Definition for Code SystemSubstanceGlycosylationTypeExample

{
  "resourceType" : "CodeSystem",
  "id" : "substance-glycosylation-type",
  "meta" : {
    "lastUpdated" : "2026-07-04T18:53:58.933+00:00"
  },
  "text" : {
    "status" : "generated",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: CodeSystem substance-glycosylation-type</b></p><a name=\"substance-glycosylation-type\"> </a><a name=\"hcsubstance-glycosylation-type\"> </a><p>This case-sensitive code system <code>http://hl7.org/fhir/substance-glycosylation-type</code> defines the following codes:</p><table class=\"codes\"><tr><td style=\"white-space:nowrap\"><b>Code</b></td><td><b>Display</b></td><td><b>Definition</b></td></tr><tr><td style=\"white-space:nowrap\">human<a name=\"substance-glycosylation-type-human\"> </a></td><td>Human</td><td>Glycosylation pattern from human cell lines (e.g. HEK293, PER.C6). No non-human glycan epitopes.</td></tr><tr><td style=\"white-space:nowrap\">mammalian<a name=\"substance-glycosylation-type-mammalian\"> </a></td><td>Mammalian (non-human)</td><td>Glycosylation pattern from non-human mammalian cell lines such as CHO, BHK or NS0. The most common pattern for therapeutic monoclonal antibodies.</td></tr><tr><td style=\"white-space:nowrap\">old-world-monkey<a name=\"substance-glycosylation-type-old-world-monkey\"> </a></td><td>Old World Monkey</td><td>Glycosylation pattern from old world monkey cell lines such as Vero or COS. Often used for vaccine production.</td></tr><tr><td style=\"white-space:nowrap\">mouse<a name=\"substance-glycosylation-type-mouse\"> </a></td><td>Murine</td><td>Glycosylation pattern from murine cell lines such as NS0 or SP2/0 hybridoma. Carries the alpha-1,3-galactose epitope which can be immunogenic in humans.</td></tr><tr><td style=\"white-space:nowrap\">mammalian-afucosylated<a name=\"substance-glycosylation-type-mammalian-afucosylated\"> </a></td><td>Mammalian, afucosylated</td><td>Glycosylation pattern from engineered mammalian cell lines lacking fucosyltransferase (e.g. Potelligent), producing antibodies with enhanced ADCC activity.</td></tr><tr><td style=\"white-space:nowrap\">avian<a name=\"substance-glycosylation-type-avian\"> </a></td><td>Avian</td><td>Glycosylation pattern from egg-derived or avian cell line production. Common for influenza vaccines.</td></tr><tr><td style=\"white-space:nowrap\">insect<a name=\"substance-glycosylation-type-insect\"> </a></td><td>Insect cell</td><td>Glycosylation pattern from insect cell expression systems such as baculovirus/Sf9. Used for some recombinant proteins and vaccines.</td></tr><tr><td style=\"white-space:nowrap\">yeast<a name=\"substance-glycosylation-type-yeast\"> </a></td><td>Yeast</td><td>Native yeast glycosylation pattern (e.g. Saccharomyces cerevisiae). Examples include insulin and hepatitis B surface antigen.</td></tr><tr><td style=\"white-space:nowrap\">yeast-humanised<a name=\"substance-glycosylation-type-yeast-humanised\"> </a></td><td>Yeast, humanised</td><td>Glycosylation pattern from glyco-engineered yeast (e.g. Pichia pastoris GlycoFi systems) that produces human-like glycan structures.</td></tr><tr><td style=\"white-space:nowrap\">plant<a name=\"substance-glycosylation-type-plant\"> </a></td><td>Plant</td><td>Glycosylation pattern from plant or plant cell culture production (e.g. taliglucerase alfa from carrot cells).</td></tr><tr><td style=\"white-space:nowrap\">bacterial<a name=\"substance-glycosylation-type-bacterial\"> </a></td><td>Bacterial</td><td>Bacterial expression (typically E. coli). Generally unglycosylated; included for completeness when the substance has been characterised as such.</td></tr></table></div>"
  },
  "extension" : [{
    "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-wg",
    "valueCode" : "brr"
  },
  {
    "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-standards-status",
    "valueCode" : "informative"
  },
  {
    "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-fmm",
    "valueInteger" : 1
  }],
  "url" : "http://hl7.org/fhir/substance-glycosylation-type",
  "version" : "6.0.0-ballot4",
  "name" : "SubstanceGlycosylationTypeExample",
  "title" : "Substance Glycosylation Type",
  "status" : "active",
  "experimental" : true,
  "date" : "2026-06-30",
  "publisher" : "HL7 (FHIR Project)",
  "contact" : [{
    "telecom" : [{
      "system" : "url",
      "value" : "http://hl7.org/fhir"
    },
    {
      "system" : "email",
      "value" : "fhir@lists.hl7.org"
    }]
  }],
  "description" : "A categorical pattern of glycosylation for a substance, typically derived from the production cell line or source organism. Applicable to proteins and structurally diverse substances (notably vaccines) per ISO 11238.",
  "jurisdiction" : [{
    "coding" : [{
      "system" : "http://unstats.un.org/unsd/methods/m49/m49.htm",
      "code" : "001",
      "display" : "World"
    }]
  }],
  "caseSensitive" : true,
  "valueSet" : "http://hl7.org/fhir/ValueSet/substance-glycosylation-type",
  "content" : "complete",
  "concept" : [{
    "code" : "human",
    "display" : "Human",
    "definition" : "Glycosylation pattern from human cell lines (e.g. HEK293, PER.C6). No non-human glycan epitopes."
  },
  {
    "code" : "mammalian",
    "display" : "Mammalian (non-human)",
    "definition" : "Glycosylation pattern from non-human mammalian cell lines such as CHO, BHK or NS0. The most common pattern for therapeutic monoclonal antibodies."
  },
  {
    "code" : "old-world-monkey",
    "display" : "Old World Monkey",
    "definition" : "Glycosylation pattern from old world monkey cell lines such as Vero or COS. Often used for vaccine production."
  },
  {
    "code" : "mouse",
    "display" : "Murine",
    "definition" : "Glycosylation pattern from murine cell lines such as NS0 or SP2/0 hybridoma. Carries the alpha-1,3-galactose epitope which can be immunogenic in humans."
  },
  {
    "code" : "mammalian-afucosylated",
    "display" : "Mammalian, afucosylated",
    "definition" : "Glycosylation pattern from engineered mammalian cell lines lacking fucosyltransferase (e.g. Potelligent), producing antibodies with enhanced ADCC activity."
  },
  {
    "code" : "avian",
    "display" : "Avian",
    "definition" : "Glycosylation pattern from egg-derived or avian cell line production. Common for influenza vaccines."
  },
  {
    "code" : "insect",
    "display" : "Insect cell",
    "definition" : "Glycosylation pattern from insect cell expression systems such as baculovirus/Sf9. Used for some recombinant proteins and vaccines."
  },
  {
    "code" : "yeast",
    "display" : "Yeast",
    "definition" : "Native yeast glycosylation pattern (e.g. Saccharomyces cerevisiae). Examples include insulin and hepatitis B surface antigen."
  },
  {
    "code" : "yeast-humanised",
    "display" : "Yeast, humanised",
    "definition" : "Glycosylation pattern from glyco-engineered yeast (e.g. Pichia pastoris GlycoFi systems) that produces human-like glycan structures."
  },
  {
    "code" : "plant",
    "display" : "Plant",
    "definition" : "Glycosylation pattern from plant or plant cell culture production (e.g. taliglucerase alfa from carrot cells)."
  },
  {
    "code" : "bacterial",
    "display" : "Bacterial",
    "definition" : "Bacterial expression (typically E. coli). Generally unglycosylated; included for completeness when the substance has been characterised as such."
  }]
}