Pharmaceutical Quality - Chemistry, Manufacturing and Controls (PQ-CMC) Submissions to FDA
2.0.0-ballot - 2025Jan United States of America flag

Pharmaceutical Quality - Chemistry, Manufacturing and Controls (PQ-CMC) Submissions to FDA, published by HL7 International / Biomedical Research and Regulation. This guide is not an authorized publication; it is the continuous build for version 2.0.0-ballot built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/FHIR-us-pq-cmc-fda/ and changes regularly. See the Directory of published versions

Resource Profile: Drug Substance Impurity

Official URL: http://hl7.org/fhir/us/pq-cmc-fda/StructureDefinition/pqcmc-drug-product-substance-impurity Version: 2.0.0-ballot
Active as of 2024-12-04 Computable Name: ImpuritySubstance
Other Identifiers: OID:2.16.840.1.113883.4.642.40.36.42.44

Any component of the drug substance that is not the chemical entity for procduct composition.

Usage:

Formal Views of Profile Content

Description of Profiles, Differentials, Snapshots and how the different presentations work.

This structure is derived from SubstanceDefinition

NameFlagsCard.TypeDescription & Constraintsdoco
.. SubstanceDefinition C 0..* SubstanceDefinition The detailed description of a substance, typically at a level beyond what is used for prescribing
cmc-impurity-unii-required: If Product Impurity Chemical Structure Data File is not present, then a unii is required
... identifier S 0..1 Identifier optional user designated identifier
... classification S 1..* CodeableConcept Impurity Classification
Binding: Impurity Classification Terminology (required)
... characterization S 0..* BackboneElement General specifications for this substance
.... technique S 0..1 CodeableConceptTextOnly Substance Characterisation Technique
.... description S 0..1 markdown Analysis Narrative Text and Table
.... Slices for file S 0..* Attachment Impurity Analysis Graphic | Impurity Analytical Instrument Data File
Slice: Unordered, Open by profile:$this
..... file:AnalysisGraphic 0..* GraphicAttachment Analysis Graphic
..... file:AnalyticalInstrumentData 0..* AnalyticalInstrumentData Analytical Instrument Data File
.... technique S 0..* CodeableConceptTextOnly Impurity Substance Characterisation Technique
.... Slices for representation S 0..* BackboneElement Impurity Structure Graphic | Impurity Structure Data File
Slice: Unordered, Closed by value:type
..... representation:All Slices Content/Rules for all slices
...... type S 1..1 CodeableConcept The kind of structural representation (e.g. full, partial)
Binding: Representation Types (required)
..... representation:graphic 0..1 BackboneElement A graphical, displayable depiction of the structure (e.g. an SVG, PNG)
...... type 0..1 CodeableConcept Graphic
Required Pattern: At least the following
....... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
........ system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
........ code 1..1 code Symbol in syntax defined by the system
Fixed Value: C54273
...... document 1..1 LiteralReference(Graphic Reference) {b} Impurity Structure Graphic
..... representation:structureFile 0..* BackboneElement machine-readable representation -- attached file
...... type 0..1 CodeableConcept Structure File
Required Pattern: At least the following
....... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
........ system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
........ code 1..1 code Symbol in syntax defined by the system
Fixed Value: C103240
...... document S 1..1 LiteralReference(Structure Data Reference) {b} Impurity Chemical Structure Data (files, e.g. .SDF, .CIF)
..... representation:structureString 0..* BackboneElement machine-readable representation -- plain text
...... type 0..1 CodeableConcept Structure Textual
Required Pattern: At least the following
....... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
........ system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
........ code 1..1 code Symbol in syntax defined by the system
Fixed Value: C45253
...... representation S 1..1 string Impurity Chemical Structure Data (short, plain text representations, e.g. SMILES)
...... format S 1..1 CodeableConcept Drug Substance Impurity Method Type
Binding: Chemical Structure Data File Type Terminology (required)
... Slices for code S 0..* BackboneElement Codes associated with the substance
Slice: Unordered, Open by value:code.coding.system
.... code:unii 0..1 BackboneElement UNII
..... code S 1..1 CodeableConcept The specific code
...... coding S 1..1 Coding Code defined by a terminology system
....... system S 1..1 uri Identity of the terminology system
Required Pattern: http://fdasis.nlm.nih.gov
.... code:uniProt 0..1 BackboneElement UniProt ID
..... code S 1..1 CodeableConcept The specific code
...... coding S 1..1 Coding Code defined by a terminology system
....... system S 1..1 uri Identity of the terminology system
Required Pattern: https://www.uniprot.org
... Slices for name SC 1..* BackboneElement Substance Name
Slice: Unordered, Closed by value:type
cmc-name-preferred: Name.preferred: at most one = true
.... name:All Slices Content/Rules for all slices
..... type 0..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: Substance Name Type (required)
..... preferred S 0..1 boolean True when the name type is Substance Name
.... name:sub S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string Generic Name
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Required Pattern: At least the following
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C97054
....... display 1..1 string Representation defined by the system
Fixed Value: Generic Name
..... preferred S 0..1 boolean If this is the preferred name for this substance
.... name:gsrs S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string GSRS Preferred Term
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Required Pattern: At least the following
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203355
....... display 1..1 string Representation defined by the system
Fixed Value: GSRS Preferred Term
..... preferred S 0..1 boolean If this is the preferred name for this substance
.... name:isbt S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string ISBT-128 DIN
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Required Pattern: At least the following
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C95517
....... display 1..1 string Representation defined by the system
Fixed Value: ISBT-128 DIN
..... preferred S 0..1 boolean If this is the preferred name for this substance
.... name:comp S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string Company ID/Code
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Required Pattern: At least the following
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203354
....... display 1..1 string Representation defined by the system
Fixed Value: Company ID/Code

doco Documentation for this format

Terminology Bindings (Differential)

PathConformanceValueSetURI
SubstanceDefinition.classificationrequiredPqcmcImpurityClassificationTerminology
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-impurity-classification-terminology
from this IG
SubstanceDefinition.structure.representation.typerequiredPqcmcRepresentationTypes
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-representation-types
from this IG
SubstanceDefinition.structure.representation:structureString.formatrequiredPqcmcChemicalStructureDataFileTypeTerminology
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-chemical-structure-datafile-type-terminology
from this IG
SubstanceDefinition.name.typerequiredPqcmcSubstanceNameType
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-substance-name-type
from this IG

Constraints

IdGradePath(s)DetailsRequirements
cmc-impurity-unii-requirederrorSubstanceDefinitionIf Product Impurity Chemical Structure Data File is not present, then a unii is required
: structure.representation.type.coding.where( system = 'http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl' and code = 'C103240' ).exists().not() implies ( code.where( code.coding.exists(system = 'http://fdasis.nlm.nih.gov') ).exists() )
cmc-name-preferrederrorSubstanceDefinition.nameName.preferred: at most one = true
: select(preferred = true).count() < 2
NameFlagsCard.TypeDescription & Constraintsdoco
.. SubstanceDefinition C 0..* SubstanceDefinition The detailed description of a substance, typically at a level beyond what is used for prescribing
cmc-impurity-unii-required: If Product Impurity Chemical Structure Data File is not present, then a unii is required
... implicitRules ?!Σ 0..1 uri A set of rules under which this content was created
... contained 0..* Resource Contained, inline Resources
... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored
... classification SΣ 1..* CodeableConcept Impurity Classification
Binding: Impurity Classification Terminology (required)
... characterization SΣ 0..* BackboneElement General specifications for this substance
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... technique S 0..1 CodeableConceptTextOnly Substance Characterisation Technique
Binding: StructureTechnique (example): The method used to elucidate the characterization of the drug substance.

.... description SΣ 0..1 markdown Analysis Narrative Text and Table
.... Slices for file SΣ 0..* Attachment Impurity Analysis Graphic | Impurity Analytical Instrument Data File
Slice: Unordered, Open by profile:$this
..... file:AnalysisGraphic C 0..* GraphicAttachment Analysis Graphic
att-1: If the Attachment has data, it SHALL have a contentType
..... file:AnalyticalInstrumentData C 0..* AnalyticalInstrumentData Analytical Instrument Data File
att-1: If the Attachment has data, it SHALL have a contentType
... structure SΣ 0..1 BackboneElement Structural information
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... technique S 0..* CodeableConceptTextOnly Impurity Substance Characterisation Technique
Binding: StructureTechnique (example): The method used to elucidate the structure of the drug substance.


.... Slices for representation SΣ 0..* BackboneElement Impurity Structure Graphic | Impurity Structure Data File
Slice: Unordered, Closed by value:type
..... representation:All Slices Content/Rules for all slices
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... type SΣ 1..1 CodeableConcept The kind of structural representation (e.g. full, partial)
Binding: Representation Types (required)
..... representation:graphic Σ 0..1 BackboneElement A graphical, displayable depiction of the structure (e.g. an SVG, PNG)
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... type Σ 0..1 CodeableConcept Graphic
Binding: SubstanceRepresentationType (example): A format of a substance representation.


Required Pattern: At least the following
....... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
........ system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
........ code 1..1 code Symbol in syntax defined by the system
Fixed Value: C54273
...... document Σ 1..1 LiteralReference(Graphic Reference) {b} Impurity Structure Graphic
..... representation:structureFile Σ 0..* BackboneElement machine-readable representation -- attached file
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... type Σ 0..1 CodeableConcept Structure File
Binding: SubstanceRepresentationType (example): A format of a substance representation.


Required Pattern: At least the following
....... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
........ system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
........ code 1..1 code Symbol in syntax defined by the system
Fixed Value: C103240
...... document SΣ 1..1 LiteralReference(Structure Data Reference) {b} Impurity Chemical Structure Data (files, e.g. .SDF, .CIF)
..... representation:structureString Σ 0..* BackboneElement machine-readable representation -- plain text
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... type Σ 0..1 CodeableConcept Structure Textual
Binding: SubstanceRepresentationType (example): A format of a substance representation.


Required Pattern: At least the following
....... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
........ system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
........ code 1..1 code Symbol in syntax defined by the system
Fixed Value: C45253
...... representation SΣ 1..1 string Impurity Chemical Structure Data (short, plain text representations, e.g. SMILES)
...... format SΣ 1..1 CodeableConcept Drug Substance Impurity Method Type
Binding: Chemical Structure Data File Type Terminology (required)
... Slices for code SΣ 0..* BackboneElement Codes associated with the substance
Slice: Unordered, Open by value:code.coding.system
.... code:All Slices Content/Rules for all slices
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... code:unii Σ 0..1 BackboneElement UNII
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... code SΣ 1..1 CodeableConcept The specific code
...... coding SΣ 1..1 Coding Code defined by a terminology system
....... system SΣ 1..1 uri Identity of the terminology system
Required Pattern: http://fdasis.nlm.nih.gov
.... code:uniProt Σ 0..1 BackboneElement UniProt ID
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... code SΣ 1..1 CodeableConcept The specific code
...... coding SΣ 1..1 Coding Code defined by a terminology system
....... system SΣ 1..1 uri Identity of the terminology system
Required Pattern: https://www.uniprot.org
... Slices for name SΣC 1..* BackboneElement Substance Name
Slice: Unordered, Closed by value:type
cmc-name-preferred: Name.preferred: at most one = true
.... name:All Slices Content/Rules for all slices
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name Σ 1..1 string The actual name
..... type Σ 0..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: Substance Name Type (required)
..... preferred SΣ 0..1 boolean True when the name type is Substance Name
.... name:sub SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string Generic Name
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.


Required Pattern: At least the following
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C97054
....... display 1..1 string Representation defined by the system
Fixed Value: Generic Name
..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
.... name:gsrs SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string GSRS Preferred Term
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.


Required Pattern: At least the following
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203355
....... display 1..1 string Representation defined by the system
Fixed Value: GSRS Preferred Term
..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
.... name:isbt SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string ISBT-128 DIN
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.


Required Pattern: At least the following
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C95517
....... display 1..1 string Representation defined by the system
Fixed Value: ISBT-128 DIN
..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
.... name:comp SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string Company ID/Code
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.


Required Pattern: At least the following
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203354
....... display 1..1 string Representation defined by the system
Fixed Value: Company ID/Code

doco Documentation for this format

Terminology Bindings

PathConformanceValueSet / CodeURI
SubstanceDefinition.classificationrequiredPqcmcImpurityClassificationTerminology
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-impurity-classification-terminology
from this IG
SubstanceDefinition.characterization.techniqueexampleStructureTechnique
http://hl7.org/fhir/ValueSet/substance-structure-technique
from the FHIR Standard
SubstanceDefinition.structure.techniqueexampleStructureTechnique
http://hl7.org/fhir/ValueSet/substance-structure-technique
from the FHIR Standard
SubstanceDefinition.structure.representation.typerequiredPqcmcRepresentationTypes
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-representation-types
from this IG
SubstanceDefinition.structure.representation:graphic.typeexamplePattern: C54273
http://hl7.org/fhir/ValueSet/substance-representation-type
from the FHIR Standard
SubstanceDefinition.structure.representation:structureFile.typeexamplePattern: C103240
http://hl7.org/fhir/ValueSet/substance-representation-type
from the FHIR Standard
SubstanceDefinition.structure.representation:structureString.typeexamplePattern: C45253
http://hl7.org/fhir/ValueSet/substance-representation-type
from the FHIR Standard
SubstanceDefinition.structure.representation:structureString.formatrequiredPqcmcChemicalStructureDataFileTypeTerminology
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-chemical-structure-datafile-type-terminology
from this IG
SubstanceDefinition.name.typerequiredPqcmcSubstanceNameType
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-substance-name-type
from this IG
SubstanceDefinition.name:sub.typeexamplePattern: C97054("Generic Name")
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:gsrs.typeexamplePattern: C203355("GSRS Preferred Term")
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:isbt.typeexamplePattern: C95517("ISBT-128 DIN")
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:comp.typeexamplePattern: C203354("Company ID/Code")
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard

Constraints

IdGradePath(s)DetailsRequirements
att-1errorSubstanceDefinition.characterization.file:AnalysisGraphic, SubstanceDefinition.characterization.file:AnalyticalInstrumentDataIf the Attachment has data, it SHALL have a contentType
: data.empty() or contentType.exists()
cmc-impurity-unii-requirederrorSubstanceDefinitionIf Product Impurity Chemical Structure Data File is not present, then a unii is required
: structure.representation.type.coding.where( system = 'http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl' and code = 'C103240' ).exists().not() implies ( code.where( code.coding.exists(system = 'http://fdasis.nlm.nih.gov') ).exists() )
cmc-name-preferrederrorSubstanceDefinition.nameName.preferred: at most one = true
: select(preferred = true).count() < 2
dom-2errorSubstanceDefinitionIf the resource is contained in another resource, it SHALL NOT contain nested Resources
: contained.contained.empty()
dom-3errorSubstanceDefinitionIf the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource
: contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().ofType(canonical) | %resource.descendants().ofType(uri) | %resource.descendants().ofType(url))) or descendants().where(reference = '#').exists() or descendants().where(ofType(canonical) = '#').exists() or descendants().where(ofType(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4errorSubstanceDefinitionIf a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated
: contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5errorSubstanceDefinitionIf a resource is contained in another resource, it SHALL NOT have a security label
: contained.meta.security.empty()
dom-6best practiceSubstanceDefinitionA resource should have narrative for robust management
: text.`div`.exists()
ele-1error**ALL** elementsAll FHIR elements must have a @value or children
: hasValue() or (children().count() > id.count())
ext-1error**ALL** extensionsMust have either extensions or value[x], not both
: extension.exists() != value.exists()
NameFlagsCard.TypeDescription & Constraintsdoco
.. SubstanceDefinition C 0..* SubstanceDefinition The detailed description of a substance, typically at a level beyond what is used for prescribing
cmc-impurity-unii-required: If Product Impurity Chemical Structure Data File is not present, then a unii is required
... id Σ 0..1 id Logical id of this artifact
... meta Σ 0..1 Meta Metadata about the resource
... implicitRules ?!Σ 0..1 uri A set of rules under which this content was created
... language 0..1 code Language of the resource content
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set
... text 0..1 Narrative Text summary of the resource, for human interpretation
... contained 0..* Resource Contained, inline Resources
... extension 0..* Extension Additional content defined by implementations
... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored
... identifier SΣ 0..1 Identifier optional user designated identifier
... version Σ 0..1 string A business level version identifier of the substance
... status Σ 0..1 CodeableConcept Status of substance within the catalogue e.g. active, retired
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

... classification SΣ 1..* CodeableConcept Impurity Classification
Binding: Impurity Classification Terminology (required)
... domain Σ 0..1 CodeableConcept If the substance applies to human or veterinary use
Binding: MedicinalProductDomain (example): Applicable domain for this product (e.g. human, veterinary).

... grade Σ 0..* CodeableConcept The quality standard, established benchmark, to which substance complies (e.g. USP/NF, BP)
Binding: SubstanceGrade (example): The quality standard, established benchmark, to which a substance complies


... description Σ 0..1 markdown Textual description of the substance
... informationSource Σ 0..* Reference(Citation) Supporting literature
... note Σ 0..* Annotation Textual comment about the substance's catalogue or registry record
... manufacturer Σ 0..* Reference(Organization) The entity that creates, makes, produces or fabricates the substance
... supplier Σ 0..* Reference(Organization) An entity that is the source for the substance. It may be different from the manufacturer
... moiety Σ 0..* BackboneElement Moiety, for structural modifications
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... role Σ 0..1 CodeableConcept Role that the moiety is playing
.... identifier Σ 0..1 Identifier Identifier by which this moiety substance is known
.... name Σ 0..1 string Textual name for this moiety substance
.... stereochemistry Σ 0..1 CodeableConcept Stereochemistry type
Binding: Stereochemistry (example): The optical rotation type of a substance.

.... opticalActivity Σ 0..1 CodeableConcept Optical activity type
Binding: OpticalActivity (example): The optical rotation type of a substance.

.... molecularFormula Σ 0..1 string Molecular formula for this moiety (e.g. with the Hill system)
.... amount[x] Σ 0..1 Quantitative value for this moiety
..... amountQuantity Quantity
..... amountString string
.... measurementType Σ 0..1 CodeableConcept The measurement type of the quantitative value
Binding: SubstanceAmountType (example): The relationship between two substance types.

... characterization SΣ 0..* BackboneElement General specifications for this substance
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... technique S 0..1 CodeableConceptTextOnly Substance Characterisation Technique
Binding: StructureTechnique (example): The method used to elucidate the characterization of the drug substance.

.... form Σ 0..1 CodeableConcept Describes the nature of the chemical entity and explains, for instance, whether this is a base or a salt form
Binding: SubstanceForm (example)
.... description SΣ 0..1 markdown Analysis Narrative Text and Table
.... Slices for file SΣ 0..* Attachment Impurity Analysis Graphic | Impurity Analytical Instrument Data File
Slice: Unordered, Open by profile:$this
..... file:AnalysisGraphic C 0..* GraphicAttachment Analysis Graphic
att-1: If the Attachment has data, it SHALL have a contentType
..... file:AnalyticalInstrumentData C 0..* AnalyticalInstrumentData Analytical Instrument Data File
att-1: If the Attachment has data, it SHALL have a contentType
... property Σ 0..* BackboneElement General specifications for this substance
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... type Σ 1..1 CodeableConcept A code expressing the type of property
Binding: ProductCharacteristic (example): This value set includes all observable entity codes from SNOMED CT - provided as an exemplar value set.

.... value[x] Σ 0..1 A value for the property
..... valueCodeableConcept CodeableConcept
..... valueQuantity Quantity
..... valueDate date
..... valueBoolean boolean
..... valueAttachment Attachment
... referenceInformation Σ 0..1 Reference(SubstanceReferenceInformation) General information detailing this substance
... molecularWeight Σ 0..* BackboneElement The average mass of a molecule of a compound
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... method Σ 0..1 CodeableConcept The method by which the weight was determined
Binding: WeightMethod (example): The method by which the substance weight was measured.

.... type Σ 0..1 CodeableConcept Type of molecular weight e.g. exact, average, weight average
Binding: WeightType (example): The type of substance weight measurement.

.... amount Σ 1..1 Quantity Used to capture quantitative values for a variety of elements
... structure SΣ 0..1 BackboneElement Structural information
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... stereochemistry Σ 0..1 CodeableConcept Stereochemistry type
Binding: Stereochemistry (example): The optical rotation type of a substance.

.... opticalActivity Σ 0..1 CodeableConcept Optical activity type
Binding: OpticalActivity (example): The optical rotation type of a substance.

.... molecularFormula Σ 0..1 string An expression which states the number and type of atoms present in a molecule of a substance
.... molecularFormulaByMoiety Σ 0..1 string Specified per moiety according to the Hill system
.... molecularWeight Σ 0..1 See molecularWeight (SubstanceDefinition) The molecular weight or weight range
.... technique S 0..* CodeableConceptTextOnly Impurity Substance Characterisation Technique
Binding: StructureTechnique (example): The method used to elucidate the structure of the drug substance.


.... sourceDocument Σ 0..* Reference(DocumentReference) Source of information for the structure
.... Slices for representation SΣ 0..* BackboneElement Impurity Structure Graphic | Impurity Structure Data File
Slice: Unordered, Closed by value:type
..... representation:All Slices Content/Rules for all slices
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... type SΣ 1..1 CodeableConcept The kind of structural representation (e.g. full, partial)
Binding: Representation Types (required)
...... representation Σ 0..1 string The structural representation as a text string in a standard format
...... format Σ 0..1 CodeableConcept The format of the representation e.g. InChI, SMILES, MOLFILE (note: not the physical file format)
Binding: SubstanceRepresentationFormat (example): A format of a substance representation.

...... document Σ 0..1 Reference(DocumentReference) An attachment with the structural representation e.g. a structure graphic or AnIML file
..... representation:graphic Σ 0..1 BackboneElement A graphical, displayable depiction of the structure (e.g. an SVG, PNG)
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... type Σ 0..1 CodeableConcept Graphic
Binding: SubstanceRepresentationType (example): A format of a substance representation.


Required Pattern: At least the following
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
........ id 0..1 string Unique id for inter-element referencing
........ extension 0..* Extension Additional content defined by implementations
........ system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
........ version 0..1 string Version of the system - if relevant
........ code 1..1 code Symbol in syntax defined by the system
Fixed Value: C54273
........ display 0..1 string Representation defined by the system
........ userSelected 0..1 boolean If this coding was chosen directly by the user
....... text 0..1 string Plain text representation of the concept
...... representation Σ 0..1 string The structural representation as a text string in a standard format
...... format Σ 0..1 CodeableConcept The format of the representation e.g. InChI, SMILES, MOLFILE (note: not the physical file format)
Binding: SubstanceRepresentationFormat (example): A format of a substance representation.

...... document Σ 1..1 LiteralReference(Graphic Reference) {b} Impurity Structure Graphic
..... representation:structureFile Σ 0..* BackboneElement machine-readable representation -- attached file
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... type Σ 0..1 CodeableConcept Structure File
Binding: SubstanceRepresentationType (example): A format of a substance representation.


Required Pattern: At least the following
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
........ id 0..1 string Unique id for inter-element referencing
........ extension 0..* Extension Additional content defined by implementations
........ system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
........ version 0..1 string Version of the system - if relevant
........ code 1..1 code Symbol in syntax defined by the system
Fixed Value: C103240
........ display 0..1 string Representation defined by the system
........ userSelected 0..1 boolean If this coding was chosen directly by the user
....... text 0..1 string Plain text representation of the concept
...... representation Σ 0..1 string The structural representation as a text string in a standard format
...... format Σ 0..1 CodeableConcept The format of the representation e.g. InChI, SMILES, MOLFILE (note: not the physical file format)
Binding: SubstanceRepresentationFormat (example): A format of a substance representation.

...... document SΣ 1..1 LiteralReference(Structure Data Reference) {b} Impurity Chemical Structure Data (files, e.g. .SDF, .CIF)
..... representation:structureString Σ 0..* BackboneElement machine-readable representation -- plain text
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... type Σ 0..1 CodeableConcept Structure Textual
Binding: SubstanceRepresentationType (example): A format of a substance representation.


Required Pattern: At least the following
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
........ id 0..1 string Unique id for inter-element referencing
........ extension 0..* Extension Additional content defined by implementations
........ system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
........ version 0..1 string Version of the system - if relevant
........ code 1..1 code Symbol in syntax defined by the system
Fixed Value: C45253
........ display 0..1 string Representation defined by the system
........ userSelected 0..1 boolean If this coding was chosen directly by the user
....... text 0..1 string Plain text representation of the concept
...... representation SΣ 1..1 string Impurity Chemical Structure Data (short, plain text representations, e.g. SMILES)
...... format SΣ 1..1 CodeableConcept Drug Substance Impurity Method Type
Binding: Chemical Structure Data File Type Terminology (required)
...... document Σ 0..1 Reference(DocumentReference) An attachment with the structural representation e.g. a structure graphic or AnIML file
... Slices for code SΣ 0..* BackboneElement Codes associated with the substance
Slice: Unordered, Open by value:code.coding.system
.... code:All Slices Content/Rules for all slices
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... code Σ 0..1 CodeableConcept The specific code
..... status Σ 0..1 CodeableConcept Status of the code assignment, for example 'provisional', 'approved'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... statusDate Σ 0..1 dateTime The date at which the code status was changed
..... note Σ 0..* Annotation Any comment can be provided in this field
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... code:unii Σ 0..1 BackboneElement UNII
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... code SΣ 1..1 CodeableConcept The specific code
...... id 0..1 id Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
...... coding SΣ 1..1 Coding Code defined by a terminology system
....... id 0..1 id Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
....... system SΣ 1..1 uri Identity of the terminology system
Required Pattern: http://fdasis.nlm.nih.gov
....... version Σ 0..1 string Version of the system - if relevant
....... code ΣC 0..1 code Symbol in syntax defined by the system
....... display ΣC 0..1 string Representation defined by the system
....... userSelected Σ 0..1 boolean If this coding was chosen directly by the user
...... text Σ 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept Status of the code assignment, for example 'provisional', 'approved'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... statusDate Σ 0..1 dateTime The date at which the code status was changed
..... note Σ 0..* Annotation Any comment can be provided in this field
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... code:uniProt Σ 0..1 BackboneElement UniProt ID
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... code SΣ 1..1 CodeableConcept The specific code
...... id 0..1 id Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
...... coding SΣ 1..1 Coding Code defined by a terminology system
....... id 0..1 id Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
....... system SΣ 1..1 uri Identity of the terminology system
Required Pattern: https://www.uniprot.org
....... version Σ 0..1 string Version of the system - if relevant
....... code ΣC 0..1 code Symbol in syntax defined by the system
....... display ΣC 0..1 string Representation defined by the system
....... userSelected Σ 0..1 boolean If this coding was chosen directly by the user
...... text Σ 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept Status of the code assignment, for example 'provisional', 'approved'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... statusDate Σ 0..1 dateTime The date at which the code status was changed
..... note Σ 0..* Annotation Any comment can be provided in this field
..... source Σ 0..* Reference(DocumentReference) Supporting literature
... Slices for name SΣC 1..* BackboneElement Substance Name
Slice: Unordered, Closed by value:type
cmc-name-preferred: Name.preferred: at most one = true
.... name:All Slices Content/Rules for all slices
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name Σ 1..1 string The actual name
..... type Σ 0..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: Substance Name Type (required)
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred SΣ 0..1 boolean True when the name type is Substance Name
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:sub SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string Generic Name
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.


Required Pattern: At least the following
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C97054
....... display 1..1 string Representation defined by the system
Fixed Value: Generic Name
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:gsrs SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string GSRS Preferred Term
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.


Required Pattern: At least the following
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203355
....... display 1..1 string Representation defined by the system
Fixed Value: GSRS Preferred Term
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:isbt SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string ISBT-128 DIN
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.


Required Pattern: At least the following
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C95517
....... display 1..1 string Representation defined by the system
Fixed Value: ISBT-128 DIN
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:comp SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string Company ID/Code
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.


Required Pattern: At least the following
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203354
....... display 1..1 string Representation defined by the system
Fixed Value: Company ID/Code
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred Σ 0..1 boolean If this is the preferred name for this substance
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
... relationship Σ 0..* BackboneElement A link between this substance and another
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... substanceDefinition[x] Σ 0..1 A pointer to another substance, as a resource or a representational code
..... substanceDefinitionReference Reference(SubstanceDefinition)
..... substanceDefinitionCodeableConcept CodeableConcept
.... type Σ 1..1 CodeableConcept For example "salt to parent", "active moiety"
Binding: SubstanceRelationshipType (example): The relationship between two substance types.

.... isDefining Σ 0..1 boolean For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible relationships
.... amount[x] Σ 0..1 A numeric factor for the relationship, e.g. that a substance salt has some percentage of active substance in relation to some other
..... amountQuantity Quantity
..... amountRatio Ratio
..... amountString string
.... ratioHighLimitAmount Σ 0..1 Ratio For use when the numeric has an uncertain range
.... comparator Σ 0..1 CodeableConcept An operator for the amount, for example "average", "approximately", "less than"
Binding: SubstanceAmountType (example): The relationship between two substance types.

.... source Σ 0..* Reference(DocumentReference) Supporting literature
... nucleicAcid Σ 0..1 Reference(SubstanceNucleicAcid) Data items specific to nucleic acids
... polymer Σ 0..1 Reference(SubstancePolymer) Data items specific to polymers
... protein Σ 0..1 Reference(SubstanceProtein) Data items specific to proteins
... sourceMaterial Σ 0..1 BackboneElement Material or taxonomic/anatomical source
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... type Σ 0..1 CodeableConcept Classification of the origin of the raw material. e.g. cat hair is an Animal source type
Binding: SourceMaterialType (example): A classification that provides the origin of the substance raw material.

.... genus Σ 0..1 CodeableConcept The genus of an organism e.g. the Latin epithet of the plant/animal scientific name
Binding: SourceMaterialGenus (example): The genus of an organism, typically referring to the Latin epithet of the genus element of the plant/animal scientific name.

.... species Σ 0..1 CodeableConcept The species of an organism e.g. the Latin epithet of the species of the plant/animal
Binding: SourceMaterialSpecies (example): A species of origin a substance raw material.

.... part Σ 0..1 CodeableConcept An anatomical origin of the source material within an organism
Binding: SourceMaterialPart (example): An anatomical origin of the source material within an organism.

.... countryOfOrigin Σ 0..* CodeableConcept The country or countries where the material is harvested
Binding: CountryValueSet (required): Jurisdiction codes



doco Documentation for this format

Terminology Bindings

PathConformanceValueSet / CodeURI
SubstanceDefinition.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.classificationrequiredPqcmcImpurityClassificationTerminology
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-impurity-classification-terminology
from this IG
SubstanceDefinition.domainexampleMedicinalProductDomain
http://hl7.org/fhir/ValueSet/medicinal-product-domain
from the FHIR Standard
SubstanceDefinition.gradeexampleSubstanceGrade
http://hl7.org/fhir/ValueSet/substance-grade
from the FHIR Standard
SubstanceDefinition.moiety.stereochemistryexampleStereochemistry
http://hl7.org/fhir/ValueSet/substance-stereochemistry
from the FHIR Standard
SubstanceDefinition.moiety.opticalActivityexampleOpticalActivity
http://hl7.org/fhir/ValueSet/substance-optical-activity
from the FHIR Standard
SubstanceDefinition.moiety.measurementTypeexampleSubstanceAmountType
http://hl7.org/fhir/ValueSet/substance-amount-type
from the FHIR Standard
SubstanceDefinition.characterization.techniqueexampleStructureTechnique
http://hl7.org/fhir/ValueSet/substance-structure-technique
from the FHIR Standard
SubstanceDefinition.characterization.formexampleSubstanceForm
http://hl7.org/fhir/ValueSet/substance-form
from the FHIR Standard
SubstanceDefinition.property.typeexampleProductCharacteristic
http://hl7.org/fhir/ValueSet/product-characteristic-codes
from the FHIR Standard
SubstanceDefinition.molecularWeight.methodexampleWeightMethod
http://hl7.org/fhir/ValueSet/substance-weight-method
from the FHIR Standard
SubstanceDefinition.molecularWeight.typeexampleWeightType
http://hl7.org/fhir/ValueSet/substance-weight-type
from the FHIR Standard
SubstanceDefinition.structure.stereochemistryexampleStereochemistry
http://hl7.org/fhir/ValueSet/substance-stereochemistry
from the FHIR Standard
SubstanceDefinition.structure.opticalActivityexampleOpticalActivity
http://hl7.org/fhir/ValueSet/substance-optical-activity
from the FHIR Standard
SubstanceDefinition.structure.techniqueexampleStructureTechnique
http://hl7.org/fhir/ValueSet/substance-structure-technique
from the FHIR Standard
SubstanceDefinition.structure.representation.typerequiredPqcmcRepresentationTypes
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-representation-types
from this IG
SubstanceDefinition.structure.representation.formatexampleSubstanceRepresentationFormat
http://hl7.org/fhir/ValueSet/substance-representation-format
from the FHIR Standard
SubstanceDefinition.structure.representation:graphic.typeexamplePattern: C54273
http://hl7.org/fhir/ValueSet/substance-representation-type
from the FHIR Standard
SubstanceDefinition.structure.representation:graphic.formatexampleSubstanceRepresentationFormat
http://hl7.org/fhir/ValueSet/substance-representation-format
from the FHIR Standard
SubstanceDefinition.structure.representation:structureFile.typeexamplePattern: C103240
http://hl7.org/fhir/ValueSet/substance-representation-type
from the FHIR Standard
SubstanceDefinition.structure.representation:structureFile.formatexampleSubstanceRepresentationFormat
http://hl7.org/fhir/ValueSet/substance-representation-format
from the FHIR Standard
SubstanceDefinition.structure.representation:structureString.typeexamplePattern: C45253
http://hl7.org/fhir/ValueSet/substance-representation-type
from the FHIR Standard
SubstanceDefinition.structure.representation:structureString.formatrequiredPqcmcChemicalStructureDataFileTypeTerminology
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-chemical-structure-datafile-type-terminology
from this IG
SubstanceDefinition.code.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.code:unii.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.code:uniProt.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name.typerequiredPqcmcSubstanceNameType
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-substance-name-type
from this IG
SubstanceDefinition.name.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:sub.typeexamplePattern: C97054("Generic Name")
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:sub.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:sub.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name:sub.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name:sub.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name:sub.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name:sub.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:gsrs.typeexamplePattern: C203355("GSRS Preferred Term")
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:gsrs.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:gsrs.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name:gsrs.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name:gsrs.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name:gsrs.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name:gsrs.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:isbt.typeexamplePattern: C95517("ISBT-128 DIN")
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:isbt.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:isbt.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name:isbt.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name:isbt.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name:isbt.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name:isbt.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:comp.typeexamplePattern: C203354("Company ID/Code")
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:comp.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:comp.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name:comp.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name:comp.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name:comp.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name:comp.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.relationship.typeexampleSubstanceRelationshipType
http://hl7.org/fhir/ValueSet/substance-relationship-type
from the FHIR Standard
SubstanceDefinition.relationship.comparatorexampleSubstanceAmountType
http://hl7.org/fhir/ValueSet/substance-amount-type
from the FHIR Standard
SubstanceDefinition.sourceMaterial.typeexampleSourceMaterialType
http://hl7.org/fhir/ValueSet/substance-source-material-type
from the FHIR Standard
SubstanceDefinition.sourceMaterial.genusexampleSourceMaterialGenus
http://hl7.org/fhir/ValueSet/substance-source-material-genus
from the FHIR Standard
SubstanceDefinition.sourceMaterial.speciesexampleSourceMaterialSpecies
http://hl7.org/fhir/ValueSet/substance-source-material-species
from the FHIR Standard
SubstanceDefinition.sourceMaterial.partexampleSourceMaterialPart
http://hl7.org/fhir/ValueSet/substance-source-material-part
from the FHIR Standard
SubstanceDefinition.sourceMaterial.countryOfOriginrequiredCountryValueSet
http://hl7.org/fhir/ValueSet/country|5.0.0
from the FHIR Standard

Constraints

IdGradePath(s)DetailsRequirements
att-1errorSubstanceDefinition.characterization.file:AnalysisGraphic, SubstanceDefinition.characterization.file:AnalyticalInstrumentDataIf the Attachment has data, it SHALL have a contentType
: data.empty() or contentType.exists()
cmc-impurity-unii-requirederrorSubstanceDefinitionIf Product Impurity Chemical Structure Data File is not present, then a unii is required
: structure.representation.type.coding.where( system = 'http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl' and code = 'C103240' ).exists().not() implies ( code.where( code.coding.exists(system = 'http://fdasis.nlm.nih.gov') ).exists() )
cmc-name-preferrederrorSubstanceDefinition.nameName.preferred: at most one = true
: select(preferred = true).count() < 2
dom-2errorSubstanceDefinitionIf the resource is contained in another resource, it SHALL NOT contain nested Resources
: contained.contained.empty()
dom-3errorSubstanceDefinitionIf the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource
: contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().ofType(canonical) | %resource.descendants().ofType(uri) | %resource.descendants().ofType(url))) or descendants().where(reference = '#').exists() or descendants().where(ofType(canonical) = '#').exists() or descendants().where(ofType(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4errorSubstanceDefinitionIf a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated
: contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5errorSubstanceDefinitionIf a resource is contained in another resource, it SHALL NOT have a security label
: contained.meta.security.empty()
dom-6best practiceSubstanceDefinitionA resource should have narrative for robust management
: text.`div`.exists()
ele-1error**ALL** elementsAll FHIR elements must have a @value or children
: hasValue() or (children().count() > id.count())
ext-1error**ALL** extensionsMust have either extensions or value[x], not both
: extension.exists() != value.exists()

This structure is derived from SubstanceDefinition

Summary

Mandatory: 2 elements(15 nested mandatory elements)
Must-Support: 37 elements

Structures

This structure refers to these other structures:

Slices

This structure defines the following Slices:

  • The element 1 is sliced based on the value of SubstanceDefinition.characterization.file
  • The element 1 is sliced based on the value of SubstanceDefinition.structure.representation (Closed)
  • The element 1 is sliced based on the value of SubstanceDefinition.code
  • The element 1 is sliced based on the value of SubstanceDefinition.name (Closed)

Differential View

This structure is derived from SubstanceDefinition

NameFlagsCard.TypeDescription & Constraintsdoco
.. SubstanceDefinition C 0..* SubstanceDefinition The detailed description of a substance, typically at a level beyond what is used for prescribing
cmc-impurity-unii-required: If Product Impurity Chemical Structure Data File is not present, then a unii is required
... identifier S 0..1 Identifier optional user designated identifier
... classification S 1..* CodeableConcept Impurity Classification
Binding: Impurity Classification Terminology (required)
... characterization S 0..* BackboneElement General specifications for this substance
.... technique S 0..1 CodeableConceptTextOnly Substance Characterisation Technique
.... description S 0..1 markdown Analysis Narrative Text and Table
.... Slices for file S 0..* Attachment Impurity Analysis Graphic | Impurity Analytical Instrument Data File
Slice: Unordered, Open by profile:$this
..... file:AnalysisGraphic 0..* GraphicAttachment Analysis Graphic
..... file:AnalyticalInstrumentData 0..* AnalyticalInstrumentData Analytical Instrument Data File
.... technique S 0..* CodeableConceptTextOnly Impurity Substance Characterisation Technique
.... Slices for representation S 0..* BackboneElement Impurity Structure Graphic | Impurity Structure Data File
Slice: Unordered, Closed by value:type
..... representation:All Slices Content/Rules for all slices
...... type S 1..1 CodeableConcept The kind of structural representation (e.g. full, partial)
Binding: Representation Types (required)
..... representation:graphic 0..1 BackboneElement A graphical, displayable depiction of the structure (e.g. an SVG, PNG)
...... type 0..1 CodeableConcept Graphic
Required Pattern: At least the following
....... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
........ system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
........ code 1..1 code Symbol in syntax defined by the system
Fixed Value: C54273
...... document 1..1 LiteralReference(Graphic Reference) {b} Impurity Structure Graphic
..... representation:structureFile 0..* BackboneElement machine-readable representation -- attached file
...... type 0..1 CodeableConcept Structure File
Required Pattern: At least the following
....... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
........ system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
........ code 1..1 code Symbol in syntax defined by the system
Fixed Value: C103240
...... document S 1..1 LiteralReference(Structure Data Reference) {b} Impurity Chemical Structure Data (files, e.g. .SDF, .CIF)
..... representation:structureString 0..* BackboneElement machine-readable representation -- plain text
...... type 0..1 CodeableConcept Structure Textual
Required Pattern: At least the following
....... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
........ system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
........ code 1..1 code Symbol in syntax defined by the system
Fixed Value: C45253
...... representation S 1..1 string Impurity Chemical Structure Data (short, plain text representations, e.g. SMILES)
...... format S 1..1 CodeableConcept Drug Substance Impurity Method Type
Binding: Chemical Structure Data File Type Terminology (required)
... Slices for code S 0..* BackboneElement Codes associated with the substance
Slice: Unordered, Open by value:code.coding.system
.... code:unii 0..1 BackboneElement UNII
..... code S 1..1 CodeableConcept The specific code
...... coding S 1..1 Coding Code defined by a terminology system
....... system S 1..1 uri Identity of the terminology system
Required Pattern: http://fdasis.nlm.nih.gov
.... code:uniProt 0..1 BackboneElement UniProt ID
..... code S 1..1 CodeableConcept The specific code
...... coding S 1..1 Coding Code defined by a terminology system
....... system S 1..1 uri Identity of the terminology system
Required Pattern: https://www.uniprot.org
... Slices for name SC 1..* BackboneElement Substance Name
Slice: Unordered, Closed by value:type
cmc-name-preferred: Name.preferred: at most one = true
.... name:All Slices Content/Rules for all slices
..... type 0..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: Substance Name Type (required)
..... preferred S 0..1 boolean True when the name type is Substance Name
.... name:sub S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string Generic Name
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Required Pattern: At least the following
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C97054
....... display 1..1 string Representation defined by the system
Fixed Value: Generic Name
..... preferred S 0..1 boolean If this is the preferred name for this substance
.... name:gsrs S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string GSRS Preferred Term
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Required Pattern: At least the following
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203355
....... display 1..1 string Representation defined by the system
Fixed Value: GSRS Preferred Term
..... preferred S 0..1 boolean If this is the preferred name for this substance
.... name:isbt S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string ISBT-128 DIN
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Required Pattern: At least the following
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C95517
....... display 1..1 string Representation defined by the system
Fixed Value: ISBT-128 DIN
..... preferred S 0..1 boolean If this is the preferred name for this substance
.... name:comp S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string Company ID/Code
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Required Pattern: At least the following
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203354
....... display 1..1 string Representation defined by the system
Fixed Value: Company ID/Code

doco Documentation for this format

Terminology Bindings (Differential)

PathConformanceValueSetURI
SubstanceDefinition.classificationrequiredPqcmcImpurityClassificationTerminology
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-impurity-classification-terminology
from this IG
SubstanceDefinition.structure.representation.typerequiredPqcmcRepresentationTypes
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-representation-types
from this IG
SubstanceDefinition.structure.representation:structureString.formatrequiredPqcmcChemicalStructureDataFileTypeTerminology
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-chemical-structure-datafile-type-terminology
from this IG
SubstanceDefinition.name.typerequiredPqcmcSubstanceNameType
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-substance-name-type
from this IG

Constraints

IdGradePath(s)DetailsRequirements
cmc-impurity-unii-requirederrorSubstanceDefinitionIf Product Impurity Chemical Structure Data File is not present, then a unii is required
: structure.representation.type.coding.where( system = 'http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl' and code = 'C103240' ).exists().not() implies ( code.where( code.coding.exists(system = 'http://fdasis.nlm.nih.gov') ).exists() )
cmc-name-preferrederrorSubstanceDefinition.nameName.preferred: at most one = true
: select(preferred = true).count() < 2

Key Elements View

NameFlagsCard.TypeDescription & Constraintsdoco
.. SubstanceDefinition C 0..* SubstanceDefinition The detailed description of a substance, typically at a level beyond what is used for prescribing
cmc-impurity-unii-required: If Product Impurity Chemical Structure Data File is not present, then a unii is required
... implicitRules ?!Σ 0..1 uri A set of rules under which this content was created
... contained 0..* Resource Contained, inline Resources
... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored
... classification SΣ 1..* CodeableConcept Impurity Classification
Binding: Impurity Classification Terminology (required)
... characterization SΣ 0..* BackboneElement General specifications for this substance
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... technique S 0..1 CodeableConceptTextOnly Substance Characterisation Technique
Binding: StructureTechnique (example): The method used to elucidate the characterization of the drug substance.

.... description SΣ 0..1 markdown Analysis Narrative Text and Table
.... Slices for file SΣ 0..* Attachment Impurity Analysis Graphic | Impurity Analytical Instrument Data File
Slice: Unordered, Open by profile:$this
..... file:AnalysisGraphic C 0..* GraphicAttachment Analysis Graphic
att-1: If the Attachment has data, it SHALL have a contentType
..... file:AnalyticalInstrumentData C 0..* AnalyticalInstrumentData Analytical Instrument Data File
att-1: If the Attachment has data, it SHALL have a contentType
... structure SΣ 0..1 BackboneElement Structural information
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... technique S 0..* CodeableConceptTextOnly Impurity Substance Characterisation Technique
Binding: StructureTechnique (example): The method used to elucidate the structure of the drug substance.


.... Slices for representation SΣ 0..* BackboneElement Impurity Structure Graphic | Impurity Structure Data File
Slice: Unordered, Closed by value:type
..... representation:All Slices Content/Rules for all slices
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... type SΣ 1..1 CodeableConcept The kind of structural representation (e.g. full, partial)
Binding: Representation Types (required)
..... representation:graphic Σ 0..1 BackboneElement A graphical, displayable depiction of the structure (e.g. an SVG, PNG)
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... type Σ 0..1 CodeableConcept Graphic
Binding: SubstanceRepresentationType (example): A format of a substance representation.


Required Pattern: At least the following
....... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
........ system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
........ code 1..1 code Symbol in syntax defined by the system
Fixed Value: C54273
...... document Σ 1..1 LiteralReference(Graphic Reference) {b} Impurity Structure Graphic
..... representation:structureFile Σ 0..* BackboneElement machine-readable representation -- attached file
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... type Σ 0..1 CodeableConcept Structure File
Binding: SubstanceRepresentationType (example): A format of a substance representation.


Required Pattern: At least the following
....... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
........ system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
........ code 1..1 code Symbol in syntax defined by the system
Fixed Value: C103240
...... document SΣ 1..1 LiteralReference(Structure Data Reference) {b} Impurity Chemical Structure Data (files, e.g. .SDF, .CIF)
..... representation:structureString Σ 0..* BackboneElement machine-readable representation -- plain text
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... type Σ 0..1 CodeableConcept Structure Textual
Binding: SubstanceRepresentationType (example): A format of a substance representation.


Required Pattern: At least the following
....... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
........ system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
........ code 1..1 code Symbol in syntax defined by the system
Fixed Value: C45253
...... representation SΣ 1..1 string Impurity Chemical Structure Data (short, plain text representations, e.g. SMILES)
...... format SΣ 1..1 CodeableConcept Drug Substance Impurity Method Type
Binding: Chemical Structure Data File Type Terminology (required)
... Slices for code SΣ 0..* BackboneElement Codes associated with the substance
Slice: Unordered, Open by value:code.coding.system
.... code:All Slices Content/Rules for all slices
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... code:unii Σ 0..1 BackboneElement UNII
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... code SΣ 1..1 CodeableConcept The specific code
...... coding SΣ 1..1 Coding Code defined by a terminology system
....... system SΣ 1..1 uri Identity of the terminology system
Required Pattern: http://fdasis.nlm.nih.gov
.... code:uniProt Σ 0..1 BackboneElement UniProt ID
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... code SΣ 1..1 CodeableConcept The specific code
...... coding SΣ 1..1 Coding Code defined by a terminology system
....... system SΣ 1..1 uri Identity of the terminology system
Required Pattern: https://www.uniprot.org
... Slices for name SΣC 1..* BackboneElement Substance Name
Slice: Unordered, Closed by value:type
cmc-name-preferred: Name.preferred: at most one = true
.... name:All Slices Content/Rules for all slices
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name Σ 1..1 string The actual name
..... type Σ 0..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: Substance Name Type (required)
..... preferred SΣ 0..1 boolean True when the name type is Substance Name
.... name:sub SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string Generic Name
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.


Required Pattern: At least the following
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C97054
....... display 1..1 string Representation defined by the system
Fixed Value: Generic Name
..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
.... name:gsrs SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string GSRS Preferred Term
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.


Required Pattern: At least the following
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203355
....... display 1..1 string Representation defined by the system
Fixed Value: GSRS Preferred Term
..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
.... name:isbt SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string ISBT-128 DIN
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.


Required Pattern: At least the following
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C95517
....... display 1..1 string Representation defined by the system
Fixed Value: ISBT-128 DIN
..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
.... name:comp SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string Company ID/Code
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.


Required Pattern: At least the following
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203354
....... display 1..1 string Representation defined by the system
Fixed Value: Company ID/Code

doco Documentation for this format

Terminology Bindings

PathConformanceValueSet / CodeURI
SubstanceDefinition.classificationrequiredPqcmcImpurityClassificationTerminology
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-impurity-classification-terminology
from this IG
SubstanceDefinition.characterization.techniqueexampleStructureTechnique
http://hl7.org/fhir/ValueSet/substance-structure-technique
from the FHIR Standard
SubstanceDefinition.structure.techniqueexampleStructureTechnique
http://hl7.org/fhir/ValueSet/substance-structure-technique
from the FHIR Standard
SubstanceDefinition.structure.representation.typerequiredPqcmcRepresentationTypes
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-representation-types
from this IG
SubstanceDefinition.structure.representation:graphic.typeexamplePattern: C54273
http://hl7.org/fhir/ValueSet/substance-representation-type
from the FHIR Standard
SubstanceDefinition.structure.representation:structureFile.typeexamplePattern: C103240
http://hl7.org/fhir/ValueSet/substance-representation-type
from the FHIR Standard
SubstanceDefinition.structure.representation:structureString.typeexamplePattern: C45253
http://hl7.org/fhir/ValueSet/substance-representation-type
from the FHIR Standard
SubstanceDefinition.structure.representation:structureString.formatrequiredPqcmcChemicalStructureDataFileTypeTerminology
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-chemical-structure-datafile-type-terminology
from this IG
SubstanceDefinition.name.typerequiredPqcmcSubstanceNameType
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-substance-name-type
from this IG
SubstanceDefinition.name:sub.typeexamplePattern: C97054("Generic Name")
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:gsrs.typeexamplePattern: C203355("GSRS Preferred Term")
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:isbt.typeexamplePattern: C95517("ISBT-128 DIN")
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:comp.typeexamplePattern: C203354("Company ID/Code")
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard

Constraints

IdGradePath(s)DetailsRequirements
att-1errorSubstanceDefinition.characterization.file:AnalysisGraphic, SubstanceDefinition.characterization.file:AnalyticalInstrumentDataIf the Attachment has data, it SHALL have a contentType
: data.empty() or contentType.exists()
cmc-impurity-unii-requirederrorSubstanceDefinitionIf Product Impurity Chemical Structure Data File is not present, then a unii is required
: structure.representation.type.coding.where( system = 'http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl' and code = 'C103240' ).exists().not() implies ( code.where( code.coding.exists(system = 'http://fdasis.nlm.nih.gov') ).exists() )
cmc-name-preferrederrorSubstanceDefinition.nameName.preferred: at most one = true
: select(preferred = true).count() < 2
dom-2errorSubstanceDefinitionIf the resource is contained in another resource, it SHALL NOT contain nested Resources
: contained.contained.empty()
dom-3errorSubstanceDefinitionIf the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource
: contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().ofType(canonical) | %resource.descendants().ofType(uri) | %resource.descendants().ofType(url))) or descendants().where(reference = '#').exists() or descendants().where(ofType(canonical) = '#').exists() or descendants().where(ofType(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4errorSubstanceDefinitionIf a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated
: contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5errorSubstanceDefinitionIf a resource is contained in another resource, it SHALL NOT have a security label
: contained.meta.security.empty()
dom-6best practiceSubstanceDefinitionA resource should have narrative for robust management
: text.`div`.exists()
ele-1error**ALL** elementsAll FHIR elements must have a @value or children
: hasValue() or (children().count() > id.count())
ext-1error**ALL** extensionsMust have either extensions or value[x], not both
: extension.exists() != value.exists()

Snapshot View

NameFlagsCard.TypeDescription & Constraintsdoco
.. SubstanceDefinition C 0..* SubstanceDefinition The detailed description of a substance, typically at a level beyond what is used for prescribing
cmc-impurity-unii-required: If Product Impurity Chemical Structure Data File is not present, then a unii is required
... id Σ 0..1 id Logical id of this artifact
... meta Σ 0..1 Meta Metadata about the resource
... implicitRules ?!Σ 0..1 uri A set of rules under which this content was created
... language 0..1 code Language of the resource content
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set
... text 0..1 Narrative Text summary of the resource, for human interpretation
... contained 0..* Resource Contained, inline Resources
... extension 0..* Extension Additional content defined by implementations
... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored
... identifier SΣ 0..1 Identifier optional user designated identifier
... version Σ 0..1 string A business level version identifier of the substance
... status Σ 0..1 CodeableConcept Status of substance within the catalogue e.g. active, retired
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

... classification SΣ 1..* CodeableConcept Impurity Classification
Binding: Impurity Classification Terminology (required)
... domain Σ 0..1 CodeableConcept If the substance applies to human or veterinary use
Binding: MedicinalProductDomain (example): Applicable domain for this product (e.g. human, veterinary).

... grade Σ 0..* CodeableConcept The quality standard, established benchmark, to which substance complies (e.g. USP/NF, BP)
Binding: SubstanceGrade (example): The quality standard, established benchmark, to which a substance complies


... description Σ 0..1 markdown Textual description of the substance
... informationSource Σ 0..* Reference(Citation) Supporting literature
... note Σ 0..* Annotation Textual comment about the substance's catalogue or registry record
... manufacturer Σ 0..* Reference(Organization) The entity that creates, makes, produces or fabricates the substance
... supplier Σ 0..* Reference(Organization) An entity that is the source for the substance. It may be different from the manufacturer
... moiety Σ 0..* BackboneElement Moiety, for structural modifications
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... role Σ 0..1 CodeableConcept Role that the moiety is playing
.... identifier Σ 0..1 Identifier Identifier by which this moiety substance is known
.... name Σ 0..1 string Textual name for this moiety substance
.... stereochemistry Σ 0..1 CodeableConcept Stereochemistry type
Binding: Stereochemistry (example): The optical rotation type of a substance.

.... opticalActivity Σ 0..1 CodeableConcept Optical activity type
Binding: OpticalActivity (example): The optical rotation type of a substance.

.... molecularFormula Σ 0..1 string Molecular formula for this moiety (e.g. with the Hill system)
.... amount[x] Σ 0..1 Quantitative value for this moiety
..... amountQuantity Quantity
..... amountString string
.... measurementType Σ 0..1 CodeableConcept The measurement type of the quantitative value
Binding: SubstanceAmountType (example): The relationship between two substance types.

... characterization SΣ 0..* BackboneElement General specifications for this substance
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... technique S 0..1 CodeableConceptTextOnly Substance Characterisation Technique
Binding: StructureTechnique (example): The method used to elucidate the characterization of the drug substance.

.... form Σ 0..1 CodeableConcept Describes the nature of the chemical entity and explains, for instance, whether this is a base or a salt form
Binding: SubstanceForm (example)
.... description SΣ 0..1 markdown Analysis Narrative Text and Table
.... Slices for file SΣ 0..* Attachment Impurity Analysis Graphic | Impurity Analytical Instrument Data File
Slice: Unordered, Open by profile:$this
..... file:AnalysisGraphic C 0..* GraphicAttachment Analysis Graphic
att-1: If the Attachment has data, it SHALL have a contentType
..... file:AnalyticalInstrumentData C 0..* AnalyticalInstrumentData Analytical Instrument Data File
att-1: If the Attachment has data, it SHALL have a contentType
... property Σ 0..* BackboneElement General specifications for this substance
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... type Σ 1..1 CodeableConcept A code expressing the type of property
Binding: ProductCharacteristic (example): This value set includes all observable entity codes from SNOMED CT - provided as an exemplar value set.

.... value[x] Σ 0..1 A value for the property
..... valueCodeableConcept CodeableConcept
..... valueQuantity Quantity
..... valueDate date
..... valueBoolean boolean
..... valueAttachment Attachment
... referenceInformation Σ 0..1 Reference(SubstanceReferenceInformation) General information detailing this substance
... molecularWeight Σ 0..* BackboneElement The average mass of a molecule of a compound
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... method Σ 0..1 CodeableConcept The method by which the weight was determined
Binding: WeightMethod (example): The method by which the substance weight was measured.

.... type Σ 0..1 CodeableConcept Type of molecular weight e.g. exact, average, weight average
Binding: WeightType (example): The type of substance weight measurement.

.... amount Σ 1..1 Quantity Used to capture quantitative values for a variety of elements
... structure SΣ 0..1 BackboneElement Structural information
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... stereochemistry Σ 0..1 CodeableConcept Stereochemistry type
Binding: Stereochemistry (example): The optical rotation type of a substance.

.... opticalActivity Σ 0..1 CodeableConcept Optical activity type
Binding: OpticalActivity (example): The optical rotation type of a substance.

.... molecularFormula Σ 0..1 string An expression which states the number and type of atoms present in a molecule of a substance
.... molecularFormulaByMoiety Σ 0..1 string Specified per moiety according to the Hill system
.... molecularWeight Σ 0..1 See molecularWeight (SubstanceDefinition) The molecular weight or weight range
.... technique S 0..* CodeableConceptTextOnly Impurity Substance Characterisation Technique
Binding: StructureTechnique (example): The method used to elucidate the structure of the drug substance.


.... sourceDocument Σ 0..* Reference(DocumentReference) Source of information for the structure
.... Slices for representation SΣ 0..* BackboneElement Impurity Structure Graphic | Impurity Structure Data File
Slice: Unordered, Closed by value:type
..... representation:All Slices Content/Rules for all slices
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... type SΣ 1..1 CodeableConcept The kind of structural representation (e.g. full, partial)
Binding: Representation Types (required)
...... representation Σ 0..1 string The structural representation as a text string in a standard format
...... format Σ 0..1 CodeableConcept The format of the representation e.g. InChI, SMILES, MOLFILE (note: not the physical file format)
Binding: SubstanceRepresentationFormat (example): A format of a substance representation.

...... document Σ 0..1 Reference(DocumentReference) An attachment with the structural representation e.g. a structure graphic or AnIML file
..... representation:graphic Σ 0..1 BackboneElement A graphical, displayable depiction of the structure (e.g. an SVG, PNG)
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... type Σ 0..1 CodeableConcept Graphic
Binding: SubstanceRepresentationType (example): A format of a substance representation.


Required Pattern: At least the following
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
........ id 0..1 string Unique id for inter-element referencing
........ extension 0..* Extension Additional content defined by implementations
........ system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
........ version 0..1 string Version of the system - if relevant
........ code 1..1 code Symbol in syntax defined by the system
Fixed Value: C54273
........ display 0..1 string Representation defined by the system
........ userSelected 0..1 boolean If this coding was chosen directly by the user
....... text 0..1 string Plain text representation of the concept
...... representation Σ 0..1 string The structural representation as a text string in a standard format
...... format Σ 0..1 CodeableConcept The format of the representation e.g. InChI, SMILES, MOLFILE (note: not the physical file format)
Binding: SubstanceRepresentationFormat (example): A format of a substance representation.

...... document Σ 1..1 LiteralReference(Graphic Reference) {b} Impurity Structure Graphic
..... representation:structureFile Σ 0..* BackboneElement machine-readable representation -- attached file
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... type Σ 0..1 CodeableConcept Structure File
Binding: SubstanceRepresentationType (example): A format of a substance representation.


Required Pattern: At least the following
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
........ id 0..1 string Unique id for inter-element referencing
........ extension 0..* Extension Additional content defined by implementations
........ system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
........ version 0..1 string Version of the system - if relevant
........ code 1..1 code Symbol in syntax defined by the system
Fixed Value: C103240
........ display 0..1 string Representation defined by the system
........ userSelected 0..1 boolean If this coding was chosen directly by the user
....... text 0..1 string Plain text representation of the concept
...... representation Σ 0..1 string The structural representation as a text string in a standard format
...... format Σ 0..1 CodeableConcept The format of the representation e.g. InChI, SMILES, MOLFILE (note: not the physical file format)
Binding: SubstanceRepresentationFormat (example): A format of a substance representation.

...... document SΣ 1..1 LiteralReference(Structure Data Reference) {b} Impurity Chemical Structure Data (files, e.g. .SDF, .CIF)
..... representation:structureString Σ 0..* BackboneElement machine-readable representation -- plain text
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... type Σ 0..1 CodeableConcept Structure Textual
Binding: SubstanceRepresentationType (example): A format of a substance representation.


Required Pattern: At least the following
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
........ id 0..1 string Unique id for inter-element referencing
........ extension 0..* Extension Additional content defined by implementations
........ system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
........ version 0..1 string Version of the system - if relevant
........ code 1..1 code Symbol in syntax defined by the system
Fixed Value: C45253
........ display 0..1 string Representation defined by the system
........ userSelected 0..1 boolean If this coding was chosen directly by the user
....... text 0..1 string Plain text representation of the concept
...... representation SΣ 1..1 string Impurity Chemical Structure Data (short, plain text representations, e.g. SMILES)
...... format SΣ 1..1 CodeableConcept Drug Substance Impurity Method Type
Binding: Chemical Structure Data File Type Terminology (required)
...... document Σ 0..1 Reference(DocumentReference) An attachment with the structural representation e.g. a structure graphic or AnIML file
... Slices for code SΣ 0..* BackboneElement Codes associated with the substance
Slice: Unordered, Open by value:code.coding.system
.... code:All Slices Content/Rules for all slices
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... code Σ 0..1 CodeableConcept The specific code
..... status Σ 0..1 CodeableConcept Status of the code assignment, for example 'provisional', 'approved'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... statusDate Σ 0..1 dateTime The date at which the code status was changed
..... note Σ 0..* Annotation Any comment can be provided in this field
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... code:unii Σ 0..1 BackboneElement UNII
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... code SΣ 1..1 CodeableConcept The specific code
...... id 0..1 id Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
...... coding SΣ 1..1 Coding Code defined by a terminology system
....... id 0..1 id Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
....... system SΣ 1..1 uri Identity of the terminology system
Required Pattern: http://fdasis.nlm.nih.gov
....... version Σ 0..1 string Version of the system - if relevant
....... code ΣC 0..1 code Symbol in syntax defined by the system
....... display ΣC 0..1 string Representation defined by the system
....... userSelected Σ 0..1 boolean If this coding was chosen directly by the user
...... text Σ 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept Status of the code assignment, for example 'provisional', 'approved'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... statusDate Σ 0..1 dateTime The date at which the code status was changed
..... note Σ 0..* Annotation Any comment can be provided in this field
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... code:uniProt Σ 0..1 BackboneElement UniProt ID
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... code SΣ 1..1 CodeableConcept The specific code
...... id 0..1 id Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
...... coding SΣ 1..1 Coding Code defined by a terminology system
....... id 0..1 id Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
....... system SΣ 1..1 uri Identity of the terminology system
Required Pattern: https://www.uniprot.org
....... version Σ 0..1 string Version of the system - if relevant
....... code ΣC 0..1 code Symbol in syntax defined by the system
....... display ΣC 0..1 string Representation defined by the system
....... userSelected Σ 0..1 boolean If this coding was chosen directly by the user
...... text Σ 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept Status of the code assignment, for example 'provisional', 'approved'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... statusDate Σ 0..1 dateTime The date at which the code status was changed
..... note Σ 0..* Annotation Any comment can be provided in this field
..... source Σ 0..* Reference(DocumentReference) Supporting literature
... Slices for name SΣC 1..* BackboneElement Substance Name
Slice: Unordered, Closed by value:type
cmc-name-preferred: Name.preferred: at most one = true
.... name:All Slices Content/Rules for all slices
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name Σ 1..1 string The actual name
..... type Σ 0..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: Substance Name Type (required)
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred SΣ 0..1 boolean True when the name type is Substance Name
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:sub SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string Generic Name
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.


Required Pattern: At least the following
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C97054
....... display 1..1 string Representation defined by the system
Fixed Value: Generic Name
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:gsrs SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string GSRS Preferred Term
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.


Required Pattern: At least the following
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203355
....... display 1..1 string Representation defined by the system
Fixed Value: GSRS Preferred Term
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:isbt SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string ISBT-128 DIN
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.


Required Pattern: At least the following
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C95517
....... display 1..1 string Representation defined by the system
Fixed Value: ISBT-128 DIN
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred SΣ 0..1 boolean If this is the preferred name for this substance
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:comp SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string Company ID/Code
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: SubstanceNameType (example): The type of a name given to a substance.


Required Pattern: At least the following
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203354
....... display 1..1 string Representation defined by the system
Fixed Value: Company ID/Code
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

..... preferred Σ 0..1 boolean If this is the preferred name for this substance
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language

Additional BindingsPurpose
CommonLanguages Starter Set

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.


..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes


..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.

...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.

...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
... relationship Σ 0..* BackboneElement A link between this substance and another
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... substanceDefinition[x] Σ 0..1 A pointer to another substance, as a resource or a representational code
..... substanceDefinitionReference Reference(SubstanceDefinition)
..... substanceDefinitionCodeableConcept CodeableConcept
.... type Σ 1..1 CodeableConcept For example "salt to parent", "active moiety"
Binding: SubstanceRelationshipType (example): The relationship between two substance types.

.... isDefining Σ 0..1 boolean For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible relationships
.... amount[x] Σ 0..1 A numeric factor for the relationship, e.g. that a substance salt has some percentage of active substance in relation to some other
..... amountQuantity Quantity
..... amountRatio Ratio
..... amountString string
.... ratioHighLimitAmount Σ 0..1 Ratio For use when the numeric has an uncertain range
.... comparator Σ 0..1 CodeableConcept An operator for the amount, for example "average", "approximately", "less than"
Binding: SubstanceAmountType (example): The relationship between two substance types.

.... source Σ 0..* Reference(DocumentReference) Supporting literature
... nucleicAcid Σ 0..1 Reference(SubstanceNucleicAcid) Data items specific to nucleic acids
... polymer Σ 0..1 Reference(SubstancePolymer) Data items specific to polymers
... protein Σ 0..1 Reference(SubstanceProtein) Data items specific to proteins
... sourceMaterial Σ 0..1 BackboneElement Material or taxonomic/anatomical source
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... type Σ 0..1 CodeableConcept Classification of the origin of the raw material. e.g. cat hair is an Animal source type
Binding: SourceMaterialType (example): A classification that provides the origin of the substance raw material.

.... genus Σ 0..1 CodeableConcept The genus of an organism e.g. the Latin epithet of the plant/animal scientific name
Binding: SourceMaterialGenus (example): The genus of an organism, typically referring to the Latin epithet of the genus element of the plant/animal scientific name.

.... species Σ 0..1 CodeableConcept The species of an organism e.g. the Latin epithet of the species of the plant/animal
Binding: SourceMaterialSpecies (example): A species of origin a substance raw material.

.... part Σ 0..1 CodeableConcept An anatomical origin of the source material within an organism
Binding: SourceMaterialPart (example): An anatomical origin of the source material within an organism.

.... countryOfOrigin Σ 0..* CodeableConcept The country or countries where the material is harvested
Binding: CountryValueSet (required): Jurisdiction codes



doco Documentation for this format

Terminology Bindings

PathConformanceValueSet / CodeURI
SubstanceDefinition.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.classificationrequiredPqcmcImpurityClassificationTerminology
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-impurity-classification-terminology
from this IG
SubstanceDefinition.domainexampleMedicinalProductDomain
http://hl7.org/fhir/ValueSet/medicinal-product-domain
from the FHIR Standard
SubstanceDefinition.gradeexampleSubstanceGrade
http://hl7.org/fhir/ValueSet/substance-grade
from the FHIR Standard
SubstanceDefinition.moiety.stereochemistryexampleStereochemistry
http://hl7.org/fhir/ValueSet/substance-stereochemistry
from the FHIR Standard
SubstanceDefinition.moiety.opticalActivityexampleOpticalActivity
http://hl7.org/fhir/ValueSet/substance-optical-activity
from the FHIR Standard
SubstanceDefinition.moiety.measurementTypeexampleSubstanceAmountType
http://hl7.org/fhir/ValueSet/substance-amount-type
from the FHIR Standard
SubstanceDefinition.characterization.techniqueexampleStructureTechnique
http://hl7.org/fhir/ValueSet/substance-structure-technique
from the FHIR Standard
SubstanceDefinition.characterization.formexampleSubstanceForm
http://hl7.org/fhir/ValueSet/substance-form
from the FHIR Standard
SubstanceDefinition.property.typeexampleProductCharacteristic
http://hl7.org/fhir/ValueSet/product-characteristic-codes
from the FHIR Standard
SubstanceDefinition.molecularWeight.methodexampleWeightMethod
http://hl7.org/fhir/ValueSet/substance-weight-method
from the FHIR Standard
SubstanceDefinition.molecularWeight.typeexampleWeightType
http://hl7.org/fhir/ValueSet/substance-weight-type
from the FHIR Standard
SubstanceDefinition.structure.stereochemistryexampleStereochemistry
http://hl7.org/fhir/ValueSet/substance-stereochemistry
from the FHIR Standard
SubstanceDefinition.structure.opticalActivityexampleOpticalActivity
http://hl7.org/fhir/ValueSet/substance-optical-activity
from the FHIR Standard
SubstanceDefinition.structure.techniqueexampleStructureTechnique
http://hl7.org/fhir/ValueSet/substance-structure-technique
from the FHIR Standard
SubstanceDefinition.structure.representation.typerequiredPqcmcRepresentationTypes
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-representation-types
from this IG
SubstanceDefinition.structure.representation.formatexampleSubstanceRepresentationFormat
http://hl7.org/fhir/ValueSet/substance-representation-format
from the FHIR Standard
SubstanceDefinition.structure.representation:graphic.typeexamplePattern: C54273
http://hl7.org/fhir/ValueSet/substance-representation-type
from the FHIR Standard
SubstanceDefinition.structure.representation:graphic.formatexampleSubstanceRepresentationFormat
http://hl7.org/fhir/ValueSet/substance-representation-format
from the FHIR Standard
SubstanceDefinition.structure.representation:structureFile.typeexamplePattern: C103240
http://hl7.org/fhir/ValueSet/substance-representation-type
from the FHIR Standard
SubstanceDefinition.structure.representation:structureFile.formatexampleSubstanceRepresentationFormat
http://hl7.org/fhir/ValueSet/substance-representation-format
from the FHIR Standard
SubstanceDefinition.structure.representation:structureString.typeexamplePattern: C45253
http://hl7.org/fhir/ValueSet/substance-representation-type
from the FHIR Standard
SubstanceDefinition.structure.representation:structureString.formatrequiredPqcmcChemicalStructureDataFileTypeTerminology
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-chemical-structure-datafile-type-terminology
from this IG
SubstanceDefinition.code.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.code:unii.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.code:uniProt.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name.typerequiredPqcmcSubstanceNameType
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-substance-name-type
from this IG
SubstanceDefinition.name.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:sub.typeexamplePattern: C97054("Generic Name")
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:sub.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:sub.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name:sub.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name:sub.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name:sub.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name:sub.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:gsrs.typeexamplePattern: C203355("GSRS Preferred Term")
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:gsrs.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:gsrs.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name:gsrs.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name:gsrs.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name:gsrs.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name:gsrs.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:isbt.typeexamplePattern: C95517("ISBT-128 DIN")
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:isbt.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:isbt.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name:isbt.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name:isbt.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name:isbt.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name:isbt.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:comp.typeexamplePattern: C203354("Company ID/Code")
http://hl7.org/fhir/ValueSet/substance-name-type
from the FHIR Standard
SubstanceDefinition.name:comp.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.name:comp.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
from the FHIR Standard
SubstanceDefinition.name:comp.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
from the FHIR Standard
SubstanceDefinition.name:comp.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
from the FHIR Standard
SubstanceDefinition.name:comp.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
from the FHIR Standard
SubstanceDefinition.name:comp.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
from the FHIR Standard
SubstanceDefinition.relationship.typeexampleSubstanceRelationshipType
http://hl7.org/fhir/ValueSet/substance-relationship-type
from the FHIR Standard
SubstanceDefinition.relationship.comparatorexampleSubstanceAmountType
http://hl7.org/fhir/ValueSet/substance-amount-type
from the FHIR Standard
SubstanceDefinition.sourceMaterial.typeexampleSourceMaterialType
http://hl7.org/fhir/ValueSet/substance-source-material-type
from the FHIR Standard
SubstanceDefinition.sourceMaterial.genusexampleSourceMaterialGenus
http://hl7.org/fhir/ValueSet/substance-source-material-genus
from the FHIR Standard
SubstanceDefinition.sourceMaterial.speciesexampleSourceMaterialSpecies
http://hl7.org/fhir/ValueSet/substance-source-material-species
from the FHIR Standard
SubstanceDefinition.sourceMaterial.partexampleSourceMaterialPart
http://hl7.org/fhir/ValueSet/substance-source-material-part
from the FHIR Standard
SubstanceDefinition.sourceMaterial.countryOfOriginrequiredCountryValueSet
http://hl7.org/fhir/ValueSet/country|5.0.0
from the FHIR Standard

Constraints

IdGradePath(s)DetailsRequirements
att-1errorSubstanceDefinition.characterization.file:AnalysisGraphic, SubstanceDefinition.characterization.file:AnalyticalInstrumentDataIf the Attachment has data, it SHALL have a contentType
: data.empty() or contentType.exists()
cmc-impurity-unii-requirederrorSubstanceDefinitionIf Product Impurity Chemical Structure Data File is not present, then a unii is required
: structure.representation.type.coding.where( system = 'http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl' and code = 'C103240' ).exists().not() implies ( code.where( code.coding.exists(system = 'http://fdasis.nlm.nih.gov') ).exists() )
cmc-name-preferrederrorSubstanceDefinition.nameName.preferred: at most one = true
: select(preferred = true).count() < 2
dom-2errorSubstanceDefinitionIf the resource is contained in another resource, it SHALL NOT contain nested Resources
: contained.contained.empty()
dom-3errorSubstanceDefinitionIf the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource
: contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().ofType(canonical) | %resource.descendants().ofType(uri) | %resource.descendants().ofType(url))) or descendants().where(reference = '#').exists() or descendants().where(ofType(canonical) = '#').exists() or descendants().where(ofType(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4errorSubstanceDefinitionIf a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated
: contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5errorSubstanceDefinitionIf a resource is contained in another resource, it SHALL NOT have a security label
: contained.meta.security.empty()
dom-6best practiceSubstanceDefinitionA resource should have narrative for robust management
: text.`div`.exists()
ele-1error**ALL** elementsAll FHIR elements must have a @value or children
: hasValue() or (children().count() > id.count())
ext-1error**ALL** extensionsMust have either extensions or value[x], not both
: extension.exists() != value.exists()

This structure is derived from SubstanceDefinition

Summary

Mandatory: 2 elements(15 nested mandatory elements)
Must-Support: 37 elements

Structures

This structure refers to these other structures:

Slices

This structure defines the following Slices:

  • The element 1 is sliced based on the value of SubstanceDefinition.characterization.file
  • The element 1 is sliced based on the value of SubstanceDefinition.structure.representation (Closed)
  • The element 1 is sliced based on the value of SubstanceDefinition.code
  • The element 1 is sliced based on the value of SubstanceDefinition.name (Closed)

 

Other representations of profile: CSV, Excel, Schematron