extension:relatedObservation		0..*	Reference(Observation | Condition)	Observation/Condition which triggers renal function alert. URL: https://fhir.ee/StructureDefinition/ee-tis-related-observation-or-condition
type		1..1	code	indication | contraindication | interaction | undesirable-effect | warning Fixed Value: undesirable-effect
Slices for category		0..*	CodeableConcept	RenBase drugFormGroup ja failureDegree Slice: Unordered, Open by value:coding
category:drugFormGroup		0..1	CodeableConcept	A categorisation of the issue, primarily for dividing warnings into subject heading areas such as "Pregnancy", "Overdose"
coding		1..*	Coding	0 | 1 | 2 | 3 | 4 | 5| This is a fake system for example. Do NOT use it! Required Pattern: At least the following
system		1..1	uri	Identity of the terminology system Fixed Value: https://fhir.ee/drug-form-group
category:failureDegree		0..1	CodeableConcept	A categorisation of the issue, primarily for dividing warnings into subject heading areas such as "Pregnancy", "Overdose"
coding		1..*	Coding	Failure degree 0-4. Neerupuudulikkuse aste: number + selgitus. This is a fake system for example. Do NOT use it! Required Pattern: At least the following
system		1..1	uri	Identity of the terminology system Fixed Value: https://fhir.ee/failure-degree
category:additionalInformation		0..1	CodeableConcept	A categorisation of the issue, primarily for dividing warnings into subject heading areas such as "Pregnancy", "Overdose"
coding		1..*	Coding	This is a fake system for example. Do NOT use it Required Pattern: At least the following
system		1..1	uri	Identity of the terminology system Fixed Value: https://fhir.ee/additional-information
subject		1..*	Reference(Medication)	medication that may cause renal function failure
display		0..1	string	Text alternative for the resource Required Pattern: Name of the medication/active inredient. Siia toimeaine nimetus
contraindication		0..0
indication		0..0
population		0..0
library		0..0
undesirableEffect		0..1	BackboneElement	Classification A/B/C/D and description how the dosage must be adjusted
classification		0..1	CodeableConcept	klassifikatsioon (A/B/C/D) + selle tekst nt C, text: Annust või annustamise vahemikku tuleb kohandada Binding: UndesirableEffectClassification (example): Use this fictive system https://fhir.ee/synbase-warning-classification
Documentation for this format

Terminology Bindings (Differential)

Path	Conformance	ValueSet	URI
ClinicalUseDefinition.undesirableEffect.classification	example	UndesirableEffectClassification http://hl7.org/fhir/ValueSet/undesirable-effect-classification From the FHIR Standard

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
ClinicalUseDefinition	C	0..*	ClinicalUseDefinition	A single issue - either an indication, contraindication, interaction or an undesirable effect for a medicinal product, medication, device or procedure Constraints: cud-1
id	Σ	0..1	id	Logical id of this artifact
meta	Σ	0..1	Meta	Metadata about the resource
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
language		0..1	code	Language of the resource content Binding: AllLanguages (required): IETF language tag for a human language Additional Bindings Purpose CommonLanguages Starter
text		0..1	Narrative	Text summary of the resource, for human interpretation This profile does not constrain the narrative in regard to content, language, or traceability to data elements
contained		1..1	Medication	Contained, inline Resources
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:affected		0..*	Reference(EETISMedicationStatement)	MedicationStatements affected by interactions. URL: https://fhir.ee/StructureDefinition/ee-tis-affected-medication-statements
extension:link		0..*	string	Additional information from external source. URL: https://fhir.ee/StructureDefinition/ee-tis-additional-information-link
extension:nephrotoxic		0..*	boolean	Is the medication nephrotoxic or not. URL: https://fhir.ee/StructureDefinition/ee-tis-nephrotoxic
extension:dosageModification		0..*	(Complex)	Recommendation for dosaging URL: https://fhir.ee/StructureDefinition/ee-tis-dosage-modification
extension:relatedObservation		0..*	Reference(Observation | Condition)	Observation/Condition which triggers renal function alert. URL: https://fhir.ee/StructureDefinition/ee-tis-related-observation-or-condition
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored
identifier	Σ	0..*	Identifier	Business identifier for this issue
type	Σ	1..1	code	indication | contraindication | interaction | undesirable-effect | warning Binding: ClinicalUseDefinitionType (required): Overall defining type of this clinical use definition. Fixed Value: undesirable-effect
Slices for category	Σ	0..*	CodeableConcept	RenBase drugFormGroup ja failureDegree Slice: Unordered, Open by value:coding Binding: ClinicalUseDefinitionCategory (preferred): A categorisation for a clinical use information item.
category:drugFormGroup	Σ	0..1	CodeableConcept	A categorisation of the issue, primarily for dividing warnings into subject heading areas such as "Pregnancy", "Overdose" Binding: ClinicalUseDefinitionCategory (preferred): A categorisation for a clinical use information item.
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	Σ	1..*	Coding	0 | 1 | 2 | 3 | 4 | 5| This is a fake system for example. Do NOT use it! Required Pattern: At least the following
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
system		1..1	uri	Identity of the terminology system Fixed Value: https://fhir.ee/drug-form-group
version		0..1	string	Version of the system - if relevant
code		0..1	code	Symbol in syntax defined by the system
display		0..1	string	Representation defined by the system
userSelected		0..1	boolean	If this coding was chosen directly by the user
text	Σ	0..1	string	Plain text representation of the concept
category:failureDegree	Σ	0..1	CodeableConcept	A categorisation of the issue, primarily for dividing warnings into subject heading areas such as "Pregnancy", "Overdose" Binding: ClinicalUseDefinitionCategory (preferred): A categorisation for a clinical use information item.
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	Σ	1..*	Coding	Failure degree 0-4. Neerupuudulikkuse aste: number + selgitus. This is a fake system for example. Do NOT use it! Required Pattern: At least the following
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
system		1..1	uri	Identity of the terminology system Fixed Value: https://fhir.ee/failure-degree
version		0..1	string	Version of the system - if relevant
code		0..1	code	Symbol in syntax defined by the system
display		0..1	string	Representation defined by the system
userSelected		0..1	boolean	If this coding was chosen directly by the user
text	Σ	0..1	string	Plain text representation of the concept
category:additionalInformation	Σ	0..1	CodeableConcept	A categorisation of the issue, primarily for dividing warnings into subject heading areas such as "Pregnancy", "Overdose" Binding: ClinicalUseDefinitionCategory (preferred): A categorisation for a clinical use information item.
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	Σ	1..*	Coding	This is a fake system for example. Do NOT use it Required Pattern: At least the following
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
system		1..1	uri	Identity of the terminology system Fixed Value: https://fhir.ee/additional-information
version		0..1	string	Version of the system - if relevant
code		0..1	code	Symbol in syntax defined by the system
display		0..1	string	Representation defined by the system
userSelected		0..1	boolean	If this coding was chosen directly by the user
text	Σ	0..1	string	Plain text representation of the concept
subject	Σ	1..*	Reference(Medication)	medication that may cause renal function failure
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
reference	ΣC	0..1	string	Literal reference, Relative, internal or absolute URL
type	Σ	0..1	uri	Type the reference refers to (e.g. "Patient") - must be a resource in resources Binding: ResourceType (extensible): Aa resource (or, for logical models, the URI of the logical model).
identifier	ΣC	0..1	Identifier	Logical reference, when literal reference is not known
display	ΣC	0..1	string	Text alternative for the resource Required Pattern: Name of the medication/active inredient. Siia toimeaine nimetus
status	Σ	0..1	CodeableConcept	Whether this is a current issue or one that has been retired etc Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
interaction	ΣC	0..1	BackboneElement	Specifics for when this is an interaction
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
interactant	Σ	0..*	BackboneElement	The specific medication, product, food etc. or laboratory test that interacts
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
item[x]	Σ	1..1		The specific medication, product, food etc. or laboratory test that interacts Binding: Interactant (example): An interactant - a substance that may have a clinically significant effect on another.
itemReference			Reference(MedicinalProductDefinition | Medication | Substance | NutritionProduct | BiologicallyDerivedProduct | ObservationDefinition)
itemCodeableConcept			CodeableConcept
type	Σ	0..1	CodeableConcept	The type of the interaction e.g. drug-drug interaction, drug-lab test interaction Binding: InteractionType (example): A categorisation for an interaction between two substances.
effect	Σ	0..1	CodeableReference(ObservationDefinition)	The effect of the interaction, for example "reduced gastric absorption of primary medication" Binding: InteractionEffect (example): A interaction effect of clinical use of a medication or other substance.
incidence	Σ	0..1	CodeableConcept	The incidence of the interaction, e.g. theoretical, observed Binding: InteractionIncidence (example): A categorisation for incidence of occurence of an interaction.
management	Σ	0..*	CodeableConcept	Actions for managing the interaction Binding: InteractionManagement (example): A type of management for an interaction of a medication or other substance.
undesirableEffect	ΣC	0..1	BackboneElement	Classification A/B/C/D and description how the dosage must be adjusted
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
symptomConditionEffect	Σ	0..1	CodeableReference(ObservationDefinition)	The situation in which the undesirable effect may manifest Binding: UndesirableEffectSymptom (example): An undesirable effect of clinical use.
classification	Σ	0..1	CodeableConcept	klassifikatsioon (A/B/C/D) + selle tekst nt C, text: Annust või annustamise vahemikku tuleb kohandada Binding: UndesirableEffectClassification (example): Use this fictive system https://fhir.ee/synbase-warning-classification
frequencyOfOccurrence	Σ	0..1	CodeableConcept	How often the effect is seen Binding: UndesirablEffectFrequency (example): A categorisation for a frequency of occurence of an undesirable effect.
warning	ΣC	0..1	BackboneElement	Critical environmental, health or physical risks or hazards. For example 'Do not operate heavy machinery', 'May cause drowsiness'
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description	Σ	0..1	markdown	A textual definition of this warning, with formatting
code	Σ	0..1	CodeableConcept	A coded or unformatted textual definition of this warning Binding: WarningType (example): Classification of warning type.
Documentation for this format

Terminology Bindings

Path	Conformance	ValueSet / Code	URI
ClinicalUseDefinition.language	required	AllLanguages http://hl7.org/fhir/ValueSet/all-languages|5.0.0 From the FHIR Standard
ClinicalUseDefinition.type	required	Fixed Value: undesirable-effect http://hl7.org/fhir/ValueSet/clinical-use-definition-type|5.0.0 From the FHIR Standard
ClinicalUseDefinition.category	preferred	ClinicalUseDefinitionCategory http://hl7.org/fhir/ValueSet/clinical-use-definition-category|5.0.0 From the FHIR Standard
ClinicalUseDefinition.category:drugFormGroup	preferred	ClinicalUseDefinitionCategory http://hl7.org/fhir/ValueSet/clinical-use-definition-category|5.0.0 From the FHIR Standard
ClinicalUseDefinition.category:failureDegree	preferred	ClinicalUseDefinitionCategory http://hl7.org/fhir/ValueSet/clinical-use-definition-category|5.0.0 From the FHIR Standard
ClinicalUseDefinition.category:additionalInformation	preferred	ClinicalUseDefinitionCategory http://hl7.org/fhir/ValueSet/clinical-use-definition-category|5.0.0 From the FHIR Standard
ClinicalUseDefinition.subject.type	extensible	ResourceType http://hl7.org/fhir/ValueSet/resource-types|5.0.0 From the FHIR Standard
ClinicalUseDefinition.status	preferred	PublicationStatus http://hl7.org/fhir/ValueSet/publication-status|5.0.0 From the FHIR Standard
ClinicalUseDefinition.contraindication.diseaseSymptomProcedure	example	DiseaseSymptomProcedure http://hl7.org/fhir/ValueSet/disease-symptom-procedure|5.0.0 From the FHIR Standard
ClinicalUseDefinition.contraindication.diseaseStatus	example	DiseaseStatus http://hl7.org/fhir/ValueSet/disease-status|5.0.0 From the FHIR Standard
ClinicalUseDefinition.contraindication.comorbidity	example	DiseaseSymptomProcedure http://hl7.org/fhir/ValueSet/disease-symptom-procedure|5.0.0 From the FHIR Standard
ClinicalUseDefinition.contraindication.otherTherapy.relationshipType	preferred	TherapyRelationshipType http://hl7.org/fhir/ValueSet/therapy-relationship-type|5.0.0 From the FHIR Standard
ClinicalUseDefinition.contraindication.otherTherapy.treatment	example	Therapy http://hl7.org/fhir/ValueSet/therapy|5.0.0 From the FHIR Standard
ClinicalUseDefinition.indication.diseaseSymptomProcedure	example	DiseaseSymptomProcedure http://hl7.org/fhir/ValueSet/disease-symptom-procedure|5.0.0 From the FHIR Standard
ClinicalUseDefinition.indication.diseaseStatus	example	DiseaseStatus http://hl7.org/fhir/ValueSet/disease-status|5.0.0 From the FHIR Standard
ClinicalUseDefinition.indication.comorbidity	example	DiseaseSymptomProcedure http://hl7.org/fhir/ValueSet/disease-symptom-procedure|5.0.0 From the FHIR Standard
ClinicalUseDefinition.indication.intendedEffect	preferred	ProductIntendedUse http://hl7.org/fhir/ValueSet/product-intended-use|5.0.0 From the FHIR Standard
ClinicalUseDefinition.interaction.interactant.item[x]	example	Interactant http://hl7.org/fhir/ValueSet/interactant|5.0.0 From the FHIR Standard
ClinicalUseDefinition.interaction.type	example	InteractionType http://hl7.org/fhir/ValueSet/interaction-type|5.0.0 From the FHIR Standard
ClinicalUseDefinition.interaction.effect	example	InteractionEffect http://hl7.org/fhir/ValueSet/interaction-effect|5.0.0 From the FHIR Standard
ClinicalUseDefinition.interaction.incidence	example	InteractionIncidence http://hl7.org/fhir/ValueSet/interaction-incidence|5.0.0 From the FHIR Standard
ClinicalUseDefinition.interaction.management	example	InteractionManagement http://hl7.org/fhir/ValueSet/interaction-management|5.0.0 From the FHIR Standard
ClinicalUseDefinition.undesirableEffect.symptomConditionEffect	example	UndesirableEffectSymptom http://hl7.org/fhir/ValueSet/undesirable-effect-symptom|5.0.0 From the FHIR Standard
ClinicalUseDefinition.undesirableEffect.classification	example	UndesirableEffectClassification http://hl7.org/fhir/ValueSet/undesirable-effect-classification From the FHIR Standard
ClinicalUseDefinition.undesirableEffect.frequencyOfOccurrence	example	UndesirablEffectFrequency http://hl7.org/fhir/ValueSet/undesirable-effect-frequency|5.0.0 From the FHIR Standard
ClinicalUseDefinition.warning.code	example	WarningType http://hl7.org/fhir/ValueSet/warning-type|5.0.0 From the FHIR Standard

Constraints

Id	Grade	Path(s)	Details	Requirements
cud-1	error	ClinicalUseDefinition	Indication, Contraindication, Interaction, UndesirableEffect and Warning cannot be used in the same instance : (ClinicalUseDefinition.indication.count() + ClinicalUseDefinition.contraindication.count() + ClinicalUseDefinition.interaction.count() + ClinicalUseDefinition.undesirableEffect.count() + ClinicalUseDefinition.warning.count()) < 2
dom-2	error	ClinicalUseDefinition	If the resource is contained in another resource, it SHALL NOT contain nested Resources : contained.contained.empty()
dom-3	error	ClinicalUseDefinition	If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource : contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().ofType(canonical) | %resource.descendants().ofType(uri) | %resource.descendants().ofType(url))) or descendants().where(reference = '#').exists() or descendants().where(ofType(canonical) = '#').exists() or descendants().where(ofType(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4	error	ClinicalUseDefinition	If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated : contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5	error	ClinicalUseDefinition	If a resource is contained in another resource, it SHALL NOT have a security label : contained.meta.security.empty()
dom-6	best practice	ClinicalUseDefinition	A resource should have narrative for robust management : text.`div`.exists()
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children : hasValue() or (children().count() > id.count())
ext-1	error	**ALL** extensions	Must have either extensions or value[x], not both : extension.exists() != value.exists()

This structure is derived from ClinicalUseDefinition

Summary

Mandatory: 2 elements(3 nested mandatory elements)
Fixed: 1 element
Prohibited: 4 elements

Extensions

This structure refers to these extensions:

• https://fhir.ee/StructureDefinition/ee-tis-affected-medication-statements
• https://fhir.ee/StructureDefinition/ee-tis-additional-information-link
• https://fhir.ee/StructureDefinition/ee-tis-nephrotoxic
• https://fhir.ee/StructureDefinition/ee-tis-dosage-modification
• https://fhir.ee/StructureDefinition/ee-tis-related-observation-or-condition

Slices

This structure defines the following Slices:

• The element 1 is sliced based on the value of ClinicalUseDefinition.category

Key Elements View

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
ClinicalUseDefinition	C	0..*	ClinicalUseDefinition	A single issue - either an indication, contraindication, interaction or an undesirable effect for a medicinal product, medication, device or procedure Constraints: cud-1
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
contained		1..1	Medication	Contained, inline Resources
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:affected		0..*	Reference(EETISMedicationStatement)	MedicationStatements affected by interactions. URL: https://fhir.ee/StructureDefinition/ee-tis-affected-medication-statements
extension:link		0..*	string	Additional information from external source. URL: https://fhir.ee/StructureDefinition/ee-tis-additional-information-link
extension:nephrotoxic		0..*	boolean	Is the medication nephrotoxic or not. URL: https://fhir.ee/StructureDefinition/ee-tis-nephrotoxic
extension:dosageModification		0..*	(Complex)	Recommendation for dosaging URL: https://fhir.ee/StructureDefinition/ee-tis-dosage-modification
extension:relatedObservation		0..*	Reference(Observation | Condition)	Observation/Condition which triggers renal function alert. URL: https://fhir.ee/StructureDefinition/ee-tis-related-observation-or-condition
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored
type	Σ	1..1	code	indication | contraindication | interaction | undesirable-effect | warning Binding: ClinicalUseDefinitionType (required): Overall defining type of this clinical use definition. Fixed Value: undesirable-effect
Slices for category	Σ	0..*	CodeableConcept	RenBase drugFormGroup ja failureDegree Slice: Unordered, Open by value:coding Binding: ClinicalUseDefinitionCategory (preferred): A categorisation for a clinical use information item.
category:drugFormGroup	Σ	0..1	CodeableConcept	A categorisation of the issue, primarily for dividing warnings into subject heading areas such as "Pregnancy", "Overdose" Binding: ClinicalUseDefinitionCategory (preferred): A categorisation for a clinical use information item.
coding	Σ	1..*	Coding	0 | 1 | 2 | 3 | 4 | 5| This is a fake system for example. Do NOT use it! Required Pattern: At least the following
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
system		1..1	uri	Identity of the terminology system Fixed Value: https://fhir.ee/drug-form-group
version		0..1	string	Version of the system - if relevant
code		0..1	code	Symbol in syntax defined by the system
display		0..1	string	Representation defined by the system
userSelected		0..1	boolean	If this coding was chosen directly by the user
category:failureDegree	Σ	0..1	CodeableConcept	A categorisation of the issue, primarily for dividing warnings into subject heading areas such as "Pregnancy", "Overdose" Binding: ClinicalUseDefinitionCategory (preferred): A categorisation for a clinical use information item.
coding	Σ	1..*	Coding	Failure degree 0-4. Neerupuudulikkuse aste: number + selgitus. This is a fake system for example. Do NOT use it! Required Pattern: At least the following
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
system		1..1	uri	Identity of the terminology system Fixed Value: https://fhir.ee/failure-degree
version		0..1	string	Version of the system - if relevant
code		0..1	code	Symbol in syntax defined by the system
display		0..1	string	Representation defined by the system
userSelected		0..1	boolean	If this coding was chosen directly by the user
category:additionalInformation	Σ	0..1	CodeableConcept	A categorisation of the issue, primarily for dividing warnings into subject heading areas such as "Pregnancy", "Overdose" Binding: ClinicalUseDefinitionCategory (preferred): A categorisation for a clinical use information item.
coding	Σ	1..*	Coding	This is a fake system for example. Do NOT use it Required Pattern: At least the following
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
system		1..1	uri	Identity of the terminology system Fixed Value: https://fhir.ee/additional-information
version		0..1	string	Version of the system - if relevant
code		0..1	code	Symbol in syntax defined by the system
display		0..1	string	Representation defined by the system
userSelected		0..1	boolean	If this coding was chosen directly by the user
subject	Σ	1..*	Reference(Medication)	medication that may cause renal function failure
reference	ΣC	0..1	string	Literal reference, Relative, internal or absolute URL
display	ΣC	0..1	string	Text alternative for the resource Required Pattern: Name of the medication/active inredient. Siia toimeaine nimetus
undesirableEffect	ΣC	0..1	BackboneElement	Classification A/B/C/D and description how the dosage must be adjusted
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
classification	Σ	0..1	CodeableConcept	klassifikatsioon (A/B/C/D) + selle tekst nt C, text: Annust või annustamise vahemikku tuleb kohandada Binding: UndesirableEffectClassification (example): Use this fictive system https://fhir.ee/synbase-warning-classification
Documentation for this format

Terminology Bindings

Path	Conformance	ValueSet / Code	URI
ClinicalUseDefinition.type	required	Fixed Value: undesirable-effect http://hl7.org/fhir/ValueSet/clinical-use-definition-type|5.0.0 From the FHIR Standard
ClinicalUseDefinition.category	preferred	ClinicalUseDefinitionCategory http://hl7.org/fhir/ValueSet/clinical-use-definition-category|5.0.0 From the FHIR Standard
ClinicalUseDefinition.category:drugFormGroup	preferred	ClinicalUseDefinitionCategory http://hl7.org/fhir/ValueSet/clinical-use-definition-category|5.0.0 From the FHIR Standard
ClinicalUseDefinition.category:failureDegree	preferred	ClinicalUseDefinitionCategory http://hl7.org/fhir/ValueSet/clinical-use-definition-category|5.0.0 From the FHIR Standard
ClinicalUseDefinition.category:additionalInformation	preferred	ClinicalUseDefinitionCategory http://hl7.org/fhir/ValueSet/clinical-use-definition-category|5.0.0 From the FHIR Standard
ClinicalUseDefinition.undesirableEffect.classification	example	UndesirableEffectClassification http://hl7.org/fhir/ValueSet/undesirable-effect-classification From the FHIR Standard

Constraints

Id	Grade	Path(s)	Details	Requirements
cud-1	error	ClinicalUseDefinition	Indication, Contraindication, Interaction, UndesirableEffect and Warning cannot be used in the same instance : (ClinicalUseDefinition.indication.count() + ClinicalUseDefinition.contraindication.count() + ClinicalUseDefinition.interaction.count() + ClinicalUseDefinition.undesirableEffect.count() + ClinicalUseDefinition.warning.count()) < 2
dom-2	error	ClinicalUseDefinition	If the resource is contained in another resource, it SHALL NOT contain nested Resources : contained.contained.empty()
dom-3	error	ClinicalUseDefinition	If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource : contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().ofType(canonical) | %resource.descendants().ofType(uri) | %resource.descendants().ofType(url))) or descendants().where(reference = '#').exists() or descendants().where(ofType(canonical) = '#').exists() or descendants().where(ofType(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4	error	ClinicalUseDefinition	If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated : contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5	error	ClinicalUseDefinition	If a resource is contained in another resource, it SHALL NOT have a security label : contained.meta.security.empty()
dom-6	best practice	ClinicalUseDefinition	A resource should have narrative for robust management : text.`div`.exists()
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children : hasValue() or (children().count() > id.count())
ext-1	error	**ALL** extensions	Must have either extensions or value[x], not both : extension.exists() != value.exists()

Differential View

This structure is derived from ClinicalUseDefinition

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
ClinicalUseDefinition			ClinicalUseDefinition
contained		1..1	Medication	Contained, inline Resources
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:affected		0..*	Reference(EETISMedicationStatement)	MedicationStatements affected by interactions. URL: https://fhir.ee/StructureDefinition/ee-tis-affected-medication-statements
extension:link		0..*	string	Additional information from external source. URL: https://fhir.ee/StructureDefinition/ee-tis-additional-information-link
extension:nephrotoxic		0..*	boolean	Is the medication nephrotoxic or not. URL: https://fhir.ee/StructureDefinition/ee-tis-nephrotoxic
extension:dosageModification		0..*	(Complex)	Recommendation for dosaging URL: https://fhir.ee/StructureDefinition/ee-tis-dosage-modification
extension:relatedObservation		0..*	Reference(Observation | Condition)	Observation/Condition which triggers renal function alert. URL: https://fhir.ee/StructureDefinition/ee-tis-related-observation-or-condition
type		1..1	code	indication | contraindication | interaction | undesirable-effect | warning Fixed Value: undesirable-effect
Slices for category		0..*	CodeableConcept	RenBase drugFormGroup ja failureDegree Slice: Unordered, Open by value:coding
category:drugFormGroup		0..1	CodeableConcept	A categorisation of the issue, primarily for dividing warnings into subject heading areas such as "Pregnancy", "Overdose"
coding		1..*	Coding	0 | 1 | 2 | 3 | 4 | 5| This is a fake system for example. Do NOT use it! Required Pattern: At least the following
system		1..1	uri	Identity of the terminology system Fixed Value: https://fhir.ee/drug-form-group
category:failureDegree		0..1	CodeableConcept	A categorisation of the issue, primarily for dividing warnings into subject heading areas such as "Pregnancy", "Overdose"
coding		1..*	Coding	Failure degree 0-4. Neerupuudulikkuse aste: number + selgitus. This is a fake system for example. Do NOT use it! Required Pattern: At least the following
system		1..1	uri	Identity of the terminology system Fixed Value: https://fhir.ee/failure-degree
category:additionalInformation		0..1	CodeableConcept	A categorisation of the issue, primarily for dividing warnings into subject heading areas such as "Pregnancy", "Overdose"
coding		1..*	Coding	This is a fake system for example. Do NOT use it Required Pattern: At least the following
system		1..1	uri	Identity of the terminology system Fixed Value: https://fhir.ee/additional-information
subject		1..*	Reference(Medication)	medication that may cause renal function failure
display		0..1	string	Text alternative for the resource Required Pattern: Name of the medication/active inredient. Siia toimeaine nimetus
contraindication		0..0
indication		0..0
population		0..0
library		0..0
undesirableEffect		0..1	BackboneElement	Classification A/B/C/D and description how the dosage must be adjusted
classification		0..1	CodeableConcept	klassifikatsioon (A/B/C/D) + selle tekst nt C, text: Annust või annustamise vahemikku tuleb kohandada Binding: UndesirableEffectClassification (example): Use this fictive system https://fhir.ee/synbase-warning-classification
Documentation for this format

Terminology Bindings (Differential)

Path	Conformance	ValueSet	URI
ClinicalUseDefinition.undesirableEffect.classification	example	UndesirableEffectClassification http://hl7.org/fhir/ValueSet/undesirable-effect-classification From the FHIR Standard

Snapshot View

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
ClinicalUseDefinition	C	0..*	ClinicalUseDefinition	A single issue - either an indication, contraindication, interaction or an undesirable effect for a medicinal product, medication, device or procedure Constraints: cud-1
id	Σ	0..1	id	Logical id of this artifact
meta	Σ	0..1	Meta	Metadata about the resource
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
language		0..1	code	Language of the resource content Binding: AllLanguages (required): IETF language tag for a human language Additional Bindings Purpose CommonLanguages Starter
text		0..1	Narrative	Text summary of the resource, for human interpretation This profile does not constrain the narrative in regard to content, language, or traceability to data elements
contained		1..1	Medication	Contained, inline Resources
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:affected		0..*	Reference(EETISMedicationStatement)	MedicationStatements affected by interactions. URL: https://fhir.ee/StructureDefinition/ee-tis-affected-medication-statements
extension:link		0..*	string	Additional information from external source. URL: https://fhir.ee/StructureDefinition/ee-tis-additional-information-link
extension:nephrotoxic		0..*	boolean	Is the medication nephrotoxic or not. URL: https://fhir.ee/StructureDefinition/ee-tis-nephrotoxic
extension:dosageModification		0..*	(Complex)	Recommendation for dosaging URL: https://fhir.ee/StructureDefinition/ee-tis-dosage-modification
extension:relatedObservation		0..*	Reference(Observation | Condition)	Observation/Condition which triggers renal function alert. URL: https://fhir.ee/StructureDefinition/ee-tis-related-observation-or-condition
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored
identifier	Σ	0..*	Identifier	Business identifier for this issue
type	Σ	1..1	code	indication | contraindication | interaction | undesirable-effect | warning Binding: ClinicalUseDefinitionType (required): Overall defining type of this clinical use definition. Fixed Value: undesirable-effect
Slices for category	Σ	0..*	CodeableConcept	RenBase drugFormGroup ja failureDegree Slice: Unordered, Open by value:coding Binding: ClinicalUseDefinitionCategory (preferred): A categorisation for a clinical use information item.
category:drugFormGroup	Σ	0..1	CodeableConcept	A categorisation of the issue, primarily for dividing warnings into subject heading areas such as "Pregnancy", "Overdose" Binding: ClinicalUseDefinitionCategory (preferred): A categorisation for a clinical use information item.
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	Σ	1..*	Coding	0 | 1 | 2 | 3 | 4 | 5| This is a fake system for example. Do NOT use it! Required Pattern: At least the following
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
system		1..1	uri	Identity of the terminology system Fixed Value: https://fhir.ee/drug-form-group
version		0..1	string	Version of the system - if relevant
code		0..1	code	Symbol in syntax defined by the system
display		0..1	string	Representation defined by the system
userSelected		0..1	boolean	If this coding was chosen directly by the user
text	Σ	0..1	string	Plain text representation of the concept
category:failureDegree	Σ	0..1	CodeableConcept	A categorisation of the issue, primarily for dividing warnings into subject heading areas such as "Pregnancy", "Overdose" Binding: ClinicalUseDefinitionCategory (preferred): A categorisation for a clinical use information item.
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	Σ	1..*	Coding	Failure degree 0-4. Neerupuudulikkuse aste: number + selgitus. This is a fake system for example. Do NOT use it! Required Pattern: At least the following
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
system		1..1	uri	Identity of the terminology system Fixed Value: https://fhir.ee/failure-degree
version		0..1	string	Version of the system - if relevant
code		0..1	code	Symbol in syntax defined by the system
display		0..1	string	Representation defined by the system
userSelected		0..1	boolean	If this coding was chosen directly by the user
text	Σ	0..1	string	Plain text representation of the concept
category:additionalInformation	Σ	0..1	CodeableConcept	A categorisation of the issue, primarily for dividing warnings into subject heading areas such as "Pregnancy", "Overdose" Binding: ClinicalUseDefinitionCategory (preferred): A categorisation for a clinical use information item.
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	Σ	1..*	Coding	This is a fake system for example. Do NOT use it Required Pattern: At least the following
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
system		1..1	uri	Identity of the terminology system Fixed Value: https://fhir.ee/additional-information
version		0..1	string	Version of the system - if relevant
code		0..1	code	Symbol in syntax defined by the system
display		0..1	string	Representation defined by the system
userSelected		0..1	boolean	If this coding was chosen directly by the user
text	Σ	0..1	string	Plain text representation of the concept
subject	Σ	1..*	Reference(Medication)	medication that may cause renal function failure
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
reference	ΣC	0..1	string	Literal reference, Relative, internal or absolute URL
type	Σ	0..1	uri	Type the reference refers to (e.g. "Patient") - must be a resource in resources Binding: ResourceType (extensible): Aa resource (or, for logical models, the URI of the logical model).
identifier	ΣC	0..1	Identifier	Logical reference, when literal reference is not known
display	ΣC	0..1	string	Text alternative for the resource Required Pattern: Name of the medication/active inredient. Siia toimeaine nimetus
status	Σ	0..1	CodeableConcept	Whether this is a current issue or one that has been retired etc Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
interaction	ΣC	0..1	BackboneElement	Specifics for when this is an interaction
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
interactant	Σ	0..*	BackboneElement	The specific medication, product, food etc. or laboratory test that interacts
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
item[x]	Σ	1..1		The specific medication, product, food etc. or laboratory test that interacts Binding: Interactant (example): An interactant - a substance that may have a clinically significant effect on another.
itemReference			Reference(MedicinalProductDefinition | Medication | Substance | NutritionProduct | BiologicallyDerivedProduct | ObservationDefinition)
itemCodeableConcept			CodeableConcept
type	Σ	0..1	CodeableConcept	The type of the interaction e.g. drug-drug interaction, drug-lab test interaction Binding: InteractionType (example): A categorisation for an interaction between two substances.
effect	Σ	0..1	CodeableReference(ObservationDefinition)	The effect of the interaction, for example "reduced gastric absorption of primary medication" Binding: InteractionEffect (example): A interaction effect of clinical use of a medication or other substance.
incidence	Σ	0..1	CodeableConcept	The incidence of the interaction, e.g. theoretical, observed Binding: InteractionIncidence (example): A categorisation for incidence of occurence of an interaction.
management	Σ	0..*	CodeableConcept	Actions for managing the interaction Binding: InteractionManagement (example): A type of management for an interaction of a medication or other substance.
undesirableEffect	ΣC	0..1	BackboneElement	Classification A/B/C/D and description how the dosage must be adjusted
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
symptomConditionEffect	Σ	0..1	CodeableReference(ObservationDefinition)	The situation in which the undesirable effect may manifest Binding: UndesirableEffectSymptom (example): An undesirable effect of clinical use.
classification	Σ	0..1	CodeableConcept	klassifikatsioon (A/B/C/D) + selle tekst nt C, text: Annust või annustamise vahemikku tuleb kohandada Binding: UndesirableEffectClassification (example): Use this fictive system https://fhir.ee/synbase-warning-classification
frequencyOfOccurrence	Σ	0..1	CodeableConcept	How often the effect is seen Binding: UndesirablEffectFrequency (example): A categorisation for a frequency of occurence of an undesirable effect.
warning	ΣC	0..1	BackboneElement	Critical environmental, health or physical risks or hazards. For example 'Do not operate heavy machinery', 'May cause drowsiness'
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description	Σ	0..1	markdown	A textual definition of this warning, with formatting
code	Σ	0..1	CodeableConcept	A coded or unformatted textual definition of this warning Binding: WarningType (example): Classification of warning type.
Documentation for this format

Terminology Bindings

Path	Conformance	ValueSet / Code	URI
ClinicalUseDefinition.language	required	AllLanguages http://hl7.org/fhir/ValueSet/all-languages|5.0.0 From the FHIR Standard
ClinicalUseDefinition.type	required	Fixed Value: undesirable-effect http://hl7.org/fhir/ValueSet/clinical-use-definition-type|5.0.0 From the FHIR Standard
ClinicalUseDefinition.category	preferred	ClinicalUseDefinitionCategory http://hl7.org/fhir/ValueSet/clinical-use-definition-category|5.0.0 From the FHIR Standard
ClinicalUseDefinition.category:drugFormGroup	preferred	ClinicalUseDefinitionCategory http://hl7.org/fhir/ValueSet/clinical-use-definition-category|5.0.0 From the FHIR Standard
ClinicalUseDefinition.category:failureDegree	preferred	ClinicalUseDefinitionCategory http://hl7.org/fhir/ValueSet/clinical-use-definition-category|5.0.0 From the FHIR Standard
ClinicalUseDefinition.category:additionalInformation	preferred	ClinicalUseDefinitionCategory http://hl7.org/fhir/ValueSet/clinical-use-definition-category|5.0.0 From the FHIR Standard
ClinicalUseDefinition.subject.type	extensible	ResourceType http://hl7.org/fhir/ValueSet/resource-types|5.0.0 From the FHIR Standard
ClinicalUseDefinition.status	preferred	PublicationStatus http://hl7.org/fhir/ValueSet/publication-status|5.0.0 From the FHIR Standard
ClinicalUseDefinition.contraindication.diseaseSymptomProcedure	example	DiseaseSymptomProcedure http://hl7.org/fhir/ValueSet/disease-symptom-procedure|5.0.0 From the FHIR Standard
ClinicalUseDefinition.contraindication.diseaseStatus	example	DiseaseStatus http://hl7.org/fhir/ValueSet/disease-status|5.0.0 From the FHIR Standard
ClinicalUseDefinition.contraindication.comorbidity	example	DiseaseSymptomProcedure http://hl7.org/fhir/ValueSet/disease-symptom-procedure|5.0.0 From the FHIR Standard
ClinicalUseDefinition.contraindication.otherTherapy.relationshipType	preferred	TherapyRelationshipType http://hl7.org/fhir/ValueSet/therapy-relationship-type|5.0.0 From the FHIR Standard
ClinicalUseDefinition.contraindication.otherTherapy.treatment	example	Therapy http://hl7.org/fhir/ValueSet/therapy|5.0.0 From the FHIR Standard
ClinicalUseDefinition.indication.diseaseSymptomProcedure	example	DiseaseSymptomProcedure http://hl7.org/fhir/ValueSet/disease-symptom-procedure|5.0.0 From the FHIR Standard
ClinicalUseDefinition.indication.diseaseStatus	example	DiseaseStatus http://hl7.org/fhir/ValueSet/disease-status|5.0.0 From the FHIR Standard
ClinicalUseDefinition.indication.comorbidity	example	DiseaseSymptomProcedure http://hl7.org/fhir/ValueSet/disease-symptom-procedure|5.0.0 From the FHIR Standard
ClinicalUseDefinition.indication.intendedEffect	preferred	ProductIntendedUse http://hl7.org/fhir/ValueSet/product-intended-use|5.0.0 From the FHIR Standard
ClinicalUseDefinition.interaction.interactant.item[x]	example	Interactant http://hl7.org/fhir/ValueSet/interactant|5.0.0 From the FHIR Standard
ClinicalUseDefinition.interaction.type	example	InteractionType http://hl7.org/fhir/ValueSet/interaction-type|5.0.0 From the FHIR Standard
ClinicalUseDefinition.interaction.effect	example	InteractionEffect http://hl7.org/fhir/ValueSet/interaction-effect|5.0.0 From the FHIR Standard
ClinicalUseDefinition.interaction.incidence	example	InteractionIncidence http://hl7.org/fhir/ValueSet/interaction-incidence|5.0.0 From the FHIR Standard
ClinicalUseDefinition.interaction.management	example	InteractionManagement http://hl7.org/fhir/ValueSet/interaction-management|5.0.0 From the FHIR Standard
ClinicalUseDefinition.undesirableEffect.symptomConditionEffect	example	UndesirableEffectSymptom http://hl7.org/fhir/ValueSet/undesirable-effect-symptom|5.0.0 From the FHIR Standard
ClinicalUseDefinition.undesirableEffect.classification	example	UndesirableEffectClassification http://hl7.org/fhir/ValueSet/undesirable-effect-classification From the FHIR Standard
ClinicalUseDefinition.undesirableEffect.frequencyOfOccurrence	example	UndesirablEffectFrequency http://hl7.org/fhir/ValueSet/undesirable-effect-frequency|5.0.0 From the FHIR Standard
ClinicalUseDefinition.warning.code	example	WarningType http://hl7.org/fhir/ValueSet/warning-type|5.0.0 From the FHIR Standard

Constraints

Id	Grade	Path(s)	Details	Requirements
cud-1	error	ClinicalUseDefinition	Indication, Contraindication, Interaction, UndesirableEffect and Warning cannot be used in the same instance : (ClinicalUseDefinition.indication.count() + ClinicalUseDefinition.contraindication.count() + ClinicalUseDefinition.interaction.count() + ClinicalUseDefinition.undesirableEffect.count() + ClinicalUseDefinition.warning.count()) < 2
dom-2	error	ClinicalUseDefinition	If the resource is contained in another resource, it SHALL NOT contain nested Resources : contained.contained.empty()
dom-3	error	ClinicalUseDefinition	If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource : contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().ofType(canonical) | %resource.descendants().ofType(uri) | %resource.descendants().ofType(url))) or descendants().where(reference = '#').exists() or descendants().where(ofType(canonical) = '#').exists() or descendants().where(ofType(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4	error	ClinicalUseDefinition	If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated : contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5	error	ClinicalUseDefinition	If a resource is contained in another resource, it SHALL NOT have a security label : contained.meta.security.empty()
dom-6	best practice	ClinicalUseDefinition	A resource should have narrative for robust management : text.`div`.exists()
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children : hasValue() or (children().count() > id.count())
ext-1	error	**ALL** extensions	Must have either extensions or value[x], not both : extension.exists() != value.exists()

This structure is derived from ClinicalUseDefinition

Summary

Mandatory: 2 elements(3 nested mandatory elements)
Fixed: 1 element
Prohibited: 4 elements

Extensions

This structure refers to these extensions:

• https://fhir.ee/StructureDefinition/ee-tis-affected-medication-statements
• https://fhir.ee/StructureDefinition/ee-tis-additional-information-link
• https://fhir.ee/StructureDefinition/ee-tis-nephrotoxic
• https://fhir.ee/StructureDefinition/ee-tis-dosage-modification
• https://fhir.ee/StructureDefinition/ee-tis-related-observation-or-condition

Slices

This structure defines the following Slices:

• The element 1 is sliced based on the value of ClinicalUseDefinition.category

Other representations of profile: CSV, Excel, Schematron