minimal Common Oncology Data Elements (mCODE) Implementation Guide
3.0.0-ballot - 2023May United States of America flag

minimal Common Oncology Data Elements (mCODE) Implementation Guide, published by HL7 International Clinical Interoperability Council. This is not an authorized publication; it is the continuous build for version 3.0.0-ballot). This version is based on the current content of and changes regularly. See the Directory of published versions


This implementation guide draws on a number of formal terminologies (code systems). Several guiding principles were applied in selecting terminologies for mCODE:

  1. Fit for purpose
  2. Conformance with US Core and FHIR
  3. Commonly used in real world practice

The following table presents the external code systems (and naming conventions) adopted in mCODE, and their primary purpose:

Code System Application FHIR IG Publishing support? HL7 Canonical [1] Proposed HTA, if different [2]
CPT Procedure codes No  
HGNC Gene identification No  
HGVS Sequence variant nomenclature Yes OID: 2.16.840.1.113883.6.282
HTA Various HL7 V2 and FHIR-specific codes Yes  
ICD-O-3 Cancer morphology and topology codes No  
ICD-10-CM Diagnosis codes Yes  
ICD-10-PCS Procedure codes No  
LOINC Observation and laboratory codes, answer codes Yes  
NCBI GTR Genomic test codes No Missing
NCBI ClinVar Genomic variations No Missing Missing
NCIT Cancer terminology No
RxNorm Medication codes Yes  
Sequence Ontology DNA change types No Missing
SNOMED CT Disorders, body structures, findings, qualifiers Yes  
UCUM Units of measure Yes  

[1] Official HL7 Terminology (v4.0.1: Release)

[2] HL7 Terminology Authority Recommendation (as of 1 Nov 2021)


  • CPT - Current Procedural Terminology (American Medical Association)
  • HGNC - Human Genome Organisation (HUGO) Gene Nomenclature Committee
  • HGVS - Human Genome Variation Society
  • HTA - HL7 Terminology Authority
  • ICD - International Classification of Diseases (World Health Organization)
    • ICD-O-3 - Oncology, 3rd revision
    • ICD-10-CM - Clinical Modification, 10th revision
    • ICD-10-PCS - Procedure Coding System, 10th revision
  • LOINC - Logical Observation Identifiers Names and Codes
  • NCBI - National Center for Biotechnology Information (National Institutes of Health) (US)
    • NCBI GTR - Genomic Testing Registry
    • NCBI ClinVar - Not an acronym
  • NCIT - National Cancer Institute Thesaurus
  • RxNorm - From National Library of Medicine (US)
  • SNOMED CT - Systematized Nomenclature of Medicine Clinical Terms
  • UCUM - Unified Code for Units of Measure
  • UMLS - Unified Medical Language System Metathesaurus

Local Code Systems

Local code systems SnomedRequestedCS are provided for terms submitted but not yet published and/or approved by SNOMED. It is expected that the local codes will be replaced with approved LOINC and SNOMED terms in a future technical correction to the STU 2 IG. Where codes have already been assigned by SNOMED, but not yet published, those codes are used as local codes to reduce future changes. In other cases, the submission numbers are used as the local codes.