Pharmaceutical Quality - Chemistry, Manufacturing and Controls (PQ-CMC) Submissions to FDA
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Pharmaceutical Quality - Chemistry, Manufacturing and Controls (PQ-CMC) Submissions to FDA, published by HL7 International / Biomedical Research and Regulation. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/FHIR-us-pq-cmc-fda/ and changes regularly. See the Directory of published versions

Resource Profile: Substance General Information

Official URL: http://hl7.org/fhir/us/pq-cmc-fda/StructureDefinition/pqcmc-drug-substance-nomenclature-structure Version: 1.0.0-ballot
Active as of 2024-04-04 Computable Name: DrugSubstanceNomenclatureStructure
Other Identifiers: OID:2.16.840.1.113883.4.642.40.36.42.25

Substance General Information containting Drug Substance (Active Ingredient) nomenclature (2.3.S.1.1) and Substance Structure (2.3.S.1.2) profile.

Usage:

Formal Views of Profile Content

Description of Profiles, Differentials, Snapshots and how the different presentations work.

This structure is derived from SubstanceDefinition

NameFlagsCard.TypeDescription & Constraintsdoco
.. SubstanceDefinition C 0..* SubstanceDefinition The detailed description of a substance, typically at a level beyond what is used for prescribing
cmc-when-unii-required: A UNII is required in code for any of these categories: 'Chemical', 'Mixture', 'Nucleic Acids','Polymer','Protein'.
cmc-name-isbt: Name.type ISBT 128 required for blood products.
cmc-structure-required: A structure is required in code for any of these categories: 'Chemical', 'Mixture', 'Nucleic Acids','Polymer','Protein'.
cmc-substance-structure-graphic-required: A Substance Structure Graphic is required Required for Small Molecules. Equivalent to classification code equals 'Chemical'.
... meta
.... profile S 1..1 canonical(StructureDefinition) Profiles this resource claims to conform to
... identifier S 0..1 Identifier optional user designated identifier
... classification S 1..* CodeableConcept Substance Type
Binding: Substance Classification (required)
... supplier S 0..1 Reference(Supplier Organization) An entity that is the source for the substance. It may be different from the manufacturer
... molecularWeight S 0..1 BackboneElement Molecular Weight
.... amount S 1..1 Quantity Used to capture quantitative values for a variety of elements
..... unit 0..1 string Molecular Weight UOM
..... code S 1..1 code Coded form of the unit
Binding: Units Of Measure Terminology (required)
... structure S 1..1 BackboneElement Structural information
.... molecularFormula S 0..1 string Molecular Formula | Biopolymer Sequence
.... technique S 1..1 CodeableConcept Substance Characterization Technique
..... text S 1..1 string Plain text representation of the concept
.... representation S 1..* BackboneElement A depiction of the structure of the substance
..... representation S 0..1 string Drug Substance Structural Representation
..... format S 0..1 CodeableConcept Structural Representation Type
...... coding 0..* Coding Code defined by a terminology system
Binding: Chemical Structure Data File Type Terminology (required)
..... document S 0..1 Reference(Document Reference Attachment) Substance Structure Graphic
... code S 1..* BackboneElement Codes associated with the substance
.... code S 1..1 CodeableConcept The specific code
..... Slices for coding 0..* Coding Code defined by a terminology system
Slice: Unordered, Open by value:system
...... coding:unii 0..1 Coding UNII
....... system 1..1 uri Identity of the terminology system
Required Pattern: http://fdasis.nlm.nih.gov
...... coding:uniProt 0..1 Coding UniProt ID
....... system 1..1 uri Identity of the terminology system
Required Pattern: https://www.uniprot.org
... Slices for name SC 1..* BackboneElement Subtance Name
Slice: Unordered, Closed by value:type.coding
cmc-name-preferred: Name.preferred: at most one = true
.... name:All Slices Content/Rules for all slices
..... preferred S 0..1 boolean True when the name type is Substance Name
.... name:sys S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string Systematic
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
...... coding S 1..1 Coding Code defined by a terminology system
Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203357
....... display 1..1 string Representation defined by the system
Fixed Value: Systematic Name
..... preferred S 0..1 boolean If this is the preferred name for this substance
.... name:sub S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string Generic
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
...... coding S 1..1 Coding Code defined by a terminology system
Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C97054
....... display 1..1 string Representation defined by the system
Fixed Value: Generic Name
..... preferred S 0..1 boolean If this is the preferred name for this substance
.... name:brand S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string Brand
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
...... coding S 1..1 Coding Code defined by a terminology system
Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C71898
....... display 1..1 string Representation defined by the system
Fixed Value: Brand
..... preferred S 0..1 boolean If this is the preferred name for this substance
.... name:gsrs S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string GSRS Preferred Term
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
...... coding S 1..1 Coding Code defined by a terminology system
Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203355
....... display 1..1 string Representation defined by the system
Fixed Value: GSRS Preferred Term
..... preferred S 0..1 boolean If this is the preferred name for this substance
.... name:usp S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string USP-NF Established Name
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
...... coding S 1..1 Coding Code defined by a terminology system
Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203358
....... display 1..1 string Representation defined by the system
Fixed Value: USP-NF Established Name
..... preferred S 0..1 boolean If this is the preferred name for this substance
.... name:comp S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string Company ID/Code
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
...... coding 1..1 Coding Code defined by a terminology system
Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203354
....... display 1..1 string Representation defined by the system
Fixed Value: Company ID/Code
..... preferred S 0..1 boolean If this is the preferred name for this substance
.... name:cas S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string CAS Number
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
...... coding S 1..1 Coding Code defined by a terminology system
Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C54682
....... display 1..1 string Representation defined by the system
Fixed Value: CAS Number
..... preferred S 0..1 boolean If this is the preferred name for this substance
.... name:inn S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string INN
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
...... coding S 1..1 Coding Code defined by a terminology system
Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C142585
....... display 1..1 string Representation defined by the system
Fixed Value: INN
..... preferred S 0..1 boolean If this is the preferred name for this substance
.... name:usan S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string USAN
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
...... coding S 1..1 Coding Code defined by a terminology system
Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C96973
....... display 1..1 string Representation defined by the system
Fixed Value: USAN
..... preferred S 0..1 boolean If this is the preferred name for this substance
.... name:iupac S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string IUPAC Name
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
...... coding S 1..1 Coding Code defined by a terminology system
Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203356
....... display 1..1 string Representation defined by the system
Fixed Value: IUPAC Name
..... preferred S 0..1 boolean If this is the preferred name for this substance
.... name:isbt S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string ISBT-128 DIN
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
...... coding S 1..1 Coding Code defined by a terminology system
Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C95517
....... display 1..1 string Representation defined by the system
Fixed Value: ISBT-128 DIN
..... preferred S 0..1 boolean If this is the preferred name for this substance
... relationship S 0..* BackboneElement A link between this substance and another
.... Slices for substanceDefinition[x] 0..1 Reference(SubstanceDefinition), CodeableConcept A pointer to another substance, as a resource or a representational code
Slice: Unordered, Open by type:$this
..... substanceDefinition[x]:substanceDefinitionReference 0..1 Reference(Polymorphic Form) The substance definition of a polyphorm of the Drug Substance
.... type
..... text 0..1 string Polymorph
Required Pattern: Polymorph

doco Documentation for this format

Terminology Bindings (Differential)

PathConformanceValueSetURI
SubstanceDefinition.classificationrequiredSubstanceClassification
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/substance-classification
from this IG
SubstanceDefinition.molecularWeight.amount.coderequiredPqcmcUnitsMeasureTerminology
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-units-of-measure-terminology
from this IG
SubstanceDefinition.structure.representation.format.codingrequiredPqcmcChemicalStructureDataFileTypeTerminology
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-chemical-structure-datafile-type-terminology
from this IG

Constraints

IdGradePath(s)DetailsRequirements
cmc-name-isbterrorSubstanceDefinitionName.type ISBT 128 required for blood products.
: classification.where(coding.where(code = '8' and system = 'http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy').exists()).exists() implies name.type.coding.exists(code = '226' and system = 'http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy')
cmc-name-preferrederrorSubstanceDefinition.nameName.preferred: at most one = true
: select(preferred = true).count() < 2
cmc-structure-requirederrorSubstanceDefinitionA structure is required in code for any of these categories: 'Chemical', 'Mixture', 'Nucleic Acids','Polymer','Protein'.
: classification.coding.where(system = 'http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy' and code in ('C48807' | 'C45305' | 'C706' | 'C48803' |'C17021') ).exists() implies structure.exists()
cmc-substance-structure-graphic-requirederrorSubstanceDefinitionA Substance Structure Graphic is required Required for Small Molecules. Equivalent to classification code equals 'Chemical'.
: (classification.where(coding.where(code = '1' and system = 'http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy').exists()).exists()) implies structure.representation.exists()
cmc-when-unii-requirederrorSubstanceDefinitionA UNII is required in code for any of these categories: 'Chemical', 'Mixture', 'Nucleic Acids','Polymer','Protein'.
: classification.coding.where(system = 'http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy' and code in ('C48807' | 'C45305' | 'C706' | 'C48803' |'C17021') ).exists() implies code.code.text.exists()
NameFlagsCard.TypeDescription & Constraintsdoco
.. SubstanceDefinition C 0..* SubstanceDefinition The detailed description of a substance, typically at a level beyond what is used for prescribing
cmc-when-unii-required: A UNII is required in code for any of these categories: 'Chemical', 'Mixture', 'Nucleic Acids','Polymer','Protein'.
cmc-name-isbt: Name.type ISBT 128 required for blood products.
cmc-structure-required: A structure is required in code for any of these categories: 'Chemical', 'Mixture', 'Nucleic Acids','Polymer','Protein'.
cmc-substance-structure-graphic-required: A Substance Structure Graphic is required Required for Small Molecules. Equivalent to classification code equals 'Chemical'.
... meta Σ 0..1 Meta Metadata about the resource
.... profile SΣ 1..1 canonical(StructureDefinition) Profiles this resource claims to conform to
... implicitRules ?!Σ 0..1 uri A set of rules under which this content was created
... contained 0..* Resource Contained, inline Resources
... identifier SΣ 0..1 Identifier optional user designated identifier
... classification SΣ 1..* CodeableConcept Substance Type
Binding: Substance Classification (required)
... manufacturer SΣ 1..1 Reference(Manufacturing and/or Test Site Organization) The entity that creates, makes, produces or fabricates the substance
... supplier SΣ 0..1 Reference(Supplier Organization) An entity that is the source for the substance. It may be different from the manufacturer
... molecularWeight SΣ 0..1 BackboneElement Molecular Weight
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... amount SΣ 1..1 Quantity Used to capture quantitative values for a variety of elements
..... comparator ?!Σ 0..1 code < | <= | >= | > | ad - how to understand the value
Binding: QuantityComparator (required): How the Quantity should be understood and represented.

..... unit Σ 0..1 string Molecular Weight UOM
..... code SΣC 1..1 code Coded form of the unit
Binding: Units Of Measure Terminology (required)
... structure SΣ 1..1 BackboneElement Structural information
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... molecularFormula SΣ 0..1 string Molecular Formula | Biopolymer Sequence
.... technique SΣ 1..1 CodeableConcept Substance Characterization Technique
Binding: StructureTechnique (example): The method used to elucidate the structure of the drug substance.


..... text SΣ 1..1 string Plain text representation of the concept
.... representation SΣ 1..* BackboneElement A depiction of the structure of the substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... representation SΣ 0..1 string Drug Substance Structural Representation
..... format SΣ 0..1 CodeableConcept Structural Representation Type
Binding: SubstanceRepresentationFormat (example): A format of a substance representation.

...... coding Σ 0..* Coding Code defined by a terminology system
Binding: Chemical Structure Data File Type Terminology (required)
..... document SΣ 0..1 Reference(Document Reference Attachment) Substance Structure Graphic
... code SΣ 1..* BackboneElement Codes associated with the substance
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... code SΣ 1..1 CodeableConcept The specific code
..... Slices for coding Σ 0..* Coding Code defined by a terminology system
Slice: Unordered, Open by value:system
...... coding:unii Σ 0..1 Coding UNII
....... system Σ 1..1 uri Identity of the terminology system
Required Pattern: http://fdasis.nlm.nih.gov
...... coding:uniProt Σ 0..1 Coding UniProt ID
....... system Σ 1..1 uri Identity of the terminology system
Required Pattern: https://www.uniprot.org
... Slices for name SΣC 1..* BackboneElement Subtance Name
Slice: Unordered, Closed by value:type.coding
cmc-name-preferred: Name.preferred: at most one = true
.... name:All Slices Content/Rules for all slices
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name Σ 1..1 string The actual name
..... preferred SΣ 0..1 boolean True when the name type is Substance Name
.... name:sys SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string Systematic
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203357
....... display 1..1 string Representation defined by the system
Fixed Value: Systematic Name
..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
.... name:sub SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string Generic
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C97054
....... display 1..1 string Representation defined by the system
Fixed Value: Generic Name
..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
.... name:brand SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string Brand
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C71898
....... display 1..1 string Representation defined by the system
Fixed Value: Brand
..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
.... name:gsrs SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string GSRS Preferred Term
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203355
....... display 1..1 string Representation defined by the system
Fixed Value: GSRS Preferred Term
..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
.... name:usp SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string USP-NF Established Name
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203358
....... display 1..1 string Representation defined by the system
Fixed Value: USP-NF Established Name
..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
.... name:comp SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string Company ID/Code
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... coding Σ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203354
....... display 1..1 string Representation defined by the system
Fixed Value: Company ID/Code
..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
.... name:cas SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string CAS Number
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C54682
....... display 1..1 string Representation defined by the system
Fixed Value: CAS Number
..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
.... name:inn SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string INN
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C142585
....... display 1..1 string Representation defined by the system
Fixed Value: INN
..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
.... name:usan SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string USAN
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C96973
....... display 1..1 string Representation defined by the system
Fixed Value: USAN
..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
.... name:iupac SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string IUPAC Name
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203356
....... display 1..1 string Representation defined by the system
Fixed Value: IUPAC Name
..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
.... name:isbt SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string ISBT-128 DIN
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C95517
....... display 1..1 string Representation defined by the system
Fixed Value: ISBT-128 DIN
..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
... relationship SΣ 0..* BackboneElement A link between this substance and another
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... Slices for substanceDefinition[x] Σ 0..1 A pointer to another substance, as a resource or a representational code
Slice: Unordered, Open by type:$this
..... substanceDefinitionReference Reference(SubstanceDefinition)
..... substanceDefinitionCodeableConcept CodeableConcept
..... substanceDefinition[x]:substanceDefinitionReference Σ 0..1 Reference(Polymorphic Form) The substance definition of a polyphorm of the Drug Substance
.... type Σ 1..1 CodeableConcept For example "salt to parent", "active moiety"
Binding: SubstanceRelationshipType (example): The relationship between two substance types.

..... text Σ 0..1 string Polymorph
Required Pattern: Polymorph

doco Documentation for this format

Terminology Bindings

PathConformanceValueSetURI
SubstanceDefinition.classificationrequiredSubstanceClassification
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/substance-classification
from this IG
SubstanceDefinition.molecularWeight.amount.comparatorrequiredQuantityComparator
http://hl7.org/fhir/ValueSet/quantity-comparator|5.0.0
from the FHIR Standard
SubstanceDefinition.molecularWeight.amount.coderequiredPqcmcUnitsMeasureTerminology
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-units-of-measure-terminology
from this IG
SubstanceDefinition.structure.techniqueexampleStructureTechnique
http://hl7.org/fhir/ValueSet/substance-structure-technique
from the FHIR Standard
SubstanceDefinition.structure.representation.formatexampleSubstanceRepresentationFormat
http://hl7.org/fhir/ValueSet/substance-representation-format
from the FHIR Standard
SubstanceDefinition.structure.representation.format.codingrequiredPqcmcChemicalStructureDataFileTypeTerminology
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-chemical-structure-datafile-type-terminology
from this IG
SubstanceDefinition.name:sys.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:sub.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:brand.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:gsrs.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:usp.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:comp.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:cas.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:inn.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:usan.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:iupac.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:isbt.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.relationship.typeexampleSubstanceRelationshipType
http://hl7.org/fhir/ValueSet/substance-relationship-type
from the FHIR Standard

Constraints

IdGradePath(s)DetailsRequirements
cmc-name-isbterrorSubstanceDefinitionName.type ISBT 128 required for blood products.
: classification.where(coding.where(code = '8' and system = 'http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy').exists()).exists() implies name.type.coding.exists(code = '226' and system = 'http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy')
cmc-name-preferrederrorSubstanceDefinition.nameName.preferred: at most one = true
: select(preferred = true).count() < 2
cmc-structure-requirederrorSubstanceDefinitionA structure is required in code for any of these categories: 'Chemical', 'Mixture', 'Nucleic Acids','Polymer','Protein'.
: classification.coding.where(system = 'http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy' and code in ('C48807' | 'C45305' | 'C706' | 'C48803' |'C17021') ).exists() implies structure.exists()
cmc-substance-structure-graphic-requirederrorSubstanceDefinitionA Substance Structure Graphic is required Required for Small Molecules. Equivalent to classification code equals 'Chemical'.
: (classification.where(coding.where(code = '1' and system = 'http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy').exists()).exists()) implies structure.representation.exists()
cmc-when-unii-requirederrorSubstanceDefinitionA UNII is required in code for any of these categories: 'Chemical', 'Mixture', 'Nucleic Acids','Polymer','Protein'.
: classification.coding.where(system = 'http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy' and code in ('C48807' | 'C45305' | 'C706' | 'C48803' |'C17021') ).exists() implies code.code.text.exists()
dom-2errorSubstanceDefinitionIf the resource is contained in another resource, it SHALL NOT contain nested Resources
: contained.contained.empty()
dom-3errorSubstanceDefinitionIf the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource
: contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().ofType(canonical) | %resource.descendants().ofType(uri) | %resource.descendants().ofType(url))) or descendants().where(reference = '#').exists() or descendants().where(ofType(canonical) = '#').exists() or descendants().where(ofType(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4errorSubstanceDefinitionIf a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated
: contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5errorSubstanceDefinitionIf a resource is contained in another resource, it SHALL NOT have a security label
: contained.meta.security.empty()
dom-6best practiceSubstanceDefinitionA resource should have narrative for robust management
: text.`div`.exists()
ele-1error**ALL** elementsAll FHIR elements must have a @value or children
: hasValue() or (children().count() > id.count())
ext-1error**ALL** extensionsMust have either extensions or value[x], not both
: extension.exists() != value.exists()
NameFlagsCard.TypeDescription & Constraintsdoco
.. SubstanceDefinition C 0..* SubstanceDefinition The detailed description of a substance, typically at a level beyond what is used for prescribing
cmc-when-unii-required: A UNII is required in code for any of these categories: 'Chemical', 'Mixture', 'Nucleic Acids','Polymer','Protein'.
cmc-name-isbt: Name.type ISBT 128 required for blood products.
cmc-structure-required: A structure is required in code for any of these categories: 'Chemical', 'Mixture', 'Nucleic Acids','Polymer','Protein'.
cmc-substance-structure-graphic-required: A Substance Structure Graphic is required Required for Small Molecules. Equivalent to classification code equals 'Chemical'.
... id Σ 0..1 id Logical id of this artifact
... meta Σ 0..1 Meta Metadata about the resource
.... id 0..1 id Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
.... versionId Σ 0..1 id Version specific identifier
.... lastUpdated Σ 0..1 instant When the resource version last changed
.... source Σ 0..1 uri Identifies where the resource comes from
.... profile SΣ 1..1 canonical(StructureDefinition) Profiles this resource claims to conform to
.... security Σ 0..* Coding Security Labels applied to this resource
Binding: AllSecurityLabels (extensible): Security Labels from the Healthcare Privacy and Security Classification System.


.... tag Σ 0..* Coding Tags applied to this resource
Binding: CommonTags (example): Codes that represent various types of tags, commonly workflow-related; e.g. "Needs review by Dr. Jones".


... implicitRules ?!Σ 0..1 uri A set of rules under which this content was created
... language 0..1 code Language of the resource content
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set
... text 0..1 Narrative Text summary of the resource, for human interpretation
... contained 0..* Resource Contained, inline Resources
... extension 0..* Extension Additional content defined by implementations
... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored
... identifier SΣ 0..1 Identifier optional user designated identifier
... version Σ 0..1 string A business level version identifier of the substance
... status Σ 0..1 CodeableConcept Status of substance within the catalogue e.g. active, retired
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

... classification SΣ 1..* CodeableConcept Substance Type
Binding: Substance Classification (required)
... domain Σ 0..1 CodeableConcept If the substance applies to human or veterinary use
Binding: MedicinalProductDomain (example): Applicable domain for this product (e.g. human, veterinary).

... grade Σ 0..* CodeableConcept The quality standard, established benchmark, to which substance complies (e.g. USP/NF, BP)
Binding: SubstanceGrade (example): The quality standard, established benchmark, to which a substance complies


... description Σ 0..1 markdown Textual description of the substance
... informationSource Σ 0..* Reference(Citation) Supporting literature
... note Σ 0..* Annotation Textual comment about the substance's catalogue or registry record
... manufacturer SΣ 1..1 Reference(Manufacturing and/or Test Site Organization) The entity that creates, makes, produces or fabricates the substance
... supplier SΣ 0..1 Reference(Supplier Organization) An entity that is the source for the substance. It may be different from the manufacturer
... moiety Σ 0..* BackboneElement Moiety, for structural modifications
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... role Σ 0..1 CodeableConcept Role that the moiety is playing
.... identifier Σ 0..1 Identifier Identifier by which this moiety substance is known
.... name Σ 0..1 string Textual name for this moiety substance
.... stereochemistry Σ 0..1 CodeableConcept Stereochemistry type
Binding: Stereochemistry (example): The optical rotation type of a substance.

.... opticalActivity Σ 0..1 CodeableConcept Optical activity type
Binding: OpticalActivity (example): The optical rotation type of a substance.

.... molecularFormula Σ 0..1 string Molecular formula for this moiety (e.g. with the Hill system)
.... amount[x] Σ 0..1 Quantitative value for this moiety
..... amountQuantity Quantity
..... amountString string
.... measurementType Σ 0..1 CodeableConcept The measurement type of the quantitative value
Binding: SubstanceAmountType (example): The relationship between two substance types.

... characterization Σ 0..* BackboneElement General specifications for this substance
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... technique Σ 0..1 CodeableConcept The method used to find the characterization e.g. HPLC
Binding: StructureTechnique (example): The method used to elucidate the characterization of the drug substance.

.... form Σ 0..1 CodeableConcept Describes the nature of the chemical entity and explains, for instance, whether this is a base or a salt form
Binding: SubstanceForm (example)
.... description Σ 0..1 markdown The description or justification in support of the interpretation of the data file
.... file Σ 0..* Attachment The data produced by the analytical instrument or a pictorial representation of that data. Examples: a JCAMP, JDX, or ADX file, or a chromatogram or spectrum analysis
... property Σ 0..* BackboneElement General specifications for this substance
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... type Σ 1..1 CodeableConcept A code expressing the type of property
Binding: ProductCharacteristic (example): This value set includes all observable entity codes from SNOMED CT - provided as an exemplar value set.

.... value[x] Σ 0..1 A value for the property
..... valueCodeableConcept CodeableConcept
..... valueQuantity Quantity
..... valueDate date
..... valueBoolean boolean
..... valueAttachment Attachment
... referenceInformation Σ 0..1 Reference(SubstanceReferenceInformation) General information detailing this substance
... molecularWeight SΣ 0..1 BackboneElement Molecular Weight
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... method Σ 0..1 CodeableConcept The method by which the weight was determined
Binding: WeightMethod (example): The method by which the substance weight was measured.

.... type Σ 0..1 CodeableConcept Type of molecular weight e.g. exact, average, weight average
Binding: WeightType (example): The type of substance weight measurement.

.... amount SΣ 1..1 Quantity Used to capture quantitative values for a variety of elements
..... id 0..1 id Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
..... value Σ 0..1 decimal Numerical value (with implicit precision)
..... comparator ?!Σ 0..1 code < | <= | >= | > | ad - how to understand the value
Binding: QuantityComparator (required): How the Quantity should be understood and represented.

..... unit Σ 0..1 string Molecular Weight UOM
..... system ΣC 0..1 uri System that defines coded unit form
..... code SΣC 1..1 code Coded form of the unit
Binding: Units Of Measure Terminology (required)
... structure SΣ 1..1 BackboneElement Structural information
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... stereochemistry Σ 0..1 CodeableConcept Stereochemistry type
Binding: Stereochemistry (example): The optical rotation type of a substance.

.... opticalActivity Σ 0..1 CodeableConcept Optical activity type
Binding: OpticalActivity (example): The optical rotation type of a substance.

.... molecularFormula SΣ 0..1 string Molecular Formula | Biopolymer Sequence
.... molecularFormulaByMoiety Σ 0..1 string Specified per moiety according to the Hill system
.... molecularWeight Σ 0..1 See molecularWeight (SubstanceDefinition) The molecular weight or weight range
.... technique SΣ 1..1 CodeableConcept Substance Characterization Technique
Binding: StructureTechnique (example): The method used to elucidate the structure of the drug substance.


..... id 0..1 id Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
..... coding Σ 0..* Coding Code defined by a terminology system
..... text SΣ 1..1 string Plain text representation of the concept
.... sourceDocument Σ 0..* Reference(DocumentReference) Source of information for the structure
.... representation SΣ 1..* BackboneElement A depiction of the structure of the substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... type Σ 0..1 CodeableConcept The kind of structural representation (e.g. full, partial)
Binding: SubstanceRepresentationType (example): A format of a substance representation.

..... representation SΣ 0..1 string Drug Substance Structural Representation
..... format SΣ 0..1 CodeableConcept Structural Representation Type
Binding: SubstanceRepresentationFormat (example): A format of a substance representation.

...... id 0..1 id Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
...... coding Σ 0..* Coding Code defined by a terminology system
Binding: Chemical Structure Data File Type Terminology (required)
...... text Σ 0..1 string Plain text representation of the concept
..... document SΣ 0..1 Reference(Document Reference Attachment) Substance Structure Graphic
... code SΣ 1..* BackboneElement Codes associated with the substance
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... code SΣ 1..1 CodeableConcept The specific code
..... id 0..1 id Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
..... Slices for coding Σ 0..* Coding Code defined by a terminology system
Slice: Unordered, Open by value:system
...... coding:unii Σ 0..1 Coding UNII
....... id 0..1 id Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
....... system Σ 1..1 uri Identity of the terminology system
Required Pattern: http://fdasis.nlm.nih.gov
....... version Σ 0..1 string Version of the system - if relevant
....... code ΣC 0..1 code Symbol in syntax defined by the system
....... display ΣC 0..1 string Representation defined by the system
....... userSelected Σ 0..1 boolean If this coding was chosen directly by the user
...... coding:uniProt Σ 0..1 Coding UniProt ID
....... id 0..1 id Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
....... system Σ 1..1 uri Identity of the terminology system
Required Pattern: https://www.uniprot.org
....... version Σ 0..1 string Version of the system - if relevant
....... code ΣC 0..1 code Symbol in syntax defined by the system
....... display ΣC 0..1 string Representation defined by the system
....... userSelected Σ 0..1 boolean If this coding was chosen directly by the user
..... text Σ 0..1 string Plain text representation of the concept
.... status Σ 0..1 CodeableConcept Status of the code assignment, for example 'provisional', 'approved'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

.... statusDate Σ 0..1 dateTime The date at which the code status was changed
.... note Σ 0..* Annotation Any comment can be provided in this field
.... source Σ 0..* Reference(DocumentReference) Supporting literature
... Slices for name SΣC 1..* BackboneElement Subtance Name
Slice: Unordered, Closed by value:type.coding
cmc-name-preferred: Name.preferred: at most one = true
.... name:All Slices Content/Rules for all slices
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name Σ 1..1 string The actual name
..... type Σ 0..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred SΣ 0..1 boolean True when the name type is Substance Name
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:sys SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string Systematic
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... id 0..1 id Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203357
....... display 1..1 string Representation defined by the system
Fixed Value: Systematic Name
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text Σ 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:sub SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string Generic
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... id 0..1 id Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C97054
....... display 1..1 string Representation defined by the system
Fixed Value: Generic Name
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text Σ 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:brand SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string Brand
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... id 0..1 id Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C71898
....... display 1..1 string Representation defined by the system
Fixed Value: Brand
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text Σ 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:gsrs SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string GSRS Preferred Term
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... id 0..1 id Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203355
....... display 1..1 string Representation defined by the system
Fixed Value: GSRS Preferred Term
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text Σ 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:usp SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string USP-NF Established Name
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... id 0..1 id Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203358
....... display 1..1 string Representation defined by the system
Fixed Value: USP-NF Established Name
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text Σ 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:comp SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string Company ID/Code
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... id 0..1 id Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
...... coding Σ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203354
....... display 1..1 string Representation defined by the system
Fixed Value: Company ID/Code
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text Σ 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:cas SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string CAS Number
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... id 0..1 id Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C54682
....... display 1..1 string Representation defined by the system
Fixed Value: CAS Number
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text Σ 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:inn SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string INN
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... id 0..1 id Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C142585
....... display 1..1 string Representation defined by the system
Fixed Value: INN
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text Σ 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:usan SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string USAN
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... id 0..1 id Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C96973
....... display 1..1 string Representation defined by the system
Fixed Value: USAN
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text Σ 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:iupac SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string IUPAC Name
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... id 0..1 id Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203356
....... display 1..1 string Representation defined by the system
Fixed Value: IUPAC Name
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text Σ 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:isbt SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string ISBT-128 DIN
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... id 0..1 id Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C95517
....... display 1..1 string Representation defined by the system
Fixed Value: ISBT-128 DIN
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text Σ 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
... relationship SΣ 0..* BackboneElement A link between this substance and another
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... Slices for substanceDefinition[x] Σ 0..1 A pointer to another substance, as a resource or a representational code
Slice: Unordered, Open by type:$this
..... substanceDefinitionReference Reference(SubstanceDefinition)
..... substanceDefinitionCodeableConcept CodeableConcept
..... substanceDefinition[x]:substanceDefinitionReference Σ 0..1 Reference(Polymorphic Form) The substance definition of a polyphorm of the Drug Substance
.... type Σ 1..1 CodeableConcept For example "salt to parent", "active moiety"
Binding: SubstanceRelationshipType (example): The relationship between two substance types.

..... id 0..1 id Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
..... coding Σ 0..* Coding Code defined by a terminology system
..... text Σ 0..1 string Polymorph
Required Pattern: Polymorph
.... isDefining Σ 0..1 boolean For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible relationships
.... amount[x] Σ 0..1 A numeric factor for the relationship, e.g. that a substance salt has some percentage of active substance in relation to some other
..... amountQuantity Quantity
..... amountRatio Ratio
..... amountString string
.... ratioHighLimitAmount Σ 0..1 Ratio For use when the numeric has an uncertain range
.... comparator Σ 0..1 CodeableConcept An operator for the amount, for example "average", "approximately", "less than"
Binding: SubstanceAmountType (example): The relationship between two substance types.

.... source Σ 0..* Reference(DocumentReference) Supporting literature
... nucleicAcid Σ 0..1 Reference(SubstanceNucleicAcid) Data items specific to nucleic acids
... polymer Σ 0..1 Reference(SubstancePolymer) Data items specific to polymers
... protein Σ 0..1 Reference(SubstanceProtein) Data items specific to proteins
... sourceMaterial Σ 0..1 BackboneElement Material or taxonomic/anatomical source
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... type Σ 0..1 CodeableConcept Classification of the origin of the raw material. e.g. cat hair is an Animal source type
Binding: SourceMaterialType (example): A classification that provides the origin of the substance raw material.

.... genus Σ 0..1 CodeableConcept The genus of an organism e.g. the Latin epithet of the plant/animal scientific name
Binding: SourceMaterialGenus (example): The genus of an organism, typically referring to the Latin epithet of the genus element of the plant/animal scientific name.

.... species Σ 0..1 CodeableConcept The species of an organism e.g. the Latin epithet of the species of the plant/animal
Binding: SourceMaterialSpecies (example): A species of origin a substance raw material.

.... part Σ 0..1 CodeableConcept An anatomical origin of the source material within an organism
Binding: SourceMaterialPart (example): An anatomical origin of the source material within an organism.

.... countryOfOrigin Σ 0..* CodeableConcept The country or countries where the material is harvested
Binding: CountryValueSet (required): Jurisdiction codes



doco Documentation for this format

Terminology Bindings

PathConformanceValueSetURI
SubstanceDefinition.meta.securityextensibleAllSecurityLabels
http://hl7.org/fhir/ValueSet/security-labels
from the FHIR Standard
SubstanceDefinition.meta.tagexampleCommonTags
http://hl7.org/fhir/ValueSet/common-tags
from the FHIR Standard
SubstanceDefinition.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.classificationrequiredSubstanceClassification
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/substance-classification
from this IG
SubstanceDefinition.domainexampleMedicinalProductDomain
http://hl7.org/fhir/ValueSet/medicinal-product-domain
from the FHIR Standard
SubstanceDefinition.gradeexampleSubstanceGrade
http://hl7.org/fhir/ValueSet/substance-grade
from the FHIR Standard
SubstanceDefinition.moiety.stereochemistryexampleStereochemistry
http://hl7.org/fhir/ValueSet/substance-stereochemistry
from the FHIR Standard
SubstanceDefinition.moiety.opticalActivityexampleOpticalActivity
http://hl7.org/fhir/ValueSet/substance-optical-activity
from the FHIR Standard
SubstanceDefinition.moiety.measurementTypeexampleSubstanceAmountType
http://hl7.org/fhir/ValueSet/substance-amount-type
from the FHIR Standard
SubstanceDefinition.characterization.techniqueexampleStructureTechnique
http://hl7.org/fhir/ValueSet/substance-structure-technique
from the FHIR Standard
SubstanceDefinition.characterization.formexampleSubstanceForm
http://hl7.org/fhir/ValueSet/substance-form
from the FHIR Standard
SubstanceDefinition.property.typeexampleProductCharacteristic
http://hl7.org/fhir/ValueSet/product-characteristic-codes
from the FHIR Standard
SubstanceDefinition.molecularWeight.methodexampleWeightMethod
http://hl7.org/fhir/ValueSet/substance-weight-method
from the FHIR Standard
SubstanceDefinition.molecularWeight.typeexampleWeightType
http://hl7.org/fhir/ValueSet/substance-weight-type
from the FHIR Standard
SubstanceDefinition.molecularWeight.amount.comparatorrequiredQuantityComparator
http://hl7.org/fhir/ValueSet/quantity-comparator|5.0.0
from the FHIR Standard
SubstanceDefinition.molecularWeight.amount.coderequiredPqcmcUnitsMeasureTerminology
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-units-of-measure-terminology
from this IG
SubstanceDefinition.structure.stereochemistryexampleStereochemistry
http://hl7.org/fhir/ValueSet/substance-stereochemistry
from the FHIR Standard
SubstanceDefinition.structure.opticalActivityexampleOpticalActivity
http://hl7.org/fhir/ValueSet/substance-optical-activity
from the FHIR Standard
SubstanceDefinition.structure.techniqueexampleStructureTechnique
http://hl7.org/fhir/ValueSet/substance-structure-technique
from the FHIR Standard
SubstanceDefinition.structure.representation.typeexampleSubstanceRepresentationType
http://hl7.org/fhir/ValueSet/substance-representation-type
from the FHIR Standard
SubstanceDefinition.structure.representation.formatexampleSubstanceRepresentationFormat
http://hl7.org/fhir/ValueSet/substance-representation-format
from the FHIR Standard
SubstanceDefinition.structure.representation.format.codingrequiredPqcmcChemicalStructureDataFileTypeTerminology
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-chemical-structure-datafile-type-terminology
from this IG
SubstanceDefinition.code.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:sys.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:sys.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:sys.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name:sys.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name:sys.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name:sys.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name:sys.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:sub.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:sub.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:sub.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name:sub.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name:sub.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name:sub.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name:sub.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:brand.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:brand.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:brand.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name:brand.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name:brand.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name:brand.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name:brand.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:gsrs.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:gsrs.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:gsrs.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name:gsrs.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name:gsrs.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name:gsrs.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name:gsrs.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:usp.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:usp.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:usp.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name:usp.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name:usp.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name:usp.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name:usp.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:comp.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:comp.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:comp.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name:comp.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name:comp.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name:comp.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name:comp.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:cas.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:cas.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:cas.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name:cas.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name:cas.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name:cas.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name:cas.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:inn.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:inn.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:inn.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name:inn.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name:inn.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name:inn.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name:inn.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:usan.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:usan.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:usan.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name:usan.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name:usan.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name:usan.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name:usan.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:iupac.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:iupac.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:iupac.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name:iupac.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name:iupac.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name:iupac.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name:iupac.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:isbt.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:isbt.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:isbt.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name:isbt.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name:isbt.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name:isbt.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name:isbt.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.relationship.typeexampleSubstanceRelationshipType
http://hl7.org/fhir/ValueSet/substance-relationship-type
from the FHIR Standard
SubstanceDefinition.relationship.comparatorexampleSubstanceAmountType
http://hl7.org/fhir/ValueSet/substance-amount-type
from the FHIR Standard
SubstanceDefinition.sourceMaterial.typeexampleSourceMaterialType
http://hl7.org/fhir/ValueSet/substance-source-material-type
from the FHIR Standard
SubstanceDefinition.sourceMaterial.genusexampleSourceMaterialGenus
http://hl7.org/fhir/ValueSet/substance-source-material-genus
from the FHIR Standard
SubstanceDefinition.sourceMaterial.speciesexampleSourceMaterialSpecies
http://hl7.org/fhir/ValueSet/substance-source-material-species
from the FHIR Standard
SubstanceDefinition.sourceMaterial.partexampleSourceMaterialPart
http://hl7.org/fhir/ValueSet/substance-source-material-part
from the FHIR Standard
SubstanceDefinition.sourceMaterial.countryOfOriginrequiredCountryValueSet
http://hl7.org/fhir/ValueSet/country|5.0.0
from the FHIR Standard

Constraints

IdGradePath(s)DetailsRequirements
cmc-name-isbterrorSubstanceDefinitionName.type ISBT 128 required for blood products.
: classification.where(coding.where(code = '8' and system = 'http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy').exists()).exists() implies name.type.coding.exists(code = '226' and system = 'http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy')
cmc-name-preferrederrorSubstanceDefinition.nameName.preferred: at most one = true
: select(preferred = true).count() < 2
cmc-structure-requirederrorSubstanceDefinitionA structure is required in code for any of these categories: 'Chemical', 'Mixture', 'Nucleic Acids','Polymer','Protein'.
: classification.coding.where(system = 'http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy' and code in ('C48807' | 'C45305' | 'C706' | 'C48803' |'C17021') ).exists() implies structure.exists()
cmc-substance-structure-graphic-requirederrorSubstanceDefinitionA Substance Structure Graphic is required Required for Small Molecules. Equivalent to classification code equals 'Chemical'.
: (classification.where(coding.where(code = '1' and system = 'http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy').exists()).exists()) implies structure.representation.exists()
cmc-when-unii-requirederrorSubstanceDefinitionA UNII is required in code for any of these categories: 'Chemical', 'Mixture', 'Nucleic Acids','Polymer','Protein'.
: classification.coding.where(system = 'http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy' and code in ('C48807' | 'C45305' | 'C706' | 'C48803' |'C17021') ).exists() implies code.code.text.exists()
dom-2errorSubstanceDefinitionIf the resource is contained in another resource, it SHALL NOT contain nested Resources
: contained.contained.empty()
dom-3errorSubstanceDefinitionIf the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource
: contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().ofType(canonical) | %resource.descendants().ofType(uri) | %resource.descendants().ofType(url))) or descendants().where(reference = '#').exists() or descendants().where(ofType(canonical) = '#').exists() or descendants().where(ofType(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4errorSubstanceDefinitionIf a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated
: contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5errorSubstanceDefinitionIf a resource is contained in another resource, it SHALL NOT have a security label
: contained.meta.security.empty()
dom-6best practiceSubstanceDefinitionA resource should have narrative for robust management
: text.`div`.exists()
ele-1error**ALL** elementsAll FHIR elements must have a @value or children
: hasValue() or (children().count() > id.count())
ext-1error**ALL** extensionsMust have either extensions or value[x], not both
: extension.exists() != value.exists()

This structure is derived from SubstanceDefinition

Summary

Mandatory: 9 elements(26 nested mandatory elements)
Must-Support: 75 elements

Structures

This structure refers to these other structures:

Slices

This structure defines the following Slices:

  • The element 1 is sliced based on the value of SubstanceDefinition.code.code.coding
  • The element 1 is sliced based on the value of SubstanceDefinition.name (Closed)
  • The element 1 is sliced based on the value of SubstanceDefinition.relationship.substanceDefinition[x]

Differential View

This structure is derived from SubstanceDefinition

NameFlagsCard.TypeDescription & Constraintsdoco
.. SubstanceDefinition C 0..* SubstanceDefinition The detailed description of a substance, typically at a level beyond what is used for prescribing
cmc-when-unii-required: A UNII is required in code for any of these categories: 'Chemical', 'Mixture', 'Nucleic Acids','Polymer','Protein'.
cmc-name-isbt: Name.type ISBT 128 required for blood products.
cmc-structure-required: A structure is required in code for any of these categories: 'Chemical', 'Mixture', 'Nucleic Acids','Polymer','Protein'.
cmc-substance-structure-graphic-required: A Substance Structure Graphic is required Required for Small Molecules. Equivalent to classification code equals 'Chemical'.
... meta
.... profile S 1..1 canonical(StructureDefinition) Profiles this resource claims to conform to
... identifier S 0..1 Identifier optional user designated identifier
... classification S 1..* CodeableConcept Substance Type
Binding: Substance Classification (required)
... supplier S 0..1 Reference(Supplier Organization) An entity that is the source for the substance. It may be different from the manufacturer
... molecularWeight S 0..1 BackboneElement Molecular Weight
.... amount S 1..1 Quantity Used to capture quantitative values for a variety of elements
..... unit 0..1 string Molecular Weight UOM
..... code S 1..1 code Coded form of the unit
Binding: Units Of Measure Terminology (required)
... structure S 1..1 BackboneElement Structural information
.... molecularFormula S 0..1 string Molecular Formula | Biopolymer Sequence
.... technique S 1..1 CodeableConcept Substance Characterization Technique
..... text S 1..1 string Plain text representation of the concept
.... representation S 1..* BackboneElement A depiction of the structure of the substance
..... representation S 0..1 string Drug Substance Structural Representation
..... format S 0..1 CodeableConcept Structural Representation Type
...... coding 0..* Coding Code defined by a terminology system
Binding: Chemical Structure Data File Type Terminology (required)
..... document S 0..1 Reference(Document Reference Attachment) Substance Structure Graphic
... code S 1..* BackboneElement Codes associated with the substance
.... code S 1..1 CodeableConcept The specific code
..... Slices for coding 0..* Coding Code defined by a terminology system
Slice: Unordered, Open by value:system
...... coding:unii 0..1 Coding UNII
....... system 1..1 uri Identity of the terminology system
Required Pattern: http://fdasis.nlm.nih.gov
...... coding:uniProt 0..1 Coding UniProt ID
....... system 1..1 uri Identity of the terminology system
Required Pattern: https://www.uniprot.org
... Slices for name SC 1..* BackboneElement Subtance Name
Slice: Unordered, Closed by value:type.coding
cmc-name-preferred: Name.preferred: at most one = true
.... name:All Slices Content/Rules for all slices
..... preferred S 0..1 boolean True when the name type is Substance Name
.... name:sys S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string Systematic
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
...... coding S 1..1 Coding Code defined by a terminology system
Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203357
....... display 1..1 string Representation defined by the system
Fixed Value: Systematic Name
..... preferred S 0..1 boolean If this is the preferred name for this substance
.... name:sub S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string Generic
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
...... coding S 1..1 Coding Code defined by a terminology system
Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C97054
....... display 1..1 string Representation defined by the system
Fixed Value: Generic Name
..... preferred S 0..1 boolean If this is the preferred name for this substance
.... name:brand S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string Brand
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
...... coding S 1..1 Coding Code defined by a terminology system
Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C71898
....... display 1..1 string Representation defined by the system
Fixed Value: Brand
..... preferred S 0..1 boolean If this is the preferred name for this substance
.... name:gsrs S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string GSRS Preferred Term
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
...... coding S 1..1 Coding Code defined by a terminology system
Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203355
....... display 1..1 string Representation defined by the system
Fixed Value: GSRS Preferred Term
..... preferred S 0..1 boolean If this is the preferred name for this substance
.... name:usp S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string USP-NF Established Name
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
...... coding S 1..1 Coding Code defined by a terminology system
Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203358
....... display 1..1 string Representation defined by the system
Fixed Value: USP-NF Established Name
..... preferred S 0..1 boolean If this is the preferred name for this substance
.... name:comp S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string Company ID/Code
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
...... coding 1..1 Coding Code defined by a terminology system
Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203354
....... display 1..1 string Representation defined by the system
Fixed Value: Company ID/Code
..... preferred S 0..1 boolean If this is the preferred name for this substance
.... name:cas S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string CAS Number
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
...... coding S 1..1 Coding Code defined by a terminology system
Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C54682
....... display 1..1 string Representation defined by the system
Fixed Value: CAS Number
..... preferred S 0..1 boolean If this is the preferred name for this substance
.... name:inn S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string INN
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
...... coding S 1..1 Coding Code defined by a terminology system
Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C142585
....... display 1..1 string Representation defined by the system
Fixed Value: INN
..... preferred S 0..1 boolean If this is the preferred name for this substance
.... name:usan S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string USAN
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
...... coding S 1..1 Coding Code defined by a terminology system
Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C96973
....... display 1..1 string Representation defined by the system
Fixed Value: USAN
..... preferred S 0..1 boolean If this is the preferred name for this substance
.... name:iupac S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string IUPAC Name
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
...... coding S 1..1 Coding Code defined by a terminology system
Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203356
....... display 1..1 string Representation defined by the system
Fixed Value: IUPAC Name
..... preferred S 0..1 boolean If this is the preferred name for this substance
.... name:isbt S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string ISBT-128 DIN
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
...... coding S 1..1 Coding Code defined by a terminology system
Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C95517
....... display 1..1 string Representation defined by the system
Fixed Value: ISBT-128 DIN
..... preferred S 0..1 boolean If this is the preferred name for this substance
... relationship S 0..* BackboneElement A link between this substance and another
.... Slices for substanceDefinition[x] 0..1 Reference(SubstanceDefinition), CodeableConcept A pointer to another substance, as a resource or a representational code
Slice: Unordered, Open by type:$this
..... substanceDefinition[x]:substanceDefinitionReference 0..1 Reference(Polymorphic Form) The substance definition of a polyphorm of the Drug Substance
.... type
..... text 0..1 string Polymorph
Required Pattern: Polymorph

doco Documentation for this format

Terminology Bindings (Differential)

PathConformanceValueSetURI
SubstanceDefinition.classificationrequiredSubstanceClassification
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/substance-classification
from this IG
SubstanceDefinition.molecularWeight.amount.coderequiredPqcmcUnitsMeasureTerminology
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-units-of-measure-terminology
from this IG
SubstanceDefinition.structure.representation.format.codingrequiredPqcmcChemicalStructureDataFileTypeTerminology
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-chemical-structure-datafile-type-terminology
from this IG

Constraints

IdGradePath(s)DetailsRequirements
cmc-name-isbterrorSubstanceDefinitionName.type ISBT 128 required for blood products.
: classification.where(coding.where(code = '8' and system = 'http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy').exists()).exists() implies name.type.coding.exists(code = '226' and system = 'http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy')
cmc-name-preferrederrorSubstanceDefinition.nameName.preferred: at most one = true
: select(preferred = true).count() < 2
cmc-structure-requirederrorSubstanceDefinitionA structure is required in code for any of these categories: 'Chemical', 'Mixture', 'Nucleic Acids','Polymer','Protein'.
: classification.coding.where(system = 'http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy' and code in ('C48807' | 'C45305' | 'C706' | 'C48803' |'C17021') ).exists() implies structure.exists()
cmc-substance-structure-graphic-requirederrorSubstanceDefinitionA Substance Structure Graphic is required Required for Small Molecules. Equivalent to classification code equals 'Chemical'.
: (classification.where(coding.where(code = '1' and system = 'http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy').exists()).exists()) implies structure.representation.exists()
cmc-when-unii-requirederrorSubstanceDefinitionA UNII is required in code for any of these categories: 'Chemical', 'Mixture', 'Nucleic Acids','Polymer','Protein'.
: classification.coding.where(system = 'http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy' and code in ('C48807' | 'C45305' | 'C706' | 'C48803' |'C17021') ).exists() implies code.code.text.exists()

Key Elements View

NameFlagsCard.TypeDescription & Constraintsdoco
.. SubstanceDefinition C 0..* SubstanceDefinition The detailed description of a substance, typically at a level beyond what is used for prescribing
cmc-when-unii-required: A UNII is required in code for any of these categories: 'Chemical', 'Mixture', 'Nucleic Acids','Polymer','Protein'.
cmc-name-isbt: Name.type ISBT 128 required for blood products.
cmc-structure-required: A structure is required in code for any of these categories: 'Chemical', 'Mixture', 'Nucleic Acids','Polymer','Protein'.
cmc-substance-structure-graphic-required: A Substance Structure Graphic is required Required for Small Molecules. Equivalent to classification code equals 'Chemical'.
... meta Σ 0..1 Meta Metadata about the resource
.... profile SΣ 1..1 canonical(StructureDefinition) Profiles this resource claims to conform to
... implicitRules ?!Σ 0..1 uri A set of rules under which this content was created
... contained 0..* Resource Contained, inline Resources
... identifier SΣ 0..1 Identifier optional user designated identifier
... classification SΣ 1..* CodeableConcept Substance Type
Binding: Substance Classification (required)
... manufacturer SΣ 1..1 Reference(Manufacturing and/or Test Site Organization) The entity that creates, makes, produces or fabricates the substance
... supplier SΣ 0..1 Reference(Supplier Organization) An entity that is the source for the substance. It may be different from the manufacturer
... molecularWeight SΣ 0..1 BackboneElement Molecular Weight
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... amount SΣ 1..1 Quantity Used to capture quantitative values for a variety of elements
..... comparator ?!Σ 0..1 code < | <= | >= | > | ad - how to understand the value
Binding: QuantityComparator (required): How the Quantity should be understood and represented.

..... unit Σ 0..1 string Molecular Weight UOM
..... code SΣC 1..1 code Coded form of the unit
Binding: Units Of Measure Terminology (required)
... structure SΣ 1..1 BackboneElement Structural information
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... molecularFormula SΣ 0..1 string Molecular Formula | Biopolymer Sequence
.... technique SΣ 1..1 CodeableConcept Substance Characterization Technique
Binding: StructureTechnique (example): The method used to elucidate the structure of the drug substance.


..... text SΣ 1..1 string Plain text representation of the concept
.... representation SΣ 1..* BackboneElement A depiction of the structure of the substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... representation SΣ 0..1 string Drug Substance Structural Representation
..... format SΣ 0..1 CodeableConcept Structural Representation Type
Binding: SubstanceRepresentationFormat (example): A format of a substance representation.

...... coding Σ 0..* Coding Code defined by a terminology system
Binding: Chemical Structure Data File Type Terminology (required)
..... document SΣ 0..1 Reference(Document Reference Attachment) Substance Structure Graphic
... code SΣ 1..* BackboneElement Codes associated with the substance
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... code SΣ 1..1 CodeableConcept The specific code
..... Slices for coding Σ 0..* Coding Code defined by a terminology system
Slice: Unordered, Open by value:system
...... coding:unii Σ 0..1 Coding UNII
....... system Σ 1..1 uri Identity of the terminology system
Required Pattern: http://fdasis.nlm.nih.gov
...... coding:uniProt Σ 0..1 Coding UniProt ID
....... system Σ 1..1 uri Identity of the terminology system
Required Pattern: https://www.uniprot.org
... Slices for name SΣC 1..* BackboneElement Subtance Name
Slice: Unordered, Closed by value:type.coding
cmc-name-preferred: Name.preferred: at most one = true
.... name:All Slices Content/Rules for all slices
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name Σ 1..1 string The actual name
..... preferred SΣ 0..1 boolean True when the name type is Substance Name
.... name:sys SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string Systematic
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203357
....... display 1..1 string Representation defined by the system
Fixed Value: Systematic Name
..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
.... name:sub SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string Generic
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C97054
....... display 1..1 string Representation defined by the system
Fixed Value: Generic Name
..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
.... name:brand SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string Brand
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C71898
....... display 1..1 string Representation defined by the system
Fixed Value: Brand
..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
.... name:gsrs SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string GSRS Preferred Term
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203355
....... display 1..1 string Representation defined by the system
Fixed Value: GSRS Preferred Term
..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
.... name:usp SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string USP-NF Established Name
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203358
....... display 1..1 string Representation defined by the system
Fixed Value: USP-NF Established Name
..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
.... name:comp SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string Company ID/Code
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... coding Σ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203354
....... display 1..1 string Representation defined by the system
Fixed Value: Company ID/Code
..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
.... name:cas SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string CAS Number
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C54682
....... display 1..1 string Representation defined by the system
Fixed Value: CAS Number
..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
.... name:inn SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string INN
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C142585
....... display 1..1 string Representation defined by the system
Fixed Value: INN
..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
.... name:usan SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string USAN
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C96973
....... display 1..1 string Representation defined by the system
Fixed Value: USAN
..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
.... name:iupac SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string IUPAC Name
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203356
....... display 1..1 string Representation defined by the system
Fixed Value: IUPAC Name
..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
.... name:isbt SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string ISBT-128 DIN
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C95517
....... display 1..1 string Representation defined by the system
Fixed Value: ISBT-128 DIN
..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
... relationship SΣ 0..* BackboneElement A link between this substance and another
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... Slices for substanceDefinition[x] Σ 0..1 A pointer to another substance, as a resource or a representational code
Slice: Unordered, Open by type:$this
..... substanceDefinitionReference Reference(SubstanceDefinition)
..... substanceDefinitionCodeableConcept CodeableConcept
..... substanceDefinition[x]:substanceDefinitionReference Σ 0..1 Reference(Polymorphic Form) The substance definition of a polyphorm of the Drug Substance
.... type Σ 1..1 CodeableConcept For example "salt to parent", "active moiety"
Binding: SubstanceRelationshipType (example): The relationship between two substance types.

..... text Σ 0..1 string Polymorph
Required Pattern: Polymorph

doco Documentation for this format

Terminology Bindings

PathConformanceValueSetURI
SubstanceDefinition.classificationrequiredSubstanceClassification
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/substance-classification
from this IG
SubstanceDefinition.molecularWeight.amount.comparatorrequiredQuantityComparator
http://hl7.org/fhir/ValueSet/quantity-comparator|5.0.0
from the FHIR Standard
SubstanceDefinition.molecularWeight.amount.coderequiredPqcmcUnitsMeasureTerminology
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-units-of-measure-terminology
from this IG
SubstanceDefinition.structure.techniqueexampleStructureTechnique
http://hl7.org/fhir/ValueSet/substance-structure-technique
from the FHIR Standard
SubstanceDefinition.structure.representation.formatexampleSubstanceRepresentationFormat
http://hl7.org/fhir/ValueSet/substance-representation-format
from the FHIR Standard
SubstanceDefinition.structure.representation.format.codingrequiredPqcmcChemicalStructureDataFileTypeTerminology
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-chemical-structure-datafile-type-terminology
from this IG
SubstanceDefinition.name:sys.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:sub.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:brand.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:gsrs.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:usp.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:comp.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:cas.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:inn.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:usan.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:iupac.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:isbt.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.relationship.typeexampleSubstanceRelationshipType
http://hl7.org/fhir/ValueSet/substance-relationship-type
from the FHIR Standard

Constraints

IdGradePath(s)DetailsRequirements
cmc-name-isbterrorSubstanceDefinitionName.type ISBT 128 required for blood products.
: classification.where(coding.where(code = '8' and system = 'http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy').exists()).exists() implies name.type.coding.exists(code = '226' and system = 'http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy')
cmc-name-preferrederrorSubstanceDefinition.nameName.preferred: at most one = true
: select(preferred = true).count() < 2
cmc-structure-requirederrorSubstanceDefinitionA structure is required in code for any of these categories: 'Chemical', 'Mixture', 'Nucleic Acids','Polymer','Protein'.
: classification.coding.where(system = 'http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy' and code in ('C48807' | 'C45305' | 'C706' | 'C48803' |'C17021') ).exists() implies structure.exists()
cmc-substance-structure-graphic-requirederrorSubstanceDefinitionA Substance Structure Graphic is required Required for Small Molecules. Equivalent to classification code equals 'Chemical'.
: (classification.where(coding.where(code = '1' and system = 'http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy').exists()).exists()) implies structure.representation.exists()
cmc-when-unii-requirederrorSubstanceDefinitionA UNII is required in code for any of these categories: 'Chemical', 'Mixture', 'Nucleic Acids','Polymer','Protein'.
: classification.coding.where(system = 'http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy' and code in ('C48807' | 'C45305' | 'C706' | 'C48803' |'C17021') ).exists() implies code.code.text.exists()
dom-2errorSubstanceDefinitionIf the resource is contained in another resource, it SHALL NOT contain nested Resources
: contained.contained.empty()
dom-3errorSubstanceDefinitionIf the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource
: contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().ofType(canonical) | %resource.descendants().ofType(uri) | %resource.descendants().ofType(url))) or descendants().where(reference = '#').exists() or descendants().where(ofType(canonical) = '#').exists() or descendants().where(ofType(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4errorSubstanceDefinitionIf a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated
: contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5errorSubstanceDefinitionIf a resource is contained in another resource, it SHALL NOT have a security label
: contained.meta.security.empty()
dom-6best practiceSubstanceDefinitionA resource should have narrative for robust management
: text.`div`.exists()
ele-1error**ALL** elementsAll FHIR elements must have a @value or children
: hasValue() or (children().count() > id.count())
ext-1error**ALL** extensionsMust have either extensions or value[x], not both
: extension.exists() != value.exists()

Snapshot View

NameFlagsCard.TypeDescription & Constraintsdoco
.. SubstanceDefinition C 0..* SubstanceDefinition The detailed description of a substance, typically at a level beyond what is used for prescribing
cmc-when-unii-required: A UNII is required in code for any of these categories: 'Chemical', 'Mixture', 'Nucleic Acids','Polymer','Protein'.
cmc-name-isbt: Name.type ISBT 128 required for blood products.
cmc-structure-required: A structure is required in code for any of these categories: 'Chemical', 'Mixture', 'Nucleic Acids','Polymer','Protein'.
cmc-substance-structure-graphic-required: A Substance Structure Graphic is required Required for Small Molecules. Equivalent to classification code equals 'Chemical'.
... id Σ 0..1 id Logical id of this artifact
... meta Σ 0..1 Meta Metadata about the resource
.... id 0..1 id Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
.... versionId Σ 0..1 id Version specific identifier
.... lastUpdated Σ 0..1 instant When the resource version last changed
.... source Σ 0..1 uri Identifies where the resource comes from
.... profile SΣ 1..1 canonical(StructureDefinition) Profiles this resource claims to conform to
.... security Σ 0..* Coding Security Labels applied to this resource
Binding: AllSecurityLabels (extensible): Security Labels from the Healthcare Privacy and Security Classification System.


.... tag Σ 0..* Coding Tags applied to this resource
Binding: CommonTags (example): Codes that represent various types of tags, commonly workflow-related; e.g. "Needs review by Dr. Jones".


... implicitRules ?!Σ 0..1 uri A set of rules under which this content was created
... language 0..1 code Language of the resource content
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set
... text 0..1 Narrative Text summary of the resource, for human interpretation
... contained 0..* Resource Contained, inline Resources
... extension 0..* Extension Additional content defined by implementations
... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored
... identifier SΣ 0..1 Identifier optional user designated identifier
... version Σ 0..1 string A business level version identifier of the substance
... status Σ 0..1 CodeableConcept Status of substance within the catalogue e.g. active, retired
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

... classification SΣ 1..* CodeableConcept Substance Type
Binding: Substance Classification (required)
... domain Σ 0..1 CodeableConcept If the substance applies to human or veterinary use
Binding: MedicinalProductDomain (example): Applicable domain for this product (e.g. human, veterinary).

... grade Σ 0..* CodeableConcept The quality standard, established benchmark, to which substance complies (e.g. USP/NF, BP)
Binding: SubstanceGrade (example): The quality standard, established benchmark, to which a substance complies


... description Σ 0..1 markdown Textual description of the substance
... informationSource Σ 0..* Reference(Citation) Supporting literature
... note Σ 0..* Annotation Textual comment about the substance's catalogue or registry record
... manufacturer SΣ 1..1 Reference(Manufacturing and/or Test Site Organization) The entity that creates, makes, produces or fabricates the substance
... supplier SΣ 0..1 Reference(Supplier Organization) An entity that is the source for the substance. It may be different from the manufacturer
... moiety Σ 0..* BackboneElement Moiety, for structural modifications
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... role Σ 0..1 CodeableConcept Role that the moiety is playing
.... identifier Σ 0..1 Identifier Identifier by which this moiety substance is known
.... name Σ 0..1 string Textual name for this moiety substance
.... stereochemistry Σ 0..1 CodeableConcept Stereochemistry type
Binding: Stereochemistry (example): The optical rotation type of a substance.

.... opticalActivity Σ 0..1 CodeableConcept Optical activity type
Binding: OpticalActivity (example): The optical rotation type of a substance.

.... molecularFormula Σ 0..1 string Molecular formula for this moiety (e.g. with the Hill system)
.... amount[x] Σ 0..1 Quantitative value for this moiety
..... amountQuantity Quantity
..... amountString string
.... measurementType Σ 0..1 CodeableConcept The measurement type of the quantitative value
Binding: SubstanceAmountType (example): The relationship between two substance types.

... characterization Σ 0..* BackboneElement General specifications for this substance
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... technique Σ 0..1 CodeableConcept The method used to find the characterization e.g. HPLC
Binding: StructureTechnique (example): The method used to elucidate the characterization of the drug substance.

.... form Σ 0..1 CodeableConcept Describes the nature of the chemical entity and explains, for instance, whether this is a base or a salt form
Binding: SubstanceForm (example)
.... description Σ 0..1 markdown The description or justification in support of the interpretation of the data file
.... file Σ 0..* Attachment The data produced by the analytical instrument or a pictorial representation of that data. Examples: a JCAMP, JDX, or ADX file, or a chromatogram or spectrum analysis
... property Σ 0..* BackboneElement General specifications for this substance
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... type Σ 1..1 CodeableConcept A code expressing the type of property
Binding: ProductCharacteristic (example): This value set includes all observable entity codes from SNOMED CT - provided as an exemplar value set.

.... value[x] Σ 0..1 A value for the property
..... valueCodeableConcept CodeableConcept
..... valueQuantity Quantity
..... valueDate date
..... valueBoolean boolean
..... valueAttachment Attachment
... referenceInformation Σ 0..1 Reference(SubstanceReferenceInformation) General information detailing this substance
... molecularWeight SΣ 0..1 BackboneElement Molecular Weight
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... method Σ 0..1 CodeableConcept The method by which the weight was determined
Binding: WeightMethod (example): The method by which the substance weight was measured.

.... type Σ 0..1 CodeableConcept Type of molecular weight e.g. exact, average, weight average
Binding: WeightType (example): The type of substance weight measurement.

.... amount SΣ 1..1 Quantity Used to capture quantitative values for a variety of elements
..... id 0..1 id Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
..... value Σ 0..1 decimal Numerical value (with implicit precision)
..... comparator ?!Σ 0..1 code < | <= | >= | > | ad - how to understand the value
Binding: QuantityComparator (required): How the Quantity should be understood and represented.

..... unit Σ 0..1 string Molecular Weight UOM
..... system ΣC 0..1 uri System that defines coded unit form
..... code SΣC 1..1 code Coded form of the unit
Binding: Units Of Measure Terminology (required)
... structure SΣ 1..1 BackboneElement Structural information
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... stereochemistry Σ 0..1 CodeableConcept Stereochemistry type
Binding: Stereochemistry (example): The optical rotation type of a substance.

.... opticalActivity Σ 0..1 CodeableConcept Optical activity type
Binding: OpticalActivity (example): The optical rotation type of a substance.

.... molecularFormula SΣ 0..1 string Molecular Formula | Biopolymer Sequence
.... molecularFormulaByMoiety Σ 0..1 string Specified per moiety according to the Hill system
.... molecularWeight Σ 0..1 See molecularWeight (SubstanceDefinition) The molecular weight or weight range
.... technique SΣ 1..1 CodeableConcept Substance Characterization Technique
Binding: StructureTechnique (example): The method used to elucidate the structure of the drug substance.


..... id 0..1 id Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
..... coding Σ 0..* Coding Code defined by a terminology system
..... text SΣ 1..1 string Plain text representation of the concept
.... sourceDocument Σ 0..* Reference(DocumentReference) Source of information for the structure
.... representation SΣ 1..* BackboneElement A depiction of the structure of the substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... type Σ 0..1 CodeableConcept The kind of structural representation (e.g. full, partial)
Binding: SubstanceRepresentationType (example): A format of a substance representation.

..... representation SΣ 0..1 string Drug Substance Structural Representation
..... format SΣ 0..1 CodeableConcept Structural Representation Type
Binding: SubstanceRepresentationFormat (example): A format of a substance representation.

...... id 0..1 id Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
...... coding Σ 0..* Coding Code defined by a terminology system
Binding: Chemical Structure Data File Type Terminology (required)
...... text Σ 0..1 string Plain text representation of the concept
..... document SΣ 0..1 Reference(Document Reference Attachment) Substance Structure Graphic
... code SΣ 1..* BackboneElement Codes associated with the substance
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... code SΣ 1..1 CodeableConcept The specific code
..... id 0..1 id Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
..... Slices for coding Σ 0..* Coding Code defined by a terminology system
Slice: Unordered, Open by value:system
...... coding:unii Σ 0..1 Coding UNII
....... id 0..1 id Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
....... system Σ 1..1 uri Identity of the terminology system
Required Pattern: http://fdasis.nlm.nih.gov
....... version Σ 0..1 string Version of the system - if relevant
....... code ΣC 0..1 code Symbol in syntax defined by the system
....... display ΣC 0..1 string Representation defined by the system
....... userSelected Σ 0..1 boolean If this coding was chosen directly by the user
...... coding:uniProt Σ 0..1 Coding UniProt ID
....... id 0..1 id Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
....... system Σ 1..1 uri Identity of the terminology system
Required Pattern: https://www.uniprot.org
....... version Σ 0..1 string Version of the system - if relevant
....... code ΣC 0..1 code Symbol in syntax defined by the system
....... display ΣC 0..1 string Representation defined by the system
....... userSelected Σ 0..1 boolean If this coding was chosen directly by the user
..... text Σ 0..1 string Plain text representation of the concept
.... status Σ 0..1 CodeableConcept Status of the code assignment, for example 'provisional', 'approved'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

.... statusDate Σ 0..1 dateTime The date at which the code status was changed
.... note Σ 0..* Annotation Any comment can be provided in this field
.... source Σ 0..* Reference(DocumentReference) Supporting literature
... Slices for name SΣC 1..* BackboneElement Subtance Name
Slice: Unordered, Closed by value:type.coding
cmc-name-preferred: Name.preferred: at most one = true
.... name:All Slices Content/Rules for all slices
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name Σ 1..1 string The actual name
..... type Σ 0..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred SΣ 0..1 boolean True when the name type is Substance Name
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:sys SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string Systematic
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... id 0..1 id Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203357
....... display 1..1 string Representation defined by the system
Fixed Value: Systematic Name
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text Σ 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:sub SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string Generic
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... id 0..1 id Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C97054
....... display 1..1 string Representation defined by the system
Fixed Value: Generic Name
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text Σ 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:brand SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string Brand
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... id 0..1 id Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C71898
....... display 1..1 string Representation defined by the system
Fixed Value: Brand
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text Σ 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:gsrs SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string GSRS Preferred Term
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... id 0..1 id Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203355
....... display 1..1 string Representation defined by the system
Fixed Value: GSRS Preferred Term
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text Σ 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:usp SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string USP-NF Established Name
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... id 0..1 id Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203358
....... display 1..1 string Representation defined by the system
Fixed Value: USP-NF Established Name
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text Σ 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:comp SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string Company ID/Code
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... id 0..1 id Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
...... coding Σ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203354
....... display 1..1 string Representation defined by the system
Fixed Value: Company ID/Code
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text Σ 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:cas SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string CAS Number
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... id 0..1 id Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C54682
....... display 1..1 string Representation defined by the system
Fixed Value: CAS Number
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text Σ 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:inn SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string INN
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... id 0..1 id Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C142585
....... display 1..1 string Representation defined by the system
Fixed Value: INN
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text Σ 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:usan SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string USAN
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... id 0..1 id Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C96973
....... display 1..1 string Representation defined by the system
Fixed Value: USAN
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text Σ 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:iupac SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string IUPAC Name
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... id 0..1 id Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203356
....... display 1..1 string Representation defined by the system
Fixed Value: IUPAC Name
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text Σ 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:isbt SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string ISBT-128 DIN
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.

...... id 0..1 id Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
...... coding SΣ 1..1 Coding Code defined by a terminology system

Required Pattern: At least the following
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C95517
....... display 1..1 string Representation defined by the system
Fixed Value: ISBT-128 DIN
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text Σ 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
... relationship SΣ 0..* BackboneElement A link between this substance and another
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... Slices for substanceDefinition[x] Σ 0..1 A pointer to another substance, as a resource or a representational code
Slice: Unordered, Open by type:$this
..... substanceDefinitionReference Reference(SubstanceDefinition)
..... substanceDefinitionCodeableConcept CodeableConcept
..... substanceDefinition[x]:substanceDefinitionReference Σ 0..1 Reference(Polymorphic Form) The substance definition of a polyphorm of the Drug Substance
.... type Σ 1..1 CodeableConcept For example "salt to parent", "active moiety"
Binding: SubstanceRelationshipType (example): The relationship between two substance types.

..... id 0..1 id Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
..... coding Σ 0..* Coding Code defined by a terminology system
..... text Σ 0..1 string Polymorph
Required Pattern: Polymorph
.... isDefining Σ 0..1 boolean For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible relationships
.... amount[x] Σ 0..1 A numeric factor for the relationship, e.g. that a substance salt has some percentage of active substance in relation to some other
..... amountQuantity Quantity
..... amountRatio Ratio
..... amountString string
.... ratioHighLimitAmount Σ 0..1 Ratio For use when the numeric has an uncertain range
.... comparator Σ 0..1 CodeableConcept An operator for the amount, for example "average", "approximately", "less than"
Binding: SubstanceAmountType (example): The relationship between two substance types.

.... source Σ 0..* Reference(DocumentReference) Supporting literature
... nucleicAcid Σ 0..1 Reference(SubstanceNucleicAcid) Data items specific to nucleic acids
... polymer Σ 0..1 Reference(SubstancePolymer) Data items specific to polymers
... protein Σ 0..1 Reference(SubstanceProtein) Data items specific to proteins
... sourceMaterial Σ 0..1 BackboneElement Material or taxonomic/anatomical source
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... type Σ 0..1 CodeableConcept Classification of the origin of the raw material. e.g. cat hair is an Animal source type
Binding: SourceMaterialType (example): A classification that provides the origin of the substance raw material.

.... genus Σ 0..1 CodeableConcept The genus of an organism e.g. the Latin epithet of the plant/animal scientific name
Binding: SourceMaterialGenus (example): The genus of an organism, typically referring to the Latin epithet of the genus element of the plant/animal scientific name.

.... species Σ 0..1 CodeableConcept The species of an organism e.g. the Latin epithet of the species of the plant/animal
Binding: SourceMaterialSpecies (example): A species of origin a substance raw material.

.... part Σ 0..1 CodeableConcept An anatomical origin of the source material within an organism
Binding: SourceMaterialPart (example): An anatomical origin of the source material within an organism.

.... countryOfOrigin Σ 0..* CodeableConcept The country or countries where the material is harvested
Binding: CountryValueSet (required): Jurisdiction codes



doco Documentation for this format

Terminology Bindings

PathConformanceValueSetURI
SubstanceDefinition.meta.securityextensibleAllSecurityLabels
http://hl7.org/fhir/ValueSet/security-labels
from the FHIR Standard
SubstanceDefinition.meta.tagexampleCommonTags
http://hl7.org/fhir/ValueSet/common-tags
from the FHIR Standard
SubstanceDefinition.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.classificationrequiredSubstanceClassification
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/substance-classification
from this IG
SubstanceDefinition.domainexampleMedicinalProductDomain
http://hl7.org/fhir/ValueSet/medicinal-product-domain
from the FHIR Standard
SubstanceDefinition.gradeexampleSubstanceGrade
http://hl7.org/fhir/ValueSet/substance-grade
from the FHIR Standard
SubstanceDefinition.moiety.stereochemistryexampleStereochemistry
http://hl7.org/fhir/ValueSet/substance-stereochemistry
from the FHIR Standard
SubstanceDefinition.moiety.opticalActivityexampleOpticalActivity
http://hl7.org/fhir/ValueSet/substance-optical-activity
from the FHIR Standard
SubstanceDefinition.moiety.measurementTypeexampleSubstanceAmountType
http://hl7.org/fhir/ValueSet/substance-amount-type
from the FHIR Standard
SubstanceDefinition.characterization.techniqueexampleStructureTechnique
http://hl7.org/fhir/ValueSet/substance-structure-technique
from the FHIR Standard
SubstanceDefinition.characterization.formexampleSubstanceForm
http://hl7.org/fhir/ValueSet/substance-form
from the FHIR Standard
SubstanceDefinition.property.typeexampleProductCharacteristic
http://hl7.org/fhir/ValueSet/product-characteristic-codes
from the FHIR Standard
SubstanceDefinition.molecularWeight.methodexampleWeightMethod
http://hl7.org/fhir/ValueSet/substance-weight-method
from the FHIR Standard
SubstanceDefinition.molecularWeight.typeexampleWeightType
http://hl7.org/fhir/ValueSet/substance-weight-type
from the FHIR Standard
SubstanceDefinition.molecularWeight.amount.comparatorrequiredQuantityComparator
http://hl7.org/fhir/ValueSet/quantity-comparator|5.0.0
from the FHIR Standard
SubstanceDefinition.molecularWeight.amount.coderequiredPqcmcUnitsMeasureTerminology
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-units-of-measure-terminology
from this IG
SubstanceDefinition.structure.stereochemistryexampleStereochemistry
http://hl7.org/fhir/ValueSet/substance-stereochemistry
from the FHIR Standard
SubstanceDefinition.structure.opticalActivityexampleOpticalActivity
http://hl7.org/fhir/ValueSet/substance-optical-activity
from the FHIR Standard
SubstanceDefinition.structure.techniqueexampleStructureTechnique
http://hl7.org/fhir/ValueSet/substance-structure-technique
from the FHIR Standard
SubstanceDefinition.structure.representation.typeexampleSubstanceRepresentationType
http://hl7.org/fhir/ValueSet/substance-representation-type
from the FHIR Standard
SubstanceDefinition.structure.representation.formatexampleSubstanceRepresentationFormat
http://hl7.org/fhir/ValueSet/substance-representation-format
from the FHIR Standard
SubstanceDefinition.structure.representation.format.codingrequiredPqcmcChemicalStructureDataFileTypeTerminology
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-chemical-structure-datafile-type-terminology
from this IG
SubstanceDefinition.code.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:sys.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:sys.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:sys.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name:sys.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name:sys.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name:sys.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name:sys.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:sub.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:sub.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:sub.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name:sub.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name:sub.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name:sub.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name:sub.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:brand.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:brand.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:brand.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name:brand.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name:brand.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name:brand.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name:brand.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:gsrs.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:gsrs.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:gsrs.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name:gsrs.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name:gsrs.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name:gsrs.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name:gsrs.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:usp.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:usp.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:usp.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name:usp.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name:usp.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name:usp.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name:usp.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:comp.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:comp.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:comp.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name:comp.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name:comp.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name:comp.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name:comp.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:cas.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:cas.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:cas.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name:cas.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name:cas.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name:cas.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name:cas.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:inn.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:inn.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:inn.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name:inn.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name:inn.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name:inn.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name:inn.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:usan.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:usan.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:usan.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name:usan.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name:usan.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name:usan.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name:usan.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:iupac.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:iupac.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:iupac.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name:iupac.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name:iupac.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name:iupac.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name:iupac.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:isbt.typeexampleSubstanceNameType
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:isbt.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:isbt.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name:isbt.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name:isbt.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name:isbt.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name:isbt.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.relationship.typeexampleSubstanceRelationshipType
http://hl7.org/fhir/ValueSet/substance-relationship-type
from the FHIR Standard
SubstanceDefinition.relationship.comparatorexampleSubstanceAmountType
http://hl7.org/fhir/ValueSet/substance-amount-type
from the FHIR Standard
SubstanceDefinition.sourceMaterial.typeexampleSourceMaterialType
http://hl7.org/fhir/ValueSet/substance-source-material-type
from the FHIR Standard
SubstanceDefinition.sourceMaterial.genusexampleSourceMaterialGenus
http://hl7.org/fhir/ValueSet/substance-source-material-genus
from the FHIR Standard
SubstanceDefinition.sourceMaterial.speciesexampleSourceMaterialSpecies
http://hl7.org/fhir/ValueSet/substance-source-material-species
from the FHIR Standard
SubstanceDefinition.sourceMaterial.partexampleSourceMaterialPart
http://hl7.org/fhir/ValueSet/substance-source-material-part
from the FHIR Standard
SubstanceDefinition.sourceMaterial.countryOfOriginrequiredCountryValueSet
http://hl7.org/fhir/ValueSet/country|5.0.0
from the FHIR Standard

Constraints

IdGradePath(s)DetailsRequirements
cmc-name-isbterrorSubstanceDefinitionName.type ISBT 128 required for blood products.
: classification.where(coding.where(code = '8' and system = 'http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy').exists()).exists() implies name.type.coding.exists(code = '226' and system = 'http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy')
cmc-name-preferrederrorSubstanceDefinition.nameName.preferred: at most one = true
: select(preferred = true).count() < 2
cmc-structure-requirederrorSubstanceDefinitionA structure is required in code for any of these categories: 'Chemical', 'Mixture', 'Nucleic Acids','Polymer','Protein'.
: classification.coding.where(system = 'http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy' and code in ('C48807' | 'C45305' | 'C706' | 'C48803' |'C17021') ).exists() implies structure.exists()
cmc-substance-structure-graphic-requirederrorSubstanceDefinitionA Substance Structure Graphic is required Required for Small Molecules. Equivalent to classification code equals 'Chemical'.
: (classification.where(coding.where(code = '1' and system = 'http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy').exists()).exists()) implies structure.representation.exists()
cmc-when-unii-requirederrorSubstanceDefinitionA UNII is required in code for any of these categories: 'Chemical', 'Mixture', 'Nucleic Acids','Polymer','Protein'.
: classification.coding.where(system = 'http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy' and code in ('C48807' | 'C45305' | 'C706' | 'C48803' |'C17021') ).exists() implies code.code.text.exists()
dom-2errorSubstanceDefinitionIf the resource is contained in another resource, it SHALL NOT contain nested Resources
: contained.contained.empty()
dom-3errorSubstanceDefinitionIf the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource
: contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().ofType(canonical) | %resource.descendants().ofType(uri) | %resource.descendants().ofType(url))) or descendants().where(reference = '#').exists() or descendants().where(ofType(canonical) = '#').exists() or descendants().where(ofType(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4errorSubstanceDefinitionIf a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated
: contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5errorSubstanceDefinitionIf a resource is contained in another resource, it SHALL NOT have a security label
: contained.meta.security.empty()
dom-6best practiceSubstanceDefinitionA resource should have narrative for robust management
: text.`div`.exists()
ele-1error**ALL** elementsAll FHIR elements must have a @value or children
: hasValue() or (children().count() > id.count())
ext-1error**ALL** extensionsMust have either extensions or value[x], not both
: extension.exists() != value.exists()

This structure is derived from SubstanceDefinition

Summary

Mandatory: 9 elements(26 nested mandatory elements)
Must-Support: 75 elements

Structures

This structure refers to these other structures:

Slices

This structure defines the following Slices:

  • The element 1 is sliced based on the value of SubstanceDefinition.code.code.coding
  • The element 1 is sliced based on the value of SubstanceDefinition.name (Closed)
  • The element 1 is sliced based on the value of SubstanceDefinition.relationship.substanceDefinition[x]

 

Other representations of profile: CSV, Excel, Schematron