IDEA4RC FHIR Implementation Guide, published by IDEA4RC Project. This guide is not an authorized publication; it is the continuous build for version 0.1.0 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/hl7-eu/idea4rc/ and changes regularly. See the Directory of published versions

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Logical Model: SystemicTreatmentI4rc - XML Profile

XML representation of the SystemicTreatment logical model.

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<StructureDefinition xmlns="http://hl7.org/fhir">
  <id value="SystemicTreatment"/>
  <text>
    <status value="extensions"/>
    <div xmlns="http://www.w3.org/1999/xhtml"><p class="res-header-id"><b>Generated Narrative: StructureDefinition SystemicTreatment</b></p><a name="SystemicTreatment"> </a><a name="hcSystemicTreatment"> </a><a name="SystemicTreatment-en-US"> </a><table border="0" cellpadding="0" cellspacing="0" style="border: 0px #F0F0F0 solid; font-size: 11px; font-family: verdana; vertical-align: top;"><tr style="border: 1px #F0F0F0 solid; font-size: 11px; font-family: verdana; vertical-align: top"><th style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views" title="The logical name of the element">Name</a></th><th style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views" title="Information about the use of the element">Flags</a></th><th style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views" title="Minimum and Maximum # of times the element can appear in the instance">Card.</a></th><th style="width: 100px" class="hierarchy"><a href="https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views" title="Reference to the type of the element">Type</a></th><th style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views" title="Additional information about the element">Description &amp; Constraints</a><span style="float: right"><a href="https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views" title="Legend for this format"><img src="data:image/png;base64,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" alt="doco" style="background-color: inherit"/></a></span></th></tr><tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck1.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_element.gif" alt="." style="background-color: white; background-color: inherit" title="Element" class="hierarchy"/> <a href="StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment" title="Systemic Treatment">SystemicTreatment</a><a name="SystemicTreatment"> </a></td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><span style="opacity: 0.5">0</span><span style="opacity: 0.5">..</span><span style="opacity: 0.5">*</span></td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://build.fhir.org/types.html#Base">Base</a></td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Systemic Treatment<br/><span style="font-weight:bold">Instances of this logical model are not marked to be the target of a Reference</span></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_resource.png" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Resource" class="hierarchy"/> <a href="StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.episodeEventReference" title="EpisodeEvent element containing the data regarding the patient's cancer">episodeEventReference</a><a name="SystemicTreatment.episodeEventReference"> </a></td><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><span style="padding-left: 3px; padding-right: 3px; color: white; background-color: red" title="This element has obligations">O</span></td><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">1..1</td><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="StructureDefinition-EpisodeEvent.html">EpisodeEvent</a></td><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Episode Event reference<table class="grid"><tr><td style="font-size: 11px"><b>Obligations</b></td><td style="font-size: 11px"><b>Actor</b></td></tr><tr><td style="font-size: 11px"><b>SHALL</b>:<span title="obligation: handle">handle</span></td><td style="font-size: 11px; opacity: 0.5;"><a href="ActorDefinition-actor-headneck-i4rc.html"/></td></tr><tr><td style="font-size: 11px"><b>SHALL</b>:<span title="obligation: handle">handle</span></td><td style="font-size: 11px; opacity: 0.5;"><a href="ActorDefinition-actor-sarcoma-i4rc.html"/></td></tr></table></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: white; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.typeOfSystemicTreatment" title="Select the type of Systemic treatment administered. It is possible to directly select the single treatment as appropriate.">typeOfSystemicTreatment</a><a name="SystemicTreatment.typeOfSystemicTreatment"> </a></td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><span style="padding-left: 3px; padding-right: 3px; color: white; background-color: red" title="This element has obligations">O</span></td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">1..1</td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R4/datatypes.html#CodeableConcept">CodeableConcept</a></td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">type of Systemic treatment<table class="grid"><tr><td style="font-size: 11px"><b>Obligations</b></td><td style="font-size: 11px"><b>Actor</b></td></tr><tr><td style="font-size: 11px"><b>SHALL</b>:<span title="obligation: handle">handle</span></td><td style="font-size: 11px; opacity: 0.5;"><a href="ActorDefinition-actor-headneck-i4rc.html"/></td></tr><tr><td style="font-size: 11px"><b>SHALL</b>:<span title="obligation: handle">handle</span></td><td style="font-size: 11px; opacity: 0.5;"><a href="ActorDefinition-actor-sarcoma-i4rc.html"/></td></tr></table></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.intent" title="Clarifies the reasons why Other therapy is administered
? Curative chemotherapy is chemotherapy administered with the goal of achieving a complete remission and preventing the recurrence of cancer. 
? Palliative chemotherapy refers to any chemotherapy administration that is not curative but administered simply to decrease tumor load and increase life expectancy. It has been defined also as ??treatment in circumstances where the impact of intervention is insufficient to result in major survival advantage, but does affect improvement in terms of tumor?related symptoms??">intent</a><a name="SystemicTreatment.intent"> </a></td><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><span style="padding-left: 3px; padding-right: 3px; color: white; background-color: red" title="This element has obligations">O</span></td><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">1..1</td><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R4/datatypes.html#CodeableConcept">CodeableConcept</a></td><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Intent<table class="grid"><tr><td style="font-size: 11px"><b>Obligations</b></td><td style="font-size: 11px"><b>Actor</b></td></tr><tr><td style="font-size: 11px"><b>SHALL</b>:<span title="obligation: handle">handle</span></td><td style="font-size: 11px; opacity: 0.5;"><a href="ActorDefinition-actor-headneck-i4rc.html"/></td></tr></table></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: white; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.setting" title="clarifies the context / how the therapy was administered alone or in conjunction with other treatments
? Neoadjuvant: treatment given as a first step to shrink a tumor before the main treatment, which is usually surgery, is given. Examples of neoadjuvant therapy include chemotherapy, radiation therapy, and hormone therapy. It is a type of induction therapy.
? Adjuvant: additional cancer treatment given after the primary treatment to lower the risk that the cancer will come back. Adjuvant therapy may include chemotherapy, radiation therapy, hormone therapy, targeted therapy, or biological therapy.
? Concomitant/concurrent: A treatment that is given at the same time as another (es. Chemotherapy + radiotherapy).">setting</a><a name="SystemicTreatment.setting"> </a></td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><span style="padding-left: 3px; padding-right: 3px; color: white; background-color: red" title="This element has obligations">O</span></td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">1..1</td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R4/datatypes.html#CodeableConcept">CodeableConcept</a></td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Setting<table class="grid"><tr><td style="font-size: 11px"><b>Obligations</b></td><td style="font-size: 11px"><b>Actor</b></td></tr><tr><td style="font-size: 11px"><b>SHALL</b>:<span title="obligation: handle">handle</span></td><td style="font-size: 11px; opacity: 0.5;"><a href="ActorDefinition-actor-headneck-i4rc.html"/></td></tr></table></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.computedTomographyInfo" title="Information for computed tomography">computedTomographyInfo</a><a name="SystemicTreatment.computedTomographyInfo"> </a></td><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><span style="padding-left: 3px; padding-right: 3px; color: white; background-color: red" title="This element has obligations">O</span></td><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R4/datatypes.html#CodeableConcept">CodeableConcept</a></td><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Computed tomography info<table class="grid"><tr><td style="font-size: 11px"><b>Obligations</b></td><td style="font-size: 11px"><b>Actor</b></td></tr><tr><td style="font-size: 11px"><b>SHALL</b>:<span title="obligation: handle">handle</span></td><td style="font-size: 11px; opacity: 0.5;"><a href="ActorDefinition-actor-sarcoma-i4rc.html"/></td></tr></table></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_primitive.png" alt="." style="background-color: white; background-color: inherit" title="Primitive Data Type" class="hierarchy"/> <a href="StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.startDateSystemicTreatment" title="Specifies when Other treatment begins">startDateSystemicTreatment</a><a name="SystemicTreatment.startDateSystemicTreatment"> </a></td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><span style="padding-left: 3px; padding-right: 3px; color: white; background-color: red" title="This element has obligations">O</span></td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">1..1</td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R4/datatypes.html#date">date</a></td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Start date Systemic treatment<table class="grid"><tr><td style="font-size: 11px"><b>Obligations</b></td><td style="font-size: 11px"><b>Actor</b></td></tr><tr><td style="font-size: 11px"><b>SHALL</b>:<span title="obligation: handle">handle</span></td><td style="font-size: 11px; opacity: 0.5;"><a href="ActorDefinition-actor-headneck-i4rc.html"/></td></tr><tr><td style="font-size: 11px"><b>SHALL</b>:<span title="obligation: handle">handle</span></td><td style="font-size: 11px; opacity: 0.5;"><a href="ActorDefinition-actor-sarcoma-i4rc.html"/></td></tr></table></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_primitive.png" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Primitive Data Type" class="hierarchy"/> <a href="StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.endDateSystemicTreatment" title="Specifies when Other treatment ends">endDateSystemicTreatment</a><a name="SystemicTreatment.endDateSystemicTreatment"> </a></td><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><span style="padding-left: 3px; padding-right: 3px; color: white; background-color: red" title="This element has obligations">O</span></td><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">1..1</td><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R4/datatypes.html#date">date</a></td><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">End date Systemic treatment<table class="grid"><tr><td style="font-size: 11px"><b>Obligations</b></td><td style="font-size: 11px"><b>Actor</b></td></tr><tr><td style="font-size: 11px"><b>SHALL</b>:<span title="obligation: handle">handle</span></td><td style="font-size: 11px; opacity: 0.5;"><a href="ActorDefinition-actor-headneck-i4rc.html"/></td></tr><tr><td style="font-size: 11px"><b>SHALL</b>:<span title="obligation: handle">handle</span></td><td style="font-size: 11px; opacity: 0.5;"><a href="ActorDefinition-actor-sarcoma-i4rc.html"/></td></tr></table></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_primitive.png" alt="." style="background-color: white; background-color: inherit" title="Primitive Data Type" class="hierarchy"/> <a href="StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.numberOfCyclesAdministrations" title="clarifies how many times the treatment was administered. A cycle of treatment is a period of treatment followed by a period of rest (no treatment). For example, treatment given for one week followed by three weeks of rest is one cycle of treatment. A cycle can be repeated multiple times.">numberOfCyclesAdministrations</a><a name="SystemicTreatment.numberOfCyclesAdministrations"> </a></td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><span style="padding-left: 3px; padding-right: 3px; color: white; background-color: red" title="This element has obligations">O</span></td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R4/datatypes.html#decimal">decimal</a></td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Number of cycles/ administrations<table class="grid"><tr><td style="font-size: 11px"><b>Obligations</b></td><td style="font-size: 11px"><b>Actor</b></td></tr><tr><td style="font-size: 11px"><b>SHALL</b>:<span title="obligation: handle">handle</span></td><td style="font-size: 11px; opacity: 0.5;"><a href="ActorDefinition-actor-headneck-i4rc.html"/></td></tr><tr><td style="font-size: 11px"><b>SHALL</b>:<span title="obligation: handle">handle</span></td><td style="font-size: 11px; opacity: 0.5;"><a href="ActorDefinition-actor-sarcoma-i4rc.html"/></td></tr></table></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck11.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.regimen" title="Regimen">regimen</a><a name="SystemicTreatment.regimen"> </a></td><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><span style="padding-left: 3px; padding-right: 3px; color: white; background-color: red" title="This element has obligations">O</span></td><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R4/datatypes.html#BackboneElement">BackboneElement</a></td><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Regimen<table class="grid"><tr><td style="font-size: 11px"><b>Obligations</b></td><td style="font-size: 11px"><b>Actor</b></td></tr><tr><td style="font-size: 11px"><b>SHALL</b>:<span title="obligation: handle">handle</span></td><td style="font-size: 11px; opacity: 0.5;"><a href="ActorDefinition-actor-headneck-i4rc.html"/></td></tr><tr><td style="font-size: 11px"><b>SHALL</b>:<span title="obligation: handle">handle</span></td><td style="font-size: 11px; opacity: 0.5;"><a href="ActorDefinition-actor-sarcoma-i4rc.html"/></td></tr></table></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck110.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vline.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: white; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.regimen.drugs1" title="Drugs 1">drugs1</a><a name="SystemicTreatment.regimen.drugs1"> </a></td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><span style="padding-left: 3px; padding-right: 3px; color: white; background-color: red" title="This element has obligations">O</span></td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">1..1</td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R4/datatypes.html#CodeableConcept">CodeableConcept</a></td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Drugs 1<table class="grid"><tr><td style="font-size: 11px"><b>Obligations</b></td><td style="font-size: 11px"><b>Actor</b></td></tr><tr><td style="font-size: 11px"><b>SHALL</b>:<span title="obligation: handle">handle</span></td><td style="font-size: 11px; opacity: 0.5;"><a href="ActorDefinition-actor-headneck-i4rc.html"/></td></tr><tr><td style="font-size: 11px"><b>SHALL</b>:<span title="obligation: handle">handle</span></td><td style="font-size: 11px; opacity: 0.5;"><a href="ActorDefinition-actor-sarcoma-i4rc.html"/></td></tr></table></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck110.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vline.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.regimen.drugs2" title="Drugs 2">drugs2</a><a name="SystemicTreatment.regimen.drugs2"> </a></td><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><span style="padding-left: 3px; padding-right: 3px; color: white; background-color: red" title="This element has obligations">O</span></td><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">1..1</td><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R4/datatypes.html#CodeableConcept">CodeableConcept</a></td><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Drugs 2<table class="grid"><tr><td style="font-size: 11px"><b>Obligations</b></td><td style="font-size: 11px"><b>Actor</b></td></tr><tr><td style="font-size: 11px"><b>SHALL</b>:<span title="obligation: handle">handle</span></td><td style="font-size: 11px; opacity: 0.5;"><a href="ActorDefinition-actor-headneck-i4rc.html"/></td></tr><tr><td style="font-size: 11px"><b>SHALL</b>:<span title="obligation: handle">handle</span></td><td style="font-size: 11px; opacity: 0.5;"><a href="ActorDefinition-actor-sarcoma-i4rc.html"/></td></tr></table></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck110.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vline.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: white; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.regimen.drugs3" title="Drugs 3">drugs3</a><a name="SystemicTreatment.regimen.drugs3"> </a></td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><span style="padding-left: 3px; padding-right: 3px; color: white; background-color: red" title="This element has obligations">O</span></td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">1..1</td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R4/datatypes.html#CodeableConcept">CodeableConcept</a></td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Drugs 3<table class="grid"><tr><td style="font-size: 11px"><b>Obligations</b></td><td style="font-size: 11px"><b>Actor</b></td></tr><tr><td style="font-size: 11px"><b>SHALL</b>:<span title="obligation: handle">handle</span></td><td style="font-size: 11px; opacity: 0.5;"><a href="ActorDefinition-actor-headneck-i4rc.html"/></td></tr><tr><td style="font-size: 11px"><b>SHALL</b>:<span title="obligation: handle">handle</span></td><td style="font-size: 11px; opacity: 0.5;"><a href="ActorDefinition-actor-sarcoma-i4rc.html"/></td></tr></table></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck110.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vline.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_primitive.png" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Primitive Data Type" class="hierarchy"/> <a href="StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.regimen.startDateRegimenChanged" title="specifies when the new Other treatment begins, if a combination please specify the start of the first drug">startDateRegimenChanged</a><a name="SystemicTreatment.regimen.startDateRegimenChanged"> </a></td><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><span style="padding-left: 3px; padding-right: 3px; color: white; background-color: red" title="This element has obligations">O</span></td><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">1..1</td><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R4/datatypes.html#date">date</a></td><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Start date regimen changed<table class="grid"><tr><td style="font-size: 11px"><b>Obligations</b></td><td style="font-size: 11px"><b>Actor</b></td></tr><tr><td style="font-size: 11px"><b>SHALL</b>:<span title="obligation: handle">handle</span></td><td style="font-size: 11px; opacity: 0.5;"><a href="ActorDefinition-actor-headneck-i4rc.html"/></td></tr></table></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck100.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vline.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin_end.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_primitive.png" alt="." style="background-color: white; background-color: inherit" title="Primitive Data Type" class="hierarchy"/> <a href="StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.regimen.endDateRegimenChanged" title="specifies when the new  Other treatment ends,if a combination please specify the end of the last drug">endDateRegimenChanged</a><a name="SystemicTreatment.regimen.endDateRegimenChanged"> </a></td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><span style="padding-left: 3px; padding-right: 3px; color: white; background-color: red" title="This element has obligations">O</span></td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">1..1</td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R4/datatypes.html#date">date</a></td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">End date regimen changed<table class="grid"><tr><td style="font-size: 11px"><b>Obligations</b></td><td style="font-size: 11px"><b>Actor</b></td></tr><tr><td style="font-size: 11px"><b>SHALL</b>:<span title="obligation: handle">handle</span></td><td style="font-size: 11px; opacity: 0.5;"><a href="ActorDefinition-actor-headneck-i4rc.html"/></td></tr></table></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.reasonForEndOfTreatment" title="Clarifies the reasons why the treatment ended or was interrupted">reasonForEndOfTreatment</a><a name="SystemicTreatment.reasonForEndOfTreatment"> </a></td><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><span style="padding-left: 3px; padding-right: 3px; color: white; background-color: red" title="This element has obligations">O</span></td><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">1..1</td><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R4/datatypes.html#CodeableConcept">CodeableConcept</a></td><td style="vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Reason for end of treatment<table class="grid"><tr><td style="font-size: 11px"><b>Obligations</b></td><td style="font-size: 11px"><b>Actor</b></td></tr><tr><td style="font-size: 11px"><b>SHALL</b>:<span title="obligation: handle">handle</span></td><td style="font-size: 11px; opacity: 0.5;"><a href="ActorDefinition-actor-headneck-i4rc.html"/></td></tr><tr><td style="font-size: 11px"><b>SHALL</b>:<span title="obligation: handle">handle</span></td><td style="font-size: 11px; opacity: 0.5;"><a href="ActorDefinition-actor-sarcoma-i4rc.html"/></td></tr></table></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck00.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin_end.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: white; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.treatmentResponse" title="Measures how well a cancer patient responds to treatment. RECIST criteria should not be applied. The definition of Complete response; Partial response; Stable disease; Progression, should be based on the clinical judgement based on imaging.  Only when setting=neoadiuvant or  palliative">treatmentResponse</a><a name="SystemicTreatment.treatmentResponse"> </a></td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><span style="padding-left: 3px; padding-right: 3px; color: white; background-color: red" title="This element has obligations">O</span></td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">1..1</td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R4/datatypes.html#CodeableConcept">CodeableConcept</a></td><td style="vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Treatment response (based on imaging alone; no recist or other criteria)<table class="grid"><tr><td style="font-size: 11px"><b>Obligations</b></td><td style="font-size: 11px"><b>Actor</b></td></tr><tr><td style="font-size: 11px"><b>SHALL</b>:<span title="obligation: handle">handle</span></td><td style="font-size: 11px; opacity: 0.5;"><a href="ActorDefinition-actor-headneck-i4rc.html"/></td></tr><tr><td style="font-size: 11px"><b>SHALL</b>:<span title="obligation: handle">handle</span></td><td style="font-size: 11px; opacity: 0.5;"><a href="ActorDefinition-actor-sarcoma-i4rc.html"/></td></tr></table></td></tr>
<tr><td colspan="5" class="hierarchy"><br/><a href="https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views" title="Legend for this format"><img src="data:image/png;base64,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" alt="doco" style="background-color: inherit"/> Documentation for this format</a></td></tr></table></div>
  </text>
  <url
       value="http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment"/>
  <version value="0.1.0"/>
  <name value="SystemicTreatmentI4rc"/>
  <title value="Systemic Treatment"/>
  <status value="draft"/>
  <date value="2024-11-12T10:15:38+00:00"/>
  <publisher value="IDEA4RC Project"/>
  <contact>
    <name value="IDEA4RC Project"/>
    <telecom>
      <system value="url"/>
      <value value="https://www.idea4rc.eu/"/>
    </telecom>
  </contact>
  <contact>
    <name value="IDEA4RC Project"/>
    <telecom>
      <system value="url"/>
      <value value="https://www.idea4rc.eu/"/>
    </telecom>
  </contact>
  <description value="Systemic Treatment"/>
  <jurisdiction>
    <coding>
      <system value="http://unstats.un.org/unsd/methods/m49/m49.htm"/>
      <code value="150"/>
      <display value="Europe"/>
    </coding>
  </jurisdiction>
  <fhirVersion value="4.0.1"/>
  <kind value="logical"/>
  <abstract value="false"/>
  <type
        value="http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment"/>
  <baseDefinition value="http://hl7.org/fhir/StructureDefinition/Base"/>
  <derivation value="specialization"/>
  <snapshot>
    <element id="SystemicTreatment">
      <path value="SystemicTreatment"/>
      <short value="Systemic Treatment"/>
      <definition value="Systemic Treatment"/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="Base"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <isModifier value="false"/>
    </element>
    <element id="SystemicTreatment.episodeEventReference">
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"/>
        </extension>
      </extension>
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"/>
        </extension>
      </extension>
      <path value="SystemicTreatment.episodeEventReference"/>
      <short value="Episode Event reference"/>
      <definition
                  value="EpisodeEvent element containing the data regarding the patient's cancer"/>
      <min value="1"/>
      <max value="1"/>
      <base>
        <path value="SystemicTreatment.episodeEventReference"/>
        <min value="1"/>
        <max value="1"/>
      </base>
      <type>
        <code
              value="http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/EpisodeEvent"/>
      </type>
    </element>
    <element id="SystemicTreatment.typeOfSystemicTreatment">
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"/>
        </extension>
      </extension>
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"/>
        </extension>
      </extension>
      <path value="SystemicTreatment.typeOfSystemicTreatment"/>
      <short value="type of Systemic treatment"/>
      <definition
                  value="Select the type of Systemic treatment administered. It is possible to directly select the single treatment as appropriate."/>
      <comment
               value="Chemotherapy; Immunotherapy; Target therapy;  Unknown

Chemotherapy - 4273629
Immunotherapy - 40310107
Target therapy -  40488979
Unknown - 4129922"/>
      <min value="1"/>
      <max value="1"/>
      <base>
        <path value="SystemicTreatment.typeOfSystemicTreatment"/>
        <min value="1"/>
        <max value="1"/>
      </base>
      <type>
        <code value="CodeableConcept"/>
      </type>
    </element>
    <element id="SystemicTreatment.intent">
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"/>
        </extension>
      </extension>
      <path value="SystemicTreatment.intent"/>
      <short value="Intent"/>
      <definition
                  value="Clarifies the reasons why Other therapy is administered
? Curative chemotherapy is chemotherapy administered with the goal of achieving a complete remission and preventing the recurrence of cancer. 
? Palliative chemotherapy refers to any chemotherapy administration that is not curative but administered simply to decrease tumor load and increase life expectancy. It has been defined also as ??treatment in circumstances where the impact of intervention is insufficient to result in major survival advantage, but does affect improvement in terms of tumor?related symptoms??"/>
      <comment
               value="Palliative; Curative; Unknwon
Palliative - 4179711
Curative - 
Unknown - 4129922"/>
      <min value="1"/>
      <max value="1"/>
      <base>
        <path value="SystemicTreatment.intent"/>
        <min value="1"/>
        <max value="1"/>
      </base>
      <type>
        <code value="CodeableConcept"/>
      </type>
    </element>
    <element id="SystemicTreatment.setting">
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"/>
        </extension>
      </extension>
      <path value="SystemicTreatment.setting"/>
      <short value="Setting"/>
      <definition
                  value="clarifies the context / how the therapy was administered alone or in conjunction with other treatments
? Neoadjuvant: treatment given as a first step to shrink a tumor before the main treatment, which is usually surgery, is given. Examples of neoadjuvant therapy include chemotherapy, radiation therapy, and hormone therapy. It is a type of induction therapy.
? Adjuvant: additional cancer treatment given after the primary treatment to lower the risk that the cancer will come back. Adjuvant therapy may include chemotherapy, radiation therapy, hormone therapy, targeted therapy, or biological therapy.
? Concomitant/concurrent: A treatment that is given at the same time as another (es. Chemotherapy + radiotherapy)."/>
      <comment
               value="Neo-adjuvant; Concomitant; Adjuvant; Other tretament alone;  Unknown;
Neo-adjuvant - 44808409
Concomitant - 
 Adjuvant - 44804498
Other tretament alone - 
Unknown - 4129922"/>
      <min value="1"/>
      <max value="1"/>
      <base>
        <path value="SystemicTreatment.setting"/>
        <min value="1"/>
        <max value="1"/>
      </base>
      <type>
        <code value="CodeableConcept"/>
      </type>
    </element>
    <element id="SystemicTreatment.computedTomographyInfo">
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"/>
        </extension>
      </extension>
      <path value="SystemicTreatment.computedTomographyInfo"/>
      <short value="Computed tomography info"/>
      <definition value="Information for computed tomography"/>
      <comment
               value="Pre-operative; Post-operative; Intra-operative (hypertermic intraperiotoneal chemotherapy HIPEC ); therapeutic (without surgery)
Preoperative - 4119031
Postoperative period - 4118656
Hyperthermic intraperitoneal chemotherapy - 3184898
Therapeutic - 4133895"/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="SystemicTreatment.computedTomographyInfo"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="CodeableConcept"/>
      </type>
    </element>
    <element id="SystemicTreatment.startDateSystemicTreatment">
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"/>
        </extension>
      </extension>
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"/>
        </extension>
      </extension>
      <path value="SystemicTreatment.startDateSystemicTreatment"/>
      <short value="Start date Systemic treatment"/>
      <definition value="Specifies when Other treatment begins"/>
      <min value="1"/>
      <max value="1"/>
      <base>
        <path value="SystemicTreatment.startDateSystemicTreatment"/>
        <min value="1"/>
        <max value="1"/>
      </base>
      <type>
        <code value="date"/>
      </type>
    </element>
    <element id="SystemicTreatment.endDateSystemicTreatment">
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"/>
        </extension>
      </extension>
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"/>
        </extension>
      </extension>
      <path value="SystemicTreatment.endDateSystemicTreatment"/>
      <short value="End date Systemic treatment"/>
      <definition value="Specifies when Other treatment ends"/>
      <min value="1"/>
      <max value="1"/>
      <base>
        <path value="SystemicTreatment.endDateSystemicTreatment"/>
        <min value="1"/>
        <max value="1"/>
      </base>
      <type>
        <code value="date"/>
      </type>
    </element>
    <element id="SystemicTreatment.numberOfCyclesAdministrations">
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"/>
        </extension>
      </extension>
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"/>
        </extension>
      </extension>
      <path value="SystemicTreatment.numberOfCyclesAdministrations"/>
      <short value="Number of cycles/ administrations"/>
      <definition
                  value="clarifies how many times the treatment was administered. A cycle of treatment is a period of treatment followed by a period of rest (no treatment). For example, treatment given for one week followed by three weeks of rest is one cycle of treatment. A cycle can be repeated multiple times."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="SystemicTreatment.numberOfCyclesAdministrations"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="decimal"/>
      </type>
    </element>
    <element id="SystemicTreatment.regimen">
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"/>
        </extension>
      </extension>
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"/>
        </extension>
      </extension>
      <path value="SystemicTreatment.regimen"/>
      <short value="Regimen"/>
      <definition value="Regimen"/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="SystemicTreatment.regimen"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="BackboneElement"/>
      </type>
      <constraint>
        <key value="ele-1"/>
        <severity value="error"/>
        <human value="All FHIR elements must have a @value or children"/>
        <expression
                    value="hasValue() or (children().count() &gt; id.count())"/>
        <xpath value="@value|f:*|h:div"/>
        <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
      </constraint>
    </element>
    <element id="SystemicTreatment.regimen.id">
      <path value="SystemicTreatment.regimen.id"/>
      <representation value="xmlAttr"/>
      <short value="Unique id for inter-element referencing"/>
      <definition
                  value="Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="Element.id"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type">
          <valueUrl value="string"/>
        </extension>
        <code value="http://hl7.org/fhirpath/System.String"/>
      </type>
      <isModifier value="false"/>
      <isSummary value="false"/>
      <mapping>
        <identity value="rim"/>
        <map value="n/a"/>
      </mapping>
    </element>
    <element id="SystemicTreatment.regimen.extension">
      <path value="SystemicTreatment.regimen.extension"/>
      <slicing>
        <discriminator>
          <type value="value"/>
          <path value="url"/>
        </discriminator>
        <description value="Extensions are always sliced by (at least) url"/>
        <rules value="open"/>
      </slicing>
      <short value="Additional content defined by implementations"/>
      <definition
                  value="May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension."/>
      <comment
               value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/>
      <alias value="extensions"/>
      <alias value="user content"/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="Element.extension"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="Extension"/>
      </type>
      <constraint>
        <key value="ele-1"/>
        <severity value="error"/>
        <human value="All FHIR elements must have a @value or children"/>
        <expression
                    value="hasValue() or (children().count() &gt; id.count())"/>
        <xpath value="@value|f:*|h:div"/>
        <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
      </constraint>
      <constraint>
        <key value="ext-1"/>
        <severity value="error"/>
        <human value="Must have either extensions or value[x], not both"/>
        <expression value="extension.exists() != value.exists()"/>
        <xpath
               value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), &quot;value&quot;)])"/>
        <source value="http://hl7.org/fhir/StructureDefinition/Extension"/>
      </constraint>
      <isModifier value="false"/>
      <isSummary value="false"/>
      <mapping>
        <identity value="rim"/>
        <map value="n/a"/>
      </mapping>
    </element>
    <element id="SystemicTreatment.regimen.modifierExtension">
      <path value="SystemicTreatment.regimen.modifierExtension"/>
      <short value="Extensions that cannot be ignored even if unrecognized"/>
      <definition
                  value="May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself)."/>
      <comment
               value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/>
      <requirements
                    value="Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R4/extensibility.html#modifierExtension)."/>
      <alias value="extensions"/>
      <alias value="user content"/>
      <alias value="modifiers"/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="BackboneElement.modifierExtension"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="Extension"/>
      </type>
      <constraint>
        <key value="ele-1"/>
        <severity value="error"/>
        <human value="All FHIR elements must have a @value or children"/>
        <expression
                    value="hasValue() or (children().count() &gt; id.count())"/>
        <xpath value="@value|f:*|h:div"/>
        <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
      </constraint>
      <constraint>
        <key value="ext-1"/>
        <severity value="error"/>
        <human value="Must have either extensions or value[x], not both"/>
        <expression value="extension.exists() != value.exists()"/>
        <xpath
               value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), &quot;value&quot;)])"/>
        <source value="http://hl7.org/fhir/StructureDefinition/Extension"/>
      </constraint>
      <isModifier value="true"/>
      <isModifierReason
                        value="Modifier extensions are expected to modify the meaning or interpretation of the element that contains them"/>
      <isSummary value="true"/>
      <mapping>
        <identity value="rim"/>
        <map value="N/A"/>
      </mapping>
    </element>
    <element id="SystemicTreatment.regimen.drugs1">
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"/>
        </extension>
      </extension>
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"/>
        </extension>
      </extension>
      <path value="SystemicTreatment.regimen.drugs1"/>
      <short value="Drugs 1"/>
      <definition value="Drugs 1"/>
      <comment value="ATC list
Athena vocabulary 
ATC"/>
      <min value="1"/>
      <max value="1"/>
      <base>
        <path value="SystemicTreatment.regimen.drugs1"/>
        <min value="1"/>
        <max value="1"/>
      </base>
      <type>
        <code value="CodeableConcept"/>
      </type>
    </element>
    <element id="SystemicTreatment.regimen.drugs2">
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"/>
        </extension>
      </extension>
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"/>
        </extension>
      </extension>
      <path value="SystemicTreatment.regimen.drugs2"/>
      <short value="Drugs 2"/>
      <definition value="Drugs 2"/>
      <comment value="ATC list
Athena vocabulary 
ATC"/>
      <min value="1"/>
      <max value="1"/>
      <base>
        <path value="SystemicTreatment.regimen.drugs2"/>
        <min value="1"/>
        <max value="1"/>
      </base>
      <type>
        <code value="CodeableConcept"/>
      </type>
    </element>
    <element id="SystemicTreatment.regimen.drugs3">
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"/>
        </extension>
      </extension>
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"/>
        </extension>
      </extension>
      <path value="SystemicTreatment.regimen.drugs3"/>
      <short value="Drugs 3"/>
      <definition value="Drugs 3"/>
      <comment value="ATC list
Athena vocabulary 
ATC"/>
      <min value="1"/>
      <max value="1"/>
      <base>
        <path value="SystemicTreatment.regimen.drugs3"/>
        <min value="1"/>
        <max value="1"/>
      </base>
      <type>
        <code value="CodeableConcept"/>
      </type>
    </element>
    <element id="SystemicTreatment.regimen.startDateRegimenChanged">
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"/>
        </extension>
      </extension>
      <path value="SystemicTreatment.regimen.startDateRegimenChanged"/>
      <short value="Start date regimen changed"/>
      <definition
                  value="specifies when the new Other treatment begins, if a combination please specify the start of the first drug"/>
      <min value="1"/>
      <max value="1"/>
      <base>
        <path value="SystemicTreatment.regimen.startDateRegimenChanged"/>
        <min value="1"/>
        <max value="1"/>
      </base>
      <type>
        <code value="date"/>
      </type>
    </element>
    <element id="SystemicTreatment.regimen.endDateRegimenChanged">
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"/>
        </extension>
      </extension>
      <path value="SystemicTreatment.regimen.endDateRegimenChanged"/>
      <short value="End date regimen changed"/>
      <definition
                  value="specifies when the new  Other treatment ends,if a combination please specify the end of the last drug"/>
      <min value="1"/>
      <max value="1"/>
      <base>
        <path value="SystemicTreatment.regimen.endDateRegimenChanged"/>
        <min value="1"/>
        <max value="1"/>
      </base>
      <type>
        <code value="date"/>
      </type>
    </element>
    <element id="SystemicTreatment.reasonForEndOfTreatment">
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"/>
        </extension>
      </extension>
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"/>
        </extension>
      </extension>
      <path value="SystemicTreatment.reasonForEndOfTreatment"/>
      <short value="Reason for end of treatment"/>
      <definition
                  value="Clarifies the reasons why the treatment ended or was interrupted"/>
      <comment
               value="Completion; Toxicity; Comorbidity; Patient  intolerance; Patients decision; Death;  Unknown.
Completion - 4058777 
Toxicity - 438028
Comorbidity - 4162706 
Patient  intolerance -  4105297
Patients decision - 
Death - 4306655
Unknown - 4129922"/>
      <min value="1"/>
      <max value="1"/>
      <base>
        <path value="SystemicTreatment.reasonForEndOfTreatment"/>
        <min value="1"/>
        <max value="1"/>
      </base>
      <type>
        <code value="CodeableConcept"/>
      </type>
    </element>
    <element id="SystemicTreatment.treatmentResponse">
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"/>
        </extension>
      </extension>
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"/>
        </extension>
      </extension>
      <path value="SystemicTreatment.treatmentResponse"/>
      <short
             value="Treatment response (based on imaging alone; no recist or other criteria)"/>
      <definition
                  value="Measures how well a cancer patient responds to treatment. RECIST criteria should not be applied. The definition of Complete response; Partial response; Stable disease; Progression, should be based on the clinical judgement based on imaging.  Only when setting=neoadiuvant or  palliative"/>
      <comment
               value="Complete response; Partial response; Stable disease; Progression; Unknown.
Complete response - 4163135
Partial response -  4161302
Stable disease - 4241442
Progression - 4168352
Unknown - 4129922"/>
      <min value="1"/>
      <max value="1"/>
      <base>
        <path value="SystemicTreatment.treatmentResponse"/>
        <min value="1"/>
        <max value="1"/>
      </base>
      <type>
        <code value="CodeableConcept"/>
      </type>
    </element>
  </snapshot>
  <differential>
    <element id="SystemicTreatment">
      <path value="SystemicTreatment"/>
      <short value="Systemic Treatment"/>
      <definition value="Systemic Treatment"/>
    </element>
    <element id="SystemicTreatment.episodeEventReference">
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"/>
        </extension>
      </extension>
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"/>
        </extension>
      </extension>
      <path value="SystemicTreatment.episodeEventReference"/>
      <short value="Episode Event reference"/>
      <definition
                  value="EpisodeEvent element containing the data regarding the patient's cancer"/>
      <min value="1"/>
      <max value="1"/>
      <type>
        <code
              value="http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/EpisodeEvent"/>
      </type>
    </element>
    <element id="SystemicTreatment.typeOfSystemicTreatment">
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"/>
        </extension>
      </extension>
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"/>
        </extension>
      </extension>
      <path value="SystemicTreatment.typeOfSystemicTreatment"/>
      <short value="type of Systemic treatment"/>
      <definition
                  value="Select the type of Systemic treatment administered. It is possible to directly select the single treatment as appropriate."/>
      <comment
               value="Chemotherapy; Immunotherapy; Target therapy;  Unknown

Chemotherapy - 4273629
Immunotherapy - 40310107
Target therapy -  40488979
Unknown - 4129922"/>
      <min value="1"/>
      <max value="1"/>
      <type>
        <code value="CodeableConcept"/>
      </type>
    </element>
    <element id="SystemicTreatment.intent">
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"/>
        </extension>
      </extension>
      <path value="SystemicTreatment.intent"/>
      <short value="Intent"/>
      <definition
                  value="Clarifies the reasons why Other therapy is administered
? Curative chemotherapy is chemotherapy administered with the goal of achieving a complete remission and preventing the recurrence of cancer. 
? Palliative chemotherapy refers to any chemotherapy administration that is not curative but administered simply to decrease tumor load and increase life expectancy. It has been defined also as ??treatment in circumstances where the impact of intervention is insufficient to result in major survival advantage, but does affect improvement in terms of tumor?related symptoms??"/>
      <comment
               value="Palliative; Curative; Unknwon
Palliative - 4179711
Curative - 
Unknown - 4129922"/>
      <min value="1"/>
      <max value="1"/>
      <type>
        <code value="CodeableConcept"/>
      </type>
    </element>
    <element id="SystemicTreatment.setting">
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"/>
        </extension>
      </extension>
      <path value="SystemicTreatment.setting"/>
      <short value="Setting"/>
      <definition
                  value="clarifies the context / how the therapy was administered alone or in conjunction with other treatments
? Neoadjuvant: treatment given as a first step to shrink a tumor before the main treatment, which is usually surgery, is given. Examples of neoadjuvant therapy include chemotherapy, radiation therapy, and hormone therapy. It is a type of induction therapy.
? Adjuvant: additional cancer treatment given after the primary treatment to lower the risk that the cancer will come back. Adjuvant therapy may include chemotherapy, radiation therapy, hormone therapy, targeted therapy, or biological therapy.
? Concomitant/concurrent: A treatment that is given at the same time as another (es. Chemotherapy + radiotherapy)."/>
      <comment
               value="Neo-adjuvant; Concomitant; Adjuvant; Other tretament alone;  Unknown;
Neo-adjuvant - 44808409
Concomitant - 
 Adjuvant - 44804498
Other tretament alone - 
Unknown - 4129922"/>
      <min value="1"/>
      <max value="1"/>
      <type>
        <code value="CodeableConcept"/>
      </type>
    </element>
    <element id="SystemicTreatment.computedTomographyInfo">
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"/>
        </extension>
      </extension>
      <path value="SystemicTreatment.computedTomographyInfo"/>
      <short value="Computed tomography info"/>
      <definition value="Information for computed tomography"/>
      <comment
               value="Pre-operative; Post-operative; Intra-operative (hypertermic intraperiotoneal chemotherapy HIPEC ); therapeutic (without surgery)
Preoperative - 4119031
Postoperative period - 4118656
Hyperthermic intraperitoneal chemotherapy - 3184898
Therapeutic - 4133895"/>
      <min value="0"/>
      <max value="1"/>
      <type>
        <code value="CodeableConcept"/>
      </type>
    </element>
    <element id="SystemicTreatment.startDateSystemicTreatment">
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"/>
        </extension>
      </extension>
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"/>
        </extension>
      </extension>
      <path value="SystemicTreatment.startDateSystemicTreatment"/>
      <short value="Start date Systemic treatment"/>
      <definition value="Specifies when Other treatment begins"/>
      <min value="1"/>
      <max value="1"/>
      <type>
        <code value="date"/>
      </type>
    </element>
    <element id="SystemicTreatment.endDateSystemicTreatment">
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"/>
        </extension>
      </extension>
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"/>
        </extension>
      </extension>
      <path value="SystemicTreatment.endDateSystemicTreatment"/>
      <short value="End date Systemic treatment"/>
      <definition value="Specifies when Other treatment ends"/>
      <min value="1"/>
      <max value="1"/>
      <type>
        <code value="date"/>
      </type>
    </element>
    <element id="SystemicTreatment.numberOfCyclesAdministrations">
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"/>
        </extension>
      </extension>
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"/>
        </extension>
      </extension>
      <path value="SystemicTreatment.numberOfCyclesAdministrations"/>
      <short value="Number of cycles/ administrations"/>
      <definition
                  value="clarifies how many times the treatment was administered. A cycle of treatment is a period of treatment followed by a period of rest (no treatment). For example, treatment given for one week followed by three weeks of rest is one cycle of treatment. A cycle can be repeated multiple times."/>
      <min value="0"/>
      <max value="1"/>
      <type>
        <code value="decimal"/>
      </type>
    </element>
    <element id="SystemicTreatment.regimen">
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"/>
        </extension>
      </extension>
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"/>
        </extension>
      </extension>
      <path value="SystemicTreatment.regimen"/>
      <short value="Regimen"/>
      <definition value="Regimen"/>
      <min value="0"/>
      <max value="1"/>
      <type>
        <code value="BackboneElement"/>
      </type>
    </element>
    <element id="SystemicTreatment.regimen.drugs1">
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"/>
        </extension>
      </extension>
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"/>
        </extension>
      </extension>
      <path value="SystemicTreatment.regimen.drugs1"/>
      <short value="Drugs 1"/>
      <definition value="Drugs 1"/>
      <comment value="ATC list
Athena vocabulary 
ATC"/>
      <min value="1"/>
      <max value="1"/>
      <type>
        <code value="CodeableConcept"/>
      </type>
    </element>
    <element id="SystemicTreatment.regimen.drugs2">
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"/>
        </extension>
      </extension>
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"/>
        </extension>
      </extension>
      <path value="SystemicTreatment.regimen.drugs2"/>
      <short value="Drugs 2"/>
      <definition value="Drugs 2"/>
      <comment value="ATC list
Athena vocabulary 
ATC"/>
      <min value="1"/>
      <max value="1"/>
      <type>
        <code value="CodeableConcept"/>
      </type>
    </element>
    <element id="SystemicTreatment.regimen.drugs3">
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"/>
        </extension>
      </extension>
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"/>
        </extension>
      </extension>
      <path value="SystemicTreatment.regimen.drugs3"/>
      <short value="Drugs 3"/>
      <definition value="Drugs 3"/>
      <comment value="ATC list
Athena vocabulary 
ATC"/>
      <min value="1"/>
      <max value="1"/>
      <type>
        <code value="CodeableConcept"/>
      </type>
    </element>
    <element id="SystemicTreatment.regimen.startDateRegimenChanged">
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"/>
        </extension>
      </extension>
      <path value="SystemicTreatment.regimen.startDateRegimenChanged"/>
      <short value="Start date regimen changed"/>
      <definition
                  value="specifies when the new Other treatment begins, if a combination please specify the start of the first drug"/>
      <min value="1"/>
      <max value="1"/>
      <type>
        <code value="date"/>
      </type>
    </element>
    <element id="SystemicTreatment.regimen.endDateRegimenChanged">
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"/>
        </extension>
      </extension>
      <path value="SystemicTreatment.regimen.endDateRegimenChanged"/>
      <short value="End date regimen changed"/>
      <definition
                  value="specifies when the new  Other treatment ends,if a combination please specify the end of the last drug"/>
      <min value="1"/>
      <max value="1"/>
      <type>
        <code value="date"/>
      </type>
    </element>
    <element id="SystemicTreatment.reasonForEndOfTreatment">
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"/>
        </extension>
      </extension>
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"/>
        </extension>
      </extension>
      <path value="SystemicTreatment.reasonForEndOfTreatment"/>
      <short value="Reason for end of treatment"/>
      <definition
                  value="Clarifies the reasons why the treatment ended or was interrupted"/>
      <comment
               value="Completion; Toxicity; Comorbidity; Patient  intolerance; Patients decision; Death;  Unknown.
Completion - 4058777 
Toxicity - 438028
Comorbidity - 4162706 
Patient  intolerance -  4105297
Patients decision - 
Death - 4306655
Unknown - 4129922"/>
      <min value="1"/>
      <max value="1"/>
      <type>
        <code value="CodeableConcept"/>
      </type>
    </element>
    <element id="SystemicTreatment.treatmentResponse">
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"/>
        </extension>
      </extension>
      <extension url="http://hl7.org/fhir/StructureDefinition/obligation">
        <extension url="code">
          <valueCode value="SHALL:handle"/>
        </extension>
        <extension url="actor">
          <valueCanonical
                          value="http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"/>
        </extension>
      </extension>
      <path value="SystemicTreatment.treatmentResponse"/>
      <short
             value="Treatment response (based on imaging alone; no recist or other criteria)"/>
      <definition
                  value="Measures how well a cancer patient responds to treatment. RECIST criteria should not be applied. The definition of Complete response; Partial response; Stable disease; Progression, should be based on the clinical judgement based on imaging.  Only when setting=neoadiuvant or  palliative"/>
      <comment
               value="Complete response; Partial response; Stable disease; Progression; Unknown.
Complete response - 4163135
Partial response -  4161302
Stable disease - 4241442
Progression - 4168352
Unknown - 4129922"/>
      <min value="1"/>
      <max value="1"/>
      <type>
        <code value="CodeableConcept"/>
      </type>
    </element>
  </differential>
</StructureDefinition>