Pharmaceutical Quality - Chemistry, Manufacturing and Controls (PQ-CMC) Submissions to FDA, published by HL7 International / Biomedical Research and Regulation. This guide is not an authorized publication; it is the continuous build for version 1.1.6 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/FHIR-us-pq-cmc-fda/ and changes regularly. See the Directory of published versions

• Content
• Detailed Descriptions
• Examples
• XML
• JSON

Resource Profile: Drug Substance Impurity

Any component of the drug substance that is not the chemical entity for procduct composition.

Usage:

• Use this Resource Profile: CMC eCTD 32P55 Document and CMC eCTD 32S3 Document
• Refer to this Resource Profile: Drug Product Impurities and Drug Substance
• Examples for this Resource Profile: SubstanceDefinition/55f2bbea-1a2d-4240-aef0-bc1a76b39212, SubstanceDefinition/58ae52aa-c81e-415a-8791-e67a3195290d, SubstanceDefinition/7f7c63b0-8ad8-4529-b000-bf4b6c384558, SubstanceDefinition/8202d18a-df68-4cbd-912d-59c7cff5cfa6... Show 2 more, SubstanceDefinition/ac7ac2da-df69-4ed9-b399-4dc40a71b332 and SubstanceDefinition/ffa30c0b-8031-436a-87f1-635b3bbe5989

Formal Views of Profile Content

Description of Profiles, Differentials, Snapshots and how the different presentations work.

• Differential Table
• Key Elements Table
• Snapshot Table
• Statistics/References
• All

This structure is derived from SubstanceDefinition

Name	Flags	Card.	Type	Description & Constraints
SubstanceDefinition	C	0..*	SubstanceDefinition	The detailed description of a substance, typically at a level beyond what is used for prescribing cmc-impurity-unii-required: If Product Impurity Chemical Structure Data File is not present, then a unii is required
meta
profile	S	0..1	canonical(StructureDefinition)	Profiles this resource claims to conform to
identifier	S	0..1	Identifier	optional user designated identifier
classification	S	1..*	CodeableConcept	Impurity Classification Binding: Impurity Classification Terminology (required)
characterization	S	0..*	BackboneElement	General specifications for this substance
technique		0..1	CodeableConcept	The method used to find the characterization e.g. HPLC
text	S	1..1	string	Substance Characterisation Technique
description	S	0..1	markdown	Analysis Narrative Text and Table
Slices for file	S	0..*	Attachment	Impurity Analysis Graphic | Impurity Analytical Instrument Data File Slice: Unordered, Open by profile:$this
file:AnalysisGraphic		0..*	GraphicAttachment	Analysis Graphic
file:AnalyticalInstrumentData		0..*	AnalyticalInstrumentData	Analytical Instrument Data File
structure	S	0..1	BackboneElement	Structural information
technique	S	0..*	CodeableConcept	Impurity Substance Characterisation Technique
text	S	1..1	string	Plain text representation of the concept
Slices for representation	S	0..*	BackboneElement	Impurity Structure Graphic | Impurity Structure Data File Slice: Unordered, Closed by value:type.text
representation:graphic		0..1	BackboneElement	A graphical, displayable depiction of the structure (e.g. an SVG, PNG)
type	S	1..1	CodeableConcept	The kind of structural representation (e.g. full, partial)
text	S	1..1	string	Plain text representation of the concept Required Pattern: Graphics
document		1..1	Reference(Graphic Reference)	Impurity Structure Graphic
representation:structureData		0..*	BackboneElement	machine-readable representation -- may be plain text (e.g. SMILES) or an attached file (e.g. SDF)
type	S	1..1	CodeableConcept	The kind of structural representation (e.g. full, partial)
text	S	1..1	string	Plain text representation of the concept Required Pattern: Structure
representation	S	0..1	string	Impurity Chemical Structure Data (short, plain text representations, e.g. SMILES)
format	S	0..1	CodeableConcept	Drug Substance Impurity Method Type
text	S	0..1	string	Plain text representation of the concept
document	S	0..1	Reference(Structure Data Reference)	Impurity Chemical Structure Data (large files, e.g. SDF, CIF)
Slices for code	S	0..*	BackboneElement	Codes associated with the substance Slice: Unordered, Open by value:code.coding.system
code:unii		0..1	BackboneElement	UNII
code	S	1..1	CodeableConcept	The specific code
coding	S	1..1	Coding	Code defined by a terminology system
system	S	1..1	uri	Identity of the terminology system Required Pattern: http://fdasis.nlm.nih.gov
code:uniProt		0..1	BackboneElement	UniProt ID
code	S	1..1	CodeableConcept	The specific code
coding	S	1..1	Coding	Code defined by a terminology system
system	S	1..1	uri	Identity of the terminology system Required Pattern: https://www.uniprot.org
Slices for name	SC	1..*	BackboneElement	Substance Name Slice: Unordered, Closed by value:type.coding cmc-name-preferred: Name.preferred: at most one = true
name:All Slices				Content/Rules for all slices
preferred	S	0..1	boolean	True when the name type is Substance Name
name:sub	S	0..1	BackboneElement	Names applicable to this substance
name	S	1..1	string	Generic Name
type	S	1..1	CodeableConcept	Name type e.g. 'systematic', 'scientific, 'brand'
coding	S	1..1	Coding	Code defined by a terminology system Required Pattern: At least the following
system		1..1	uri	Identity of the terminology system Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
code		1..1	code	Symbol in syntax defined by the system Fixed Value: C97054
display		1..1	string	Representation defined by the system Fixed Value: Generic Name
preferred	S	0..1	boolean	If this is the preferred name for this substance
name:gsrs	S	0..1	BackboneElement	Names applicable to this substance
name	S	1..1	string	GSRS Preferred Term
type	S	1..1	CodeableConcept	Name type e.g. 'systematic', 'scientific, 'brand'
coding	S	1..1	Coding	Code defined by a terminology system Required Pattern: At least the following
system		1..1	uri	Identity of the terminology system Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
code		1..1	code	Symbol in syntax defined by the system Fixed Value: C203355
display		1..1	string	Representation defined by the system Fixed Value: GSRS Preferred Term
preferred	S	0..1	boolean	If this is the preferred name for this substance
name:isbt	S	0..1	BackboneElement	Names applicable to this substance
name	S	1..1	string	ISBT-128 DIN
type	S	1..1	CodeableConcept	Name type e.g. 'systematic', 'scientific, 'brand'
coding	S	1..1	Coding	Code defined by a terminology system Required Pattern: At least the following
system		1..1	uri	Identity of the terminology system Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
code		1..1	code	Symbol in syntax defined by the system Fixed Value: C95517
display		1..1	string	Representation defined by the system Fixed Value: ISBT-128 DIN
preferred	S	0..1	boolean	If this is the preferred name for this substance
name:comp	S	0..1	BackboneElement	Names applicable to this substance
name	S	1..1	string	Company ID/Code
type	S	1..1	CodeableConcept	Name type e.g. 'systematic', 'scientific, 'brand'
coding		1..1	Coding	Code defined by a terminology system Required Pattern: At least the following
system		1..1	uri	Identity of the terminology system Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
code		1..1	code	Symbol in syntax defined by the system Fixed Value: C203354
display		1..1	string	Representation defined by the system Fixed Value: Company ID/Code
Documentation for this format

Terminology Bindings (Differential)

Path	Conformance	ValueSet	URI
SubstanceDefinition.classification	required	PqcmcImpurityClassificationTerminology http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-impurity-classification-terminology from this IG

Constraints

Id	Grade	Path(s)	Details	Requirements
cmc-impurity-unii-required	error	SubstanceDefinition	If Product Impurity Chemical Structure Data File is not present, then a unii is required : structure.representation.where(type.text = 'Structure' and document.exists()).exists().not() implies ( code.where( code.coding.system = 'http://fdasis.nlm.nih.gov' ).exists() )
cmc-name-preferred	error	SubstanceDefinition.name	Name.preferred: at most one = true : select(preferred = true).count() < 2

Name	Flags	Card.	Type	Description & Constraints
SubstanceDefinition	C	0..*	SubstanceDefinition	The detailed description of a substance, typically at a level beyond what is used for prescribing cmc-impurity-unii-required: If Product Impurity Chemical Structure Data File is not present, then a unii is required
meta	Σ	0..1	Meta	Metadata about the resource
profile	SΣ	0..1	canonical(StructureDefinition)	Profiles this resource claims to conform to
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
contained		0..*	Resource	Contained, inline Resources
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored
identifier	SΣ	0..1	Identifier	optional user designated identifier
classification	SΣ	1..*	CodeableConcept	Impurity Classification Binding: Impurity Classification Terminology (required)
characterization	SΣ	0..*	BackboneElement	General specifications for this substance
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
technique	Σ	0..1	CodeableConcept	The method used to find the characterization e.g. HPLC Binding: StructureTechnique (example): The method used to elucidate the characterization of the drug substance.
text	SΣ	1..1	string	Substance Characterisation Technique
description	SΣ	0..1	markdown	Analysis Narrative Text and Table
Slices for file	SΣ	0..*	Attachment	Impurity Analysis Graphic | Impurity Analytical Instrument Data File Slice: Unordered, Open by profile:$this
file:AnalysisGraphic	C	0..*	GraphicAttachment	Analysis Graphic att-1: If the Attachment has data, it SHALL have a contentType
file:AnalyticalInstrumentData	C	0..*	AnalyticalInstrumentData	Analytical Instrument Data File att-1: If the Attachment has data, it SHALL have a contentType
structure	SΣ	0..1	BackboneElement	Structural information
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
technique	SΣ	0..*	CodeableConcept	Impurity Substance Characterisation Technique Binding: StructureTechnique (example): The method used to elucidate the structure of the drug substance.
text	SΣ	1..1	string	Plain text representation of the concept
Slices for representation	SΣ	0..*	BackboneElement	Impurity Structure Graphic | Impurity Structure Data File Slice: Unordered, Closed by value:type.text
representation:All Slices				Content/Rules for all slices
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
representation:graphic	Σ	0..1	BackboneElement	A graphical, displayable depiction of the structure (e.g. an SVG, PNG)
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
type	SΣ	1..1	CodeableConcept	The kind of structural representation (e.g. full, partial) Binding: SubstanceRepresentationType (example): A format of a substance representation.
text	SΣ	1..1	string	Plain text representation of the concept Required Pattern: Graphics
document	Σ	1..1	Reference(Graphic Reference)	Impurity Structure Graphic
representation:structureData	Σ	0..*	BackboneElement	machine-readable representation -- may be plain text (e.g. SMILES) or an attached file (e.g. SDF)
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
type	SΣ	1..1	CodeableConcept	The kind of structural representation (e.g. full, partial) Binding: SubstanceRepresentationType (example): A format of a substance representation.
text	SΣ	1..1	string	Plain text representation of the concept Required Pattern: Structure
representation	SΣ	0..1	string	Impurity Chemical Structure Data (short, plain text representations, e.g. SMILES)
format	SΣ	0..1	CodeableConcept	Drug Substance Impurity Method Type Binding: SubstanceRepresentationFormat (example): A format of a substance representation.
text	SΣ	0..1	string	Plain text representation of the concept
document	SΣ	0..1	Reference(Structure Data Reference)	Impurity Chemical Structure Data (large files, e.g. SDF, CIF)
Slices for code	SΣ	0..*	BackboneElement	Codes associated with the substance Slice: Unordered, Open by value:code.coding.system
code:All Slices				Content/Rules for all slices
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
code:unii	Σ	0..1	BackboneElement	UNII
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
code	SΣ	1..1	CodeableConcept	The specific code
coding	SΣ	1..1	Coding	Code defined by a terminology system
system	SΣ	1..1	uri	Identity of the terminology system Required Pattern: http://fdasis.nlm.nih.gov
code:uniProt	Σ	0..1	BackboneElement	UniProt ID
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
code	SΣ	1..1	CodeableConcept	The specific code
coding	SΣ	1..1	Coding	Code defined by a terminology system
system	SΣ	1..1	uri	Identity of the terminology system Required Pattern: https://www.uniprot.org
Slices for name	SΣC	1..*	BackboneElement	Substance Name Slice: Unordered, Closed by value:type.coding cmc-name-preferred: Name.preferred: at most one = true
name:All Slices				Content/Rules for all slices
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
name	Σ	1..1	string	The actual name
preferred	SΣ	0..1	boolean	True when the name type is Substance Name
name:sub	SΣ	0..1	BackboneElement	Names applicable to this substance
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
name	SΣ	1..1	string	Generic Name
type	SΣ	1..1	CodeableConcept	Name type e.g. 'systematic', 'scientific, 'brand' Binding: SubstanceNameType (example): The type of a name given to a substance.
coding	SΣ	1..1	Coding	Code defined by a terminology system Required Pattern: At least the following
system		1..1	uri	Identity of the terminology system Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
code		1..1	code	Symbol in syntax defined by the system Fixed Value: C97054
display		1..1	string	Representation defined by the system Fixed Value: Generic Name
preferred	SΣ	0..1	boolean	If this is the preferred name for this substance
name:gsrs	SΣ	0..1	BackboneElement	Names applicable to this substance
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
name	SΣ	1..1	string	GSRS Preferred Term
type	SΣ	1..1	CodeableConcept	Name type e.g. 'systematic', 'scientific, 'brand' Binding: SubstanceNameType (example): The type of a name given to a substance.
coding	SΣ	1..1	Coding	Code defined by a terminology system Required Pattern: At least the following
system		1..1	uri	Identity of the terminology system Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
code		1..1	code	Symbol in syntax defined by the system Fixed Value: C203355
display		1..1	string	Representation defined by the system Fixed Value: GSRS Preferred Term
preferred	SΣ	0..1	boolean	If this is the preferred name for this substance
name:isbt	SΣ	0..1	BackboneElement	Names applicable to this substance
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
name	SΣ	1..1	string	ISBT-128 DIN
type	SΣ	1..1	CodeableConcept	Name type e.g. 'systematic', 'scientific, 'brand' Binding: SubstanceNameType (example): The type of a name given to a substance.
coding	SΣ	1..1	Coding	Code defined by a terminology system Required Pattern: At least the following
system		1..1	uri	Identity of the terminology system Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
code		1..1	code	Symbol in syntax defined by the system Fixed Value: C95517
display		1..1	string	Representation defined by the system Fixed Value: ISBT-128 DIN
preferred	SΣ	0..1	boolean	If this is the preferred name for this substance
name:comp	SΣ	0..1	BackboneElement	Names applicable to this substance
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
name	SΣ	1..1	string	Company ID/Code
type	SΣ	1..1	CodeableConcept	Name type e.g. 'systematic', 'scientific, 'brand' Binding: SubstanceNameType (example): The type of a name given to a substance.
coding	Σ	1..1	Coding	Code defined by a terminology system Required Pattern: At least the following
system		1..1	uri	Identity of the terminology system Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
code		1..1	code	Symbol in syntax defined by the system Fixed Value: C203354
display		1..1	string	Representation defined by the system Fixed Value: Company ID/Code
Documentation for this format

Terminology Bindings

Path	Conformance	ValueSet	URI
SubstanceDefinition.classification	required	PqcmcImpurityClassificationTerminology http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-impurity-classification-terminology from this IG
SubstanceDefinition.characterization.technique	example	StructureTechnique http://hl7.org/fhir/ValueSet/substance-structure-technique from the FHIR Standard
SubstanceDefinition.structure.technique	example	StructureTechnique http://hl7.org/fhir/ValueSet/substance-structure-technique from the FHIR Standard
SubstanceDefinition.structure.representation:graphic.type	example	SubstanceRepresentationType http://hl7.org/fhir/ValueSet/substance-representation-type from the FHIR Standard
SubstanceDefinition.structure.representation:structureData.type	example	SubstanceRepresentationType http://hl7.org/fhir/ValueSet/substance-representation-type from the FHIR Standard
SubstanceDefinition.structure.representation:structureData.format	example	SubstanceRepresentationFormat http://hl7.org/fhir/ValueSet/substance-representation-format from the FHIR Standard
SubstanceDefinition.name:sub.type	example	SubstanceNameType http://hl7.org/fhir/ValueSet/substance-name-type from the FHIR Standard
SubstanceDefinition.name:gsrs.type	example	SubstanceNameType http://hl7.org/fhir/ValueSet/substance-name-type from the FHIR Standard
SubstanceDefinition.name:isbt.type	example	SubstanceNameType http://hl7.org/fhir/ValueSet/substance-name-type from the FHIR Standard
SubstanceDefinition.name:comp.type	example	SubstanceNameType http://hl7.org/fhir/ValueSet/substance-name-type from the FHIR Standard

Constraints

Id	Grade	Path(s)	Details	Requirements
att-1	error	SubstanceDefinition.characterization.file:AnalysisGraphic, SubstanceDefinition.characterization.file:AnalyticalInstrumentData	If the Attachment has data, it SHALL have a contentType : data.empty() or contentType.exists()
cmc-impurity-unii-required	error	SubstanceDefinition	If Product Impurity Chemical Structure Data File is not present, then a unii is required : structure.representation.where(type.text = 'Structure' and document.exists()).exists().not() implies ( code.where( code.coding.system = 'http://fdasis.nlm.nih.gov' ).exists() )
cmc-name-preferred	error	SubstanceDefinition.name	Name.preferred: at most one = true : select(preferred = true).count() < 2
dom-2	error	SubstanceDefinition	If the resource is contained in another resource, it SHALL NOT contain nested Resources : contained.contained.empty()
dom-3	error	SubstanceDefinition	If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource : contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().ofType(canonical) | %resource.descendants().ofType(uri) | %resource.descendants().ofType(url))) or descendants().where(reference = '#').exists() or descendants().where(ofType(canonical) = '#').exists() or descendants().where(ofType(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4	error	SubstanceDefinition	If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated : contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5	error	SubstanceDefinition	If a resource is contained in another resource, it SHALL NOT have a security label : contained.meta.security.empty()
dom-6	best practice	SubstanceDefinition	A resource should have narrative for robust management : text.`div`.exists()
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children : hasValue() or (children().count() > id.count())
ext-1	error	**ALL** extensions	Must have either extensions or value[x], not both : extension.exists() != value.exists()

Name	Flags	Card.	Type	Description & Constraints
SubstanceDefinition	C	0..*	SubstanceDefinition	The detailed description of a substance, typically at a level beyond what is used for prescribing cmc-impurity-unii-required: If Product Impurity Chemical Structure Data File is not present, then a unii is required
id	Σ	0..1	id	Logical id of this artifact
meta	Σ	0..1	Meta	Metadata about the resource
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
versionId	Σ	0..1	id	Version specific identifier
lastUpdated	Σ	0..1	instant	When the resource version last changed
source	Σ	0..1	uri	Identifies where the resource comes from
profile	SΣ	0..1	canonical(StructureDefinition)	Profiles this resource claims to conform to
security	Σ	0..*	Coding	Security Labels applied to this resource Binding: AllSecurityLabels (extensible): Security Labels from the Healthcare Privacy and Security Classification System.
tag	Σ	0..*	Coding	Tags applied to this resource Binding: CommonTags (example): Codes that represent various types of tags, commonly workflow-related; e.g. "Needs review by Dr. Jones".
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
language		0..1	code	Language of the resource content Binding: AllLanguages (required): IETF language tag for a human language Additional Bindings Purpose CommonLanguages Starter Set
text		0..1	Narrative	Text summary of the resource, for human interpretation
contained		0..*	Resource	Contained, inline Resources
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored
identifier	SΣ	0..1	Identifier	optional user designated identifier
version	Σ	0..1	string	A business level version identifier of the substance
status	Σ	0..1	CodeableConcept	Status of substance within the catalogue e.g. active, retired Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
classification	SΣ	1..*	CodeableConcept	Impurity Classification Binding: Impurity Classification Terminology (required)
domain	Σ	0..1	CodeableConcept	If the substance applies to human or veterinary use Binding: MedicinalProductDomain (example): Applicable domain for this product (e.g. human, veterinary).
grade	Σ	0..*	CodeableConcept	The quality standard, established benchmark, to which substance complies (e.g. USP/NF, BP) Binding: SubstanceGrade (example): The quality standard, established benchmark, to which a substance complies
description	Σ	0..1	markdown	Textual description of the substance
informationSource	Σ	0..*	Reference(Citation)	Supporting literature
note	Σ	0..*	Annotation	Textual comment about the substance's catalogue or registry record
manufacturer	Σ	0..*	Reference(Organization)	The entity that creates, makes, produces or fabricates the substance
supplier	Σ	0..*	Reference(Organization)	An entity that is the source for the substance. It may be different from the manufacturer
moiety	Σ	0..*	BackboneElement	Moiety, for structural modifications
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
role	Σ	0..1	CodeableConcept	Role that the moiety is playing
identifier	Σ	0..1	Identifier	Identifier by which this moiety substance is known
name	Σ	0..1	string	Textual name for this moiety substance
stereochemistry	Σ	0..1	CodeableConcept	Stereochemistry type Binding: Stereochemistry (example): The optical rotation type of a substance.
opticalActivity	Σ	0..1	CodeableConcept	Optical activity type Binding: OpticalActivity (example): The optical rotation type of a substance.
molecularFormula	Σ	0..1	string	Molecular formula for this moiety (e.g. with the Hill system)
amount[x]	Σ	0..1		Quantitative value for this moiety
amountQuantity			Quantity
amountString			string
measurementType	Σ	0..1	CodeableConcept	The measurement type of the quantitative value Binding: SubstanceAmountType (example): The relationship between two substance types.
characterization	SΣ	0..*	BackboneElement	General specifications for this substance
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
technique	Σ	0..1	CodeableConcept	The method used to find the characterization e.g. HPLC Binding: StructureTechnique (example): The method used to elucidate the characterization of the drug substance.
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	Σ	0..*	Coding	Code defined by a terminology system
text	SΣ	1..1	string	Substance Characterisation Technique
form	Σ	0..1	CodeableConcept	Describes the nature of the chemical entity and explains, for instance, whether this is a base or a salt form Binding: SubstanceForm (example)
description	SΣ	0..1	markdown	Analysis Narrative Text and Table
Slices for file	SΣ	0..*	Attachment	Impurity Analysis Graphic | Impurity Analytical Instrument Data File Slice: Unordered, Open by profile:$this
file:AnalysisGraphic	C	0..*	GraphicAttachment	Analysis Graphic att-1: If the Attachment has data, it SHALL have a contentType
file:AnalyticalInstrumentData	C	0..*	AnalyticalInstrumentData	Analytical Instrument Data File att-1: If the Attachment has data, it SHALL have a contentType
property	Σ	0..*	BackboneElement	General specifications for this substance
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
type	Σ	1..1	CodeableConcept	A code expressing the type of property Binding: ProductCharacteristic (example): This value set includes all observable entity codes from SNOMED CT - provided as an exemplar value set.
value[x]	Σ	0..1		A value for the property
valueCodeableConcept			CodeableConcept
valueQuantity			Quantity
valueDate			date
valueBoolean			boolean
valueAttachment			Attachment
referenceInformation	Σ	0..1	Reference(SubstanceReferenceInformation)	General information detailing this substance
molecularWeight	Σ	0..*	BackboneElement	The average mass of a molecule of a compound
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
method	Σ	0..1	CodeableConcept	The method by which the weight was determined Binding: WeightMethod (example): The method by which the substance weight was measured.
type	Σ	0..1	CodeableConcept	Type of molecular weight e.g. exact, average, weight average Binding: WeightType (example): The type of substance weight measurement.
amount	Σ	1..1	Quantity	Used to capture quantitative values for a variety of elements
structure	SΣ	0..1	BackboneElement	Structural information
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
stereochemistry	Σ	0..1	CodeableConcept	Stereochemistry type Binding: Stereochemistry (example): The optical rotation type of a substance.
opticalActivity	Σ	0..1	CodeableConcept	Optical activity type Binding: OpticalActivity (example): The optical rotation type of a substance.
molecularFormula	Σ	0..1	string	An expression which states the number and type of atoms present in a molecule of a substance
molecularFormulaByMoiety	Σ	0..1	string	Specified per moiety according to the Hill system
molecularWeight	Σ	0..1	See molecularWeight (SubstanceDefinition)	The molecular weight or weight range
technique	SΣ	0..*	CodeableConcept	Impurity Substance Characterisation Technique Binding: StructureTechnique (example): The method used to elucidate the structure of the drug substance.
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	Σ	0..*	Coding	Code defined by a terminology system
text	SΣ	1..1	string	Plain text representation of the concept
sourceDocument	Σ	0..*	Reference(DocumentReference)	Source of information for the structure
Slices for representation	SΣ	0..*	BackboneElement	Impurity Structure Graphic | Impurity Structure Data File Slice: Unordered, Closed by value:type.text
representation:All Slices				Content/Rules for all slices
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
type	Σ	0..1	CodeableConcept	The kind of structural representation (e.g. full, partial) Binding: SubstanceRepresentationType (example): A format of a substance representation.
representation	Σ	0..1	string	The structural representation as a text string in a standard format
format	Σ	0..1	CodeableConcept	The format of the representation e.g. InChI, SMILES, MOLFILE (note: not the physical file format) Binding: SubstanceRepresentationFormat (example): A format of a substance representation.
document	Σ	0..1	Reference(DocumentReference)	An attachment with the structural representation e.g. a structure graphic or AnIML file
representation:graphic	Σ	0..1	BackboneElement	A graphical, displayable depiction of the structure (e.g. an SVG, PNG)
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
type	SΣ	1..1	CodeableConcept	The kind of structural representation (e.g. full, partial) Binding: SubstanceRepresentationType (example): A format of a substance representation.
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	Σ	0..*	Coding	Code defined by a terminology system
text	SΣ	1..1	string	Plain text representation of the concept Required Pattern: Graphics
representation	Σ	0..1	string	The structural representation as a text string in a standard format
format	Σ	0..1	CodeableConcept	The format of the representation e.g. InChI, SMILES, MOLFILE (note: not the physical file format) Binding: SubstanceRepresentationFormat (example): A format of a substance representation.
document	Σ	1..1	Reference(Graphic Reference)	Impurity Structure Graphic
representation:structureData	Σ	0..*	BackboneElement	machine-readable representation -- may be plain text (e.g. SMILES) or an attached file (e.g. SDF)
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
type	SΣ	1..1	CodeableConcept	The kind of structural representation (e.g. full, partial) Binding: SubstanceRepresentationType (example): A format of a substance representation.
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	Σ	0..*	Coding	Code defined by a terminology system
text	SΣ	1..1	string	Plain text representation of the concept Required Pattern: Structure
representation	SΣ	0..1	string	Impurity Chemical Structure Data (short, plain text representations, e.g. SMILES)
format	SΣ	0..1	CodeableConcept	Drug Substance Impurity Method Type Binding: SubstanceRepresentationFormat (example): A format of a substance representation.
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	Σ	0..*	Coding	Code defined by a terminology system
text	SΣ	0..1	string	Plain text representation of the concept
document	SΣ	0..1	Reference(Structure Data Reference)	Impurity Chemical Structure Data (large files, e.g. SDF, CIF)
Slices for code	SΣ	0..*	BackboneElement	Codes associated with the substance Slice: Unordered, Open by value:code.coding.system
code:All Slices				Content/Rules for all slices
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
code	Σ	0..1	CodeableConcept	The specific code
status	Σ	0..1	CodeableConcept	Status of the code assignment, for example 'provisional', 'approved' Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
statusDate	Σ	0..1	dateTime	The date at which the code status was changed
note	Σ	0..*	Annotation	Any comment can be provided in this field
source	Σ	0..*	Reference(DocumentReference)	Supporting literature
code:unii	Σ	0..1	BackboneElement	UNII
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
code	SΣ	1..1	CodeableConcept	The specific code
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	SΣ	1..1	Coding	Code defined by a terminology system
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
system	SΣ	1..1	uri	Identity of the terminology system Required Pattern: http://fdasis.nlm.nih.gov
version	Σ	0..1	string	Version of the system - if relevant
code	ΣC	0..1	code	Symbol in syntax defined by the system
display	ΣC	0..1	string	Representation defined by the system
userSelected	Σ	0..1	boolean	If this coding was chosen directly by the user
text	Σ	0..1	string	Plain text representation of the concept
status	Σ	0..1	CodeableConcept	Status of the code assignment, for example 'provisional', 'approved' Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
statusDate	Σ	0..1	dateTime	The date at which the code status was changed
note	Σ	0..*	Annotation	Any comment can be provided in this field
source	Σ	0..*	Reference(DocumentReference)	Supporting literature
code:uniProt	Σ	0..1	BackboneElement	UniProt ID
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
code	SΣ	1..1	CodeableConcept	The specific code
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	SΣ	1..1	Coding	Code defined by a terminology system
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
system	SΣ	1..1	uri	Identity of the terminology system Required Pattern: https://www.uniprot.org
version	Σ	0..1	string	Version of the system - if relevant
code	ΣC	0..1	code	Symbol in syntax defined by the system
display	ΣC	0..1	string	Representation defined by the system
userSelected	Σ	0..1	boolean	If this coding was chosen directly by the user
text	Σ	0..1	string	Plain text representation of the concept
status	Σ	0..1	CodeableConcept	Status of the code assignment, for example 'provisional', 'approved' Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
statusDate	Σ	0..1	dateTime	The date at which the code status was changed
note	Σ	0..*	Annotation	Any comment can be provided in this field
source	Σ	0..*	Reference(DocumentReference)	Supporting literature
Slices for name	SΣC	1..*	BackboneElement	Substance Name Slice: Unordered, Closed by value:type.coding cmc-name-preferred: Name.preferred: at most one = true
name:All Slices				Content/Rules for all slices
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
name	Σ	1..1	string	The actual name
type	Σ	0..1	CodeableConcept	Name type e.g. 'systematic', 'scientific, 'brand' Binding: SubstanceNameType (example): The type of a name given to a substance.
status	Σ	0..1	CodeableConcept	The status of the name e.g. 'current', 'proposed' Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
preferred	SΣ	0..1	boolean	True when the name type is Substance Name
language	Σ	0..*	CodeableConcept	Human language that the name is written in Binding: AllLanguages (required): IETF language tag for a human language Additional Bindings Purpose CommonLanguages Starter Set
domain	Σ	0..*	CodeableConcept	The use context of this name e.g. as an active ingredient or as a food colour additive Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.
jurisdiction	Σ	0..*	CodeableConcept	The jurisdiction where this name applies Binding: JurisdictionValueSet (example): Jurisdiction codes
synonym	Σ	0..*	See name (SubstanceDefinition)	A synonym of this particular name, by which the substance is also known
translation	Σ	0..*	See name (SubstanceDefinition)	A translation for this name into another human language
official	Σ	0..*	BackboneElement	Details of the official nature of this name
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
authority	Σ	0..1	CodeableConcept	Which authority uses this official name Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.
status	Σ	0..1	CodeableConcept	The status of the official name, for example 'draft', 'active' Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
date	Σ	0..1	dateTime	Date of official name change
source	Σ	0..*	Reference(DocumentReference)	Supporting literature
name:sub	SΣ	0..1	BackboneElement	Names applicable to this substance
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
name	SΣ	1..1	string	Generic Name
type	SΣ	1..1	CodeableConcept	Name type e.g. 'systematic', 'scientific, 'brand' Binding: SubstanceNameType (example): The type of a name given to a substance.
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	SΣ	1..1	Coding	Code defined by a terminology system Required Pattern: At least the following
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
system		1..1	uri	Identity of the terminology system Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
version		0..1	string	Version of the system - if relevant
code		1..1	code	Symbol in syntax defined by the system Fixed Value: C97054
display		1..1	string	Representation defined by the system Fixed Value: Generic Name
userSelected		0..1	boolean	If this coding was chosen directly by the user
text	Σ	0..1	string	Plain text representation of the concept
status	Σ	0..1	CodeableConcept	The status of the name e.g. 'current', 'proposed' Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
preferred	SΣ	0..1	boolean	If this is the preferred name for this substance
language	Σ	0..*	CodeableConcept	Human language that the name is written in Binding: AllLanguages (required): IETF language tag for a human language Additional Bindings Purpose CommonLanguages Starter Set
domain	Σ	0..*	CodeableConcept	The use context of this name e.g. as an active ingredient or as a food colour additive Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.
jurisdiction	Σ	0..*	CodeableConcept	The jurisdiction where this name applies Binding: JurisdictionValueSet (example): Jurisdiction codes
synonym	Σ	0..*	See name (SubstanceDefinition)	A synonym of this particular name, by which the substance is also known
translation	Σ	0..*	See name (SubstanceDefinition)	A translation for this name into another human language
official	Σ	0..*	BackboneElement	Details of the official nature of this name
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
authority	Σ	0..1	CodeableConcept	Which authority uses this official name Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.
status	Σ	0..1	CodeableConcept	The status of the official name, for example 'draft', 'active' Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
date	Σ	0..1	dateTime	Date of official name change
source	Σ	0..*	Reference(DocumentReference)	Supporting literature
name:gsrs	SΣ	0..1	BackboneElement	Names applicable to this substance
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
name	SΣ	1..1	string	GSRS Preferred Term
type	SΣ	1..1	CodeableConcept	Name type e.g. 'systematic', 'scientific, 'brand' Binding: SubstanceNameType (example): The type of a name given to a substance.
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	SΣ	1..1	Coding	Code defined by a terminology system Required Pattern: At least the following
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
system		1..1	uri	Identity of the terminology system Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
version		0..1	string	Version of the system - if relevant
code		1..1	code	Symbol in syntax defined by the system Fixed Value: C203355
display		1..1	string	Representation defined by the system Fixed Value: GSRS Preferred Term
userSelected		0..1	boolean	If this coding was chosen directly by the user
text	Σ	0..1	string	Plain text representation of the concept
status	Σ	0..1	CodeableConcept	The status of the name e.g. 'current', 'proposed' Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
preferred	SΣ	0..1	boolean	If this is the preferred name for this substance
language	Σ	0..*	CodeableConcept	Human language that the name is written in Binding: AllLanguages (required): IETF language tag for a human language Additional Bindings Purpose CommonLanguages Starter Set
domain	Σ	0..*	CodeableConcept	The use context of this name e.g. as an active ingredient or as a food colour additive Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.
jurisdiction	Σ	0..*	CodeableConcept	The jurisdiction where this name applies Binding: JurisdictionValueSet (example): Jurisdiction codes
synonym	Σ	0..*	See name (SubstanceDefinition)	A synonym of this particular name, by which the substance is also known
translation	Σ	0..*	See name (SubstanceDefinition)	A translation for this name into another human language
official	Σ	0..*	BackboneElement	Details of the official nature of this name
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
authority	Σ	0..1	CodeableConcept	Which authority uses this official name Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.
status	Σ	0..1	CodeableConcept	The status of the official name, for example 'draft', 'active' Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
date	Σ	0..1	dateTime	Date of official name change
source	Σ	0..*	Reference(DocumentReference)	Supporting literature
name:isbt	SΣ	0..1	BackboneElement	Names applicable to this substance
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
name	SΣ	1..1	string	ISBT-128 DIN
type	SΣ	1..1	CodeableConcept	Name type e.g. 'systematic', 'scientific, 'brand' Binding: SubstanceNameType (example): The type of a name given to a substance.
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	SΣ	1..1	Coding	Code defined by a terminology system Required Pattern: At least the following
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
system		1..1	uri	Identity of the terminology system Fixed Value: http://hl7.org/fhir/us/pq-cmc-fda/CodeSystem/cmc-ncit-dummy
version		0..1	string	Version of the system - if relevant
code		1..1	code	Symbol in syntax defined by the system Fixed Value: C95517
display		1..1	string	Representation defined by the system Fixed Value: ISBT-128 DIN
userSelected		0..1	boolean	If this coding was chosen directly by the user
text	Σ	0..1	string	Plain text representation of the concept
status	Σ	0..1	CodeableConcept	The status of the name e.g. 'current', 'proposed' Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
preferred	SΣ	0..1	boolean	If this is the preferred name for this substance
language	Σ	0..*	CodeableConcept	Human language that the name is written in Binding: AllLanguages (required): IETF language tag for a human language Additional Bindings Purpose CommonLanguages Starter Set
domain	Σ	0..*	CodeableConcept	The use context of this name e.g. as an active ingredient or as a food colour additive Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.
jurisdiction	Σ	0..*	CodeableConcept	The jurisdiction where this name applies Binding: JurisdictionValueSet (example): Jurisdiction codes
synonym	Σ	0..*	See name (SubstanceDefinition)	A synonym of this particular name, by which the substance is also known
translation	Σ	0..*	See name (SubstanceDefinition)	A translation for this name into another human language
official	Σ	0..*	BackboneElement	Details of the official nature of this name
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
authority	Σ	0..1	CodeableConcept	Which authority uses this official name Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.
status	Σ	0..1	CodeableConcept	The status of the official name, for example 'draft', 'active' Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
date	Σ	0..1	dateTime	Date of official name change
source	Σ	0..*	Reference(DocumentReference)	Supporting literature
name:comp	SΣ	0..1	BackboneElement	Names applicable to this substance
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
name	SΣ	1..1	string	Company ID/Code
type	SΣ	1..1	CodeableConcept	Name type e.g. 'systematic', 'scientific, 'brand' Binding: SubstanceNameType (example): The type of a name given to a substance.
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