Pharmaceutical Quality (Industry)
1.0.0 - STU1 International flag

Pharmaceutical Quality (Industry), published by HL7 International / Biomedical Research and Regulation. This guide is not an authorized publication; it is the continuous build for version 1.0.0 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/uv-dx-pq/ and changes regularly. See the Directory of published versions

: Example: Bundle - Process Validation, substance - XML Representation

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<Bundle xmlns="http://hl7.org/fhir">
  <!--  Substance Process Validation  -->
  <id value="bundle-product-process-validation-pq-ex2-sub"/>
  <meta>
    <profile
             value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Bundle-product-process-validation-pq"/>
  </meta>
  <type value="collection"/>
  <entry>
    <fullUrl value="urn:uuid:2038e4c7-22b8-4c56-2d28-6c077648763f"/>
    <resource>
      <PlanDefinition>
        <!-- validationProtocol -->
        <id value="2038e4c7-22b8-4c56-2d28-6c077648763f"/>
        <text>
          <status value="extensions"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="PlanDefinition_2038e4c7-22b8-4c56-2d28-6c077648763f"> </a><p><b>Generated Narrative: PlanDefinition</b><a name="2038e4c7-22b8-4c56-2d28-6c077648763f"> </a><a name="hc2038e4c7-22b8-4c56-2d28-6c077648763f"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource PlanDefinition &quot;2038e4c7-22b8-4c56-2d28-6c077648763f&quot; </p></div><p><b>url</b>: <code>http://example-server.com/fhir/PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f</code></p><p><b>title</b>: DP PROCESS VALIDATION</p><p><b>type</b>: Workflow Definition <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.0.0/CodeSystem-plan-definition-type.html">PlanDefinitionType</a>#workflow-definition; <a href="CodeSystem-pharmaceutical-plan-type.html">Pharmaceutical Plan Type Codes</a>#process-validation &quot;Process Validation&quot;)</span></p><p><b>status</b>: active</p><p><b>subject</b>: See on this page: SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390</p><p><b>description</b>: Pre-defined validation acceptance criteria were established based on manufacturing development data derived from process characterization studies...</p><blockquote><p><b>action</b></p><p><b>Extension - Process Step Scale PQ</b>: Production Scale (Details: http://terminology.hl7.org/CodeSystem/manufacturing-step-scale code PROD = 'Production Scale', stated as 'Production Scale')</p><blockquote><p><b>Extension - Process Parameters PQ</b></p><blockquote><p><b>url</b></p><code>parameter</code></blockquote><p><b>value</b>: Mix speed <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-process-parameter.html">Process Parameter Codes</a>#SPEED)</span></p><blockquote><p><b>url</b></p><code>value</code></blockquote><p><b>value</b>: 1500 rpm</p></blockquote><p><b>prefix</b>: 1</p><p><b>title</b>: Step 1 Yield</p><p><b>description</b>: Description of this step</p><p><b>code</b>: Particle Size Reduction <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-manufacturing-step.html">Manufacturing Step Codes</a>#particleSizeReduction)</span></p><blockquote><p><b>participant</b></p><p><b>typeReference</b>: <span>: Starting material</span></p><p><b>role</b>: Starting Material <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-manufacturing-participant-role.html">Manufacturing Participant Role Codes</a>#StartingMaterial)</span></p></blockquote><blockquote><p><b>participant</b></p><p><b>typeReference</b>: <span>: Intermediate material</span></p><p><b>role</b>: Intermediate Material <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-manufacturing-participant-role.html">Manufacturing Participant Role Codes</a>#IntermediateMaterial)</span></p></blockquote><blockquote><p><b>participant</b></p><p><b>typeReference</b>: <span>: Resulting material</span></p><p><b>role</b>: Resulting Material <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-manufacturing-participant-role.html">Manufacturing Participant Role Codes</a>#ResultingMaterial)</span></p></blockquote><h3>Actions</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style="display: none">*</td><td>Test <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td><td><a href="http://example-server.com/fhir/ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72">http://example-server.com/fhir/ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72</a></td></tr></table></blockquote><blockquote><p><b>action</b></p><p><b>title</b>: Step 1 In-Process Control Data</p><p><b>code</b>: Step 1 In-Process Control Data <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-manufacturing-step.html">Manufacturing Step Codes</a>#Step1In-ProcessControlData)</span></p><h3>Actions</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style="display: none">*</td><td>Test <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td><td><a href="http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72">http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72</a></td></tr><tr><td style="display: none">*</td><td>Test <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td><td><a href="http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9ff1-91c2-2d16-57cb5b295e72">http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9ff1-91c2-2d16-57cb5b295e72</a></td></tr></table></blockquote><blockquote><p><b>action</b></p><p><b>title</b>: Step 1 DS Release Testing Results</p><p><b>code</b>: Step 1 DS Release Testing Results <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-manufacturing-step.html">Manufacturing Step Codes</a>#Step1DSReleaseTestingResults)</span></p><h3>Actions</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style="display: none">*</td><td>Test <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td><td><a href="http://example-server.com/fhir/ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72">http://example-server.com/fhir/ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72</a></td></tr><tr><td style="display: none">*</td><td>Test <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td><td><a href="http://example-server.com/fhir/ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d">http://example-server.com/fhir/ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d</a></td></tr><tr><td style="display: none">*</td><td>Test <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td><td><a href="http://example-server.com/fhir/ObservationDefinition/12e7e672-40a6-4036-3c1f-b8ba6a7d045e">http://example-server.com/fhir/ObservationDefinition/12e7e672-40a6-4036-3c1f-b8ba6a7d045e</a></td></tr></table></blockquote><blockquote><p><b>action</b></p><p><b>Extension - Process Step Scale PQ</b>: Production Scale (Details: http://terminology.hl7.org/CodeSystem/manufacturing-step-scale code PROD = 'Production Scale', stated as 'Production Scale')</p><p><b>prefix</b>: 2</p><p><b>title</b>: Step 2 Yield</p><p><b>description</b>: Description of this step</p><p><b>code</b>: Drying <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-manufacturing-step.html">Manufacturing Step Codes</a>#drying)</span></p><blockquote><p><b>participant</b></p><p><b>typeReference</b>: <span>: Starting material</span></p><p><b>role</b>: Starting Material <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-manufacturing-participant-role.html">Manufacturing Participant Role Codes</a>#StartingMaterial)</span></p></blockquote><blockquote><p><b>participant</b></p><p><b>typeReference</b>: <span>: Intermediate material</span></p><p><b>role</b>: Intermediate Material <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-manufacturing-participant-role.html">Manufacturing Participant Role Codes</a>#IntermediateMaterial)</span></p></blockquote><blockquote><p><b>participant</b></p><p><b>typeReference</b>: <span>: Resulting material</span></p><p><b>role</b>: Resulting Material <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-manufacturing-participant-role.html">Manufacturing Participant Role Codes</a>#ResultingMaterial)</span></p></blockquote><h3>Actions</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style="display: none">*</td><td>Test <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td><td><a href="http://example-server.com/fhir/ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72">http://example-server.com/fhir/ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72</a></td></tr></table></blockquote></div>
        </text>
        <!-- http://example-server.com/fhir/PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f -->
        <url
             value="http://example-server.com/fhir/PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f"/>
        <title value="DP PROCESS VALIDATION"/>
        <type>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/plan-definition-type"/>
            <code value="workflow-definition"/>
            <display value="Workflow Definition"/>
          </coding>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/pharmaceutical-plan-type"/>
            <code value="process-validation"/>
            <display value="Process Validation"/>
          </coding>
        </type>
        <status value="active"/>
        <subjectReference>
          <!-- SubstanceDefinition/substancedefinition-component-substance-dxpq-ex1 -->
          <reference
                     value="SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390"/>
        </subjectReference>
        <description
                     value="Pre-defined validation acceptance criteria were established based on manufacturing development data derived from process characterization studies..."/>
        <action>
          <extension
                     url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-process-step-scale-pq">
            <valueCoding>
              <system
                      value="http://terminology.hl7.org/CodeSystem/manufacturing-step-scale"/>
              <code value="PROD"/>
              <display value="Production Scale"/>
            </valueCoding>
          </extension>
          <extension
                     url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-process-parameters-pq">
            <extension url="parameter">
              <valueCodeableConcept>
                <coding>
                  <system
                          value="http://terminology.hl7.org/CodeSystem/process-parameter"/>
                  <code value="SPEED"/>
                  <display value="Mix speed"/>
                </coding>
              </valueCodeableConcept>
            </extension>
            <extension url="value">
              <valueQuantity>
                <value value="1500"/>
                <unit value="rpm"/>
              </valueQuantity>
            </extension>
          </extension>
          <prefix value="1"/>
          <title value="Step 1 Yield"/>
          <description value="Description of this step"/>
          <!-- text value="Step 2 in the process - free text is possible"/ -->
          <code>
            <coding>
              <system
                      value="http://terminology.hl7.org/CodeSystem/manufacturing-step"/>
              <code value="particleSizeReduction"/>
              <display value="Particle Size Reduction"/>
            </coding>
          </code>
          <participant>
            <typeReference>
              <extension
                         url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-manufacturing-participant-pq">
                <valueReference>
                  <!-- SubstanceDefinition/startingMaterial -->
                  <reference
                             value="SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153"/>
                </valueReference>
              </extension>
              <display value="Starting material"/>
            </typeReference>
            <role>
              <coding>
                <system
                        value="http://terminology.hl7.org/CodeSystem/manufacturing-participant-role"/>
                <code value="StartingMaterial"/>
                <display value="Starting Material"/>
              </coding>
            </role>
          </participant>
          <participant>
            <typeReference>
              <extension
                         url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-manufacturing-participant-pq">
                <valueReference>
                  <!-- SubstanceDefinition/intermediateMaterial -->
                  <reference
                             value="SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155"/>
                </valueReference>
              </extension>
              <display value="Intermediate material"/>
            </typeReference>
            <role>
              <coding>
                <system
                        value="http://terminology.hl7.org/CodeSystem/manufacturing-participant-role"/>
                <code value="IntermediateMaterial"/>
                <display value="Intermediate Material"/>
              </coding>
            </role>
          </participant>
          <participant>
            <typeReference>
              <extension
                         url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-manufacturing-participant-pq">
                <valueReference>
                  <!-- SubstanceDefinition/resultingMaterial -->
                  <reference
                             value="SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821154"/>
                </valueReference>
              </extension>
              <display value="Resulting material"/>
            </typeReference>
            <role>
              <coding>
                <system
                        value="http://terminology.hl7.org/CodeSystem/manufacturing-participant-role"/>
                <code value="ResultingMaterial"/>
                <display value="Resulting Material"/>
              </coding>
            </role>
          </participant>
          <action>
            <code>
              <text value="Test"/>
            </code>
            <!-- ObservationDefinition/Step1Yield -->
            <definitionCanonical
                                 value="http://example-server.com/fhir/ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"/>
          </action>
        </action>
        <action>
          <title value="Step 1 In-Process Control Data"/>
          <code>
            <coding>
              <system
                      value="http://terminology.hl7.org/CodeSystem/manufacturing-step"/>
              <code value="Step1In-ProcessControlData"/>
              <display value="Step 1 In-Process Control Data"/>
            </coding>
          </code>
          <action>
            <code>
              <text value="Test"/>
            </code>
            <!-- ObservationDefinition/ResidualWaterContent -->
            <definitionCanonical
                                 value="http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"/>
          </action>
          <action>
            <code>
              <text value="Test"/>
            </code>
            <!-- ObservationDefinition/ResidualStartingMaterial1byHPLC -->
            <definitionCanonical
                                 value="http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9ff1-91c2-2d16-57cb5b295e72"/>
          </action>
        </action>
        <action>
          <title value="Step 1 DS Release Testing Results"/>
          <code>
            <coding>
              <system
                      value="http://terminology.hl7.org/CodeSystem/manufacturing-step"/>
              <code value="Step1DSReleaseTestingResults"/>
              <display value="Step 1 DS Release Testing Results"/>
            </coding>
          </code>
          <action>
            <code>
              <text value="Test"/>
            </code>
            <!-- ObservationDefinition/AppearanceSubstance -->
            <definitionCanonical
                                 value="http://example-server.com/fhir/ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"/>
          </action>
          <action>
            <code>
              <text value="Test"/>
            </code>
            <!-- ObservationDefinition/IdentificationSubstance -->
            <definitionCanonical
                                 value="http://example-server.com/fhir/ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d"/>
          </action>
          <action>
            <code>
              <text value="Test"/>
            </code>
            <!-- ObservationDefinition/AssaySubstance -->
            <definitionCanonical
                                 value="http://example-server.com/fhir/ObservationDefinition/12e7e672-40a6-4036-3c1f-b8ba6a7d045e"/>
          </action>
        </action>
        <action>
          <extension
                     url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-process-step-scale-pq">
            <valueCoding>
              <system
                      value="http://terminology.hl7.org/CodeSystem/manufacturing-step-scale"/>
              <code value="PROD"/>
              <display value="Production Scale"/>
            </valueCoding>
          </extension>
          <prefix value="2"/>
          <title value="Step 2 Yield"/>
          <description value="Description of this step"/>
          <!-- text value="Step 2 in the process - free text is possible"/ -->
          <code>
            <coding>
              <system
                      value="http://terminology.hl7.org/CodeSystem/manufacturing-step"/>
              <code value="drying"/>
              <display value="Drying"/>
            </coding>
          </code>
          <participant>
            <typeReference>
              <extension
                         url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-manufacturing-participant-pq">
                <valueReference>
                  <!-- SubstanceDefinition/startingMaterialStep2 -->
                  <reference
                             value="SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153"/>
                </valueReference>
              </extension>
              <display value="Starting material"/>
            </typeReference>
            <role>
              <coding>
                <system
                        value="http://terminology.hl7.org/CodeSystem/manufacturing-participant-role"/>
                <code value="StartingMaterial"/>
                <display value="Starting Material"/>
              </coding>
            </role>
          </participant>
          <participant>
            <typeReference>
              <extension
                         url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-manufacturing-participant-pq">
                <valueReference>
                  <!-- SubstanceDefinition/intermediateMaterialStep2 -->
                  <reference
                             value="SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155"/>
                </valueReference>
              </extension>
              <display value="Intermediate material"/>
            </typeReference>
            <role>
              <coding>
                <system
                        value="http://terminology.hl7.org/CodeSystem/manufacturing-participant-role"/>
                <code value="IntermediateMaterial"/>
                <display value="Intermediate Material"/>
              </coding>
            </role>
          </participant>
          <participant>
            <typeReference>
              <extension
                         url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-manufacturing-participant-pq">
                <valueReference>
                  <!-- SubstanceDefinition/resultingMaterialStep2 -->
                  <reference
                             value="SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821154"/>
                </valueReference>
              </extension>
              <display value="Resulting material"/>
            </typeReference>
            <role>
              <coding>
                <system
                        value="http://terminology.hl7.org/CodeSystem/manufacturing-participant-role"/>
                <code value="ResultingMaterial"/>
                <display value="Resulting Material"/>
              </coding>
            </role>
          </participant>
          <action>
            <code>
              <text value="Test"/>
            </code>
            <!-- ObservationDefinition/Step2Yield -->
            <definitionCanonical
                                 value="http://example-server.com/fhir/ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"/>
          </action>
        </action>
      </PlanDefinition>
    </resource>
  </entry>
  <!--  Diagnostic report doesn't carry much extra value but does collect all the observations  -->
  <entry>
    <fullUrl value="urn:uuid:b664977d-799d-a1ce-928a-5def2a9955bd"/>
    <resource>
      <DiagnosticReport>
        <!--  ideally this wants a subject, but it can only be a Medication (batch) and we have multiple. 
                     however the observations themselves do have subjects  -->
        <id value="processValidationReport"/>
        <text>
          <status value="extensions"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="DiagnosticReport_processValidationReport"> </a><p><b>Generated Narrative: DiagnosticReport</b><a name="processValidationReport"> </a><a name="hcprocessValidationReport"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource DiagnosticReport &quot;processValidationReport&quot; </p></div><p><b>Triggered by</b>: See on this page: PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f</p><p><b>status</b>: final</p><p><b>code</b>: Process Validation Report <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-pharmaceutical-report-type.html">Pharmaceutical Report Type Codes</a>#Process Validation Report)</span></p><p><b>effective</b>: 2020-12</p><p><b>result</b>: </p><ul><li>See on this page: Observation/9c56948c-2a39-6609-1c01-4d197ea57a33</li><li>See on this page: Observation/9c56948a-2b39-6609-1c01-4d197ea57a33</li><li>See on this page: Observation/9c56948a-2a39-6609-1c01-4d197ea57a33</li><li>See on this page: Observation/9c56958c-2a39-6609-1c01-4d197ea57a33</li><li>See on this page: Observation/9c56968a-2b39-6609-1c01-4d197ea57a33</li><li>See on this page: Observation/9c56978a-2a39-6609-1c01-4d197ea57a33</li><li>See on this page: Observation/9c56948c-2a39-6609-2c01-4d197ea57a33</li><li>See on this page: Observation/9c56948c-2a49-6609-2c01-4d197ea57a33</li><li>See on this page: Observation/9c56948c-2a39-6609-2c01-4d197eb57a33</li><li>See on this page: Observation/9c56958c-2a39-6609-2c01-4d197ea57a33</li><li>See on this page: Observation/9c56968c-2a49-6609-2c01-4d197ea57a33</li><li>See on this page: Observation/9c56978c-2a39-6609-2c01-4d197eb57a33</li><li>See on this page: Observation/9c56948d-2a39-6609-1c01-4d197ea57a33</li><li>See on this page: Observation/9c56948c-2b39-6609-1c01-4d197ea57a33</li><li>See on this page: Observation/9c56948b-2a39-6609-1c01-4d197ea57a33</li></ul><p><b>conclusion</b>: The samples have been assessed and the conclusion is...</p></div>
        </text>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/workflow-triggeredBy">
          <valueReference>
            <!-- PlanDefinition/validationProtocol -->
            <reference
                       value="PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f"/>
          </valueReference>
        </extension>
        <status value="final"/>
        <code>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/pharmaceutical-report-type"/>
            <code value="Process Validation Report"/>
            <display value="Process Validation Report"/>
          </coding>
        </code>
        <effectiveDateTime value="2020-12"/>
        <result>
          <!-- Observation/step1Yield1 -->
          <reference
                     value="Observation/9c56948c-2a39-6609-1c01-4d197ea57a33"/>
        </result>
        <result>
          <!-- Observation/step1Yield2 -->
          <reference
                     value="Observation/9c56948a-2b39-6609-1c01-4d197ea57a33"/>
        </result>
        <result>
          <!-- Observation/step1Yield3 -->
          <reference
                     value="Observation/9c56948a-2a39-6609-1c01-4d197ea57a33"/>
        </result>
        <result>
          <!-- Observation/residualWaterContent1 -->
          <reference
                     value="Observation/9c56958c-2a39-6609-1c01-4d197ea57a33"/>
        </result>
        <result>
          <!-- Observation/residualWaterContent2 -->
          <reference
                     value="Observation/9c56968a-2b39-6609-1c01-4d197ea57a33"/>
        </result>
        <result>
          <!-- Observation/residualWaterContent3 -->
          <reference
                     value="Observation/9c56978a-2a39-6609-1c01-4d197ea57a33"/>
        </result>
        <result>
          <!-- Observation/appearanceSubstance1 -->
          <reference
                     value="Observation/9c56948c-2a39-6609-2c01-4d197ea57a33"/>
        </result>
        <result>
          <!-- Observation/appearanceSubstance2 -->
          <reference
                     value="Observation/9c56948c-2a49-6609-2c01-4d197ea57a33"/>
        </result>
        <result>
          <!-- Observation/appearanceSubstance3 -->
          <reference
                     value="Observation/9c56948c-2a39-6609-2c01-4d197eb57a33"/>
        </result>
        <result>
          <!-- Observation/identificationSubstance1 -->
          <reference
                     value="Observation/9c56958c-2a39-6609-2c01-4d197ea57a33"/>
        </result>
        <result>
          <!-- Observation/identificationSubstance2 -->
          <reference
                     value="Observation/9c56968c-2a49-6609-2c01-4d197ea57a33"/>
        </result>
        <result>
          <!-- Observation/identificationSubstance3 -->
          <reference
                     value="Observation/9c56978c-2a39-6609-2c01-4d197eb57a33"/>
        </result>
        <result>
          <!-- Observation/step2Yield1 -->
          <reference
                     value="Observation/9c56948d-2a39-6609-1c01-4d197ea57a33"/>
        </result>
        <result>
          <!-- Observation/step2Yield2 -->
          <reference
                     value="Observation/9c56948c-2b39-6609-1c01-4d197ea57a33"/>
        </result>
        <result>
          <!-- Observation/step2Yield3 -->
          <reference
                     value="Observation/9c56948b-2a39-6609-1c01-4d197ea57a33"/>
        </result>
        <conclusion
                    value="The samples have been assessed and the conclusion is..."/>
      </DiagnosticReport>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"/>
    <resource>
      <ObservationDefinition>
        <!-- AppearanceSubstance -->
        <id value="fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="ObservationDefinition_fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"> </a><p><b>Generated Narrative: ObservationDefinition</b><a name="fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"> </a><a name="hcfc07b5d5-9fe1-92c2-2d06-57cb5b295e72"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ObservationDefinition &quot;fc07b5d5-9fe1-92c2-2d06-57cb5b295e72&quot; </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72</code></p><p><b>title</b>: Appearance</p><p><b>status</b>: active</p><p><b>code</b>: Appearance <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Appearance)</span></p><p><b>method</b>: Visual inspection <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><h3>QualifiedValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Extension</b></td></tr><tr><td style="display: none">*</td><td/></tr></table></div>
        </text>
        <!-- http://example-server.com/fhir/ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72 -->
        <url
             value="http://example-server.com/fhir/ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"/>
        <title value="Appearance"/>
        <status value="active"/>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
            <code value="Appearance"/>
            <display value="Appearance"/>
          </coding>
          <text value="Appearance"/>
        </code>
        <method>
          <text value="Visual inspection"/>
        </method>
        <qualifiedValue>
          <extension
                     url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-qualified-value-text-pq">
            <valueString
                         value="White to off-white, to red, to orange, to brown solid"/>
          </extension>
        </qualifiedValue>
      </ObservationDefinition>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:3b1e878e-4bc9-8864-862f-e28b21233e8d"/>
    <resource>
      <ObservationDefinition>
        <!-- IdentificationSubstance -->
        <id value="3b1e878e-4bc9-8864-862f-e28b21233e8d"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="ObservationDefinition_3b1e878e-4bc9-8864-862f-e28b21233e8d"> </a><p><b>Generated Narrative: ObservationDefinition</b><a name="3b1e878e-4bc9-8864-862f-e28b21233e8d"> </a><a name="hc3b1e878e-4bc9-8864-862f-e28b21233e8d"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ObservationDefinition &quot;3b1e878e-4bc9-8864-862f-e28b21233e8d&quot; </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d</code></p><p><b>title</b>: ID by HPLC</p><p><b>status</b>: active</p><p><b>code</b>: ID by HPLC <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#IDT &quot;Identification&quot;)</span></p><p><b>method</b>: ID by UHPLC <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><h3>QualifiedValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Extension</b></td></tr><tr><td style="display: none">*</td><td/></tr></table></div>
        </text>
        <!-- http://example-server.com/fhir/ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d -->
        <url
             value="http://example-server.com/fhir/ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d"/>
        <title value="ID by HPLC"/>
        <status value="active"/>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
            <code value="IDT"/>
            <display value="Identification"/>
          </coding>
          <text value="ID by HPLC"/>
        </code>
        <method>
          <text value="ID by UHPLC"/>
        </method>
        <qualifiedValue>
          <extension
                     url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-qualified-value-text-pq">
            <valueString value="Conforms to standard"/>
          </extension>
        </qualifiedValue>
      </ObservationDefinition>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:12e7e672-40a6-4036-3c1f-b8ba6a7d045e"/>
    <resource>
      <ObservationDefinition>
        <!-- AssaySubstance -->
        <id value="12e7e672-40a6-4036-3c1f-b8ba6a7d045e"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="ObservationDefinition_12e7e672-40a6-4036-3c1f-b8ba6a7d045e"> </a><p><b>Generated Narrative: ObservationDefinition</b><a name="12e7e672-40a6-4036-3c1f-b8ba6a7d045e"> </a><a name="hc12e7e672-40a6-4036-3c1f-b8ba6a7d045e"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ObservationDefinition &quot;12e7e672-40a6-4036-3c1f-b8ba6a7d045e&quot; </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/12e7e672-40a6-4036-3c1f-b8ba6a7d045e</code></p><p><b>title</b>: Assay by HPLC (as is) (w/w%)</p><p><b>status</b>: active</p><p><b>code</b>: Assay by HPLC (as is) (w/w%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#ASSAY &quot;Assay&quot;)</span></p><p><b>method</b>: Assay by UHPLC <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><h3>QualifiedValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Range</b></td></tr><tr><td style="display: none">*</td><td>95-101 %</td></tr></table></div>
        </text>
        <!-- http://example-server.com/fhir/ObservationDefinition/12e7e672-40a6-4036-3c1f-b8ba6a7d045e -->
        <url
             value="http://example-server.com/fhir/ObservationDefinition/12e7e672-40a6-4036-3c1f-b8ba6a7d045e"/>
        <title value="Assay by HPLC (as is) (w/w%)"/>
        <status value="active"/>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
            <code value="ASSAY"/>
            <display value="Assay"/>
          </coding>
          <text value="Assay by HPLC (as is) (w/w%)"/>
        </code>
        <method>
          <text value="Assay by UHPLC"/>
        </method>
        <qualifiedValue>
          <range>
            <low>
              <value value="95"/>
              <unit value="%"/>
              <system value="http://unitsofmeasure.org"/>
              <code value="%"/>
            </low>
            <high>
              <value value="101"/>
              <unit value="%"/>
              <system value="http://unitsofmeasure.org"/>
              <code value="%"/>
            </high>
          </range>
        </qualifiedValue>
      </ObservationDefinition>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"/>
    <resource>
      <ObservationDefinition>
        <!-- Step1Yield -->
        <id value="fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="ObservationDefinition_fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"> </a><p><b>Generated Narrative: ObservationDefinition</b><a name="fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"> </a><a name="hcfd17b5d6-9fe1-91c2-2d06-47cb5b295e72"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ObservationDefinition &quot;fd17b5d6-9fe1-91c2-2d06-47cb5b295e72&quot; </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72</code></p><p><b>title</b>: Yield (%)</p><p><b>status</b>: active</p><p><b>code</b>: Yield (%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Yield (%))</span></p></div>
        </text>
        <!-- http://example-server.com/fhir/ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72 -->
        <url
             value="http://example-server.com/fhir/ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"/>
        <title value="Yield (%)"/>
        <status value="active"/>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
            <code value="Yield (%)"/>
            <display value="Yield (%)"/>
          </coding>
          <text value="Yield (%)"/>
        </code>
      </ObservationDefinition>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"/>
    <resource>
      <ObservationDefinition>
        <!-- Step2Yield -->
        <id value="fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="ObservationDefinition_fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"> </a><p><b>Generated Narrative: ObservationDefinition</b><a name="fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"> </a><a name="hcfd17b5d7-9fe1-91c2-2d06-47cb5b295e72"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ObservationDefinition &quot;fd17b5d7-9fe1-91c2-2d06-47cb5b295e72&quot; </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72</code></p><p><b>title</b>: Yield (%)</p><p><b>status</b>: active</p><p><b>code</b>: Yield (%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Yield (%))</span></p></div>
        </text>
        <!-- http://example-server.com/fhir/ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72 -->
        <url
             value="http://example-server.com/fhir/ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"/>
        <title value="Yield (%)"/>
        <status value="active"/>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
            <code value="Yield (%)"/>
            <display value="Yield (%)"/>
          </coding>
          <text value="Yield (%)"/>
        </code>
      </ObservationDefinition>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"/>
    <resource>
      <ObservationDefinition>
        <!-- ResidualWaterContent -->
        <id value="fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="ObservationDefinition_fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"> </a><p><b>Generated Narrative: ObservationDefinition</b><a name="fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"> </a><a name="hcfc27b5d6-9fe1-91c2-2d16-57cb5b295e72"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ObservationDefinition &quot;fc27b5d6-9fe1-91c2-2d16-57cb5b295e72&quot; </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72</code></p><p><b>title</b>: Residual Water Content (w/w%)</p><p><b>status</b>: active</p><p><b>code</b>: Residual Water Content (w/w%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#ResidualWaterContent)</span></p><h3>QualifiedValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Extension</b></td><td><b>Range</b></td></tr><tr><td style="display: none">*</td><td/><td>?-7.15</td></tr></table></div>
        </text>
        <!-- http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72 -->
        <url
             value="http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"/>
        <title value="Residual Water Content (w/w%)"/>
        <status value="active"/>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
            <code value="ResidualWaterContent"/>
            <display value="Residual Water Content (w/w%)"/>
          </coding>
          <text value="Residual Water Content (w/w%)"/>
        </code>
        <qualifiedValue>
          <extension
                     url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-qualified-value-criticality-pq">
            <valueCodeableConcept>
              <coding>
                <system
                        value="http://terminology.hl7.org/CodeSystem/observation-qualified-value-criticality"/>
                <code value="Non-critical"/>
                <display value="Non-critical"/>
              </coding>
              <text value="Non-critical"/>
            </valueCodeableConcept>
          </extension>
          <range>
            <high>
              <value value="7.15"/>
              <unit value="%"/>
              <system value="http://unitsofmeasure.org"/>
              <code value="%"/>
            </high>
          </range>
        </qualifiedValue>
      </ObservationDefinition>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:fc27b5d6-9ff1-91c2-2d16-57cb5b295e72"/>
    <resource>
      <ObservationDefinition>
        <!-- ResidualStartingMaterial1byHPLC -->
        <id value="fc27b5d6-9ff1-91c2-2d16-57cb5b295e72"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="ObservationDefinition_fc27b5d6-9ff1-91c2-2d16-57cb5b295e72"> </a><p><b>Generated Narrative: ObservationDefinition</b><a name="fc27b5d6-9ff1-91c2-2d16-57cb5b295e72"> </a><a name="hcfc27b5d6-9ff1-91c2-2d16-57cb5b295e72"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ObservationDefinition &quot;fc27b5d6-9ff1-91c2-2d16-57cb5b295e72&quot; </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9ff1-91c2-2d16-57cb5b295e72</code></p><p><b>title</b>: Reaction conversion: residual starting material 1 by HPLC (Step Aa) (LC area %)</p><p><b>status</b>: active</p><p><b>code</b>: Reaction conversion: Residual Starting Material 1 by HPLC <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Reaction conversion: Residual Starting Material 1 by HPLC)</span></p><h3>QualifiedValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Extension</b></td><td><b>Range</b></td></tr><tr><td style="display: none">*</td><td/><td>?-23</td></tr></table></div>
        </text>
        <!-- http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9ff1-91c2-2d16-57cb5b295e72 -->
        <url
             value="http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9ff1-91c2-2d16-57cb5b295e72"/>
        <title
               value="Reaction conversion: residual starting material 1 by HPLC (Step Aa) (LC area %)"/>
        <status value="active"/>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
            <code
                  value="Reaction conversion: Residual Starting Material 1 by HPLC"/>
            <display
                     value="Reaction conversion: Residual Starting Material 1 by HPLC"/>
          </coding>
          <text
                value="Reaction conversion: Residual Starting Material 1 by HPLC"/>
        </code>
        <qualifiedValue>
          <extension
                     url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-qualified-value-criticality-pq">
            <valueCodeableConcept>
              <coding>
                <system
                        value="http://terminology.hl7.org/CodeSystem/observation-qualified-value-criticality"/>
                <code value="critical"/>
                <display value="Critical"/>
              </coding>
              <text value="Critical"/>
            </valueCodeableConcept>
          </extension>
          <range>
            <high>
              <value value="23"/>
              <unit value="%"/>
              <system value="http://unitsofmeasure.org"/>
              <code value="%"/>
            </high>
          </range>
        </qualifiedValue>
      </ObservationDefinition>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:9c56948c-2a39-6609-2c01-4d197ea57a33"/>
    <resource>
      <Observation>
        <!-- appearanceSubstance1 -->
        <id value="9c56948c-2a39-6609-2c01-4d197ea57a33"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_9c56948c-2a39-6609-2c01-4d197ea57a33"> </a><p><b>Generated Narrative: Observation</b><a name="9c56948c-2a39-6609-2c01-4d197ea57a33"> </a><a name="hc9c56948c-2a39-6609-2c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;9c56948c-2a39-6609-2c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: Appearance <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Appearance)</span></p><p><b>subject</b>: See on this page: Substance/fc178763-81c5-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: Off-white solid</p></div>
        </text>
        <instantiatesReference>
          <!-- ObservationDefinition/AppearanceSubstance -->
          <reference
                     value="ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"/>
        </instantiatesReference>
        <status value="final"/>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
            <code value="Appearance"/>
            <display value="Appearance"/>
          </coding>
          <text value="Appearance"/>
        </code>
        <subject>
          <!-- Substance/actual-batch-substance-itermediate-1 -->
          <reference value="Substance/fc178763-81c5-5656-9744-13c7ad1e595b"/>
        </subject>
        <effectiveDateTime value="2023-01-01T12:00:00Z"/>
        <performer>
          <!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
          <reference
                     value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
        </performer>
        <valueString value="Off-white solid"/>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:9c56948c-2a49-6609-2c01-4d197ea57a33"/>
    <resource>
      <Observation>
        <!-- appearanceSubstance2 -->
        <id value="9c56948c-2a49-6609-2c01-4d197ea57a33"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_9c56948c-2a49-6609-2c01-4d197ea57a33"> </a><p><b>Generated Narrative: Observation</b><a name="9c56948c-2a49-6609-2c01-4d197ea57a33"> </a><a name="hc9c56948c-2a49-6609-2c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;9c56948c-2a49-6609-2c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: Appearance <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Appearance)</span></p><p><b>subject</b>: See on this page: Substance/fc178764-81d5-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: Off-white solid</p></div>
        </text>
        <instantiatesReference>
          <!-- ObservationDefinition/AppearanceSubstance -->
          <reference
                     value="ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"/>
        </instantiatesReference>
        <status value="final"/>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
            <code value="Appearance"/>
            <display value="Appearance"/>
          </coding>
          <text value="Appearance"/>
        </code>
        <subject>
          <!-- Substance/actual-batch-substance-itermediate-2 -->
          <reference value="Substance/fc178764-81d5-5656-9744-13c7ad1e595b"/>
        </subject>
        <effectiveDateTime value="2023-01-01T12:00:00Z"/>
        <performer>
          <!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
          <reference
                     value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
        </performer>
        <valueString value="Off-white solid"/>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:9c56948c-2a39-6609-2c01-4d197eb57a33"/>
    <resource>
      <Observation>
        <!-- appearanceSubstance3 -->
        <id value="9c56948c-2a39-6609-2c01-4d197eb57a33"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_9c56948c-2a39-6609-2c01-4d197eb57a33"> </a><p><b>Generated Narrative: Observation</b><a name="9c56948c-2a39-6609-2c01-4d197eb57a33"> </a><a name="hc9c56948c-2a39-6609-2c01-4d197eb57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;9c56948c-2a39-6609-2c01-4d197eb57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: Appearance <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Appearance)</span></p><p><b>subject</b>: See on this page: Substance/fc178764-81d6-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: Off-white solid</p></div>
        </text>
        <instantiatesReference>
          <!-- ObservationDefinition/AppearanceSubstance -->
          <reference
                     value="ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"/>
        </instantiatesReference>
        <status value="final"/>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
            <code value="Appearance"/>
            <display value="Appearance"/>
          </coding>
          <text value="Appearance"/>
        </code>
        <subject>
          <!-- Substance/actual-batch-substance-itermediate-3 -->
          <reference value="Substance/fc178764-81d6-5656-9744-13c7ad1e595b"/>
        </subject>
        <effectiveDateTime value="2023-01-01T12:00:00Z"/>
        <performer>
          <!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
          <reference
                     value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
        </performer>
        <valueString value="Off-white solid"/>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:9c56958c-2a39-6609-2c01-4d197ea57a33"/>
    <resource>
      <Observation>
        <!-- identificationSubstance1 -->
        <id value="9c56958c-2a39-6609-2c01-4d197ea57a33"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_9c56958c-2a39-6609-2c01-4d197ea57a33"> </a><p><b>Generated Narrative: Observation</b><a name="9c56958c-2a39-6609-2c01-4d197ea57a33"> </a><a name="hc9c56958c-2a39-6609-2c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;9c56958c-2a39-6609-2c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d</p><p><b>status</b>: final</p><p><b>code</b>: ID by HPLC <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#IDT &quot;Identification&quot;)</span></p><p><b>subject</b>: See on this page: Substance/fc178763-81c5-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: Conforms</p></div>
        </text>
        <instantiatesReference>
          <!-- ObservationDefinition/IdentificationSubstance -->
          <reference
                     value="ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d"/>
        </instantiatesReference>
        <status value="final"/>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
            <code value="IDT"/>
            <display value="Identification"/>
          </coding>
          <text value="ID by HPLC"/>
        </code>
        <subject>
          <!-- Substance/actual-batch-substance-itermediate-1 -->
          <reference value="Substance/fc178763-81c5-5656-9744-13c7ad1e595b"/>
        </subject>
        <effectiveDateTime value="2023-01-01T12:00:00Z"/>
        <performer>
          <!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
          <reference
                     value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
        </performer>
        <valueString value="Conforms"/>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:9c56968c-2a49-6609-2c01-4d197ea57a33"/>
    <resource>
      <Observation>
        <!-- identificationSubstance2 -->
        <id value="9c56968c-2a49-6609-2c01-4d197ea57a33"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_9c56968c-2a49-6609-2c01-4d197ea57a33"> </a><p><b>Generated Narrative: Observation</b><a name="9c56968c-2a49-6609-2c01-4d197ea57a33"> </a><a name="hc9c56968c-2a49-6609-2c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;9c56968c-2a49-6609-2c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d</p><p><b>status</b>: final</p><p><b>code</b>: ID by HPLC <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#IDT &quot;Identification&quot;)</span></p><p><b>subject</b>: See on this page: Substance/fc178764-81d5-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: Conforms</p></div>
        </text>
        <instantiatesReference>
          <!-- ObservationDefinition/IdentificationSubstance -->
          <reference
                     value="ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d"/>
        </instantiatesReference>
        <status value="final"/>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
            <code value="IDT"/>
            <display value="Identification"/>
          </coding>
          <text value="ID by HPLC"/>
        </code>
        <subject>
          <!-- Substance/actual-batch-substance-itermediate-2 -->
          <reference value="Substance/fc178764-81d5-5656-9744-13c7ad1e595b"/>
        </subject>
        <effectiveDateTime value="2023-01-01T12:00:00Z"/>
        <performer>
          <!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
          <reference
                     value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
        </performer>
        <valueString value="Conforms"/>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:9c56978c-2a39-6609-2c01-4d197eb57a33"/>
    <resource>
      <Observation>
        <!-- identificationSubstance3 -->
        <id value="9c56978c-2a39-6609-2c01-4d197eb57a33"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_9c56978c-2a39-6609-2c01-4d197eb57a33"> </a><p><b>Generated Narrative: Observation</b><a name="9c56978c-2a39-6609-2c01-4d197eb57a33"> </a><a name="hc9c56978c-2a39-6609-2c01-4d197eb57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;9c56978c-2a39-6609-2c01-4d197eb57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d</p><p><b>status</b>: final</p><p><b>code</b>: ID by HPLC <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#IDT &quot;Identification&quot;)</span></p><p><b>subject</b>: See on this page: Substance/fc178764-81d6-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: Does not conform</p></div>
        </text>
        <instantiatesReference>
          <!-- ObservationDefinition/IdentificationSubstance -->
          <reference
                     value="ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d"/>
        </instantiatesReference>
        <status value="final"/>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
            <code value="IDT"/>
            <display value="Identification"/>
          </coding>
          <text value="ID by HPLC"/>
        </code>
        <subject>
          <!-- Substance/actual-batch-substance-itermediate-3 -->
          <reference value="Substance/fc178764-81d6-5656-9744-13c7ad1e595b"/>
        </subject>
        <effectiveDateTime value="2023-01-01T12:00:00Z"/>
        <performer>
          <!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
          <reference
                     value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
        </performer>
        <valueString value="Does not conform"/>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:9c56948c-2a39-6609-1c01-4d197ea57a33"/>
    <resource>
      <Observation>
        <!-- step1Yield1 -->
        <id value="9c56948c-2a39-6609-1c01-4d197ea57a33"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_9c56948c-2a39-6609-1c01-4d197ea57a33"> </a><p><b>Generated Narrative: Observation</b><a name="9c56948c-2a39-6609-1c01-4d197ea57a33"> </a><a name="hc9c56948c-2a39-6609-1c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;9c56948c-2a39-6609-1c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: Yield (%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Yield (%))</span></p><p><b>subject</b>: See on this page: Substance/fc178763-81c5-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 75 %</p></div>
        </text>
        <instantiatesReference>
          <!-- ObservationDefinition/Step1Yield -->
          <reference
                     value="ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"/>
        </instantiatesReference>
        <status value="final"/>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
            <code value="Yield (%)"/>
            <display value="Yield (%)"/>
          </coding>
          <text value="Yield (%)"/>
        </code>
        <subject>
          <!-- Substance/actual-batch-substance-itermediate-1 -->
          <reference value="Substance/fc178763-81c5-5656-9744-13c7ad1e595b"/>
        </subject>
        <effectiveDateTime value="2023-01-01T12:00:00Z"/>
        <performer>
          <!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
          <reference
                     value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
        </performer>
        <valueQuantity>
          <value value="75"/>
          <unit value="%"/>
        </valueQuantity>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:9c56948a-2b39-6609-1c01-4d197ea57a33"/>
    <resource>
      <Observation>
        <!-- step1Yield2 -->
        <id value="9c56948a-2b39-6609-1c01-4d197ea57a33"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_9c56948a-2b39-6609-1c01-4d197ea57a33"> </a><p><b>Generated Narrative: Observation</b><a name="9c56948a-2b39-6609-1c01-4d197ea57a33"> </a><a name="hc9c56948a-2b39-6609-1c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;9c56948a-2b39-6609-1c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: Yield (%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Yield (%))</span></p><p><b>subject</b>: See on this page: Substance/fc178764-81d5-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 77 %</p></div>
        </text>
        <instantiatesReference>
          <!-- ObservationDefinition/Step1Yield -->
          <reference
                     value="ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"/>
        </instantiatesReference>
        <status value="final"/>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
            <code value="Yield (%)"/>
            <display value="Yield (%)"/>
          </coding>
          <text value="Yield (%)"/>
        </code>
        <subject>
          <!-- Substance/actual-batch-substance-itermediate-2 -->
          <reference value="Substance/fc178764-81d5-5656-9744-13c7ad1e595b"/>
        </subject>
        <effectiveDateTime value="2023-01-01T12:00:00Z"/>
        <performer>
          <!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
          <reference
                     value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
        </performer>
        <valueQuantity>
          <value value="77"/>
          <unit value="%"/>
        </valueQuantity>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:9c56948a-2a39-6609-1c01-4d197ea57a33"/>
    <resource>
      <Observation>
        <!-- step1Yield3 -->
        <id value="9c56948a-2a39-6609-1c01-4d197ea57a33"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_9c56948a-2a39-6609-1c01-4d197ea57a33"> </a><p><b>Generated Narrative: Observation</b><a name="9c56948a-2a39-6609-1c01-4d197ea57a33"> </a><a name="hc9c56948a-2a39-6609-1c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;9c56948a-2a39-6609-1c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: Yield (%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Yield (%))</span></p><p><b>subject</b>: See on this page: Substance/fc178764-81d6-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 76 %</p></div>
        </text>
        <instantiatesReference>
          <!-- ObservationDefinition/Step1Yield -->
          <reference
                     value="ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"/>
        </instantiatesReference>
        <status value="final"/>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
            <code value="Yield (%)"/>
            <display value="Yield (%)"/>
          </coding>
          <text value="Yield (%)"/>
        </code>
        <subject>
          <!-- Substance/actual-batch-substance-itermediate-3 -->
          <reference value="Substance/fc178764-81d6-5656-9744-13c7ad1e595b"/>
        </subject>
        <effectiveDateTime value="2023-01-01T12:00:00Z"/>
        <performer>
          <!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
          <reference
                     value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
        </performer>
        <valueQuantity>
          <value value="76"/>
          <unit value="%"/>
        </valueQuantity>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:9c56948d-2a39-6609-1c01-4d197ea57a33"/>
    <resource>
      <Observation>
        <!-- step2Yield1 -->
        <id value="9c56948d-2a39-6609-1c01-4d197ea57a33"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_9c56948d-2a39-6609-1c01-4d197ea57a33"> </a><p><b>Generated Narrative: Observation</b><a name="9c56948d-2a39-6609-1c01-4d197ea57a33"> </a><a name="hc9c56948d-2a39-6609-1c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;9c56948d-2a39-6609-1c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: Yield (%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Yield (%))</span></p><p><b>subject</b>: See on this page: Substance/fc178763-81c5-5656-9754-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 85 %</p></div>
        </text>
        <instantiatesReference>
          <!-- ObservationDefinition/Step2Yield -->
          <reference
                     value="ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"/>
        </instantiatesReference>
        <status value="final"/>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
            <code value="Yield (%)"/>
            <display value="Yield (%)"/>
          </coding>
          <text value="Yield (%)"/>
        </code>
        <subject>
          <!-- Substance/actual-batch-substance-itermediate-step2-1 -->
          <reference value="Substance/fc178763-81c5-5656-9754-13c7ad1e595b"/>
        </subject>
        <effectiveDateTime value="2023-01-01T12:00:00Z"/>
        <performer>
          <!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
          <reference
                     value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
        </performer>
        <valueQuantity>
          <value value="85"/>
          <unit value="%"/>
        </valueQuantity>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:9c56948c-2b39-6609-1c01-4d197ea57a33"/>
    <resource>
      <Observation>
        <!-- step2Yield2 -->
        <id value="9c56948c-2b39-6609-1c01-4d197ea57a33"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_9c56948c-2b39-6609-1c01-4d197ea57a33"> </a><p><b>Generated Narrative: Observation</b><a name="9c56948c-2b39-6609-1c01-4d197ea57a33"> </a><a name="hc9c56948c-2b39-6609-1c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;9c56948c-2b39-6609-1c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: Yield (%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Yield (%))</span></p><p><b>subject</b>: See on this page: Substance/fc178764-81d5-5656-9764-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 87 %</p></div>
        </text>
        <instantiatesReference>
          <!-- ObservationDefinition/Step2Yield -->
          <reference
                     value="ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"/>
        </instantiatesReference>
        <status value="final"/>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
            <code value="Yield (%)"/>
            <display value="Yield (%)"/>
          </coding>
          <text value="Yield (%)"/>
        </code>
        <subject>
          <!-- Substance/actual-batch-substance-itermediate-step2-2 -->
          <reference value="Substance/fc178764-81d5-5656-9764-13c7ad1e595b"/>
        </subject>
        <effectiveDateTime value="2023-01-01T12:00:00Z"/>
        <performer>
          <!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
          <reference
                     value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
        </performer>
        <valueQuantity>
          <value value="87"/>
          <unit value="%"/>
        </valueQuantity>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:9c56948b-2a39-6609-1c01-4d197ea57a33"/>
    <resource>
      <Observation>
        <!-- step2Yield3 -->
        <id value="9c56948b-2a39-6609-1c01-4d197ea57a33"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_9c56948b-2a39-6609-1c01-4d197ea57a33"> </a><p><b>Generated Narrative: Observation</b><a name="9c56948b-2a39-6609-1c01-4d197ea57a33"> </a><a name="hc9c56948b-2a39-6609-1c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;9c56948b-2a39-6609-1c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: Yield (%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Yield (%))</span></p><p><b>subject</b>: See on this page: Substance/fc178764-81d6-6656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 86 %</p></div>
        </text>
        <instantiatesReference>
          <!-- ObservationDefinition/Step2Yield -->
          <reference
                     value="ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"/>
        </instantiatesReference>
        <status value="final"/>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
            <code value="Yield (%)"/>
            <display value="Yield (%)"/>
          </coding>
          <text value="Yield (%)"/>
        </code>
        <subject>
          <!-- Substance/actual-batch-substance-itermediate-step2-3 -->
          <reference value="Substance/fc178764-81d6-6656-9744-13c7ad1e595b"/>
        </subject>
        <effectiveDateTime value="2023-01-01T12:00:00Z"/>
        <performer>
          <!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
          <reference
                     value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
        </performer>
        <valueQuantity>
          <value value="86"/>
          <unit value="%"/>
        </valueQuantity>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:9c56958c-2a39-6609-1c01-4d197ea57a33"/>
    <resource>
      <Observation>
        <!-- residualWaterContent1 -->
        <id value="9c56958c-2a39-6609-1c01-4d197ea57a33"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_9c56958c-2a39-6609-1c01-4d197ea57a33"> </a><p><b>Generated Narrative: Observation</b><a name="9c56958c-2a39-6609-1c01-4d197ea57a33"> </a><a name="hc9c56958c-2a39-6609-1c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;9c56958c-2a39-6609-1c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: ResidualWaterContent (w/w%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#ResidualWaterContent &quot;Residual Water Content (w/w%)&quot;)</span></p><p><b>subject</b>: See on this page: Substance/fc178763-81c5-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 6.9 %</p></div>
        </text>
        <instantiatesReference>
          <!-- ObservationDefinition/ResidualWaterContent -->
          <reference
                     value="ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"/>
        </instantiatesReference>
        <status value="final"/>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
            <code value="ResidualWaterContent"/>
            <display value="Residual Water Content (w/w%)"/>
          </coding>
          <text value="ResidualWaterContent (w/w%)"/>
        </code>
        <subject>
          <!-- Substance/actual-batch-substance-itermediate-1 -->
          <reference value="Substance/fc178763-81c5-5656-9744-13c7ad1e595b"/>
        </subject>
        <effectiveDateTime value="2023-01-01T12:00:00Z"/>
        <performer>
          <!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
          <reference
                     value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
        </performer>
        <valueQuantity>
          <value value="6.9"/>
          <unit value="%"/>
        </valueQuantity>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:9c56968a-2b39-6609-1c01-4d197ea57a33"/>
    <resource>
      <Observation>
        <!-- residualWaterContent2 -->
        <id value="9c56968a-2b39-6609-1c01-4d197ea57a33"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_9c56968a-2b39-6609-1c01-4d197ea57a33"> </a><p><b>Generated Narrative: Observation</b><a name="9c56968a-2b39-6609-1c01-4d197ea57a33"> </a><a name="hc9c56968a-2b39-6609-1c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;9c56968a-2b39-6609-1c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: ResidualWaterContent (w/w%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#ResidualWaterContent &quot;Residual Water Content (w/w%)&quot;)</span></p><p><b>subject</b>: See on this page: Substance/fc178764-81d5-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 7.0 %</p></div>
        </text>
        <instantiatesReference>
          <!-- ObservationDefinition/ResidualWaterContent -->
          <reference
                     value="ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"/>
        </instantiatesReference>
        <status value="final"/>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
            <code value="ResidualWaterContent"/>
            <display value="Residual Water Content (w/w%)"/>
          </coding>
          <text value="ResidualWaterContent (w/w%)"/>
        </code>
        <subject>
          <!-- Substance/actual-batch-substance-itermediate-2 -->
          <reference value="Substance/fc178764-81d5-5656-9744-13c7ad1e595b"/>
        </subject>
        <effectiveDateTime value="2023-01-01T12:00:00Z"/>
        <performer>
          <!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
          <reference
                     value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
        </performer>
        <valueQuantity>
          <value value="7.0"/>
          <unit value="%"/>
        </valueQuantity>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:9c56978a-2a39-6609-1c01-4d197ea57a33"/>
    <resource>
      <Observation>
        <!-- residualWaterContent3 -->
        <id value="9c56978a-2a39-6609-1c01-4d197ea57a33"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_9c56978a-2a39-6609-1c01-4d197ea57a33"> </a><p><b>Generated Narrative: Observation</b><a name="9c56978a-2a39-6609-1c01-4d197ea57a33"> </a><a name="hc9c56978a-2a39-6609-1c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;9c56978a-2a39-6609-1c01-4d197ea57a33&quot; </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72</p><p><b>status</b>: final</p><p><b>code</b>: ResidualWaterContent (w/w%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#ResidualWaterContent &quot;Residual Water Content (w/w%)&quot;)</span></p><p><b>subject</b>: See on this page: Substance/fc178764-81d6-5656-9744-13c7ad1e595b</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 6.8 %</p></div>
        </text>
        <instantiatesReference>
          <!-- ObservationDefinition/ResidualWaterContent -->
          <reference
                     value="ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"/>
        </instantiatesReference>
        <status value="final"/>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
            <code value="ResidualWaterContent"/>
            <display value="Residual Water Content (w/w%)"/>
          </coding>
          <text value="ResidualWaterContent (w/w%)"/>
        </code>
        <subject>
          <!-- Substance/actual-batch-substance-itermediate-3 -->
          <reference value="Substance/fc178764-81d6-5656-9744-13c7ad1e595b"/>
        </subject>
        <effectiveDateTime value="2023-01-01T12:00:00Z"/>
        <performer>
          <!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
          <reference
                     value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
        </performer>
        <valueQuantity>
          <value value="6.8"/>
          <unit value="%"/>
        </valueQuantity>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:23dbbd32-2962-9fc3-40b1-67e864f21cd2"/>
    <resource>
      <Organization>
        <!-- substance-manufacturer -->
        <id value="23dbbd32-2962-9fc3-40b1-67e864f21cd2"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Organization_23dbbd32-2962-9fc3-40b1-67e864f21cd2"> </a><p><b>Generated Narrative: Organization</b><a name="23dbbd32-2962-9fc3-40b1-67e864f21cd2"> </a><a name="hc23dbbd32-2962-9fc3-40b1-67e864f21cd2"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Organization &quot;23dbbd32-2962-9fc3-40b1-67e864f21cd2&quot; </p></div><p><b>identifier</b>: <code>urn:oid:2.16.840.1.113883.4.82</code>/3003040516</p><p><b>active</b>: true</p><p><b>type</b>: Drug Substance Manufacture <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-pharmaceutical-organization-type.html">Pharmaceutical Organization Type Codes</a>#drug-substance-manufacture)</span></p><p><b>name</b>: AAA Molybdenum Products, Inc.</p><h3>Contacts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Address</b></td></tr><tr><td style="display: none">*</td><td>7233 W 116th Pl Ste C Broomfield Colorado 80020 USA </td></tr></table></div>
        </text>
        <identifier>
          <!--  FDA establishment identifier  -->
          <system value="urn:oid:2.16.840.1.113883.4.82"/>
          <value value="3003040516"/>
        </identifier>
        <active value="true"/>
        <type>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/pharmaceutical-organization-type"/>
            <code value="drug-substance-manufacture"/>
            <display value="Drug Substance Manufacture"/>
          </coding>
        </type>
        <name value="AAA Molybdenum Products, Inc."/>
        <contact>
          <address>
            <line value="7233 W 116th Pl"/>
            <line value="Ste C"/>
            <city value="Broomfield"/>
            <state value="Colorado"/>
            <postalCode value="80020"/>
            <country value="USA"/>
          </address>
        </contact>
      </Organization>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:378fbe5f-5926-3a5c-4c64-5428df877b08"/>
    <resource>
      <Organization>
        <!-- testing lab -->
        <!-- 378fbe5f-5926-3a5c-4c64-5428df877b08 -->
        <id value="378fbe5f-5926-3a5c-4c64-5428df877b08"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Organization_378fbe5f-5926-3a5c-4c64-5428df877b08"> </a><p><b>Generated Narrative: Organization</b><a name="378fbe5f-5926-3a5c-4c64-5428df877b08"> </a><a name="hc378fbe5f-5926-3a5c-4c64-5428df877b08"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Organization &quot;378fbe5f-5926-3a5c-4c64-5428df877b08&quot; </p></div><p><b>identifier</b>: <code>urn:oid:2.16.840.1.113883.4.82</code>/3007270600</p><p><b>active</b>: true</p><p><b>type</b>: Analytical Testing - Release <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-pharmaceutical-organization-type.html">Pharmaceutical Organization Type Codes</a>#analytical-testing-release)</span></p><p><b>name</b>: Testing Lab</p></div>
        </text>
        <identifier>
          <system value="urn:oid:2.16.840.1.113883.4.82"/>
          <value value="3007270600"/>
        </identifier>
        <active value="true"/>
        <type>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/pharmaceutical-organization-type"/>
            <code value="analytical-testing-release"/>
            <display value="Analytical Testing - Release"/>
          </coding>
        </type>
        <name value="Testing Lab"/>
      </Organization>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:57a9af63-315d-1585-a261-0e337b289390"/>
    <resource>
      <SubstanceDefinition>
        <!-- substancedefinition-component-substance-dxpq-ex1 -->
        <id value="57a9af63-315d-1585-a261-0e337b289390"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/SubstanceDefinition-component-substance-drug-pq"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="SubstanceDefinition_57a9af63-315d-1585-a261-0e337b289390"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name="57a9af63-315d-1585-a261-0e337b289390"> </a><a name="hc57a9af63-315d-1585-a261-0e337b289390"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource SubstanceDefinition &quot;57a9af63-315d-1585-a261-0e337b289390&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-SubstanceDefinition-component-substance-drug-pq.html">SubstanceDefinition - Component Substance Drug PQ</a></p></div><p><b>manufacturer</b>: See on this page: Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c</p><h3>Names</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Name</b></td></tr><tr><td style="display: none">*</td><td>Stelbatolol</td></tr></table></div>
        </text>
        <manufacturer>
          <!-- Organization/organization-dxpq-ex1 -->
          <reference
                     value="Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"/>
        </manufacturer>
        <name>
          <name value="Stelbatolol"/>
        </name>
      </SubstanceDefinition>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:c458791f-7cb8-428e-83f7-8a205f821153"/>
    <resource>
      <SubstanceDefinition>
        <!-- startingMaterial -->
        <id value="c458791f-7cb8-428e-83f7-8a205f821153"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="SubstanceDefinition_c458791f-7cb8-428e-83f7-8a205f821153"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name="c458791f-7cb8-428e-83f7-8a205f821153"> </a><a name="hcc458791f-7cb8-428e-83f7-8a205f821153"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource SubstanceDefinition &quot;c458791f-7cb8-428e-83f7-8a205f821153&quot; </p></div><p><b>manufacturer</b>: See on this page: Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2</p><h3>Names</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Name</b></td></tr><tr><td style="display: none">*</td><td>Stelbatosubstance</td></tr></table></div>
        </text>
        <manufacturer>
          <!-- Organization/substance-manufacturer -->
          <reference
                     value="Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2"/>
        </manufacturer>
        <name>
          <name value="Stelbatosubstance"/>
        </name>
      </SubstanceDefinition>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:fc178762-81c5-5656-9744-13c7ad1e595b"/>
    <resource>
      <Substance>
        <!-- actual-batch-substance-starting-1 -->
        <id value="fc178762-81c5-5656-9744-13c7ad1e595b"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
        </meta>
        <text>
          <status value="extensions"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_fc178762-81c5-5656-9744-13c7ad1e595b"> </a><p><b>Generated Narrative: Substance</b><a name="fc178762-81c5-5656-9744-13c7ad1e595b"> </a><a name="hcfc178762-81c5-5656-9744-13c7ad1e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance &quot;fc178762-81c5-5656-9744-13c7ad1e595b&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-01</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 8.1 kg</p></blockquote><p><b>identifier</b>: Start1Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153</td></tr></table></div>
        </text>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
          <extension url="manufacturingDate">
            <valueDateTime value="2019-09-01"/>
          </extension>
          <extension url="batchQuantity">
            <valueQuantity>
              <value value="8.1"/>
              <unit value="kg"/>
            </valueQuantity>
          </extension>
        </extension>
        <identifier>
          <value value="Start1Amgen"/>
        </identifier>
        <instance value="true"/>
        <code>
          <reference>
            <!-- SubstanceDefinition/startingMaterial -->
            <reference
                       value="SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153"/>
          </reference>
        </code>
      </Substance>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:fc178762-81d5-5656-9744-13c7ad1e595b"/>
    <resource>
      <Substance>
        <!-- actual-batch-substance-starting-2 -->
        <id value="fc178762-81d5-5656-9744-13c7ad1e595b"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
        </meta>
        <text>
          <status value="extensions"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_fc178762-81d5-5656-9744-13c7ad1e595b"> </a><p><b>Generated Narrative: Substance</b><a name="fc178762-81d5-5656-9744-13c7ad1e595b"> </a><a name="hcfc178762-81d5-5656-9744-13c7ad1e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance &quot;fc178762-81d5-5656-9744-13c7ad1e595b&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-01</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 8.2 kg</p></blockquote><p><b>identifier</b>: Start2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153</td></tr></table></div>
        </text>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
          <extension url="manufacturingDate">
            <valueDateTime value="2019-09-01"/>
          </extension>
          <extension url="batchQuantity">
            <valueQuantity>
              <value value="8.2"/>
              <unit value="kg"/>
            </valueQuantity>
          </extension>
        </extension>
        <identifier>
          <value value="Start2Amgen"/>
        </identifier>
        <instance value="true"/>
        <code>
          <reference>
            <!-- SubstanceDefinition/startingMaterial -->
            <reference
                       value="SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153"/>
          </reference>
        </code>
      </Substance>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:fc178762-81d5-5656-9744-23c7ad1e595b"/>
    <resource>
      <Substance>
        <!-- actual-batch-substance-starting-3 -->
        <id value="fc178762-81d5-5656-9744-23c7ad1e595b"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
        </meta>
        <text>
          <status value="extensions"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_fc178762-81d5-5656-9744-23c7ad1e595b"> </a><p><b>Generated Narrative: Substance</b><a name="fc178762-81d5-5656-9744-23c7ad1e595b"> </a><a name="hcfc178762-81d5-5656-9744-23c7ad1e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance &quot;fc178762-81d5-5656-9744-23c7ad1e595b&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-01</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 8.3 kg</p></blockquote><p><b>identifier</b>: Start3Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153</td></tr></table></div>
        </text>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
          <extension url="manufacturingDate">
            <valueDateTime value="2019-09-01"/>
          </extension>
          <extension url="batchQuantity">
            <valueQuantity>
              <value value="8.3"/>
              <unit value="kg"/>
            </valueQuantity>
          </extension>
        </extension>
        <identifier>
          <value value="Start3Amgen"/>
        </identifier>
        <instance value="true"/>
        <code>
          <reference>
            <!-- SubstanceDefinition/startingMaterial -->
            <reference
                       value="SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153"/>
          </reference>
        </code>
      </Substance>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:c458791f-7cb8-428e-83f7-8a205f821154"/>
    <resource>
      <SubstanceDefinition>
        <!-- resultingMaterial -->
        <id value="c458791f-7cb8-428e-83f7-8a205f821154"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="SubstanceDefinition_c458791f-7cb8-428e-83f7-8a205f821154"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name="c458791f-7cb8-428e-83f7-8a205f821154"> </a><a name="hcc458791f-7cb8-428e-83f7-8a205f821154"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource SubstanceDefinition &quot;c458791f-7cb8-428e-83f7-8a205f821154&quot; </p></div><h3>Names</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Name</b></td></tr><tr><td style="display: none">*</td><td>Resultothane</td></tr></table></div>
        </text>
        <name>
          <name value="Resultothane"/>
        </name>
      </SubstanceDefinition>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:c458791f-7cb8-428e-83f7-8a205f821155"/>
    <resource>
      <SubstanceDefinition>
        <!-- intermediateMaterial -->
        <id value="c458791f-7cb8-428e-83f7-8a205f821155"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="SubstanceDefinition_c458791f-7cb8-428e-83f7-8a205f821155"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name="c458791f-7cb8-428e-83f7-8a205f821155"> </a><a name="hcc458791f-7cb8-428e-83f7-8a205f821155"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource SubstanceDefinition &quot;c458791f-7cb8-428e-83f7-8a205f821155&quot; </p></div><p><b>manufacturer</b>: See on this page: Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2</p><h3>Names</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Name</b></td></tr><tr><td style="display: none">*</td><td>Processohol</td></tr></table></div>
        </text>
        <manufacturer>
          <!-- Organization/substance-manufacturer -->
          <reference
                     value="Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2"/>
        </manufacturer>
        <name>
          <name value="Processohol"/>
        </name>
      </SubstanceDefinition>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:fc178763-81c5-5656-9744-13c7ad1e595b"/>
    <resource>
      <Substance>
        <!-- actual-batch-substance-itermediate-1 -->
        <id value="fc178763-81c5-5656-9744-13c7ad1e595b"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
        </meta>
        <text>
          <status value="extensions"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_fc178763-81c5-5656-9744-13c7ad1e595b"> </a><p><b>Generated Narrative: Substance</b><a name="fc178763-81c5-5656-9744-13c7ad1e595b"> </a><a name="hcfc178763-81c5-5656-9744-13c7ad1e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance &quot;fc178763-81c5-5656-9744-13c7ad1e595b&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 9.1 kg</p></blockquote><p><b>Extension - Batch Derived From PQ</b>: See on this page: Substance/fc178762-81c5-5656-9744-13c7ad1e595b</p><p><b>identifier</b>: Intermed1Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155</td></tr></table></div>
        </text>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
          <extension url="batchQuantity">
            <valueQuantity>
              <value value="9.1"/>
              <unit value="kg"/>
            </valueQuantity>
          </extension>
        </extension>
        <!--  local extension  -->
        <extension
                   url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-derived-from-pq">
          <!--  assumes 1 to 1, could also be done via a Procedure but overkill  -->
          <valueReference>
            <!-- Substance/actual-batch-substance-starting-1 -->
            <reference
                       value="Substance/fc178762-81c5-5656-9744-13c7ad1e595b"/>
          </valueReference>
        </extension>
        <identifier>
          <value value="Intermed1Amgen"/>
        </identifier>
        <instance value="true"/>
        <code>
          <reference>
            <!-- SubstanceDefinition/intermediateMaterial -->
            <reference
                       value="SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155"/>
          </reference>
        </code>
      </Substance>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:fc178764-81d5-5656-9744-13c7ad1e595b"/>
    <resource>
      <Substance>
        <!-- actual-batch-substance-itermediate-2 -->
        <id value="fc178764-81d5-5656-9744-13c7ad1e595b"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
        </meta>
        <text>
          <status value="extensions"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_fc178764-81d5-5656-9744-13c7ad1e595b"> </a><p><b>Generated Narrative: Substance</b><a name="fc178764-81d5-5656-9744-13c7ad1e595b"> </a><a name="hcfc178764-81d5-5656-9744-13c7ad1e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance &quot;fc178764-81d5-5656-9744-13c7ad1e595b&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 9.2 kg</p></blockquote><p><b>Extension - Batch Derived From PQ</b>: See on this page: Substance/fc178762-81d5-5656-9744-13c7ad1e595b</p><p><b>identifier</b>: Intermed2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155</td></tr></table></div>
        </text>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
          <extension url="batchQuantity">
            <valueQuantity>
              <value value="9.2"/>
              <unit value="kg"/>
            </valueQuantity>
          </extension>
        </extension>
        <!--  local extension  -->
        <extension
                   url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-derived-from-pq">
          <!--  assumes 1 to 1, could also be done via a Procedure but overkill  -->
          <valueReference>
            <!-- Substance/actual-batch-substance-starting-2 -->
            <reference
                       value="Substance/fc178762-81d5-5656-9744-13c7ad1e595b"/>
          </valueReference>
        </extension>
        <identifier>
          <value value="Intermed2Amgen"/>
        </identifier>
        <instance value="true"/>
        <code>
          <reference>
            <!-- SubstanceDefinition/intermediateMaterial -->
            <reference
                       value="SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155"/>
          </reference>
        </code>
      </Substance>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:fc178764-81d6-5656-9744-13c7ad1e595b"/>
    <resource>
      <Substance>
        <!-- actual-batch-substance-itermediate-3 -->
        <id value="fc178764-81d6-5656-9744-13c7ad1e595b"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
        </meta>
        <text>
          <status value="extensions"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_fc178764-81d6-5656-9744-13c7ad1e595b"> </a><p><b>Generated Narrative: Substance</b><a name="fc178764-81d6-5656-9744-13c7ad1e595b"> </a><a name="hcfc178764-81d6-5656-9744-13c7ad1e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance &quot;fc178764-81d6-5656-9744-13c7ad1e595b&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 9.3 kg</p></blockquote><p><b>Extension - Batch Derived From PQ</b>: See on this page: Substance/fc178762-81d5-5656-9744-23c7ad1e595b</p><p><b>identifier</b>: Intermed3Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155</td></tr></table></div>
        </text>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
          <extension url="batchQuantity">
            <valueQuantity>
              <value value="9.3"/>
              <unit value="kg"/>
            </valueQuantity>
          </extension>
        </extension>
        <!--  local extension  -->
        <extension
                   url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-derived-from-pq">
          <!--  assumes 1 to 1, could also be done via a Procedure but overkill  -->
          <valueReference>
            <!-- Substance/actual-batch-substance-starting-3 -->
            <reference
                       value="Substance/fc178762-81d5-5656-9744-23c7ad1e595b"/>
          </valueReference>
        </extension>
        <identifier>
          <value value="Intermed3Amgen"/>
        </identifier>
        <instance value="true"/>
        <code>
          <reference>
            <!-- SubstanceDefinition/intermediateMaterial -->
            <reference
                       value="SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155"/>
          </reference>
        </code>
      </Substance>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:c458791f-8cb8-428e-83f7-8a205f821153"/>
    <resource>
      <SubstanceDefinition>
        <!-- startingMaterialStep2 -->
        <id value="c458791f-8cb8-428e-83f7-8a205f821153"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="SubstanceDefinition_c458791f-8cb8-428e-83f7-8a205f821153"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name="c458791f-8cb8-428e-83f7-8a205f821153"> </a><a name="hcc458791f-8cb8-428e-83f7-8a205f821153"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource SubstanceDefinition &quot;c458791f-8cb8-428e-83f7-8a205f821153&quot; </p></div><p><b>manufacturer</b>: See on this page: Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2</p><h3>Names</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Name</b></td></tr><tr><td style="display: none">*</td><td>Stelbatosubstance2</td></tr></table></div>
        </text>
        <manufacturer>
          <!-- Organization/substance-manufacturer -->
          <reference
                     value="Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2"/>
        </manufacturer>
        <name>
          <name value="Stelbatosubstance2"/>
        </name>
      </SubstanceDefinition>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:fc178762-81c5-5656-9744-13c7ad2e595b"/>
    <resource>
      <Substance>
        <!-- actual-batch-substance-starting-step2-1 -->
        <id value="fc178762-81c5-5656-9744-13c7ad2e595b"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
        </meta>
        <text>
          <status value="extensions"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_fc178762-81c5-5656-9744-13c7ad2e595b"> </a><p><b>Generated Narrative: Substance</b><a name="fc178762-81c5-5656-9744-13c7ad2e595b"> </a><a name="hcfc178762-81c5-5656-9744-13c7ad2e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance &quot;fc178762-81c5-5656-9744-13c7ad2e595b&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-02</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 7.1 kg</p></blockquote><p><b>identifier</b>: Start1Step2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153</td></tr></table></div>
        </text>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
          <extension url="manufacturingDate">
            <valueDateTime value="2019-09-02"/>
          </extension>
          <extension url="batchQuantity">
            <valueQuantity>
              <value value="7.1"/>
              <unit value="kg"/>
            </valueQuantity>
          </extension>
        </extension>
        <identifier>
          <value value="Start1Step2Amgen"/>
        </identifier>
        <instance value="true"/>
        <code>
          <reference>
            <!-- SubstanceDefinition/startingMaterialStep2 -->
            <reference
                       value="SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153"/>
          </reference>
        </code>
      </Substance>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:fc178762-81d5-5656-9744-13c7ad1e596b"/>
    <resource>
      <Substance>
        <!-- actual-batch-substance-starting-step2-2 -->
        <id value="fc178762-81d5-5656-9744-13c7ad1e596b"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
        </meta>
        <text>
          <status value="extensions"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_fc178762-81d5-5656-9744-13c7ad1e596b"> </a><p><b>Generated Narrative: Substance</b><a name="fc178762-81d5-5656-9744-13c7ad1e596b"> </a><a name="hcfc178762-81d5-5656-9744-13c7ad1e596b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance &quot;fc178762-81d5-5656-9744-13c7ad1e596b&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-02</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 7.2 kg</p></blockquote><p><b>identifier</b>: Start2Step2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153</td></tr></table></div>
        </text>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
          <extension url="manufacturingDate">
            <valueDateTime value="2019-09-02"/>
          </extension>
          <extension url="batchQuantity">
            <valueQuantity>
              <value value="7.2"/>
              <unit value="kg"/>
            </valueQuantity>
          </extension>
        </extension>
        <identifier>
          <value value="Start2Step2Amgen"/>
        </identifier>
        <instance value="true"/>
        <code>
          <reference>
            <!-- SubstanceDefinition/startingMaterialStep2 -->
            <reference
                       value="SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153"/>
          </reference>
        </code>
      </Substance>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:fc178762-81d5-5656-9744-23c7ad1e597b"/>
    <resource>
      <Substance>
        <!-- actual-batch-substance-starting-step2-3 -->
        <id value="fc178762-81d5-5656-9744-23c7ad1e597b"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
        </meta>
        <text>
          <status value="extensions"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_fc178762-81d5-5656-9744-23c7ad1e597b"> </a><p><b>Generated Narrative: Substance</b><a name="fc178762-81d5-5656-9744-23c7ad1e597b"> </a><a name="hcfc178762-81d5-5656-9744-23c7ad1e597b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance &quot;fc178762-81d5-5656-9744-23c7ad1e597b&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-02</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 7.3 kg</p></blockquote><p><b>identifier</b>: Start3Step2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153</td></tr></table></div>
        </text>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
          <extension url="manufacturingDate">
            <valueDateTime value="2019-09-02"/>
          </extension>
          <extension url="batchQuantity">
            <valueQuantity>
              <value value="7.3"/>
              <unit value="kg"/>
            </valueQuantity>
          </extension>
        </extension>
        <identifier>
          <value value="Start3Step2Amgen"/>
        </identifier>
        <instance value="true"/>
        <code>
          <reference>
            <!-- SubstanceDefinition/startingMaterialStep2 -->
            <reference
                       value="SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153"/>
          </reference>
        </code>
      </Substance>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:c458791f-7cb8-428e-84f7-8a205f821155"/>
    <resource>
      <SubstanceDefinition>
        <!-- intermediateMaterialStep2 -->
        <id value="c458791f-7cb8-428e-84f7-8a205f821155"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="SubstanceDefinition_c458791f-7cb8-428e-84f7-8a205f821155"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name="c458791f-7cb8-428e-84f7-8a205f821155"> </a><a name="hcc458791f-7cb8-428e-84f7-8a205f821155"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource SubstanceDefinition &quot;c458791f-7cb8-428e-84f7-8a205f821155&quot; </p></div><p><b>manufacturer</b>: See on this page: Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2</p><h3>Names</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Name</b></td></tr><tr><td style="display: none">*</td><td>ProcessoholStep2</td></tr></table></div>
        </text>
        <manufacturer>
          <!-- Organization/substance-manufacturer -->
          <reference
                     value="Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2"/>
        </manufacturer>
        <name>
          <name value="ProcessoholStep2"/>
        </name>
      </SubstanceDefinition>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:fc178763-81c5-5656-9754-13c7ad1e595b"/>
    <resource>
      <Substance>
        <!-- actual-batch-substance-itermediate-step2-1 -->
        <id value="fc178763-81c5-5656-9754-13c7ad1e595b"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
        </meta>
        <text>
          <status value="extensions"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_fc178763-81c5-5656-9754-13c7ad1e595b"> </a><p><b>Generated Narrative: Substance</b><a name="fc178763-81c5-5656-9754-13c7ad1e595b"> </a><a name="hcfc178763-81c5-5656-9754-13c7ad1e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance &quot;fc178763-81c5-5656-9754-13c7ad1e595b&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 10.1 kg</p></blockquote><p><b>Extension - Batch Derived From PQ</b>: See on this page: Substance/fc178762-81c5-5656-9744-13c7ad2e595b</p><p><b>identifier</b>: Intermed1Step2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155</td></tr></table></div>
        </text>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
          <extension url="batchQuantity">
            <valueQuantity>
              <value value="10.1"/>
              <unit value="kg"/>
            </valueQuantity>
          </extension>
        </extension>
        <!--  local extension  -->
        <extension
                   url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-derived-from-pq">
          <!--  assumes 1 to 1, could also be done via a Procedure but overkill  -->
          <valueReference>
            <!-- Substance/actual-batch-substance-starting-step2-1 -->
            <reference
                       value="Substance/fc178762-81c5-5656-9744-13c7ad2e595b"/>
          </valueReference>
        </extension>
        <identifier>
          <value value="Intermed1Step2Amgen"/>
        </identifier>
        <instance value="true"/>
        <code>
          <reference>
            <!-- SubstanceDefinition/intermediateMaterialStep2 -->
            <reference
                       value="SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155"/>
          </reference>
        </code>
      </Substance>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:fc178764-81d5-5656-9764-13c7ad1e595b"/>
    <resource>
      <Substance>
        <!-- actual-batch-substance-itermediate-step2-2 -->
        <id value="fc178764-81d5-5656-9764-13c7ad1e595b"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
        </meta>
        <text>
          <status value="extensions"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_fc178764-81d5-5656-9764-13c7ad1e595b"> </a><p><b>Generated Narrative: Substance</b><a name="fc178764-81d5-5656-9764-13c7ad1e595b"> </a><a name="hcfc178764-81d5-5656-9764-13c7ad1e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance &quot;fc178764-81d5-5656-9764-13c7ad1e595b&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 10.2 kg</p></blockquote><p><b>Extension - Batch Derived From PQ</b>: See on this page: Substance/fc178762-81d5-5656-9744-13c7ad1e596b</p><p><b>identifier</b>: Intermed2Step2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155</td></tr></table></div>
        </text>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
          <extension url="batchQuantity">
            <valueQuantity>
              <value value="10.2"/>
              <unit value="kg"/>
            </valueQuantity>
          </extension>
        </extension>
        <!--  local extension  -->
        <extension
                   url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-derived-from-pq">
          <!--  assumes 1 to 1, could also be done via a Procedure but overkill  -->
          <valueReference>
            <!-- Substance/actual-batch-substance-starting-step2-2 -->
            <reference
                       value="Substance/fc178762-81d5-5656-9744-13c7ad1e596b"/>
          </valueReference>
        </extension>
        <identifier>
          <value value="Intermed2Step2Amgen"/>
        </identifier>
        <instance value="true"/>
        <code>
          <reference>
            <!-- SubstanceDefinition/intermediateMaterialStep2 -->
            <reference
                       value="SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155"/>
          </reference>
        </code>
      </Substance>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:fc178764-81d6-6656-9744-13c7ad1e595b"/>
    <resource>
      <Substance>
        <!-- actual-batch-substance-itermediate-step2-3 -->
        <id value="fc178764-81d6-6656-9744-13c7ad1e595b"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
        </meta>
        <text>
          <status value="extensions"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_fc178764-81d6-6656-9744-13c7ad1e595b"> </a><p><b>Generated Narrative: Substance</b><a name="fc178764-81d6-6656-9744-13c7ad1e595b"> </a><a name="hcfc178764-81d6-6656-9744-13c7ad1e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance &quot;fc178764-81d6-6656-9744-13c7ad1e595b&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 10.3 kg</p></blockquote><p><b>Extension - Batch Derived From PQ</b>: See on this page: Substance/fc178762-81d5-5656-9744-23c7ad1e597b</p><p><b>identifier</b>: Intermed3Step2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155</td></tr></table></div>
        </text>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
          <extension url="batchQuantity">
            <valueQuantity>
              <value value="10.3"/>
              <unit value="kg"/>
            </valueQuantity>
          </extension>
        </extension>
        <!--  local extension  -->
        <extension
                   url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-derived-from-pq">
          <!--  assumes 1 to 1, could also be done via a Procedure but overkill  -->
          <valueReference>
            <!-- Substance/actual-batch-substance-starting-step2-3 -->
            <reference
                       value="Substance/fc178762-81d5-5656-9744-23c7ad1e597b"/>
          </valueReference>
        </extension>
        <identifier>
          <value value="Intermed3Step2Amgen"/>
        </identifier>
        <instance value="true"/>
        <code>
          <reference>
            <!-- SubstanceDefinition/intermediateMaterialStep2 -->
            <reference
                       value="SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155"/>
          </reference>
        </code>
      </Substance>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:c458791f-8cb8-428e-83f7-8a205f821154"/>
    <resource>
      <SubstanceDefinition>
        <!-- resultingMaterialStep2 -->
        <id value="c458791f-8cb8-428e-83f7-8a205f821154"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="SubstanceDefinition_c458791f-8cb8-428e-83f7-8a205f821154"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name="c458791f-8cb8-428e-83f7-8a205f821154"> </a><a name="hcc458791f-8cb8-428e-83f7-8a205f821154"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource SubstanceDefinition &quot;c458791f-8cb8-428e-83f7-8a205f821154&quot; </p></div><h3>Names</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Name</b></td></tr><tr><td style="display: none">*</td><td>ResultothaneStep2</td></tr></table></div>
        </text>
        <name>
          <name value="ResultothaneStep2"/>
        </name>
      </SubstanceDefinition>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:49d2f0c0-4b28-9271-8aaf-2996a8b9739c"/>
    <resource>
      <Organization>
        <!-- id value="substance-manufacturer"/ -->
        <!-- organization-dxpq-ex1 -->
        <id value="49d2f0c0-4b28-9271-8aaf-2996a8b9739c"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Organization-drug-pq"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Organization_49d2f0c0-4b28-9271-8aaf-2996a8b9739c"> </a><p><b>Generated Narrative: Organization</b><a name="49d2f0c0-4b28-9271-8aaf-2996a8b9739c"> </a><a name="hc49d2f0c0-4b28-9271-8aaf-2996a8b9739c"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Organization &quot;49d2f0c0-4b28-9271-8aaf-2996a8b9739c&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Organization-drug-pq.html">Organization - Drug PQ</a></p></div><p><b>identifier</b>: <code>urn:oid:2.16.840.1.113883.4.82</code>/3003040516</p><p><b>active</b>: true</p><p><b>type</b>: Drug Substance Manufacture <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-pharmaceutical-organization-type.html">Pharmaceutical Organization Type Codes</a>#drug-substance-manufacture)</span></p><p><b>name</b>: AAA Molybdenum Products, Inc.</p><h3>Contacts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Address</b></td></tr><tr><td style="display: none">*</td><td>7233 W 116th Pl Ste C Broomfield Colorado 80020 USA </td></tr></table></div>
        </text>
        <identifier>
          <!--  FDA establishment identifier  -->
          <system value="urn:oid:2.16.840.1.113883.4.82"/>
          <value value="3003040516"/>
        </identifier>
        <active value="true"/>
        <type>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/pharmaceutical-organization-type"/>
            <code value="drug-substance-manufacture"/>
            <display value="Drug Substance Manufacture"/>
          </coding>
        </type>
        <name value="AAA Molybdenum Products, Inc."/>
        <contact>
          <address>
            <line value="7233 W 116th Pl"/>
            <line value="Ste C"/>
            <city value="Broomfield"/>
            <state value="Colorado"/>
            <postalCode value="80020"/>
            <country value="USA"/>
          </address>
        </contact>
      </Organization>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:fc078762-81c5-5656-9744-13c7ad1e595b"/>
    <resource>
      <Substance>
        <!-- <id value="actual-batch-substance"/> -->
        <!-- substance-dxpq-ex1-unlinked -->
        <id value="fc078762-81c5-5656-9744-13c7ad1e595b"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
        </meta>
        <text>
          <status value="extensions"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_fc078762-81c5-5656-9744-13c7ad1e595b"> </a><p><b>Generated Narrative: Substance</b><a name="fc078762-81c5-5656-9744-13c7ad1e595b"> </a><a name="hcfc078762-81c5-5656-9744-13c7ad1e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance &quot;fc078762-81c5-5656-9744-13c7ad1e595b&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-07</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 5.1 kg</p><blockquote><p><b>url</b></p><code>batchUtilization</code></blockquote><p><b>value</b>: Development <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.0.0/CodeSystem-v3-nciThesaurus.html">NCI Thesaurus</a>#C133991)</span></p><blockquote><p><b>url</b></p><code>assignedManufacturer</code></blockquote><p><b>value</b>: See on this page: Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c</p></blockquote><p><b>Extension - Batch Release Date PQ</b>: 2019-09-08</p><p><b>Extension - Batch Retest Date PQ</b>: 2022-09-08</p><p><b>Extension - Actual Yield PQ</b>: 4.8 kg</p><p><b>identifier</b>: SUB1Amgen, SUB1SiteA</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390</td></tr></table></div>
        </text>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
          <extension url="manufacturingDate">
            <valueDateTime value="2019-09-07"/>
          </extension>
          <extension url="batchQuantity">
            <valueQuantity>
              <value value="5.1"/>
              <unit value="kg"/>
            </valueQuantity>
          </extension>
          <extension url="batchUtilization">
            <valueCodeableConcept>
              <coding>
                <system
                        value="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"/>
                <code value="C133991"/>
                <display value="Development"/>
              </coding>
            </valueCodeableConcept>
          </extension>
          <extension url="assignedManufacturer">
            <valueReference>
              <!-- Organization/organization-dxpq-ex1 -->
              <reference
                         value="Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"/>
            </valueReference>
          </extension>
        </extension>
        <!--  local extension  -->
        <extension
                   url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-release-date-pq">
          <valueDateTime value="2019-09-08"/>
        </extension>
        <extension
                   url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-retest-date-pq">
          <valueDateTime value="2022-09-08"/>
        </extension>
        <extension
                   url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-pq">
          <valueQuantity>
            <value value="4.8"/>
            <unit value="kg"/>
          </valueQuantity>
        </extension>
        <identifier>
          <value value="SUB1Amgen"/>
        </identifier>
        <identifier>
          <value value="SUB1SiteA"/>
          <assigner>
            <!-- Organization/organization-dxpq-ex1 -->
            <reference
                       value="Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"/>
          </assigner>
        </identifier>
        <instance value="true"/>
        <code>
          <reference>
            <!-- SubstanceDefinition/substancedefinition-component-substance-dxpq-ex1 -->
            <reference
                       value="SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390"/>
          </reference>
        </code>
      </Substance>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:cb31d747-2338-88d5-342c-8e9c097e4dad"/>
    <resource>
      <Substance>
        <!-- actual-batch-substance-2-unlinked -->
        <id value="cb31d747-2338-88d5-342c-8e9c097e4dad"/>
        <text>
          <status value="extensions"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_cb31d747-2338-88d5-342c-8e9c097e4dad"> </a><p><b>Generated Narrative: Substance</b><a name="cb31d747-2338-88d5-342c-8e9c097e4dad"> </a><a name="hccb31d747-2338-88d5-342c-8e9c097e4dad"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance &quot;cb31d747-2338-88d5-342c-8e9c097e4dad&quot; </p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-07</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 5.2 kg</p><blockquote><p><b>url</b></p><code>batchUtilization</code></blockquote><p><b>value</b>: Development <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.0.0/CodeSystem-v3-nciThesaurus.html">NCI Thesaurus</a>#C133991)</span></p><blockquote><p><b>url</b></p><code>assignedManufacturer</code></blockquote><p><b>value</b>: See on this page: Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c</p></blockquote><p><b>Extension - Batch Release Date PQ</b>: 2019-09-08</p><p><b>Extension - Batch Retest Date PQ</b>: 2022-09-08</p><p><b>Extension - Actual Yield PQ</b>: 4.8 kg</p><p><b>identifier</b>: SUB2Amgen, SUB2SiteA</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390</td></tr></table></div>
        </text>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
          <extension url="manufacturingDate">
            <valueDateTime value="2019-09-07"/>
          </extension>
          <extension url="batchQuantity">
            <valueQuantity>
              <value value="5.2"/>
              <unit value="kg"/>
            </valueQuantity>
          </extension>
          <extension url="batchUtilization">
            <valueCodeableConcept>
              <coding>
                <system
                        value="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"/>
                <code value="C133991"/>
                <display value="Development"/>
              </coding>
            </valueCodeableConcept>
          </extension>
          <extension url="assignedManufacturer">
            <valueReference>
              <!-- Organization/organization-dxpq-ex1 -->
              <reference
                         value="Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"/>
            </valueReference>
          </extension>
        </extension>
        <!--  local extensions  -->
        <extension
                   url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-release-date-pq">
          <valueDateTime value="2019-09-08"/>
        </extension>
        <extension
                   url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-retest-date-pq">
          <valueDateTime value="2022-09-08"/>
        </extension>
        <extension
                   url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-pq">
          <valueQuantity>
            <value value="4.8"/>
            <unit value="kg"/>
          </valueQuantity>
        </extension>
        <identifier>
          <value value="SUB2Amgen"/>
        </identifier>
        <identifier>
          <value value="SUB2SiteA"/>
          <assigner>
            <!-- Organization/organization-dxpq-ex1 -->
            <reference
                       value="Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"/>
          </assigner>
        </identifier>
        <instance value="true"/>
        <code>
          <reference>
            <!-- SubstanceDefinition/substancedefinition-component-substance-dxpq-ex1 -->
            <reference
                       value="SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390"/>
          </reference>
        </code>
      </Substance>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:1551f97b-6f6d-825e-1fb3-44b0b090808c"/>
    <resource>
      <Substance>
        <!-- actual-batch-substance-3-unlinked -->
        <id value="1551f97b-6f6d-825e-1fb3-44b0b090808c"/>
        <text>
          <status value="extensions"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_1551f97b-6f6d-825e-1fb3-44b0b090808c"> </a><p><b>Generated Narrative: Substance</b><a name="1551f97b-6f6d-825e-1fb3-44b0b090808c"> </a><a name="hc1551f97b-6f6d-825e-1fb3-44b0b090808c"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance &quot;1551f97b-6f6d-825e-1fb3-44b0b090808c&quot; </p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-07</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 5.3 kg</p><blockquote><p><b>url</b></p><code>batchUtilization</code></blockquote><p><b>value</b>: Development <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.0.0/CodeSystem-v3-nciThesaurus.html">NCI Thesaurus</a>#C133991)</span></p><blockquote><p><b>url</b></p><code>assignedManufacturer</code></blockquote><p><b>value</b>: See on this page: Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c</p></blockquote><p><b>Extension - Batch Release Date PQ</b>: 2019-09-08</p><p><b>Extension - Batch Retest Date PQ</b>: 2022-09-08</p><p><b>Extension - Actual Yield PQ</b>: 4.8 kg</p><p><b>identifier</b>: SUB3Amgen, SUB3SiteA</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390</td></tr></table></div>
        </text>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
          <extension url="manufacturingDate">
            <valueDateTime value="2019-09-07"/>
          </extension>
          <extension url="batchQuantity">
            <valueQuantity>
              <value value="5.3"/>
              <unit value="kg"/>
            </valueQuantity>
          </extension>
          <extension url="batchUtilization">
            <valueCodeableConcept>
              <coding>
                <system
                        value="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"/>
                <code value="C133991"/>
                <display value="Development"/>
              </coding>
            </valueCodeableConcept>
          </extension>
          <extension url="assignedManufacturer">
            <valueReference>
              <!-- Organization/organization-dxpq-ex1 -->
              <reference
                         value="Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"/>
            </valueReference>
          </extension>
        </extension>
        <!--  local extensions  -->
        <extension
                   url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-release-date-pq">
          <valueDateTime value="2019-09-08"/>
        </extension>
        <extension
                   url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-retest-date-pq">
          <valueDateTime value="2022-09-08"/>
        </extension>
        <extension
                   url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-pq">
          <valueQuantity>
            <value value="4.8"/>
            <unit value="kg"/>
          </valueQuantity>
        </extension>
        <identifier>
          <value value="SUB3Amgen"/>
        </identifier>
        <identifier>
          <value value="SUB3SiteA"/>
          <assigner>
            <!-- Organization/organization-dxpq-ex1 -->
            <reference
                       value="Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"/>
          </assigner>
        </identifier>
        <instance value="true"/>
        <code>
          <reference>
            <!-- SubstanceDefinition/substancedefinition-component-substance-dxpq-ex1 -->
            <reference
                       value="SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390"/>
          </reference>
        </code>
      </Substance>
    </resource>
  </entry>
</Bundle>