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4.3.2.372 CodeSystem http://hl7.org/fhir/substance-glycosylation-type

Responsible Owner: Biomedical Research and Regulation icon Work Group Informative Use Context: Country: World, Not Intended for Production use
Official URL: http://hl7.org/fhir/substance-glycosylation-type Version: 6.0.0-ballot4
active as of 2026-06-30 Computable Name: SubstanceGlycosylationTypeExample
Flags: Experimental, CaseSensitive, Complete. All codes ValueSet: Substance Glycosylation Type OID: TBD

This Code system is used in the following FHIR core-defined or referenced value sets:

  • ValueSet: Substance Glycosylation Type (A categorical pattern of glycosylation for a substance, typically derived from the production cell line or source organism.)
  • ValueSet: Substance Glycosylation Type (A categorical pattern of glycosylation for a substance, typically derived from the production cell line or source organism.)

4.3.2.372.1 Definition

A categorical pattern of glycosylation for a substance, typically derived from the production cell line or source organism. Applicable to proteins and structurally diverse substances (notably vaccines) per ISO 11238.

4.3.2.372.2 Content

Generated Narrative: CodeSystem substance-glycosylation-type

Last updated: 2026-07-04T18:53:58.933Z

This case-sensitive code system http://hl7.org/fhir/substance-glycosylation-type defines the following codes:

CodeDisplayDefinitionCopy
human Human Glycosylation pattern from human cell lines (e.g. HEK293, PER.C6). No non-human glycan epitopes. btn btn
mammalian Mammalian (non-human) Glycosylation pattern from non-human mammalian cell lines such as CHO, BHK or NS0. The most common pattern for therapeutic monoclonal antibodies. btn btn
old-world-monkey Old World Monkey Glycosylation pattern from old world monkey cell lines such as Vero or COS. Often used for vaccine production. btn btn
mouse Murine Glycosylation pattern from murine cell lines such as NS0 or SP2/0 hybridoma. Carries the alpha-1,3-galactose epitope which can be immunogenic in humans. btn btn
mammalian-afucosylated Mammalian, afucosylated Glycosylation pattern from engineered mammalian cell lines lacking fucosyltransferase (e.g. Potelligent), producing antibodies with enhanced ADCC activity. btn btn
avian Avian Glycosylation pattern from egg-derived or avian cell line production. Common for influenza vaccines. btn btn
insect Insect cell Glycosylation pattern from insect cell expression systems such as baculovirus/Sf9. Used for some recombinant proteins and vaccines. btn btn
yeast Yeast Native yeast glycosylation pattern (e.g. Saccharomyces cerevisiae). Examples include insulin and hepatitis B surface antigen. btn btn
yeast-humanised Yeast, humanised Glycosylation pattern from glyco-engineered yeast (e.g. Pichia pastoris GlycoFi systems) that produces human-like glycan structures. btn btn
plant Plant Glycosylation pattern from plant or plant cell culture production (e.g. taliglucerase alfa from carrot cells). btn btn
bacterial Bacterial Bacterial expression (typically E. coli). Generally unglycosylated; included for completeness when the substance has been characterised as such. btn btn

 

See the full registry of code systems defined as part of FHIR.

Explanation of the columns that may appear on this page:

Level A few code lists that FHIR defines are hierarchical - each code is assigned a level. See Code System for further information.
Source The source of the definition of the code (when the value set draws in codes defined elsewhere)
Code The code (used as the code in the resource instance). If the code is in italics, this indicates that the code is not selectable ('Abstract')
Display The display (used in the display element of a Coding). If there is no display, implementers should not simply display the code, but map the concept into their application
Definition An explanation of the meaning of the concept
Comments Additional notes about how to use the code