Global Core Electronic Medicinal Product Information (ePI)
1.1.0 - trial-use World

Global Core Electronic Medicinal Product Information (ePI), published by HL7 International / Biomedical Research and Regulation. This guide is not an authorized publication; it is the continuous build for version 1.1.0 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/emedicinal-product-info/ and changes regularly. See the Directory of published versions

: MedicationKnowledge - Diflucan

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{
  "resourceType" : "MedicationKnowledge",
  "id" : "mk-diflucan",
  "meta" : {
    "profile" : [
      🔗 "http://hl7.org/fhir/uv/emedicinal-product-info/StructureDefinition/MedicationKnowledge-uv-epi"
    ]
  },
  "language" : "en",
  "text" : {
    "status" : "generated",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: MedicationKnowledge mk-diflucan</b></p><a name=\"mk-diflucan\"> </a><a name=\"hcmk-diflucan\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-MedicationKnowledge-uv-epi.html\">MedicationKnowledge (ePI)</a></p></div><p><b>identifier</b>: <code>http://example.org/identifier</code>/mk-diflucan</p><p><b>status</b>: Active</p><blockquote><p><b>indicationGuideline</b></p><h3>Indications</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"ClinicalUseDefinition-cud-diflucan-mucosal.html\">ClinicalUseDefinition: identifier = http://example.org/identifier#cud-diflucan-mucosal; type = indication; category = Indication; status = Active</a></td></tr></table><blockquote><p><b>dosingGuideline</b></p><blockquote><p><b>dosage</b></p><p><b>type</b>: <span title=\"Codes:\">Loading dose (Day 1)</span></p><blockquote><p><b>dosage</b></p><p><b>sequence</b>: 1</p><p><b>text</b>: 200 to 400 mg on Day 1</p><h3>DoseAndRates</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Dose[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>200-400 mg</td></tr></table></blockquote></blockquote><blockquote><p><b>dosage</b></p><p><b>type</b>: <span title=\"Codes:\">Maintenance</span></p><blockquote><p><b>dosage</b></p><p><b>sequence</b>: 2</p><p><b>text</b>: 100 to 200 mg once daily for 7 to 21 days</p><p><b>timing</b>: Once per 1 day</p><h3>DoseAndRates</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Dose[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>100-200 mg</td></tr></table></blockquote></blockquote><h3>PatientCharacteristics</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-group-characteristic-type age}\">Age</span></td><td>18-? years</td></tr></table></blockquote><blockquote><p><b>dosingGuideline</b></p><blockquote><p><b>dosage</b></p><p><b>type</b>: <span title=\"Codes:\">Initial dose</span></p><blockquote><p><b>dosage</b></p><p><b>sequence</b>: 1</p><p><b>text</b>: 6 mg/kg on the first day</p><h3>DoseAndRates</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Dose[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>6 mg/kg<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  codemg/kg = 'mg/kg')</span></td></tr></table></blockquote></blockquote><blockquote><p><b>dosage</b></p><p><b>type</b>: <span title=\"Codes:\">Subsequent dose</span></p><blockquote><p><b>dosage</b></p><p><b>sequence</b>: 2</p><p><b>text</b>: 3 mg/kg once daily</p><p><b>timing</b>: Once per 1 day</p><h3>DoseAndRates</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Dose[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>3 mg/kg<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  codemg/kg = 'mg/kg')</span></td></tr></table></blockquote></blockquote><h3>PatientCharacteristics</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-group-characteristic-type age}\">Age</span></td><td>28-11 days</td></tr></table></blockquote><blockquote><p><b>dosingGuideline</b></p><blockquote><p><b>dosage</b></p><p><b>type</b>: <span title=\"Codes:\">Neonatal dose</span></p><blockquote><p><b>dosage</b></p><p><b>sequence</b>: 1</p><p><b>text</b>: 3 mg/kg every 72 hours (max 12 mg/kg every 72 hours)</p><p><b>timing</b>: Once per 72 hours</p><h3>DoseAndRates</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Dose[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>3 mg/kg<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  codemg/kg = 'mg/kg')</span></td></tr></table><p><b>maxDosePerPeriod</b>: 12 mg/kg<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  codemg/kg = 'mg/kg')</span>/72 hours<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  codeh = 'h')</span></p></blockquote></blockquote><h3>PatientCharacteristics</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-group-characteristic-type age}\">Age</span></td><td>0-14 days</td></tr></table></blockquote></blockquote><blockquote><p><b>indicationGuideline</b></p><h3>Indications</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"ClinicalUseDefinition-cud-diflucan-invasive.html\">ClinicalUseDefinition: identifier = http://example.org/identifier#cud-diflucan-invasive; type = indication; category = Indication; status = Active</a></td></tr></table><blockquote><p><b>dosingGuideline</b></p><blockquote><p><b>dosage</b></p><p><b>type</b>: <span title=\"Codes:\">Loading dose (Day 1)</span></p><blockquote><p><b>dosage</b></p><p><b>sequence</b>: 1</p><p><b>text</b>: 800 mg on Day 1</p><h3>DoseAndRates</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Dose[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>800 mg<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  codemg = 'mg')</span></td></tr></table></blockquote></blockquote><blockquote><p><b>dosage</b></p><p><b>type</b>: <span title=\"Codes:\">Maintenance</span></p><blockquote><p><b>dosage</b></p><p><b>sequence</b>: 2</p><p><b>text</b>: 400 mg once daily</p><p><b>timing</b>: Once per 1 day</p><h3>DoseAndRates</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Dose[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>400 mg<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  codemg = 'mg')</span></td></tr></table></blockquote></blockquote></blockquote></blockquote></div>"
  },
  "identifier" : [
    {
      "system" : "http://example.org/identifier",
      "value" : "mk-diflucan"
    }
  ],
  "status" : "active",
  "indicationGuideline" : [
    {
      "indication" : [
        {
          "reference" : {
            🔗 "reference" : "ClinicalUseDefinition/cud-diflucan-mucosal"
          }
        }
      ],
      "dosingGuideline" : [
        {
          "dosage" : [
            {
              "type" : {
                "text" : "Loading dose (Day 1)"
              },
              "dosage" : [
                {
                  "sequence" : 1,
                  "text" : "200 to 400 mg on Day 1",
                  "doseAndRate" : [
                    {
                      "doseRange" : {
                        "low" : {
                          "value" : 200,
                          "unit" : "mg",
                          "system" : "http://unitsofmeasure.org",
                          "code" : "mg"
                        },
                        "high" : {
                          "value" : 400,
                          "unit" : "mg",
                          "system" : "http://unitsofmeasure.org",
                          "code" : "mg"
                        }
                      }
                    }
                  ]
                }
              ]
            },
            {
              "type" : {
                "text" : "Maintenance"
              },
              "dosage" : [
                {
                  "sequence" : 2,
                  "text" : "100 to 200 mg once daily for 7 to 21 days",
                  "timing" : {
                    "repeat" : {
                      "frequency" : 1,
                      "period" : 1,
                      "periodUnit" : "d"
                    }
                  },
                  "doseAndRate" : [
                    {
                      "doseRange" : {
                        "low" : {
                          "value" : 100,
                          "unit" : "mg",
                          "system" : "http://unitsofmeasure.org",
                          "code" : "mg"
                        },
                        "high" : {
                          "value" : 200,
                          "unit" : "mg",
                          "system" : "http://unitsofmeasure.org",
                          "code" : "mg"
                        }
                      }
                    }
                  ]
                }
              ]
            }
          ],
          "patientCharacteristic" : [
            {
              "type" : {
                "coding" : [
                  {
                    "system" : "http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-group-characteristic-type",
                    "code" : "age",
                    "display" : "Age"
                  }
                ]
              },
              "valueRange" : {
                "low" : {
                  "value" : 18,
                  "unit" : "years",
                  "system" : "http://unitsofmeasure.org",
                  "code" : "a"
                }
              }
            }
          ]
        },
        {
          "dosage" : [
            {
              "type" : {
                "text" : "Initial dose"
              },
              "dosage" : [
                {
                  "sequence" : 1,
                  "text" : "6 mg/kg on the first day",
                  "doseAndRate" : [
                    {
                      "doseQuantity" : {
                        "value" : 6,
                        "unit" : "mg/kg",
                        "system" : "http://unitsofmeasure.org",
                        "code" : "mg/kg"
                      }
                    }
                  ]
                }
              ]
            },
            {
              "type" : {
                "text" : "Subsequent dose"
              },
              "dosage" : [
                {
                  "sequence" : 2,
                  "text" : "3 mg/kg once daily",
                  "timing" : {
                    "repeat" : {
                      "frequency" : 1,
                      "period" : 1,
                      "periodUnit" : "d"
                    }
                  },
                  "doseAndRate" : [
                    {
                      "doseQuantity" : {
                        "value" : 3,
                        "unit" : "mg/kg",
                        "system" : "http://unitsofmeasure.org",
                        "code" : "mg/kg"
                      }
                    }
                  ]
                }
              ]
            }
          ],
          "patientCharacteristic" : [
            {
              "type" : {
                "coding" : [
                  {
                    "system" : "http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-group-characteristic-type",
                    "code" : "age",
                    "display" : "Age"
                  }
                ]
              },
              "valueRange" : {
                "low" : {
                  "value" : 28,
                  "unit" : "days",
                  "system" : "http://unitsofmeasure.org",
                  "code" : "d"
                },
                "high" : {
                  "value" : 11,
                  "unit" : "years",
                  "system" : "http://unitsofmeasure.org",
                  "code" : "a"
                }
              }
            }
          ]
        },
        {
          "dosage" : [
            {
              "type" : {
                "text" : "Neonatal dose"
              },
              "dosage" : [
                {
                  "sequence" : 1,
                  "text" : "3 mg/kg every 72 hours (max 12 mg/kg every 72 hours)",
                  "timing" : {
                    "repeat" : {
                      "frequency" : 1,
                      "period" : 72,
                      "periodUnit" : "h"
                    }
                  },
                  "doseAndRate" : [
                    {
                      "doseQuantity" : {
                        "value" : 3,
                        "unit" : "mg/kg",
                        "system" : "http://unitsofmeasure.org",
                        "code" : "mg/kg"
                      }
                    }
                  ],
                  "maxDosePerPeriod" : [
                    {
                      "numerator" : {
                        "value" : 12,
                        "unit" : "mg/kg",
                        "system" : "http://unitsofmeasure.org",
                        "code" : "mg/kg"
                      },
                      "denominator" : {
                        "value" : 72,
                        "unit" : "hours",
                        "system" : "http://unitsofmeasure.org",
                        "code" : "h"
                      }
                    }
                  ]
                }
              ]
            }
          ],
          "patientCharacteristic" : [
            {
              "type" : {
                "coding" : [
                  {
                    "system" : "http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-group-characteristic-type",
                    "code" : "age",
                    "display" : "Age"
                  }
                ]
              },
              "valueRange" : {
                "low" : {
                  "value" : 0,
                  "unit" : "days",
                  "system" : "http://unitsofmeasure.org",
                  "code" : "d"
                },
                "high" : {
                  "value" : 14,
                  "unit" : "days",
                  "system" : "http://unitsofmeasure.org",
                  "code" : "d"
                }
              }
            }
          ]
        }
      ]
    },
    {
      "indication" : [
        {
          "reference" : {
            🔗 "reference" : "ClinicalUseDefinition/cud-diflucan-invasive"
          }
        }
      ],
      "dosingGuideline" : [
        {
          "dosage" : [
            {
              "type" : {
                "text" : "Loading dose (Day 1)"
              },
              "dosage" : [
                {
                  "sequence" : 1,
                  "text" : "800 mg on Day 1",
                  "doseAndRate" : [
                    {
                      "doseQuantity" : {
                        "value" : 800,
                        "unit" : "mg",
                        "system" : "http://unitsofmeasure.org",
                        "code" : "mg"
                      }
                    }
                  ]
                }
              ]
            },
            {
              "type" : {
                "text" : "Maintenance"
              },
              "dosage" : [
                {
                  "sequence" : 2,
                  "text" : "400 mg once daily",
                  "timing" : {
                    "repeat" : {
                      "frequency" : 1,
                      "period" : 1,
                      "periodUnit" : "d"
                    }
                  },
                  "doseAndRate" : [
                    {
                      "doseQuantity" : {
                        "value" : 400,
                        "unit" : "mg",
                        "system" : "http://unitsofmeasure.org",
                        "code" : "mg"
                      }
                    }
                  ]
                }
              ]
            }
          ]
        }
      ]
    }
  ]
}