Clinical Practice Guidelines (CPG) on EBMonFHIR
1.0.2 - ci-build
Clinical Practice Guidelines (CPG) on EBMonFHIR
1.0.2 - ci-build
Clinical Practice Guidelines (CPG) on EBMonFHIR, published by Universitätsmedizin Greifswald. This guide is not an authorized publication; it is the continuous build for version 1.0.2 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/CEOsys/cpg-on-ebm-on-fhir/ and changes regularly. See the Directory of published versions
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"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Composition_COVID19IntensiveCareTreatmentGuideline\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Composition COVID19IntensiveCareTreatmentGuideline</b></p><a name=\"COVID19IntensiveCareTreatmentGuideline\"> </a><a name=\"hcCOVID19IntensiveCareTreatmentGuideline\"> </a><a name=\"COVID19IntensiveCareTreatmentGuideline-en-US\"> </a><p><b>identifier</b>: Resource identifier/113-001</p><p><b>version</b>: 7.0</p><p><b>status</b>: Final</p><p><b>type</b>: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system clinical-practice-guideline}, {https://data.cochrane.org/concepts/ e07eN1w1Rwswg4}\">Guidelines</span></p><p><b>category</b>: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-guideline-stage-classification S3}\">Evidence- and consensus-based guideline</span></p><p><b>date</b>: 2022-03-01</p><p><b>author</b>: <a href=\"Organization-AWMFOrganization.html\">Organization Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF) e.V.</a></p><p><b>title</b>: Empfehlungen zur stationären Therapie von Patienten mit COVID-19 - Living Guideline</p><h3>RelatesTos</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>ResourceReference</b></td></tr><tr><td style=\"display: none\">*</td><td>Citation</td><td><a href=\"Citation-COVID19IntensiveCareTreatmentGuidelineCitation.html\">Citation COVID19_Intensive_Care_Treatment_Guideline</a></td></tr></table></div>"
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"focus" : {
🔗 "reference" : "PlanDefinition/COVID19VentilatedPatientsDexamethasoneApplicationPlan"
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"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><strong>Systemische Steroide:</strong> Bei Patienten mit COVID-19- und Sauerstoff-Bedarf (Niedrigfluss-Sauerstoff-Insufflation, High-Flow Nasal Cannula, Nichtinvasive Beatmung/CPAP, invasive Beatmung) soll eine Therapie mit systemischen Kortikosteroiden erfolgen. Die Therapie sollte mit 6 mg Dexamethason p.o. oder i.v. über zehn Tage erfolgen.</div>"
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🔗 "reference" : "PlanDefinition/COVID19NonVentilatedPatientsDexamethasoneApplicationPlan"
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"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><strong>Systemische Steroide:</strong> Bei Patienten mit moderater Erkrankung (hospitalisiert ohne Notwendigkeit von Niedrigfluss-Sauerstoff-Insufflation) soll keine Therapie mit systemischen Kortikosteroiden erfolgen.</div>"
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"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Citation_COVID19IntensiveCareTreatmentGuidelineCitation\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Citation COVID19IntensiveCareTreatmentGuidelineCitation</b></p><a name=\"COVID19IntensiveCareTreatmentGuidelineCitation\"> </a><a name=\"hcCOVID19IntensiveCareTreatmentGuidelineCitation\"> </a><a name=\"COVID19IntensiveCareTreatmentGuidelineCitation-en-US\"> </a><p><b>name</b>: COVID19_Intensive_Care_Treatment_Guideline</p><p><b>status</b>: Active</p><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: <code>https://www.awmf.org/</code>/113-001</p><h3>Versions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Value</b></td></tr><tr><td style=\"display: none\">*</td><td>7.0</td></tr></table><p><b>currentState</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-status-type active}\">Active</span></p><h3>Titles</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td><div><p>S3-Leitlinie Stationäre Therapie von COVID-19 Patienten</p>\n</div></td></tr></table><h3>WebLocations</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://www.awmf.org/leitlinien/detail/ll/113-001.html\">https://www.awmf.org/leitlinien/detail/ll/113-001.html</a></td></tr></table><h3>Classifications</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type publication-type}\">Publication Type</span></td><td><span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system clinical-practice-guideline}\">Clinical practice guideline</span></td></tr></table></blockquote></div>"
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"fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation",
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"resourceType" : "PlanDefinition",
"id" : "COVID19DexamethasoneApplication",
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"status" : "extensions",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"PlanDefinition_COVID19DexamethasoneApplication\"> </a><p class=\"res-header-id\"><b>Generated Narrative: PlanDefinition COVID19DexamethasoneApplication</b></p><a name=\"COVID19DexamethasoneApplication\"> </a><a name=\"hcCOVID19DexamethasoneApplication\"> </a><a name=\"COVID19DexamethasoneApplication-en-US\"> </a><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><blockquote><p><b>Action Combination Method</b></p><ul><li>method: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method one-or-more}\">One or More</span></li></ul></blockquote><p><b>url</b>: <a href=\"PlanDefinition-COVID19DexamethasoneApplication.html\">PlanDefinition Dexamethasone Application</a></p><p><b>version</b>: 4.0</p><p><b>name</b>: Dexamethasone_Application</p><p><b>title</b>: Dexamethasone Application</p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/plan-definition-type workflow-definition}\">Workflow Definition</span></p><p><b>status</b>: Active</p><p><b>experimental</b>: true</p><p><b>subject</b>: <a href=\"EvidenceVariable-PopulationCOVID19Ventilated.html\">Population_COVID19_Ventilated</a></p><p><b>date</b>: 2021-12-12</p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: </p><div><p>Application of Dexamethasone for ventilated patients only</p>\n</div><h3>RelatedArtifacts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td><td><b>ResourceReference</b></td></tr><tr><td style=\"display: none\">*</td><td>Justification</td><td><span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system recommendation-rating}\">Recommendation rating</span></td><td><a href=\"ArtifactAssessment-DexamethasoneRecommendationJustification.html\">ArtifactAssessment: extension = v4.0,active; date = 2020-01-03; artifact[x] = ->PlanDefinition Dexamethasone Application in ventilated COVID-19 patients</a></td></tr><tr><td style=\"display: none\">*</td><td>Citation</td><td><span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system guideline-recommendation}\">Clinical practice guideline recommendation</span></td><td><a href=\"Citation-DexamethasoneRecommendationCitation.html\">Citation DexamethasoneRecommendationCitation</a></td></tr><tr><td style=\"display: none\">*</td><td>Citation</td><td><span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system clinical-practice-guideline}\">Clinical practice guideline</span></td><td><a href=\"Citation-COVID19IntensiveCareTreatmentGuidelineCitation.html\">Citation COVID19_Intensive_Care_Treatment_Guideline</a></td></tr></table><blockquote><p><b>action</b></p><p><b>title</b>: Dexamethasone Application</p><p><b>description</b>: </p><div><p>Application of Dexamethasone: 6 mg once per day for 10 days p.o. or i.v. for ventilated COVID-19 patients</p>\n</div><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/cpg/CodeSystem/cpg-common-process guideline-based-care}\">Guideline-based Care</span></p><p><b>definition</b>: <a href=\"PlanDefinition-COVID19VentilatedPatientsDexamethasoneApplicationPlan.html\">Dexamethasone Application in ventilated COVID-19 patients</a></p></blockquote><blockquote><p><b>action</b></p><p><b>title</b>: No Dexamethasone Application</p><p><b>description</b>: </p><div><p>No Dexamethasone Application for non-ventilated COVID-19 patients</p>\n</div><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/cpg/CodeSystem/cpg-common-process guideline-based-care}\">Guideline-based Care</span></p><p><b>definition</b>: <a href=\"PlanDefinition-COVID19NonVentilatedPatientsDexamethasoneApplicationPlan.html\">No Dexamethasone Application for non-ventilated COVID-19 patients</a></p></blockquote></div>"
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🔗 "reference" : "ArtifactAssessment/DexamethasoneRecommendationJustification"
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"title" : "Dexamethasone Application",
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"code" : {
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{
"title" : "No Dexamethasone Application",
"description" : "No Dexamethasone Application for non-ventilated COVID-19 patients",
"code" : {
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"code" : "guideline-based-care"
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"resource" : {
"resourceType" : "PlanDefinition",
"id" : "COVID19VentilatedPatientsDexamethasoneApplicationPlan",
"meta" : {
"profile" : [
🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-plan"
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"text" : {
"status" : "extensions",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"PlanDefinition_COVID19VentilatedPatientsDexamethasoneApplicationPlan\"> </a><p class=\"res-header-id\"><b>Generated Narrative: PlanDefinition COVID19VentilatedPatientsDexamethasoneApplicationPlan</b></p><a name=\"COVID19VentilatedPatientsDexamethasoneApplicationPlan\"> </a><a name=\"hcCOVID19VentilatedPatientsDexamethasoneApplicationPlan\"> </a><a name=\"COVID19VentilatedPatientsDexamethasoneApplicationPlan-en-US\"> </a><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><p><b>partOf</b>: <a href=\"PlanDefinition-COVID19DexamethasoneApplication.html\">Dexamethasone Application</a></p><blockquote><p><b>Action Combination Method</b></p><ul><li>method: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method exactly}\">Exactly</span></li><li>threshold: 1</li></ul></blockquote><p><b>url</b>: <a href=\"PlanDefinition-COVID19VentilatedPatientsDexamethasoneApplicationPlan.html\">PlanDefinition Dexamethasone Application in ventilated COVID-19 patients</a></p><p><b>version</b>: 4.0</p><p><b>name</b>: Dexamethasone_Application</p><p><b>title</b>: Dexamethasone Application in ventilated COVID-19 patients</p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/plan-definition-type eca-rule}\">ECA Rule</span></p><p><b>status</b>: Active</p><p><b>experimental</b>: true</p><p><b>subject</b>: <a href=\"EvidenceVariable-PopulationCOVID19Ventilated.html\">Population_COVID19_Ventilated</a></p><p><b>date</b>: 2021-12-12</p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: </p><div><p>Application of Dexamethasone: 6 mg once per day for 10 days p.o. or i.v. for ventilated COVID-19 patients</p>\n</div><blockquote><p><b>action</b></p><p><b>code</b>: <span title=\"Codes:{http://snomed.info/sct 432102000}\">Administration of substance (procedure)</span></p><p><b>definition</b>: <a href=\"Bundle-COVID19IntensiveCareTreatmentGuidelineBundle.html\">DexamethasoneApplicationActionOral</a></p></blockquote><blockquote><p><b>action</b></p><p><b>code</b>: <span title=\"Codes:{http://snomed.info/sct 432102000}\">Administration of substance (procedure)</span></p><p><b>definition</b>: <a href=\"Bundle-COVID19IntensiveCareTreatmentGuidelineBundle.html\">DexamethasoneApplicationActionIntravenous</a></p></blockquote></div>"
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"title" : "Dexamethasone Application in ventilated COVID-19 patients",
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"status" : "active",
"experimental" : true,
"subjectCanonical" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/population/Population_COVID19_Ventilated",
"date" : "2021-12-12",
"publisher" : "CPGonEBMonFHIR",
"description" : "Application of Dexamethasone: 6 mg once per day for 10 days p.o. or i.v. for ventilated COVID-19 patients",
"action" : [
{
"code" : {
"coding" : [
{
"system" : "http://snomed.info/sct",
"code" : "432102000",
"display" : "Administration of substance (procedure)"
}
]
},
"definitionCanonical" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/dexamethasone-application-oral"
},
{
"code" : {
"coding" : [
{
"system" : "http://snomed.info/sct",
"code" : "432102000",
"display" : "Administration of substance (procedure)"
}
]
},
"definitionCanonical" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/dexamethasone-application-intravenous"
}
]
}
},
{
"fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-plan-non-ventilated-patients",
"resource" : {
"resourceType" : "PlanDefinition",
"id" : "COVID19NonVentilatedPatientsDexamethasoneApplicationPlan",
"meta" : {
"profile" : [
🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-plan"
]
},
"text" : {
"status" : "extensions",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"PlanDefinition_COVID19NonVentilatedPatientsDexamethasoneApplicationPlan\"> </a><p class=\"res-header-id\"><b>Generated Narrative: PlanDefinition COVID19NonVentilatedPatientsDexamethasoneApplicationPlan</b></p><a name=\"COVID19NonVentilatedPatientsDexamethasoneApplicationPlan\"> </a><a name=\"hcCOVID19NonVentilatedPatientsDexamethasoneApplicationPlan\"> </a><a name=\"COVID19NonVentilatedPatientsDexamethasoneApplicationPlan-en-US\"> </a><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><p><b>partOf</b>: <a href=\"PlanDefinition-COVID19DexamethasoneApplication.html\">Dexamethasone Application</a></p><blockquote><p><b>Action Combination Method</b></p><ul><li>method: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method exactly}\">Exactly</span></li><li>threshold: 1</li></ul></blockquote><p><b>url</b>: <a href=\"PlanDefinition-COVID19NonVentilatedPatientsDexamethasoneApplicationPlan.html\">PlanDefinition No Dexamethasone Application for non-ventilated COVID-19 patients</a></p><p><b>version</b>: 4.0</p><p><b>name</b>: No_Dexamethasone_Application</p><p><b>title</b>: No Dexamethasone Application for non-ventilated COVID-19 patients</p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/plan-definition-type eca-rule}\">ECA Rule</span></p><p><b>status</b>: Active</p><p><b>experimental</b>: true</p><p><b>subject</b>: <a href=\"EvidenceVariable-PopulationCOVID19NonVentilated.html\">Population_COVID19_NonVentilated</a></p><p><b>date</b>: 2021-12-12</p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: </p><div><p>No Dexamethasone Application for non-ventilated COVID19 patients</p>\n</div><h3>Actions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 432102000}\">Administration of substance (procedure)</span></td><td><a href=\"Bundle-COVID19IntensiveCareTreatmentGuidelineBundle.html\">NoDexamethasoneApplicationActivity</a></td></tr></table></div>"
},
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability",
"valueCode" : "computable"
},
{
"url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel",
"valueCode" : "structured"
},
{
"url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-partOf",
"valueCanonical" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-dexamethasone-recommendation"
},
{
"extension" : [
{
"url" : "method",
"valueCodeableConcept" : {
"coding" : [
{
"system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method",
"code" : "exactly"
}
]
}
},
{
"url" : "threshold",
"valuePositiveInt" : 1
}
],
"url" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ext-action-combination-method"
}
],
"url" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-non-ventilated-patients-no-dexamethasone-application-plan",
"version" : "4.0",
"name" : "No_Dexamethasone_Application",
"title" : "No Dexamethasone Application for non-ventilated COVID-19 patients",
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/plan-definition-type",
"code" : "eca-rule"
}
]
},
"status" : "active",
"experimental" : true,
"subjectCanonical" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/population/Population_COVID19_NonVentilated",
"date" : "2021-12-12",
"publisher" : "CPGonEBMonFHIR",
"description" : "No Dexamethasone Application for non-ventilated COVID19 patients",
"action" : [
{
"code" : {
"coding" : [
{
"system" : "http://snomed.info/sct",
"code" : "432102000",
"display" : "Administration of substance (procedure)"
}
]
},
"definitionCanonical" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/no-dexamethasone-application"
}
]
}
},
{
"fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-action-oral",
"resource" : {
"resourceType" : "ActivityDefinition",
"id" : "DexamethasoneApplicationActionOral",
"meta" : {
"profile" : [
🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/drug-administration-action"
]
},
"text" : {
"status" : "extensions",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"ActivityDefinition_DexamethasoneApplicationActionOral\"> </a><p class=\"res-header-id\"><b>Generated Narrative: ActivityDefinition DexamethasoneApplicationActionOral</b></p><a name=\"DexamethasoneApplicationActionOral\"> </a><a name=\"hcDexamethasoneApplicationActionOral\"> </a><a name=\"DexamethasoneApplicationActionOral-en-US\"> </a><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><p><b>url</b>: <a href=\"ActivityDefinition-DexamethasoneApplicationActionOral.html\">ActivityDefinition DexamethasoneApplicationActionOral</a></p><p><b>version</b>: 1.0</p><p><b>name</b>: DexamethasoneApplicationActionOral</p><p><b>status</b>: Active</p><p><b>experimental</b>: true</p><p><b>subject</b>: <span title=\"Codes:{http://hl7.org/fhir/fhir-types Patient}\">Patient</span></p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: </p><div><p>Application of Dexamethasone: 6 mg once per day for 10 days (oral route)</p>\n</div><p><b>kind</b>: MedicationRequest</p><p><b>code</b>: <span title=\"Codes:{http://snomed.info/sct 432102000}\">Administration of substance (procedure)</span></p><p><b>product</b>: <span title=\"Codes:{http://snomed.info/sct 372584003}, {http://fhir.de/CodeSystem/bfarm/atc C05AA09}\">Dexamethasone (substance)</span></p><blockquote><p><b>dosage</b></p><p><b>timing</b>: Count 10 times, Duration 10days , Once per 1 days</p><p><b>route</b>: <span title=\"Codes:{http://snomed.info/sct 26643006}\">Oral route</span></p><h3>DoseAndRates</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Dose[x]</b></td><td><b>Rate[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>6 mg<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM codemg = 'mg')</span></td><td>1 /d<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM code/d = '/d')</span></td></tr></table></blockquote></div>"
},
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability",
"valueCode" : "computable"
},
{
"url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel",
"valueCode" : "structured"
}
],
"url" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/dexamethasone-application-oral",
"version" : "1.0",
"name" : "DexamethasoneApplicationActionOral",
"status" : "active",
"experimental" : true,
"subjectCodeableConcept" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/fhir-types",
"code" : "Patient"
}
]
},
"publisher" : "CPGonEBMonFHIR",
"description" : "Application of Dexamethasone: 6 mg once per day for 10 days (oral route)",
"kind" : "MedicationRequest",
"code" : {
"coding" : [
{
"system" : "http://snomed.info/sct",
"code" : "432102000",
"display" : "Administration of substance (procedure)"
}
]
},
"productCodeableConcept" : {
"coding" : [
{
"system" : "http://snomed.info/sct",
"code" : "372584003",
"display" : "Dexamethasone (substance)"
},
{
"system" : "http://fhir.de/CodeSystem/bfarm/atc",
"code" : "C05AA09",
"display" : "Dexamethason"
}
]
},
"dosage" : [
{
"timing" : {
"repeat" : {
"count" : 10,
"duration" : 10,
"durationUnit" : "d",
"frequency" : 1,
"period" : 1,
"periodUnit" : "d"
}
},
"route" : {
"coding" : [
{
"system" : "http://snomed.info/sct",
"code" : "26643006",
"display" : "Oral route"
}
]
},
"doseAndRate" : [
{
"doseQuantity" : {
"value" : 6,
"unit" : "mg",
"system" : "http://unitsofmeasure.org",
"code" : "mg"
},
"rateQuantity" : {
"value" : 1,
"unit" : "/d",
"system" : "http://unitsofmeasure.org",
"code" : "/d"
}
}
]
}
]
}
},
{
"fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-action-intravenous",
"resource" : {
"resourceType" : "ActivityDefinition",
"id" : "DexamethasoneApplicationActionIntravenous",
"meta" : {
"profile" : [
🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/drug-administration-action"
]
},
"text" : {
"status" : "extensions",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"ActivityDefinition_DexamethasoneApplicationActionIntravenous\"> </a><p class=\"res-header-id\"><b>Generated Narrative: ActivityDefinition DexamethasoneApplicationActionIntravenous</b></p><a name=\"DexamethasoneApplicationActionIntravenous\"> </a><a name=\"hcDexamethasoneApplicationActionIntravenous\"> </a><a name=\"DexamethasoneApplicationActionIntravenous-en-US\"> </a><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><p><b>url</b>: <a href=\"ActivityDefinition-DexamethasoneApplicationActionIntravenous.html\">ActivityDefinition DexamethasoneApplicationActionIntravenous</a></p><p><b>version</b>: 1.0</p><p><b>name</b>: DexamethasoneApplicationActionIntravenous</p><p><b>status</b>: Active</p><p><b>experimental</b>: true</p><p><b>subject</b>: <span title=\"Codes:{http://hl7.org/fhir/fhir-types Patient}\">Patient</span></p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: </p><div><p>Application of Dexamethasone: 6 mg once per day for 10 days (intravenous route)</p>\n</div><p><b>kind</b>: MedicationRequest</p><p><b>code</b>: <span title=\"Codes:{http://snomed.info/sct 432102000}\">Administration of substance (procedure)</span></p><p><b>product</b>: <span title=\"Codes:{http://snomed.info/sct 372584003}, {http://fhir.de/CodeSystem/bfarm/atc C05AA09}\">Dexamethasone (substance)</span></p><blockquote><p><b>dosage</b></p><p><b>timing</b>: Count 10 times, Duration 10days , Once per 1 days</p><p><b>route</b>: <span title=\"Codes:{http://snomed.info/sct 47625008}\">Intravenous route</span></p><h3>DoseAndRates</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Dose[x]</b></td><td><b>Rate[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>6 mg<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM codemg = 'mg')</span></td><td>1 /d<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM code/d = '/d')</span></td></tr></table></blockquote></div>"
},
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability",
"valueCode" : "computable"
},
{
"url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel",
"valueCode" : "structured"
}
],
"url" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/dexamethasone-application-intravenous",
"version" : "1.0",
"name" : "DexamethasoneApplicationActionIntravenous",
"status" : "active",
"experimental" : true,
"subjectCodeableConcept" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/fhir-types",
"code" : "Patient"
}
]
},
"publisher" : "CPGonEBMonFHIR",
"description" : "Application of Dexamethasone: 6 mg once per day for 10 days (intravenous route)",
"kind" : "MedicationRequest",
"code" : {
"coding" : [
{
"system" : "http://snomed.info/sct",
"code" : "432102000",
"display" : "Administration of substance (procedure)"
}
]
},
"productCodeableConcept" : {
"coding" : [
{
"system" : "http://snomed.info/sct",
"code" : "372584003",
"display" : "Dexamethasone (substance)"
},
{
"system" : "http://fhir.de/CodeSystem/bfarm/atc",
"code" : "C05AA09",
"display" : "Dexamethason"
}
]
},
"dosage" : [
{
"timing" : {
"repeat" : {
"count" : 10,
"duration" : 10,
"durationUnit" : "d",
"frequency" : 1,
"period" : 1,
"periodUnit" : "d"
}
},
"route" : {
"coding" : [
{
"system" : "http://snomed.info/sct",
"code" : "47625008",
"display" : "Intravenous route"
}
]
},
"doseAndRate" : [
{
"doseQuantity" : {
"value" : 6,
"unit" : "mg",
"system" : "http://unitsofmeasure.org",
"code" : "mg"
},
"rateQuantity" : {
"value" : 1,
"unit" : "/d",
"system" : "http://unitsofmeasure.org",
"code" : "/d"
}
}
]
}
]
}
},
{
"fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-action-no-application",
"resource" : {
"resourceType" : "ActivityDefinition",
"id" : "NoDexamethasoneApplication",
"meta" : {
"profile" : [
🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/drug-administration-action"
]
},
"text" : {
"status" : "extensions",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"ActivityDefinition_NoDexamethasoneApplication\"> </a><p class=\"res-header-id\"><b>Generated Narrative: ActivityDefinition NoDexamethasoneApplication</b></p><a name=\"NoDexamethasoneApplication\"> </a><a name=\"hcNoDexamethasoneApplication\"> </a><a name=\"NoDexamethasoneApplication-en-US\"> </a><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><p><b>url</b>: <a href=\"ActivityDefinition-NoDexamethasoneApplication.html\">ActivityDefinition NoDexamethasoneApplicationActivity</a></p><p><b>version</b>: 1.0</p><p><b>name</b>: NoDexamethasoneApplicationActivity</p><p><b>status</b>: Active</p><p><b>experimental</b>: true</p><p><b>subject</b>: <span title=\"Codes:{http://hl7.org/fhir/fhir-types Patient}\">Patient</span></p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: </p><div><p>No Application of Dexamethasone</p>\n</div><p><b>kind</b>: MedicationRequest</p><p><b>code</b>: <span title=\"Codes:{http://snomed.info/sct 432102000}\">Administration of substance (procedure)</span></p><p><b>doNotPerform</b>: true</p><p><b>product</b>: <span title=\"Codes:{http://snomed.info/sct 372584003}, {http://fhir.de/CodeSystem/bfarm/atc C05AA09}\">Dexamethasone (substance)</span></p></div>"
},
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability",
"valueCode" : "computable"
},
{
"url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel",
"valueCode" : "structured"
}
],
"url" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/no-dexamethasone-application",
"version" : "1.0",
"name" : "NoDexamethasoneApplicationActivity",
"status" : "active",
"experimental" : true,
"subjectCodeableConcept" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/fhir-types",
"code" : "Patient"
}
]
},
"publisher" : "CPGonEBMonFHIR",
"description" : "No Application of Dexamethasone",
"kind" : "MedicationRequest",
"code" : {
"coding" : [
{
"system" : "http://snomed.info/sct",
"code" : "432102000",
"display" : "Administration of substance (procedure)"
}
]
},
"doNotPerform" : true,
"productCodeableConcept" : {
"coding" : [
{
"system" : "http://snomed.info/sct",
"code" : "372584003",
"display" : "Dexamethasone (substance)"
},
{
"system" : "http://fhir.de/CodeSystem/bfarm/atc",
"code" : "C05AA09",
"display" : "Dexamethason"
}
]
}
}
},
{
"fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-citation",
"resource" : {
"resourceType" : "Citation",
"id" : "DexamethasoneRecommendationCitation",
"meta" : {
"profile" : [
🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-citation"
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Citation_DexamethasoneRecommendationCitation\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Citation DexamethasoneRecommendationCitation</b></p><a name=\"DexamethasoneRecommendationCitation\"> </a><a name=\"hcDexamethasoneRecommendationCitation\"> </a><a name=\"DexamethasoneRecommendationCitation-en-US\"> </a><p><b>name</b>: DexamethasoneRecommendationCitation</p><p><b>status</b>: Active</p><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: <code>https://api.magicapp.org/api/v1/recommendations</code>/98398</p><h3>Versions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Value</b></td></tr><tr><td style=\"display: none\">*</td><td>v4.0</td></tr></table><p><b>currentState</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-status-type active}\">Active</span></p><h3>Titles</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td><div><p>Steroide</p>\n</div></td></tr></table><h3>Classifications</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type publication-type}\">Publication Type</span></td><td><span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system guideline-recommendation}\">Clinical practice guideline recommendation</span></td></tr></table></blockquote></div>"
},
"name" : "DexamethasoneRecommendationCitation",
"status" : "active",
"citedArtifact" : {
"identifier" : [
{
"system" : "https://api.magicapp.org/api/v1/recommendations",
"value" : "98398"
}
],
"version" : {
"value" : "v4.0"
},
"currentState" : [
{
"coding" : [
{
"system" : "http://hl7.org/fhir/cited-artifact-status-type",
"code" : "active",
"display" : "Active"
}
]
}
],
"title" : [
{
"text" : "Steroide"
}
],
"classification" : [
{
"type" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/cited-artifact-classification-type",
"code" : "publication-type",
"display" : "Publication Type"
}
]
},
"classifier" : [
{
"coding" : [
{
"system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
"code" : "guideline-recommendation",
"display" : "Clinical practice guideline recommendation"
}
]
}
]
}
]
}
}
},
{
"fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/evidence-variable-ventilated",
"resource" : {
"resourceType" : "EvidenceVariable",
"id" : "PopulationCOVID19Ventilated",
"meta" : {
"profile" : [
🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-eligibility-criteria"
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"EvidenceVariable_PopulationCOVID19Ventilated\"> </a><p class=\"res-header-id\"><b>Generated Narrative: EvidenceVariable PopulationCOVID19Ventilated</b></p><a name=\"PopulationCOVID19Ventilated\"> </a><a name=\"hcPopulationCOVID19Ventilated\"> </a><a name=\"PopulationCOVID19Ventilated-en-US\"> </a><p><b>url</b>: <a href=\"EvidenceVariable-PopulationCOVID19Ventilated.html\">EvidenceVariable Population_COVID19_Ventilated</a></p><p><b>identifier</b>: <code>https://www.ceosys.de</code>/Ventilated</p><p><b>name</b>: Population_COVID19_Ventilated</p><p><b>status</b>: Active</p><p><b>description</b>: </p><div><p>Population for guideline from https://app.magicapp.org/#/guidelines / 5691 with characteristics: COVID-19, Ventilated</p>\n</div><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: covid19</p><h3>DefinitionByTypeAndValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 404684003}\">Clinical finding (finding)</span></td><td><span title=\"Codes:{http://snomed.info/sct 840539006}\">Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder)</span></td></tr></table></blockquote><blockquote><p><b>characteristic</b></p><p><b>exclude</b>: false</p><blockquote><p><b>definitionByCombination</b></p><p><b>code</b>: Any of</p><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: oxy-administration-nasal-cannula</p><p><b>exclude</b>: false</p><h3>DefinitionByTypeAndValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 71388002}\">Procedure (procedure)</span></td><td><span title=\"Codes:{http://snomed.info/sct 371907003}\">Oxygen administration by nasal cannula (procedure)</span></td></tr></table><h3>TimeFromEvents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Event[x]</b></td><td><b>Quantity</b></td></tr><tr><td style=\"display: none\">*</td><td>covid19</td><td>0 d<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM coded = 'd')</span></td></tr></table></blockquote><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: noninvasive-ventilation</p><p><b>exclude</b>: false</p><h3>DefinitionByTypeAndValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 71388002}\">Procedure (procedure)</span></td><td><span title=\"Codes:{http://snomed.info/sct 428311008}\">Non-invasive ventilation (regime/therapy)</span></td></tr></table><h3>TimeFromEvents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Event[x]</b></td><td><b>Quantity</b></td></tr><tr><td style=\"display: none\">*</td><td>covid19</td><td>0 d<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM coded = 'd')</span></td></tr></table></blockquote><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: artificial-respiration</p><p><b>exclude</b>: false</p><h3>DefinitionByTypeAndValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 71388002}\">Procedure (procedure)</span></td><td><span title=\"Codes:{http://snomed.info/sct 40617009}\">Artificial ventilation (regime/therapy)</span></td></tr></table><h3>TimeFromEvents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Event[x]</b></td><td><b>Quantity</b></td></tr><tr><td style=\"display: none\">*</td><td>covid19</td><td>0 d<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM coded = 'd')</span></td></tr></table></blockquote></blockquote></blockquote></div>"
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"fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/outcome-mortality",
"resource" : {
"resourceType" : "Evidence",
"id" : "DexamethasoneOutcomeMortality",
"meta" : {
"profile" : [
🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/outcome-evidence-synthesis"
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Evidence_DexamethasoneOutcomeMortality\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Evidence DexamethasoneOutcomeMortality</b></p><a name=\"DexamethasoneOutcomeMortality\"> </a><a name=\"hcDexamethasoneOutcomeMortality\"> </a><a name=\"DexamethasoneOutcomeMortality-en-US\"> </a><p><b>name</b>: ExampleOutcomeEvidence</p><p><b>status</b>: Active</p><h3>RelatedArtifacts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>ResourceReference</b></td></tr><tr><td style=\"display: none\">*</td><td>Citation</td><td><a href=\"Citation-SystemicCorticosteroidsForTheTreatmentOfCOVID19.html\">Citation SystemicCorticosteroidsForTheTreatmentOfCOVID19</a></td></tr></table><blockquote><p><b>variableDefinition</b></p><p><b>variableRole</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/variable-role population}\">population</span></p><p><b>observed</b>: <a href=\"Group-StudyCohortCorticosteroidsCOVID19.html\">Group StudyCohortCriteriaSystemicCorticosteroidsCOVID19</a></p><p><b>intended</b>: <a href=\"EvidenceVariable-StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19.html\">EvidenceVariable StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19</a></p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>variableRole</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/variable-role measuredVariable}\">measured variable</span></p><p><b>observed</b>: <a href=\"EvidenceVariable-OutcomeAllCauseMortality.html\">EvidenceVariable AllCauseMortality</a></p></blockquote><p><b>synthesisType</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/synthesis-type NotApplicable}\">not applicable</span></p><blockquote><p><b>statistic</b></p><p><b>description</b>: </p><div><p>Relative effect of intervention vs. comparator</p>\n</div><p><b>statisticType</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/statistic-type C93152}\">Relative Risk</span></p><p><b>quantity</b>: 0.89</p><h3>SampleSizes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>NumberOfStudies</b></td><td><b>NumberOfParticipants</b></td></tr><tr><td style=\"display: none\">*</td><td>9</td><td>7930</td></tr></table><h3>AttributeEstimates</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Level</b></td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://terminology.hl7.org/CodeSystem/attribute-estimate-type C53324}\">Confidence interval</span></td><td>0.95</td><td>0.8-1</td></tr></table></blockquote><blockquote><p><b>statistic</b></p><p><b>description</b>: </p><div><p>Baseline risk/result in the comparison group</p>\n</div><p><b>statisticType</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/statistic-type C16726}\">Incidence</span></p><p><b>quantity</b>: 245 1/1000<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM code1/1000 = '1/1000')</span></p></blockquote></div>"
},
"name" : "ExampleOutcomeEvidence",
"status" : "active",
"relatedArtifact" : [
{
"type" : "citation",
"resourceReference" : {
🔗 "reference" : "Citation/SystemicCorticosteroidsForTheTreatmentOfCOVID19"
}
}
],
"variableDefinition" : [
{
"variableRole" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/variable-role",
"code" : "population"
}
]
},
"observed" : {
🔗 "reference" : "Group/StudyCohortCorticosteroidsCOVID19"
},
"intended" : {
🔗 "reference" : "EvidenceVariable/StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19"
}
},
{
"variableRole" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/variable-role",
"code" : "measuredVariable"
}
]
},
"observed" : {
🔗 "reference" : "EvidenceVariable/OutcomeAllCauseMortality"
}
}
],
"synthesisType" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/synthesis-type",
"code" : "NotApplicable"
}
]
},
"statistic" : [
{
"description" : "Relative effect of intervention vs. comparator",
"statisticType" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/statistic-type",
"code" : "C93152",
"display" : "Relative Risk"
}
]
},
"quantity" : {
"value" : 0.89
},
"sampleSize" : {
"numberOfStudies" : 9,
"numberOfParticipants" : 7930
},
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{
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/attribute-estimate-type",
"code" : "C53324",
"display" : "Confidence interval"
}
]
},
"level" : 0.95,
"range" : {
"low" : {
"value" : 0.8
},
"high" : {
"value" : 1
}
}
}
]
},
{
"description" : "Baseline risk/result in the comparison group",
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"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/statistic-type",
"code" : "C16726",
"display" : "Incidence"
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]
},
"quantity" : {
"value" : 245,
"system" : "http://unitsofmeasure.org",
"code" : "1/1000"
}
}
]
}
},
{
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"resource" : {
"resourceType" : "EvidenceVariable",
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🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/study-eligibility-criteria"
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"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"EvidenceVariable_StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19\"> </a><p class=\"res-header-id\"><b>Generated Narrative: EvidenceVariable StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19</b></p><a name=\"StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19\"> </a><a name=\"hcStudyEligibilityCriteriaSystemicCorticosteroidsCOVID19\"> </a><a name=\"StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19-en-US\"> </a><p><b>name</b>: StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19</p><p><b>status</b>: Active</p><blockquote><p><b>characteristic</b></p><h3>DefinitionByTypeAndValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 404684003}\">Clinical finding (finding)</span></td><td><span title=\"Codes:{http://snomed.info/sct 840539006}\">Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder)</span></td></tr></table></blockquote></div>"
},
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"characteristic" : [
{
"definitionByTypeAndValue" : {
"type" : {
"coding" : [
{
"system" : "http://snomed.info/sct",
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}
]
}
},
{
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"resource" : {
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"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"EvidenceVariable_OutcomeAllCauseMortality\"> </a><p class=\"res-header-id\"><b>Generated Narrative: EvidenceVariable OutcomeAllCauseMortality</b></p><a name=\"OutcomeAllCauseMortality\"> </a><a name=\"hcOutcomeAllCauseMortality\"> </a><a name=\"OutcomeAllCauseMortality-en-US\"> </a><p><b>name</b>: AllCauseMortality</p><p><b>status</b>: Active</p><h3>Characteristics</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Exclude</b></td><td><b>DefinitionCodeableConcept</b></td></tr><tr><td style=\"display: none\">*</td><td>false</td><td><span title=\"Codes:{http://snomed.info/sct 409651001}\">Mortality rate (observable entity)</span></td></tr></table><p><b>handling</b>: dichotomous variable</p></div>"
},
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"characteristic" : [
{
"exclude" : false,
"definitionCodeableConcept" : {
"coding" : [
{
"system" : "http://snomed.info/sct",
"code" : "409651001",
"display" : "Mortality rate (observable entity)"
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]
}
}
],
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}
},
{
"fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-justification",
"resource" : {
"resourceType" : "ArtifactAssessment",
"id" : "DexamethasoneRecommendationJustification",
"meta" : {
"profile" : [
🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-justification"
]
},
"text" : {
"status" : "extensions",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"ArtifactAssessment_DexamethasoneRecommendationJustification\"> </a><p class=\"res-header-id\"><b>Generated Narrative: ArtifactAssessment DexamethasoneRecommendationJustification</b></p><a name=\"DexamethasoneRecommendationJustification\"> </a><a name=\"hcDexamethasoneRecommendationJustification\"> </a><a name=\"DexamethasoneRecommendationJustification-en-US\"> </a><p><b>ArtifactAssessment Version</b>: v4.0</p><p><b>ArtifactAssessment Publication Status</b>: active</p><p><b>date</b>: 2020-01-03</p><p><b>artifact</b>: <a href=\"PlanDefinition-COVID19VentilatedPatientsDexamethasoneApplicationPlan.html\">PlanDefinition Dexamethasone Application in ventilated COVID-19 patients</a></p><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system strength}\">Strength of recommendation</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-cs-recommendation-strength strong-for}\">Strong for an intervention</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system consensus}\">Consensus</span></p><p><b>classifier</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/recommendation-strength strong}\">Strong</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-evidence-to-decision-certainty-type preference-and-values}\">Preference and values</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-evidence-to-decision-certainty-rating factor-not-considered}\">Factor not considered</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-evidence-to-decision-certainty-type resources}\">Resources</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-evidence-to-decision-certainty-rating no-important-issues}\">No important issues</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-evidence-to-decision-certainty-type acceptability}\">Acceptability</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-evidence-to-decision-certainty-rating factor-not-considered}\">Factor not considered</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-evidence-to-decision-certainty-type feasibility}\">Feasibility</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-evidence-to-decision-certainty-rating factor-not-considered}\">Factor not considered</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Container</p><p><b>type</b>: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system certainty-of-evidence-rating}\">Certainty of evidence rating</span></p><h3>RelatedArtifacts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td><td><b>ResourceReference</b></td></tr><tr><td style=\"display: none\">*</td><td>Justification</td><td><span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system certainty-of-evidence-rating}\">Certainty of evidence rating</span></td><td><a href=\"ArtifactAssessment-DexamethasoneRatingOutcomeMortality.html\">ArtifactAssessment: extension = v4.0,active; date = 2020-01-03; artifact[x] = ->Evidence ExampleOutcomeEvidence</a></td></tr></table></blockquote></div>"
},
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{
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"valueString" : "v4.0"
},
{
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}
],
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🔗 "reference" : "PlanDefinition/COVID19VentilatedPatientsDexamethasoneApplicationPlan"
},
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{
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{
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"code" : "strength",
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}
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{
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{
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}
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{
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{
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{
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{
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}
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}
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},
{
"informationType" : "rating",
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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🔗 "reference" : "ArtifactAssessment/DexamethasoneRatingOutcomeMortality"
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{
"fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/study-citation",
"resource" : {
"resourceType" : "Citation",
"id" : "SystemicCorticosteroidsForTheTreatmentOfCOVID19",
"meta" : {
"profile" : [
🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/study-citation"
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Citation_SystemicCorticosteroidsForTheTreatmentOfCOVID19\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Citation SystemicCorticosteroidsForTheTreatmentOfCOVID19</b></p><a name=\"SystemicCorticosteroidsForTheTreatmentOfCOVID19\"> </a><a name=\"hcSystemicCorticosteroidsForTheTreatmentOfCOVID19\"> </a><a name=\"SystemicCorticosteroidsForTheTreatmentOfCOVID19-en-US\"> </a><p><b>name</b>: SystemicCorticosteroidsForTheTreatmentOfCOVID19</p><p><b>status</b>: Active</p><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: <code>https://pubmed.ncbi.nlm.nih.gov</code>/34396514, <code>https://doi.org</code>/10.1002/14651858.CD014963, <code>https://www.ncbi.nlm.nih.gov/pmc/</code>/PMC8406706</p><h3>Titles</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td><div><p>Systemic corticosteroids for the treatment of COVID-19</p>\n</div></td></tr></table><h3>Classifications</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type publication-type}\">Publication Type</span></td><td><span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></td></tr></table></blockquote></div>"
},
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"citedArtifact" : {
"identifier" : [
{
"system" : "https://pubmed.ncbi.nlm.nih.gov",
"value" : "34396514"
},
{
"system" : "https://doi.org",
"value" : "10.1002/14651858.CD014963"
},
{
"system" : "https://www.ncbi.nlm.nih.gov/pmc/",
"value" : "PMC8406706"
}
],
"title" : [
{
"text" : "Systemic corticosteroids for the treatment of COVID-19"
}
],
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{
"type" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/cited-artifact-classification-type",
"code" : "publication-type",
"display" : "Publication Type"
}
]
},
"classifier" : [
{
"coding" : [
{
"system" : "http://hl7.org/fhir/citation-artifact-classifier",
"code" : "D016428",
"display" : "Journal Article"
}
]
}
]
}
]
}
}
}
]
}
IG © 2021+ Universitätsmedizin Greifswald. Package de.netzwerk-universitaetsmedizin.ebm-cpg#1.0.2 based on FHIR 5.0.0. Generated 2024-10-21
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