Clinical Practice Guidelines (CPG) on EBMonFHIR
1.0.2 - ci-build
Clinical Practice Guidelines (CPG) on EBMonFHIR
1.0.2 - ci-build
Clinical Practice Guidelines (CPG) on EBMonFHIR, published by Universitätsmedizin Greifswald. This guide is not an authorized publication; it is the continuous build for version 1.0.2 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/CEOsys/cpg-on-ebm-on-fhir/ and changes regularly. See the Directory of published versions
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<div xmlns="http://www.w3.org/1999/xhtml"><a name="Composition_COVID19IntensiveCareTreatmentGuideline"> </a><p class="res-header-id"><b>Generated Narrative: Composition COVID19IntensiveCareTreatmentGuideline</b></p><a name="COVID19IntensiveCareTreatmentGuideline"> </a><a name="hcCOVID19IntensiveCareTreatmentGuideline"> </a><a name="COVID19IntensiveCareTreatmentGuideline-en-US"> </a><p><b>identifier</b>: Resource identifier/113-001</p><p><b>version</b>: 7.0</p><p><b>status</b>: Final</p><p><b>type</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system clinical-practice-guideline}, {https://data.cochrane.org/concepts/ e07eN1w1Rwswg4}">Guidelines</span></p><p><b>category</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-guideline-stage-classification S3}">Evidence- and consensus-based guideline</span></p><p><b>date</b>: 2022-03-01</p><p><b>author</b>: <a href="Organization-AWMFOrganization.html">Organization Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF) e.V.</a></p><p><b>title</b>: Empfehlungen zur stationären Therapie von Patienten mit COVID-19 - Living Guideline</p><h3>RelatesTos</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>ResourceReference</b></td></tr><tr><td style="display: none">*</td><td>Citation</td><td><a href="Citation-COVID19IntensiveCareTreatmentGuidelineCitation.html">Citation COVID19_Intensive_Care_Treatment_Guideline</a></td></tr></table></div>
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<div xmlns="http://www.w3.org/1999/xhtml"><strong>Systemische Steroide:</strong> Bei Patienten mit COVID-19- und Sauerstoff-Bedarf (Niedrigfluss-Sauerstoff-Insufflation, High-Flow Nasal Cannula, Nichtinvasive Beatmung/CPAP, invasive Beatmung) soll eine Therapie mit systemischen Kortikosteroiden erfolgen. Die Therapie sollte mit 6 mg Dexamethason p.o. oder i.v. über zehn Tage erfolgen.</div>
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<div xmlns="http://www.w3.org/1999/xhtml"><strong>Systemische Steroide:</strong> Bei Patienten mit moderater Erkrankung (hospitalisiert ohne Notwendigkeit von Niedrigfluss-Sauerstoff-Insufflation) soll keine Therapie mit systemischen Kortikosteroiden erfolgen.</div>
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<div xmlns="http://www.w3.org/1999/xhtml"><a name="Citation_COVID19IntensiveCareTreatmentGuidelineCitation"> </a><p class="res-header-id"><b>Generated Narrative: Citation COVID19IntensiveCareTreatmentGuidelineCitation</b></p><a name="COVID19IntensiveCareTreatmentGuidelineCitation"> </a><a name="hcCOVID19IntensiveCareTreatmentGuidelineCitation"> </a><a name="COVID19IntensiveCareTreatmentGuidelineCitation-en-US"> </a><p><b>name</b>: COVID19_Intensive_Care_Treatment_Guideline</p><p><b>status</b>: Active</p><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: <code>https://www.awmf.org/</code>/113-001</p><h3>Versions</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Value</b></td></tr><tr><td style="display: none">*</td><td>7.0</td></tr></table><p><b>currentState</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-status-type active}">Active</span></p><h3>Titles</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Text</b></td></tr><tr><td style="display: none">*</td><td><div><p>S3-Leitlinie Stationäre Therapie von COVID-19 Patienten</p>
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<div xmlns="http://www.w3.org/1999/xhtml"><a name="PlanDefinition_COVID19DexamethasoneApplication"> </a><p class="res-header-id"><b>Generated Narrative: PlanDefinition COVID19DexamethasoneApplication</b></p><a name="COVID19DexamethasoneApplication"> </a><a name="hcCOVID19DexamethasoneApplication"> </a><a name="COVID19DexamethasoneApplication-en-US"> </a><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><blockquote><p><b>Action Combination Method</b></p><ul><li>method: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method one-or-more}">One or More</span></li></ul></blockquote><p><b>url</b>: <a href="PlanDefinition-COVID19DexamethasoneApplication.html">PlanDefinition Dexamethasone Application</a></p><p><b>version</b>: 4.0</p><p><b>name</b>: Dexamethasone_Application</p><p><b>title</b>: Dexamethasone Application</p><p><b>type</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/plan-definition-type workflow-definition}">Workflow Definition</span></p><p><b>status</b>: Active</p><p><b>experimental</b>: true</p><p><b>subject</b>: <a href="EvidenceVariable-PopulationCOVID19Ventilated.html">Population_COVID19_Ventilated</a></p><p><b>date</b>: 2021-12-12</p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: </p><div><p>Application of Dexamethasone for ventilated patients only</p>
</div><h3>RelatedArtifacts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td><td><b>ResourceReference</b></td></tr><tr><td style="display: none">*</td><td>Justification</td><td><span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system recommendation-rating}">Recommendation rating</span></td><td><a href="ArtifactAssessment-DexamethasoneRecommendationJustification.html">ArtifactAssessment: extension = v4.0,active; date = 2020-01-03; artifact[x] = ->PlanDefinition Dexamethasone Application in ventilated COVID-19 patients</a></td></tr><tr><td style="display: none">*</td><td>Citation</td><td><span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system guideline-recommendation}">Clinical practice guideline recommendation</span></td><td><a href="Citation-DexamethasoneRecommendationCitation.html">Citation DexamethasoneRecommendationCitation</a></td></tr><tr><td style="display: none">*</td><td>Citation</td><td><span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system clinical-practice-guideline}">Clinical practice guideline</span></td><td><a href="Citation-COVID19IntensiveCareTreatmentGuidelineCitation.html">Citation COVID19_Intensive_Care_Treatment_Guideline</a></td></tr></table><blockquote><p><b>action</b></p><p><b>title</b>: Dexamethasone Application</p><p><b>description</b>: </p><div><p>Application of Dexamethasone: 6 mg once per day for 10 days p.o. or i.v. for ventilated COVID-19 patients</p>
</div><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/cpg/CodeSystem/cpg-common-process guideline-based-care}">Guideline-based Care</span></p><p><b>definition</b>: <a href="PlanDefinition-COVID19VentilatedPatientsDexamethasoneApplicationPlan.html">Dexamethasone Application in ventilated COVID-19 patients</a></p></blockquote><blockquote><p><b>action</b></p><p><b>title</b>: No Dexamethasone Application</p><p><b>description</b>: </p><div><p>No Dexamethasone Application for non-ventilated COVID-19 patients</p>
</div><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/cpg/CodeSystem/cpg-common-process guideline-based-care}">Guideline-based Care</span></p><p><b>definition</b>: <a href="PlanDefinition-COVID19NonVentilatedPatientsDexamethasoneApplicationPlan.html">No Dexamethasone Application for non-ventilated COVID-19 patients</a></p></blockquote></div>
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<div xmlns="http://www.w3.org/1999/xhtml"><a name="PlanDefinition_COVID19VentilatedPatientsDexamethasoneApplicationPlan"> </a><p class="res-header-id"><b>Generated Narrative: PlanDefinition COVID19VentilatedPatientsDexamethasoneApplicationPlan</b></p><a name="COVID19VentilatedPatientsDexamethasoneApplicationPlan"> </a><a name="hcCOVID19VentilatedPatientsDexamethasoneApplicationPlan"> </a><a name="COVID19VentilatedPatientsDexamethasoneApplicationPlan-en-US"> </a><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><p><b>partOf</b>: <a href="PlanDefinition-COVID19DexamethasoneApplication.html">Dexamethasone Application</a></p><blockquote><p><b>Action Combination Method</b></p><ul><li>method: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method exactly}">Exactly</span></li><li>threshold: 1</li></ul></blockquote><p><b>url</b>: <a href="PlanDefinition-COVID19VentilatedPatientsDexamethasoneApplicationPlan.html">PlanDefinition Dexamethasone Application in ventilated COVID-19 patients</a></p><p><b>version</b>: 4.0</p><p><b>name</b>: Dexamethasone_Application</p><p><b>title</b>: Dexamethasone Application in ventilated COVID-19 patients</p><p><b>type</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/plan-definition-type eca-rule}">ECA Rule</span></p><p><b>status</b>: Active</p><p><b>experimental</b>: true</p><p><b>subject</b>: <a href="EvidenceVariable-PopulationCOVID19Ventilated.html">Population_COVID19_Ventilated</a></p><p><b>date</b>: 2021-12-12</p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: </p><div><p>Application of Dexamethasone: 6 mg once per day for 10 days p.o. or i.v. for ventilated COVID-19 patients</p>
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value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/dexamethasone-application-intravenous"/>
</action>
</PlanDefinition>
</resource>
</entry>
<entry>
<fullUrl
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-plan-non-ventilated-patients"/>
<resource>
<PlanDefinition>
<id value="COVID19NonVentilatedPatientsDexamethasoneApplicationPlan"/>
<meta>
<profile
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-plan"/>
</meta>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="PlanDefinition_COVID19NonVentilatedPatientsDexamethasoneApplicationPlan"> </a><p class="res-header-id"><b>Generated Narrative: PlanDefinition COVID19NonVentilatedPatientsDexamethasoneApplicationPlan</b></p><a name="COVID19NonVentilatedPatientsDexamethasoneApplicationPlan"> </a><a name="hcCOVID19NonVentilatedPatientsDexamethasoneApplicationPlan"> </a><a name="COVID19NonVentilatedPatientsDexamethasoneApplicationPlan-en-US"> </a><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><p><b>partOf</b>: <a href="PlanDefinition-COVID19DexamethasoneApplication.html">Dexamethasone Application</a></p><blockquote><p><b>Action Combination Method</b></p><ul><li>method: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method exactly}">Exactly</span></li><li>threshold: 1</li></ul></blockquote><p><b>url</b>: <a href="PlanDefinition-COVID19NonVentilatedPatientsDexamethasoneApplicationPlan.html">PlanDefinition No Dexamethasone Application for non-ventilated COVID-19 patients</a></p><p><b>version</b>: 4.0</p><p><b>name</b>: No_Dexamethasone_Application</p><p><b>title</b>: No Dexamethasone Application for non-ventilated COVID-19 patients</p><p><b>type</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/plan-definition-type eca-rule}">ECA Rule</span></p><p><b>status</b>: Active</p><p><b>experimental</b>: true</p><p><b>subject</b>: <a href="EvidenceVariable-PopulationCOVID19NonVentilated.html">Population_COVID19_NonVentilated</a></p><p><b>date</b>: 2021-12-12</p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: </p><div><p>No Dexamethasone Application for non-ventilated COVID19 patients</p>
</div><h3>Actions</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://snomed.info/sct 432102000}">Administration of substance (procedure)</span></td><td><a href="Bundle-COVID19IntensiveCareTreatmentGuidelineBundle.html">NoDexamethasoneApplicationActivity</a></td></tr></table></div>
</text>
<extension
url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability">
<valueCode value="computable"/>
</extension>
<extension
url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel">
<valueCode value="structured"/>
</extension>
<extension
url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-partOf">
<valueCanonical
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-dexamethasone-recommendation"/>
</extension>
<extension
url="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ext-action-combination-method">
<extension url="method">
<valueCodeableConcept>
<coding>
<system
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method"/>
<code value="exactly"/>
</coding>
</valueCodeableConcept>
</extension>
<extension url="threshold">
<valuePositiveInt value="1"/>
</extension>
</extension>
<url
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-non-ventilated-patients-no-dexamethasone-application-plan"/>
<version value="4.0"/>
<name value="No_Dexamethasone_Application"/>
<title
value="No Dexamethasone Application for non-ventilated COVID-19 patients"/>
<type>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/plan-definition-type"/>
<code value="eca-rule"/>
</coding>
</type>
<status value="active"/>
<experimental value="true"/>
<subjectCanonical
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/population/Population_COVID19_NonVentilated"/>
<date value="2021-12-12"/>
<publisher value="CPGonEBMonFHIR"/>
<description
value="No Dexamethasone Application for non-ventilated COVID19 patients"/>
<action>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="432102000"/>
<display value="Administration of substance (procedure)"/>
</coding>
</code>
<definitionCanonical
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/no-dexamethasone-application"/>
</action>
</PlanDefinition>
</resource>
</entry>
<entry>
<fullUrl
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-action-oral"/>
<resource>
<ActivityDefinition>
<id value="DexamethasoneApplicationActionOral"/>
<meta>
<profile
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/drug-administration-action"/>
</meta>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="ActivityDefinition_DexamethasoneApplicationActionOral"> </a><p class="res-header-id"><b>Generated Narrative: ActivityDefinition DexamethasoneApplicationActionOral</b></p><a name="DexamethasoneApplicationActionOral"> </a><a name="hcDexamethasoneApplicationActionOral"> </a><a name="DexamethasoneApplicationActionOral-en-US"> </a><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><p><b>url</b>: <a href="ActivityDefinition-DexamethasoneApplicationActionOral.html">ActivityDefinition DexamethasoneApplicationActionOral</a></p><p><b>version</b>: 1.0</p><p><b>name</b>: DexamethasoneApplicationActionOral</p><p><b>status</b>: Active</p><p><b>experimental</b>: true</p><p><b>subject</b>: <span title="Codes:{http://hl7.org/fhir/fhir-types Patient}">Patient</span></p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: </p><div><p>Application of Dexamethasone: 6 mg once per day for 10 days (oral route)</p>
</div><p><b>kind</b>: MedicationRequest</p><p><b>code</b>: <span title="Codes:{http://snomed.info/sct 432102000}">Administration of substance (procedure)</span></p><p><b>product</b>: <span title="Codes:{http://snomed.info/sct 372584003}, {http://fhir.de/CodeSystem/bfarm/atc C05AA09}">Dexamethasone (substance)</span></p><blockquote><p><b>dosage</b></p><p><b>timing</b>: Count 10 times, Duration 10days , Once per 1 days</p><p><b>route</b>: <span title="Codes:{http://snomed.info/sct 26643006}">Oral route</span></p><h3>DoseAndRates</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Dose[x]</b></td><td><b>Rate[x]</b></td></tr><tr><td style="display: none">*</td><td>6 mg<span style="background: LightGoldenRodYellow"> (Details: UCUM codemg = 'mg')</span></td><td>1 /d<span style="background: LightGoldenRodYellow"> (Details: UCUM code/d = '/d')</span></td></tr></table></blockquote></div>
</text>
<extension
url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability">
<valueCode value="computable"/>
</extension>
<extension
url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel">
<valueCode value="structured"/>
</extension>
<url
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/dexamethasone-application-oral"/>
<version value="1.0"/>
<name value="DexamethasoneApplicationActionOral"/>
<status value="active"/>
<experimental value="true"/>
<subjectCodeableConcept>
<coding>
<system value="http://hl7.org/fhir/fhir-types"/>
<code value="Patient"/>
</coding>
</subjectCodeableConcept>
<publisher value="CPGonEBMonFHIR"/>
<description
value="Application of Dexamethasone: 6 mg once per day for 10 days (oral route)"/>
<kind value="MedicationRequest"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="432102000"/>
<display value="Administration of substance (procedure)"/>
</coding>
</code>
<productCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="372584003"/>
<display value="Dexamethasone (substance)"/>
</coding>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<code value="C05AA09"/>
<display value="Dexamethason"/>
</coding>
</productCodeableConcept>
<dosage>
<timing>
<repeat>
<count value="10"/>
<duration value="10"/>
<durationUnit value="d"/>
<frequency value="1"/>
<period value="1"/>
<periodUnit value="d"/>
</repeat>
</timing>
<route>
<coding>
<system value="http://snomed.info/sct"/>
<code value="26643006"/>
<display value="Oral route"/>
</coding>
</route>
<doseAndRate>
<doseQuantity>
<value value="6"/>
<unit value="mg"/>
<system value="http://unitsofmeasure.org"/>
<code value="mg"/>
</doseQuantity>
<rateQuantity>
<value value="1"/>
<unit value="/d"/>
<system value="http://unitsofmeasure.org"/>
<code value="/d"/>
</rateQuantity>
</doseAndRate>
</dosage>
</ActivityDefinition>
</resource>
</entry>
<entry>
<fullUrl
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-action-intravenous"/>
<resource>
<ActivityDefinition>
<id value="DexamethasoneApplicationActionIntravenous"/>
<meta>
<profile
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/drug-administration-action"/>
</meta>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="ActivityDefinition_DexamethasoneApplicationActionIntravenous"> </a><p class="res-header-id"><b>Generated Narrative: ActivityDefinition DexamethasoneApplicationActionIntravenous</b></p><a name="DexamethasoneApplicationActionIntravenous"> </a><a name="hcDexamethasoneApplicationActionIntravenous"> </a><a name="DexamethasoneApplicationActionIntravenous-en-US"> </a><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><p><b>url</b>: <a href="ActivityDefinition-DexamethasoneApplicationActionIntravenous.html">ActivityDefinition DexamethasoneApplicationActionIntravenous</a></p><p><b>version</b>: 1.0</p><p><b>name</b>: DexamethasoneApplicationActionIntravenous</p><p><b>status</b>: Active</p><p><b>experimental</b>: true</p><p><b>subject</b>: <span title="Codes:{http://hl7.org/fhir/fhir-types Patient}">Patient</span></p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: </p><div><p>Application of Dexamethasone: 6 mg once per day for 10 days (intravenous route)</p>
</div><p><b>kind</b>: MedicationRequest</p><p><b>code</b>: <span title="Codes:{http://snomed.info/sct 432102000}">Administration of substance (procedure)</span></p><p><b>product</b>: <span title="Codes:{http://snomed.info/sct 372584003}, {http://fhir.de/CodeSystem/bfarm/atc C05AA09}">Dexamethasone (substance)</span></p><blockquote><p><b>dosage</b></p><p><b>timing</b>: Count 10 times, Duration 10days , Once per 1 days</p><p><b>route</b>: <span title="Codes:{http://snomed.info/sct 47625008}">Intravenous route</span></p><h3>DoseAndRates</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Dose[x]</b></td><td><b>Rate[x]</b></td></tr><tr><td style="display: none">*</td><td>6 mg<span style="background: LightGoldenRodYellow"> (Details: UCUM codemg = 'mg')</span></td><td>1 /d<span style="background: LightGoldenRodYellow"> (Details: UCUM code/d = '/d')</span></td></tr></table></blockquote></div>
</text>
<extension
url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability">
<valueCode value="computable"/>
</extension>
<extension
url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel">
<valueCode value="structured"/>
</extension>
<url
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/dexamethasone-application-intravenous"/>
<version value="1.0"/>
<name value="DexamethasoneApplicationActionIntravenous"/>
<status value="active"/>
<experimental value="true"/>
<subjectCodeableConcept>
<coding>
<system value="http://hl7.org/fhir/fhir-types"/>
<code value="Patient"/>
</coding>
</subjectCodeableConcept>
<publisher value="CPGonEBMonFHIR"/>
<description
value="Application of Dexamethasone: 6 mg once per day for 10 days (intravenous route)"/>
<kind value="MedicationRequest"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="432102000"/>
<display value="Administration of substance (procedure)"/>
</coding>
</code>
<productCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="372584003"/>
<display value="Dexamethasone (substance)"/>
</coding>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<code value="C05AA09"/>
<display value="Dexamethason"/>
</coding>
</productCodeableConcept>
<dosage>
<timing>
<repeat>
<count value="10"/>
<duration value="10"/>
<durationUnit value="d"/>
<frequency value="1"/>
<period value="1"/>
<periodUnit value="d"/>
</repeat>
</timing>
<route>
<coding>
<system value="http://snomed.info/sct"/>
<code value="47625008"/>
<display value="Intravenous route"/>
</coding>
</route>
<doseAndRate>
<doseQuantity>
<value value="6"/>
<unit value="mg"/>
<system value="http://unitsofmeasure.org"/>
<code value="mg"/>
</doseQuantity>
<rateQuantity>
<value value="1"/>
<unit value="/d"/>
<system value="http://unitsofmeasure.org"/>
<code value="/d"/>
</rateQuantity>
</doseAndRate>
</dosage>
</ActivityDefinition>
</resource>
</entry>
<entry>
<fullUrl
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-action-no-application"/>
<resource>
<ActivityDefinition>
<id value="NoDexamethasoneApplication"/>
<meta>
<profile
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/drug-administration-action"/>
</meta>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="ActivityDefinition_NoDexamethasoneApplication"> </a><p class="res-header-id"><b>Generated Narrative: ActivityDefinition NoDexamethasoneApplication</b></p><a name="NoDexamethasoneApplication"> </a><a name="hcNoDexamethasoneApplication"> </a><a name="NoDexamethasoneApplication-en-US"> </a><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><p><b>url</b>: <a href="ActivityDefinition-NoDexamethasoneApplication.html">ActivityDefinition NoDexamethasoneApplicationActivity</a></p><p><b>version</b>: 1.0</p><p><b>name</b>: NoDexamethasoneApplicationActivity</p><p><b>status</b>: Active</p><p><b>experimental</b>: true</p><p><b>subject</b>: <span title="Codes:{http://hl7.org/fhir/fhir-types Patient}">Patient</span></p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: </p><div><p>No Application of Dexamethasone</p>
</div><p><b>kind</b>: MedicationRequest</p><p><b>code</b>: <span title="Codes:{http://snomed.info/sct 432102000}">Administration of substance (procedure)</span></p><p><b>doNotPerform</b>: true</p><p><b>product</b>: <span title="Codes:{http://snomed.info/sct 372584003}, {http://fhir.de/CodeSystem/bfarm/atc C05AA09}">Dexamethasone (substance)</span></p></div>
</text>
<extension
url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability">
<valueCode value="computable"/>
</extension>
<extension
url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel">
<valueCode value="structured"/>
</extension>
<url
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/no-dexamethasone-application"/>
<version value="1.0"/>
<name value="NoDexamethasoneApplicationActivity"/>
<status value="active"/>
<experimental value="true"/>
<subjectCodeableConcept>
<coding>
<system value="http://hl7.org/fhir/fhir-types"/>
<code value="Patient"/>
</coding>
</subjectCodeableConcept>
<publisher value="CPGonEBMonFHIR"/>
<description value="No Application of Dexamethasone"/>
<kind value="MedicationRequest"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="432102000"/>
<display value="Administration of substance (procedure)"/>
</coding>
</code>
<doNotPerform value="true"/>
<productCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="372584003"/>
<display value="Dexamethasone (substance)"/>
</coding>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<code value="C05AA09"/>
<display value="Dexamethason"/>
</coding>
</productCodeableConcept>
</ActivityDefinition>
</resource>
</entry>
<entry>
<fullUrl
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-citation"/>
<resource>
<Citation>
<id value="DexamethasoneRecommendationCitation"/>
<meta>
<profile
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-citation"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Citation_DexamethasoneRecommendationCitation"> </a><p class="res-header-id"><b>Generated Narrative: Citation DexamethasoneRecommendationCitation</b></p><a name="DexamethasoneRecommendationCitation"> </a><a name="hcDexamethasoneRecommendationCitation"> </a><a name="DexamethasoneRecommendationCitation-en-US"> </a><p><b>name</b>: DexamethasoneRecommendationCitation</p><p><b>status</b>: Active</p><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: <code>https://api.magicapp.org/api/v1/recommendations</code>/98398</p><h3>Versions</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Value</b></td></tr><tr><td style="display: none">*</td><td>v4.0</td></tr></table><p><b>currentState</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-status-type active}">Active</span></p><h3>Titles</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Text</b></td></tr><tr><td style="display: none">*</td><td><div><p>Steroide</p>
</div></td></tr></table><h3>Classifications</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type publication-type}">Publication Type</span></td><td><span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system guideline-recommendation}">Clinical practice guideline recommendation</span></td></tr></table></blockquote></div>
</text>
<name value="DexamethasoneRecommendationCitation"/>
<status value="active"/>
<citedArtifact>
<identifier>
<system value="https://api.magicapp.org/api/v1/recommendations"/>
<value value="98398"/>
</identifier>
<version>
<value value="v4.0"/>
</version>
<currentState>
<coding>
<system value="http://hl7.org/fhir/cited-artifact-status-type"/>
<code value="active"/>
<display value="Active"/>
</coding>
</currentState>
<title>
<text value="Steroide"/>
</title>
<classification>
<type>
<coding>
<system
value="http://hl7.org/fhir/cited-artifact-classification-type"/>
<code value="publication-type"/>
<display value="Publication Type"/>
</coding>
</type>
<classifier>
<coding>
<system
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
<code value="guideline-recommendation"/>
<display value="Clinical practice guideline recommendation"/>
</coding>
</classifier>
</classification>
</citedArtifact>
</Citation>
</resource>
</entry>
<entry>
<fullUrl
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/evidence-variable-ventilated"/>
<resource>
<EvidenceVariable>
<id value="PopulationCOVID19Ventilated"/>
<meta>
<profile
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-eligibility-criteria"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="EvidenceVariable_PopulationCOVID19Ventilated"> </a><p class="res-header-id"><b>Generated Narrative: EvidenceVariable PopulationCOVID19Ventilated</b></p><a name="PopulationCOVID19Ventilated"> </a><a name="hcPopulationCOVID19Ventilated"> </a><a name="PopulationCOVID19Ventilated-en-US"> </a><p><b>url</b>: <a href="EvidenceVariable-PopulationCOVID19Ventilated.html">EvidenceVariable Population_COVID19_Ventilated</a></p><p><b>identifier</b>: <code>https://www.ceosys.de</code>/Ventilated</p><p><b>name</b>: Population_COVID19_Ventilated</p><p><b>status</b>: Active</p><p><b>description</b>: </p><div><p>Population for guideline from https://app.magicapp.org/#/guidelines / 5691 with characteristics: COVID-19, Ventilated</p>
</div><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: covid19</p><h3>DefinitionByTypeAndValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://snomed.info/sct 404684003}">Clinical finding (finding)</span></td><td><span title="Codes:{http://snomed.info/sct 840539006}">Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder)</span></td></tr></table></blockquote><blockquote><p><b>characteristic</b></p><p><b>exclude</b>: false</p><blockquote><p><b>definitionByCombination</b></p><p><b>code</b>: Any of</p><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: oxy-administration-nasal-cannula</p><p><b>exclude</b>: false</p><h3>DefinitionByTypeAndValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://snomed.info/sct 71388002}">Procedure (procedure)</span></td><td><span title="Codes:{http://snomed.info/sct 371907003}">Oxygen administration by nasal cannula (procedure)</span></td></tr></table><h3>TimeFromEvents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Event[x]</b></td><td><b>Quantity</b></td></tr><tr><td style="display: none">*</td><td>covid19</td><td>0 d<span style="background: LightGoldenRodYellow"> (Details: UCUM coded = 'd')</span></td></tr></table></blockquote><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: noninvasive-ventilation</p><p><b>exclude</b>: false</p><h3>DefinitionByTypeAndValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://snomed.info/sct 71388002}">Procedure (procedure)</span></td><td><span title="Codes:{http://snomed.info/sct 428311008}">Non-invasive ventilation (regime/therapy)</span></td></tr></table><h3>TimeFromEvents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Event[x]</b></td><td><b>Quantity</b></td></tr><tr><td style="display: none">*</td><td>covid19</td><td>0 d<span style="background: LightGoldenRodYellow"> (Details: UCUM coded = 'd')</span></td></tr></table></blockquote><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: artificial-respiration</p><p><b>exclude</b>: false</p><h3>DefinitionByTypeAndValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://snomed.info/sct 71388002}">Procedure (procedure)</span></td><td><span title="Codes:{http://snomed.info/sct 40617009}">Artificial ventilation (regime/therapy)</span></td></tr></table><h3>TimeFromEvents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Event[x]</b></td><td><b>Quantity</b></td></tr><tr><td style="display: none">*</td><td>covid19</td><td>0 d<span style="background: LightGoldenRodYellow"> (Details: UCUM coded = 'd')</span></td></tr></table></blockquote></blockquote></blockquote></div>
</text>
<url
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/population/Population_COVID19_Ventilated"/>
<identifier>
<system value="https://www.ceosys.de"/>
<value value="Ventilated"/>
</identifier>
<name value="Population_COVID19_Ventilated"/>
<status value="active"/>
<description
value="Population for guideline from https://app.magicapp.org/#/guidelines / 5691 with characteristics: COVID-19, Ventilated"/>
<characteristic>
<linkId value="covid19"/>
<definitionByTypeAndValue>
<type>
<coding>
<system value="http://snomed.info/sct"/>
<code value="404684003"/>
<display value="Clinical finding (finding)"/>
</coding>
</type>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="840539006"/>
<display
value="Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder)"/>
</coding>
</valueCodeableConcept>
</definitionByTypeAndValue>
</characteristic>
<characteristic>
<exclude value="false"/>
<definitionByCombination>
<code value="any-of"/>
<characteristic>
<linkId value="oxy-administration-nasal-cannula"/>
<exclude value="false"/>
<definitionByTypeAndValue>
<type>
<coding>
<system value="http://snomed.info/sct"/>
<code value="71388002"/>
<display value="Procedure (procedure)"/>
</coding>
</type>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="371907003"/>
<display
value="Oxygen administration by nasal cannula (procedure)"/>
</coding>
</valueCodeableConcept>
</definitionByTypeAndValue>
<timeFromEvent>
<eventId value="covid19"/>
<quantity>
<value value="0"/>
<system value="http://unitsofmeasure.org"/>
<code value="d"/>
</quantity>
</timeFromEvent>
</characteristic>
<characteristic>
<linkId value="noninvasive-ventilation"/>
<exclude value="false"/>
<definitionByTypeAndValue>
<type>
<coding>
<system value="http://snomed.info/sct"/>
<code value="71388002"/>
<display value="Procedure (procedure)"/>
</coding>
</type>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="428311008"/>
<display
value="Non-invasive ventilation (regime/therapy)"/>
</coding>
</valueCodeableConcept>
</definitionByTypeAndValue>
<timeFromEvent>
<eventId value="covid19"/>
<quantity>
<value value="0"/>
<system value="http://unitsofmeasure.org"/>
<code value="d"/>
</quantity>
</timeFromEvent>
</characteristic>
<characteristic>
<linkId value="artificial-respiration"/>
<exclude value="false"/>
<definitionByTypeAndValue>
<type>
<coding>
<system value="http://snomed.info/sct"/>
<code value="71388002"/>
<display value="Procedure (procedure)"/>
</coding>
</type>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="40617009"/>
<display value="Artificial ventilation (regime/therapy)"/>
</coding>
</valueCodeableConcept>
</definitionByTypeAndValue>
<timeFromEvent>
<eventId value="covid19"/>
<quantity>
<value value="0"/>
<system value="http://unitsofmeasure.org"/>
<code value="d"/>
</quantity>
</timeFromEvent>
</characteristic>
</definitionByCombination>
</characteristic>
</EvidenceVariable>
</resource>
</entry>
<entry>
<fullUrl
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/evidence-variable-non-ventilated"/>
<resource>
<EvidenceVariable>
<id value="PopulationCOVID19NonVentilated"/>
<meta>
<profile
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-eligibility-criteria"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="EvidenceVariable_PopulationCOVID19NonVentilated"> </a><p class="res-header-id"><b>Generated Narrative: EvidenceVariable PopulationCOVID19NonVentilated</b></p><a name="PopulationCOVID19NonVentilated"> </a><a name="hcPopulationCOVID19NonVentilated"> </a><a name="PopulationCOVID19NonVentilated-en-US"> </a><p><b>url</b>: <a href="EvidenceVariable-PopulationCOVID19NonVentilated.html">EvidenceVariable Population_COVID19_NonVentilated</a></p><p><b>identifier</b>: <code>https://www.ceosys.de</code>/NonVentilated</p><p><b>name</b>: Population_COVID19_NonVentilated</p><p><b>status</b>: Active</p><p><b>description</b>: </p><div><p>Population for guideline from https://app.magicapp.org/#/guidelines / 5691 with characteristics: COVID-19, not ventilated</p>
</div><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: covid19</p><p><b>exclude</b>: false</p><h3>DefinitionByTypeAndValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://snomed.info/sct 404684003}">Clinical finding (finding)</span></td><td><span title="Codes:{http://snomed.info/sct 840539006}">Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder)</span></td></tr></table></blockquote><blockquote><p><b>characteristic</b></p><p><b>exclude</b>: true</p><blockquote><p><b>definitionByCombination</b></p><p><b>code</b>: Any of</p><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: oxy-administration-nasal-cannula</p><p><b>exclude</b>: false</p><h3>DefinitionByTypeAndValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://snomed.info/sct 71388002}">Procedure (procedure)</span></td><td><span title="Codes:{http://snomed.info/sct 371907003}">Oxygen administration by nasal cannula (procedure)</span></td></tr></table><h3>TimeFromEvents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Event[x]</b></td><td><b>Quantity</b></td></tr><tr><td style="display: none">*</td><td>covid19</td><td>0 d<span style="background: LightGoldenRodYellow"> (Details: UCUM coded = 'd')</span></td></tr></table></blockquote><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: noninvasive-ventilation</p><p><b>exclude</b>: false</p><h3>DefinitionByTypeAndValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://snomed.info/sct 71388002}">Procedure (procedure)</span></td><td><span title="Codes:{http://snomed.info/sct 428311008}">Non-invasive ventilation (regime/therapy)</span></td></tr></table><h3>TimeFromEvents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Event[x]</b></td><td><b>Quantity</b></td></tr><tr><td style="display: none">*</td><td>covid19</td><td>0 d<span style="background: LightGoldenRodYellow"> (Details: UCUM coded = 'd')</span></td></tr></table></blockquote><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: artificial-respiration</p><p><b>exclude</b>: false</p><h3>DefinitionByTypeAndValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://snomed.info/sct 71388002}">Procedure (procedure)</span></td><td><span title="Codes:{http://snomed.info/sct 40617009}">Artificial ventilation (regime/therapy)</span></td></tr></table><h3>TimeFromEvents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Event[x]</b></td><td><b>Quantity</b></td></tr><tr><td style="display: none">*</td><td>covid19</td><td>0 d<span style="background: LightGoldenRodYellow"> (Details: UCUM coded = 'd')</span></td></tr></table></blockquote></blockquote></blockquote></div>
</text>
<url
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/population/Population_COVID19_NonVentilated"/>
<identifier>
<system value="https://www.ceosys.de"/>
<value value="NonVentilated"/>
</identifier>
<name value="Population_COVID19_NonVentilated"/>
<status value="active"/>
<description
value="Population for guideline from https://app.magicapp.org/#/guidelines / 5691 with characteristics: COVID-19, not ventilated"/>
<characteristic>
<linkId value="covid19"/>
<exclude value="false"/>
<definitionByTypeAndValue>
<type>
<coding>
<system value="http://snomed.info/sct"/>
<code value="404684003"/>
<display value="Clinical finding (finding)"/>
</coding>
</type>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="840539006"/>
<display
value="Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder)"/>
</coding>
</valueCodeableConcept>
</definitionByTypeAndValue>
</characteristic>
<characteristic>
<exclude value="true"/>
<definitionByCombination>
<code value="any-of"/>
<characteristic>
<linkId value="oxy-administration-nasal-cannula"/>
<exclude value="false"/>
<definitionByTypeAndValue>
<type>
<coding>
<system value="http://snomed.info/sct"/>
<code value="71388002"/>
<display value="Procedure (procedure)"/>
</coding>
</type>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="371907003"/>
<display
value="Oxygen administration by nasal cannula (procedure)"/>
</coding>
</valueCodeableConcept>
</definitionByTypeAndValue>
<timeFromEvent>
<eventId value="covid19"/>
<quantity>
<value value="0"/>
<system value="http://unitsofmeasure.org"/>
<code value="d"/>
</quantity>
</timeFromEvent>
</characteristic>
<characteristic>
<linkId value="noninvasive-ventilation"/>
<exclude value="false"/>
<definitionByTypeAndValue>
<type>
<coding>
<system value="http://snomed.info/sct"/>
<code value="71388002"/>
<display value="Procedure (procedure)"/>
</coding>
</type>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="428311008"/>
<display
value="Non-invasive ventilation (regime/therapy)"/>
</coding>
</valueCodeableConcept>
</definitionByTypeAndValue>
<timeFromEvent>
<eventId value="covid19"/>
<quantity>
<value value="0"/>
<system value="http://unitsofmeasure.org"/>
<code value="d"/>
</quantity>
</timeFromEvent>
</characteristic>
<characteristic>
<linkId value="artificial-respiration"/>
<exclude value="false"/>
<definitionByTypeAndValue>
<type>
<coding>
<system value="http://snomed.info/sct"/>
<code value="71388002"/>
<display value="Procedure (procedure)"/>
</coding>
</type>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="40617009"/>
<display value="Artificial ventilation (regime/therapy)"/>
</coding>
</valueCodeableConcept>
</definitionByTypeAndValue>
<timeFromEvent>
<eventId value="covid19"/>
<quantity>
<value value="0"/>
<system value="http://unitsofmeasure.org"/>
<code value="d"/>
</quantity>
</timeFromEvent>
</characteristic>
</definitionByCombination>
</characteristic>
</EvidenceVariable>
</resource>
</entry>
<entry>
<fullUrl
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/rating-outcome-mortality"/>
<resource>
<ArtifactAssessment>
<id value="DexamethasoneRatingOutcomeMortality"/>
<meta>
<profile
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/certainty-of-evidence-rating"/>
</meta>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="ArtifactAssessment_DexamethasoneRatingOutcomeMortality"> </a><p class="res-header-id"><b>Generated Narrative: ArtifactAssessment DexamethasoneRatingOutcomeMortality</b></p><a name="DexamethasoneRatingOutcomeMortality"> </a><a name="hcDexamethasoneRatingOutcomeMortality"> </a><a name="DexamethasoneRatingOutcomeMortality-en-US"> </a><p><b>ArtifactAssessment Version</b>: v4.0</p><p><b>ArtifactAssessment Publication Status</b>: active</p><p><b>date</b>: 2020-01-03</p><p><b>artifact</b>: <a href="Evidence-DexamethasoneOutcomeMortality.html">Evidence ExampleOutcomeEvidence</a></p><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/certainty-type Overall}">Overall certainty</span></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/certainty-rating moderate}">Moderate quality</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system clinical-importance}">Clinical Importance</span></p><p><b>classifier</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-clinical-importance 9}">Critical</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/certainty-type RiskOfBias}">Risk of bias</span></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/certainty-rating serious-concern}">serious concern</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/certainty-type Inconsistency}">Inconsistency</span></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/certainty-rating no-concern}">no serious concern</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/certainty-type Indirectness}">Indirectness</span></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/certainty-rating no-concern}">no serious concern</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/certainty-type Imprecision}">Imprecision</span></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/certainty-rating no-concern}">no serious concern</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/certainty-type PublicationBias}">Publication bias</span></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/certainty-rating no-concern}">no serious concern</span></p></blockquote></div>
</text>
<extension
url="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ceosys-extension-artifact-assessment-version">
<valueString value="v4.0"/>
</extension>
<extension
url="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ceosys-extension-artifact-assessment-publication-status">
<valueCode value="active"/>
</extension>
<date value="2020-01-03"/>
<artifactReference>🔗
<reference value="Evidence/DexamethasoneOutcomeMortality"/>
</artifactReference>
<content>
<informationType value="rating"/>
<type>
<coding>
<system value="http://hl7.org/fhir/certainty-type"/>
<code value="Overall"/>
<display value="Overall certainty"/>
</coding>
</type>
<classifier>
<coding>
<system value="http://hl7.org/fhir/certainty-rating"/>
<code value="moderate"/>
<display value="Moderate quality"/>
</coding>
</classifier>
</content>
<content>
<informationType value="rating"/>
<type>
<coding>
<system
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
<code value="clinical-importance"/>
<display value="Clinical Importance"/>
</coding>
</type>
<classifier>
<coding>
<system
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-clinical-importance"/>
<code value="9"/>
<display value="Critical"/>
</coding>
</classifier>
</content>
<content>
<informationType value="rating"/>
<type>
<coding>
<system value="http://hl7.org/fhir/certainty-type"/>
<code value="RiskOfBias"/>
<display value="Risk of bias"/>
</coding>
</type>
<classifier>
<coding>
<system value="http://hl7.org/fhir/certainty-rating"/>
<code value="serious-concern"/>
<display value="serious concern"/>
</coding>
</classifier>
</content>
<content>
<informationType value="rating"/>
<type>
<coding>
<system value="http://hl7.org/fhir/certainty-type"/>
<code value="Inconsistency"/>
<display value="Inconsistency"/>
</coding>
</type>
<classifier>
<coding>
<system value="http://hl7.org/fhir/certainty-rating"/>
<code value="no-concern"/>
<display value="no serious concern"/>
</coding>
</classifier>
</content>
<content>
<informationType value="rating"/>
<type>
<coding>
<system value="http://hl7.org/fhir/certainty-type"/>
<code value="Indirectness"/>
<display value="Indirectness"/>
</coding>
</type>
<classifier>
<coding>
<system value="http://hl7.org/fhir/certainty-rating"/>
<code value="no-concern"/>
<display value="no serious concern"/>
</coding>
</classifier>
</content>
<content>
<informationType value="rating"/>
<type>
<coding>
<system value="http://hl7.org/fhir/certainty-type"/>
<code value="Imprecision"/>
<display value="Imprecision"/>
</coding>
</type>
<classifier>
<coding>
<system value="http://hl7.org/fhir/certainty-rating"/>
<code value="no-concern"/>
<display value="no serious concern"/>
</coding>
</classifier>
</content>
<content>
<informationType value="rating"/>
<type>
<coding>
<system value="http://hl7.org/fhir/certainty-type"/>
<code value="PublicationBias"/>
<display value="Publication bias"/>
</coding>
</type>
<classifier>
<coding>
<system value="http://hl7.org/fhir/certainty-rating"/>
<code value="no-concern"/>
<display value="no serious concern"/>
</coding>
</classifier>
</content>
</ArtifactAssessment>
</resource>
</entry>
<entry>
<fullUrl
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/outcome-mortality"/>
<resource>
<Evidence>
<id value="DexamethasoneOutcomeMortality"/>
<meta>
<profile
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/outcome-evidence-synthesis"/>
</meta>
<text>
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<div xmlns="http://www.w3.org/1999/xhtml"><a name="Evidence_DexamethasoneOutcomeMortality"> </a><p class="res-header-id"><b>Generated Narrative: Evidence DexamethasoneOutcomeMortality</b></p><a name="DexamethasoneOutcomeMortality"> </a><a name="hcDexamethasoneOutcomeMortality"> </a><a name="DexamethasoneOutcomeMortality-en-US"> </a><p><b>name</b>: ExampleOutcomeEvidence</p><p><b>status</b>: Active</p><h3>RelatedArtifacts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>ResourceReference</b></td></tr><tr><td style="display: none">*</td><td>Citation</td><td><a href="Citation-SystemicCorticosteroidsForTheTreatmentOfCOVID19.html">Citation SystemicCorticosteroidsForTheTreatmentOfCOVID19</a></td></tr></table><blockquote><p><b>variableDefinition</b></p><p><b>variableRole</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/variable-role population}">population</span></p><p><b>observed</b>: <a href="Group-StudyCohortCorticosteroidsCOVID19.html">Group StudyCohortCriteriaSystemicCorticosteroidsCOVID19</a></p><p><b>intended</b>: <a href="EvidenceVariable-StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19.html">EvidenceVariable StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19</a></p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>variableRole</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/variable-role measuredVariable}">measured variable</span></p><p><b>observed</b>: <a href="EvidenceVariable-OutcomeAllCauseMortality.html">EvidenceVariable AllCauseMortality</a></p></blockquote><p><b>synthesisType</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/synthesis-type NotApplicable}">not applicable</span></p><blockquote><p><b>statistic</b></p><p><b>description</b>: </p><div><p>Relative effect of intervention vs. comparator</p>
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</div><p><b>statisticType</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/statistic-type C16726}">Incidence</span></p><p><b>quantity</b>: 245 1/1000<span style="background: LightGoldenRodYellow"> (Details: UCUM code1/1000 = '1/1000')</span></p></blockquote></div>
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<div xmlns="http://www.w3.org/1999/xhtml"><a name="EvidenceVariable_StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19"> </a><p class="res-header-id"><b>Generated Narrative: EvidenceVariable StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19</b></p><a name="StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19"> </a><a name="hcStudyEligibilityCriteriaSystemicCorticosteroidsCOVID19"> </a><a name="StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19-en-US"> </a><p><b>name</b>: StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19</p><p><b>status</b>: Active</p><blockquote><p><b>characteristic</b></p><h3>DefinitionByTypeAndValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://snomed.info/sct 404684003}">Clinical finding (finding)</span></td><td><span title="Codes:{http://snomed.info/sct 840539006}">Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder)</span></td></tr></table></blockquote></div>
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<div xmlns="http://www.w3.org/1999/xhtml"><a name="EvidenceVariable_OutcomeAllCauseMortality"> </a><p class="res-header-id"><b>Generated Narrative: EvidenceVariable OutcomeAllCauseMortality</b></p><a name="OutcomeAllCauseMortality"> </a><a name="hcOutcomeAllCauseMortality"> </a><a name="OutcomeAllCauseMortality-en-US"> </a><p><b>name</b>: AllCauseMortality</p><p><b>status</b>: Active</p><h3>Characteristics</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Exclude</b></td><td><b>DefinitionCodeableConcept</b></td></tr><tr><td style="display: none">*</td><td>false</td><td><span title="Codes:{http://snomed.info/sct 409651001}">Mortality rate (observable entity)</span></td></tr></table><p><b>handling</b>: dichotomous variable</p></div>
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<div xmlns="http://www.w3.org/1999/xhtml"><a name="ArtifactAssessment_DexamethasoneRecommendationJustification"> </a><p class="res-header-id"><b>Generated Narrative: ArtifactAssessment DexamethasoneRecommendationJustification</b></p><a name="DexamethasoneRecommendationJustification"> </a><a name="hcDexamethasoneRecommendationJustification"> </a><a name="DexamethasoneRecommendationJustification-en-US"> </a><p><b>ArtifactAssessment Version</b>: v4.0</p><p><b>ArtifactAssessment Publication Status</b>: active</p><p><b>date</b>: 2020-01-03</p><p><b>artifact</b>: <a href="PlanDefinition-COVID19VentilatedPatientsDexamethasoneApplicationPlan.html">PlanDefinition Dexamethasone Application in ventilated COVID-19 patients</a></p><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system strength}">Strength of recommendation</span></p><p><b>classifier</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-cs-recommendation-strength strong-for}">Strong for an intervention</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system consensus}">Consensus</span></p><p><b>classifier</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/recommendation-strength strong}">Strong</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-evidence-to-decision-certainty-type preference-and-values}">Preference and values</span></p><p><b>classifier</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-evidence-to-decision-certainty-rating factor-not-considered}">Factor not considered</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-evidence-to-decision-certainty-type resources}">Resources</span></p><p><b>classifier</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-evidence-to-decision-certainty-rating no-important-issues}">No important issues</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-evidence-to-decision-certainty-type acceptability}">Acceptability</span></p><p><b>classifier</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-evidence-to-decision-certainty-rating factor-not-considered}">Factor not considered</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-evidence-to-decision-certainty-type feasibility}">Feasibility</span></p><p><b>classifier</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-evidence-to-decision-certainty-rating factor-not-considered}">Factor not considered</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Container</p><p><b>type</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system certainty-of-evidence-rating}">Certainty of evidence rating</span></p><h3>RelatedArtifacts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td><td><b>ResourceReference</b></td></tr><tr><td style="display: none">*</td><td>Justification</td><td><span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system certainty-of-evidence-rating}">Certainty of evidence rating</span></td><td><a href="ArtifactAssessment-DexamethasoneRatingOutcomeMortality.html">ArtifactAssessment: extension = v4.0,active; date = 2020-01-03; artifact[x] = ->Evidence ExampleOutcomeEvidence</a></td></tr></table></blockquote></div>
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<div xmlns="http://www.w3.org/1999/xhtml"><a name="Citation_SystemicCorticosteroidsForTheTreatmentOfCOVID19"> </a><p class="res-header-id"><b>Generated Narrative: Citation SystemicCorticosteroidsForTheTreatmentOfCOVID19</b></p><a name="SystemicCorticosteroidsForTheTreatmentOfCOVID19"> </a><a name="hcSystemicCorticosteroidsForTheTreatmentOfCOVID19"> </a><a name="SystemicCorticosteroidsForTheTreatmentOfCOVID19-en-US"> </a><p><b>name</b>: SystemicCorticosteroidsForTheTreatmentOfCOVID19</p><p><b>status</b>: Active</p><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: <code>https://pubmed.ncbi.nlm.nih.gov</code>/34396514, <code>https://doi.org</code>/10.1002/14651858.CD014963, <code>https://www.ncbi.nlm.nih.gov/pmc/</code>/PMC8406706</p><h3>Titles</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Text</b></td></tr><tr><td style="display: none">*</td><td><div><p>Systemic corticosteroids for the treatment of COVID-19</p>
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IG © 2021+ Universitätsmedizin Greifswald. Package de.netzwerk-universitaetsmedizin.ebm-cpg#1.0.2 based on FHIR 5.0.0. Generated 2024-10-21
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