IDEA4RC FHIR Implementation Guide
0.1.0 - CI Build 150

IDEA4RC FHIR Implementation Guide, published by IDEA4RC Project. This guide is not an authorized publication; it is the continuous build for version 0.1.0 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/hl7-eu/idea4rc/ and changes regularly. See the Directory of published versions

Logical Model: PathologicalStageI4RC - Detailed Descriptions

Draft as of 2025-07-25

Definitions for the PathologicalStage logical model.

Guidance on how to interpret the contents of this table can be foundhere

0. PathologicalStage
Definition

Pathological Stage Maturity Level: 0 Draft

ShortPathological Stage
Control0..*
Is Modifierfalse
Logical ModelInstances of this logical model are not marked to be the target of a Reference
2. PathologicalStage.diagnosisReference
Definition

Diagnosis element containing the data regarding the patient's cancer

ShortDiagnosis Reference (M)
Control1..*
Typehttp://hl7.eu/fhir/ig/idea4rc/StructureDefinition/Diagnosis
Obligations
    ObligationsActor
    SHALL:handleHead and Neck
    SHALL:handleSarcoma
    4. PathologicalStage.stagingProceduresDoneBy
    Definition

    Describes the ID of the institution where staging procedure for primary tumour was performed

    ShortStaging procedures done by (M)
    Control1..*
    Typestring
    Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
    Obligations
      ObligationsActor
      SHALL:handleHead and Neck
      6. PathologicalStage.pt
      Definition

      Specifies the pathological T

      ShortpT (M)
      Comments

      AJCC/UICC 6th pathological TX Category - 1634270 AJCC/UICC 7th pathological TX Category - 1635402 AJCC/UICC 8th pathological TX Category - 1634986

      AJCC/UICC 6th Tis Category - 1635660 AJCC/UICC 7th Tis Category - 1633798 AJCC/UICC 8th Tis Category - 1634720

      AJCC/UICC 6th pathological T0 Category - 1633279 AJCC/UICC 7th pathological T0 Category - 1634675 AJCC/UICC 8th pathological T0 Category - 1634635

      AJCC/UICC 6th pathological T1 Category - 1633445 AJCC/UICC 7th pathological T1 Category - 1635422 AJCC/UICC 8th pathological T1 Category - 1635070

      AJCC/UICC 6th pathological T2 Category - 1634792 AJCC/UICC 7th pathological T2 Category - 1634491 AJCC/UICC 8th pathological T2 Category - 1633307

      AJCC/UICC 6th pathological T3 Category - 1635670 AJCC/UICC 7th pathological T3 Category - 1634658 AJCC/UICC 8th pathological T3 Category - 1634386

      AJCC/UICC 6th pathological T4 Category - 1635311 AJCC/UICC 7th pathological T4 Category - 1635341 AJCC/UICC 8th pathological T4 Category - 1635396

      AJCC/UICC 6th pathological T4a Category - 1634101 AJCC/UICC 7th pathological T4a Category - 1633723 AJCC/UICC 8th pathological T4a Category - 1634894

      AJCC/UICC 6th pathological T4b Category - 1633900 AJCC/UICC 7th pathological T4b Category - 1633699 AJCC/UICC 8th pathological T4b Category - 1633658

      Control1..*
      TypeCodeableConcept
      Obligations
        ObligationsActor
        SHALL:handleHead and Neck
        8. PathologicalStage.pn
        Definition

        Specifies the pathological N

        ShortpN (M)
        Comments

        AJCC/UICC 6th pathological NX Category - 1635823 AJCC/UICC 7th pathological NX Category - 1634505 AJCC/UICC 8th pathological NX Category - 1634117

        AJCC/UICC 6th pathological N0 Category - 1634212 AJCC/UICC 7th pathological N0 Category - 1633726 AJCC/UICC 8th pathological N0 Category - 1635560

        AJCC/UICC 6th pathological N1 Category - 1634562 AJCC/UICC 7th pathological N1 Category - 1634245 AJCC/UICC 8th pathological N1 Category - 1633659

        AJCC/UICC 6th pathological N2 Category - 1634541 AJCC/UICC 7th pathological N2 Category - 1633569 AJCC/UICC 8th pathological N2 Category - 1633336

        AJCC/UICC 6th pathological N2a Category - 1633273 AJCC/UICC 7th pathological N2a Category - 1635717 AJCC/UICC 8th pathological N2a Category - 1635871

        AJCC/UICC 6th pathological N2b Category - 1634773 AJCC/UICC 7th pathological N2b Category - 1633607 AJCC/UICC 8th pathological N2b Category - 1634645

        AJCC/UICC 6th pathological N2c Category - 1635113 AJCC/UICC 7th pathological N2c Category - 1634601 AJCC/UICC 8th pathological N2c Category - 1634383

        AJCC/UICC 6th pathological N3 Category - 1634504 AJCC/UICC 7th pathological N3 Category - 1633668 AJCC/UICC 8th pathological N3 Category - 1635307

        AJCC/UICC 6th pathological N3a Category - 1634271 AJCC/UICC 7th pathological N3a Category - 1634397 AJCC/UICC 8th pathological N3a Category - 1635545

        AJCC/UICC 6th pathological N3b Category - 1633500 AJCC/UICC 7th pathological N3b Category - 1634847 AJCC/UICC 8th pathological N3b Category - 1634770

        Control1..*
        TypeCodeableConcept
        Obligations
          ObligationsActor
          SHALL:handleHead and Neck
          10. PathologicalStage.pm
          Definition

          Specifies the pathological M

          ShortpM (M)
          Comments

          AJCC/UICC 6th pathological M0 Category - 1635345 AJCC/UICC 7th pathological M0 Category - 1635536 AJCC/UICC 8th pathological M0 Category - 1634606

          AJCC/UICC 6th pathological M1 Category - 1633469 AJCC/UICC 7th pathological M1 Category - 1635336 AJCC/UICC 8th pathological M1 Category - 1634891

          Control1..*
          TypeCodeableConcept
          Obligations
            ObligationsActor
            SHALL:handleHead and Neck
            12. PathologicalStage.extraNodalExtension
            Definition

            Describes the presence or absence of radiological signs of extracapsular extension, as defined in the AJCC 8th Ed check CODEs

            ShortExtra-nodal extension (rEne) (M)
            Comments

            ENE- - 36769946 ENE+ - 36770618

            Control1..*
            TypeCodeableConcept
            Obligations
              ObligationsActor
              SHALL:handleHead and Neck
              14. PathologicalStage.sentinelNode
              Definition

              Describes whether a sentinel node procedure was performed or not. Sentinel lymph node biopsy is considered a diagnostic procedure, therefore, per se, the neck is not considered to have been treated if it does not lead to a neck dissection.

              ShortSentinel node (M)
              Comments

              Sentinel lymph node biopsy - 4263386

              Control1..*
              Typeboolean
              Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
              Obligations
                ObligationsActor
                SHALL:handleHead and Neck
                16. PathologicalStage.pathologicalStaging
                Definition

                Specifies the clinical TNM

                ShortPathological staging (M)
                Comments

                AJCC/UICC 6th pathological Stage 0 - 1634741 AJCC/UICC 7th pathological Stage 0 - 1635511 AJCC/UICC 8th pathological Stage 0 - 1634787

                AJCC/UICC 6th pathological Stage 1 - 1635797 AJCC/UICC 7th pathological Stage 1 - 1635800 AJCC/UICC 8th pathological Stage 1 - 1634799

                AJCC/UICC 6th pathological Stage 2 - 1633751 AJCC/UICC 7th pathological Stage 2 - 1634619 AJCC/UICC 8th pathological Stage 2 - 1635386

                AJCC/UICC 6th pathological Stage 3 - 1633499 AJCC/UICC 7th pathological Stage 3 - 1634947 AJCC/UICC 8th pathological Stage 3 - 1634705

                AJCC/UICC 6th pathological Stage 4 - 1634208 AJCC/UICC 7th pathological Stage 4 - 1635230 AJCC/UICC 8th pathological Stage 4 - 1633697

                AJCC/UICC 6th pathological Stage 4A - 1634731 AJCC/UICC 7th pathological Stage 4A - 1635745 AJCC/UICC 8th pathological Stage 4A - 1634005

                AJCC/UICC 6th pathological Stage 4B - 1635370 AJCC/UICC 7th pathological Stage 4B - 1634472 AJCC/UICC 8th pathological Stage 4B - 1634487

                AJCC/UICC 6th pathological Stage 4C - 1635893 AJCC/UICC 7th pathological Stage 4C - 1634492 AJCC/UICC 8th pathological Stage 4C - 1634551

                Control1..*
                TypeCodeableConcept
                Obligations
                  ObligationsActor
                  SHALL:handleHead and Neck
                  18. PathologicalStage.localised
                  Definition

                  Describes if there disease is local Localised and Number of tumor modules are variables that work together

                  ShortLocalised (M)
                  Comments

                  Confined disease - 32942

                  Control1..*
                  Typeboolean
                  Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                  Obligations
                    ObligationsActor
                    SHALL:handleSarcoma
                    20. PathologicalStage.numberOfTumorNodules
                    Definition

                    Indicates the number of tumor nodules in the case the disease is localised Localised and Number of tumor modules are variables that work together

                    ShortNumber of tumor nodules (R)
                    Comments

                    Number of tumor nodules - 4228659

                    Control0..*
                    Typeinteger
                    Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                    Obligations
                      ObligationsActor
                      SHALL:handleSarcoma
                      22. PathologicalStage.locoRegional
                      Definition

                      Indicates if the disease is in a loco-regional extent

                      ShortLoco-regional (M)
                      Comments

                      Invasive Disease - 32943

                      Control1..*
                      Typeboolean
                      Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                      Obligations
                        ObligationsActor
                        SHALL:handleSarcoma
                        24. PathologicalStage.isTransitMetastasisWithClinicalConfirmation
                        Definition

                        Indicates spread of cancer cells through lymphatic vessels, where they lodge and grow in tissues located between the primary tumor and the nearest regional lymph nodes.

                        ShortIs Transit metastasis with clinical confirmation (M)
                        Comments

                        Transit Metastasis with Clinical Confirmation - 36769249

                        Control1..*
                        Typeboolean
                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                        Obligations
                          ObligationsActor
                          SHALL:handleSarcoma
                          26. PathologicalStage.isMultifocalTumor
                          Definition

                          Presence of multiple distinct tumor foci (or nodules) within the same organ or tissue, originating from the same primary tumor type. These foci may arise through independent tumorigenesis (multiple primary lesions) or local spread of the same cancer.

                          ShortIs Multifocal tumor (M)
                          Comments

                          Multifocal Tumor - 36769933

                          Control1..*
                          Typeboolean
                          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                          Obligations
                            ObligationsActor
                            SHALL:handleSarcoma
                            28. PathologicalStage.regionalNodalMetastases
                            Definition

                            Describes if regional nodal mestastases happened

                            ShortRegional nodal metastases (M)
                            Comments

                            Regional spread to lymph node - 36769269

                            Control1..*
                            Typeboolean
                            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                            Obligations
                              ObligationsActor
                              SHALL:handleHead and Neck
                              SHALL:handleSarcoma
                              30. PathologicalStage.sites
                              Definition

                              Describes if site of metastasic disease is soft tissue

                              Shortsites (R)
                              Control0..*
                              TypeBackboneElement
                              Obligations
                                ObligationsActor
                                SHALL:handleHead and Neck
                                SHALL:handleSarcoma
                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                32. PathologicalStage.sites.id
                                Definition

                                Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                ShortUnique id for inter-element referencing
                                Control0..1
                                Typestring
                                Is Modifierfalse
                                XML FormatIn the XML format, this property is represented as an attribute.
                                Summaryfalse
                                34. PathologicalStage.sites.extension
                                Definition

                                May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                ShortAdditional content defined by implementations
                                Comments

                                There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                Control0..*
                                TypeExtension
                                Is Modifierfalse
                                Summaryfalse
                                Alternate Namesextensions, user content
                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                SlicingThis element introduces a set of slices on PathologicalStage.sites.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                • value @ url
                                • 36. PathologicalStage.sites.modifierExtension
                                  Definition

                                  May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                  Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                  ShortExtensions that cannot be ignored even if unrecognized
                                  Comments

                                  There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                  Control0..*
                                  TypeExtension
                                  Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                  Summarytrue
                                  Requirements

                                  Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                  Alternate Namesextensions, user content, modifiers
                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                  ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                  38. PathologicalStage.sites.softTissue
                                  Definition

                                  Describes if site of metastasic disease is soft tissue

                                  ShortSoft tissue (R)
                                  Comments

                                  Metastasis to soft tissues - 35225724

                                  Control0..*
                                  Typeboolean
                                  Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                  Obligations
                                    ObligationsActor
                                    SHALL:handleHead and Neck
                                    SHALL:handleSarcoma
                                    40. PathologicalStage.sites.distantLymphNode
                                    Definition

                                    Describes if site of metastasic disease is dystan lymph node

                                    Shortdistant lymph node (R)
                                    Comments

                                    Distant spread to lymph node - 36769243

                                    Control0..*
                                    Typeboolean
                                    Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                    Obligations
                                      ObligationsActor
                                      SHALL:handleHead and Neck
                                      SHALL:handleSarcoma
                                      42. PathologicalStage.sites.lung
                                      Definition

                                      Describes if site of metastasic disease is lung

                                      Shortlung (R)
                                      Comments

                                      Metastasis to lung - 36770283

                                      Control0..*
                                      Typeboolean
                                      Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                      Obligations
                                        ObligationsActor
                                        SHALL:handleHead and Neck
                                        SHALL:handleSarcoma
                                        44. PathologicalStage.sites.metastasisatbone
                                        Definition

                                        Describes if site of metastasic disease is bone

                                        ShortmetastasisAtBone (R)
                                        Comments

                                        Metastasis to bone - 36769301

                                        Control0..*
                                        Typeboolean
                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                        Obligations
                                          ObligationsActor
                                          SHALL:handleHead and Neck
                                          SHALL:handleSarcoma
                                          46. PathologicalStage.sites.liver
                                          Definition

                                          Describes if site of metastasic disease is liver

                                          Shortliver (R)
                                          Comments

                                          Metastasis to liver - 36770544

                                          Control0..*
                                          Typeboolean
                                          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                          Obligations
                                            ObligationsActor
                                            SHALL:handleHead and Neck
                                            SHALL:handleSarcoma
                                            48. PathologicalStage.sites.pleura
                                            Definition

                                            Describes if site of metastasic disease is pleura

                                            Shortpleura (R)
                                            Comments

                                            Metastasis to pleura - 35226258

                                            Control0..*
                                            Typeboolean
                                            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                            Obligations
                                              ObligationsActor
                                              SHALL:handleHead and Neck
                                              SHALL:handleSarcoma
                                              50. PathologicalStage.sites.peritoneum
                                              Definition

                                              Describes if site of metastasic disease is peritoneum

                                              Shortperitoneum (R)
                                              Comments

                                              Metastasis to peritoneum - 35226253

                                              Control0..*
                                              Typeboolean
                                              Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                              Obligations
                                                ObligationsActor
                                                SHALL:handleHead and Neck
                                                SHALL:handleSarcoma
                                                52. PathologicalStage.sites.brain
                                                Definition

                                                Describes if site of metastasic disease is brain

                                                Shortbrain (R)
                                                Comments

                                                Metastasis to brain - 36768862

                                                Control0..*
                                                Typeboolean
                                                Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                Obligations
                                                  ObligationsActor
                                                  SHALL:handleHead and Neck
                                                  SHALL:handleSarcoma
                                                  54. PathologicalStage.sites.otherViscera
                                                  Definition

                                                  Describes if site of metastasic disease is other viscera Use the generic metastasis code or a metastasis subsumed in it, 36769180

                                                  Shortother viscera (R)
                                                  Comments

                                                  Metastasis - 36769180

                                                  Control0..*
                                                  Typeboolean
                                                  Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                  Obligations
                                                    ObligationsActor
                                                    SHALL:handleHead and Neck
                                                    SHALL:handleSarcoma
                                                    56. PathologicalStage.sites.unknown
                                                    Definition

                                                    Describes if site of metastasic disease is unknown

                                                    Shortunknown (R)
                                                    Comments

                                                    Unknown - 4129922

                                                    Control0..*
                                                    Typeboolean
                                                    Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                    Obligations
                                                      ObligationsActor
                                                      SHALL:handleHead and Neck
                                                      SHALL:handleSarcoma

                                                      Guidance on how to interpret the contents of this table can be foundhere

                                                      0. PathologicalStage
                                                      Definition

                                                      Pathological Stage Maturity Level: 0 Draft

                                                      ShortPathological Stage
                                                      Logical ModelInstances of this logical model are not marked to be the target of a Reference
                                                      2. PathologicalStage.diagnosisReference
                                                      Definition

                                                      Diagnosis element containing the data regarding the patient's cancer

                                                      ShortDiagnosis Reference (M)
                                                      Control1..*
                                                      Typehttp://hl7.eu/fhir/ig/idea4rc/StructureDefinition/Diagnosis
                                                      Obligations
                                                        ObligationsActor
                                                        SHALL:handleHead and Neck
                                                        SHALL:handleSarcoma
                                                        4. PathologicalStage.stagingProceduresDoneBy
                                                        Definition

                                                        Describes the ID of the institution where staging procedure for primary tumour was performed

                                                        ShortStaging procedures done by (M)
                                                        Control1..*
                                                        Typestring
                                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                        Obligations
                                                          ObligationsActor
                                                          SHALL:handleHead and Neck
                                                          6. PathologicalStage.pt
                                                          Definition

                                                          Specifies the pathological T

                                                          ShortpT (M)
                                                          Comments

                                                          AJCC/UICC 6th pathological TX Category - 1634270 AJCC/UICC 7th pathological TX Category - 1635402 AJCC/UICC 8th pathological TX Category - 1634986

                                                          AJCC/UICC 6th Tis Category - 1635660 AJCC/UICC 7th Tis Category - 1633798 AJCC/UICC 8th Tis Category - 1634720

                                                          AJCC/UICC 6th pathological T0 Category - 1633279 AJCC/UICC 7th pathological T0 Category - 1634675 AJCC/UICC 8th pathological T0 Category - 1634635

                                                          AJCC/UICC 6th pathological T1 Category - 1633445 AJCC/UICC 7th pathological T1 Category - 1635422 AJCC/UICC 8th pathological T1 Category - 1635070

                                                          AJCC/UICC 6th pathological T2 Category - 1634792 AJCC/UICC 7th pathological T2 Category - 1634491 AJCC/UICC 8th pathological T2 Category - 1633307

                                                          AJCC/UICC 6th pathological T3 Category - 1635670 AJCC/UICC 7th pathological T3 Category - 1634658 AJCC/UICC 8th pathological T3 Category - 1634386

                                                          AJCC/UICC 6th pathological T4 Category - 1635311 AJCC/UICC 7th pathological T4 Category - 1635341 AJCC/UICC 8th pathological T4 Category - 1635396

                                                          AJCC/UICC 6th pathological T4a Category - 1634101 AJCC/UICC 7th pathological T4a Category - 1633723 AJCC/UICC 8th pathological T4a Category - 1634894

                                                          AJCC/UICC 6th pathological T4b Category - 1633900 AJCC/UICC 7th pathological T4b Category - 1633699 AJCC/UICC 8th pathological T4b Category - 1633658

                                                          Control1..*
                                                          TypeCodeableConcept
                                                          Obligations
                                                            ObligationsActor
                                                            SHALL:handleHead and Neck
                                                            8. PathologicalStage.pn
                                                            Definition

                                                            Specifies the pathological N

                                                            ShortpN (M)
                                                            Comments

                                                            AJCC/UICC 6th pathological NX Category - 1635823 AJCC/UICC 7th pathological NX Category - 1634505 AJCC/UICC 8th pathological NX Category - 1634117

                                                            AJCC/UICC 6th pathological N0 Category - 1634212 AJCC/UICC 7th pathological N0 Category - 1633726 AJCC/UICC 8th pathological N0 Category - 1635560

                                                            AJCC/UICC 6th pathological N1 Category - 1634562 AJCC/UICC 7th pathological N1 Category - 1634245 AJCC/UICC 8th pathological N1 Category - 1633659

                                                            AJCC/UICC 6th pathological N2 Category - 1634541 AJCC/UICC 7th pathological N2 Category - 1633569 AJCC/UICC 8th pathological N2 Category - 1633336

                                                            AJCC/UICC 6th pathological N2a Category - 1633273 AJCC/UICC 7th pathological N2a Category - 1635717 AJCC/UICC 8th pathological N2a Category - 1635871

                                                            AJCC/UICC 6th pathological N2b Category - 1634773 AJCC/UICC 7th pathological N2b Category - 1633607 AJCC/UICC 8th pathological N2b Category - 1634645

                                                            AJCC/UICC 6th pathological N2c Category - 1635113 AJCC/UICC 7th pathological N2c Category - 1634601 AJCC/UICC 8th pathological N2c Category - 1634383

                                                            AJCC/UICC 6th pathological N3 Category - 1634504 AJCC/UICC 7th pathological N3 Category - 1633668 AJCC/UICC 8th pathological N3 Category - 1635307

                                                            AJCC/UICC 6th pathological N3a Category - 1634271 AJCC/UICC 7th pathological N3a Category - 1634397 AJCC/UICC 8th pathological N3a Category - 1635545

                                                            AJCC/UICC 6th pathological N3b Category - 1633500 AJCC/UICC 7th pathological N3b Category - 1634847 AJCC/UICC 8th pathological N3b Category - 1634770

                                                            Control1..*
                                                            TypeCodeableConcept
                                                            Obligations
                                                              ObligationsActor
                                                              SHALL:handleHead and Neck
                                                              10. PathologicalStage.pm
                                                              Definition

                                                              Specifies the pathological M

                                                              ShortpM (M)
                                                              Comments

                                                              AJCC/UICC 6th pathological M0 Category - 1635345 AJCC/UICC 7th pathological M0 Category - 1635536 AJCC/UICC 8th pathological M0 Category - 1634606

                                                              AJCC/UICC 6th pathological M1 Category - 1633469 AJCC/UICC 7th pathological M1 Category - 1635336 AJCC/UICC 8th pathological M1 Category - 1634891

                                                              Control1..*
                                                              TypeCodeableConcept
                                                              Obligations
                                                                ObligationsActor
                                                                SHALL:handleHead and Neck
                                                                12. PathologicalStage.extraNodalExtension
                                                                Definition

                                                                Describes the presence or absence of radiological signs of extracapsular extension, as defined in the AJCC 8th Ed check CODEs

                                                                ShortExtra-nodal extension (rEne) (M)
                                                                Comments

                                                                ENE- - 36769946 ENE+ - 36770618

                                                                Control1..*
                                                                TypeCodeableConcept
                                                                Obligations
                                                                  ObligationsActor
                                                                  SHALL:handleHead and Neck
                                                                  14. PathologicalStage.sentinelNode
                                                                  Definition

                                                                  Describes whether a sentinel node procedure was performed or not. Sentinel lymph node biopsy is considered a diagnostic procedure, therefore, per se, the neck is not considered to have been treated if it does not lead to a neck dissection.

                                                                  ShortSentinel node (M)
                                                                  Comments

                                                                  Sentinel lymph node biopsy - 4263386

                                                                  Control1..*
                                                                  Typeboolean
                                                                  Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                  Obligations
                                                                    ObligationsActor
                                                                    SHALL:handleHead and Neck
                                                                    16. PathologicalStage.pathologicalStaging
                                                                    Definition

                                                                    Specifies the clinical TNM

                                                                    ShortPathological staging (M)
                                                                    Comments

                                                                    AJCC/UICC 6th pathological Stage 0 - 1634741 AJCC/UICC 7th pathological Stage 0 - 1635511 AJCC/UICC 8th pathological Stage 0 - 1634787

                                                                    AJCC/UICC 6th pathological Stage 1 - 1635797 AJCC/UICC 7th pathological Stage 1 - 1635800 AJCC/UICC 8th pathological Stage 1 - 1634799

                                                                    AJCC/UICC 6th pathological Stage 2 - 1633751 AJCC/UICC 7th pathological Stage 2 - 1634619 AJCC/UICC 8th pathological Stage 2 - 1635386

                                                                    AJCC/UICC 6th pathological Stage 3 - 1633499 AJCC/UICC 7th pathological Stage 3 - 1634947 AJCC/UICC 8th pathological Stage 3 - 1634705

                                                                    AJCC/UICC 6th pathological Stage 4 - 1634208 AJCC/UICC 7th pathological Stage 4 - 1635230 AJCC/UICC 8th pathological Stage 4 - 1633697

                                                                    AJCC/UICC 6th pathological Stage 4A - 1634731 AJCC/UICC 7th pathological Stage 4A - 1635745 AJCC/UICC 8th pathological Stage 4A - 1634005

                                                                    AJCC/UICC 6th pathological Stage 4B - 1635370 AJCC/UICC 7th pathological Stage 4B - 1634472 AJCC/UICC 8th pathological Stage 4B - 1634487

                                                                    AJCC/UICC 6th pathological Stage 4C - 1635893 AJCC/UICC 7th pathological Stage 4C - 1634492 AJCC/UICC 8th pathological Stage 4C - 1634551

                                                                    Control1..*
                                                                    TypeCodeableConcept
                                                                    Obligations
                                                                      ObligationsActor
                                                                      SHALL:handleHead and Neck
                                                                      18. PathologicalStage.localised
                                                                      Definition

                                                                      Describes if there disease is local Localised and Number of tumor modules are variables that work together

                                                                      ShortLocalised (M)
                                                                      Comments

                                                                      Confined disease - 32942

                                                                      Control1..*
                                                                      Typeboolean
                                                                      Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                      Obligations
                                                                        ObligationsActor
                                                                        SHALL:handleSarcoma
                                                                        20. PathologicalStage.numberOfTumorNodules
                                                                        Definition

                                                                        Indicates the number of tumor nodules in the case the disease is localised Localised and Number of tumor modules are variables that work together

                                                                        ShortNumber of tumor nodules (R)
                                                                        Comments

                                                                        Number of tumor nodules - 4228659

                                                                        Control0..*
                                                                        Typeinteger
                                                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                        Obligations
                                                                          ObligationsActor
                                                                          SHALL:handleSarcoma
                                                                          22. PathologicalStage.locoRegional
                                                                          Definition

                                                                          Indicates if the disease is in a loco-regional extent

                                                                          ShortLoco-regional (M)
                                                                          Comments

                                                                          Invasive Disease - 32943

                                                                          Control1..*
                                                                          Typeboolean
                                                                          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                          Obligations
                                                                            ObligationsActor
                                                                            SHALL:handleSarcoma
                                                                            24. PathologicalStage.isTransitMetastasisWithClinicalConfirmation
                                                                            Definition

                                                                            Indicates spread of cancer cells through lymphatic vessels, where they lodge and grow in tissues located between the primary tumor and the nearest regional lymph nodes.

                                                                            ShortIs Transit metastasis with clinical confirmation (M)
                                                                            Comments

                                                                            Transit Metastasis with Clinical Confirmation - 36769249

                                                                            Control1..*
                                                                            Typeboolean
                                                                            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                            Obligations
                                                                              ObligationsActor
                                                                              SHALL:handleSarcoma
                                                                              26. PathologicalStage.isMultifocalTumor
                                                                              Definition

                                                                              Presence of multiple distinct tumor foci (or nodules) within the same organ or tissue, originating from the same primary tumor type. These foci may arise through independent tumorigenesis (multiple primary lesions) or local spread of the same cancer.

                                                                              ShortIs Multifocal tumor (M)
                                                                              Comments

                                                                              Multifocal Tumor - 36769933

                                                                              Control1..*
                                                                              Typeboolean
                                                                              Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                              Obligations
                                                                                ObligationsActor
                                                                                SHALL:handleSarcoma
                                                                                28. PathologicalStage.regionalNodalMetastases
                                                                                Definition

                                                                                Describes if regional nodal mestastases happened

                                                                                ShortRegional nodal metastases (M)
                                                                                Comments

                                                                                Regional spread to lymph node - 36769269

                                                                                Control1..*
                                                                                Typeboolean
                                                                                Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                Obligations
                                                                                  ObligationsActor
                                                                                  SHALL:handleHead and Neck
                                                                                  SHALL:handleSarcoma
                                                                                  30. PathologicalStage.sites
                                                                                  Definition

                                                                                  Describes if site of metastasic disease is soft tissue

                                                                                  Shortsites (R)
                                                                                  Control0..*
                                                                                  TypeBackboneElement
                                                                                  Obligations
                                                                                    ObligationsActor
                                                                                    SHALL:handleHead and Neck
                                                                                    SHALL:handleSarcoma
                                                                                    32. PathologicalStage.sites.softTissue
                                                                                    Definition

                                                                                    Describes if site of metastasic disease is soft tissue

                                                                                    ShortSoft tissue (R)
                                                                                    Comments

                                                                                    Metastasis to soft tissues - 35225724

                                                                                    Control0..*
                                                                                    Typeboolean
                                                                                    Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                    Obligations
                                                                                      ObligationsActor
                                                                                      SHALL:handleHead and Neck
                                                                                      SHALL:handleSarcoma
                                                                                      34. PathologicalStage.sites.distantLymphNode
                                                                                      Definition

                                                                                      Describes if site of metastasic disease is dystan lymph node

                                                                                      Shortdistant lymph node (R)
                                                                                      Comments

                                                                                      Distant spread to lymph node - 36769243

                                                                                      Control0..*
                                                                                      Typeboolean
                                                                                      Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                      Obligations
                                                                                        ObligationsActor
                                                                                        SHALL:handleHead and Neck
                                                                                        SHALL:handleSarcoma
                                                                                        36. PathologicalStage.sites.lung
                                                                                        Definition

                                                                                        Describes if site of metastasic disease is lung

                                                                                        Shortlung (R)
                                                                                        Comments

                                                                                        Metastasis to lung - 36770283

                                                                                        Control0..*
                                                                                        Typeboolean
                                                                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                        Obligations
                                                                                          ObligationsActor
                                                                                          SHALL:handleHead and Neck
                                                                                          SHALL:handleSarcoma
                                                                                          38. PathologicalStage.sites.metastasisatbone
                                                                                          Definition

                                                                                          Describes if site of metastasic disease is bone

                                                                                          ShortmetastasisAtBone (R)
                                                                                          Comments

                                                                                          Metastasis to bone - 36769301

                                                                                          Control0..*
                                                                                          Typeboolean
                                                                                          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                          Obligations
                                                                                            ObligationsActor
                                                                                            SHALL:handleHead and Neck
                                                                                            SHALL:handleSarcoma
                                                                                            40. PathologicalStage.sites.liver
                                                                                            Definition

                                                                                            Describes if site of metastasic disease is liver

                                                                                            Shortliver (R)
                                                                                            Comments

                                                                                            Metastasis to liver - 36770544

                                                                                            Control0..*
                                                                                            Typeboolean
                                                                                            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                            Obligations
                                                                                              ObligationsActor
                                                                                              SHALL:handleHead and Neck
                                                                                              SHALL:handleSarcoma
                                                                                              42. PathologicalStage.sites.pleura
                                                                                              Definition

                                                                                              Describes if site of metastasic disease is pleura

                                                                                              Shortpleura (R)
                                                                                              Comments

                                                                                              Metastasis to pleura - 35226258

                                                                                              Control0..*
                                                                                              Typeboolean
                                                                                              Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                              Obligations
                                                                                                ObligationsActor
                                                                                                SHALL:handleHead and Neck
                                                                                                SHALL:handleSarcoma
                                                                                                44. PathologicalStage.sites.peritoneum
                                                                                                Definition

                                                                                                Describes if site of metastasic disease is peritoneum

                                                                                                Shortperitoneum (R)
                                                                                                Comments

                                                                                                Metastasis to peritoneum - 35226253

                                                                                                Control0..*
                                                                                                Typeboolean
                                                                                                Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                Obligations
                                                                                                  ObligationsActor
                                                                                                  SHALL:handleHead and Neck
                                                                                                  SHALL:handleSarcoma
                                                                                                  46. PathologicalStage.sites.brain
                                                                                                  Definition

                                                                                                  Describes if site of metastasic disease is brain

                                                                                                  Shortbrain (R)
                                                                                                  Comments

                                                                                                  Metastasis to brain - 36768862

                                                                                                  Control0..*
                                                                                                  Typeboolean
                                                                                                  Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                  Obligations
                                                                                                    ObligationsActor
                                                                                                    SHALL:handleHead and Neck
                                                                                                    SHALL:handleSarcoma
                                                                                                    48. PathologicalStage.sites.otherViscera
                                                                                                    Definition

                                                                                                    Describes if site of metastasic disease is other viscera Use the generic metastasis code or a metastasis subsumed in it, 36769180

                                                                                                    Shortother viscera (R)
                                                                                                    Comments

                                                                                                    Metastasis - 36769180

                                                                                                    Control0..*
                                                                                                    Typeboolean
                                                                                                    Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                    Obligations
                                                                                                      ObligationsActor
                                                                                                      SHALL:handleHead and Neck
                                                                                                      SHALL:handleSarcoma
                                                                                                      50. PathologicalStage.sites.unknown
                                                                                                      Definition

                                                                                                      Describes if site of metastasic disease is unknown

                                                                                                      Shortunknown (R)
                                                                                                      Comments

                                                                                                      Unknown - 4129922

                                                                                                      Control0..*
                                                                                                      Typeboolean
                                                                                                      Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                      Obligations
                                                                                                        ObligationsActor
                                                                                                        SHALL:handleHead and Neck
                                                                                                        SHALL:handleSarcoma

                                                                                                        Guidance on how to interpret the contents of this table can be foundhere

                                                                                                        0. PathologicalStage
                                                                                                        Definition

                                                                                                        Pathological Stage Maturity Level: 0 Draft

                                                                                                        ShortPathological Stage
                                                                                                        Control0..*
                                                                                                        Is Modifierfalse
                                                                                                        Logical ModelInstances of this logical model are not marked to be the target of a Reference
                                                                                                        2. PathologicalStage.diagnosisReference
                                                                                                        Definition

                                                                                                        Diagnosis element containing the data regarding the patient's cancer

                                                                                                        ShortDiagnosis Reference (M)
                                                                                                        Control1..*
                                                                                                        Typehttp://hl7.eu/fhir/ig/idea4rc/StructureDefinition/Diagnosis
                                                                                                        Obligations
                                                                                                          ObligationsActor
                                                                                                          SHALL:handleHead and Neck
                                                                                                          SHALL:handleSarcoma
                                                                                                          4. PathologicalStage.stagingProceduresDoneBy
                                                                                                          Definition

                                                                                                          Describes the ID of the institution where staging procedure for primary tumour was performed

                                                                                                          ShortStaging procedures done by (M)
                                                                                                          Control1..*
                                                                                                          Typestring
                                                                                                          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                          Obligations
                                                                                                            ObligationsActor
                                                                                                            SHALL:handleHead and Neck
                                                                                                            6. PathologicalStage.pt
                                                                                                            Definition

                                                                                                            Specifies the pathological T

                                                                                                            ShortpT (M)
                                                                                                            Comments

                                                                                                            AJCC/UICC 6th pathological TX Category - 1634270 AJCC/UICC 7th pathological TX Category - 1635402 AJCC/UICC 8th pathological TX Category - 1634986

                                                                                                            AJCC/UICC 6th Tis Category - 1635660 AJCC/UICC 7th Tis Category - 1633798 AJCC/UICC 8th Tis Category - 1634720

                                                                                                            AJCC/UICC 6th pathological T0 Category - 1633279 AJCC/UICC 7th pathological T0 Category - 1634675 AJCC/UICC 8th pathological T0 Category - 1634635

                                                                                                            AJCC/UICC 6th pathological T1 Category - 1633445 AJCC/UICC 7th pathological T1 Category - 1635422 AJCC/UICC 8th pathological T1 Category - 1635070

                                                                                                            AJCC/UICC 6th pathological T2 Category - 1634792 AJCC/UICC 7th pathological T2 Category - 1634491 AJCC/UICC 8th pathological T2 Category - 1633307

                                                                                                            AJCC/UICC 6th pathological T3 Category - 1635670 AJCC/UICC 7th pathological T3 Category - 1634658 AJCC/UICC 8th pathological T3 Category - 1634386

                                                                                                            AJCC/UICC 6th pathological T4 Category - 1635311 AJCC/UICC 7th pathological T4 Category - 1635341 AJCC/UICC 8th pathological T4 Category - 1635396

                                                                                                            AJCC/UICC 6th pathological T4a Category - 1634101 AJCC/UICC 7th pathological T4a Category - 1633723 AJCC/UICC 8th pathological T4a Category - 1634894

                                                                                                            AJCC/UICC 6th pathological T4b Category - 1633900 AJCC/UICC 7th pathological T4b Category - 1633699 AJCC/UICC 8th pathological T4b Category - 1633658

                                                                                                            Control1..*
                                                                                                            TypeCodeableConcept
                                                                                                            Obligations
                                                                                                              ObligationsActor
                                                                                                              SHALL:handleHead and Neck
                                                                                                              8. PathologicalStage.pn
                                                                                                              Definition

                                                                                                              Specifies the pathological N

                                                                                                              ShortpN (M)
                                                                                                              Comments

                                                                                                              AJCC/UICC 6th pathological NX Category - 1635823 AJCC/UICC 7th pathological NX Category - 1634505 AJCC/UICC 8th pathological NX Category - 1634117

                                                                                                              AJCC/UICC 6th pathological N0 Category - 1634212 AJCC/UICC 7th pathological N0 Category - 1633726 AJCC/UICC 8th pathological N0 Category - 1635560

                                                                                                              AJCC/UICC 6th pathological N1 Category - 1634562 AJCC/UICC 7th pathological N1 Category - 1634245 AJCC/UICC 8th pathological N1 Category - 1633659

                                                                                                              AJCC/UICC 6th pathological N2 Category - 1634541 AJCC/UICC 7th pathological N2 Category - 1633569 AJCC/UICC 8th pathological N2 Category - 1633336

                                                                                                              AJCC/UICC 6th pathological N2a Category - 1633273 AJCC/UICC 7th pathological N2a Category - 1635717 AJCC/UICC 8th pathological N2a Category - 1635871

                                                                                                              AJCC/UICC 6th pathological N2b Category - 1634773 AJCC/UICC 7th pathological N2b Category - 1633607 AJCC/UICC 8th pathological N2b Category - 1634645

                                                                                                              AJCC/UICC 6th pathological N2c Category - 1635113 AJCC/UICC 7th pathological N2c Category - 1634601 AJCC/UICC 8th pathological N2c Category - 1634383

                                                                                                              AJCC/UICC 6th pathological N3 Category - 1634504 AJCC/UICC 7th pathological N3 Category - 1633668 AJCC/UICC 8th pathological N3 Category - 1635307

                                                                                                              AJCC/UICC 6th pathological N3a Category - 1634271 AJCC/UICC 7th pathological N3a Category - 1634397 AJCC/UICC 8th pathological N3a Category - 1635545

                                                                                                              AJCC/UICC 6th pathological N3b Category - 1633500 AJCC/UICC 7th pathological N3b Category - 1634847 AJCC/UICC 8th pathological N3b Category - 1634770

                                                                                                              Control1..*
                                                                                                              TypeCodeableConcept
                                                                                                              Obligations
                                                                                                                ObligationsActor
                                                                                                                SHALL:handleHead and Neck
                                                                                                                10. PathologicalStage.pm
                                                                                                                Definition

                                                                                                                Specifies the pathological M

                                                                                                                ShortpM (M)
                                                                                                                Comments

                                                                                                                AJCC/UICC 6th pathological M0 Category - 1635345 AJCC/UICC 7th pathological M0 Category - 1635536 AJCC/UICC 8th pathological M0 Category - 1634606

                                                                                                                AJCC/UICC 6th pathological M1 Category - 1633469 AJCC/UICC 7th pathological M1 Category - 1635336 AJCC/UICC 8th pathological M1 Category - 1634891

                                                                                                                Control1..*
                                                                                                                TypeCodeableConcept
                                                                                                                Obligations
                                                                                                                  ObligationsActor
                                                                                                                  SHALL:handleHead and Neck
                                                                                                                  12. PathologicalStage.extraNodalExtension
                                                                                                                  Definition

                                                                                                                  Describes the presence or absence of radiological signs of extracapsular extension, as defined in the AJCC 8th Ed check CODEs

                                                                                                                  ShortExtra-nodal extension (rEne) (M)
                                                                                                                  Comments

                                                                                                                  ENE- - 36769946 ENE+ - 36770618

                                                                                                                  Control1..*
                                                                                                                  TypeCodeableConcept
                                                                                                                  Obligations
                                                                                                                    ObligationsActor
                                                                                                                    SHALL:handleHead and Neck
                                                                                                                    14. PathologicalStage.sentinelNode
                                                                                                                    Definition

                                                                                                                    Describes whether a sentinel node procedure was performed or not. Sentinel lymph node biopsy is considered a diagnostic procedure, therefore, per se, the neck is not considered to have been treated if it does not lead to a neck dissection.

                                                                                                                    ShortSentinel node (M)
                                                                                                                    Comments

                                                                                                                    Sentinel lymph node biopsy - 4263386

                                                                                                                    Control1..*
                                                                                                                    Typeboolean
                                                                                                                    Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                                    Obligations
                                                                                                                      ObligationsActor
                                                                                                                      SHALL:handleHead and Neck
                                                                                                                      16. PathologicalStage.pathologicalStaging
                                                                                                                      Definition

                                                                                                                      Specifies the clinical TNM

                                                                                                                      ShortPathological staging (M)
                                                                                                                      Comments

                                                                                                                      AJCC/UICC 6th pathological Stage 0 - 1634741 AJCC/UICC 7th pathological Stage 0 - 1635511 AJCC/UICC 8th pathological Stage 0 - 1634787

                                                                                                                      AJCC/UICC 6th pathological Stage 1 - 1635797 AJCC/UICC 7th pathological Stage 1 - 1635800 AJCC/UICC 8th pathological Stage 1 - 1634799

                                                                                                                      AJCC/UICC 6th pathological Stage 2 - 1633751 AJCC/UICC 7th pathological Stage 2 - 1634619 AJCC/UICC 8th pathological Stage 2 - 1635386

                                                                                                                      AJCC/UICC 6th pathological Stage 3 - 1633499 AJCC/UICC 7th pathological Stage 3 - 1634947 AJCC/UICC 8th pathological Stage 3 - 1634705

                                                                                                                      AJCC/UICC 6th pathological Stage 4 - 1634208 AJCC/UICC 7th pathological Stage 4 - 1635230 AJCC/UICC 8th pathological Stage 4 - 1633697

                                                                                                                      AJCC/UICC 6th pathological Stage 4A - 1634731 AJCC/UICC 7th pathological Stage 4A - 1635745 AJCC/UICC 8th pathological Stage 4A - 1634005

                                                                                                                      AJCC/UICC 6th pathological Stage 4B - 1635370 AJCC/UICC 7th pathological Stage 4B - 1634472 AJCC/UICC 8th pathological Stage 4B - 1634487

                                                                                                                      AJCC/UICC 6th pathological Stage 4C - 1635893 AJCC/UICC 7th pathological Stage 4C - 1634492 AJCC/UICC 8th pathological Stage 4C - 1634551

                                                                                                                      Control1..*
                                                                                                                      TypeCodeableConcept
                                                                                                                      Obligations
                                                                                                                        ObligationsActor
                                                                                                                        SHALL:handleHead and Neck
                                                                                                                        18. PathologicalStage.localised
                                                                                                                        Definition

                                                                                                                        Describes if there disease is local Localised and Number of tumor modules are variables that work together

                                                                                                                        ShortLocalised (M)
                                                                                                                        Comments

                                                                                                                        Confined disease - 32942

                                                                                                                        Control1..*
                                                                                                                        Typeboolean
                                                                                                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                                        Obligations
                                                                                                                          ObligationsActor
                                                                                                                          SHALL:handleSarcoma
                                                                                                                          20. PathologicalStage.numberOfTumorNodules
                                                                                                                          Definition

                                                                                                                          Indicates the number of tumor nodules in the case the disease is localised Localised and Number of tumor modules are variables that work together

                                                                                                                          ShortNumber of tumor nodules (R)
                                                                                                                          Comments

                                                                                                                          Number of tumor nodules - 4228659

                                                                                                                          Control0..*
                                                                                                                          Typeinteger
                                                                                                                          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                                          Obligations
                                                                                                                            ObligationsActor
                                                                                                                            SHALL:handleSarcoma
                                                                                                                            22. PathologicalStage.locoRegional
                                                                                                                            Definition

                                                                                                                            Indicates if the disease is in a loco-regional extent

                                                                                                                            ShortLoco-regional (M)
                                                                                                                            Comments

                                                                                                                            Invasive Disease - 32943

                                                                                                                            Control1..*
                                                                                                                            Typeboolean
                                                                                                                            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                                            Obligations
                                                                                                                              ObligationsActor
                                                                                                                              SHALL:handleSarcoma
                                                                                                                              24. PathologicalStage.isTransitMetastasisWithClinicalConfirmation
                                                                                                                              Definition

                                                                                                                              Indicates spread of cancer cells through lymphatic vessels, where they lodge and grow in tissues located between the primary tumor and the nearest regional lymph nodes.

                                                                                                                              ShortIs Transit metastasis with clinical confirmation (M)
                                                                                                                              Comments

                                                                                                                              Transit Metastasis with Clinical Confirmation - 36769249

                                                                                                                              Control1..*
                                                                                                                              Typeboolean
                                                                                                                              Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                                              Obligations
                                                                                                                                ObligationsActor
                                                                                                                                SHALL:handleSarcoma
                                                                                                                                26. PathologicalStage.isMultifocalTumor
                                                                                                                                Definition

                                                                                                                                Presence of multiple distinct tumor foci (or nodules) within the same organ or tissue, originating from the same primary tumor type. These foci may arise through independent tumorigenesis (multiple primary lesions) or local spread of the same cancer.

                                                                                                                                ShortIs Multifocal tumor (M)
                                                                                                                                Comments

                                                                                                                                Multifocal Tumor - 36769933

                                                                                                                                Control1..*
                                                                                                                                Typeboolean
                                                                                                                                Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                                                Obligations
                                                                                                                                  ObligationsActor
                                                                                                                                  SHALL:handleSarcoma
                                                                                                                                  28. PathologicalStage.regionalNodalMetastases
                                                                                                                                  Definition

                                                                                                                                  Describes if regional nodal mestastases happened

                                                                                                                                  ShortRegional nodal metastases (M)
                                                                                                                                  Comments

                                                                                                                                  Regional spread to lymph node - 36769269

                                                                                                                                  Control1..*
                                                                                                                                  Typeboolean
                                                                                                                                  Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                                                  Obligations
                                                                                                                                    ObligationsActor
                                                                                                                                    SHALL:handleHead and Neck
                                                                                                                                    SHALL:handleSarcoma
                                                                                                                                    30. PathologicalStage.sites
                                                                                                                                    Definition

                                                                                                                                    Describes if site of metastasic disease is soft tissue

                                                                                                                                    Shortsites (R)
                                                                                                                                    Control0..*
                                                                                                                                    TypeBackboneElement
                                                                                                                                    Obligations
                                                                                                                                      ObligationsActor
                                                                                                                                      SHALL:handleHead and Neck
                                                                                                                                      SHALL:handleSarcoma
                                                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                                      32. PathologicalStage.sites.id
                                                                                                                                      Definition

                                                                                                                                      Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                                                                                      ShortUnique id for inter-element referencing
                                                                                                                                      Control0..1
                                                                                                                                      Typestring
                                                                                                                                      Is Modifierfalse
                                                                                                                                      XML FormatIn the XML format, this property is represented as an attribute.
                                                                                                                                      Summaryfalse
                                                                                                                                      34. PathologicalStage.sites.extension
                                                                                                                                      Definition

                                                                                                                                      May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                                                                                                                      ShortAdditional content defined by implementations
                                                                                                                                      Comments

                                                                                                                                      There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                                                                      Control0..*
                                                                                                                                      TypeExtension
                                                                                                                                      Is Modifierfalse
                                                                                                                                      Summaryfalse
                                                                                                                                      Alternate Namesextensions, user content
                                                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                                      ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                                                      SlicingThis element introduces a set of slices on PathologicalStage.sites.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                                                                                                      • value @ url
                                                                                                                                      • 36. PathologicalStage.sites.modifierExtension
                                                                                                                                        Definition

                                                                                                                                        May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                                                                                                                        Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                                                                                                                        ShortExtensions that cannot be ignored even if unrecognized
                                                                                                                                        Comments

                                                                                                                                        There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                                                                        Control0..*
                                                                                                                                        TypeExtension
                                                                                                                                        Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                                                                                                                        Summarytrue
                                                                                                                                        Requirements

                                                                                                                                        Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                                                                                                                        Alternate Namesextensions, user content, modifiers
                                                                                                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                                                        38. PathologicalStage.sites.softTissue
                                                                                                                                        Definition

                                                                                                                                        Describes if site of metastasic disease is soft tissue

                                                                                                                                        ShortSoft tissue (R)
                                                                                                                                        Comments

                                                                                                                                        Metastasis to soft tissues - 35225724

                                                                                                                                        Control0..*
                                                                                                                                        Typeboolean
                                                                                                                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                                                        Obligations
                                                                                                                                          ObligationsActor
                                                                                                                                          SHALL:handleHead and Neck
                                                                                                                                          SHALL:handleSarcoma
                                                                                                                                          40. PathologicalStage.sites.distantLymphNode
                                                                                                                                          Definition

                                                                                                                                          Describes if site of metastasic disease is dystan lymph node

                                                                                                                                          Shortdistant lymph node (R)
                                                                                                                                          Comments

                                                                                                                                          Distant spread to lymph node - 36769243

                                                                                                                                          Control0..*
                                                                                                                                          Typeboolean
                                                                                                                                          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                                                          Obligations
                                                                                                                                            ObligationsActor
                                                                                                                                            SHALL:handleHead and Neck
                                                                                                                                            SHALL:handleSarcoma
                                                                                                                                            42. PathologicalStage.sites.lung
                                                                                                                                            Definition

                                                                                                                                            Describes if site of metastasic disease is lung

                                                                                                                                            Shortlung (R)
                                                                                                                                            Comments

                                                                                                                                            Metastasis to lung - 36770283

                                                                                                                                            Control0..*
                                                                                                                                            Typeboolean
                                                                                                                                            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                                                            Obligations
                                                                                                                                              ObligationsActor
                                                                                                                                              SHALL:handleHead and Neck
                                                                                                                                              SHALL:handleSarcoma
                                                                                                                                              44. PathologicalStage.sites.metastasisatbone
                                                                                                                                              Definition

                                                                                                                                              Describes if site of metastasic disease is bone

                                                                                                                                              ShortmetastasisAtBone (R)
                                                                                                                                              Comments

                                                                                                                                              Metastasis to bone - 36769301

                                                                                                                                              Control0..*
                                                                                                                                              Typeboolean
                                                                                                                                              Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                                                              Obligations
                                                                                                                                                ObligationsActor
                                                                                                                                                SHALL:handleHead and Neck
                                                                                                                                                SHALL:handleSarcoma
                                                                                                                                                46. PathologicalStage.sites.liver
                                                                                                                                                Definition

                                                                                                                                                Describes if site of metastasic disease is liver

                                                                                                                                                Shortliver (R)
                                                                                                                                                Comments

                                                                                                                                                Metastasis to liver - 36770544

                                                                                                                                                Control0..*
                                                                                                                                                Typeboolean
                                                                                                                                                Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                                                                Obligations
                                                                                                                                                  ObligationsActor
                                                                                                                                                  SHALL:handleHead and Neck
                                                                                                                                                  SHALL:handleSarcoma
                                                                                                                                                  48. PathologicalStage.sites.pleura
                                                                                                                                                  Definition

                                                                                                                                                  Describes if site of metastasic disease is pleura

                                                                                                                                                  Shortpleura (R)
                                                                                                                                                  Comments

                                                                                                                                                  Metastasis to pleura - 35226258

                                                                                                                                                  Control0..*
                                                                                                                                                  Typeboolean
                                                                                                                                                  Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                                                                  Obligations
                                                                                                                                                    ObligationsActor
                                                                                                                                                    SHALL:handleHead and Neck
                                                                                                                                                    SHALL:handleSarcoma
                                                                                                                                                    50. PathologicalStage.sites.peritoneum
                                                                                                                                                    Definition

                                                                                                                                                    Describes if site of metastasic disease is peritoneum

                                                                                                                                                    Shortperitoneum (R)
                                                                                                                                                    Comments

                                                                                                                                                    Metastasis to peritoneum - 35226253

                                                                                                                                                    Control0..*
                                                                                                                                                    Typeboolean
                                                                                                                                                    Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                                                                    Obligations
                                                                                                                                                      ObligationsActor
                                                                                                                                                      SHALL:handleHead and Neck
                                                                                                                                                      SHALL:handleSarcoma
                                                                                                                                                      52. PathologicalStage.sites.brain
                                                                                                                                                      Definition

                                                                                                                                                      Describes if site of metastasic disease is brain

                                                                                                                                                      Shortbrain (R)
                                                                                                                                                      Comments

                                                                                                                                                      Metastasis to brain - 36768862

                                                                                                                                                      Control0..*
                                                                                                                                                      Typeboolean
                                                                                                                                                      Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                                                                      Obligations
                                                                                                                                                        ObligationsActor
                                                                                                                                                        SHALL:handleHead and Neck
                                                                                                                                                        SHALL:handleSarcoma
                                                                                                                                                        54. PathologicalStage.sites.otherViscera
                                                                                                                                                        Definition

                                                                                                                                                        Describes if site of metastasic disease is other viscera Use the generic metastasis code or a metastasis subsumed in it, 36769180

                                                                                                                                                        Shortother viscera (R)
                                                                                                                                                        Comments

                                                                                                                                                        Metastasis - 36769180

                                                                                                                                                        Control0..*
                                                                                                                                                        Typeboolean
                                                                                                                                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                                                                        Obligations
                                                                                                                                                          ObligationsActor
                                                                                                                                                          SHALL:handleHead and Neck
                                                                                                                                                          SHALL:handleSarcoma
                                                                                                                                                          56. PathologicalStage.sites.unknown
                                                                                                                                                          Definition

                                                                                                                                                          Describes if site of metastasic disease is unknown

                                                                                                                                                          Shortunknown (R)
                                                                                                                                                          Comments

                                                                                                                                                          Unknown - 4129922

                                                                                                                                                          Control0..*
                                                                                                                                                          Typeboolean
                                                                                                                                                          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                                                                          Obligations
                                                                                                                                                            ObligationsActor
                                                                                                                                                            SHALL:handleHead and Neck
                                                                                                                                                            SHALL:handleSarcoma