Order Catalog Implementation Guide
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Order Catalog Implementation Guide, published by HL7 International - Orders and Observations Work Group. This is not an authorized publication; it is the continuous build for version current). This version is based on the current content of https://github.com/HL7/fhir-order-catalog/ and changes regularly. See the Directory of published versions

: Clarithromycin oral antibacterial - JSON Representation

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{
  "resourceType" : "MedicationKnowledge",
  "id" : "example-drug-clarithromycin-25mg-granule-suspension",
  "meta" : {
    "profile" : [
      "http://hl7.org/fhir/uv/order-catalog/StructureDefinition/DrugKnowledge"
    ]
  },
  "language" : "en-US",
  "text" : {
    "status" : "extensions",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\" xml:lang=\"en-US\" lang=\"en-US\"><p><b>Generated Narrative: MedicationKnowledge</b><a name=\"example-drug-clarithromycin-25mg-granule-suspension\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource MedicationKnowledge &quot;example-drug-clarithromycin-25mg-granule-suspension&quot;  (Language &quot;en-US&quot;) </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-DrugKnowledge.html\">item in a catalog of drugs</a></p></div><p><b>Reference to a catalog</b>: <a href=\"Composition-example-medication-catalog-header.html\">Composition/example-medication-catalog-header</a></p><p><b>code</b>: Clarithromycin 25 mg/mL oral suspension <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOMED CT</a>#769316002)</span></p><p><b>intendedJurisdiction</b>: Healthyland <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>name</b>: CLARITHROMYCINE GENERIC-LAB 25 mg/ml, granules for oral suspension</p><p><b>productType</b>: Generic product <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><blockquote><p><b>indicationGuideline</b></p><h3>Indications</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"ClinicalUseDefinition-example-bacterial-pharyngitis-indication.html\">ClinicalUseDefinition/example-bacterial-pharyngitis-indication</a></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"ClinicalUseDefinition-example-acute-otitis-media-indication.html\">ClinicalUseDefinition/example-acute-otitis-media-indication</a></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"ClinicalUseDefinition-example-bacterial-sinusitis-indication.html\">ClinicalUseDefinition/example-bacterial-sinusitis-indication</a></td></tr></table><blockquote><p><b>dosingGuideline</b></p><h3>PatientCharacteristics</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Age <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#30525-0)</span></td><td>0.5-12 years</td></tr></table></blockquote></blockquote><blockquote><p><b>medicineClassification</b></p><p><b>type</b>: Anatomical Therapeutic Chemical (ATC) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>source</b>: <a href=\"https://www.whocc.no/atc/structure_and_principles/\">https://www.whocc.no/atc/structure_and_principles/</a></p><p><b>classification</b>: Clarithromycin <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.0.0/CodeSystem-v3-WC.html\">WHO ATC</a>#J01FA09)</span></p></blockquote><blockquote><p><b>medicineClassification</b></p><p><b>type</b>: SNOMED CT drug dispositions <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>source</b>: <a href=\"https://confluence.ihtsdotools.org/display/DOCEG/SNOMED+CT+Editorial+Guide+-+Pharmaceutical+and+Biologic+Product\">https://confluence.ihtsdotools.org/display/DOCEG/SNOMED+CT+Editorial+Guide+-+Pharmaceutical+and+Biologic+Product</a></p><p><b>classification</b>: Medicinal product acting as antibacterial agent <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOMED CT</a>#346325008)</span></p></blockquote><blockquote><p><b>packaging</b></p><h3>Costs</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>EffectiveDate</b></td><td><b>Type</b></td><td><b>Source</b></td><td><b>Cost[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>2021-02-01 --&gt; (ongoing)</td><td>public price <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>Healthyland Drug Administration</td><td><span title=\"Euro\">€5.18</span> (EUR)</td></tr><tr><td style=\"display: none\">*</td><td>2020-09-30 --&gt; 2021-01-31</td><td>public price <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>Healthyland Drug Administration</td><td><span title=\"Euro\">€5.20</span> (EUR)</td></tr><tr><td style=\"display: none\">*</td><td>2010-03-01 --&gt; (ongoing)</td><td>manufacturers' cost <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>Healthyland Drug Administration</td><td><span title=\"Euro\">€4.40</span> (EUR)</td></tr></table><p><b>packagedProduct</b>: <a href=\"PackagedProductDefinition-example-drug-package-clarithromycin.html\">PackagedProductDefinition/example-drug-package-clarithromycin</a> &quot;Package for CLARITHROMYCINE GENERIC-LAB 25 mg/ml, granules for oral suspension in 100 ml HDPE bottle&quot;</p></blockquote><p><b>clinicalUseIssue</b>: <a href=\"ClinicalUseDefinition-example-allergy-contraindication.html\">ClinicalUseDefinition/example-allergy-contraindication</a></p><blockquote><p><b>definitional</b></p><p><b>doseForm</b>: Granules for oral suspension <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOMED CT</a>#385029002; standardterms.edqm.eu#10113000)</span></p><p><b>intendedRoute</b>: Oral route <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOMED CT</a>#26643006)</span></p><blockquote><p><b>ingredient</b></p><h3>Items</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Concept</b></td></tr><tr><td style=\"display: none\">*</td><td>Clarithromycin <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOMED CT</a>#387487009)</span></td></tr></table><p><b>type</b>: active ingredient - basis of strength <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.0.0/CodeSystem-v3-RoleClass.html\">RoleClass</a>#ACTIB)</span></p><p><b>strength</b>: 25 milligram<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM code mg = 'mg')</span>/1 milliliter<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM code mL = 'mL')</span></p></blockquote><blockquote><p><b>ingredient</b></p><h3>Items</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Concept</b></td></tr><tr><td style=\"display: none\">*</td><td>Sucrose <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOMED CT</a>#11320009)</span></td></tr></table><p><b>type</b>: inactive ingredient <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.0.0/CodeSystem-v3-RoleClass.html\">RoleClass</a>#IACT)</span></p></blockquote></blockquote></div>"
  },
  "extension" : [
    {
      "url" : "http://hl7.org/fhir/uv/order-catalog/StructureDefinition/CatalogReference",
      "valueReference" : {
        "reference" : "Composition/example-medication-catalog-header"
      }
    }
  ],
  "code" : {
    "coding" : [
      {
        "system" : "http://snomed.info/sct",
        "code" : "769316002",
        "display" : "Clarithromycin 25 mg/mL oral suspension"
      }
    ]
  },
  "intendedJurisdiction" : [
    {
      "text" : "Healthyland"
    }
  ],
  "name" : [
    "CLARITHROMYCINE GENERIC-LAB 25 mg/ml, granules for oral suspension"
  ],
  "productType" : [
    {
      "text" : "Generic product"
    }
  ],
  "indicationGuideline" : [
    {
      "indication" : [
        {
          "reference" : {
            "reference" : "ClinicalUseDefinition/example-bacterial-pharyngitis-indication"
          }
        },
        {
          "reference" : {
            "reference" : "ClinicalUseDefinition/example-acute-otitis-media-indication"
          }
        },
        {
          "reference" : {
            "reference" : "ClinicalUseDefinition/example-bacterial-sinusitis-indication"
          }
        }
      ],
      "dosingGuideline" : [
        {
          "patientCharacteristic" : [
            {
              "type" : {
                "coding" : [
                  {
                    "system" : "http://loinc.org",
                    "code" : "30525-0",
                    "display" : "Age"
                  }
                ]
              },
              "valueRange" : {
                "low" : {
                  "value" : 0.5,
                  "unit" : "years",
                  "system" : "http://unitsofmeasure.org",
                  "code" : "a"
                },
                "high" : {
                  "value" : 12,
                  "unit" : "years",
                  "system" : "http://unitsofmeasure.org",
                  "code" : "a"
                }
              }
            }
          ]
        }
      ]
    }
  ],
  "medicineClassification" : [
    {
      "type" : {
        "text" : "Anatomical Therapeutic Chemical (ATC)"
      },
      "sourceUri" : "https://www.whocc.no/atc/structure_and_principles/",
      "classification" : [
        {
          "coding" : [
            {
              "system" : "http://www.whocc.no/atc",
              "code" : "J01FA09",
              "display" : "Clarithromycin"
            }
          ]
        }
      ]
    },
    {
      "type" : {
        "text" : "SNOMED CT drug dispositions"
      },
      "sourceUri" : "https://confluence.ihtsdotools.org/display/DOCEG/SNOMED+CT+Editorial+Guide+-+Pharmaceutical+and+Biologic+Product",
      "classification" : [
        {
          "coding" : [
            {
              "system" : "http://snomed.info/sct",
              "code" : "346325008",
              "display" : "Medicinal product acting as antibacterial agent"
            }
          ]
        }
      ]
    }
  ],
  "packaging" : [
    {
      "cost" : [
        {
          "effectiveDate" : [
            {
              "start" : "2021-02-01"
            }
          ],
          "type" : {
            "text" : "public price"
          },
          "source" : "Healthyland Drug Administration",
          "costMoney" : {
            "value" : 5.18,
            "currency" : "EUR"
          }
        },
        {
          "effectiveDate" : [
            {
              "start" : "2020-09-30",
              "end" : "2021-01-31"
            }
          ],
          "type" : {
            "text" : "public price"
          },
          "source" : "Healthyland Drug Administration",
          "costMoney" : {
            "value" : 5.2,
            "currency" : "EUR"
          }
        },
        {
          "effectiveDate" : [
            {
              "start" : "2010-03-01"
            }
          ],
          "type" : {
            "text" : "manufacturers' cost"
          },
          "source" : "Healthyland Drug Administration",
          "costMoney" : {
            "value" : 4.4,
            "currency" : "EUR"
          }
        }
      ],
      "packagedProduct" : {
        "reference" : "PackagedProductDefinition/example-drug-package-clarithromycin"
      }
    }
  ],
  "clinicalUseIssue" : [
    {
      "reference" : "ClinicalUseDefinition/example-allergy-contraindication"
    }
  ],
  "definitional" : {
    "doseForm" : {
      "coding" : [
        {
          "system" : "http://snomed.info/sct",
          "code" : "385029002",
          "display" : "Granules for oral suspension"
        },
        {
          "system" : "http://standardterms.edqm.eu",
          "code" : "10113000",
          "display" : "Granules for oral suspension"
        }
      ]
    },
    "intendedRoute" : [
      {
        "coding" : [
          {
            "system" : "http://snomed.info/sct",
            "code" : "26643006",
            "display" : "Oral route"
          }
        ]
      }
    ],
    "ingredient" : [
      {
        "item" : {
          "concept" : {
            "coding" : [
              {
                "system" : "http://snomed.info/sct",
                "code" : "387487009",
                "display" : "Clarithromycin"
              }
            ]
          }
        },
        "type" : {
          "coding" : [
            {
              "system" : "http://terminology.hl7.org/CodeSystem/v3-RoleClass",
              "code" : "ACTIB",
              "display" : "active ingredient - basis of strength"
            }
          ]
        },
        "strengthRatio" : {
          "numerator" : {
            "value" : 25,
            "unit" : "milligram",
            "system" : "http://unitsofmeasure.org",
            "code" : "mg"
          },
          "denominator" : {
            "value" : 1,
            "unit" : "milliliter",
            "system" : "http://unitsofmeasure.org",
            "code" : "mL"
          }
        }
      },
      {
        "item" : {
          "concept" : {
            "coding" : [
              {
                "system" : "http://snomed.info/sct",
                "code" : "11320009",
                "display" : "Sucrose"
              }
            ]
          }
        },
        "type" : {
          "coding" : [
            {
              "system" : "http://terminology.hl7.org/CodeSystem/v3-RoleClass",
              "code" : "IACT",
              "display" : "inactive ingredient"
            }
          ]
        }
      }
    ]
  }
}