Genomics Reporting Implementation Guide
4.0.0-cibuild - CI Build
Genomics Reporting Implementation Guide
4.0.0-cibuild - CI Build
Genomics Reporting Implementation Guide, published by HL7 International / Clinical Genomics. This guide is not an authorized publication; it is the continuous build for version 4.0.0-cibuild built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/genomics-reporting/ and changes regularly. See the Directory of published versions
@prefix fhir: <http://hl7.org/fhir/> . @prefix loinc: <http://loinc.org/rdf#> . @prefix owl: <http://www.w3.org/2002/07/owl#> . @prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> . @prefix xsd: <http://www.w3.org/2001/XMLSchema#> . # - resource ------------------------------------------------------------------- <http://hl7.org/fhir/Bundle/bundle-oncologyexamples-r4-withGrouping> a fhir:Bundle ; fhir:nodeRole fhir:treeRoot ; fhir:Resource.id [ fhir:value "bundle-oncologyexamples-r4-withGrouping"] ; fhir:Bundle.type [ fhir:value "transaction"] ; fhir:Bundle.entry [ fhir:index 0 ; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d" ] ; fhir:Bundle.entry.resource <urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d> ; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ] ; fhir:Bundle.entry.request.url [ fhir:value "Patient" ] ] ], [ fhir:index 1 ; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef" ] ; fhir:Bundle.entry.resource <urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef> ; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ] ; fhir:Bundle.entry.request.url [ fhir:value "Practitioner" ] ] ], [ fhir:index 2 ; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:a5d6a6a9-4859-480e-85b2-56974fef3b9d" ] ; fhir:Bundle.entry.resource <urn:uuid:a5d6a6a9-4859-480e-85b2-56974fef3b9d> ; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ] ; fhir:Bundle.entry.request.url [ fhir:value "Specimen" ] ] ], [ fhir:index 3 ; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:40e85eda-4d31-4bd2-a5a0-c39d63f9824f" ] ; fhir:Bundle.entry.resource <urn:uuid:40e85eda-4d31-4bd2-a5a0-c39d63f9824f> ; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ] ; fhir:Bundle.entry.request.url [ fhir:value "Observation" ] ] ], [ fhir:index 4 ; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:64b91716-6431-41bd-8fd4-7ac99bebdee9" ] ; fhir:Bundle.entry.resource <urn:uuid:64b91716-6431-41bd-8fd4-7ac99bebdee9> ; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ] ; fhir:Bundle.entry.request.url [ fhir:value "Observation" ] ] ], [ fhir:index 5 ; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12d" ] ; fhir:Bundle.entry.resource <urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12d> ; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ] ; fhir:Bundle.entry.request.url [ fhir:value "Observation" ] ] ], [ fhir:index 6 ; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:772de7d7-e1bd-4183-bdb5-cea8eda317cd" ] ; fhir:Bundle.entry.resource <urn:uuid:772de7d7-e1bd-4183-bdb5-cea8eda317cd> ; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ] ; fhir:Bundle.entry.request.url [ fhir:value "Observation" ] ] ], [ fhir:index 7 ; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:b33eb7ec-d83e-49d2-b0f3-729d024ebe01" ] ; fhir:Bundle.entry.resource <urn:uuid:b33eb7ec-d83e-49d2-b0f3-729d024ebe01> ; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ] ; fhir:Bundle.entry.request.url [ fhir:value "Observation" ] ] ], [ fhir:index 8 ; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:1bf9642d-fd1c-4819-8c5d-44fae4bad524" ] ; fhir:Bundle.entry.resource <urn:uuid:1bf9642d-fd1c-4819-8c5d-44fae4bad524> ; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ] ; fhir:Bundle.entry.request.url [ fhir:value "Observation" ] ] ], [ fhir:index 9 ; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:1301943b-55db-4adf-8355-3635f7268a1b" ] ; fhir:Bundle.entry.resource <urn:uuid:1301943b-55db-4adf-8355-3635f7268a1b> ; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ] ; fhir:Bundle.entry.request.url [ fhir:value "Observation" ] ] ], [ fhir:index 10 ; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:05713d1c-0df5-46d5-a5a9-2085eef56c20" ] ; fhir:Bundle.entry.resource <urn:uuid:05713d1c-0df5-46d5-a5a9-2085eef56c20> ; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ] ; fhir:Bundle.entry.request.url [ fhir:value "Observation" ] ] ], [ fhir:index 11 ; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:294f1401-e2eb-4df1-b6d2-09e1b7a6eca4" ] ; fhir:Bundle.entry.resource <urn:uuid:294f1401-e2eb-4df1-b6d2-09e1b7a6eca4> ; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ] ; fhir:Bundle.entry.request.url [ fhir:value "Observation" ] ] ], [ fhir:index 12 ; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12f" ] ; fhir:Bundle.entry.resource <urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12f> ; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ] ; fhir:Bundle.entry.request.url [ fhir:value "Observation" ] ] ], [ fhir:index 13 ; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12e" ] ; fhir:Bundle.entry.resource <urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12e> ; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ] ; fhir:Bundle.entry.request.url [ fhir:value "Observation" ] ] ], [ fhir:index 14 ; fhir:Bundle.entry.fullUrl [ fhir:value "urn:uuid:ad7a499b-a43b-4cc8-bf46-cac62d9ecae5" ] ; fhir:Bundle.entry.resource <urn:uuid:ad7a499b-a43b-4cc8-bf46-cac62d9ecae5> ; fhir:Bundle.entry.request [ fhir:Bundle.entry.request.method [ fhir:value "POST" ] ; fhir:Bundle.entry.request.url [ fhir:value "DiagnosticReport" ] ] ] . <urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d> a fhir:Patient ; fhir:Resource.id [ fhir:value "Inline-Instance-for-oncologyexamples-r4-withGrouping-1"] ; fhir:DomainResource.text [ fhir:Narrative.status [ fhir:value "generated" ] ; fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Patient_Inline-Instance-for-oncologyexamples-r4-withGrouping-1\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Patient Inline-Instance-for-oncologyexamples-r4-withGrouping-1</b></p><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-1\"> </a><a name=\"hcInline-Instance-for-oncologyexamples-r4-withGrouping-1\"> </a><p style=\"border: 1px #661aff solid; background-color: #e6e6ff; padding: 10px;\">Carrot John Mr Male, DoB: 1962-12-31 ( 1007)</p><hr/><table class=\"grid\"><tr><td style=\"background-color: #f3f5da\" title=\"Patient Links\">Links:</td><td colspan=\"3\"><ul><li>General Practitioner: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Practitioner Akerman Philip Prof </a></li></ul></td></tr></table></div>" ] ; fhir:Patient.identifier [ fhir:index 0 ; fhir:Identifier.value [ fhir:value "1007" ] ] ; fhir:Patient.name [ fhir:index 0 ; fhir:HumanName.given [ fhir:value "Carrot" ; fhir:index 0 ], [ fhir:value "John" ; fhir:index 1 ], [ fhir:value "Mr" ; fhir:index 2 ] ] ; fhir:Patient.gender [ fhir:value "male"] ; fhir:Patient.birthDate [ fhir:value "1962-12-31"^^xsd:date] ; fhir:Patient.generalPractitioner [ fhir:index 0 ; fhir:Reference.reference [ fhir:value "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef" ] ] . <urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef> a fhir:Practitioner ; fhir:Resource.id [ fhir:value "Inline-Instance-for-oncologyexamples-r4-withGrouping-2"] ; fhir:DomainResource.text [ fhir:Narrative.status [ fhir:value "generated" ] ; fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Practitioner_Inline-Instance-for-oncologyexamples-r4-withGrouping-2\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Practitioner Inline-Instance-for-oncologyexamples-r4-withGrouping-2</b></p><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-2\"> </a><a name=\"hcInline-Instance-for-oncologyexamples-r4-withGrouping-2\"> </a><p><b>identifier</b>: 4654765876</p><p><b>name</b>: Akerman Philip Prof </p><p><b>address</b>: Castro Valley CA </p></div>" ] ; fhir:Practitioner.identifier [ fhir:index 0 ; fhir:Identifier.value [ fhir:value "4654765876" ] ] ; fhir:Practitioner.name [ fhir:index 0 ; fhir:HumanName.given [ fhir:value "Akerman" ; fhir:index 0 ], [ fhir:value "Philip" ; fhir:index 1 ], [ fhir:value "Prof" ; fhir:index 2 ] ] ; fhir:Practitioner.address [ fhir:index 0 ; fhir:Address.city [ fhir:value "Castro Valley" ] ; fhir:Address.state [ fhir:value "CA" ] ] . <urn:uuid:a5d6a6a9-4859-480e-85b2-56974fef3b9d> a fhir:Specimen ; fhir:Resource.id [ fhir:value "Inline-Instance-for-oncologyexamples-r4-withGrouping-3"] ; fhir:DomainResource.text [ fhir:Narrative.status [ fhir:value "generated" ] ; fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Specimen_Inline-Instance-for-oncologyexamples-r4-withGrouping-3\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Specimen Inline-Instance-for-oncologyexamples-r4-withGrouping-3</b></p><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-3\"> </a><a name=\"hcInline-Instance-for-oncologyexamples-r4-withGrouping-3\"> </a><p><b>identifier</b>: 076e1948-2217-11e9-94d8-12e241dc1f66</p><p><b>status</b>: Available</p><p><b>subject</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-d0b4affa-91d6-46d1-af01-b30d9f16ef6d\">Carrot John Mr Male, DoB: 1962-12-31 ( 1007)</a></p><h3>Collections</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Collector</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Practitioner Akerman Philip Prof </a></td></tr></table></div>" ] ; fhir:Specimen.identifier [ fhir:index 0 ; fhir:Identifier.value [ fhir:value "076e1948-2217-11e9-94d8-12e241dc1f66" ] ] ; fhir:Specimen.status [ fhir:value "available"] ; fhir:Specimen.subject [ fhir:Reference.reference [ fhir:value "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d" ] ] ; fhir:Specimen.collection [ fhir:Specimen.collection.collector [ fhir:Reference.reference [ fhir:value "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef" ] ] ] . <urn:uuid:40e85eda-4d31-4bd2-a5a0-c39d63f9824f> a fhir:Observation ; fhir:Resource.id [ fhir:value "Inline-Instance-for-oncologyexamples-r4-withGrouping-4"] ; fhir:Resource.meta [ fhir:Meta.profile [ fhir:value "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-biomarker" ; fhir:index 0 ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-biomarker> ] ] ; fhir:DomainResource.text [ fhir:Narrative.status [ fhir:value "generated" ] ; fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_Inline-Instance-for-oncologyexamples-r4-withGrouping-4\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation Inline-Instance-for-oncologyexamples-r4-withGrouping-4</b></p><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-4\"> </a><a name=\"hcInline-Instance-for-oncologyexamples-r4-withGrouping-4\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-molecular-biomarker.html\">Molecular Biomarker</a></p></div><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs biomarker-category}\">Biomarker Category</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 94076-7}\">Mutations/Megabase [# Ratio] in Tumor</span></p><p><b>subject</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-d0b4affa-91d6-46d1-af01-b30d9f16ef6d\">Carrot John Mr Male, DoB: 1962-12-31 ( 1007)</a></p><p><b>effective</b>: 2023-05-01</p><p><b>performer</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Practitioner Akerman Philip Prof </a></p><p><b>value</b>: 25 somatic variants per megabase of sequenced DNA<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM code1/1000000 = '1/1000000')</span></p><p><b>specimen</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a5d6a6a9-4859-480e-85b2-56974fef3b9d\">Specimen: identifier = 076e1948-2217-11e9-94d8-12e241dc1f66; status = available</a></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs biomarker-category}\">Biomarker Category</span></td><td><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/molecular-biomarker-ontology-cs molgen}\">molecular sequence adjacent category</span></td></tr></table></div>" ] ; fhir:Observation.status [ fhir:value "final"] ; fhir:Observation.category [ fhir:index 0 ; fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/observation-category" ] ; fhir:Coding.code [ fhir:value "laboratory" ] ] ], [ fhir:index 1 ; fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs" ] ; fhir:Coding.code [ fhir:value "biomarker-category" ] ] ], [ fhir:index 2 ; fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/v2-0074" ] ; fhir:Coding.code [ fhir:value "GE" ] ] ] ; fhir:Observation.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:94076-7 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "94076-7" ] ; fhir:Coding.display [ fhir:value "Mutations/Megabase [# Ratio] in Tumor" ] ] ] ; fhir:Observation.subject [ fhir:Reference.reference [ fhir:value "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d" ] ] ; fhir:Observation.effectiveDateTime [ fhir:value "2023-05-01"^^xsd:date] ; fhir:Observation.performer [ fhir:index 0 ; fhir:Reference.reference [ fhir:value "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef" ] ] ; fhir:Observation.valueQuantity [ fhir:Quantity.value [ fhir:value "25"^^xsd:decimal ] ; fhir:Quantity.unit [ fhir:value "somatic variants per megabase of sequenced DNA" ] ; fhir:Quantity.system [ fhir:value "http://unitsofmeasure.org" ] ; fhir:Quantity.code [ fhir:value "1/1000000" ] ] ; fhir:Observation.specimen [ fhir:Reference.reference [ fhir:value "urn:uuid:a5d6a6a9-4859-480e-85b2-56974fef3b9d" ] ] ; fhir:Observation.component [ fhir:index 0 ; fhir:Observation.component.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs" ] ; fhir:Coding.code [ fhir:value "biomarker-category" ] ] ] ; fhir:Observation.component.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/molecular-biomarker-ontology-cs" ] ; fhir:Coding.code [ fhir:value "molgen" ] ; fhir:Coding.display [ fhir:value "molecular sequence adjacent category" ] ] ] ] . <urn:uuid:64b91716-6431-41bd-8fd4-7ac99bebdee9> a fhir:Observation ; fhir:Resource.id [ fhir:value "Inline-Instance-for-oncologyexamples-r4-withGrouping-5"] ; fhir:Resource.meta [ fhir:Meta.profile [ fhir:value "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-biomarker" ; fhir:index 0 ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-biomarker> ] ] ; fhir:DomainResource.text [ fhir:Narrative.status [ fhir:value "generated" ] ; fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_Inline-Instance-for-oncologyexamples-r4-withGrouping-5\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation Inline-Instance-for-oncologyexamples-r4-withGrouping-5</b></p><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-5\"> </a><a name=\"hcInline-Instance-for-oncologyexamples-r4-withGrouping-5\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-molecular-biomarker.html\">Molecular Biomarker</a></p></div><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs biomarker-category}\">Biomarker Category</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81695-9}\">Microsatellite instability [Interpretation] in Cancer specimen Qualitative</span></p><p><b>subject</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-d0b4affa-91d6-46d1-af01-b30d9f16ef6d\">Carrot John Mr Male, DoB: 1962-12-31 ( 1007)</a></p><p><b>effective</b>: 2023-05-01</p><p><b>performer</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Practitioner Akerman Philip Prof </a></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA14122-8}\">Stable</span></p><p><b>specimen</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a5d6a6a9-4859-480e-85b2-56974fef3b9d\">Specimen: identifier = 076e1948-2217-11e9-94d8-12e241dc1f66; status = available</a></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs biomarker-category}\">Biomarker Category</span></td><td><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/molecular-biomarker-ontology-cs molgen}\">molecular sequence adjacent category</span></td></tr></table></div>" ] ; fhir:Observation.status [ fhir:value "final"] ; fhir:Observation.category [ fhir:index 0 ; fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/observation-category" ] ; fhir:Coding.code [ fhir:value "laboratory" ] ] ], [ fhir:index 1 ; fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs" ] ; fhir:Coding.code [ fhir:value "biomarker-category" ] ] ], [ fhir:index 2 ; fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/v2-0074" ] ; fhir:Coding.code [ fhir:value "GE" ] ] ] ; fhir:Observation.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:81695-9 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "81695-9" ] ; fhir:Coding.display [ fhir:value "Microsatellite instability [Interpretation] in Cancer specimen Qualitative" ] ] ] ; fhir:Observation.subject [ fhir:Reference.reference [ fhir:value "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d" ] ] ; fhir:Observation.effectiveDateTime [ fhir:value "2023-05-01"^^xsd:date] ; fhir:Observation.performer [ fhir:index 0 ; fhir:Reference.reference [ fhir:value "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef" ] ] ; fhir:Observation.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:LA14122-8 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "LA14122-8" ] ; fhir:Coding.display [ fhir:value "Stable" ] ] ] ; fhir:Observation.specimen [ fhir:Reference.reference [ fhir:value "urn:uuid:a5d6a6a9-4859-480e-85b2-56974fef3b9d" ] ] ; fhir:Observation.component [ fhir:index 0 ; fhir:Observation.component.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs" ] ; fhir:Coding.code [ fhir:value "biomarker-category" ] ] ] ; fhir:Observation.component.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/molecular-biomarker-ontology-cs" ] ; fhir:Coding.code [ fhir:value "molgen" ] ; fhir:Coding.display [ fhir:value "molecular sequence adjacent category" ] ] ] ] . <urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12d> a fhir:Observation ; fhir:Resource.id [ fhir:value "Inline-Instance-for-oncologyexamples-r4-withGrouping-6"] ; fhir:Resource.meta [ fhir:Meta.profile [ fhir:value "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant" ; fhir:index 0 ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant> ] ] ; fhir:DomainResource.text [ fhir:Narrative.status [ fhir:value "generated" ] ; fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_Inline-Instance-for-oncologyexamples-r4-withGrouping-6\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation Inline-Instance-for-oncologyexamples-r4-withGrouping-6</b></p><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-6\"> </a><a name=\"hcInline-Instance-for-oncologyexamples-r4-withGrouping-6\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-variant.html\">Variant</a></p></div><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></p><p><b>subject</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-d0b4affa-91d6-46d1-af01-b30d9f16ef6d\">Carrot John Mr Male, DoB: 1962-12-31 ( 1007)</a></p><p><b>effective</b>: 2023-05-01</p><p><b>performer</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Practitioner Akerman Philip Prof </a></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26398-0}\">Sequencing</span></p><p><b>specimen</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a5d6a6a9-4859-480e-85b2-56974fef3b9d\">Specimen: identifier = 076e1948-2217-11e9-94d8-12e241dc1f66; status = available</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81290-9}\">Genomic DNA change (gHGVS)</span></p><p><b>value</b>: <span title=\"Codes:{http://varnomen.hgvs.org NC_000009.12:g.5073770G>T}\">NC_000009.12:g.5073770G>T</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48005-3}\">Amino acid change (pHGVS)</span></p><p><b>value</b>: <span title=\"Codes:{http://varnomen.hgvs.org NP_004963.1:p.Val617Phe}\">NP_004963.1:p.Val617Phe</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48002-0}\">Genomic source class</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6683-2}\">Germline</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied ID</span></p><p><b>value</b>: <span title=\"Codes:{http://www.genenames.org JAK2}\">JAK2</span></p></blockquote></div>" ] ; fhir:Observation.status [ fhir:value "final"] ; fhir:Observation.category [ fhir:index 0 ; fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/observation-category" ] ; fhir:Coding.code [ fhir:value "laboratory" ] ] ], [ fhir:index 1 ; fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/v2-0074" ] ; fhir:Coding.code [ fhir:value "GE" ] ] ] ; fhir:Observation.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:69548-6 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "69548-6" ] ; fhir:Coding.display [ fhir:value "Genetic variant assessment" ] ] ] ; fhir:Observation.subject [ fhir:Reference.reference [ fhir:value "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d" ] ] ; fhir:Observation.effectiveDateTime [ fhir:value "2023-05-01"^^xsd:date] ; fhir:Observation.performer [ fhir:index 0 ; fhir:Reference.reference [ fhir:value "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef" ] ] ; fhir:Observation.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:LA9633-4 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "LA9633-4" ] ; fhir:Coding.display [ fhir:value "Present" ] ] ] ; fhir:Observation.method [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:LA26398-0 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "LA26398-0" ] ; fhir:Coding.display [ fhir:value "Sequencing" ] ] ] ; fhir:Observation.specimen [ fhir:Reference.reference [ fhir:value "urn:uuid:a5d6a6a9-4859-480e-85b2-56974fef3b9d" ] ] ; fhir:Observation.component [ fhir:index 0 ; fhir:Observation.component.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:81290-9 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "81290-9" ] ; fhir:Coding.display [ fhir:value "Genomic DNA change (gHGVS)" ] ] ] ; fhir:Observation.component.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://varnomen.hgvs.org" ] ; fhir:Coding.code [ fhir:value "NC_000009.12:g.5073770G>T" ] ; fhir:Coding.display [ fhir:value "NC_000009.12:g.5073770G>T" ] ] ] ], [ fhir:index 1 ; fhir:Observation.component.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:48005-3 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "48005-3" ] ; fhir:Coding.display [ fhir:value "Amino acid change (pHGVS)" ] ] ] ; fhir:Observation.component.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://varnomen.hgvs.org" ] ; fhir:Coding.code [ fhir:value "NP_004963.1:p.Val617Phe" ] ; fhir:Coding.display [ fhir:value "NP_004963.1:p.Val617Phe" ] ] ] ], [ fhir:index 2 ; fhir:Observation.component.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:48002-0 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "48002-0" ] ; fhir:Coding.display [ fhir:value "Genomic source class" ] ] ] ; fhir:Observation.component.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:LA6683-2 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "LA6683-2" ] ; fhir:Coding.display [ fhir:value "Germline" ] ] ] ], [ fhir:index 3 ; fhir:Observation.component.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:48018-6 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "48018-6" ] ; fhir:Coding.display [ fhir:value "Gene studied ID" ] ] ] ; fhir:Observation.component.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://www.genenames.org" ] ; fhir:Coding.code [ fhir:value "JAK2" ] ; fhir:Coding.display [ fhir:value "JAK2" ] ] ] ] . <urn:uuid:772de7d7-e1bd-4183-bdb5-cea8eda317cd> a fhir:Observation ; fhir:Resource.id [ fhir:value "Inline-Instance-for-oncologyexamples-r4-withGrouping-7"] ; fhir:Resource.meta [ fhir:Meta.profile [ fhir:value "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant" ; fhir:index 0 ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant> ] ] ; fhir:DomainResource.text [ fhir:Narrative.status [ fhir:value "generated" ] ; fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_Inline-Instance-for-oncologyexamples-r4-withGrouping-7\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation Inline-Instance-for-oncologyexamples-r4-withGrouping-7</b></p><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-7\"> </a><a name=\"hcInline-Instance-for-oncologyexamples-r4-withGrouping-7\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-variant.html\">Variant</a></p></div><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></p><p><b>subject</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-d0b4affa-91d6-46d1-af01-b30d9f16ef6d\">Carrot John Mr Male, DoB: 1962-12-31 ( 1007)</a></p><p><b>effective</b>: 2023-05-01</p><p><b>performer</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Practitioner Akerman Philip Prof </a></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26398-0}\">Sequencing</span></p><p><b>specimen</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a5d6a6a9-4859-480e-85b2-56974fef3b9d\">Specimen: identifier = 076e1948-2217-11e9-94d8-12e241dc1f66; status = available</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81290-9}\">Genomic DNA change (gHGVS)</span></p><p><b>value</b>: <span title=\"Codes:{http://varnomen.hgvs.org NC_000004.11:g.55972974T>A}\">NC_000004.11:g.55972974T>A</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48005-3}\">Amino acid change (pHGVS)</span></p><p><b>value</b>: <span title=\"Codes:{http://varnomen.hgvs.org NP_002244.1:p.Gln472His}\">NP_002244.1:p.Gln472His</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48002-0}\">Genomic source class</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6683-2}\">Germline</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied ID</span></p><p><b>value</b>: <span title=\"Codes:{http://www.genenames.org KDR}\">KDR</span></p></blockquote></div>" ] ; fhir:Observation.status [ fhir:value "final"] ; fhir:Observation.category [ fhir:index 0 ; fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/observation-category" ] ; fhir:Coding.code [ fhir:value "laboratory" ] ] ], [ fhir:index 1 ; fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/v2-0074" ] ; fhir:Coding.code [ fhir:value "GE" ] ] ] ; fhir:Observation.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:69548-6 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "69548-6" ] ; fhir:Coding.display [ fhir:value "Genetic variant assessment" ] ] ] ; fhir:Observation.subject [ fhir:Reference.reference [ fhir:value "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d" ] ] ; fhir:Observation.effectiveDateTime [ fhir:value "2023-05-01"^^xsd:date] ; fhir:Observation.performer [ fhir:index 0 ; fhir:Reference.reference [ fhir:value "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef" ] ] ; fhir:Observation.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:LA9633-4 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "LA9633-4" ] ; fhir:Coding.display [ fhir:value "Present" ] ] ] ; fhir:Observation.method [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:LA26398-0 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "LA26398-0" ] ; fhir:Coding.display [ fhir:value "Sequencing" ] ] ] ; fhir:Observation.specimen [ fhir:Reference.reference [ fhir:value "urn:uuid:a5d6a6a9-4859-480e-85b2-56974fef3b9d" ] ] ; fhir:Observation.component [ fhir:index 0 ; fhir:Observation.component.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:81290-9 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "81290-9" ] ; fhir:Coding.display [ fhir:value "Genomic DNA change (gHGVS)" ] ] ] ; fhir:Observation.component.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://varnomen.hgvs.org" ] ; fhir:Coding.code [ fhir:value "NC_000004.11:g.55972974T>A" ] ; fhir:Coding.display [ fhir:value "NC_000004.11:g.55972974T>A" ] ] ] ], [ fhir:index 1 ; fhir:Observation.component.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:48005-3 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "48005-3" ] ; fhir:Coding.display [ fhir:value "Amino acid change (pHGVS)" ] ] ] ; fhir:Observation.component.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://varnomen.hgvs.org" ] ; fhir:Coding.code [ fhir:value "NP_002244.1:p.Gln472His" ] ; fhir:Coding.display [ fhir:value "NP_002244.1:p.Gln472His" ] ] ] ], [ fhir:index 2 ; fhir:Observation.component.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:48002-0 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "48002-0" ] ; fhir:Coding.display [ fhir:value "Genomic source class" ] ] ] ; fhir:Observation.component.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:LA6683-2 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "LA6683-2" ] ; fhir:Coding.display [ fhir:value "Germline" ] ] ] ], [ fhir:index 3 ; fhir:Observation.component.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:48018-6 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "48018-6" ] ; fhir:Coding.display [ fhir:value "Gene studied ID" ] ] ] ; fhir:Observation.component.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://www.genenames.org" ] ; fhir:Coding.code [ fhir:value "KDR" ] ; fhir:Coding.display [ fhir:value "KDR" ] ] ] ] . <urn:uuid:b33eb7ec-d83e-49d2-b0f3-729d024ebe01> a fhir:Observation ; fhir:Resource.id [ fhir:value "Inline-Instance-for-oncologyexamples-r4-withGrouping-8"] ; fhir:Resource.meta [ fhir:Meta.profile [ fhir:value "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant" ; fhir:index 0 ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant> ] ] ; fhir:DomainResource.text [ fhir:Narrative.status [ fhir:value "generated" ] ; fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_Inline-Instance-for-oncologyexamples-r4-withGrouping-8\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation Inline-Instance-for-oncologyexamples-r4-withGrouping-8</b></p><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-8\"> </a><a name=\"hcInline-Instance-for-oncologyexamples-r4-withGrouping-8\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-variant.html\">Variant</a></p></div><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></p><p><b>subject</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-d0b4affa-91d6-46d1-af01-b30d9f16ef6d\">Carrot John Mr Male, DoB: 1962-12-31 ( 1007)</a></p><p><b>effective</b>: 2023-05-01</p><p><b>performer</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Practitioner Akerman Philip Prof </a></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26398-0}\">Sequencing</span></p><p><b>specimen</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a5d6a6a9-4859-480e-85b2-56974fef3b9d\">Specimen: identifier = 076e1948-2217-11e9-94d8-12e241dc1f66; status = available</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81290-9}\">Genomic DNA change (gHGVS)</span></p><p><b>value</b>: <span title=\"Codes:{http://varnomen.hgvs.org NC_000002.12:g.211713666_211713668del}\">NC_000002.12:g.211713666_211713668del</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48002-0}\">Genomic source class</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6683-2}\">Germline</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied ID</span></p><p><b>value</b>: <span title=\"Codes:{http://www.genenames.org ERBB4}\">ERBB4</span></p></blockquote></div>" ] ; fhir:Observation.status [ fhir:value "final"] ; fhir:Observation.category [ fhir:index 0 ; fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/observation-category" ] ; fhir:Coding.code [ fhir:value "laboratory" ] ] ], [ fhir:index 1 ; fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/v2-0074" ] ; fhir:Coding.code [ fhir:value "GE" ] ] ] ; fhir:Observation.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:69548-6 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "69548-6" ] ; fhir:Coding.display [ fhir:value "Genetic variant assessment" ] ] ] ; fhir:Observation.subject [ fhir:Reference.reference [ fhir:value "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d" ] ] ; fhir:Observation.effectiveDateTime [ fhir:value "2023-05-01"^^xsd:date] ; fhir:Observation.performer [ fhir:index 0 ; fhir:Reference.reference [ fhir:value "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef" ] ] ; fhir:Observation.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:LA9633-4 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "LA9633-4" ] ; fhir:Coding.display [ fhir:value "Present" ] ] ] ; fhir:Observation.method [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:LA26398-0 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "LA26398-0" ] ; fhir:Coding.display [ fhir:value "Sequencing" ] ] ] ; fhir:Observation.specimen [ fhir:Reference.reference [ fhir:value "urn:uuid:a5d6a6a9-4859-480e-85b2-56974fef3b9d" ] ] ; fhir:Observation.component [ fhir:index 0 ; fhir:Observation.component.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:81290-9 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "81290-9" ] ; fhir:Coding.display [ fhir:value "Genomic DNA change (gHGVS)" ] ] ] ; fhir:Observation.component.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://varnomen.hgvs.org" ] ; fhir:Coding.code [ fhir:value "NC_000002.12:g.211713666_211713668del" ] ; fhir:Coding.display [ fhir:value "NC_000002.12:g.211713666_211713668del" ] ] ] ], [ fhir:index 1 ; fhir:Observation.component.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:48002-0 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "48002-0" ] ; fhir:Coding.display [ fhir:value "Genomic source class" ] ] ] ; fhir:Observation.component.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:LA6683-2 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "LA6683-2" ] ; fhir:Coding.display [ fhir:value "Germline" ] ] ] ], [ fhir:index 2 ; fhir:Observation.component.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:48018-6 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "48018-6" ] ; fhir:Coding.display [ fhir:value "Gene studied ID" ] ] ] ; fhir:Observation.component.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://www.genenames.org" ] ; fhir:Coding.code [ fhir:value "ERBB4" ] ; fhir:Coding.display [ fhir:value "ERBB4" ] ] ] ] . <urn:uuid:1bf9642d-fd1c-4819-8c5d-44fae4bad524> a fhir:Observation ; fhir:Resource.id [ fhir:value "Inline-Instance-for-oncologyexamples-r4-withGrouping-9"] ; fhir:Resource.meta [ fhir:Meta.profile [ fhir:value "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication" ; fhir:index 0 ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication> ] ] ; fhir:DomainResource.text [ fhir:Narrative.status [ fhir:value "extensions" ] ; fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_Inline-Instance-for-oncologyexamples-r4-withGrouping-9\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation Inline-Instance-for-oncologyexamples-r4-withGrouping-9</b></p><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-9\"> </a><a name=\"hcInline-Instance-for-oncologyexamples-r4-withGrouping-9\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-therapeutic-implication.html\">Therapeutic Implication</a></p></div><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></p><p><b>subject</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-d0b4affa-91d6-46d1-af01-b30d9f16ef6d\">Carrot John Mr Male, DoB: 1962-12-31 ( 1007)</a></p><p><b>effective</b>: 2023-05-01</p><p><b>performer</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Practitioner Akerman Philip Prof </a></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26811-2}\">Computational analysis</span></p><p><b>specimen</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a5d6a6a9-4859-480e-85b2-56974fef3b9d\">Specimen: identifier = 076e1948-2217-11e9-94d8-12e241dc1f66; status = available</a></p><p><b>derivedFrom</b>: <a href=\"Bundle-bundle-complexVariant-nonHGVS.html#urn-uuid-16fdd5fc-e665-48af-99e4-48d603f3e12d\">Observation Genetic variant assessment</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6677-4}\">Responsive</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 93044-6}\">Level of evidence</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA30200-2}\">Very strong evidence pathogenic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81259-4}\">Associated phenotype</span></p><p><b>value</b>: <span title=\"Codes:\">Polycythemia vera (PV)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>Medication Assessed reference to a FHIR resource</b>: <a href=\"#hcInline-Instance-for-oncologyexamples-r4-withGrouping-9/Inline-MedicationKnowledgeRuxolitinib\">MedicationKnowledge Ruxolitinib</a></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 51963-7}\">Medication assessed [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.nlm.nih.gov/research/umls/rxnorm 1193326}\">Ruxolitinib</span></p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: MedicationKnowledge #Inline-MedicationKnowledgeRuxolitinib</b></p><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-9/Inline-MedicationKnowledgeRuxolitinib\"> </a><a name=\"hcInline-Instance-for-oncologyexamples-r4-withGrouping-9/Inline-MedicationKnowledgeRuxolitinib\"> </a><p><b>code</b>: <span title=\"Codes:{http://www.nlm.nih.gov/research/umls/rxnorm 1193326}\">Ruxolitinib</span></p><p><b>status</b>: Active</p></blockquote></div>" ] ; fhir:DomainResource.contained [ a fhir:MedicationKnowledge ; fhir:index 0 ; fhir:Resource.id [ fhir:value "Inline-MedicationKnowledgeRuxolitinib" ] ; fhir:MedicationKnowledge.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://www.nlm.nih.gov/research/umls/rxnorm" ] ; fhir:Coding.code [ fhir:value "1193326" ] ; fhir:Coding.display [ fhir:value "Ruxolitinib" ] ] ] ; fhir:MedicationKnowledge.status [ fhir:value "active" ] ] ; fhir:Observation.status [ fhir:value "final"] ; fhir:Observation.category [ fhir:index 0 ; fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/observation-category" ] ; fhir:Coding.code [ fhir:value "laboratory" ] ] ], [ fhir:index 1 ; fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/v2-0074" ] ; fhir:Coding.code [ fhir:value "GE" ] ] ] ; fhir:Observation.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs" ] ; fhir:Coding.code [ fhir:value "therapeutic-implication" ] ; fhir:Coding.display [ fhir:value "Therapeutic Implication" ] ] ] ; fhir:Observation.subject [ fhir:Reference.reference [ fhir:value "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d" ] ] ; fhir:Observation.effectiveDateTime [ fhir:value "2023-05-01"^^xsd:date] ; fhir:Observation.performer [ fhir:index 0 ; fhir:Reference.reference [ fhir:value "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef" ] ] ; fhir:Observation.method [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:LA26811-2 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "LA26811-2" ] ; fhir:Coding.display [ fhir:value "Computational analysis" ] ] ] ; fhir:Observation.specimen [ fhir:Reference.reference [ fhir:value "urn:uuid:a5d6a6a9-4859-480e-85b2-56974fef3b9d" ] ] ; fhir:Observation.derivedFrom [ fhir:index 0 ; fhir:Reference.reference [ fhir:value "urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12d" ] ] ; fhir:Observation.component [ fhir:index 0 ; fhir:Observation.component.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs" ] ; fhir:Coding.code [ fhir:value "therapeutic-implication" ] ] ] ; fhir:Observation.component.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:LA6677-4 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "LA6677-4" ] ; fhir:Coding.display [ fhir:value "Responsive" ] ] ] ], [ fhir:index 1 ; fhir:Observation.component.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:93044-6 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "93044-6" ] ] ] ; fhir:Observation.component.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:LA30200-2 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "LA30200-2" ] ; fhir:Coding.display [ fhir:value "Very strong evidence pathogenic" ] ] ] ], [ fhir:index 2 ; fhir:Observation.component.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:81259-4 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "81259-4" ] ] ] ; fhir:Observation.component.valueCodeableConcept [ fhir:CodeableConcept.text [ fhir:value "Polycythemia vera (PV)" ] ] ], [ fhir:index 3 ; fhir:Element.extension [ fhir:index 0 ; fhir:Extension.url [ fhir:value "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/medication-assessed-reference" ] ; fhir:Extension.valueReference [ fhir:Reference.reference [ fhir:value "#Inline-MedicationKnowledgeRuxolitinib" ] ] ] ; fhir:Observation.component.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:51963-7 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "51963-7" ] ] ] ; fhir:Observation.component.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://www.nlm.nih.gov/research/umls/rxnorm" ] ; fhir:Coding.code [ fhir:value "1193326" ] ; fhir:Coding.display [ fhir:value "Ruxolitinib" ] ] ] ] . <urn:uuid:1301943b-55db-4adf-8355-3635f7268a1b> a fhir:Observation ; fhir:Resource.id [ fhir:value "Inline-Instance-for-oncologyexamples-r4-withGrouping-10"] ; fhir:Resource.meta [ fhir:Meta.profile [ fhir:value "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication" ; fhir:index 0 ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication> ] ] ; fhir:DomainResource.text [ fhir:Narrative.status [ fhir:value "generated" ] ; fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_Inline-Instance-for-oncologyexamples-r4-withGrouping-10\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation Inline-Instance-for-oncologyexamples-r4-withGrouping-10</b></p><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-10\"> </a><a name=\"hcInline-Instance-for-oncologyexamples-r4-withGrouping-10\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-therapeutic-implication.html\">Therapeutic Implication</a></p></div><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></p><p><b>subject</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-d0b4affa-91d6-46d1-af01-b30d9f16ef6d\">Carrot John Mr Male, DoB: 1962-12-31 ( 1007)</a></p><p><b>effective</b>: 2023-05-01</p><p><b>performer</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Practitioner Akerman Philip Prof </a></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26811-2}\">Computational analysis</span></p><p><b>specimen</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a5d6a6a9-4859-480e-85b2-56974fef3b9d\">Specimen: identifier = 076e1948-2217-11e9-94d8-12e241dc1f66; status = available</a></p><p><b>derivedFrom</b>: <a href=\"Bundle-bundle-complexVariant-nonHGVS.html#urn-uuid-16fdd5fc-e665-48af-99e4-48d603f3e12d\">Observation Genetic variant assessment</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6677-4}\">Responsive</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 93044-6}\">Level of Evidence</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA30200-2}\">Very strong evidence pathogenic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81259-4}\">Associated phenotype</span></p><p><b>value</b>: <span title=\"Codes:\">Polycythemia vera (PV)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 51963-7}\">Medication assessed</span></p><p><b>value</b>: <span title=\"Codes:\">AT9283</span></p></blockquote></div>" ] ; fhir:Observation.status [ fhir:value "final"] ; fhir:Observation.category [ fhir:index 0 ; fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/observation-category" ] ; fhir:Coding.code [ fhir:value "laboratory" ] ] ], [ fhir:index 1 ; fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/v2-0074" ] ; fhir:Coding.code [ fhir:value "GE" ] ] ] ; fhir:Observation.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs" ] ; fhir:Coding.code [ fhir:value "therapeutic-implication" ] ; fhir:Coding.display [ fhir:value "Therapeutic Implication" ] ] ] ; fhir:Observation.subject [ fhir:Reference.reference [ fhir:value "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d" ] ] ; fhir:Observation.effectiveDateTime [ fhir:value "2023-05-01"^^xsd:date] ; fhir:Observation.performer [ fhir:index 0 ; fhir:Reference.reference [ fhir:value "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef" ] ] ; fhir:Observation.method [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:LA26811-2 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "LA26811-2" ] ; fhir:Coding.display [ fhir:value "Computational analysis" ] ] ] ; fhir:Observation.specimen [ fhir:Reference.reference [ fhir:value "urn:uuid:a5d6a6a9-4859-480e-85b2-56974fef3b9d" ] ] ; fhir:Observation.derivedFrom [ fhir:index 0 ; fhir:Reference.reference [ fhir:value "urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12d" ] ] ; fhir:Observation.component [ fhir:index 0 ; fhir:Observation.component.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs" ] ; fhir:Coding.code [ fhir:value "therapeutic-implication" ] ] ] ; fhir:Observation.component.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:LA6677-4 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "LA6677-4" ] ; fhir:Coding.display [ fhir:value "Responsive" ] ] ] ], [ fhir:index 1 ; fhir:Observation.component.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:93044-6 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "93044-6" ] ; fhir:Coding.display [ fhir:value "Level of Evidence" ] ] ] ; fhir:Observation.component.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:LA30200-2 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "LA30200-2" ] ; fhir:Coding.display [ fhir:value "Very strong evidence pathogenic" ] ] ] ], [ fhir:index 2 ; fhir:Observation.component.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:81259-4 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "81259-4" ] ] ] ; fhir:Observation.component.valueCodeableConcept [ fhir:CodeableConcept.text [ fhir:value "Polycythemia vera (PV)" ] ] ], [ fhir:index 3 ; fhir:Observation.component.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:51963-7 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "51963-7" ] ; fhir:Coding.display [ fhir:value "Medication assessed" ] ] ] ; fhir:Observation.component.valueCodeableConcept [ fhir:CodeableConcept.text [ fhir:value "AT9283" ] ] ] . <urn:uuid:05713d1c-0df5-46d5-a5a9-2085eef56c20> a fhir:Observation ; fhir:Resource.id [ fhir:value "Inline-Instance-for-oncologyexamples-r4-withGrouping-11"] ; fhir:Resource.meta [ fhir:Meta.profile [ fhir:value "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication" ; fhir:index 0 ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication> ] ] ; fhir:DomainResource.text [ fhir:Narrative.status [ fhir:value "generated" ] ; fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_Inline-Instance-for-oncologyexamples-r4-withGrouping-11\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation Inline-Instance-for-oncologyexamples-r4-withGrouping-11</b></p><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-11\"> </a><a name=\"hcInline-Instance-for-oncologyexamples-r4-withGrouping-11\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-therapeutic-implication.html\">Therapeutic Implication</a></p></div><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></p><p><b>subject</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-d0b4affa-91d6-46d1-af01-b30d9f16ef6d\">Carrot John Mr Male, DoB: 1962-12-31 ( 1007)</a></p><p><b>effective</b>: 2023-05-01</p><p><b>performer</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Practitioner Akerman Philip Prof </a></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26811-2}\">Computational analysis</span></p><p><b>specimen</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a5d6a6a9-4859-480e-85b2-56974fef3b9d\">Specimen: identifier = 076e1948-2217-11e9-94d8-12e241dc1f66; status = available</a></p><p><b>derivedFrom</b>: <a href=\"Bundle-bundle-complexVariant-nonHGVS.html#urn-uuid-16fdd5fc-e665-48af-99e4-48d603f3e12d\">Observation Genetic variant assessment</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6677-4}\">Responsive</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 93044-6}\">Level of Evidence</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA30200-2}\">Very strong evidence pathogenic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81259-4}\">Associated phenotype</span></p><p><b>value</b>: <span title=\"Codes:\">Polycythemia vera (PV)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 51963-7}\">Medication assessed</span></p><p><b>value</b>: <span title=\"Codes:\">SNX-5422</span></p></blockquote></div>" ] ; fhir:Observation.status [ fhir:value "final"] ; fhir:Observation.category [ fhir:index 0 ; fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/observation-category" ] ; fhir:Coding.code [ fhir:value "laboratory" ] ] ], [ fhir:index 1 ; fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/v2-0074" ] ; fhir:Coding.code [ fhir:value "GE" ] ] ] ; fhir:Observation.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs" ] ; fhir:Coding.code [ fhir:value "therapeutic-implication" ] ; fhir:Coding.display [ fhir:value "Therapeutic Implication" ] ] ] ; fhir:Observation.subject [ fhir:Reference.reference [ fhir:value "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d" ] ] ; fhir:Observation.effectiveDateTime [ fhir:value "2023-05-01"^^xsd:date] ; fhir:Observation.performer [ fhir:index 0 ; fhir:Reference.reference [ fhir:value "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef" ] ] ; fhir:Observation.method [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:LA26811-2 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "LA26811-2" ] ; fhir:Coding.display [ fhir:value "Computational analysis" ] ] ] ; fhir:Observation.specimen [ fhir:Reference.reference [ fhir:value "urn:uuid:a5d6a6a9-4859-480e-85b2-56974fef3b9d" ] ] ; fhir:Observation.derivedFrom [ fhir:index 0 ; fhir:Reference.reference [ fhir:value "urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12d" ] ] ; fhir:Observation.component [ fhir:index 0 ; fhir:Observation.component.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs" ] ; fhir:Coding.code [ fhir:value "therapeutic-implication" ] ] ] ; fhir:Observation.component.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:LA6677-4 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "LA6677-4" ] ; fhir:Coding.display [ fhir:value "Responsive" ] ] ] ], [ fhir:index 1 ; fhir:Observation.component.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:93044-6 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "93044-6" ] ; fhir:Coding.display [ fhir:value "Level of Evidence" ] ] ] ; fhir:Observation.component.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:LA30200-2 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "LA30200-2" ] ; fhir:Coding.display [ fhir:value "Very strong evidence pathogenic" ] ] ] ], [ fhir:index 2 ; fhir:Observation.component.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:81259-4 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "81259-4" ] ] ] ; fhir:Observation.component.valueCodeableConcept [ fhir:CodeableConcept.text [ fhir:value "Polycythemia vera (PV)" ] ] ], [ fhir:index 3 ; fhir:Observation.component.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:51963-7 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "51963-7" ] ; fhir:Coding.display [ fhir:value "Medication assessed" ] ] ] ; fhir:Observation.component.valueCodeableConcept [ fhir:CodeableConcept.text [ fhir:value "SNX-5422" ] ] ] . <urn:uuid:294f1401-e2eb-4df1-b6d2-09e1b7a6eca4> a fhir:Observation ; fhir:Resource.id [ fhir:value "Inline-Instance-for-oncologyexamples-r4-withGrouping-12"] ; fhir:Resource.meta [ fhir:Meta.profile [ fhir:value "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication" ; fhir:index 0 ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication> ] ] ; fhir:DomainResource.text [ fhir:Narrative.status [ fhir:value "generated" ] ; fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_Inline-Instance-for-oncologyexamples-r4-withGrouping-12\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation Inline-Instance-for-oncologyexamples-r4-withGrouping-12</b></p><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-12\"> </a><a name=\"hcInline-Instance-for-oncologyexamples-r4-withGrouping-12\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-therapeutic-implication.html\">Therapeutic Implication</a></p></div><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></p><p><b>subject</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-d0b4affa-91d6-46d1-af01-b30d9f16ef6d\">Carrot John Mr Male, DoB: 1962-12-31 ( 1007)</a></p><p><b>effective</b>: 2023-05-01</p><p><b>performer</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Practitioner Akerman Philip Prof </a></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26811-2}\">Computational analysis</span></p><p><b>specimen</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a5d6a6a9-4859-480e-85b2-56974fef3b9d\">Specimen: identifier = 076e1948-2217-11e9-94d8-12e241dc1f66; status = available</a></p><p><b>derivedFrom</b>: <a href=\"Bundle-bundle-complexVariant-nonHGVS.html#urn-uuid-16fdd5fc-e665-48af-99e4-48d603f3e12d\">Observation Genetic variant assessment</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6677-4}\">Responsive</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 93044-6}\">Level of Evidence</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA30200-2}\">Very strong evidence pathogenic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81259-4}\">Associated phenotype</span></p><p><b>value</b>: <span title=\"Codes:\">Polycythemia vera (PV)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 51963-7}\">Medication assessed</span></p><p><b>value</b>: <span title=\"Codes:\">TG02</span></p></blockquote></div>" ] ; fhir:Observation.status [ fhir:value "final"] ; fhir:Observation.category [ fhir:index 0 ; fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/observation-category" ] ; fhir:Coding.code [ fhir:value "laboratory" ] ] ], [ fhir:index 1 ; fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/v2-0074" ] ; fhir:Coding.code [ fhir:value "GE" ] ] ] ; fhir:Observation.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs" ] ; fhir:Coding.code [ fhir:value "therapeutic-implication" ] ; fhir:Coding.display [ fhir:value "Therapeutic Implication" ] ] ] ; fhir:Observation.subject [ fhir:Reference.reference [ fhir:value "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d" ] ] ; fhir:Observation.effectiveDateTime [ fhir:value "2023-05-01"^^xsd:date] ; fhir:Observation.performer [ fhir:index 0 ; fhir:Reference.reference [ fhir:value "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef" ] ] ; fhir:Observation.method [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:LA26811-2 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "LA26811-2" ] ; fhir:Coding.display [ fhir:value "Computational analysis" ] ] ] ; fhir:Observation.specimen [ fhir:Reference.reference [ fhir:value "urn:uuid:a5d6a6a9-4859-480e-85b2-56974fef3b9d" ] ] ; fhir:Observation.derivedFrom [ fhir:index 0 ; fhir:Reference.reference [ fhir:value "urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12d" ] ] ; fhir:Observation.component [ fhir:index 0 ; fhir:Observation.component.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs" ] ; fhir:Coding.code [ fhir:value "therapeutic-implication" ] ] ] ; fhir:Observation.component.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:LA6677-4 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "LA6677-4" ] ; fhir:Coding.display [ fhir:value "Responsive" ] ] ] ], [ fhir:index 1 ; fhir:Observation.component.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:93044-6 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "93044-6" ] ; fhir:Coding.display [ fhir:value "Level of Evidence" ] ] ] ; fhir:Observation.component.valueCodeableConcept [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:LA30200-2 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "LA30200-2" ] ; fhir:Coding.display [ fhir:value "Very strong evidence pathogenic" ] ] ] ], [ fhir:index 2 ; fhir:Observation.component.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:81259-4 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "81259-4" ] ] ] ; fhir:Observation.component.valueCodeableConcept [ fhir:CodeableConcept.text [ fhir:value "Polycythemia vera (PV)" ] ] ], [ fhir:index 3 ; fhir:Observation.component.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:51963-7 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "51963-7" ] ; fhir:Coding.display [ fhir:value "Medication assessed" ] ] ] ; fhir:Observation.component.valueCodeableConcept [ fhir:CodeableConcept.text [ fhir:value "TG02" ] ] ] . <urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12f> a fhir:Observation ; fhir:Resource.id [ fhir:value "Inline-Instance-for-oncologyexamples-r4-withGrouping-13"] ; fhir:DomainResource.text [ fhir:Narrative.status [ fhir:value "generated" ] ; fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_Inline-Instance-for-oncologyexamples-r4-withGrouping-13\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation Inline-Instance-for-oncologyexamples-r4-withGrouping-13</b></p><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-13\"> </a><a name=\"hcInline-Instance-for-oncologyexamples-r4-withGrouping-13\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C43359}\">Group</span></p><p><b>subject</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-d0b4affa-91d6-46d1-af01-b30d9f16ef6d\">Carrot John Mr Male, DoB: 1962-12-31 ( 1007)</a></p><p><b>effective</b>: 2023-05-01</p><p><b>performer</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Practitioner Akerman Philip Prof </a></p><p><b>hasMember</b>: </p><ul><li><a href=\"Bundle-bundle-complexVariant-nonHGVS.html#urn-uuid-16fdd5fc-e665-48af-99e4-48d603f3e12d\">SNV analysis for JAK2 variant</a></li><li><a href=\"Bundle-bundle-oncologyexamples-r4-withGrouping.html#urn-uuid-772de7d7-e1bd-4183-bdb5-cea8eda317cd\">SNV analysis for KDR variant</a></li><li><a href=\"Bundle-bundle-oncologyexamples-r4-withGrouping.html#urn-uuid-b33eb7ec-d83e-49d2-b0f3-729d024ebe01\">SNV analysis for ERBB4 variant</a></li><li><a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-40e85eda-4d31-4bd2-a5a0-c39d63f9824f\">TMB value analysis</a></li><li><a href=\"Bundle-bundle-oncologyexamples-r4-withGrouping.html#urn-uuid-64b91716-6431-41bd-8fd4-7ac99bebdee9\">MSI status analysis</a></li></ul></div>" ] ; fhir:Observation.status [ fhir:value "final"] ; fhir:Observation.category [ fhir:index 0 ; fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/observation-category" ] ; fhir:Coding.code [ fhir:value "laboratory" ] ] ], [ fhir:index 1 ; fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/v2-0074" ] ; fhir:Coding.code [ fhir:value "GE" ] ] ] ; fhir:Observation.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl" ] ; fhir:Coding.code [ fhir:value "C43359" ] ; fhir:Coding.display [ fhir:value "Group" ] ] ] ; fhir:Observation.subject [ fhir:Reference.reference [ fhir:value "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d" ] ] ; fhir:Observation.effectiveDateTime [ fhir:value "2023-05-01"^^xsd:date] ; fhir:Observation.performer [ fhir:index 0 ; fhir:Reference.reference [ fhir:value "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef" ] ] ; fhir:Observation.hasMember [ fhir:index 0 ; fhir:Reference.reference [ fhir:value "urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12d" ] ; fhir:Reference.display [ fhir:value "SNV analysis for JAK2 variant" ] ], [ fhir:index 1 ; fhir:Reference.reference [ fhir:value "urn:uuid:772de7d7-e1bd-4183-bdb5-cea8eda317cd" ] ; fhir:Reference.display [ fhir:value "SNV analysis for KDR variant" ] ], [ fhir:index 2 ; fhir:Reference.reference [ fhir:value "urn:uuid:b33eb7ec-d83e-49d2-b0f3-729d024ebe01" ] ; fhir:Reference.display [ fhir:value "SNV analysis for ERBB4 variant" ] ], [ fhir:index 3 ; fhir:Reference.reference [ fhir:value "urn:uuid:40e85eda-4d31-4bd2-a5a0-c39d63f9824f" ] ; fhir:Reference.display [ fhir:value "TMB value analysis" ] ], [ fhir:index 4 ; fhir:Reference.reference [ fhir:value "urn:uuid:64b91716-6431-41bd-8fd4-7ac99bebdee9" ] ; fhir:Reference.display [ fhir:value "MSI status analysis" ] ] . <urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12e> a fhir:Observation ; fhir:Resource.id [ fhir:value "Inline-Instance-for-oncologyexamples-r4-withGrouping-14"] ; fhir:DomainResource.text [ fhir:Narrative.status [ fhir:value "generated" ] ; fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_Inline-Instance-for-oncologyexamples-r4-withGrouping-14\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation Inline-Instance-for-oncologyexamples-r4-withGrouping-14</b></p><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-14\"> </a><a name=\"hcInline-Instance-for-oncologyexamples-r4-withGrouping-14\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C43359}\">Group</span></p><p><b>subject</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-d0b4affa-91d6-46d1-af01-b30d9f16ef6d\">Carrot John Mr Male, DoB: 1962-12-31 ( 1007)</a></p><p><b>effective</b>: 2023-05-01</p><p><b>performer</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Practitioner Akerman Philip Prof </a></p><p><b>hasMember</b>: </p><ul><li><a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-1bf9642d-fd1c-4819-8c5d-44fae4bad524\">Therapy match result 1</a></li><li><a href=\"Bundle-bundle-oncologyexamples-r4-withGrouping.html#urn-uuid-1301943b-55db-4adf-8355-3635f7268a1b\">Therapy match result 2</a></li><li><a href=\"Bundle-bundle-oncologyexamples-r4-withGrouping.html#urn-uuid-05713d1c-0df5-46d5-a5a9-2085eef56c20\">Therapy match result 3</a></li><li><a href=\"Bundle-bundle-oncologyexamples-r4-withGrouping.html#urn-uuid-294f1401-e2eb-4df1-b6d2-09e1b7a6eca4\">Therapy match result 4</a></li></ul></div>" ] ; fhir:Observation.status [ fhir:value "final"] ; fhir:Observation.category [ fhir:index 0 ; fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/observation-category" ] ; fhir:Coding.code [ fhir:value "laboratory" ] ] ], [ fhir:index 1 ; fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/v2-0074" ] ; fhir:Coding.code [ fhir:value "GE" ] ] ] ; fhir:Observation.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl" ] ; fhir:Coding.code [ fhir:value "C43359" ] ; fhir:Coding.display [ fhir:value "Group" ] ] ] ; fhir:Observation.subject [ fhir:Reference.reference [ fhir:value "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d" ] ] ; fhir:Observation.effectiveDateTime [ fhir:value "2023-05-01"^^xsd:date] ; fhir:Observation.performer [ fhir:index 0 ; fhir:Reference.reference [ fhir:value "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef" ] ] ; fhir:Observation.hasMember [ fhir:index 0 ; fhir:Reference.reference [ fhir:value "urn:uuid:1bf9642d-fd1c-4819-8c5d-44fae4bad524" ] ; fhir:Reference.display [ fhir:value "Therapy match result 1" ] ], [ fhir:index 1 ; fhir:Reference.reference [ fhir:value "urn:uuid:1301943b-55db-4adf-8355-3635f7268a1b" ] ; fhir:Reference.display [ fhir:value "Therapy match result 2" ] ], [ fhir:index 2 ; fhir:Reference.reference [ fhir:value "urn:uuid:05713d1c-0df5-46d5-a5a9-2085eef56c20" ] ; fhir:Reference.display [ fhir:value "Therapy match result 3" ] ], [ fhir:index 3 ; fhir:Reference.reference [ fhir:value "urn:uuid:294f1401-e2eb-4df1-b6d2-09e1b7a6eca4" ] ; fhir:Reference.display [ fhir:value "Therapy match result 4" ] ] . <urn:uuid:ad7a499b-a43b-4cc8-bf46-cac62d9ecae5> a fhir:DiagnosticReport ; fhir:Resource.id [ fhir:value "Inline-Instance-for-oncologyexamples-r4-withGrouping-15"] ; fhir:Resource.meta [ fhir:Meta.profile [ fhir:value "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-report" ; fhir:index 0 ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-report> ] ] ; fhir:DomainResource.text [ fhir:Narrative.status [ fhir:value "generated" ] ; fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"DiagnosticReport_Inline-Instance-for-oncologyexamples-r4-withGrouping-15\"> </a><p class=\"res-header-id\"><b>Generated Narrative: DiagnosticReport Inline-Instance-for-oncologyexamples-r4-withGrouping-15</b></p><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-15\"> </a><a name=\"hcInline-Instance-for-oncologyexamples-r4-withGrouping-15\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-genomic-report.html\">Genomic Report</a></p></div><h2><span title=\"Codes:{http://loinc.org 51969-4}\">Genetic analysis report</span> (<span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span>) </h2><table class=\"grid\"><tr><td>Subject</td><td>Carrot John Mr Male, DoB: 1962-12-31 ( 1007)</td></tr><tr><td>Performer</td><td> <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Practitioner Akerman Philip Prof </a></td></tr></table><p><b>Report Details</b></p><table class=\"grid\"><tr><td><b>Code</b></td><td><b>Value</b></td><td><b>Flags</b></td><td><b>Relevant Time</b></td><td><b>Reported</b></td></tr><tr><td><a href=\"Bundle-bundle-oncologyexamples-r4-withGrouping.html#urn-uuid-16fdd5fc-e665-48af-99e4-48d603f3e12f\"><span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C43359}\">Group</span></a></td><td/><td>Final</td><td>2023-05-01</td><td/></tr><tr><td><a href=\"Bundle-bundle-complexVariant-nonHGVS.html#urn-uuid-16fdd5fc-e665-48af-99e4-48d603f3e12d\"><span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></a></td><td><span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></td><td>Final</td><td>2019-03-05</td><td>2019-03-05 16:04:44+0000</td></tr><tr><td><a href=\"Bundle-bundle-oncologyexamples-r4-withGrouping.html#urn-uuid-772de7d7-e1bd-4183-bdb5-cea8eda317cd\"><span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></a></td><td><span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></td><td>Final</td><td>2023-05-01</td><td/></tr><tr><td><a href=\"Bundle-bundle-oncologyexamples-r4-withGrouping.html#urn-uuid-b33eb7ec-d83e-49d2-b0f3-729d024ebe01\"><span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></a></td><td><span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></td><td>Final</td><td>2023-05-01</td><td/></tr><tr><td><a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-40e85eda-4d31-4bd2-a5a0-c39d63f9824f\"><span title=\"Codes:{http://loinc.org 94076-7}\">Mutations/Megabase [# Ratio] in Tumor</span></a></td><td>25 Mutations/Megabase<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM code1/1000000 = '1/1000000')</span></td><td>Final</td><td>2019-03-05</td><td/></tr><tr><td><a href=\"Bundle-bundle-oncologyexamples-r4-withGrouping.html#urn-uuid-64b91716-6431-41bd-8fd4-7ac99bebdee9\"><span title=\"Codes:{http://loinc.org 81695-9}\">Microsatellite instability [Interpretation] in Cancer specimen Qualitative</span></a></td><td><span title=\"Codes:{http://loinc.org LA14122-8}\">Stable</span></td><td>Final</td><td>2023-05-01</td><td/></tr><tr><td><a href=\"Bundle-bundle-complexVariant-nonHGVS.html#urn-uuid-16fdd5fc-e665-48af-99e4-48d603f3e12e\"><span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></a></td><td><span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></td><td>Final</td><td>2019-03-05</td><td>2019-03-05 16:04:44+0000</td></tr><tr><td><a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-1bf9642d-fd1c-4819-8c5d-44fae4bad524\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}\">Diagnostic Implication</span></a></td><td/><td>Final</td><td>2019-03-05</td><td/></tr><tr><td><a href=\"Bundle-bundle-oncologyexamples-r4-withGrouping.html#urn-uuid-1301943b-55db-4adf-8355-3635f7268a1b\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></a></td><td/><td>Final</td><td>2023-05-01</td><td/></tr><tr><td><a href=\"Bundle-bundle-oncologyexamples-r4-withGrouping.html#urn-uuid-05713d1c-0df5-46d5-a5a9-2085eef56c20\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></a></td><td/><td>Final</td><td>2023-05-01</td><td/></tr><tr><td><a href=\"Bundle-bundle-oncologyexamples-r4-withGrouping.html#urn-uuid-294f1401-e2eb-4df1-b6d2-09e1b7a6eca4\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></a></td><td/><td>Final</td><td>2023-05-01</td><td/></tr></table></div>" ] ; fhir:DiagnosticReport.status [ fhir:value "final"] ; fhir:DiagnosticReport.category [ fhir:index 0 ; fhir:CodeableConcept.coding [ fhir:index 0 ; fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/v2-0074" ] ; fhir:Coding.code [ fhir:value "GE" ] ] ] ; fhir:DiagnosticReport.code [ fhir:CodeableConcept.coding [ fhir:index 0 ; a loinc:51969-4 ; fhir:Coding.system [ fhir:value "http://loinc.org" ] ; fhir:Coding.code [ fhir:value "51969-4" ] ] ; fhir:CodeableConcept.text [ fhir:value "Genetic analysis report" ] ] ; fhir:DiagnosticReport.subject [ fhir:Reference.reference [ fhir:value "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d" ] ] ; fhir:DiagnosticReport.performer [ fhir:index 0 ; fhir:Reference.reference [ fhir:value "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef" ] ] ; fhir:DiagnosticReport.specimen [ fhir:index 0 ; fhir:Reference.reference [ fhir:value "urn:uuid:a5d6a6a9-4859-480e-85b2-56974fef3b9d" ] ] ; fhir:DiagnosticReport.result [ fhir:index 0 ; fhir:Reference.reference [ fhir:value "urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12f" ] ; fhir:Reference.display [ fhir:value "Variants and other biomarker tests" ] ], [ fhir:index 1 ; fhir:Reference.reference [ fhir:value "urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12d" ] ; fhir:Reference.display [ fhir:value "SNV analysis for JAK2 variant" ] ], [ fhir:index 2 ; fhir:Reference.reference [ fhir:value "urn:uuid:772de7d7-e1bd-4183-bdb5-cea8eda317cd" ] ; fhir:Reference.display [ fhir:value "SNV analysis for KDR variant" ] ], [ fhir:index 3 ; fhir:Reference.reference [ fhir:value "urn:uuid:b33eb7ec-d83e-49d2-b0f3-729d024ebe01" ] ; fhir:Reference.display [ fhir:value "SNV analysis for ERBB4 variant" ] ], [ fhir:index 4 ; fhir:Reference.reference [ fhir:value "urn:uuid:40e85eda-4d31-4bd2-a5a0-c39d63f9824f" ] ; fhir:Reference.display [ fhir:value "TMB value analysis" ] ], [ fhir:index 5 ; fhir:Reference.reference [ fhir:value "urn:uuid:64b91716-6431-41bd-8fd4-7ac99bebdee9" ] ; fhir:Reference.display [ fhir:value "MSI status analysis" ] ], [ fhir:index 6 ; fhir:Reference.reference [ fhir:value "urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12e" ] ; fhir:Reference.display [ fhir:value "Therapy Match Results" ] ], [ fhir:index 7 ; fhir:Reference.reference [ fhir:value "urn:uuid:1bf9642d-fd1c-4819-8c5d-44fae4bad524" ] ; fhir:Reference.display [ fhir:value "Therapy match result 1" ] ], [ fhir:index 8 ; fhir:Reference.reference [ fhir:value "urn:uuid:1301943b-55db-4adf-8355-3635f7268a1b" ] ; fhir:Reference.display [ fhir:value "Therapy match result 2" ] ], [ fhir:index 9 ; fhir:Reference.reference [ fhir:value "urn:uuid:05713d1c-0df5-46d5-a5a9-2085eef56c20" ] ; fhir:Reference.display [ fhir:value "Therapy match result 3" ] ], [ fhir:index 10 ; fhir:Reference.reference [ fhir:value "urn:uuid:294f1401-e2eb-4df1-b6d2-09e1b7a6eca4" ] ; fhir:Reference.display [ fhir:value "Therapy match result 4" ] ] . # - ontology header ------------------------------------------------------------ <http://hl7.org/fhir/Bundle/bundle-oncologyexamples-r4-withGrouping.ttl> a owl:Ontology ; owl:imports fhir:fhir.ttl ; owl:versionIRI <http://build.fhir.org/Bundle/bundle-oncologyexamples-r4-withGrouping.ttl> .
IG © 2025+ HL7 International / Clinical Genomics. Package hl7.fhir.uv.genomics-reporting#4.0.0-cibuild based on FHIR 4.0.1. Generated 2026-09-21
Links: Table of Contents |
QA Report
| Version History |
|
Propose a change