Global Core Electronic Medicinal Product Information (ePI), published by HL7 International / Biomedical Research and Regulation. This guide is not an authorized publication; it is the continuous build for version 1.1.0 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/emedicinal-product-info/ and changes regularly. See the Directory of published versions

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: MedicationKnowledge - Diflucan

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<MedicationKnowledge xmlns="http://hl7.org/fhir">
  <id value="mk-diflucan"/>
  <meta>
    <profile
             value="http://hl7.org/fhir/uv/emedicinal-product-info/StructureDefinition/MedicationKnowledge-uv-epi"/>
  </meta>
  <language value="en"/>
  <text>
    <status value="generated"/>
    <div xmlns="http://www.w3.org/1999/xhtml"><p class="res-header-id"><b>Generated Narrative: MedicationKnowledge mk-diflucan</b></p><a name="mk-diflucan"> </a><a name="hcmk-diflucan"> </a><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px"/><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-MedicationKnowledge-uv-epi.html">MedicationKnowledge (ePI)</a></p></div><p><b>identifier</b>: <code>http://example.org/identifier</code>/mk-diflucan</p><p><b>status</b>: Active</p><blockquote><p><b>indicationGuideline</b></p><h3>Indications</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td><a href="ClinicalUseDefinition-cud-diflucan-mucosal.html">ClinicalUseDefinition: identifier = http://example.org/identifier#cud-diflucan-mucosal; type = indication; category = Indication; status = Active</a></td></tr></table><blockquote><p><b>dosingGuideline</b></p><blockquote><p><b>dosage</b></p><p><b>type</b>: <span title="Codes:">Loading dose (Day 1)</span></p><blockquote><p><b>dosage</b></p><p><b>sequence</b>: 1</p><p><b>text</b>: 200 to 400 mg on Day 1</p><h3>DoseAndRates</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Dose[x]</b></td></tr><tr><td style="display: none">*</td><td>200-400 mg</td></tr></table></blockquote></blockquote><blockquote><p><b>dosage</b></p><p><b>type</b>: <span title="Codes:">Maintenance</span></p><blockquote><p><b>dosage</b></p><p><b>sequence</b>: 2</p><p><b>text</b>: 100 to 200 mg once daily for 7 to 21 days</p><p><b>timing</b>: Once per 1 day</p><h3>DoseAndRates</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Dose[x]</b></td></tr><tr><td style="display: none">*</td><td>100-200 mg</td></tr></table></blockquote></blockquote><h3>PatientCharacteristics</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-group-characteristic-type age}">Age</span></td><td>18-? years</td></tr></table></blockquote><blockquote><p><b>dosingGuideline</b></p><blockquote><p><b>dosage</b></p><p><b>type</b>: <span title="Codes:">Initial dose</span></p><blockquote><p><b>dosage</b></p><p><b>sequence</b>: 1</p><p><b>text</b>: 6 mg/kg on the first day</p><h3>DoseAndRates</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Dose[x]</b></td></tr><tr><td style="display: none">*</td><td>6 mg/kg<span style="background: LightGoldenRodYellow"> (Details: UCUM  codemg/kg = 'mg/kg')</span></td></tr></table></blockquote></blockquote><blockquote><p><b>dosage</b></p><p><b>type</b>: <span title="Codes:">Subsequent dose</span></p><blockquote><p><b>dosage</b></p><p><b>sequence</b>: 2</p><p><b>text</b>: 3 mg/kg once daily</p><p><b>timing</b>: Once per 1 day</p><h3>DoseAndRates</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Dose[x]</b></td></tr><tr><td style="display: none">*</td><td>3 mg/kg<span style="background: LightGoldenRodYellow"> (Details: UCUM  codemg/kg = 'mg/kg')</span></td></tr></table></blockquote></blockquote><h3>PatientCharacteristics</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-group-characteristic-type age}">Age</span></td><td>28-11 days</td></tr></table></blockquote><blockquote><p><b>dosingGuideline</b></p><blockquote><p><b>dosage</b></p><p><b>type</b>: <span title="Codes:">Neonatal dose</span></p><blockquote><p><b>dosage</b></p><p><b>sequence</b>: 1</p><p><b>text</b>: 3 mg/kg every 72 hours (max 12 mg/kg every 72 hours)</p><p><b>timing</b>: Once per 72 hours</p><h3>DoseAndRates</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Dose[x]</b></td></tr><tr><td style="display: none">*</td><td>3 mg/kg<span style="background: LightGoldenRodYellow"> (Details: UCUM  codemg/kg = 'mg/kg')</span></td></tr></table><p><b>maxDosePerPeriod</b>: 12 mg/kg<span style="background: LightGoldenRodYellow"> (Details: UCUM  codemg/kg = 'mg/kg')</span>/72 hours<span style="background: LightGoldenRodYellow"> (Details: UCUM  codeh = 'h')</span></p></blockquote></blockquote><h3>PatientCharacteristics</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-group-characteristic-type age}">Age</span></td><td>0-14 days</td></tr></table></blockquote></blockquote><blockquote><p><b>indicationGuideline</b></p><h3>Indications</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td><a href="ClinicalUseDefinition-cud-diflucan-invasive.html">ClinicalUseDefinition: identifier = http://example.org/identifier#cud-diflucan-invasive; type = indication; category = Indication; status = Active</a></td></tr></table><blockquote><p><b>dosingGuideline</b></p><blockquote><p><b>dosage</b></p><p><b>type</b>: <span title="Codes:">Loading dose (Day 1)</span></p><blockquote><p><b>dosage</b></p><p><b>sequence</b>: 1</p><p><b>text</b>: 800 mg on Day 1</p><h3>DoseAndRates</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Dose[x]</b></td></tr><tr><td style="display: none">*</td><td>800 mg<span style="background: LightGoldenRodYellow"> (Details: UCUM  codemg = 'mg')</span></td></tr></table></blockquote></blockquote><blockquote><p><b>dosage</b></p><p><b>type</b>: <span title="Codes:">Maintenance</span></p><blockquote><p><b>dosage</b></p><p><b>sequence</b>: 2</p><p><b>text</b>: 400 mg once daily</p><p><b>timing</b>: Once per 1 day</p><h3>DoseAndRates</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Dose[x]</b></td></tr><tr><td style="display: none">*</td><td>400 mg<span style="background: LightGoldenRodYellow"> (Details: UCUM  codemg = 'mg')</span></td></tr></table></blockquote></blockquote></blockquote></blockquote></div>
  </text>
  <identifier>
    <system value="http://example.org/identifier"/>
    <value value="mk-diflucan"/>
  </identifier>
  <status value="active"/>
  <indicationGuideline>
    <indication>
      <reference>🔗 
        <reference value="ClinicalUseDefinition/cud-diflucan-mucosal"/>
      </reference>
    </indication>
    <dosingGuideline>
      <dosage>
        <type>
          <text value="Loading dose (Day 1)"/>
        </type>
        <dosage>
          <sequence value="1"/>
          <text value="200 to 400 mg on Day 1"/>
          <doseAndRate>
            <doseRange>
              <low>
                <value value="200"/>
                <unit value="mg"/>
                <system value="http://unitsofmeasure.org"/>
                <code value="mg"/>
              </low>
              <high>
                <value value="400"/>
                <unit value="mg"/>
                <system value="http://unitsofmeasure.org"/>
                <code value="mg"/>
              </high>
            </doseRange>
          </doseAndRate>
        </dosage>
      </dosage>
      <dosage>
        <type>
          <text value="Maintenance"/>
        </type>
        <dosage>
          <sequence value="2"/>
          <text value="100 to 200 mg once daily for 7 to 21 days"/>
          <timing>
            <repeat>
              <frequency value="1"/>
              <period value="1"/>
              <periodUnit value="d"/>
            </repeat>
          </timing>
          <doseAndRate>
            <doseRange>
              <low>
                <value value="100"/>
                <unit value="mg"/>
                <system value="http://unitsofmeasure.org"/>
                <code value="mg"/>
              </low>
              <high>
                <value value="200"/>
                <unit value="mg"/>
                <system value="http://unitsofmeasure.org"/>
                <code value="mg"/>
              </high>
            </doseRange>
          </doseAndRate>
        </dosage>
      </dosage>
      <patientCharacteristic>
        <type>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-group-characteristic-type"/>
            <code value="age"/>
            <display value="Age"/>
          </coding>
        </type>
        <valueRange>
          <low>
            <value value="18"/>
            <unit value="years"/>
            <system value="http://unitsofmeasure.org"/>
            <code value="a"/>
          </low>
        </valueRange>
      </patientCharacteristic>
    </dosingGuideline>
    <dosingGuideline>
      <dosage>
        <type>
          <text value="Initial dose"/>
        </type>
        <dosage>
          <sequence value="1"/>
          <text value="6 mg/kg on the first day"/>
          <doseAndRate>
            <doseQuantity>
              <value value="6"/>
              <unit value="mg/kg"/>
              <system value="http://unitsofmeasure.org"/>
              <code value="mg/kg"/>
            </doseQuantity>
          </doseAndRate>
        </dosage>
      </dosage>
      <dosage>
        <type>
          <text value="Subsequent dose"/>
        </type>
        <dosage>
          <sequence value="2"/>
          <text value="3 mg/kg once daily"/>
          <timing>
            <repeat>
              <frequency value="1"/>
              <period value="1"/>
              <periodUnit value="d"/>
            </repeat>
          </timing>
          <doseAndRate>
            <doseQuantity>
              <value value="3"/>
              <unit value="mg/kg"/>
              <system value="http://unitsofmeasure.org"/>
              <code value="mg/kg"/>
            </doseQuantity>
          </doseAndRate>
        </dosage>
      </dosage>
      <patientCharacteristic>
        <type>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-group-characteristic-type"/>
            <code value="age"/>
            <display value="Age"/>
          </coding>
        </type>
        <valueRange>
          <low>
            <value value="28"/>
            <unit value="days"/>
            <system value="http://unitsofmeasure.org"/>
            <code value="d"/>
          </low>
          <high>
            <value value="11"/>
            <unit value="years"/>
            <system value="http://unitsofmeasure.org"/>
            <code value="a"/>
          </high>
        </valueRange>
      </patientCharacteristic>
    </dosingGuideline>
    <dosingGuideline>
      <dosage>
        <type>
          <text value="Neonatal dose"/>
        </type>
        <dosage>
          <sequence value="1"/>
          <text value="3 mg/kg every 72 hours (max 12 mg/kg every 72 hours)"/>
          <timing>
            <repeat>
              <frequency value="1"/>
              <period value="72"/>
              <periodUnit value="h"/>
            </repeat>
          </timing>
          <doseAndRate>
            <doseQuantity>
              <value value="3"/>
              <unit value="mg/kg"/>
              <system value="http://unitsofmeasure.org"/>
              <code value="mg/kg"/>
            </doseQuantity>
          </doseAndRate>
          <maxDosePerPeriod>
            <numerator>
              <value value="12"/>
              <unit value="mg/kg"/>
              <system value="http://unitsofmeasure.org"/>
              <code value="mg/kg"/>
            </numerator>
            <denominator>
              <value value="72"/>
              <unit value="hours"/>
              <system value="http://unitsofmeasure.org"/>
              <code value="h"/>
            </denominator>
          </maxDosePerPeriod>
        </dosage>
      </dosage>
      <patientCharacteristic>
        <type>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-group-characteristic-type"/>
            <code value="age"/>
            <display value="Age"/>
          </coding>
        </type>
        <valueRange>
          <low>
            <value value="0"/>
            <unit value="days"/>
            <system value="http://unitsofmeasure.org"/>
            <code value="d"/>
          </low>
          <high>
            <value value="14"/>
            <unit value="days"/>
            <system value="http://unitsofmeasure.org"/>
            <code value="d"/>
          </high>
        </valueRange>
      </patientCharacteristic>
    </dosingGuideline>
  </indicationGuideline>
  <indicationGuideline>
    <indication>
      <reference>🔗 
        <reference value="ClinicalUseDefinition/cud-diflucan-invasive"/>
      </reference>
    </indication>
    <dosingGuideline>
      <dosage>
        <type>
          <text value="Loading dose (Day 1)"/>
        </type>
        <dosage>
          <sequence value="1"/>
          <text value="800 mg on Day 1"/>
          <doseAndRate>
            <doseQuantity>
              <value value="800"/>
              <unit value="mg"/>
              <system value="http://unitsofmeasure.org"/>
              <code value="mg"/>
            </doseQuantity>
          </doseAndRate>
        </dosage>
      </dosage>
      <dosage>
        <type>
          <text value="Maintenance"/>
        </type>
        <dosage>
          <sequence value="2"/>
          <text value="400 mg once daily"/>
          <timing>
            <repeat>
              <frequency value="1"/>
              <period value="1"/>
              <periodUnit value="d"/>
            </repeat>
          </timing>
          <doseAndRate>
            <doseQuantity>
              <value value="400"/>
              <unit value="mg"/>
              <system value="http://unitsofmeasure.org"/>
              <code value="mg"/>
            </doseQuantity>
          </doseAndRate>
        </dosage>
      </dosage>
    </dosingGuideline>
  </indicationGuideline>
</MedicationKnowledge>