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4.4.1.268 ValueSet http://hl7.org/fhir/ValueSet/substance-glycosylation-type

Responsible Owner: Biomedical Research and Regulation icon Work Group Informative Use Context: Country: World
Official URL: http://hl7.org/fhir/ValueSet/substance-glycosylation-type Version: 6.0.0-ballot4
active as of 2026-06-30 Computable Name: SubstanceGlycosylationType
Flags: Immutable OID:

This value set is used in the following places:

4.4.1.268.1 Definition

A categorical pattern of glycosylation for a substance, typically derived from the production cell line or source organism.

4.4.1.268.2 Content Logical Definition

Generated Narrative: ValueSet substance-glycosylation-type

Last updated: 2026-07-04T18:53:58.933Z

 

4.4.1.268.3 Expansion

This expansion generated 04 Jul 2026

ValueSet

Expansion performed internally based on codesystem Substance Glycosylation Type v6.0.0-ballot4 (CodeSystem)

This value set contains 11 concepts

SystemCodeDisplayDefinition
http://hl7.org/fhir/substance-glycosylation-type   human Human Glycosylation pattern from human cell lines (e.g. HEK293, PER.C6). No non-human glycan epitopes.
http://hl7.org/fhir/substance-glycosylation-type   mammalian Mammalian (non-human) Glycosylation pattern from non-human mammalian cell lines such as CHO, BHK or NS0. The most common pattern for therapeutic monoclonal antibodies.
http://hl7.org/fhir/substance-glycosylation-type   old-world-monkey Old World Monkey Glycosylation pattern from old world monkey cell lines such as Vero or COS. Often used for vaccine production.
http://hl7.org/fhir/substance-glycosylation-type   mouse Murine Glycosylation pattern from murine cell lines such as NS0 or SP2/0 hybridoma. Carries the alpha-1,3-galactose epitope which can be immunogenic in humans.
http://hl7.org/fhir/substance-glycosylation-type   mammalian-afucosylated Mammalian, afucosylated Glycosylation pattern from engineered mammalian cell lines lacking fucosyltransferase (e.g. Potelligent), producing antibodies with enhanced ADCC activity.
http://hl7.org/fhir/substance-glycosylation-type   avian Avian Glycosylation pattern from egg-derived or avian cell line production. Common for influenza vaccines.
http://hl7.org/fhir/substance-glycosylation-type   insect Insect cell Glycosylation pattern from insect cell expression systems such as baculovirus/Sf9. Used for some recombinant proteins and vaccines.
http://hl7.org/fhir/substance-glycosylation-type   yeast Yeast Native yeast glycosylation pattern (e.g. Saccharomyces cerevisiae). Examples include insulin and hepatitis B surface antigen.
http://hl7.org/fhir/substance-glycosylation-type   yeast-humanised Yeast, humanised Glycosylation pattern from glyco-engineered yeast (e.g. Pichia pastoris GlycoFi systems) that produces human-like glycan structures.
http://hl7.org/fhir/substance-glycosylation-type   plant Plant Glycosylation pattern from plant or plant cell culture production (e.g. taliglucerase alfa from carrot cells).
http://hl7.org/fhir/substance-glycosylation-type   bacterial Bacterial Bacterial expression (typically E. coli). Generally unglycosylated; included for completeness when the substance has been characterised as such.

 

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