Systemic Treatment - TTL Representation - IDEA4RC FHIR Implementation Guide v0.1.0

IDEA4RC FHIR Implementation Guide, published by IDEA4RC Project. This guide is not an authorized publication; it is the continuous build for version 0.1.0 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/hl7-eu/idea4rc/ and changes regularly. See the Directory of published versions
Logical Model: SystemicTreatmentI4rc - TTL Profile

Draft as of 2024-11-12
TTL representation of the SystemicTreatment logical model.
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@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

 a fhir:StructureDefinition ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "SystemicTreatment"] ; # 
  fhir:text [
fhir:status [ fhir:v "extensions" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: StructureDefinition SystemicTreatment</b></p><a name=\"SystemicTreatment\"> </a><a name=\"hcSystemicTreatment\"> </a><a name=\"SystemicTreatment-en-US\"> </a><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" style=\"border: 0px #F0F0F0 solid; font-size: 11px; font-family: verdana; vertical-align: top;\"><tr style=\"border: 1px #F0F0F0 solid; font-size: 11px; font-family: verdana; vertical-align: top\"><th style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views\" title=\"The logical name of the element\">Name</a></th><th style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views\" title=\"Information about the use of the element\">Flags</a></th><th style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views\" title=\"Minimum and Maximum # of times the element can appear in the instance\">Card.</a></th><th style=\"width: 100px\" class=\"hierarchy\"><a href=\"https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views\" title=\"Reference to the type of the element\">Type</a></th><th style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views\" title=\"Additional information about the element\">Description &amp; Constraints</a><span style=\"float: right\"><a href=\"https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views\" title=\"Legend for this format\"><img src=\"data:image/png;base64,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\" alt=\"doco\" style=\"background-color: inherit\"/></a></span></th></tr><tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck1.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment\" title=\"Systemic Treatment\">SystemicTreatment</a><a name=\"SystemicTreatment\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"opacity: 0.5\">0</span><span style=\"opacity: 0.5\">..</span><span style=\"opacity: 0.5\">*</span></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://build.fhir.org/types.html#Base\">Base</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Systemic Treatment<br/><span style=\"font-weight:bold\">Instances of this logical model are not marked to be the target of a Reference</span></td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7\"><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_resource.png\" alt=\".\" style=\"background-color: #F7F7F7; background-color: inherit\" title=\"Resource\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.episodeEventReference\" title=\"EpisodeEvent element containing the data regarding the patient's cancer\">episodeEventReference</a><a name=\"SystemicTreatment.episodeEventReference\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"padding-left: 3px; padding-right: 3px; color: white; background-color: red\" title=\"This element has obligations\">O</span></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"StructureDefinition-EpisodeEvent.html\">EpisodeEvent</a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Episode Event reference<table class=\"grid\"><tr><td style=\"font-size: 11px\"><b>Obligations</b></td><td style=\"font-size: 11px\"><b>Actor</b></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-headneck-i4rc.html\"/></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-sarcoma-i4rc.html\"/></td></tr></table></td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.typeOfSystemicTreatment\" title=\"Select the type of Systemic treatment administered. It is possible to directly select the single treatment as appropriate.\">typeOfSystemicTreatment</a><a name=\"SystemicTreatment.typeOfSystemicTreatment\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"padding-left: 3px; padding-right: 3px; color: white; background-color: red\" title=\"This element has obligations\">O</span></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://hl7.org/fhir/R4/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">type of Systemic treatment<table class=\"grid\"><tr><td style=\"font-size: 11px\"><b>Obligations</b></td><td style=\"font-size: 11px\"><b>Actor</b></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-headneck-i4rc.html\"/></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-sarcoma-i4rc.html\"/></td></tr></table></td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7\"><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: #F7F7F7; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.intent\" title=\"Clarifies the reasons why Other therapy is administered\n? Curative chemotherapy is chemotherapy administered with the goal of achieving a complete remission and preventing the recurrence of cancer. \n? Palliative chemotherapy refers to any chemotherapy administration that is not curative but administered simply to decrease tumor load and increase life expectancy. It has been defined also as ??treatment in circumstances where the impact of intervention is insufficient to result in major survival advantage, but does affect improvement in terms of tumor?related symptoms??\">intent</a><a name=\"SystemicTreatment.intent\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"padding-left: 3px; padding-right: 3px; color: white; background-color: red\" title=\"This element has obligations\">O</span></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://hl7.org/fhir/R4/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Intent<table class=\"grid\"><tr><td style=\"font-size: 11px\"><b>Obligations</b></td><td style=\"font-size: 11px\"><b>Actor</b></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-headneck-i4rc.html\"/></td></tr></table></td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.setting\" title=\"clarifies the context / how the therapy was administered alone or in conjunction with other treatments\n? Neoadjuvant: treatment given as a first step to shrink a tumor before the main treatment, which is usually surgery, is given. Examples of neoadjuvant therapy include chemotherapy, radiation therapy, and hormone therapy. It is a type of induction therapy.\n? Adjuvant: additional cancer treatment given after the primary treatment to lower the risk that the cancer will come back. Adjuvant therapy may include chemotherapy, radiation therapy, hormone therapy, targeted therapy, or biological therapy.\n? Concomitant/concurrent: A treatment that is given at the same time as another (es. Chemotherapy + radiotherapy).\">setting</a><a name=\"SystemicTreatment.setting\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"padding-left: 3px; padding-right: 3px; color: white; background-color: red\" title=\"This element has obligations\">O</span></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://hl7.org/fhir/R4/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Setting<table class=\"grid\"><tr><td style=\"font-size: 11px\"><b>Obligations</b></td><td style=\"font-size: 11px\"><b>Actor</b></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-headneck-i4rc.html\"/></td></tr></table></td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7\"><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: #F7F7F7; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.computedTomographyInfo\" title=\"Information for computed tomography\">computedTomographyInfo</a><a name=\"SystemicTreatment.computedTomographyInfo\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"padding-left: 3px; padding-right: 3px; color: white; background-color: red\" title=\"This element has obligations\">O</span></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://hl7.org/fhir/R4/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Computed tomography info<table class=\"grid\"><tr><td style=\"font-size: 11px\"><b>Obligations</b></td><td style=\"font-size: 11px\"><b>Actor</b></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-sarcoma-i4rc.html\"/></td></tr></table></td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_primitive.png\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Primitive Data Type\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.startDateSystemicTreatment\" title=\"Specifies when Other treatment begins\">startDateSystemicTreatment</a><a name=\"SystemicTreatment.startDateSystemicTreatment\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"padding-left: 3px; padding-right: 3px; color: white; background-color: red\" title=\"This element has obligations\">O</span></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://hl7.org/fhir/R4/datatypes.html#date\">date</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Start date Systemic treatment<table class=\"grid\"><tr><td style=\"font-size: 11px\"><b>Obligations</b></td><td style=\"font-size: 11px\"><b>Actor</b></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-headneck-i4rc.html\"/></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-sarcoma-i4rc.html\"/></td></tr></table></td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7\"><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_primitive.png\" alt=\".\" style=\"background-color: #F7F7F7; background-color: inherit\" title=\"Primitive Data Type\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.endDateSystemicTreatment\" title=\"Specifies when Other treatment ends\">endDateSystemicTreatment</a><a name=\"SystemicTreatment.endDateSystemicTreatment\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"padding-left: 3px; padding-right: 3px; color: white; background-color: red\" title=\"This element has obligations\">O</span></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://hl7.org/fhir/R4/datatypes.html#date\">date</a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">End date Systemic treatment<table class=\"grid\"><tr><td style=\"font-size: 11px\"><b>Obligations</b></td><td style=\"font-size: 11px\"><b>Actor</b></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-headneck-i4rc.html\"/></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-sarcoma-i4rc.html\"/></td></tr></table></td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_primitive.png\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Primitive Data Type\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.numberOfCyclesAdministrations\" title=\"clarifies how many times the treatment was administered. A cycle of treatment is a period of treatment followed by a period of rest (no treatment). For example, treatment given for one week followed by three weeks of rest is one cycle of treatment. A cycle can be repeated multiple times.\">numberOfCyclesAdministrations</a><a name=\"SystemicTreatment.numberOfCyclesAdministrations\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"padding-left: 3px; padding-right: 3px; color: white; background-color: red\" title=\"This element has obligations\">O</span></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://hl7.org/fhir/R4/datatypes.html#decimal\">decimal</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Number of cycles/ administrations<table class=\"grid\"><tr><td style=\"font-size: 11px\"><b>Obligations</b></td><td style=\"font-size: 11px\"><b>Actor</b></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-headneck-i4rc.html\"/></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-sarcoma-i4rc.html\"/></td></tr></table></td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7\"><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck11.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: #F7F7F7; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.regimen\" title=\"Regimen\">regimen</a><a name=\"SystemicTreatment.regimen\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"padding-left: 3px; padding-right: 3px; color: white; background-color: red\" title=\"This element has obligations\">O</span></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://hl7.org/fhir/R4/datatypes.html#BackboneElement\">BackboneElement</a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Regimen<table class=\"grid\"><tr><td style=\"font-size: 11px\"><b>Obligations</b></td><td style=\"font-size: 11px\"><b>Actor</b></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-headneck-i4rc.html\"/></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-sarcoma-i4rc.html\"/></td></tr></table></td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck110.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.regimen.drugs1\" title=\"Drugs 1\">drugs1</a><a name=\"SystemicTreatment.regimen.drugs1\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"padding-left: 3px; padding-right: 3px; color: white; background-color: red\" title=\"This element has obligations\">O</span></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://hl7.org/fhir/R4/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Drugs 1<table class=\"grid\"><tr><td style=\"font-size: 11px\"><b>Obligations</b></td><td style=\"font-size: 11px\"><b>Actor</b></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-headneck-i4rc.html\"/></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-sarcoma-i4rc.html\"/></td></tr></table></td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7\"><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck110.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: #F7F7F7; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.regimen.drugs2\" title=\"Drugs 2\">drugs2</a><a name=\"SystemicTreatment.regimen.drugs2\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"padding-left: 3px; padding-right: 3px; color: white; background-color: red\" title=\"This element has obligations\">O</span></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://hl7.org/fhir/R4/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Drugs 2<table class=\"grid\"><tr><td style=\"font-size: 11px\"><b>Obligations</b></td><td style=\"font-size: 11px\"><b>Actor</b></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-headneck-i4rc.html\"/></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-sarcoma-i4rc.html\"/></td></tr></table></td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck110.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.regimen.drugs3\" title=\"Drugs 3\">drugs3</a><a name=\"SystemicTreatment.regimen.drugs3\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"padding-left: 3px; padding-right: 3px; color: white; background-color: red\" title=\"This element has obligations\">O</span></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://hl7.org/fhir/R4/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Drugs 3<table class=\"grid\"><tr><td style=\"font-size: 11px\"><b>Obligations</b></td><td style=\"font-size: 11px\"><b>Actor</b></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-headneck-i4rc.html\"/></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-sarcoma-i4rc.html\"/></td></tr></table></td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7\"><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck110.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_primitive.png\" alt=\".\" style=\"background-color: #F7F7F7; background-color: inherit\" title=\"Primitive Data Type\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.regimen.startDateRegimenChanged\" title=\"specifies when the new Other treatment begins, if a combination please specify the start of the first drug\">startDateRegimenChanged</a><a name=\"SystemicTreatment.regimen.startDateRegimenChanged\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"padding-left: 3px; padding-right: 3px; color: white; background-color: red\" title=\"This element has obligations\">O</span></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://hl7.org/fhir/R4/datatypes.html#date\">date</a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Start date regimen changed<table class=\"grid\"><tr><td style=\"font-size: 11px\"><b>Obligations</b></td><td style=\"font-size: 11px\"><b>Actor</b></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-headneck-i4rc.html\"/></td></tr></table></td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck100.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_primitive.png\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Primitive Data Type\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.regimen.endDateRegimenChanged\" title=\"specifies when the new  Other treatment ends,if a combination please specify the end of the last drug\">endDateRegimenChanged</a><a name=\"SystemicTreatment.regimen.endDateRegimenChanged\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"padding-left: 3px; padding-right: 3px; color: white; background-color: red\" title=\"This element has obligations\">O</span></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://hl7.org/fhir/R4/datatypes.html#date\">date</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">End date regimen changed<table class=\"grid\"><tr><td style=\"font-size: 11px\"><b>Obligations</b></td><td style=\"font-size: 11px\"><b>Actor</b></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-headneck-i4rc.html\"/></td></tr></table></td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7\"><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: #F7F7F7; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.reasonForEndOfTreatment\" title=\"Clarifies the reasons why the treatment ended or was interrupted\">reasonForEndOfTreatment</a><a name=\"SystemicTreatment.reasonForEndOfTreatment\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"padding-left: 3px; padding-right: 3px; color: white; background-color: red\" title=\"This element has obligations\">O</span></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://hl7.org/fhir/R4/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Reason for end of treatment<table class=\"grid\"><tr><td style=\"font-size: 11px\"><b>Obligations</b></td><td style=\"font-size: 11px\"><b>Actor</b></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-headneck-i4rc.html\"/></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-sarcoma-i4rc.html\"/></td></tr></table></td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck00.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"StructureDefinition-SystemicTreatment-definitions.html#SystemicTreatment.treatmentResponse\" title=\"Measures how well a cancer patient responds to treatment. RECIST criteria should not be applied. The definition of Complete response; Partial response; Stable disease; Progression, should be based on the clinical judgement based on imaging.  Only when setting=neoadiuvant or  palliative\">treatmentResponse</a><a name=\"SystemicTreatment.treatmentResponse\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><span style=\"padding-left: 3px; padding-right: 3px; color: white; background-color: red\" title=\"This element has obligations\">O</span></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://hl7.org/fhir/R4/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Treatment response (based on imaging alone; no recist or other criteria)<table class=\"grid\"><tr><td style=\"font-size: 11px\"><b>Obligations</b></td><td style=\"font-size: 11px\"><b>Actor</b></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-headneck-i4rc.html\"/></td></tr><tr><td style=\"font-size: 11px\"><b>SHALL</b>:<span title=\"obligation: handle\">handle</span></td><td style=\"font-size: 11px; opacity: 0.5;\"><a href=\"ActorDefinition-actor-sarcoma-i4rc.html\"/></td></tr></table></td></tr>\r\n<tr><td colspan=\"5\" class=\"hierarchy\"><br/><a href=\"https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views\" title=\"Legend for this format\"><img src=\"data:image/png;base64,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\" alt=\"doco\" style=\"background-color: inherit\"/> Documentation for this format</a></td></tr></table></div>"
  ] ; # 
  fhir:url [ fhir:v "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment"^^xsd:anyURI] ; # 
  fhir:version [ fhir:v "0.1.0"] ; # 
  fhir:name [ fhir:v "SystemicTreatmentI4rc"] ; # 
  fhir:title [ fhir:v "Systemic Treatment"] ; # 
  fhir:status [ fhir:v "draft"] ; # 
  fhir:date [ fhir:v "2024-11-12T10:15:38+00:00"^^xsd:dateTime] ; # 
  fhir:publisher [ fhir:v "IDEA4RC Project"] ; # 
  fhir:contact ( [
fhir:name [ fhir:v "IDEA4RC Project" ] ;
    ( fhir:telecom [
fhir:system [ fhir:v "url" ] ;
fhir:value [ fhir:v "https://www.idea4rc.eu/" ]     ] )
  ] [
fhir:name [ fhir:v "IDEA4RC Project" ] ;
    ( fhir:telecom [
fhir:system [ fhir:v "url" ] ;
fhir:value [ fhir:v "https://www.idea4rc.eu/" ]     ] )
  ] ) ; # 
  fhir:description [ fhir:v "Systemic Treatment"] ; # 
  fhir:jurisdiction ( [
    ( fhir:coding [
fhir:system [ fhir:v "http://unstats.un.org/unsd/methods/m49/m49.htm"^^xsd:anyURI ] ;
fhir:code [ fhir:v "150" ] ;
fhir:display [ fhir:v "Europe" ]     ] )
  ] ) ; # 
  fhir:fhirVersion [ fhir:v "4.0.1"] ; # 
  fhir:kind [ fhir:v "logical"] ; # 
  fhir:abstract [ fhir:v "false"^^xsd:boolean] ; # 
  fhir:type [ fhir:v "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment"^^xsd:anyURI] ; # 
  fhir:baseDefinition [
fhir:v "http://hl7.org/fhir/StructureDefinition/Base"^^xsd:anyURI ;
fhir:link <http://hl7.org/fhir/StructureDefinition/Base>
  ] ; # 
  fhir:derivation [ fhir:v "specialization"] ; # 
  fhir:snapshot [
    ( fhir:element [
fhir:id [ fhir:v "SystemicTreatment" ] ;
fhir:path [ fhir:v "SystemicTreatment" ] ;
fhir:short [ fhir:v "Systemic Treatment" ] ;
fhir:definition [ fhir:v "Systemic Treatment" ] ;
fhir:min [ fhir:v "0"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "*" ] ;
fhir:base [
fhir:path [ fhir:v "Base" ] ;
fhir:min [ fhir:v "0"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "*" ]       ] ;
fhir:isModifier [ fhir:v "false"^^xsd:boolean ]     ] [
fhir:id [ fhir:v "SystemicTreatment.episodeEventReference" ] ;
      ( fhir:extension [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] ) ;
fhir:path [ fhir:v "SystemicTreatment.episodeEventReference" ] ;
fhir:short [ fhir:v "Episode Event reference" ] ;
fhir:definition [ fhir:v "EpisodeEvent element containing the data regarding the patient's cancer" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
fhir:base [
fhir:path [ fhir:v "SystemicTreatment.episodeEventReference" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ]       ] ;
      ( fhir:type [
fhir:code [ fhir:v "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/EpisodeEvent"^^xsd:anyURI ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.typeOfSystemicTreatment" ] ;
      ( fhir:extension [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] ) ;
fhir:path [ fhir:v "SystemicTreatment.typeOfSystemicTreatment" ] ;
fhir:short [ fhir:v "type of Systemic treatment" ] ;
fhir:definition [ fhir:v "Select the type of Systemic treatment administered. It is possible to directly select the single treatment as appropriate." ] ;
fhir:comment [ fhir:v "Chemotherapy; Immunotherapy; Target therapy;  Unknown\n\nChemotherapy - 4273629\nImmunotherapy - 40310107\nTarget therapy -  40488979\nUnknown - 4129922" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
fhir:base [
fhir:path [ fhir:v "SystemicTreatment.typeOfSystemicTreatment" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ]       ] ;
      ( fhir:type [
fhir:code [ fhir:v "CodeableConcept"^^xsd:anyURI ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.intent" ] ;
      ( fhir:extension [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] ) ;
fhir:path [ fhir:v "SystemicTreatment.intent" ] ;
fhir:short [ fhir:v "Intent" ] ;
fhir:definition [ fhir:v "Clarifies the reasons why Other therapy is administered\n? Curative chemotherapy is chemotherapy administered with the goal of achieving a complete remission and preventing the recurrence of cancer. \n? Palliative chemotherapy refers to any chemotherapy administration that is not curative but administered simply to decrease tumor load and increase life expectancy. It has been defined also as ??treatment in circumstances where the impact of intervention is insufficient to result in major survival advantage, but does affect improvement in terms of tumor?related symptoms??" ] ;
fhir:comment [ fhir:v "Palliative; Curative; Unknwon\nPalliative - 4179711\nCurative - \nUnknown - 4129922" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
fhir:base [
fhir:path [ fhir:v "SystemicTreatment.intent" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ]       ] ;
      ( fhir:type [
fhir:code [ fhir:v "CodeableConcept"^^xsd:anyURI ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.setting" ] ;
      ( fhir:extension [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] ) ;
fhir:path [ fhir:v "SystemicTreatment.setting" ] ;
fhir:short [ fhir:v "Setting" ] ;
fhir:definition [ fhir:v "clarifies the context / how the therapy was administered alone or in conjunction with other treatments\n? Neoadjuvant: treatment given as a first step to shrink a tumor before the main treatment, which is usually surgery, is given. Examples of neoadjuvant therapy include chemotherapy, radiation therapy, and hormone therapy. It is a type of induction therapy.\n? Adjuvant: additional cancer treatment given after the primary treatment to lower the risk that the cancer will come back. Adjuvant therapy may include chemotherapy, radiation therapy, hormone therapy, targeted therapy, or biological therapy.\n? Concomitant/concurrent: A treatment that is given at the same time as another (es. Chemotherapy + radiotherapy)." ] ;
fhir:comment [ fhir:v "Neo-adjuvant; Concomitant; Adjuvant; Other tretament alone;  Unknown;\nNeo-adjuvant - 44808409\nConcomitant - \n Adjuvant - 44804498\nOther tretament alone - \nUnknown - 4129922" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
fhir:base [
fhir:path [ fhir:v "SystemicTreatment.setting" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ]       ] ;
      ( fhir:type [
fhir:code [ fhir:v "CodeableConcept"^^xsd:anyURI ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.computedTomographyInfo" ] ;
      ( fhir:extension [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] ) ;
fhir:path [ fhir:v "SystemicTreatment.computedTomographyInfo" ] ;
fhir:short [ fhir:v "Computed tomography info" ] ;
fhir:definition [ fhir:v "Information for computed tomography" ] ;
fhir:comment [ fhir:v "Pre-operative; Post-operative; Intra-operative (hypertermic intraperiotoneal chemotherapy HIPEC ); therapeutic (without surgery)\nPreoperative - 4119031\nPostoperative period - 4118656\nHyperthermic intraperitoneal chemotherapy - 3184898\nTherapeutic - 4133895" ] ;
fhir:min [ fhir:v "0"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
fhir:base [
fhir:path [ fhir:v "SystemicTreatment.computedTomographyInfo" ] ;
fhir:min [ fhir:v "0"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ]       ] ;
      ( fhir:type [
fhir:code [ fhir:v "CodeableConcept"^^xsd:anyURI ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.startDateSystemicTreatment" ] ;
      ( fhir:extension [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] ) ;
fhir:path [ fhir:v "SystemicTreatment.startDateSystemicTreatment" ] ;
fhir:short [ fhir:v "Start date Systemic treatment" ] ;
fhir:definition [ fhir:v "Specifies when Other treatment begins" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
fhir:base [
fhir:path [ fhir:v "SystemicTreatment.startDateSystemicTreatment" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ]       ] ;
      ( fhir:type [
fhir:code [ fhir:v "date"^^xsd:anyURI ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.endDateSystemicTreatment" ] ;
      ( fhir:extension [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] ) ;
fhir:path [ fhir:v "SystemicTreatment.endDateSystemicTreatment" ] ;
fhir:short [ fhir:v "End date Systemic treatment" ] ;
fhir:definition [ fhir:v "Specifies when Other treatment ends" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
fhir:base [
fhir:path [ fhir:v "SystemicTreatment.endDateSystemicTreatment" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ]       ] ;
      ( fhir:type [
fhir:code [ fhir:v "date"^^xsd:anyURI ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.numberOfCyclesAdministrations" ] ;
      ( fhir:extension [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] ) ;
fhir:path [ fhir:v "SystemicTreatment.numberOfCyclesAdministrations" ] ;
fhir:short [ fhir:v "Number of cycles/ administrations" ] ;
fhir:definition [ fhir:v "clarifies how many times the treatment was administered. A cycle of treatment is a period of treatment followed by a period of rest (no treatment). For example, treatment given for one week followed by three weeks of rest is one cycle of treatment. A cycle can be repeated multiple times." ] ;
fhir:min [ fhir:v "0"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
fhir:base [
fhir:path [ fhir:v "SystemicTreatment.numberOfCyclesAdministrations" ] ;
fhir:min [ fhir:v "0"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ]       ] ;
      ( fhir:type [
fhir:code [ fhir:v "decimal"^^xsd:anyURI ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.regimen" ] ;
      ( fhir:extension [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] ) ;
fhir:path [ fhir:v "SystemicTreatment.regimen" ] ;
fhir:short [ fhir:v "Regimen" ] ;
fhir:definition [ fhir:v "Regimen" ] ;
fhir:min [ fhir:v "0"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
fhir:base [
fhir:path [ fhir:v "SystemicTreatment.regimen" ] ;
fhir:min [ fhir:v "0"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ]       ] ;
      ( fhir:type [
fhir:code [ fhir:v "BackboneElement"^^xsd:anyURI ]       ] ) ;
      ( fhir:constraint [
fhir:key [ fhir:v "ele-1" ] ;
fhir:severity [ fhir:v "error" ] ;
fhir:human [ fhir:v "All FHIR elements must have a @value or children" ] ;
fhir:expression [ fhir:v "hasValue() or (children().count() > id.count())" ] ;
fhir:xpath [ fhir:v "@value|f:*|h:div" ] ;
fhir:source [
fhir:v "http://hl7.org/fhir/StructureDefinition/Element"^^xsd:anyURI ;
fhir:link <http://hl7.org/fhir/StructureDefinition/Element>         ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.regimen.id" ] ;
fhir:path [ fhir:v "SystemicTreatment.regimen.id" ] ;
      ( fhir:representation [ fhir:v "xmlAttr" ] ) ;
fhir:short [ fhir:v "Unique id for inter-element referencing" ] ;
fhir:definition [ fhir:v "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces." ] ;
fhir:min [ fhir:v "0"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
fhir:base [
fhir:path [ fhir:v "Element.id" ] ;
fhir:min [ fhir:v "0"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ]       ] ;
      ( fhir:type [
        ( fhir:extension [
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type"^^xsd:anyURI ] ;
fhir:value [ fhir:v "string"^^xsd:anyURI ]         ] ) ;
fhir:code [ fhir:v "http://hl7.org/fhirpath/System.String"^^xsd:anyURI ]       ] ) ;
fhir:isModifier [ fhir:v "false"^^xsd:boolean ] ;
fhir:isSummary [ fhir:v "false"^^xsd:boolean ] ;
      ( fhir:mapping [
fhir:identity [ fhir:v "rim" ] ;
fhir:map [ fhir:v "n/a" ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.regimen.extension" ] ;
fhir:path [ fhir:v "SystemicTreatment.regimen.extension" ] ;
fhir:slicing [
        ( fhir:discriminator [
fhir:type [ fhir:v "value" ] ;
fhir:path [ fhir:v "url" ]         ] ) ;
fhir:description [ fhir:v "Extensions are always sliced by (at least) url" ] ;
fhir:rules [ fhir:v "open" ]       ] ;
fhir:short [ fhir:v "Additional content defined by implementations" ] ;
fhir:definition [ fhir:v "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension." ] ;
fhir:comment [ fhir:v "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." ] ;
      ( fhir:alias [ fhir:v "extensions" ] [ fhir:v "user content" ] ) ;
fhir:min [ fhir:v "0"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "*" ] ;
fhir:base [
fhir:path [ fhir:v "Element.extension" ] ;
fhir:min [ fhir:v "0"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "*" ]       ] ;
      ( fhir:type [
fhir:code [ fhir:v "Extension"^^xsd:anyURI ]       ] ) ;
      ( fhir:constraint [
fhir:key [ fhir:v "ele-1" ] ;
fhir:severity [ fhir:v "error" ] ;
fhir:human [ fhir:v "All FHIR elements must have a @value or children" ] ;
fhir:expression [ fhir:v "hasValue() or (children().count() > id.count())" ] ;
fhir:xpath [ fhir:v "@value|f:*|h:div" ] ;
fhir:source [
fhir:v "http://hl7.org/fhir/StructureDefinition/Element"^^xsd:anyURI ;
fhir:link <http://hl7.org/fhir/StructureDefinition/Element>         ]       ] [
fhir:key [ fhir:v "ext-1" ] ;
fhir:severity [ fhir:v "error" ] ;
fhir:human [ fhir:v "Must have either extensions or value[x], not both" ] ;
fhir:expression [ fhir:v "extension.exists() != value.exists()" ] ;
fhir:xpath [ fhir:v "exists(f:extension)!=exists(f:*[starts-with(local-name(.), \"value\")])" ] ;
fhir:source [
fhir:v "http://hl7.org/fhir/StructureDefinition/Extension"^^xsd:anyURI ;
fhir:link <http://hl7.org/fhir/StructureDefinition/Extension>         ]       ] ) ;
fhir:isModifier [ fhir:v "false"^^xsd:boolean ] ;
fhir:isSummary [ fhir:v "false"^^xsd:boolean ] ;
      ( fhir:mapping [
fhir:identity [ fhir:v "rim" ] ;
fhir:map [ fhir:v "n/a" ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.regimen.modifierExtension" ] ;
fhir:path [ fhir:v "SystemicTreatment.regimen.modifierExtension" ] ;
fhir:short [ fhir:v "Extensions that cannot be ignored even if unrecognized" ] ;
fhir:definition [ fhir:v "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself)." ] ;
fhir:comment [ fhir:v "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." ] ;
fhir:requirements [ fhir:v "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R4/extensibility.html#modifierExtension)." ] ;
      ( fhir:alias [ fhir:v "extensions" ] [ fhir:v "user content" ] [ fhir:v "modifiers" ] ) ;
fhir:min [ fhir:v "0"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "*" ] ;
fhir:base [
fhir:path [ fhir:v "BackboneElement.modifierExtension" ] ;
fhir:min [ fhir:v "0"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "*" ]       ] ;
      ( fhir:type [
fhir:code [ fhir:v "Extension"^^xsd:anyURI ]       ] ) ;
      ( fhir:constraint [
fhir:key [ fhir:v "ele-1" ] ;
fhir:severity [ fhir:v "error" ] ;
fhir:human [ fhir:v "All FHIR elements must have a @value or children" ] ;
fhir:expression [ fhir:v "hasValue() or (children().count() > id.count())" ] ;
fhir:xpath [ fhir:v "@value|f:*|h:div" ] ;
fhir:source [
fhir:v "http://hl7.org/fhir/StructureDefinition/Element"^^xsd:anyURI ;
fhir:link <http://hl7.org/fhir/StructureDefinition/Element>         ]       ] [
fhir:key [ fhir:v "ext-1" ] ;
fhir:severity [ fhir:v "error" ] ;
fhir:human [ fhir:v "Must have either extensions or value[x], not both" ] ;
fhir:expression [ fhir:v "extension.exists() != value.exists()" ] ;
fhir:xpath [ fhir:v "exists(f:extension)!=exists(f:*[starts-with(local-name(.), \"value\")])" ] ;
fhir:source [
fhir:v "http://hl7.org/fhir/StructureDefinition/Extension"^^xsd:anyURI ;
fhir:link <http://hl7.org/fhir/StructureDefinition/Extension>         ]       ] ) ;
fhir:isModifier [ fhir:v "true"^^xsd:boolean ] ;
fhir:isModifierReason [ fhir:v "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them" ] ;
fhir:isSummary [ fhir:v "true"^^xsd:boolean ] ;
      ( fhir:mapping [
fhir:identity [ fhir:v "rim" ] ;
fhir:map [ fhir:v "N/A" ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.regimen.drugs1" ] ;
      ( fhir:extension [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] ) ;
fhir:path [ fhir:v "SystemicTreatment.regimen.drugs1" ] ;
fhir:short [ fhir:v "Drugs 1" ] ;
fhir:definition [ fhir:v "Drugs 1" ] ;
fhir:comment [ fhir:v "ATC list\nAthena vocabulary \nATC" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
fhir:base [
fhir:path [ fhir:v "SystemicTreatment.regimen.drugs1" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ]       ] ;
      ( fhir:type [
fhir:code [ fhir:v "CodeableConcept"^^xsd:anyURI ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.regimen.drugs2" ] ;
      ( fhir:extension [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] ) ;
fhir:path [ fhir:v "SystemicTreatment.regimen.drugs2" ] ;
fhir:short [ fhir:v "Drugs 2" ] ;
fhir:definition [ fhir:v "Drugs 2" ] ;
fhir:comment [ fhir:v "ATC list\nAthena vocabulary \nATC" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
fhir:base [
fhir:path [ fhir:v "SystemicTreatment.regimen.drugs2" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ]       ] ;
      ( fhir:type [
fhir:code [ fhir:v "CodeableConcept"^^xsd:anyURI ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.regimen.drugs3" ] ;
      ( fhir:extension [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] ) ;
fhir:path [ fhir:v "SystemicTreatment.regimen.drugs3" ] ;
fhir:short [ fhir:v "Drugs 3" ] ;
fhir:definition [ fhir:v "Drugs 3" ] ;
fhir:comment [ fhir:v "ATC list\nAthena vocabulary \nATC" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
fhir:base [
fhir:path [ fhir:v "SystemicTreatment.regimen.drugs3" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ]       ] ;
      ( fhir:type [
fhir:code [ fhir:v "CodeableConcept"^^xsd:anyURI ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.regimen.startDateRegimenChanged" ] ;
      ( fhir:extension [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] ) ;
fhir:path [ fhir:v "SystemicTreatment.regimen.startDateRegimenChanged" ] ;
fhir:short [ fhir:v "Start date regimen changed" ] ;
fhir:definition [ fhir:v "specifies when the new Other treatment begins, if a combination please specify the start of the first drug" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
fhir:base [
fhir:path [ fhir:v "SystemicTreatment.regimen.startDateRegimenChanged" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ]       ] ;
      ( fhir:type [
fhir:code [ fhir:v "date"^^xsd:anyURI ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.regimen.endDateRegimenChanged" ] ;
      ( fhir:extension [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] ) ;
fhir:path [ fhir:v "SystemicTreatment.regimen.endDateRegimenChanged" ] ;
fhir:short [ fhir:v "End date regimen changed" ] ;
fhir:definition [ fhir:v "specifies when the new  Other treatment ends,if a combination please specify the end of the last drug" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
fhir:base [
fhir:path [ fhir:v "SystemicTreatment.regimen.endDateRegimenChanged" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ]       ] ;
      ( fhir:type [
fhir:code [ fhir:v "date"^^xsd:anyURI ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.reasonForEndOfTreatment" ] ;
      ( fhir:extension [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] ) ;
fhir:path [ fhir:v "SystemicTreatment.reasonForEndOfTreatment" ] ;
fhir:short [ fhir:v "Reason for end of treatment" ] ;
fhir:definition [ fhir:v "Clarifies the reasons why the treatment ended or was interrupted" ] ;
fhir:comment [ fhir:v "Completion; Toxicity; Comorbidity; Patient  intolerance; Patients decision; Death;  Unknown.\nCompletion - 4058777 \nToxicity - 438028\nComorbidity - 4162706 \nPatient  intolerance -  4105297\nPatients decision - \nDeath - 4306655\nUnknown - 4129922" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
fhir:base [
fhir:path [ fhir:v "SystemicTreatment.reasonForEndOfTreatment" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ]       ] ;
      ( fhir:type [
fhir:code [ fhir:v "CodeableConcept"^^xsd:anyURI ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.treatmentResponse" ] ;
      ( fhir:extension [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] ) ;
fhir:path [ fhir:v "SystemicTreatment.treatmentResponse" ] ;
fhir:short [ fhir:v "Treatment response (based on imaging alone; no recist or other criteria)" ] ;
fhir:definition [ fhir:v "Measures how well a cancer patient responds to treatment. RECIST criteria should not be applied. The definition of Complete response; Partial response; Stable disease; Progression, should be based on the clinical judgement based on imaging.  Only when setting=neoadiuvant or  palliative" ] ;
fhir:comment [ fhir:v "Complete response; Partial response; Stable disease; Progression; Unknown.\nComplete response - 4163135\nPartial response -  4161302\nStable disease - 4241442\nProgression - 4168352\nUnknown - 4129922" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
fhir:base [
fhir:path [ fhir:v "SystemicTreatment.treatmentResponse" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ]       ] ;
      ( fhir:type [
fhir:code [ fhir:v "CodeableConcept"^^xsd:anyURI ]       ] )     ] )
  ] ; # 
  fhir:differential [
    ( fhir:element [
fhir:id [ fhir:v "SystemicTreatment" ] ;
fhir:path [ fhir:v "SystemicTreatment" ] ;
fhir:short [ fhir:v "Systemic Treatment" ] ;
fhir:definition [ fhir:v "Systemic Treatment" ]     ] [
fhir:id [ fhir:v "SystemicTreatment.episodeEventReference" ] ;
      ( fhir:extension [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] ) ;
fhir:path [ fhir:v "SystemicTreatment.episodeEventReference" ] ;
fhir:short [ fhir:v "Episode Event reference" ] ;
fhir:definition [ fhir:v "EpisodeEvent element containing the data regarding the patient's cancer" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
      ( fhir:type [
fhir:code [ fhir:v "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/EpisodeEvent"^^xsd:anyURI ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.typeOfSystemicTreatment" ] ;
      ( fhir:extension [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] ) ;
fhir:path [ fhir:v "SystemicTreatment.typeOfSystemicTreatment" ] ;
fhir:short [ fhir:v "type of Systemic treatment" ] ;
fhir:definition [ fhir:v "Select the type of Systemic treatment administered. It is possible to directly select the single treatment as appropriate." ] ;
fhir:comment [ fhir:v "Chemotherapy; Immunotherapy; Target therapy;  Unknown\n\nChemotherapy - 4273629\nImmunotherapy - 40310107\nTarget therapy -  40488979\nUnknown - 4129922" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
      ( fhir:type [
fhir:code [ fhir:v "CodeableConcept"^^xsd:anyURI ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.intent" ] ;
      ( fhir:extension [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] ) ;
fhir:path [ fhir:v "SystemicTreatment.intent" ] ;
fhir:short [ fhir:v "Intent" ] ;
fhir:definition [ fhir:v "Clarifies the reasons why Other therapy is administered\n? Curative chemotherapy is chemotherapy administered with the goal of achieving a complete remission and preventing the recurrence of cancer. \n? Palliative chemotherapy refers to any chemotherapy administration that is not curative but administered simply to decrease tumor load and increase life expectancy. It has been defined also as ??treatment in circumstances where the impact of intervention is insufficient to result in major survival advantage, but does affect improvement in terms of tumor?related symptoms??" ] ;
fhir:comment [ fhir:v "Palliative; Curative; Unknwon\nPalliative - 4179711\nCurative - \nUnknown - 4129922" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
      ( fhir:type [
fhir:code [ fhir:v "CodeableConcept"^^xsd:anyURI ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.setting" ] ;
      ( fhir:extension [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] ) ;
fhir:path [ fhir:v "SystemicTreatment.setting" ] ;
fhir:short [ fhir:v "Setting" ] ;
fhir:definition [ fhir:v "clarifies the context / how the therapy was administered alone or in conjunction with other treatments\n? Neoadjuvant: treatment given as a first step to shrink a tumor before the main treatment, which is usually surgery, is given. Examples of neoadjuvant therapy include chemotherapy, radiation therapy, and hormone therapy. It is a type of induction therapy.\n? Adjuvant: additional cancer treatment given after the primary treatment to lower the risk that the cancer will come back. Adjuvant therapy may include chemotherapy, radiation therapy, hormone therapy, targeted therapy, or biological therapy.\n? Concomitant/concurrent: A treatment that is given at the same time as another (es. Chemotherapy + radiotherapy)." ] ;
fhir:comment [ fhir:v "Neo-adjuvant; Concomitant; Adjuvant; Other tretament alone;  Unknown;\nNeo-adjuvant - 44808409\nConcomitant - \n Adjuvant - 44804498\nOther tretament alone - \nUnknown - 4129922" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
      ( fhir:type [
fhir:code [ fhir:v "CodeableConcept"^^xsd:anyURI ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.computedTomographyInfo" ] ;
      ( fhir:extension [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] ) ;
fhir:path [ fhir:v "SystemicTreatment.computedTomographyInfo" ] ;
fhir:short [ fhir:v "Computed tomography info" ] ;
fhir:definition [ fhir:v "Information for computed tomography" ] ;
fhir:comment [ fhir:v "Pre-operative; Post-operative; Intra-operative (hypertermic intraperiotoneal chemotherapy HIPEC ); therapeutic (without surgery)\nPreoperative - 4119031\nPostoperative period - 4118656\nHyperthermic intraperitoneal chemotherapy - 3184898\nTherapeutic - 4133895" ] ;
fhir:min [ fhir:v "0"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
      ( fhir:type [
fhir:code [ fhir:v "CodeableConcept"^^xsd:anyURI ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.startDateSystemicTreatment" ] ;
      ( fhir:extension [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] ) ;
fhir:path [ fhir:v "SystemicTreatment.startDateSystemicTreatment" ] ;
fhir:short [ fhir:v "Start date Systemic treatment" ] ;
fhir:definition [ fhir:v "Specifies when Other treatment begins" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
      ( fhir:type [
fhir:code [ fhir:v "date"^^xsd:anyURI ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.endDateSystemicTreatment" ] ;
      ( fhir:extension [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] ) ;
fhir:path [ fhir:v "SystemicTreatment.endDateSystemicTreatment" ] ;
fhir:short [ fhir:v "End date Systemic treatment" ] ;
fhir:definition [ fhir:v "Specifies when Other treatment ends" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
      ( fhir:type [
fhir:code [ fhir:v "date"^^xsd:anyURI ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.numberOfCyclesAdministrations" ] ;
      ( fhir:extension [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] ) ;
fhir:path [ fhir:v "SystemicTreatment.numberOfCyclesAdministrations" ] ;
fhir:short [ fhir:v "Number of cycles/ administrations" ] ;
fhir:definition [ fhir:v "clarifies how many times the treatment was administered. A cycle of treatment is a period of treatment followed by a period of rest (no treatment). For example, treatment given for one week followed by three weeks of rest is one cycle of treatment. A cycle can be repeated multiple times." ] ;
fhir:min [ fhir:v "0"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
      ( fhir:type [
fhir:code [ fhir:v "decimal"^^xsd:anyURI ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.regimen" ] ;
      ( fhir:extension [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] ) ;
fhir:path [ fhir:v "SystemicTreatment.regimen" ] ;
fhir:short [ fhir:v "Regimen" ] ;
fhir:definition [ fhir:v "Regimen" ] ;
fhir:min [ fhir:v "0"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
      ( fhir:type [
fhir:code [ fhir:v "BackboneElement"^^xsd:anyURI ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.regimen.drugs1" ] ;
      ( fhir:extension [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] ) ;
fhir:path [ fhir:v "SystemicTreatment.regimen.drugs1" ] ;
fhir:short [ fhir:v "Drugs 1" ] ;
fhir:definition [ fhir:v "Drugs 1" ] ;
fhir:comment [ fhir:v "ATC list\nAthena vocabulary \nATC" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
      ( fhir:type [
fhir:code [ fhir:v "CodeableConcept"^^xsd:anyURI ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.regimen.drugs2" ] ;
      ( fhir:extension [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] ) ;
fhir:path [ fhir:v "SystemicTreatment.regimen.drugs2" ] ;
fhir:short [ fhir:v "Drugs 2" ] ;
fhir:definition [ fhir:v "Drugs 2" ] ;
fhir:comment [ fhir:v "ATC list\nAthena vocabulary \nATC" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
      ( fhir:type [
fhir:code [ fhir:v "CodeableConcept"^^xsd:anyURI ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.regimen.drugs3" ] ;
      ( fhir:extension [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] ) ;
fhir:path [ fhir:v "SystemicTreatment.regimen.drugs3" ] ;
fhir:short [ fhir:v "Drugs 3" ] ;
fhir:definition [ fhir:v "Drugs 3" ] ;
fhir:comment [ fhir:v "ATC list\nAthena vocabulary \nATC" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
      ( fhir:type [
fhir:code [ fhir:v "CodeableConcept"^^xsd:anyURI ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.regimen.startDateRegimenChanged" ] ;
      ( fhir:extension [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] ) ;
fhir:path [ fhir:v "SystemicTreatment.regimen.startDateRegimenChanged" ] ;
fhir:short [ fhir:v "Start date regimen changed" ] ;
fhir:definition [ fhir:v "specifies when the new Other treatment begins, if a combination please specify the start of the first drug" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
      ( fhir:type [
fhir:code [ fhir:v "date"^^xsd:anyURI ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.regimen.endDateRegimenChanged" ] ;
      ( fhir:extension [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] ) ;
fhir:path [ fhir:v "SystemicTreatment.regimen.endDateRegimenChanged" ] ;
fhir:short [ fhir:v "End date regimen changed" ] ;
fhir:definition [ fhir:v "specifies when the new  Other treatment ends,if a combination please specify the end of the last drug" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
      ( fhir:type [
fhir:code [ fhir:v "date"^^xsd:anyURI ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.reasonForEndOfTreatment" ] ;
      ( fhir:extension [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] ) ;
fhir:path [ fhir:v "SystemicTreatment.reasonForEndOfTreatment" ] ;
fhir:short [ fhir:v "Reason for end of treatment" ] ;
fhir:definition [ fhir:v "Clarifies the reasons why the treatment ended or was interrupted" ] ;
fhir:comment [ fhir:v "Completion; Toxicity; Comorbidity; Patient  intolerance; Patients decision; Death;  Unknown.\nCompletion - 4058777 \nToxicity - 438028\nComorbidity - 4162706 \nPatient  intolerance -  4105297\nPatients decision - \nDeath - 4306655\nUnknown - 4129922" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
      ( fhir:type [
fhir:code [ fhir:v "CodeableConcept"^^xsd:anyURI ]       ] )     ] [
fhir:id [ fhir:v "SystemicTreatment.treatmentResponse" ] ;
      ( fhir:extension [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] [
        ( fhir:extension [
fhir:url [ fhir:v "code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "SHALL:handle" ]         ] [
fhir:url [ fhir:v "actor"^^xsd:anyURI ] ;
fhir:value [
fhir:v "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"^^xsd:anyURI ;
fhir:link <http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc>           ]         ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/obligation"^^xsd:anyURI ]       ] ) ;
fhir:path [ fhir:v "SystemicTreatment.treatmentResponse" ] ;
fhir:short [ fhir:v "Treatment response (based on imaging alone; no recist or other criteria)" ] ;
fhir:definition [ fhir:v "Measures how well a cancer patient responds to treatment. RECIST criteria should not be applied. The definition of Complete response; Partial response; Stable disease; Progression, should be based on the clinical judgement based on imaging.  Only when setting=neoadiuvant or  palliative" ] ;
fhir:comment [ fhir:v "Complete response; Partial response; Stable disease; Progression; Unknown.\nComplete response - 4163135\nPartial response -  4161302\nStable disease - 4241442\nProgression - 4168352\nUnknown - 4129922" ] ;
fhir:min [ fhir:v "1"^^xsd:nonNegativeInteger ] ;
fhir:max [ fhir:v "1" ] ;
      ( fhir:type [
fhir:code [ fhir:v "CodeableConcept"^^xsd:anyURI ]       ] )     ] )
  ] . #