minimal Common Oncology Data Elements (mCODE) Implementation Guide
4.0.0-ballot - STU4 Ballot United States of America flag

minimal Common Oncology Data Elements (mCODE) Implementation Guide, published by HL7 International / Clinical Interoperability Council. This guide is not an authorized publication; it is the continuous build for version 4.0.0-ballot built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/fhir-mCODE-ig/ and changes regularly. See the Directory of published versions

Resource Profile: Genomic Region Studied Profile

Official URL: http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-region-studied Version: 4.0.0-ballot
Active as of 2024-04-09 Maturity Level: 1 Computable Name: GenomicRegionStudied
Other Identifiers: OID:2.16.840.1.113883.4.642.40.15.42.18

A subset of genes or genomic regions of interest in a targeted resequencing study.

Usage

This profile identifies a specific region analyzed for gene mutations or variants in a given genomic test. For example, exome sequencing tests could analyze multiple non-contiguous regions. Each region is designated by a range of start and end location and referencing a coordinate system which is 0-based or 1-based.

RegionStudied is noted at the GenomicsReport level and not directly tied to a given GenomicVariant.

Conformance

Observation resources associated with an in-scope patient with DiagnosticReport.code LOINC 53041-0 SHALL conform to this profile. Beyond this requirement, a producer of resources SHOULD ensure that any resource instance associated with an in-scope patient that would reasonably be expected to conform to this profile SHOULD be published in this form.

Usage:

Changes since version true:

  • No changes
  • Formal Views of Profile Content

    Description of Profiles, Differentials, Snapshots and how the different presentations work.

    This structure is derived from RegionStudied

    NameFlagsCard.TypeDescription & Constraintsdoco
    .. Observation 0..* RegionStudied Region Studied
    ... status S 1..1 code registered | preliminary | final | amended +
    ... category S 1..* CodeableConcept Classification of type of observation
    ... category:labCategory 1..1 CodeableConcept Classification of type of observation
    Required Pattern: At least the following
    .... coding 1..* Coding Code defined by a terminology system
    Fixed Value: (complex)
    ..... system 1..1 uri Identity of the terminology system
    Fixed Value: http://terminology.hl7.org/CodeSystem/observation-category
    ..... code 1..1 code Symbol in syntax defined by the system
    Fixed Value: laboratory
    .... coding 1..1 Coding Code defined by a terminology system
    ... subject S 1..1 Reference(Cancer Patient Profile) Who and/or what the observation is about
    ... Slices for effective[x] S 0..1 dateTime, Period, Timing, instant Clinically relevant time/time-period for observation
    Slice: Unordered, Open by type:$this
    .... effective[x]:effectiveDateTime S 0..1 dateTime Clinically relevant time/time-period for observation
    ... value[x] 0..0 Quantity, CodeableConcept, string, boolean, integer, Range, Ratio, SampledData, time, dateTime, Period
    ... dataAbsentReason S 0..1 CodeableConcept Why the result is missing
    ... component S 0..* BackboneElement Component results
    ... component:gene-studied S 0..1 BackboneElement Gene Studied
    .... code S 1..1 CodeableConcept 48018-6
    .... value[x] S 1..1 CodeableConcept The HGNC gene symbol is to be used as display text and the HGNC gene ID used as the code. If no HGNC code issued for this gene yet, NCBI gene IDs SHALL be used.
    ... component:gene-mutations S 0..1 BackboneElement Gene Mutations ID
    .... code S 1..1 CodeableConcept 36908-2
    .... value[x] S 1..1 CodeableConcept Actual component result
    ... component:region-description S 0..1 BackboneElement Region Description
    .... code S 1..1 CodeableConcept 81293-3
    .... value[x] S 0..1 string Actual component result
    ... component:ranges-examined S 0..* BackboneElement Range(s) of DNA sequence examined
    .... code S 1..1 CodeableConcept 51959-5
    .... value[x] S 0..1 Range Actual component result
    ... component:coordinate-system S 0..1 BackboneElement Coordinate System
    .... code S 1..1 CodeableConcept 92822-6
    .... value[x] S 1..1 CodeableConcept 0-based interval counting | 0-based character counting | 1-based character counting
    ... component:genomic-ref-seq S 0..1 BackboneElement Genomic Reference Sequence
    .... code S 1..1 CodeableConcept 48013-7
    .... value[x] S 1..1 CodeableConcept Versioned genomic reference sequence identifier.

    doco Documentation for this format
    NameFlagsCard.TypeDescription & Constraintsdoco
    .. Observation C 0..* RegionStudied Region Studied
    obs-6: dataAbsentReason SHALL only be present if Observation.value[x] is not present
    obs-7: If Observation.code is the same as an Observation.component.code then the value element associated with the code SHALL NOT be present
    ... implicitRules ?!Σ 0..1 uri A set of rules under which this content was created
    ... secondary-finding 0..1 CodeableConcept Secondary findings are genetic test results that provide information about variants in a gene unrelated to the primary purpose for the testing, most often discovered when [Whole Exome Sequencing (WES)](https://en.wikipedia.org/wiki/Exome_sequencing) or [Whole Genome Sequencing (WGS)](https://en.wikipedia.org/wiki/Whole_genome_sequencing) is performed. This extension should be used to denote when a genetic finding is being shared as a secondary finding, and ideally refer to a corresponding guideline or policy statement. For more detail, please see: https://ghr.nlm.nih.gov/primer/testing/secondaryfindings
    URL: http://hl7.org/fhir/StructureDefinition/observation-secondaryFinding
    Binding: GeneticObservationSecondaryFindings (extensible): Codes to denote a guideline or policy statement when a genetic test result is being shared as a secondary finding.


    ... body-structure 0..1 Reference(BodyStructure) Target anatomic location or structure
    URL: http://hl7.org/fhir/StructureDefinition/bodySite
    ... status ?!SΣ 1..1 code registered | preliminary | final | amended +
    Binding: ObservationStatus (required): Codes providing the status of an observation.

    ... Slices for category S 1..* CodeableConcept Classification of type of observation
    Slice: Unordered, Open by value:coding
    Binding: ObservationCategoryCodes (preferred): Codes for high level observation categories.


    .... category:labCategory 1..1 CodeableConcept Classification of type of observation
    Binding: ObservationCategoryCodes (preferred): Codes for high level observation categories.



    Required Pattern: At least the following
    ..... coding 1..* Coding Code defined by a terminology system
    Fixed Value: (complex)
    ...... system 1..1 uri Identity of the terminology system
    Fixed Value: http://terminology.hl7.org/CodeSystem/observation-category
    ...... code 1..1 code Symbol in syntax defined by the system
    Fixed Value: laboratory
    ..... coding Σ 1..1 Coding Code defined by a terminology system

    Required Pattern: At least the following
    ...... system 1..1 uri Identity of the terminology system
    Fixed Value: http://terminology.hl7.org/CodeSystem/observation-category
    ...... code 1..1 code Symbol in syntax defined by the system
    Fixed Value: laboratory
    ... code SΣ 1..1 CodeableConcept 53041-0
    Binding: LOINCCodes (example): Codes identifying names of simple observations.


    Required Pattern: At least the following
    .... coding 1..* Coding Code defined by a terminology system
    Fixed Value: (complex)
    ..... system 1..1 uri Identity of the terminology system
    Fixed Value: http://loinc.org
    ..... code 1..1 code Symbol in syntax defined by the system
    Fixed Value: 53041-0
    ... subject SΣ 1..1 Reference(Cancer Patient Profile) Who and/or what the observation is about
    ... Slices for effective[x] SΣ 0..1 Clinically relevant time/time-period for observation
    Slice: Unordered, Open by type:$this
    .... effectiveDateTime dateTime
    .... effectivePeriod Period
    .... effectiveTiming Timing
    .... effectiveInstant instant
    .... effective[x]:effectiveDateTime SΣ 0..1 dateTime Clinically relevant time/time-period for observation
    ... dataAbsentReason SC 0..1 CodeableConcept Why the result is missing
    Binding: DataAbsentReason (extensible): Codes specifying why the result (Observation.value[x]) is missing.

    ... Slices for component SΣ 0..* BackboneElement Component results
    Slice: Unordered, Open by pattern:code
    .... component:All Slices Content/Rules for all slices
    ..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
    ..... code Σ 1..1 CodeableConcept Type of component observation (code / type)
    Binding: LOINCCodes (example): Codes identifying names of simple observations.

    .... component:conclusion-string Σ 0..1 BackboneElement Clinical Conclusion
    ..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
    ..... code Σ 1..1 CodeableConcept conclusion-string
    Binding: LOINCCodes (example): Codes identifying names of simple observations.


    Required Pattern: At least the following
    ...... coding 1..* Coding Code defined by a terminology system
    Fixed Value: (complex)
    ....... system 1..1 uri Identity of the terminology system
    Fixed Value: http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs
    ....... code 1..1 code Symbol in syntax defined by the system
    Fixed Value: conclusion-string
    .... component:gene-studied SΣ 0..1 BackboneElement Gene Studied
    ..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
    ..... code SΣ 1..1 CodeableConcept 48018-6
    Binding: LOINCCodes (example): Codes identifying names of simple observations.


    Required Pattern: At least the following
    ...... coding 1..* Coding Code defined by a terminology system
    Fixed Value: (complex)
    ....... system 1..1 uri Identity of the terminology system
    Fixed Value: http://loinc.org
    ....... code 1..1 code Symbol in syntax defined by the system
    Fixed Value: 48018-6
    ..... value[x] SΣ 1..1 CodeableConcept The HGNC gene symbol is to be used as display text and the HGNC gene ID used as the code. If no HGNC code issued for this gene yet, NCBI gene IDs SHALL be used.
    Binding: HUGO Gene Nomenclature Committee Gene Names (HGNC) (extensible)
    .... component:gene-mutations SΣ 0..1 BackboneElement Gene Mutations ID
    ..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
    ..... code SΣ 1..1 CodeableConcept 36908-2
    Binding: LOINCCodes (example): Codes identifying names of simple observations.


    Required Pattern: At least the following
    ...... coding 1..* Coding Code defined by a terminology system
    Fixed Value: (complex)
    ....... system 1..1 uri Identity of the terminology system
    Fixed Value: http://loinc.org
    ....... code 1..1 code Symbol in syntax defined by the system
    Fixed Value: 36908-2
    ..... value[x] SΣ 1..1 CodeableConcept Actual component result
    Binding: Human Genome Variation Society (HGVS) Nomenclature (required)
    .... component:region-description SΣ 0..1 BackboneElement Region Description
    ..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
    ..... code SΣ 1..1 CodeableConcept 81293-3
    Binding: LOINCCodes (example): Codes identifying names of simple observations.


    Required Pattern: At least the following
    ...... coding 1..* Coding Code defined by a terminology system
    Fixed Value: (complex)
    ....... system 1..1 uri Identity of the terminology system
    Fixed Value: http://loinc.org
    ....... code 1..1 code Symbol in syntax defined by the system
    Fixed Value: 81293-3
    ..... value[x] SΣ 0..1 string Actual component result
    .... component:region-coverage Σ 0..1 BackboneElement Region Coverage
    ..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
    ..... code Σ 1..1 CodeableConcept region-coverage
    Binding: LOINCCodes (example): Codes identifying names of simple observations.


    Required Pattern: At least the following
    ...... coding 1..* Coding Code defined by a terminology system
    Fixed Value: (complex)
    ....... system 1..1 uri Identity of the terminology system
    Fixed Value: http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs
    ....... code 1..1 code Symbol in syntax defined by the system
    Fixed Value: region-coverage
    .... component:ranges-examined SΣ 0..* BackboneElement Range(s) of DNA sequence examined
    ..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
    ..... code SΣ 1..1 CodeableConcept 51959-5
    Binding: LOINCCodes (example): Codes identifying names of simple observations.


    Required Pattern: At least the following
    ...... coding 1..* Coding Code defined by a terminology system
    Fixed Value: (complex)
    ....... system 1..1 uri Identity of the terminology system
    Fixed Value: http://loinc.org
    ....... code 1..1 code Symbol in syntax defined by the system
    Fixed Value: 51959-5
    ..... value[x] SΣ 0..1 Range Actual component result
    .... component:coordinate-system SΣ 0..1 BackboneElement Coordinate System
    ..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
    ..... code SΣ 1..1 CodeableConcept 92822-6
    Binding: LOINCCodes (example): Codes identifying names of simple observations.


    Required Pattern: At least the following
    ...... coding 1..* Coding Code defined by a terminology system
    Fixed Value: (complex)
    ....... system 1..1 uri Identity of the terminology system
    Fixed Value: http://loinc.org
    ....... code 1..1 code Symbol in syntax defined by the system
    Fixed Value: 92822-6
    ..... value[x] SΣ 1..1 CodeableConcept 0-based interval counting | 0-based character counting | 1-based character counting
    Binding: LOINC Answer List LL5323-2 (extensible)
    .... component:genomic-ref-seq SΣ 0..1 BackboneElement Genomic Reference Sequence
    ..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
    ..... code SΣ 1..1 CodeableConcept 48013-7
    Binding: LOINCCodes (example): Codes identifying names of simple observations.


    Required Pattern: At least the following
    ...... coding 1..* Coding Code defined by a terminology system
    Fixed Value: (complex)
    ....... system 1..1 uri Identity of the terminology system
    Fixed Value: http://loinc.org
    ....... code 1..1 code Symbol in syntax defined by the system
    Fixed Value: 48013-7
    ..... value[x] SΣ 1..1 CodeableConcept Versioned genomic reference sequence identifier.
    Binding: (unbound) (example): Multiple bindings acceptable (NCBI or LRG)

    .... component:uncallable-regions Σ 0..* BackboneElement Uncallable Sub-regions
    ..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
    ..... code Σ 1..1 CodeableConcept uncallable-regions
    Binding: LOINCCodes (example): Codes identifying names of simple observations.


    Required Pattern: At least the following
    ...... coding 1..* Coding Code defined by a terminology system
    Fixed Value: (complex)
    ....... system 1..1 uri Identity of the terminology system
    Fixed Value: http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs
    ....... code 1..1 code Symbol in syntax defined by the system
    Fixed Value: uncallable-regions

    doco Documentation for this format

    Terminology Bindings

    PathConformanceValueSet / CodeURI
    Observation.statusrequiredObservationStatus
    http://hl7.org/fhir/ValueSet/observation-status|4.0.1
    from the FHIR Standard
    Observation.categorypreferredObservationCategoryCodes
    http://hl7.org/fhir/ValueSet/observation-category
    from the FHIR Standard
    Observation.category:labCategorypreferredPattern: laboratory
    http://hl7.org/fhir/ValueSet/observation-category
    from the FHIR Standard
    Observation.codeexamplePattern: LOINC code 53041-0
    http://hl7.org/fhir/ValueSet/observation-codes
    from the FHIR Standard
    Observation.dataAbsentReasonextensibleDataAbsentReason
    http://hl7.org/fhir/ValueSet/data-absent-reason
    from the FHIR Standard
    Observation.component.codeexampleLOINCCodes (a valid code from LOINC)
    http://hl7.org/fhir/ValueSet/observation-codes
    from the FHIR Standard
    Observation.component:conclusion-string.codeexamplePattern: conclusion-string
    http://hl7.org/fhir/ValueSet/observation-codes
    from the FHIR Standard
    Observation.component:gene-studied.codeexamplePattern: LOINC code 48018-6
    http://hl7.org/fhir/ValueSet/observation-codes
    from the FHIR Standard
    Observation.component:gene-studied.value[x]extensibleHGNCVS
    http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs
    Observation.component:gene-mutations.codeexamplePattern: LOINC code 36908-2
    http://hl7.org/fhir/ValueSet/observation-codes
    from the FHIR Standard
    Observation.component:gene-mutations.value[x]requiredHGVSVS
    http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgvs-vs
    Observation.component:region-description.codeexamplePattern: LOINC code 81293-3
    http://hl7.org/fhir/ValueSet/observation-codes
    from the FHIR Standard
    Observation.component:region-coverage.codeexamplePattern: region-coverage
    http://hl7.org/fhir/ValueSet/observation-codes
    from the FHIR Standard
    Observation.component:ranges-examined.codeexamplePattern: LOINC code 51959-5
    http://hl7.org/fhir/ValueSet/observation-codes
    from the FHIR Standard
    Observation.component:coordinate-system.codeexamplePattern: LOINC code 92822-6
    http://hl7.org/fhir/ValueSet/observation-codes
    from the FHIR Standard
    Observation.component:coordinate-system.value[x]extensibleLOINC LL5323-2
    http://loinc.org/vs/LL5323-2
    Observation.component:genomic-ref-seq.codeexamplePattern: LOINC code 48013-7
    http://hl7.org/fhir/ValueSet/observation-codes
    from the FHIR Standard
    Observation.component:genomic-ref-seq.value[x]example
    Observation.component:uncallable-regions.codeexamplePattern: uncallable-regions
    http://hl7.org/fhir/ValueSet/observation-codes
    from the FHIR Standard
    NameFlagsCard.TypeDescription & Constraintsdoco
    .. Observation C 0..* RegionStudied Region Studied
    obs-6: dataAbsentReason SHALL only be present if Observation.value[x] is not present
    obs-7: If Observation.code is the same as an Observation.component.code then the value element associated with the code SHALL NOT be present
    ... id Σ 0..1 id Logical id of this artifact
    ... meta Σ 0..1 Meta Metadata about the resource
    ... implicitRules ?!Σ 0..1 uri A set of rules under which this content was created
    ... language 0..1 code Language of the resource content
    Binding: CommonLanguages (preferred): A human language.

    Additional BindingsPurpose
    AllLanguages Max Binding
    ... text 0..1 Narrative Text summary of the resource, for human interpretation
    ... contained 0..* Resource Contained, inline Resources
    ... Slices for extension 0..* Extension Extension
    Slice: Unordered, Open by value:url
    ... secondary-finding 0..1 CodeableConcept Secondary findings are genetic test results that provide information about variants in a gene unrelated to the primary purpose for the testing, most often discovered when [Whole Exome Sequencing (WES)](https://en.wikipedia.org/wiki/Exome_sequencing) or [Whole Genome Sequencing (WGS)](https://en.wikipedia.org/wiki/Whole_genome_sequencing) is performed. This extension should be used to denote when a genetic finding is being shared as a secondary finding, and ideally refer to a corresponding guideline or policy statement. For more detail, please see: https://ghr.nlm.nih.gov/primer/testing/secondaryfindings
    URL: http://hl7.org/fhir/StructureDefinition/observation-secondaryFinding
    Binding: GeneticObservationSecondaryFindings (extensible): Codes to denote a guideline or policy statement when a genetic test result is being shared as a secondary finding.


    ... body-structure 0..1 Reference(BodyStructure) Target anatomic location or structure
    URL: http://hl7.org/fhir/StructureDefinition/bodySite
    ... modifierExtension ?! 0..* Extension Extensions that cannot be ignored
    ... identifier Σ 0..* Identifier Business Identifier for observation
    ... basedOn Σ 0..* Reference(CarePlan | DeviceRequest | ImmunizationRecommendation | MedicationRequest | NutritionOrder | ServiceRequest) Fulfills plan, proposal or order
    ... partOf Σ 0..* Reference(MedicationAdministration | MedicationDispense | MedicationStatement | Procedure | Immunization | ImagingStudy) Part of referenced event
    ... status ?!SΣ 1..1 code registered | preliminary | final | amended +
    Binding: ObservationStatus (required): Codes providing the status of an observation.

    ... Slices for category S 1..* CodeableConcept Classification of type of observation
    Slice: Unordered, Open by value:coding
    Binding: ObservationCategoryCodes (preferred): Codes for high level observation categories.


    .... category:labCategory 1..1 CodeableConcept Classification of type of observation
    Binding: ObservationCategoryCodes (preferred): Codes for high level observation categories.



    Required Pattern: At least the following
    ..... id 0..1 string Unique id for inter-element referencing
    ..... extension 0..* Extension Additional content defined by implementations
    ..... coding 1..* Coding Code defined by a terminology system
    Fixed Value: (complex)
    ...... id 0..1 string Unique id for inter-element referencing
    ...... extension 0..* Extension Additional content defined by implementations
    ...... system 1..1 uri Identity of the terminology system
    Fixed Value: http://terminology.hl7.org/CodeSystem/observation-category
    ...... version 0..1 string Version of the system - if relevant
    ...... code 1..1 code Symbol in syntax defined by the system
    Fixed Value: laboratory
    ...... display 0..1 string Representation defined by the system
    ...... userSelected 0..1 boolean If this coding was chosen directly by the user
    ..... text 0..1 string Plain text representation of the concept
    ..... id 0..1 string Unique id for inter-element referencing
    ..... extension 0..* Extension Additional content defined by implementations
    Slice: Unordered, Open by value:url
    ..... coding Σ 1..1 Coding Code defined by a terminology system

    Required Pattern: At least the following
    ...... id 0..1 string Unique id for inter-element referencing
    ...... extension 0..* Extension Additional content defined by implementations
    ...... system 1..1 uri Identity of the terminology system
    Fixed Value: http://terminology.hl7.org/CodeSystem/observation-category
    ...... version 0..1 string Version of the system - if relevant
    ...... code 1..1 code Symbol in syntax defined by the system
    Fixed Value: laboratory
    ...... display 0..1 string Representation defined by the system
    ...... userSelected 0..1 boolean If this coding was chosen directly by the user
    ..... text Σ 0..1 string Plain text representation of the concept
    ... code SΣ 1..1 CodeableConcept 53041-0
    Binding: LOINCCodes (example): Codes identifying names of simple observations.


    Required Pattern: At least the following
    .... id 0..1 string Unique id for inter-element referencing
    .... extension 0..* Extension Additional content defined by implementations
    .... coding 1..* Coding Code defined by a terminology system
    Fixed Value: (complex)
    ..... id 0..1 string Unique id for inter-element referencing
    ..... extension 0..* Extension Additional content defined by implementations
    ..... system 1..1 uri Identity of the terminology system
    Fixed Value: http://loinc.org
    ..... version 0..1 string Version of the system - if relevant
    ..... code 1..1 code Symbol in syntax defined by the system
    Fixed Value: 53041-0
    ..... display 0..1 string Representation defined by the system
    ..... userSelected 0..1 boolean If this coding was chosen directly by the user
    .... text 0..1 string Plain text representation of the concept
    ... subject SΣ 1..1 Reference(Cancer Patient Profile) Who and/or what the observation is about
    ... focus Σ 0..* Reference(Resource) What the observation is about, when it is not about the subject of record
    ... encounter Σ 0..1 Reference(Encounter) Healthcare event during which this observation is made
    ... Slices for effective[x] SΣ 0..1 Clinically relevant time/time-period for observation
    Slice: Unordered, Open by type:$this
    .... effectiveDateTime dateTime
    .... effectivePeriod Period
    .... effectiveTiming Timing
    .... effectiveInstant instant
    .... effective[x]:effectiveDateTime SΣ 0..1 dateTime Clinically relevant time/time-period for observation
    ... issued Σ 0..1 instant Date/Time this version was made available
    ... performer Σ 0..* Reference(Practitioner | PractitionerRole | Organization | CareTeam | Patient | RelatedPerson) Who is responsible for the observation
    ... dataAbsentReason SC 0..1 CodeableConcept Why the result is missing
    Binding: DataAbsentReason (extensible): Codes specifying why the result (Observation.value[x]) is missing.

    ... interpretation 0..* CodeableConcept High, low, normal, etc.
    Binding: ObservationInterpretationCodes (extensible): Codes identifying interpretations of observations.


    ... note 0..* CodedAnnotation Comments about the Observation that also contain a coded type
    ... bodySite 0..1 CodeableConcept Observed body part
    Binding: SNOMEDCTBodyStructures (example): Codes describing anatomical locations. May include laterality.

    ... method 0..1 CodeableConcept How it was done
    Binding: ObservationMethods (example): Methods for simple observations.

    ... specimen 0..1 Reference(Specimen) Specimen used for this observation
    ... device 0..1 Reference(Device | DeviceMetric) (Measurement) Device
    ... referenceRange C 0..* BackboneElement Provides guide for interpretation
    obs-3: Must have at least a low or a high or text
    .... id 0..1 string Unique id for inter-element referencing
    .... extension 0..* Extension Additional content defined by implementations
    .... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
    .... low C 0..1 SimpleQuantity Low Range, if relevant
    .... high C 0..1 SimpleQuantity High Range, if relevant
    .... type 0..1 CodeableConcept Reference range qualifier
    Binding: ObservationReferenceRangeMeaningCodes (preferred): Code for the meaning of a reference range.

    .... appliesTo 0..* CodeableConcept Reference range population
    Binding: ObservationReferenceRangeAppliesToCodes (example): Codes identifying the population the reference range applies to.


    .... age 0..1 Range Applicable age range, if relevant
    .... text 0..1 string Text based reference range in an observation
    ... hasMember Σ 0..* Reference(Observation | QuestionnaireResponse | MolecularSequence) Related resource that belongs to the Observation group
    ... derivedFrom Σ 0..* Reference(DocumentReference | ImagingStudy | Media | QuestionnaireResponse | Observation | MolecularSequence) Related measurements the observation is made from
    ... Slices for component SΣ 0..* BackboneElement Component results
    Slice: Unordered, Open by pattern:code
    .... component:All Slices Content/Rules for all slices
    ..... id 0..1 string Unique id for inter-element referencing
    ..... extension 0..* Extension Additional content defined by implementations
    ..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
    ..... code Σ 1..1 CodeableConcept Type of component observation (code / type)
    Binding: LOINCCodes (example): Codes identifying names of simple observations.

    ..... value[x] Σ 0..1 Actual component result
    ...... valueQuantity Quantity
    ...... valueCodeableConcept CodeableConcept
    ...... valueString string
    ...... valueBoolean boolean
    ...... valueInteger integer
    ...... valueRange Range
    ...... valueRatio Ratio
    ...... valueSampledData SampledData
    ...... valueTime time
    ...... valueDateTime dateTime
    ...... valuePeriod Period
    ..... dataAbsentReason C 0..1 CodeableConcept Why the component result is missing
    Binding: DataAbsentReason (extensible): Codes specifying why the result (Observation.value[x]) is missing.

    ..... interpretation 0..* CodeableConcept High, low, normal, etc.
    Binding: ObservationInterpretationCodes (extensible): Codes identifying interpretations of observations.


    ..... referenceRange 0..* See referenceRange (Observation) Provides guide for interpretation of component result
    .... component:conclusion-string Σ 0..1 BackboneElement Clinical Conclusion
    ..... id 0..1 string Unique id for inter-element referencing
    ..... extension 0..* Extension Additional content defined by implementations
    ..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
    ..... code Σ 1..1 CodeableConcept conclusion-string
    Binding: LOINCCodes (example): Codes identifying names of simple observations.


    Required Pattern: At least the following
    ...... id 0..1 string Unique id for inter-element referencing
    ...... extension 0..* Extension Additional content defined by implementations
    ...... coding 1..* Coding Code defined by a terminology system
    Fixed Value: (complex)
    ....... id 0..1 string Unique id for inter-element referencing
    ....... extension 0..* Extension Additional content defined by implementations
    ....... system 1..1 uri Identity of the terminology system
    Fixed Value: http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs
    ....... version 0..1 string Version of the system - if relevant
    ....... code 1..1 code Symbol in syntax defined by the system
    Fixed Value: conclusion-string
    ....... display 0..1 string Representation defined by the system
    ....... userSelected 0..1 boolean If this coding was chosen directly by the user
    ...... text 0..1 string Plain text representation of the concept
    ..... value[x] Σ 0..1 string Summary conclusion (interpretation/impression)
    ..... dataAbsentReason C 0..1 CodeableConcept Why the component result is missing
    Binding: DataAbsentReason (extensible): Codes specifying why the result (Observation.value[x]) is missing.

    ..... interpretation 0..* CodeableConcept High, low, normal, etc.
    Binding: ObservationInterpretationCodes (extensible): Codes identifying interpretations of observations.


    ..... referenceRange 0..* See referenceRange (Observation) Provides guide for interpretation of component result
    .... component:gene-studied SΣ 0..1 BackboneElement Gene Studied
    ..... id 0..1 string Unique id for inter-element referencing
    ..... extension 0..* Extension Additional content defined by implementations
    ..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
    ..... code SΣ 1..1 CodeableConcept 48018-6
    Binding: LOINCCodes (example): Codes identifying names of simple observations.


    Required Pattern: At least the following
    ...... id 0..1 string Unique id for inter-element referencing
    ...... extension 0..* Extension Additional content defined by implementations
    ...... coding 1..* Coding Code defined by a terminology system
    Fixed Value: (complex)
    ....... id 0..1 string Unique id for inter-element referencing
    ....... extension 0..* Extension Additional content defined by implementations
    ....... system 1..1 uri Identity of the terminology system
    Fixed Value: http://loinc.org
    ....... version 0..1 string Version of the system - if relevant
    ....... code 1..1 code Symbol in syntax defined by the system
    Fixed Value: 48018-6
    ....... display 0..1 string Representation defined by the system
    ....... userSelected 0..1 boolean If this coding was chosen directly by the user
    ...... text 0..1 string Plain text representation of the concept
    ..... value[x] SΣ 1..1 CodeableConcept The HGNC gene symbol is to be used as display text and the HGNC gene ID used as the code. If no HGNC code issued for this gene yet, NCBI gene IDs SHALL be used.
    Binding: HUGO Gene Nomenclature Committee Gene Names (HGNC) (extensible)
    ..... dataAbsentReason C 0..1 CodeableConcept Why the component result is missing
    Binding: DataAbsentReason (extensible): Codes specifying why the result (Observation.value[x]) is missing.

    ..... interpretation 0..* CodeableConcept High, low, normal, etc.
    Binding: ObservationInterpretationCodes (extensible): Codes identifying interpretations of observations.


    ..... referenceRange 0..* See referenceRange (Observation) Provides guide for interpretation of component result
    .... component:gene-mutations SΣ 0..1 BackboneElement Gene Mutations ID
    ..... id 0..1 string Unique id for inter-element referencing
    ..... extension 0..* Extension Additional content defined by implementations
    ..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
    ..... code SΣ 1..1 CodeableConcept 36908-2
    Binding: LOINCCodes (example): Codes identifying names of simple observations.


    Required Pattern: At least the following
    ...... id 0..1 string Unique id for inter-element referencing
    ...... extension 0..* Extension Additional content defined by implementations
    ...... coding 1..* Coding Code defined by a terminology system
    Fixed Value: (complex)
    ....... id 0..1 string Unique id for inter-element referencing
    ....... extension 0..* Extension Additional content defined by implementations
    ....... system 1..1 uri Identity of the terminology system
    Fixed Value: http://loinc.org
    ....... version 0..1 string Version of the system - if relevant
    ....... code 1..1 code Symbol in syntax defined by the system
    Fixed Value: 36908-2
    ....... display 0..1 string Representation defined by the system
    ....... userSelected 0..1 boolean If this coding was chosen directly by the user
    ...... text 0..1 string Plain text representation of the concept
    ..... value[x] SΣ 1..1 CodeableConcept Actual component result
    Binding: Human Genome Variation Society (HGVS) Nomenclature (required)
    ..... dataAbsentReason C 0..1 CodeableConcept Why the component result is missing
    Binding: DataAbsentReason (extensible): Codes specifying why the result (Observation.value[x]) is missing.

    ..... interpretation 0..* CodeableConcept High, low, normal, etc.
    Binding: ObservationInterpretationCodes (extensible): Codes identifying interpretations of observations.


    ..... referenceRange 0..* See referenceRange (Observation) Provides guide for interpretation of component result
    .... component:region-description SΣ 0..1 BackboneElement Region Description
    ..... id 0..1 string Unique id for inter-element referencing
    ..... extension 0..* Extension Additional content defined by implementations
    ..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
    ..... code SΣ 1..1 CodeableConcept 81293-3
    Binding: LOINCCodes (example): Codes identifying names of simple observations.


    Required Pattern: At least the following
    ...... id 0..1 string Unique id for inter-element referencing
    ...... extension 0..* Extension Additional content defined by implementations
    ...... coding 1..* Coding Code defined by a terminology system
    Fixed Value: (complex)
    ....... id 0..1 string Unique id for inter-element referencing
    ....... extension 0..* Extension Additional content defined by implementations
    ....... system 1..1 uri Identity of the terminology system
    Fixed Value: http://loinc.org
    ....... version 0..1 string Version of the system - if relevant
    ....... code 1..1 code Symbol in syntax defined by the system
    Fixed Value: 81293-3
    ....... display 0..1 string Representation defined by the system
    ....... userSelected 0..1 boolean If this coding was chosen directly by the user
    ...... text 0..1 string Plain text representation of the concept
    ..... value[x] SΣ 0..1 string Actual component result
    ..... dataAbsentReason C 0..1 CodeableConcept Why the component result is missing
    Binding: DataAbsentReason (extensible): Codes specifying why the result (Observation.value[x]) is missing.

    ..... interpretation 0..* CodeableConcept High, low, normal, etc.
    Binding: ObservationInterpretationCodes (extensible): Codes identifying interpretations of observations.


    ..... referenceRange 0..* See referenceRange (Observation) Provides guide for interpretation of component result
    .... component:region-coverage Σ 0..1 BackboneElement Region Coverage
    ..... id 0..1 string Unique id for inter-element referencing
    ..... extension 0..* Extension Additional content defined by implementations
    ..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
    ..... code Σ 1..1 CodeableConcept region-coverage
    Binding: LOINCCodes (example): Codes identifying names of simple observations.


    Required Pattern: At least the following
    ...... id 0..1 string Unique id for inter-element referencing
    ...... extension 0..* Extension Additional content defined by implementations
    ...... coding 1..* Coding Code defined by a terminology system
    Fixed Value: (complex)
    ....... id 0..1 string Unique id for inter-element referencing
    ....... extension 0..* Extension Additional content defined by implementations
    ....... system 1..1 uri Identity of the terminology system
    Fixed Value: http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs
    ....... version 0..1 string Version of the system - if relevant
    ....... code 1..1 code Symbol in syntax defined by the system
    Fixed Value: region-coverage
    ....... display 0..1 string Representation defined by the system
    ....... userSelected 0..1 boolean If this coding was chosen directly by the user
    ...... text 0..1 string Plain text representation of the concept
    ..... value[x] Σ 0..1 Quantity Actual component result
    ..... dataAbsentReason C 0..1 CodeableConcept Why the component result is missing
    Binding: DataAbsentReason (extensible): Codes specifying why the result (Observation.value[x]) is missing.

    ..... interpretation 0..* CodeableConcept High, low, normal, etc.
    Binding: ObservationInterpretationCodes (extensible): Codes identifying interpretations of observations.


    ..... referenceRange 0..* See referenceRange (Observation) Provides guide for interpretation of component result
    .... component:ranges-examined SΣ 0..* BackboneElement Range(s) of DNA sequence examined
    ..... id 0..1 string Unique id for inter-element referencing
    ..... extension 0..* Extension Additional content defined by implementations
    ..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
    ..... code SΣ 1..1 CodeableConcept 51959-5
    Binding: LOINCCodes (example): Codes identifying names of simple observations.


    Required Pattern: At least the following
    ...... id 0..1 string Unique id for inter-element referencing
    ...... extension 0..* Extension Additional content defined by implementations
    ...... coding 1..* Coding Code defined by a terminology system
    Fixed Value: (complex)
    ....... id 0..1 string Unique id for inter-element referencing
    ....... extension 0..* Extension Additional content defined by implementations
    ....... system 1..1 uri Identity of the terminology system
    Fixed Value: http://loinc.org
    ....... version 0..1 string Version of the system - if relevant
    ....... code 1..1 code Symbol in syntax defined by the system
    Fixed Value: 51959-5
    ....... display 0..1 string Representation defined by the system
    ....... userSelected 0..1 boolean If this coding was chosen directly by the user
    ...... text 0..1 string Plain text representation of the concept
    ..... value[x] SΣ 0..1 Range Actual component result
    ..... dataAbsentReason C 0..1 CodeableConcept Why the component result is missing
    Binding: DataAbsentReason (extensible): Codes specifying why the result (Observation.value[x]) is missing.

    ..... interpretation 0..* CodeableConcept High, low, normal, etc.
    Binding: ObservationInterpretationCodes (extensible): Codes identifying interpretations of observations.


    ..... referenceRange 0..* See referenceRange (Observation) Provides guide for interpretation of component result
    .... component:coordinate-system SΣ 0..1 BackboneElement Coordinate System
    ..... id 0..1 string Unique id for inter-element referencing
    ..... extension 0..* Extension Additional content defined by implementations
    ..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
    ..... code SΣ 1..1 CodeableConcept 92822-6
    Binding: LOINCCodes (example): Codes identifying names of simple observations.


    Required Pattern: At least the following
    ...... id 0..1 string Unique id for inter-element referencing
    ...... extension 0..* Extension Additional content defined by implementations
    ...... coding 1..* Coding Code defined by a terminology system
    Fixed Value: (complex)
    ....... id 0..1 string Unique id for inter-element referencing
    ....... extension 0..* Extension Additional content defined by implementations
    ....... system 1..1 uri Identity of the terminology system
    Fixed Value: http://loinc.org
    ....... version 0..1 string Version of the system - if relevant
    ....... code 1..1 code Symbol in syntax defined by the system
    Fixed Value: 92822-6
    ....... display 0..1 string Representation defined by the system
    ....... userSelected 0..1 boolean If this coding was chosen directly by the user
    ...... text 0..1 string Plain text representation of the concept
    ..... value[x] SΣ 1..1 CodeableConcept 0-based interval counting | 0-based character counting | 1-based character counting
    Binding: LOINC Answer List LL5323-2 (extensible)
    ..... dataAbsentReason C 0..1 CodeableConcept Why the component result is missing
    Binding: DataAbsentReason (extensible): Codes specifying why the result (Observation.value[x]) is missing.

    ..... interpretation 0..* CodeableConcept High, low, normal, etc.
    Binding: ObservationInterpretationCodes (extensible): Codes identifying interpretations of observations.


    ..... referenceRange 0..* See referenceRange (Observation) Provides guide for interpretation of component result
    .... component:genomic-ref-seq SΣ 0..1 BackboneElement Genomic Reference Sequence
    ..... id 0..1 string Unique id for inter-element referencing
    ..... extension 0..* Extension Additional content defined by implementations
    ..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
    ..... code SΣ 1..1 CodeableConcept 48013-7
    Binding: LOINCCodes (example): Codes identifying names of simple observations.


    Required Pattern: At least the following
    ...... id 0..1 string Unique id for inter-element referencing
    ...... extension 0..* Extension Additional content defined by implementations
    ...... coding 1..* Coding Code defined by a terminology system
    Fixed Value: (complex)
    ....... id 0..1 string Unique id for inter-element referencing
    ....... extension 0..* Extension Additional content defined by implementations
    ....... system 1..1 uri Identity of the terminology system
    Fixed Value: http://loinc.org
    ....... version 0..1 string Version of the system - if relevant
    ....... code 1..1 code Symbol in syntax defined by the system
    Fixed Value: 48013-7
    ....... display 0..1 string Representation defined by the system
    ....... userSelected 0..1 boolean If this coding was chosen directly by the user
    ...... text 0..1 string Plain text representation of the concept
    ..... value[x] SΣ 1..1 CodeableConcept Versioned genomic reference sequence identifier.
    Binding: (unbound) (example): Multiple bindings acceptable (NCBI or LRG)

    ..... dataAbsentReason C 0..1 CodeableConcept Why the component result is missing
    Binding: DataAbsentReason (extensible): Codes specifying why the result (Observation.value[x]) is missing.

    ..... interpretation 0..* CodeableConcept High, low, normal, etc.
    Binding: ObservationInterpretationCodes (extensible): Codes identifying interpretations of observations.


    ..... referenceRange 0..* See referenceRange (Observation) Provides guide for interpretation of component result
    .... component:uncallable-regions Σ 0..* BackboneElement Uncallable Sub-regions
    ..... id 0..1 string Unique id for inter-element referencing
    ..... extension 0..* Extension Additional content defined by implementations
    ..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
    ..... code Σ 1..1 CodeableConcept uncallable-regions
    Binding: LOINCCodes (example): Codes identifying names of simple observations.


    Required Pattern: At least the following
    ...... id 0..1 string Unique id for inter-element referencing
    ...... extension 0..* Extension Additional content defined by implementations
    ...... coding 1..* Coding Code defined by a terminology system
    Fixed Value: (complex)
    ....... id 0..1 string Unique id for inter-element referencing
    ....... extension 0..* Extension Additional content defined by implementations
    ....... system 1..1 uri Identity of the terminology system
    Fixed Value: http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs
    ....... version 0..1 string Version of the system - if relevant
    ....... code 1..1 code Symbol in syntax defined by the system
    Fixed Value: uncallable-regions
    ....... display 0..1 string Representation defined by the system
    ....... userSelected 0..1 boolean If this coding was chosen directly by the user
    ...... text 0..1 string Plain text representation of the concept
    ..... value[x] Σ 0..1 Range Must be inside the range given by 'ranges examined' in the given reference sequence and coordinate system.
    ..... dataAbsentReason C 0..1 CodeableConcept Why the component result is missing
    Binding: DataAbsentReason (extensible): Codes specifying why the result (Observation.value[x]) is missing.

    ..... interpretation 0..* CodeableConcept High, low, normal, etc.
    Binding: ObservationInterpretationCodes (extensible): Codes identifying interpretations of observations.


    ..... referenceRange 0..* See referenceRange (Observation) Provides guide for interpretation of component result

    doco Documentation for this format

    Terminology Bindings

    PathConformanceValueSet / CodeURI
    Observation.languagepreferredCommonLanguages
    Additional Bindings Purpose
    AllLanguages Max Binding
    http://hl7.org/fhir/ValueSet/languages
    from the FHIR Standard
    Observation.statusrequiredObservationStatus
    http://hl7.org/fhir/ValueSet/observation-status|4.0.1
    from the FHIR Standard
    Observation.categorypreferredObservationCategoryCodes
    http://hl7.org/fhir/ValueSet/observation-category
    from the FHIR Standard
    Observation.category:labCategorypreferredPattern: laboratory
    http://hl7.org/fhir/ValueSet/observation-category
    from the FHIR Standard
    Observation.codeexamplePattern: LOINC code 53041-0
    http://hl7.org/fhir/ValueSet/observation-codes
    from the FHIR Standard
    Observation.dataAbsentReasonextensibleDataAbsentReason
    http://hl7.org/fhir/ValueSet/data-absent-reason
    from the FHIR Standard
    Observation.interpretationextensibleObservationInterpretationCodes
    http://hl7.org/fhir/ValueSet/observation-interpretation
    from the FHIR Standard
    Observation.bodySiteexampleSNOMEDCTBodyStructures
    http://hl7.org/fhir/ValueSet/body-site
    from the FHIR Standard
    Observation.methodexampleObservationMethods
    http://hl7.org/fhir/ValueSet/observation-methods
    from the FHIR Standard
    Observation.referenceRange.typepreferredObservationReferenceRangeMeaningCodes
    http://hl7.org/fhir/ValueSet/referencerange-meaning
    from the FHIR Standard
    Observation.referenceRange.appliesToexampleObservationReferenceRangeAppliesToCodes
    http://hl7.org/fhir/ValueSet/referencerange-appliesto
    from the FHIR Standard
    Observation.component.codeexampleLOINCCodes (a valid code from LOINC)
    http://hl7.org/fhir/ValueSet/observation-codes
    from the FHIR Standard
    Observation.component.dataAbsentReasonextensibleDataAbsentReason
    http://hl7.org/fhir/ValueSet/data-absent-reason
    from the FHIR Standard
    Observation.component.interpretationextensibleObservationInterpretationCodes
    http://hl7.org/fhir/ValueSet/observation-interpretation
    from the FHIR Standard
    Observation.component:conclusion-string.codeexamplePattern: conclusion-string
    http://hl7.org/fhir/ValueSet/observation-codes
    from the FHIR Standard
    Observation.component:conclusion-string.dataAbsentReasonextensibleDataAbsentReason
    http://hl7.org/fhir/ValueSet/data-absent-reason
    from the FHIR Standard
    Observation.component:conclusion-string.interpretationextensibleObservationInterpretationCodes
    http://hl7.org/fhir/ValueSet/observation-interpretation
    from the FHIR Standard
    Observation.component:gene-studied.codeexamplePattern: LOINC code 48018-6
    http://hl7.org/fhir/ValueSet/observation-codes
    from the FHIR Standard
    Observation.component:gene-studied.value[x]extensibleHGNCVS
    http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs
    Observation.component:gene-studied.dataAbsentReasonextensibleDataAbsentReason
    http://hl7.org/fhir/ValueSet/data-absent-reason
    from the FHIR Standard
    Observation.component:gene-studied.interpretationextensibleObservationInterpretationCodes
    http://hl7.org/fhir/ValueSet/observation-interpretation
    from the FHIR Standard
    Observation.component:gene-mutations.codeexamplePattern: LOINC code 36908-2
    http://hl7.org/fhir/ValueSet/observation-codes
    from the FHIR Standard
    Observation.component:gene-mutations.value[x]requiredHGVSVS
    http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgvs-vs
    Observation.component:gene-mutations.dataAbsentReasonextensibleDataAbsentReason
    http://hl7.org/fhir/ValueSet/data-absent-reason
    from the FHIR Standard
    Observation.component:gene-mutations.interpretationextensibleObservationInterpretationCodes
    http://hl7.org/fhir/ValueSet/observation-interpretation
    from the FHIR Standard
    Observation.component:region-description.codeexamplePattern: LOINC code 81293-3
    http://hl7.org/fhir/ValueSet/observation-codes
    from the FHIR Standard
    Observation.component:region-description.dataAbsentReasonextensibleDataAbsentReason
    http://hl7.org/fhir/ValueSet/data-absent-reason
    from the FHIR Standard
    Observation.component:region-description.interpretationextensibleObservationInterpretationCodes
    http://hl7.org/fhir/ValueSet/observation-interpretation
    from the FHIR Standard
    Observation.component:region-coverage.codeexamplePattern: region-coverage
    http://hl7.org/fhir/ValueSet/observation-codes
    from the FHIR Standard
    Observation.component:region-coverage.dataAbsentReasonextensibleDataAbsentReason
    http://hl7.org/fhir/ValueSet/data-absent-reason
    from the FHIR Standard
    Observation.component:region-coverage.interpretationextensibleObservationInterpretationCodes
    http://hl7.org/fhir/ValueSet/observation-interpretation
    from the FHIR Standard
    Observation.component:ranges-examined.codeexamplePattern: LOINC code 51959-5
    http://hl7.org/fhir/ValueSet/observation-codes
    from the FHIR Standard
    Observation.component:ranges-examined.dataAbsentReasonextensibleDataAbsentReason
    http://hl7.org/fhir/ValueSet/data-absent-reason
    from the FHIR Standard
    Observation.component:ranges-examined.interpretationextensibleObservationInterpretationCodes
    http://hl7.org/fhir/ValueSet/observation-interpretation
    from the FHIR Standard
    Observation.component:coordinate-system.codeexamplePattern: LOINC code 92822-6
    http://hl7.org/fhir/ValueSet/observation-codes
    from the FHIR Standard
    Observation.component:coordinate-system.value[x]extensibleLOINC LL5323-2
    http://loinc.org/vs/LL5323-2
    Observation.component:coordinate-system.dataAbsentReasonextensibleDataAbsentReason
    http://hl7.org/fhir/ValueSet/data-absent-reason
    from the FHIR Standard
    Observation.component:coordinate-system.interpretationextensibleObservationInterpretationCodes
    http://hl7.org/fhir/ValueSet/observation-interpretation
    from the FHIR Standard
    Observation.component:genomic-ref-seq.codeexamplePattern: LOINC code 48013-7
    http://hl7.org/fhir/ValueSet/observation-codes
    from the FHIR Standard
    Observation.component:genomic-ref-seq.value[x]example
    Observation.component:genomic-ref-seq.dataAbsentReasonextensibleDataAbsentReason
    http://hl7.org/fhir/ValueSet/data-absent-reason
    from the FHIR Standard
    Observation.component:genomic-ref-seq.interpretationextensibleObservationInterpretationCodes
    http://hl7.org/fhir/ValueSet/observation-interpretation
    from the FHIR Standard
    Observation.component:uncallable-regions.codeexamplePattern: uncallable-regions
    http://hl7.org/fhir/ValueSet/observation-codes
    from the FHIR Standard
    Observation.component:uncallable-regions.dataAbsentReasonextensibleDataAbsentReason
    http://hl7.org/fhir/ValueSet/data-absent-reason
    from the FHIR Standard
    Observation.component:uncallable-regions.interpretationextensibleObservationInterpretationCodes
    http://hl7.org/fhir/ValueSet/observation-interpretation
    from the FHIR Standard

    This structure is derived from RegionStudied

    Summary

    Mandatory: 1 element
    Must-Support: 26 elements

    Structures

    This structure refers to these other structures:

    Slices

    This structure defines the following Slices:

    • The element 1 is sliced based on the value of Observation.effective[x]

    Maturity: 1

    Differential View

    This structure is derived from RegionStudied

    NameFlagsCard.TypeDescription & Constraintsdoco
    .. Observation 0..* RegionStudied Region Studied
    ... status S 1..1 code registered | preliminary | final | amended +
    ... category S 1..* CodeableConcept Classification of type of observation
    ... category:labCategory 1..1 CodeableConcept Classification of type of observation
    Required Pattern: At least the following
    .... coding 1..* Coding Code defined by a terminology system
    Fixed Value: (complex)
    ..... system 1..1 uri Identity of the terminology system
    Fixed Value: http://terminology.hl7.org/CodeSystem/observation-category
    ..... code 1..1 code Symbol in syntax defined by the system
    Fixed Value: laboratory
    .... coding 1..1 Coding Code defined by a terminology system
    ... subject S 1..1 Reference(Cancer Patient Profile) Who and/or what the observation is about
    ... Slices for effective[x] S 0..1 dateTime, Period, Timing, instant Clinically relevant time/time-period for observation
    Slice: Unordered, Open by type:$this
    .... effective[x]:effectiveDateTime S 0..1 dateTime Clinically relevant time/time-period for observation
    ... value[x] 0..0 Quantity, CodeableConcept, string, boolean, integer, Range, Ratio, SampledData, time, dateTime, Period
    ... dataAbsentReason S 0..1 CodeableConcept Why the result is missing
    ... component S 0..* BackboneElement Component results
    ... component:gene-studied S 0..1 BackboneElement Gene Studied
    .... code S 1..1 CodeableConcept 48018-6
    .... value[x] S 1..1 CodeableConcept The HGNC gene symbol is to be used as display text and the HGNC gene ID used as the code. If no HGNC code issued for this gene yet, NCBI gene IDs SHALL be used.
    ... component:gene-mutations S 0..1 BackboneElement Gene Mutations ID
    .... code S 1..1 CodeableConcept 36908-2
    .... value[x] S 1..1 CodeableConcept Actual component result
    ... component:region-description S 0..1 BackboneElement Region Description
    .... code S 1..1 CodeableConcept 81293-3
    .... value[x] S 0..1 string Actual component result
    ... component:ranges-examined S 0..* BackboneElement Range(s) of DNA sequence examined
    .... code S 1..1 CodeableConcept 51959-5
    .... value[x] S 0..1 Range Actual component result
    ... component:coordinate-system S 0..1 BackboneElement Coordinate System
    .... code S 1..1 CodeableConcept 92822-6
    .... value[x] S 1..1 CodeableConcept 0-based interval counting | 0-based character counting | 1-based character counting
    ... component:genomic-ref-seq S 0..1 BackboneElement Genomic Reference Sequence
    .... code S 1..1 CodeableConcept 48013-7
    .... value[x] S 1..1 CodeableConcept Versioned genomic reference sequence identifier.

    doco Documentation for this format