Pharmaceutical Quality (Industry)
1.0.0 - STU1
Pharmaceutical Quality (Industry)
1.0.0 - STU1
Pharmaceutical Quality (Industry), published by HL7 International / Biomedical Research and Regulation. This guide is not an authorized publication; it is the continuous build for version 1.0.0 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/uv-dx-pq/ and changes regularly. See the Directory of published versions
{
"resourceType" : "Bundle",
"id" : "bundle-product-impurities-pq-ex2-sub",
"meta" : // Substance Impurities
{
"profile" : [
🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Bundle-product-impurities-pq"
]
},
"type" : "collection",
"entry" : [
{
"fullUrl" : "urn:uuid:03d68d1c-162c-8b6e-70f9-647b0ea97adb",
"resource" : {
"resourceType" : "SubstanceDefinition",
"id" : "substance1",
"text" : {
"status" : "extensions",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"SubstanceDefinition_substance1\"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name=\"substance1\"> </a><a name=\"hcsubstance1\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource SubstanceDefinition "substance1" </p></div><p><b>manufacturer</b>: See on this page: Organization/062bf235-44e2-55c4-9213-bbe5e12d5620</p><h3>Names</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Name</b></td></tr><tr><td style=\"display: none\">*</td><td>Stelbatolol</td></tr></table><blockquote><p><b>relationship</b></p><p><b>Extension - Impurity Origin PQ</b>: Enantiomer of API SM <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-impurity-origin.html\">Impurity Origin Codes</a>#enantiomer "Enantiomer")</span></p><p><b>substanceDefinition</b>: See on this page: SubstanceDefinition/03d68d1c-162c-8b6e-80f9-647b0ea97ad1</p><p><b>type</b>: Impurity Of <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-substance-relationship-type.html\">Substance Relationship Type</a>#Impurity; <a href=\"CodeSystem-impurity-type.html\">Impurity Type Codes</a>#CH-IMP "Chiral Impurity")</span></p><p><b>amount</b>: ND</p></blockquote><blockquote><p><b>relationship</b></p><p><b>Extension - Impurity Origin PQ</b>: Step 1a Process Impurity <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-impurity-origin.html\">Impurity Origin Codes</a>#process "Process Impurity")</span></p><p><b>substanceDefinition</b>: See on this page: SubstanceDefinition/03d68d1c-162c-8b6e-80f9-647b0ea97ad2</p><p><b>type</b>: Impurity Of <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-substance-relationship-type.html\">Substance Relationship Type</a>#Impurity; <a href=\"CodeSystem-impurity-type.html\">Impurity Type Codes</a>#PR-IMP "Process impurity")</span></p><p><b>amount</b>: Range: ND-0.2%</p></blockquote><blockquote><p><b>relationship</b></p><p><b>Extension - Impurity Origin PQ</b>: Step 1a Process Impurity <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-impurity-origin.html\">Impurity Origin Codes</a>#process "Process Impurity")</span></p><p><b>substanceDefinition</b>: See on this page: SubstanceDefinition/03d68d1c-162c-8b6e-80f9-647b0ea97ad9</p><p><b>type</b>: Impurity Of <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-substance-relationship-type.html\">Substance Relationship Type</a>#Impurity; <a href=\"CodeSystem-impurity-type.html\">Impurity Type Codes</a>#PR-IMP "Process impurity")</span></p><p><b>amount</b>: Range: ND–0.3%</p></blockquote><blockquote><p><b>relationship</b></p><p><b>Extension - Impurity Origin PQ</b>: API Starting Material <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-impurity-origin.html\">Impurity Origin Codes</a>#starting-material "Starting Material")</span></p><p><b>substanceDefinition</b>: See on this page: SubstanceDefinition/03d68d1c-162c-8b6e-80f9-647b0ea97ad3</p><p><b>type</b>: Impurity Of <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-substance-relationship-type.html\">Substance Relationship Type</a>#Impurity; <a href=\"CodeSystem-impurity-type.html\">Impurity Type Codes</a>#ST-IMP "Starting material, forced degradation product")</span></p><p><b>amount</b>: Observed only during stress studies</p></blockquote><blockquote><p><b>relationship</b></p><p><b>Extension - Impurity Origin PQ</b>: API Process Intermediate <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-impurity-origin.html\">Impurity Origin Codes</a>#intermediate-material "Intermediate Material")</span></p><p><b>substanceDefinition</b>: See on this page: SubstanceDefinition/03d68d1c-162c-8b6e-80f9-647b0ea97ad4</p><p><b>type</b>: Impurity Of <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-substance-relationship-type.html\">Substance Relationship Type</a>#Impurity; <a href=\"CodeSystem-impurity-type.html\">Impurity Type Codes</a>#INT-IMP "Process intermediate, forced degradation product")</span></p><p><b>amount</b>: Observed only during stress studies</p></blockquote></div>"
},
"manufacturer" : [
{
"reference" : "Organization/062bf235-44e2-55c4-9213-bbe5e12d5620"
}
],
"name" : [
// Organization/substance-manufacturer
{
"name" : "Stelbatolol"
}
],
"relationship" : [
{
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-impurity-origin-pq",
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/impurity-origin",
"code" : "enantiomer",
"display" : "Enantiomer"
}
],
"text" : "Enantiomer of API SM"
}
}
],
"substanceDefinitionReference" : {
"reference" : "SubstanceDefinition/03d68d1c-162c-8b6e-80f9-647b0ea97ad1"
},
"type" : // SubstanceDefinition/impurityEnantiomer
{
"coding" : [
// two codes here, one is more specialised than the other
{
"system" : "http://hl7.org/fhir/substance-relationship-type",
"code" : "Impurity",
"display" : "Impurity Of"
},
{
"system" : "http://terminology.hl7.org/CodeSystem/impurity-type",
"code" : "CH-IMP",
"display" : "Chiral Impurity"
}
]
},
"amountString" : "ND"
},
{
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-impurity-origin-pq",
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/impurity-origin",
"code" : "process",
"display" : "Process Impurity"
}
],
"text" : "Step 1a Process Impurity"
}
}
],
"substanceDefinitionReference" : {
"reference" : "SubstanceDefinition/03d68d1c-162c-8b6e-80f9-647b0ea97ad2"
},
"type" : // SubstanceDefinition/impurity1
{
"coding" : [
{
"system" : "http://hl7.org/fhir/substance-relationship-type",
"code" : "Impurity",
"display" : "Impurity Of"
},
{
"system" : "http://terminology.hl7.org/CodeSystem/impurity-type",
"code" : "PR-IMP",
"display" : "Process impurity"
}
]
},
"amountString" : "Range: ND-0.2%"
},
{
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-impurity-origin-pq",
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/impurity-origin",
"code" : "process",
"display" : "Process Impurity"
}
],
"text" : "Step 1a Process Impurity"
}
}
],
"substanceDefinitionReference" : {
"reference" : "SubstanceDefinition/03d68d1c-162c-8b6e-80f9-647b0ea97ad9"
},
"type" : // SubstanceDefinition/impurity2
{
"coding" : [
{
"system" : "http://hl7.org/fhir/substance-relationship-type",
"code" : "Impurity",
"display" : "Impurity Of"
},
{
"system" : "http://terminology.hl7.org/CodeSystem/impurity-type",
"code" : "PR-IMP",
"display" : "Process impurity"
}
]
},
"amountString" : "Range: ND–0.3%"
},
{
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-impurity-origin-pq",
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/impurity-origin",
"code" : "starting-material",
"display" : "Starting Material"
}
],
"text" : "API Starting Material"
}
}
],
"substanceDefinitionReference" : {
"reference" : "SubstanceDefinition/03d68d1c-162c-8b6e-80f9-647b0ea97ad3"
},
"type" : // SubstanceDefinition/impurityNapthol
{
"coding" : [
{
"system" : "http://hl7.org/fhir/substance-relationship-type",
"code" : "Impurity",
"display" : "Impurity Of"
},
{
"system" : "http://terminology.hl7.org/CodeSystem/impurity-type",
"code" : "ST-IMP",
"display" : "Starting material, forced degradation product"
}
]
},
"amountString" : "Observed only during stress studies"
},
{
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-impurity-origin-pq",
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/impurity-origin",
"code" : "intermediate-material",
"display" : "Intermediate Material"
}
],
"text" : "API Process Intermediate"
}
}
],
"substanceDefinitionReference" : {
"reference" : "SubstanceDefinition/03d68d1c-162c-8b6e-80f9-647b0ea97ad4"
},
"type" : // SubstanceDefinition/impurityPropanol
{
"coding" : [
{
"system" : "http://hl7.org/fhir/substance-relationship-type",
"code" : "Impurity",
"display" : "Impurity Of"
},
{
"system" : "http://terminology.hl7.org/CodeSystem/impurity-type",
"code" : "INT-IMP",
"display" : "Process intermediate, forced degradation product"
}
]
},
"amountString" : "Observed only during stress studies"
}
]
}
},
{
"fullUrl" : "urn:uuid:03d68d1c-162c-8b6e-80f9-647b0ea97ad1",
"resource" : {
"resourceType" : "SubstanceDefinition",
"id" : "03d68d1c-162c-8b6e-80f9-647b0ea97ad1",
"text" : // impurityEnantiomer
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"SubstanceDefinition_03d68d1c-162c-8b6e-80f9-647b0ea97ad1\"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name=\"03d68d1c-162c-8b6e-80f9-647b0ea97ad1\"> </a><a name=\"hc03d68d1c-162c-8b6e-80f9-647b0ea97ad1\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource SubstanceDefinition "03d68d1c-162c-8b6e-80f9-647b0ea97ad1" </p></div><blockquote><p><b>characterization</b></p><p><b>technique</b>: Enantiomeric purity by LC <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>characterization</b></p><p><b>technique</b>: Mass spectrometry <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: Rule-based (Q)Sar <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#1233444)</span></p><p><b>value</b>: Negative <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-value-pq-example.html\">Substance Property Value - example</a>#negative)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: Statistical (Q)Sar <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#123555)</span></p><p><b>value</b>: Negative <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-value-pq-example.html\">Substance Property Value - example</a>#negative)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: ICH M7 Classification <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#123556)</span></p><p><b>value</b>: Class 5 <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-value-pq-example.html\">Substance Property Value - example</a>#class-5)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: Mutagenicity Comment <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#123557)</span></p><p><b>value</b>: Treated as non-mutagenic due to lack of alerting structure <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><h3>MolecularWeights</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Amount</b></td></tr><tr><td style=\"display: none\">*</td><td>295.80 g/mole<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM code g/mol = 'g/mol')</span></td></tr></table><blockquote><p><b>structure</b></p><h3>Representations</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Document</b></td></tr><tr><td style=\"display: none\">*</td><td>See on this page: DocumentReference/13d68d1c-162c-8b6e-80f9-647b0ea97ad1</td></tr></table></blockquote><h3>Names</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Name</b></td></tr><tr><td style=\"display: none\">*</td><td>R-enantiomer of stelbatalol</td></tr></table></div>"
},
"characterization" : [
{
"technique" : {
"text" : "Enantiomeric purity by LC"
}
},
{
"technique" : {
"text" : "Mass spectrometry"
}
}
],
"property" : [
{
"type" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example",
"code" : "1233444",
"display" : "Rule-based (Q)Sar"
}
]
},
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example",
"code" : "negative",
"display" : "Negative"
}
]
}
},
{
"type" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example",
"code" : "123555",
"display" : "Statistical (Q)Sar"
}
]
},
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example",
"code" : "negative",
"display" : "Negative"
}
]
}
},
{
"type" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example",
"code" : "123556",
"display" : "ICH M7 Classification"
}
]
},
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example",
"code" : "class-5",
"display" : "Class 5"
}
]
}
},
{
"type" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example",
"code" : "123557",
"display" : "Mutagenicity Comment"
}
]
},
"valueCodeableConcept" : {
"text" : "Treated as non-mutagenic due to lack of alerting structure"
}
}
],
"molecularWeight" : [
{
"amount" : {
"value" : 295.80,
"unit" : "g/mole",
"system" : "http://unitsofmeasure.org",
"code" : "g/mol"
}
}
],
"structure" : {
"representation" : [
{
"document" : {
"reference" : "DocumentReference/13d68d1c-162c-8b6e-80f9-647b0ea97ad1"
}
}
]
},
"name" : [
// DocumentReference/impurityEnantiomerdoc
{
"name" : "R-enantiomer of stelbatalol"
}
]
}
},
{
"fullUrl" : "urn:uuid:13d68d1c-162c-8b6e-80f9-647b0ea97ad1",
"resource" : {
"resourceType" : "DocumentReference",
"id" : "13d68d1c-162c-8b6e-80f9-647b0ea97ad1",
"text" : // impurityEnantiomerdoc
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"DocumentReference_13d68d1c-162c-8b6e-80f9-647b0ea97ad1\"> </a><p><b>Generated Narrative: DocumentReference</b><a name=\"13d68d1c-162c-8b6e-80f9-647b0ea97ad1\"> </a><a name=\"hc13d68d1c-162c-8b6e-80f9-647b0ea97ad1\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource DocumentReference "13d68d1c-162c-8b6e-80f9-647b0ea97ad1" </p></div><p><b>status</b>: current</p><blockquote><p><b>content</b></p><h3>Attachments</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>ContentType</b></td><td><b>Data</b></td></tr><tr><td style=\"display: none\">*</td><td>image/x-png</td><td>(base64 data - 4429 bytes)</td></tr></table></blockquote></div>"
},
"status" : "current",
"content" : [
{
"attachment" : {
"contentType" : "image/x-png",
"data" : 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"
}
}
]
}
},
{
"fullUrl" : "urn:uuid:03d68d1c-162c-8b6e-80f9-647b0ea97ad2",
"resource" : {
"resourceType" : "SubstanceDefinition",
"id" : "03d68d1c-162c-8b6e-80f9-647b0ea97ad2",
"text" : // impurity1
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"SubstanceDefinition_03d68d1c-162c-8b6e-80f9-647b0ea97ad2\"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name=\"03d68d1c-162c-8b6e-80f9-647b0ea97ad2\"> </a><a name=\"hc03d68d1c-162c-8b6e-80f9-647b0ea97ad2\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource SubstanceDefinition "03d68d1c-162c-8b6e-80f9-647b0ea97ad2" </p></div><h3>Characterizations</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Technique</b></td></tr><tr><td style=\"display: none\">*</td><td>Organic impurities by HPLC <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table><blockquote><p><b>property</b></p><p><b>type</b>: Rule-based (Q)Sar <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#1233444)</span></p><p><b>value</b>: Negative <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-value-pq-example.html\">Substance Property Value - example</a>#negative)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: Statistical (Q)Sar <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#123555)</span></p><p><b>value</b>: Negative <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-value-pq-example.html\">Substance Property Value - example</a>#negative)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: ICH M7 Classification <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#123556)</span></p><p><b>value</b>: Class 5 <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-value-pq-example.html\">Substance Property Value - example</a>#class-5)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: Mutagenicity Comment <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#123557)</span></p><p><b>value</b>: Treated as non-mutagenic due to lack of alerting structure <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><h3>MolecularWeights</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Amount</b></td></tr><tr><td style=\"display: none\">*</td><td>344.4 g/mole<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM code g/mol = 'g/mol')</span></td></tr></table><blockquote><p><b>structure</b></p><h3>Representations</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Document</b></td></tr><tr><td style=\"display: none\">*</td><td>See on this page: DocumentReference/13d68d1c-162c-8b6e-80f9-647b0ea97ad2</td></tr></table></blockquote><h3>Names</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Name</b></td></tr><tr><td style=\"display: none\">*</td><td>Impurity 1</td></tr></table></div>"
},
"characterization" : [
{
"technique" : {
"text" : "Organic impurities by HPLC"
}
}
],
"property" : [
{
"type" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example",
"code" : "1233444",
"display" : "Rule-based (Q)Sar"
}
]
},
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example",
"code" : "negative",
"display" : "Negative"
}
]
}
},
{
"type" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example",
"code" : "123555",
"display" : "Statistical (Q)Sar"
}
]
},
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example",
"code" : "negative",
"display" : "Negative"
}
]
}
},
{
"type" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example",
"code" : "123556",
"display" : "ICH M7 Classification"
}
]
},
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example",
"code" : "class-5",
"display" : "Class 5"
}
]
}
},
{
"type" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example",
"code" : "123557",
"display" : "Mutagenicity Comment"
}
]
},
"valueCodeableConcept" : {
"text" : "Treated as non-mutagenic due to lack of alerting structure"
}
}
],
"molecularWeight" : [
{
"amount" : {
"value" : 344.4,
"unit" : "g/mole",
"system" : "http://unitsofmeasure.org",
"code" : "g/mol"
}
}
],
"structure" : {
"representation" : [
{
"document" : {
"reference" : "DocumentReference/13d68d1c-162c-8b6e-80f9-647b0ea97ad2"
}
}
]
},
"name" : [
// DocumentReference/impurity1doc
{
"name" : "Impurity 1"
}
]
}
},
{
"fullUrl" : "urn:uuid:13d68d1c-162c-8b6e-80f9-647b0ea97ad2",
"resource" : {
"resourceType" : "DocumentReference",
"id" : "13d68d1c-162c-8b6e-80f9-647b0ea97ad2",
"text" : // impurity1doc
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"DocumentReference_13d68d1c-162c-8b6e-80f9-647b0ea97ad2\"> </a><p><b>Generated Narrative: DocumentReference</b><a name=\"13d68d1c-162c-8b6e-80f9-647b0ea97ad2\"> </a><a name=\"hc13d68d1c-162c-8b6e-80f9-647b0ea97ad2\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource DocumentReference "13d68d1c-162c-8b6e-80f9-647b0ea97ad2" </p></div><p><b>status</b>: current</p><blockquote><p><b>content</b></p><h3>Attachments</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>ContentType</b></td><td><b>Data</b></td></tr><tr><td style=\"display: none\">*</td><td>image/x-png</td><td>(base64 data - 7004 bytes)</td></tr></table></blockquote></div>"
},
"status" : "current",
"content" : [
{
"attachment" : {
"contentType" : "image/x-png",
"data" : 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}
}
]
}
},
{
"fullUrl" : "urn:uuid:03d68d1c-162c-8b6e-80f9-647b0ea97ad9",
"resource" : {
"resourceType" : "SubstanceDefinition",
"id" : "03d68d1c-162c-8b6e-80f9-647b0ea97ad9",
"text" : // impurity2
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"SubstanceDefinition_03d68d1c-162c-8b6e-80f9-647b0ea97ad9\"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name=\"03d68d1c-162c-8b6e-80f9-647b0ea97ad9\"> </a><a name=\"hc03d68d1c-162c-8b6e-80f9-647b0ea97ad9\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource SubstanceDefinition "03d68d1c-162c-8b6e-80f9-647b0ea97ad9" </p></div><h3>Characterizations</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Technique</b></td></tr><tr><td style=\"display: none\">*</td><td>Organic impurities by LC <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table><blockquote><p><b>property</b></p><p><b>type</b>: Rule-based (Q)Sar <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#1233444)</span></p><p><b>value</b>: Negative <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-value-pq-example.html\">Substance Property Value - example</a>#negative)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: Statistical (Q)Sar <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#123555)</span></p><p><b>value</b>: Negative <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-value-pq-example.html\">Substance Property Value - example</a>#negative)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: ICH M7 Classification <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#123556)</span></p><p><b>value</b>: Class 5 <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-value-pq-example.html\">Substance Property Value - example</a>#class-5)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: Mutagenicity Comment <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#123557)</span></p><p><b>value</b>: Treated as non-mutagenic due to lack of alerting structure <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><h3>MolecularWeights</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Amount</b></td></tr><tr><td style=\"display: none\">*</td><td>459.58 g/mole<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM code g/mol = 'g/mol')</span></td></tr></table><blockquote><p><b>structure</b></p><h3>Representations</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Document</b></td></tr><tr><td style=\"display: none\">*</td><td>See on this page: DocumentReference/13d68d1c-162c-8b6e-80f9-647b0ea97ad9</td></tr></table></blockquote><h3>Names</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Name</b></td></tr><tr><td style=\"display: none\">*</td><td>Impurity 2</td></tr></table></div>"
},
"characterization" : [
{
"technique" : {
"text" : "Organic impurities by LC"
}
}
],
"property" : [
{
"type" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example",
"code" : "1233444",
"display" : "Rule-based (Q)Sar"
}
]
},
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example",
"code" : "negative",
"display" : "Negative"
}
]
}
},
{
"type" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example",
"code" : "123555",
"display" : "Statistical (Q)Sar"
}
]
},
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example",
"code" : "negative",
"display" : "Negative"
}
]
}
},
{
"type" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example",
"code" : "123556",
"display" : "ICH M7 Classification"
}
]
},
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example",
"code" : "class-5",
"display" : "Class 5"
}
]
}
},
{
"type" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example",
"code" : "123557",
"display" : "Mutagenicity Comment"
}
]
},
"valueCodeableConcept" : {
"text" : "Treated as non-mutagenic due to lack of alerting structure"
}
}
],
"molecularWeight" : [
{
"amount" : {
"value" : 459.58,
"unit" : "g/mole",
"system" : "http://unitsofmeasure.org",
"code" : "g/mol"
}
}
],
"structure" : {
"representation" : [
{
"document" : {
"reference" : "DocumentReference/13d68d1c-162c-8b6e-80f9-647b0ea97ad9"
}
}
]
},
"name" : [
// DocumentReference/impurity2doc
{
"name" : "Impurity 2"
}
]
}
},
{
"fullUrl" : "urn:uuid:13d68d1c-162c-8b6e-80f9-647b0ea97ad9",
"resource" : {
"resourceType" : "DocumentReference",
"id" : "13d68d1c-162c-8b6e-80f9-647b0ea97ad9",
"text" : // impurity2doc
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"DocumentReference_13d68d1c-162c-8b6e-80f9-647b0ea97ad9\"> </a><p><b>Generated Narrative: DocumentReference</b><a name=\"13d68d1c-162c-8b6e-80f9-647b0ea97ad9\"> </a><a name=\"hc13d68d1c-162c-8b6e-80f9-647b0ea97ad9\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource DocumentReference "13d68d1c-162c-8b6e-80f9-647b0ea97ad9" </p></div><p><b>status</b>: current</p><blockquote><p><b>content</b></p><h3>Attachments</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>ContentType</b></td><td><b>Data</b></td></tr><tr><td style=\"display: none\">*</td><td>image/x-png</td><td>(base64 data - 7149 bytes)</td></tr></table></blockquote></div>"
},
"status" : "current",
"content" : [
{
"attachment" : {
"contentType" : "image/x-png",
"data" : 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"
}
}
]
}
},
{
"fullUrl" : "urn:uuid:03d68d1c-162c-8b6e-80f9-647b0ea97ad3",
"resource" : {
"resourceType" : "SubstanceDefinition",
"id" : "03d68d1c-162c-8b6e-80f9-647b0ea97ad3",
"text" : // impurityNapthol
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"SubstanceDefinition_03d68d1c-162c-8b6e-80f9-647b0ea97ad3\"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name=\"03d68d1c-162c-8b6e-80f9-647b0ea97ad3\"> </a><a name=\"hc03d68d1c-162c-8b6e-80f9-647b0ea97ad3\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource SubstanceDefinition "03d68d1c-162c-8b6e-80f9-647b0ea97ad3" </p></div><blockquote><p><b>characterization</b></p><p><b>technique</b>: Organic impurities by HPLC <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>characterization</b></p><p><b>technique</b>: Chromatographic retention <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: Rule-based (Q)Sar <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#1233444)</span></p><p><b>value</b>: Negative <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-value-pq-example.html\">Substance Property Value - example</a>#negative)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: Statistical (Q)Sar <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#123555)</span></p><p><b>value</b>: Negative <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-value-pq-example.html\">Substance Property Value - example</a>#negative)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: ICH M7 Classification <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#123556)</span></p><p><b>value</b>: Class 5 <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-value-pq-example.html\">Substance Property Value - example</a>#class-5)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: Mutagenicity Comment <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#123557)</span></p><p><b>value</b>: Treated as non-mutagenic due to lack of alerting structure <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><h3>MolecularWeights</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Amount</b></td></tr><tr><td style=\"display: none\">*</td><td>144.173 g/mole<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM code g/mol = 'g/mol')</span></td></tr></table><blockquote><p><b>structure</b></p><blockquote><p><b>representation</b></p><p><b>document</b>: See on this page: DocumentReference/13d68d1c-162c-8b6e-80f9-647b0ea97ad3</p></blockquote><blockquote><p><b>representation</b></p><p><b>type</b>: SMILES <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-substance-representation-format.html\">Substance Representation Format</a>#SMILES)</span></p><p><b>representation</b>: OC1=CC2=C(C=C1)C=CC=C2</p></blockquote><blockquote><p><b>representation</b></p><p><b>type</b>: InChI <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-substance-representation-format.html\">Substance Representation Format</a>#InChI)</span></p><p><b>representation</b>: 1S/C10H8O/c11-10-6-5-8-3-1-2-4-9(8)7-10/h1-7,11H</p></blockquote></blockquote><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td></tr><tr><td style=\"display: none\">*</td><td>2-Naphthol <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.0.0/CodeSystem-CAS.html\">Chemical abstract codes</a>#135-19-3)</span></td></tr></table><h3>Names</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Name</b></td></tr><tr><td style=\"display: none\">*</td><td>β-naphthol</td></tr></table></div>"
},
"characterization" : [
{
"technique" : {
"text" : "Organic impurities by HPLC"
}
},
{
"technique" : {
"text" : "Chromatographic retention"
}
}
],
"property" : [
{
"type" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example",
"code" : "1233444",
"display" : "Rule-based (Q)Sar"
}
]
},
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example",
"code" : "negative",
"display" : "Negative"
}
]
}
},
{
"type" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example",
"code" : "123555",
"display" : "Statistical (Q)Sar"
}
]
},
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example",
"code" : "negative",
"display" : "Negative"
}
]
}
},
{
"type" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example",
"code" : "123556",
"display" : "ICH M7 Classification"
}
]
},
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example",
"code" : "class-5",
"display" : "Class 5"
}
]
}
},
{
"type" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example",
"code" : "123557",
"display" : "Mutagenicity Comment"
}
]
},
"valueCodeableConcept" : {
"text" : "Treated as non-mutagenic due to lack of alerting structure"
}
}
],
"molecularWeight" : [
{
"amount" : {
"value" : 144.173,
"unit" : "g/mole",
"system" : "http://unitsofmeasure.org",
"code" : "g/mol"
}
}
],
"structure" : {
"representation" : [
{
"document" : {
"reference" : "DocumentReference/13d68d1c-162c-8b6e-80f9-647b0ea97ad3"
}
},
// DocumentReference/impurityNaptholDoc
{
"type" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/substance-representation-format",
"code" : "SMILES",
"display" : "SMILES"
}
]
},
"representation" : "OC1=CC2=C(C=C1)C=CC=C2"
},
{
"type" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/substance-representation-format",
"code" : "InChI",
"display" : "InChI"
}
]
},
"representation" : "1S/C10H8O/c11-10-6-5-8-3-1-2-4-9(8)7-10/h1-7,11H"
}
]
},
"code" : [
{
"code" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/CAS",
"code" : "135-19-3",
"display" : "2-Naphthol"
}
]
}
}
],
"name" : [
{
"name" : "β-naphthol"
}
]
}
},
{
"fullUrl" : "urn:uuid:13d68d1c-162c-8b6e-80f9-647b0ea97ad3",
"resource" : {
"resourceType" : "DocumentReference",
"id" : "13d68d1c-162c-8b6e-80f9-647b0ea97ad3",
"text" : // impurityNaptholDoc
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"DocumentReference_13d68d1c-162c-8b6e-80f9-647b0ea97ad3\"> </a><p><b>Generated Narrative: DocumentReference</b><a name=\"13d68d1c-162c-8b6e-80f9-647b0ea97ad3\"> </a><a name=\"hc13d68d1c-162c-8b6e-80f9-647b0ea97ad3\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource DocumentReference "13d68d1c-162c-8b6e-80f9-647b0ea97ad3" </p></div><p><b>status</b>: current</p><blockquote><p><b>content</b></p><h3>Attachments</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>ContentType</b></td><td><b>Data</b></td></tr><tr><td style=\"display: none\">*</td><td>image/x-png</td><td>(base64 data - 4093 bytes)</td></tr></table></blockquote></div>"
},
"status" : "current",
"content" : [
{
"attachment" : {
"contentType" : "image/x-png",
"data" : 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7OZmimRQtXm6kqp6dAno+SnNRMVp/1RUcQDdGMdKzZ0/cRTdl6gh73usGj+HOLBuSUb1gQoA6kLIedoInddrwLCDe+BcaGkqahNAs32kEDTAgzIRVq1bpd0tFb9j5/nJS9KZNm2iAKN5mzpwpGe/kyZMTJkyAW2JjY+WLGOx4XYItAsgygYJTvASHXoJJRQPET0KH8gfW5ayu7uICOPSeeQqnlJQUMhb8Rue7fPnyBg0aRERErF69WtZjOm05tmyuST/U2VgrPj4+IyMjISGBz3369HHKW9zcDif8PwCob+jQoX5+fpTFxJbyrpLUo9NvjmneBKHJS0tLo9OqVKlS8+bNSZCqtu/+hfkV2g5CvMqgfPnyYn+8gLgyp7y9vZ3+fKBSbNVXElTb2dnZQUFBZFBdv2pwJZxjJw/0hucx2PsDfwPULn7gJ1Dc7AAAAABJRU5ErkJggg=="
}
}
]
}
},
{
"fullUrl" : "urn:uuid:03d68d1c-162c-8b6e-80f9-647b0ea97ad4",
"resource" : {
"resourceType" : "SubstanceDefinition",
"id" : "03d68d1c-162c-8b6e-80f9-647b0ea97ad4",
"text" : // impurityPropanol
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"SubstanceDefinition_03d68d1c-162c-8b6e-80f9-647b0ea97ad4\"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name=\"03d68d1c-162c-8b6e-80f9-647b0ea97ad4\"> </a><a name=\"hc03d68d1c-162c-8b6e-80f9-647b0ea97ad4\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource SubstanceDefinition "03d68d1c-162c-8b6e-80f9-647b0ea97ad4" </p></div><blockquote><p><b>characterization</b></p><p><b>technique</b>: Impurity content by LC-MS <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>characterization</b></p><p><b>technique</b>: UV spectroscopy <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>characterization</b></p><p><b>technique</b>: NMR spectroscopy <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: Rule-based (Q)Sar <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#1233444)</span></p><p><b>value</b>: Positive <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-value-pq-example.html\">Substance Property Value - example</a>#positive)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: Statistical (Q)Sar <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#123555)</span></p><p><b>value</b>: Positive <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-value-pq-example.html\">Substance Property Value - example</a>#positive)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: ICH M7 Classification <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#123556)</span></p><p><b>value</b>: Class 2 <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-value-pq-example.html\">Substance Property Value - example</a>#class-2)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: Mutagenicity Comment <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#123557)</span></p><p><b>value</b>: Control at or below qualification threshold <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><h3>MolecularWeights</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Amount</b></td></tr><tr><td style=\"display: none\">*</td><td>245.32 g/mole<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM code g/mol = 'g/mol')</span></td></tr></table><blockquote><p><b>structure</b></p><h3>Representations</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Document</b></td></tr><tr><td style=\"display: none\">*</td><td>See on this page: DocumentReference/13d68d1c-162c-8b6e-80f9-647b0ea97ad4</td></tr></table></blockquote><h3>Names</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Name</b></td></tr><tr><td style=\"display: none\">*</td><td>1-(Ethylamino)-3-(2-naphthyloxy)-2-propanol</td></tr></table></div>"
},
"characterization" : [
{
"technique" : {
"text" : "Impurity content by LC-MS"
}
},
{
"technique" : {
"text" : "UV spectroscopy"
}
},
{
"technique" : {
"text" : "NMR spectroscopy"
}
}
],
"property" : [
{
"type" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example",
"code" : "1233444",
"display" : "Rule-based (Q)Sar"
}
]
},
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example",
"code" : "positive",
"display" : "Positive"
}
]
}
},
{
"type" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example",
"code" : "123555",
"display" : "Statistical (Q)Sar"
}
]
},
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example",
"code" : "positive",
"display" : "Positive"
}
]
}
},
{
"type" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example",
"code" : "123556",
"display" : "ICH M7 Classification"
}
]
},
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example",
"code" : "class-2",
"display" : "Class 2"
}
]
}
},
{
"type" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example",
"code" : "123557",
"display" : "Mutagenicity Comment"
}
]
},
"valueCodeableConcept" : {
"text" : "Control at or below qualification threshold"
}
}
],
"molecularWeight" : [
{
"amount" : {
"value" : 245.32,
"unit" : "g/mole",
"system" : "http://unitsofmeasure.org",
"code" : "g/mol"
}
}
],
"structure" : {
"representation" : [
{
"document" : {
"reference" : "DocumentReference/13d68d1c-162c-8b6e-80f9-647b0ea97ad4"
}
}
]
},
"name" : [
// DocumentReference/impurityPropanolDoc
// not in CAS
{
"name" : "1-(Ethylamino)-3-(2-naphthyloxy)-2-propanol"
}
]
}
},
{
"fullUrl" : "urn:uuid:13d68d1c-162c-8b6e-80f9-647b0ea97ad4",
"resource" : {
"resourceType" : "DocumentReference",
"id" : "13d68d1c-162c-8b6e-80f9-647b0ea97ad4",
"text" : // impurityPropanolDoc
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"DocumentReference_13d68d1c-162c-8b6e-80f9-647b0ea97ad4\"> </a><p><b>Generated Narrative: DocumentReference</b><a name=\"13d68d1c-162c-8b6e-80f9-647b0ea97ad4\"> </a><a name=\"hc13d68d1c-162c-8b6e-80f9-647b0ea97ad4\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource DocumentReference "13d68d1c-162c-8b6e-80f9-647b0ea97ad4" </p></div><p><b>status</b>: current</p><blockquote><p><b>content</b></p><h3>Attachments</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>ContentType</b></td><td><b>Data</b></td></tr><tr><td style=\"display: none\">*</td><td>image/x-png</td><td>(base64 data - 5119 bytes)</td></tr></table></blockquote></div>"
},
"status" : "current",
"content" : [
{
"attachment" : {
"contentType" : "image/x-png",
"data" : "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"
}
}
]
}
},
{
"fullUrl" : "urn:uuid:062bf235-44e2-55c4-9213-bbe5e12d5620",
"resource" : {
"resourceType" : "Organization",
"id" : "062bf235-44e2-55c4-9213-bbe5e12d5620",
"text" : // substance-manufacturer
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Organization_062bf235-44e2-55c4-9213-bbe5e12d5620\"> </a><p><b>Generated Narrative: Organization</b><a name=\"062bf235-44e2-55c4-9213-bbe5e12d5620\"> </a><a name=\"hc062bf235-44e2-55c4-9213-bbe5e12d5620\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Organization "062bf235-44e2-55c4-9213-bbe5e12d5620" </p></div><p><b>identifier</b>: <code>urn:oid:2.16.840.1.113883.4.82</code>/3003040516</p><p><b>active</b>: true</p><p><b>type</b>: Drug Substance Manufacture <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-pharmaceutical-organization-type.html\">Pharmaceutical Organization Type Codes</a>#drug-substance-manufacture)</span></p><p><b>name</b>: AAA Molybdenum Products, Inc.</p><h3>Contacts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Address</b></td></tr><tr><td style=\"display: none\">*</td><td>7233 W 116th Pl Ste C Broomfield Colorado 80020 USA </td></tr></table></div>"
},
"identifier" : [
{
"system" : "urn:oid:2.16.840.1.113883.4.82",
"value" : "3003040516"
}
],
"active" : true,
"type" : [
// FDA establishment identifier
{
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/pharmaceutical-organization-type",
"code" : "drug-substance-manufacture",
"display" : "Drug Substance Manufacture"
}
]
}
],
"name" : "AAA Molybdenum Products, Inc.",
"contact" : [
{
"address" : {
"line" : [
"7233 W 116th Pl",
"Ste C"
],
"city" : "Broomfield",
"state" : "Colorado",
"postalCode" : "80020",
"country" : "USA"
}
}
]
}
}
]
}
IG © HL7 International / Biomedical Research and Regulation. Package hl7.fhir.uv.pharm-quality#1.0.0 based on FHIR 5.0.0. Generated 2024-05-08
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