PanCareSurPass Project HL7 FHIR Implementation Guide
1.0.0 - release 150

PanCareSurPass Project HL7 FHIR Implementation Guide, published by PanCareSurPass Project. This guide is not an authorized publication; it is the continuous build for version 1.0.0 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/hl7-eu/pcsp/ and changes regularly. See the Directory of published versions

ValueSet: Risk Factors

Official URL: http://hl7.eu/fhir/ig/pcsp/ValueSet/vs-riskfactor-eu-pcsp Version: 1.0.0
Active as of 2026-01-16 Computable Name: RiskFactor

Risk Factors used by the PCSP algorithm

References

Logical Definition (CLD)

 

Expansion

Expansion performed internally based on codesystem Risk Factors v1.0.0 (CodeSystem)

This value set contains 112 concepts

SystemCodeDisplay (en)DefinitionJSONXML
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  1.1RT to a vol exposing the thyroid glandRT to a vol exposing the thyroid gland
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  1.2TBITBI
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  1.3MIBG therapy (I-131 MIBG therapy)MIBG therapy (I-131 MIBG therapy)
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  2.1RT >= 10 Gy to a vol exposing the breastsRT >= 10 Gy to a vol exposing the breasts
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  2.2OR upper abdominal field radiation that can extend above the diaphragm likely exposing breast tissue at a young ageOR upper abdominal field radiation that can extend above the diaphragm likely exposing breast tissue at a young age
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  3.1RT >= 35 Gy to a vol exposing the heartRT >= 35 Gy to a vol exposing the heart
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  3.2Anthracyclines (doxorubicin isotoxic equivalents)>= 250 mg/m2Anthracyclines (doxorubicin isotoxic equivalents)>= 250 mg/m2
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  3.3RT >= 15 Gy to a vol exposing the heart AND Anthracyclines (doxorubicin isotoxic equivalents)>= 100 mg/m2RT >= 15 Gy to a vol exposing the heart AND Anthracyclines (doxorubicin isotoxic equivalents)>= 100 mg/m2
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  4.1Alkylating agentsAlkylating agents
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  4.2RT to a vol exposing the testesRT to a vol exposing the testes
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  4.3Including TBIIncluding TBI
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  5.1RT >=12 Gy to a vol exposing the testiclesRT >=12 Gy to a vol exposing the testicles
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  6.3Surgery to the spinal cord, sympathetic nerves or pelvisSurgery to the spinal cord, sympathetic nerves or pelvis
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  6.4HypogonadalHypogonadal
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  7.2RT to a vol exposing the ovariesRT to a vol exposing the ovaries
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  8.1RT >= 30 Gy to a vol exposing the head or the brainRT >= 30 Gy to a vol exposing the head or the brain
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  8.2Cisplatin (with or without carboplatin > 1500 mg/m2)Cisplatin (with or without carboplatin > 1500 mg/m2)
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  9.1RT to a vol exposing the pancreasRT to a vol exposing the pancreas
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  10.2HSCTHSCT
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  11.1RT to a volume exposing the hypothalamus or pituatary glandRT to a volume exposing the hypothalamus or pituatary gland
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  11.3Hypothalamic or pituitary tumourHypothalamic or pituitary tumour
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  11.4Neurosurgery of the hypothalamus or pituitary glandNeurosurgery of the hypothalamus or pituitary gland
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  12.1RT to a vol exposing the kidneys, heart and associated large vesselsRT to a vol exposing the kidneys, heart and associated large vessels
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  12.3NephrectomyNephrectomy
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  12.4IfosfamideIfosfamide
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  12.5Platinium based chemotherapyPlatinium based chemotherapy
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  12.6NitrosureasNitrosureas
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  12.7Immunosuppressives treatment and prolonged steroids as anticancer treatment (at least 4 weeks, continuously)Immunosuppressives treatment and prolonged steroids as anticancer treatment (at least 4 weeks, continuously)
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  13.1Cranial and/or spinal RTCranial and/or spinal RT
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  13.3MethotrexateMethotrexate
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  13.4Gonadal failureGonadal failure
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  13.5Growth hormone deficiencyGrowth hormone deficiency
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  13.6Prolonged (at least 4 weeks, continuously) corticosteroids as anti-cancer treatmentProlonged (at least 4 weeks, continuously) corticosteroids as anti-cancer treatment
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  13.7HSCT, especially with an history of GVHDHSCT, especially with an history of GVHD
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  14.3High dose RTHigh dose RT
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  15.1Radiotherapy to a vol exposing the HP region >= 30 GyRadiotherapy to a vol exposing the HP region >= 30 Gy
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  15.2Surgery near or within the HP regionSurgery near or within the HP region
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  15.3CNS tumours near or within the HP regionCNS tumours near or within the HP region
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  16.1Radiotherapy to a vol exposing the HP region< 30 GyRadiotherapy to a vol exposing the HP region< 30 Gy
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  16.2Hydrocephalus or cerebrospinal fluid shunt(Risk factor for GHD)Hydrocephalus or cerebrospinal fluid shunt(Risk factor for GHD)
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  17.1Radiotherapy to a vol exposing the HP regionRadiotherapy to a vol exposing the HP region
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  17.5hydrocephalus or cerebrospinal fluid shunthydrocephalus or cerebrospinal fluid shunt
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  19.3Radioiodine therapy (I-131 ablation therapy)Radioiodine therapy (I-131 ablation therapy)
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  19.5Allogenic HSCTAllogenic HSCT
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  19.6Total thyroidectomyTotal thyroidectomy
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  20.1RT to a vol exposing the head, brain or neckRT to a vol exposing the head, brain or neck
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  21.1History of a central nervous system tumorHistory of a central nervous system tumor
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  21.2RT to a vol exposing the brain ANY DOSERT to a vol exposing the brain ANY DOSE
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  21.4Brain surgeryBrain surgery
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  21.5High dose cytarabine IV (intravenous)High dose cytarabine IV (intravenous)
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  21.6High dose MTX IVHigh dose MTX IV
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  21.7Any Chemotherapy IT (intrathecal)Any Chemotherapy IT (intrathecal)
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  22.1Vinca-AlkaloidsVinca-Alkaloids
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  22.2Cisplatin or carboplatinCisplatin or carboplatin
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  23.1RT to a vol exposing the lensRT to a vol exposing the lens
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  24.1RT to a vol exposing the eye and orbitRT to a vol exposing the eye and orbit
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  25.1RT to a vol exposing the craniofacial area, especially after high doses and at a young ageRT to a vol exposing the craniofacial area, especially after high doses and at a young age
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  25.3Surgery to the face, especially at a young ageSurgery to the face, especially at a young age
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  26.1Surgery of the spineSurgery of the spine
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  26.2Surgery of the chest (Does not include CVC pose)Surgery of the chest (Does not include CVC pose)
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  26.3RT to a vol exposing the spineRT to a vol exposing the spine
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  26.4Spinal or paraspinal malignanciesSpinal or paraspinal malignancies
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  27.1CyclophosphamideCyclophosphamide
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  27.3RT to a vol exposing the bladderRT to a vol exposing the bladder
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  27.5CystectomyCystectomy
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  27.6HysterectomyHysterectomy
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  27.7Pelvic surgeryPelvic surgery
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  27.8Spinal cord surgerySpinal cord surgery
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  28.1RT to a vol exposing the uterus only femaleRT to a vol exposing the uterus only female
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  29.1RT to a vol exposing the oral cavity or salivary glandsRT to a vol exposing the oral cavity or salivary glands
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  29.4ChemotherapyChemotherapy
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  30.1RT to a vol exposing the gastro-intestinal tractRT to a vol exposing the gastro-intestinal tract
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  30.3Oesophageal surgeryOesophageal surgery
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  30.4Abdominal surgeryAbdominal surgery
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  30.5With a history of chronic GVHDWith a history of chronic GVHD
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  31.1Anthracyclines (doxorubicin isotoxic equivalents) <100 mg/m2Anthracyclines (doxorubicin isotoxic equivalents) <100 mg/m2
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  32.1RT to a vol exposing the lungsRT to a vol exposing the lungs
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  32.3BleomycinBleomycin
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  32.4BusulfanBusulfan
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  32.5BCNU CarmustineBCNU Carmustine
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  32.6CCNU LomustineCCNU Lomustine
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  32.7Thoracic surgeryThoracic surgery
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  33.1Cisplatin Any doseCisplatin Any dose
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  33.2Ifosfamide Any doseIfosfamide Any dose
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  33.3Carboplatin Any doseCarboplatin Any dose
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  34.1RT to a volume exposing the liverRT to a volume exposing the liver
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  34.10Chronic GVHDChronic GVHD
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  34.11Liver surgeryLiver surgery
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  34.3HSCT (irrespective of GVHD)HSCT (irrespective of GVHD)
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  34.5Mercaptopurine ThioguanineMercaptopurine Thioguanine
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  34.6DactinomycinDactinomycin
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  34.8Chronic viral hepatitisChronic viral hepatitis
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  34.9Sinusoidal obstruction syndromeSinusoidal obstruction syndrome
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  35.1HSCT (irrespective of GVHD)HSCT (irrespective of GVHD)
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  35.2Multiple red blood cell transfusionsMultiple red blood cell transfusions
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  36.1SplenectomySplenectomy
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  36.2RT >= 10 Gy to a vol exposing the spleenRT >= 10 Gy to a vol exposing the spleen
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  36.3Allogenic HSCT (with or without TBI)Allogenic HSCT (with or without TBI)
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  36.4Autologus HSCT conditioned with TBIAutologus HSCT conditioned with TBI
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  37.1Hereditary cancer sdHereditary cancer sd
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  38.1Any RT including TBI (predominantly in the RT field)Any RT including TBI (predominantly in the RT field)
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  38.2HSCT Especially with a history of skin GvHDHSCT Especially with a history of skin GvHD
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  39.1RT to a vol exposing the colon and rectumRT to a vol exposing the colon and rectum
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  40.1RT to a vol exposing the oral cavityRT to a vol exposing the oral cavity
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  41.2Anthracyclines and/or MitoxantroneAnthracyclines and/or Mitoxantrone
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  41.3Epipodophyllotoxins or autologousEpipodophyllotoxins or autologous
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  41.4Autologous haematopoietic stem cell transplantAutologous haematopoietic stem cell transplant
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  42.1Ciclofosfamide, Ifosfamide (particularly if they have a history of severe hemorrhagic cystitis)Ciclofosfamide, Ifosfamide (particularly if they have a history of severe hemorrhagic cystitis)
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  45.1RT to a vol exposing the head or brainRT to a vol exposing the head or brain
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  46.1RT between 15 and 35 Gy to a vol exposing the heartRT between 15 and 35 Gy to a vol exposing the heart
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  46.2Anthracyclines (doxorubicin isotoxic equivalents) between 100 and 250 mg/m2Anthracyclines (doxorubicin isotoxic equivalents) between 100 and 250 mg/m2
http://hl7.eu/fhir/ig/pcsp/CodeSystem/cs-riskfactor-eu-pcsp  47.1RT to a vol exposing the kidney or urinary tractRT to a vol exposing the kidney or urinary tract

Explanation of the columns that may appear on this page:

Level A few code lists that FHIR defines are hierarchical - each code is assigned a level. In this scheme, some codes are under other codes, and imply that the code they are under also applies
System The source of the definition of the code (when the value set draws in codes defined elsewhere)
Code The code (used as the code in the resource instance)
Display The display (used in the display element of a Coding). If there is no display, implementers should not simply display the code, but map the concept into their application
Definition An explanation of the meaning of the concept
Comments Additional notes about how to use the code