{ "resourceType" : "MedicationKnowledge", "id" : "mk-diflucan", "meta" : { "profile" : ["http://hl7.org/fhir/uv/emedicinal-product-info/StructureDefinition/MedicationKnowledge-uv-epi"] }, "language" : "en", "text" : { "status" : "generated", "div" : "

Generated Narrative: MedicationKnowledge mk-diflucan

Profile: MedicationKnowledge (ePI)

identifier: http://example.org/identifier/mk-diflucan

status: Active

indicationGuideline

Indications

-Reference
*ClinicalUseDefinition: identifier = http://example.org/identifier#cud-diflucan-mucosal; type = indication; category = Indication; status = Active

dosingGuideline

dosage

type: Loading dose (Day 1)

dosage

sequence: 1

text: 200 to 400 mg on Day 1

DoseAndRates

-Dose[x]
*200-400 mg

dosage

type: Maintenance

dosage

sequence: 2

text: 100 to 200 mg once daily for 7 to 21 days

timing: Once per 1 day

DoseAndRates

-Dose[x]
*100-200 mg

PatientCharacteristics

-TypeValue[x]
*Age18-? years

dosingGuideline

dosage

type: Initial dose

dosage

sequence: 1

text: 6 mg/kg on the first day

DoseAndRates

-Dose[x]
*6 mg/kg (Details: UCUM codemg/kg = 'mg/kg')

dosage

type: Subsequent dose

dosage

sequence: 2

text: 3 mg/kg once daily

timing: Once per 1 day

DoseAndRates

-Dose[x]
*3 mg/kg (Details: UCUM codemg/kg = 'mg/kg')

PatientCharacteristics

-TypeValue[x]
*Age28-11 days

dosingGuideline

dosage

type: Neonatal dose

dosage

sequence: 1

text: 3 mg/kg every 72 hours (max 12 mg/kg every 72 hours)

timing: Once per 72 hours

DoseAndRates

-Dose[x]
*3 mg/kg (Details: UCUM codemg/kg = 'mg/kg')

maxDosePerPeriod: 12 mg/kg (Details: UCUM codemg/kg = 'mg/kg')/72 hours (Details: UCUM codeh = 'h')

PatientCharacteristics

-TypeValue[x]
*Age0-14 days

indicationGuideline

Indications

-Reference
*ClinicalUseDefinition: identifier = http://example.org/identifier#cud-diflucan-invasive; type = indication; category = Indication; status = Active

dosingGuideline

dosage

type: Loading dose (Day 1)

dosage

sequence: 1

text: 800 mg on Day 1

DoseAndRates

-Dose[x]
*800 mg (Details: UCUM codemg = 'mg')

dosage

type: Maintenance

dosage

sequence: 2

text: 400 mg once daily

timing: Once per 1 day

DoseAndRates

-Dose[x]
*400 mg (Details: UCUM codemg = 'mg')
" }, "identifier" : [{ "system" : "http://example.org/identifier", "value" : "mk-diflucan" }], "status" : "active", "indicationGuideline" : [{ "indication" : [{ "reference" : { "reference" : "ClinicalUseDefinition/cud-diflucan-mucosal" } }], "dosingGuideline" : [{ "dosage" : [{ "type" : { "text" : "Loading dose (Day 1)" }, "dosage" : [{ "sequence" : 1, "text" : "200 to 400 mg on Day 1", "doseAndRate" : [{ "doseRange" : { "low" : { "value" : 200, "unit" : "mg", "system" : "http://unitsofmeasure.org", "code" : "mg" }, "high" : { "value" : 400, "unit" : "mg", "system" : "http://unitsofmeasure.org", "code" : "mg" } } }] }] }, { "type" : { "text" : "Maintenance" }, "dosage" : [{ "sequence" : 2, "text" : "100 to 200 mg once daily for 7 to 21 days", "timing" : { "repeat" : { "frequency" : 1, "period" : 1, "periodUnit" : "d" } }, "doseAndRate" : [{ "doseRange" : { "low" : { "value" : 100, "unit" : "mg", "system" : "http://unitsofmeasure.org", "code" : "mg" }, "high" : { "value" : 200, "unit" : "mg", "system" : "http://unitsofmeasure.org", "code" : "mg" } } }] }] }], "patientCharacteristic" : [{ "type" : { "coding" : [{ "system" : "http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-group-characteristic-type", "code" : "age", "display" : "Age" }] }, "valueRange" : { "low" : { "value" : 18, "unit" : "years", "system" : "http://unitsofmeasure.org", "code" : "a" } } }] }, { "dosage" : [{ "type" : { "text" : "Initial dose" }, "dosage" : [{ "sequence" : 1, "text" : "6 mg/kg on the first day", "doseAndRate" : [{ "doseQuantity" : { "value" : 6, "unit" : "mg/kg", "system" : "http://unitsofmeasure.org", "code" : "mg/kg" } }] }] }, { "type" : { "text" : "Subsequent dose" }, "dosage" : [{ "sequence" : 2, "text" : "3 mg/kg once daily", "timing" : { "repeat" : { "frequency" : 1, "period" : 1, "periodUnit" : "d" } }, "doseAndRate" : [{ "doseQuantity" : { "value" : 3, "unit" : "mg/kg", "system" : "http://unitsofmeasure.org", "code" : "mg/kg" } }] }] }], "patientCharacteristic" : [{ "type" : { "coding" : [{ "system" : "http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-group-characteristic-type", "code" : "age", "display" : "Age" }] }, "valueRange" : { "low" : { "value" : 28, "unit" : "days", "system" : "http://unitsofmeasure.org", "code" : "d" }, "high" : { "value" : 11, "unit" : "years", "system" : "http://unitsofmeasure.org", "code" : "a" } } }] }, { "dosage" : [{ "type" : { "text" : "Neonatal dose" }, "dosage" : [{ "sequence" : 1, "text" : "3 mg/kg every 72 hours (max 12 mg/kg every 72 hours)", "timing" : { "repeat" : { "frequency" : 1, "period" : 72, "periodUnit" : "h" } }, "doseAndRate" : [{ "doseQuantity" : { "value" : 3, "unit" : "mg/kg", "system" : "http://unitsofmeasure.org", "code" : "mg/kg" } }], "maxDosePerPeriod" : [{ "numerator" : { "value" : 12, "unit" : "mg/kg", "system" : "http://unitsofmeasure.org", "code" : "mg/kg" }, "denominator" : { "value" : 72, "unit" : "hours", "system" : "http://unitsofmeasure.org", "code" : "h" } }] }] }], "patientCharacteristic" : [{ "type" : { "coding" : [{ "system" : "http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-group-characteristic-type", "code" : "age", "display" : "Age" }] }, "valueRange" : { "low" : { "value" : 0, "unit" : "days", "system" : "http://unitsofmeasure.org", "code" : "d" }, "high" : { "value" : 14, "unit" : "days", "system" : "http://unitsofmeasure.org", "code" : "d" } } }] }] }, { "indication" : [{ "reference" : { "reference" : "ClinicalUseDefinition/cud-diflucan-invasive" } }], "dosingGuideline" : [{ "dosage" : [{ "type" : { "text" : "Loading dose (Day 1)" }, "dosage" : [{ "sequence" : 1, "text" : "800 mg on Day 1", "doseAndRate" : [{ "doseQuantity" : { "value" : 800, "unit" : "mg", "system" : "http://unitsofmeasure.org", "code" : "mg" } }] }] }, { "type" : { "text" : "Maintenance" }, "dosage" : [{ "sequence" : 2, "text" : "400 mg once daily", "timing" : { "repeat" : { "frequency" : 1, "period" : 1, "periodUnit" : "d" } }, "doseAndRate" : [{ "doseQuantity" : { "value" : 400, "unit" : "mg", "system" : "http://unitsofmeasure.org", "code" : "mg" } }] }] }] }] }] }