IDEA4RC FHIR Implementation Guide
0.1.0 - CI Build 150

IDEA4RC FHIR Implementation Guide, published by IDEA4RC Project. This guide is not an authorized publication; it is the continuous build for version 0.1.0 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/hl7-eu/idea4rc/ and changes regularly. See the Directory of published versions

Logical Model: CancerEpisodeI4rc - Detailed Descriptions

Draft as of 2024-11-12

Definitions for the CancerEpisode logical model.

Guidance on how to interpret the contents of this table can be found here

0. CancerEpisode
Definition

Cancer Episode Maturity Level: 0 Draft

ShortCancer Episode
Logical ModelInstances of this logical model are not marked to be the target of a Reference
2. CancerEpisode.patient
Definition

Patient element containing the data regarding the patient followed by the hospital

ShortPatient
Control1..1
Typehttp://hl7.eu/fhir/ig/idea4rc/StructureDefinition/Subject
Obligations
    ObligationsActor
    SHALL:handle
    SHALL:handle
    4. CancerEpisode.dateOfDiagnosis
    Definition

    Date of the procedure from which the specimen was obtained that allowed the histological diagnosis.

    ShortDate of diagnosis (biopsy or surgical piece)
    Control1..1
    Typedate
    Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
    Obligations
      ObligationsActor
      SHALL:handle
      SHALL:handle
      6. CancerEpisode.typeOfBiopsy
      Definition

      Type of biopsy performed

      ShortType of biopsy
      Comments

      FNA core-trcut incisional excisional unplanned excision

      Fine needle biopsy - 4171863 Core needle biopsy - 4321878 Incisional biopsy - 4321986 Excisional biopsy - 4228202 Excision - 4279903

      Control1..1
      TypeCodeableConcept
      Obligations
        ObligationsActor
        SHALL:handle
        8. CancerEpisode.biopsyDoneBy
        Definition

        Describes the institution where diagnostic procedure was performed

        ShortBiopsy done by
        Control1..1
        Typestring
        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
        Obligations
          ObligationsActor
          SHALL:handle
          SHALL:handle
          10. CancerEpisode.ageAtDiagnosis
          Definition

          Age of the patient at the time of the diagnosis.

          ShortAge at diagnosis
          Control1..1
          Typeinteger
          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
          Obligations
            ObligationsActor
            SHALL:handle
            SHALL:handle
            12. CancerEpisode.radiotherapyInducedSarcoma
            Definition

            radiotherapy induced if the new tumour is in the field or marginal the anatomical area that received high radiation dose; please specify the interval time from the radiotherapy treatment

            ShortRadiotherapy induced sarcoma
            Comments

            Radiation therapy induced change Radiation therapy induced change - 37117814

            Control1..1
            Typeboolean
            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
            Obligations
              ObligationsActor
              SHALL:handle
              14. CancerEpisode.grading
              Definition

              Grading of the cancer

              ShortGrading
              Comments

              1 2 3 high low Grade-1 - 1634371 Grade-2 - 1634752 Grade-3 - 1633749 Grade-H - 1635587 Grade-L - 1634085

              Control0..1
              TypeCodeableConcept
              Obligations
                ObligationsActor
                SHALL:handle
                SHALL:handle
                16. CancerEpisode.hnClassification
                Definition

                Classification for Head and Neck tumors

                ShortClassification for Head and Neck tumors
                Comments

                Added to the model for grouping elements

                Control1..1
                TypeBackboneElement
                Obligations
                  ObligationsActor
                  SHALL:handle
                  SHALL:handle
                  18. CancerEpisode.hnClassification.histologySquamous
                  Definition

                  Specifies the histological subgroup for squamous cancers

                  ShortHistology Squamous
                  Comments

                  Keratinizing squamous cell carcinoma, epidermoid carcinoma; Non-keratinizing squamous cell carcinoma; Non-keratinizing squamous cell carcinoma: SMARCB1 (INI-1)-deficient Sinonasal Carcinoma ;Non-keratinizing squamous cell carcinoma: Transitional (cylindrical cell, Schneiderian) carcinoma ;Spindle cell (sarcomatoid) squamous cell carcinoma;Spindle cell (sarcomatoid) squamous cell carcinoma: SMARCB1 (INI-1)-deficient Sinonasal Carcinoma ;Lymphoepithelial carcinoma, lymphoepithelioma like carcinoma;Basaloid squamous cell carcinoma;Squamous cell carcinoma: conventional, NOS, clear cell, microinvasive, adenoid, acantholytic, pseudoglandular, giant cell ;Verrucous squamous cell carcinoma: NOS, cuniculatum carcinoma/Ackerman tumor; Papillary squamous cell carcinoma; Squamous cell carcinoma; Squamous cell carcinoma: HPV-positive; Squamous cell carcinoma: HPV-negative
                  Keratinizing squamous cell carcinoma, epidermoid carcinoma - 4078953 Non-keratinizing squamous cell carcinoma - 4147603 Non-keratinizing squamous cell carcinoma: SMARCB1 (INI-1)-deficient Sinonasal Carcinoma - (This should be a modifier? not clear) Non-keratinizing squamous cell carcinoma: Transitional (cylindrical cell, Schneiderian) carcinoma - 4206785 Spindle cell (sarcomatoid) squamous cell carcinoma - 4277415 Spindle cell (sarcomatoid) squamous cell carcinoma: SMARCB1 (INI-1)-deficient Sinonasal Carcinoma - (This should be a modifier? not clear) Lymphoepithelial carcinoma, lymphoepithelioma like carcinoma - 4247661 Basaloid squamous cell carcinoma - 4029973 Squamous cell carcinoma: conventional, NOS, clear cell, microinvasive, adenoid, acantholytic, pseudoglandular, giant cell Verrucous squamous cell carcinoma: NOS, cuniculatum carcinoma/Ackerman tumor - 4298030 Papillary squamous cell carcinoma - 4191609 Squamous cell carcinoma - 4103543 Squamous cell carcinoma: HPV-positive - 37204531 Squamous cell carcinoma: HPV-negative - 37204532

                  Control1..1
                  TypeCodeableConcept
                  Obligations
                    ObligationsActor
                    SHALL:handle
                    SHALL:handle
                    20. CancerEpisode.hnClassification.histologyAdenocarcinoma
                    Definition

                    Specifies the histological subgroup for adenocarcinomas

                    ShortHistology Adenocarcinoma
                    Comments

                    Intestinal-type (sinonasal) adenocarcinoma; NOS, non?intestinal-type (sinonasal), Endolymphatic sac low grade, Intestinal-type (salivary gland), cystoadenocarcinoma, mucinous, Ceruminous (only in ear); Nasopharyngeal papillary adenocarcinoma, thyroid like low grade nasopharingeal papillary adenocarcinoma; Adenoid cystic carcinoma; Adenoid cystic carcinoma: solid type (> 30% solid); Mucoepidermoid carcinoma; Polymorphous, Cribriform of minor salivary glands, Polymorphous (low grade), terminal duct carcinoma, lobular carcinoma; Acinic cell carcinoma;Clear cell carcinoma, hyalinising clear cell carcinoma; Basal cell adenocarcinoma, malignant dermal analog tumor;Salivary duct carcinoma, high grade ductal carcinoma;Salivary secretory adenocarcinoma (mammary analog, MASC); Secretory carcinoma; Myoepithelial carcinoma, malignant myoepithelioma; Carcinoma ex pleomorphic adenoma: NOS, Intracapsular, minimally invasive, largely invasive; Sebaceous adenocarcinoma, Sebaceous lymphadenocarcinoma; Carcinosarcoma; Oncocytic carcinoma, oxyphilic carcinoma, oncocytic adenocarcinoma, oncocytic malignant oncocytoma; Salivary gland intraductal carcinoma (cribriform low grade adenocarcinoma)
                    Intestinal-type (sinonasal) adenocarcinoma - CHECK WHICH SON NOS, non?intestinal-type (sinonasal) - FROM HERE?, Endolymphatic sac low grade, Intestinal-type (salivary gland) - 4312929, cystoadenocarcinoma - 4050978, mucinous - 4247921, Ceruminous (only in ear) - 4238334 Nasopharyngeal papillary adenocarcinoma - 605208, thyroid like low grade nasopharingeal papillary adenocarcinoma Adenoid cystic carcinoma - 4022895 Adenoid cystic carcinoma: solid type (> 30% solid) Mucoepidermoid carcinoma - 4253608 Polymorphous Cribriform of minor salivary glands - THERE IS NO MINOR BUT MAJOR SALIVARY GLANDS Polymorphous (low grade) - 4030121 terminal duct carcinoma - NOT SURE lobular carcinoma - 4232456 Acinic cell carcinoma - 4164740 Clear cell carcinoma - 4148292, hyalinising clear cell carcinoma Basal cell adenocarcinoma - 4146684 malignant dermal analog tumor - NOT SURE Salivary duct carcinoma - 4287334 high grade ductal carcinoma Salivary secretory adenocarcinoma (mammary analog, MASC) - 37116978 Secretory carcinoma - LOOKS LIKE NO MAPPING IN SNOMED Myoepithelial carcinoma, malignant myoepithelioma - 4029680 Carcinoma ex pleomorphic adenoma: NOS, Intracapsular, minimally invasive, largely invasive Sebaceous adenocarcinoma - 4182993 Sebaceous lymphadenocarcinoma - 37116976 Carcinosarcoma - 4271564 Oncocytic carcinoma oxyphilic carcinoma - 4212379 oncocytic adenocarcinoma oncocytic malignant oncocytoma Salivary gland intraductal carcinoma (cribriform low grade adenocarcinoma)

                    Control1..1
                    TypeCodeableConcept
                    Obligations
                      ObligationsActor
                      SHALL:handle
                      SHALL:handle
                      22. CancerEpisode.hnClassification.histologyNeuroendocrine
                      Definition

                      Specifies the histological subgroup for neuroendocrine cancers

                      ShortHistology Neuroendocrine
                      Comments

                      Small cell neuroendocrine�carcinoma (SmCC)?,Poorly differentiated neuroendocrine carcinoma, small cell (grade 3);Large cell neuroendocrine carcinoma (LCNEC)?, Poorly differentiated neuroendocrine carcinoma, large cell (grade 3);Well-differentiated neuroendocrine carcinoma, Middle ear carcinoid tumor;Moderately differentiated neuroendocrine carcinoma Small cell neuroendocrine�carcinoma (SmCC)? - 36714029 Poorly differentiated neuroendocrine carcinoma - 37018672 small cell (grade 3) Large cell neuroendocrine carcinoma (LCNEC)? - 4029971 Poorly differentiated neuroendocrine carcinoma, large cell (grade 3) Well-differentiated neuroendocrine carcinoma, Middle ear carcinoid tumor Moderately differentiated neuroendocrine carcinoma

                      Control1..1
                      TypeCodeableConcept
                      Obligations
                        ObligationsActor
                        SHALL:handle
                        SHALL:handle
                        24. CancerEpisode.hnClassification.histologyOdontogenicCarcinoma
                        Definition

                        Specifies the histological subgroup for odontogenic carcinomas

                        ShortHistology Odontogenic Carcinoma
                        Comments

                        Odontogenic carcinoma, NOS, Ameloblastic carcinoma (primary, secondary intraosseous, secondary peripheral), Primary intraosseous carcinoma, Intraosseous carcinoma developed on odontogenic cyst, sclerosing odontogenic carcinoma; Clear cell odontogenic carcinoma; Gosht cell odontogenic carcinoma Odontogenic carcinoma, NOS - 4098585 Ameloblastic carcinoma (primary, secondary intraosseous, secondary peripheral) - 37116638 Secondary dedifferentiated intraosseous ameloblastic carcinoma

                        • 37116980 Secondary dedifferentiated peripheral ameloblastic carcinoma - 37116979 Primary intraosseous carcinoma - 37117009 Intraosseous carcinoma developed on odontogenic cyst - 37116887 sclerosing odontogenic carcinoma Clear cell odontogenic carcinoma - 734032001 Gosht cell odontogenic carcinoma - 37312303
                        Control1..1
                        TypeCodeableConcept
                        Obligations
                          ObligationsActor
                          SHALL:handle
                          SHALL:handle
                          26. CancerEpisode.hnClassification.histologySNUC
                          Definition

                          Specifies the histological subgroup for sinonasl undifferentiated carcinomas

                          ShortHistology Sinonasal undifferentiated carcinoma
                          Comments

                          SMARCB1 (INI-1)-deficient Sinonasal undifferentiated Carcinoma;Sinonasal SMARCA4 deficient carcinoma;IDH2-mutated sinonasal undifferentiated neoplasm SMARCB1 (INI-1)-deficient Sinonasal undifferentiated Carcinoma Sinonasal SMARCA4 deficient carcinoma IDH2-mutated sinonasal undifferentiated neoplasm

                          Control1..1
                          TypeCodeableConcept
                          Obligations
                            ObligationsActor
                            SHALL:handle
                            SHALL:handle
                            28. CancerEpisode.sarcomaClassification
                            Definition

                            Sarcoma classification

                            ShortSarcoma classification
                            Control1..1
                            TypeBackboneElement
                            Obligations
                              ObligationsActor
                              SHALL:handle
                              30. CancerEpisode.sarcomaClassification.adipocyticTumours
                              Definition

                              Specifies the histological subgroup for adipocytic tumours

                              ShortHistology subgroup Adipocytic tumours
                              Comments

                              Atypical lipomatous tumour/ Liposarcoma, well-differentiated, NOS Dedifferentiated liposarcoma Myxoid liposarcoma Pleomorphic liposarcoma Myxoid pleomorphic liposarcoma

                              Liposarcoma, well differentiated - 4102790 Dedifferentiated liposarcoma - 4284833 Myxoid liposarcoma - 4101123 Pleomorphic liposarcoma - 4010104 Myxoid pleomorphic liposarcoma - 4300687

                              Control1..1
                              TypeCodeableConcept
                              Obligations
                                ObligationsActor
                                SHALL:handle
                                32. CancerEpisode.sarcomaClassification.fmtTumours
                                Definition

                                Histology subgroup Fibroblastic and myofibroblastic tumours

                                ShortHistology subgroup Fibroblastic and myofibroblastic tumours
                                Comments

                                Palmar/plantar-type fibromatosis Desmoid-type fibromatosis Lipofibromatosis Giant cell fibroblastoma Dermatofibrosarcoma protuberans NOS Solitary fibrous tumour, benign; NOS; malignant Inflammatory myofibroblastic tumour Low-grade myofibroblastic sarcoma Superficial CD34-positive fibroblastic tumour Myxoinflammatory fibroblastic sarcoma Infantile fibrosarcoma Adult fibrosarcoma Myxofibrosarcoma Low-grade fibromyxoid sarcoma Sclerosing epithelioid fibrosarcoma

                                Palmar/plantar-type fibromatosis - 45766452 Desmoid-type fibromatosis - 4264204 Lipofibromatosis - 45766468 Giant cell fibroblastoma - 4030132 Dermatofibrosarcoma protuberans - 4295283 Solitary fibrous tumor - 4030130 Solitary fibrous tumor, malignant - 4028562 Myofibroblastic tumour - 4021373 Low-grade myofibroblastic sarcoma - 45766454 Cellular fibroma - 4029679 Myxoinflammatory fibroblastic sarcoma - 45766450 Infantile fibrosarcoma - 4178132 Fibrosarcoma - 4202374 Myxofibrosarcoma - 45771359 Low-grade fibromyxoid sarcoma - 45771361 Sclerosing epithelioid fibrosarcoma - 45766456

                                Control1..1
                                TypeCodeableConcept
                                Obligations
                                  ObligationsActor
                                  SHALL:handle
                                  34. CancerEpisode.sarcomaClassification.socalledFibrohistiocyticTumours
                                  Definition

                                  Histology subgroup So-called fibrohistiocytic tumours

                                  ShortHistology subgroup So-called fibrohistiocytic tumours
                                  Comments

                                  Plexiform fibrohistiocytic tumour Giant cell tumour of soft parts NOS Tenosynovial giant cell tumor

                                  Plexiform fibrohistiocytic tumour - 4029525 Giant cell tumour of soft parts - 4218898 Tenosynovial giant cell tumor - 4030140 Tenosynovial giant cell tumor, diffuse - 45766525 Malignant tenosynovial giant cell tumor - 4029655

                                  Control1..1
                                  TypeCodeableConcept
                                  Obligations
                                    ObligationsActor
                                    SHALL:handle
                                    36. CancerEpisode.sarcomaClassification.vascularTumours
                                    Definition

                                    Vascular tumours

                                    ShortVascular tumours
                                    Comments

                                    Epithelioid haemangioendothelioma NOS Angiosarcoma Kaposiform haemangioendothelioma ha anche la forma benigna 9161/0 Acquired tufted haemangioma. teniamo anche la fomra benigna? Retiform haemangioendothelioma Papillary intralymphatic angioendothelioma Composite haemangioendothelioma Pseudomyogenic (epithelioid sarcoma?like) haemangioendothelioma

                                    Epithelioid haemangioendothelioma - 4207381 Angiosarcoma - 3661612 Hemangioendothelioma - 4281384 Retiform haemangioendothelioma - 45766493 Endovascular papillary angioendothelioma - 4030138 Composite haemangioendothelioma - 45766494 Pseudomyogenic (epithelioid sarcoma-like) hemangioendothelioma - 45766492

                                    Control1..1
                                    TypeCodeableConcept
                                    Obligations
                                      ObligationsActor
                                      SHALL:handle
                                      38. CancerEpisode.sarcomaClassification.pericyticPerivascularTumours
                                      Definition

                                      Pericytic (perivascular) tumours

                                      ShortPericytic (perivascular) tumours
                                      Comments

                                      Glomus tumour NOS

                                      Glomus tumour - 40571984

                                      Control1..1
                                      TypeCodeableConcept
                                      Obligations
                                        ObligationsActor
                                        SHALL:handle
                                        40. CancerEpisode.sarcomaClassification.smoothMuscleTumours
                                        Definition

                                        Smooth muscle tumours

                                        ShortSmooth muscle tumours
                                        Comments

                                        Smooth muscle tumour of uncertain malignant potential Epithelioid smooth muscle tumor of uncertain malignant potential Myxoid smooth muscle tumour of uncertain mailgnant potential-Spindle smooth muscle tumor of uncertain malignant potential Metastasizing leiomyoma Leiomyosarcoma NOS Epithelioid leiomyosarcoma Myxoid leiomyosarcoma Metastasizing leiomyoma

                                        Smooth muscle tumour - 4327493 Epithelioid smooth muscle tumor of uncertain malignant potential - 607803 Myxoid smooth muscle tumour of uncertain mailgnant potential - 600675 Spindle smooth muscle tumor of uncertain malignant potential Metastasizing leiomyoma - 4029023 Leiomyosarcoma - 4201415 Epithelioid leiomyosarcoma - 4173148 Myxoid leiomyosarcoma - 4059632 Metastasizing leiomyoma - 4029023

                                        Control1..1
                                        TypeCodeableConcept
                                        Obligations
                                          ObligationsActor
                                          SHALL:handle
                                          42. CancerEpisode.sarcomaClassification.skeletalMuscleTumours
                                          Definition

                                          Skeletal muscle tumours

                                          ShortSkeletal muscle tumours
                                          Comments

                                          Embryonal rhabdomyosarcoma NOS Alveolar rhabdomyosarcoma Pleomorphic rhabdomyosarcoma NOS Spindle cell / sclerosing rhabdomyosarcoma Ectomesenchymoma

                                          Embryonal rhabdomyosarcoma - 4031038 Alveolar rhabdomyosarcoma - 4272931 Pleomorphic rhabdomyosarcoma - 4298312 Spindle cell rhabdomyosarcoma - 4029528 Rhabdomyosarcoma with ganglionic differentiation - 4029024

                                          Control1..1
                                          TypeCodeableConcept
                                          Obligations
                                            ObligationsActor
                                            SHALL:handle
                                            44. CancerEpisode.sarcomaClassification.chondroOsseousTumours
                                            Definition

                                            Chondro-osseous tumours

                                            ShortChondro-osseous tumours
                                            Comments

                                            Extraskeletal osteosarcoma

                                            Extraskeletal osteosarcoma - 4298240

                                            Control1..1
                                            TypeCodeableConcept
                                            Obligations
                                              ObligationsActor
                                              SHALL:handle
                                              46. CancerEpisode.sarcomaClassification.peripheralNerveSheathTumours
                                              Definition

                                              Peripheral nerve sheath tumours

                                              ShortPeripheral nerve sheath tumours
                                              Comments

                                              Malignant peripheral nerve sheath tumour NOS Malignant melanotic nerve sheath tumour Granular cell tumour NOS Granular cell tumour, malignant

                                              Malignant peripheral nerve sheath tumour - 4062426 Melanotic malignant peripheral nerve sheath tumor - 4102399 Granular cell tumour - 4005360 Granular cell tumour, malignant - 4027842

                                              Control1..1
                                              TypeCodeableConcept
                                              Obligations
                                                ObligationsActor
                                                SHALL:handle
                                                48. CancerEpisode.sarcomaClassification.tumoursOfUncertainDifferentiation
                                                Definition

                                                Tumours of uncertain differentiation

                                                ShortTumours of uncertain differentiation
                                                Comments

                                                Atypical fibroxanthoma Angiomatoid fibrous histiocytoma Pleomorphic hyalinizing angiectatic tumour Haemosiderotic fibrolipomatous tumour NTRK-rearranged spindle cell neoplasms Synovial sarcoma NOS Epithelioid sarcoma Alveolar soft part sarcoma Clear cell sarcoma NOS Extra-skeletal myxoid chondrosarcoma Desmoplastic small round cell tumour Extra-renal rhabdoid tumour NOS PEComas Intimal sarcoma Undifferentiated sarcoma Myoepithelioma Ossifying fibromyxoid tumour Phosphaturic mesenchymal tumour, malignant Aggressive angiomyxoma Angiomatoid fibrous histiocytoma NTRK-rearranged spindle cell neoplasm (emerging)

                                                    Atypical fibrous histiocytoma - 4096931
                                                

                                                Angiomatoid fibrous histiocytoma - 4029526 Pleomorphic hyalinizing angiectatic tumour - 45766448 Haemosiderotic fibrolipomatous tumour NTRK-rearranged spindle cell neoplasms - CUSTOM CODE Synovial sarcoma - 4268491 Epithelioid sarcoma - 4244886 Alveolar soft part sarcoma - 4339208 Clear cell sarcoma - 4155072 Myxoid chondrosarcoma - 4328092 Desmoplastic small round cell tumor - 4029522 Malignant rhabdoid tumor - 4307938 Perivascular epithelioid tumor, benign - 45771358 Perivascular epithelioid tumor, malignant - 45766447 Perivascular epithelioid cell tumor - 4304780 Intimal sarcoma - 45766495 Undifferentiated sarcoma - 4029021 Myoepithelioma - 4239519 Ossifying fibromyxoid tumour - 4028565 Phosphaturic mesenchymal tumour, malignant - 45766485 Aggressive angiomyxoma - 4239956 Angiomatoid fibrous histiocytoma - 4029526 NTRK-rearranged spindle cell neoplasm (emerging)

                                                Control1..1
                                                TypeCodeableConcept
                                                Obligations
                                                  ObligationsActor
                                                  SHALL:handle
                                                  50. CancerEpisode.sarcomaClassification.undifSmallRCelSarcBonAndSofTis
                                                  Definition

                                                  Undifferentiated small round cell sarcomas of bone and soft tissue

                                                  ShortUndifferentiated small round cell sarcomas of bone and soft tissue
                                                  Comments

                                                  Ewing sarcoma Round cell sarcoma with�EWSR1?non-ETS fusions CIC-rearranged sarcoma Sarcoma with�BCOR�genetic alterations

                                                  Ewing sarcoma - 45766528 Round cell sarcoma with�EWSR1?non-ETS fusions CIC-rearranged sarcoma Sarcoma with�BCOR�genetic alterations

                                                  Control1..1
                                                  TypeCodeableConcept
                                                  Obligations
                                                    ObligationsActor
                                                    SHALL:handle
                                                    52. CancerEpisode.sarcomaClassification.estAndRelatedTumours
                                                    Definition

                                                    Endometrial stromal and related tumours

                                                    ShortEndometrial stromal and related tumours
                                                    Comments

                                                    Endometrial stromal sarcoma, high grade Endometrial stromal sarcoma, low grade

                                                    Endometrial stromal sarcoma, high grade - 4290926 Endometrial stromal sarcoma, low grade - 4028557

                                                    Control1..1
                                                    TypeCodeableConcept
                                                    Obligations
                                                      ObligationsActor
                                                      SHALL:handle
                                                      54. CancerEpisode.sarcomaClassification.miscellaniousMesenchimalTumors
                                                      Definition

                                                      Miscellanious mesenchimal tumors

                                                      ShortMiscellanious mesenchimal tumors
                                                      Comments

                                                      Uterine tumour resembling ovarian sex cord tumour Phyllodes tumour, benign Phyllodes tumour NOS Phyllodes tumour, borderline Phyllodes tumour, malignant Follicular dendritic cell sarcoma Histiocytic sarcoma Interdigitating dendritic cell sarcoma Langherans cell sarcoma Fibroblastic reticular cell tumour Biphenotypic sinonasal sarcoma

                                                      Uterine tumour resembling ovarian sex cord tumour - 45771357 Benign phyllodes tumor - 4040991 Borderline phyllodes tumor - 4323562 Phyllodes tumour, malignant - 4337106 Follicular dendritic cell sarcoma - 4028710 Histiocytic sarcoma - 4029172 Interdigitating dendritic cell sarcoma - 4028709 Langherans cell sarcoma - 4029173 Fibroblastic reticular cell tumour - 42872917 Biphenotypic sinonasal sarcoma - 37311513

                                                      Control1..1
                                                      TypeCodeableConcept
                                                      Obligations
                                                        ObligationsActor
                                                        SHALL:handle
                                                        56. CancerEpisode.sarcomaClassification.mixedEpithelialAndMesenchymalTumours
                                                        Definition

                                                        Mixed epithelial and mesenchymal tumours

                                                        ShortMixed epithelial and mesenchymal tumours
                                                        Comments

                                                        Adenosarcoma; please clarify if adenosarcoma with sarcomatous overgrowth

                                                        Adenosarcoma - 4135215

                                                        Control1..1
                                                        TypeCodeableConcept
                                                        Obligations
                                                          ObligationsActor
                                                          SHALL:handle
                                                          58. CancerEpisode.subsites
                                                          Definition

                                                          subsites

                                                          Shortsubsites
                                                          Control1..1
                                                          TypeBackboneElement
                                                          Obligations
                                                            ObligationsActor
                                                            SHALL:handle
                                                            60. CancerEpisode.subsites.nasalCavityAndParanasalSinuses
                                                            Definition

                                                            Specifies the subsite for cancers occurred in nasal cavity and paranasal sinusess

                                                            ShortNasal cavity and paranasal sinuses subsite
                                                            Comments

                                                            AJCC 8th Edition Cancer Staging Manual

                                                            Nasal cavity;Maxillary sinus;Ethmoid sinus;Frontal sinus;Sphenoid sinus Nasal cavity - 4088327 Maxillary sinus - 4050631 Ethmoid sinus - 4182234 Frontal sinus - 4204534 Sphenoid sinus - 4097172

                                                            Control1..1
                                                            TypeCodeableConcept
                                                            Obligations
                                                              ObligationsActor
                                                              SHALL:handle
                                                              62. CancerEpisode.subsites.nasopharynx
                                                              Definition

                                                              Specifies the subsite for cancers occurred in nasopharynx

                                                              ShortNasopharynx subsite
                                                              Comments

                                                              AJCC 8th Edition Cancer Staging Manual

                                                              Superior wall of nasopharynx;Posterior wall of nasopharynx;Lateral wall of nasopharynx;Anterior wall of nasopharynx Superior wall of nasopharynx - 4068978 Posterior wall of nasopharynx - 4146741 Lateral wall of nasopharynx - 4323979 Anterior wall of nasopharynx - 4220236

                                                              Control1..1
                                                              TypeCodeableConcept
                                                              Obligations
                                                                ObligationsActor
                                                                SHALL:handle
                                                                64. CancerEpisode.subsites.hypopharynx
                                                                Definition

                                                                Specifies the subsite for cancers occurred in hypopharynx

                                                                ShortHypopharynx subsite
                                                                Comments

                                                                AJCC 8th Edition Cancer Staging Manual

                                                                Postcricoid region; Hypopharyngeal aspect of aryepiglottic fold; Posterior wall of hypopharynx;Pyriform sinus

                                                                Postcricoid region - 4147741 Hypopharyngeal aspect of aryepiglottic fold - 4262980 Posterior wall of hypopharynx - 4102600 Pyriform sinus - 4268741

                                                                Control1..1
                                                                TypeCodeableConcept
                                                                Obligations
                                                                  ObligationsActor
                                                                  SHALL:handle
                                                                  66. CancerEpisode.subsites.oropharynx
                                                                  Definition

                                                                  Specifies the subsite for cancers occurred in oropharynx

                                                                  ShortOropharynx subsite
                                                                  Comments

                                                                  https://link.springer.com/book/9783319406176

                                                                  Base of tongue, NOS; Soft palate NOS (excludes Nasopharyngcal surface C11.3); Uvula; Tonsillar fossa; Lingual tonsil; Tonsillar pillar; Vallecula; Anterior surface of epiglottis; Lateral wall oropharynx; Posterior wall oropharynx; Branchial cleft (site of neoplosm);

                                                                  Base of tongue, NOS - 4169910 Soft palate NOS (excludes Nasopharyngcal surface C11.3) - 4177005 Uvula - 4095284 Tonsillar fossa - 4138234 Lingual tonsil - 4068841 Tonsillar pillar - 4065073 Vallecula - 4173123 Anterior surface of epiglottis - 4283238 Lateral wall oropharynx - 4078066 Posterior wall oropharynx - 4045435 Branchial cleft (site of neoplosm) - 4235649

                                                                  Control1..1
                                                                  TypeCodeableConcept
                                                                  Obligations
                                                                    ObligationsActor
                                                                    SHALL:handle
                                                                    68. CancerEpisode.subsites.larynx
                                                                    Definition

                                                                    Specifies the subsite for cancers occurred in larynx

                                                                    ShortLarynx subsite
                                                                    Comments

                                                                    AJCC 8th Edition Cancer Staging Manual Glottis;Supraglottis;Subglottis;Laryngeal cartilage

                                                                    Glottis - 4047227 Supraglottis - 4001049 Subglottis - 4002724 Laryngeal cartilage - 4279711

                                                                    Control1..1
                                                                    TypeCodeableConcept
                                                                    Obligations
                                                                      ObligationsActor
                                                                      SHALL:handle
                                                                      70. CancerEpisode.subsites.oralCavity
                                                                      Definition

                                                                      Specifies the subsite for cancers occurred in oral cavity

                                                                      ShortOral cavity subsite
                                                                      Comments

                                                                      AJCC 8th Edition Cancer Staging Manual

                                                                      Dorsal surface tongue, NOS; Border of tongue; Ventral surface of tongue NOS; Anterior 2/3 of tongue NOS; Upper gum; Lower gum; Anterior floor of mouth; Lateral floor of mouth; Overlapping lesion of floor of mouth; Hard palate; Cheek mucosa; Vestibule of mouth; Retromolar area; Overlapping lesion of other and unspecified parts of mouth; Dorsal surface tongue, NOS - 36769609 Border of tongue - 4077986 Ventral surface of tongue - 4172794 Anterior 2/3 of tongue NOS Upper gum - 4047029 Lower gum - 4210919 Anterior floor of mouth - 4181419 Lateral floor of mouth - 4103066 Overlapping lesion of floor of mouth - 44498040 Hard palate - 4234542 Cheek mucosa - 4057160 Vestibule of mouth - 4144069 Retromolar area - 36769865 Overlapping lesion of other and unspecified parts of mouth -

                                                                      Control1..1
                                                                      TypeCodeableConcept
                                                                      Obligations
                                                                        ObligationsActor
                                                                        SHALL:handle
                                                                        72. CancerEpisode.subsites.lip
                                                                        Definition

                                                                        Specifies the subsite for cancers occurred in lip

                                                                        ShortLip subsite
                                                                        Comments

                                                                        AJCC 8th Edition Cancer Staging Manual

                                                                        External lower lip;External upper lip;External lip, NOS;Mucosa of upper lip;Mucosa of lower lip;Mucosa of lip, NOS;Commissure of lip External lower lip - 4027546 External upper lip - 4134589 External lip, NOS - 4027545 Mucosa of upper lip - 36769700 Mucosa of lower lip - 36768548 Mucosa of lip, NOS - 4245168 Commissure of lip - 4307358

                                                                        Control1..1
                                                                        TypeCodeableConcept
                                                                        Obligations
                                                                          ObligationsActor
                                                                          SHALL:handle
                                                                          74. CancerEpisode.subsites.upperAndLowerLimbs
                                                                          Definition

                                                                          Specifies the subsite for cancers occurred in

                                                                          ShortUpper and Lower limbs subsite
                                                                          Comments

                                                                          Hand Wrist Forearm Elbow/Antecubital fossa Upper arm Foot Ankle Leg Knee/popliteal fossa Upper leg Deltoid Supraclavicular Periscapular Trapezius Groin Buttock Pectoral Axilla

                                                                          Hand structure - 4310976 Wrist region structure - 4220073 Forearm structure - 4032953 Elbow region structure - 4027910 Antecubital fossa (surface region) - 4348994 Upper arm structure - 4165266 Foot structure- 4211098 Ankle region structure - 4142359 Lower leg structure - 4107527 Knee region structure - 4217806 popliteal fossa structure - 4138531 Upper leg - 4090445 Deltoid - 4291935 Supraclavicular - 4088464 Periscapular region - 42605854 Trapezius - 4136969 Groin - 4109459 Buttock - 4263335 Pectoral - 4096078 Axilla - 4157836

                                                                          Control1..1
                                                                          TypeCodeableConcept
                                                                          Obligations
                                                                            ObligationsActor
                                                                            SHALL:handle
                                                                            76. CancerEpisode.subsites.trunkWallSubsite
                                                                            Definition

                                                                            Specifies the subsite for cancers occurred in

                                                                            ShortTrunk wall subsite
                                                                            Comments

                                                                            Thoracic Wall Abdominal Wall Paravertebral ? thoracolumbar Paravertebral ? cervical

                                                                            Joint structure of thoracic wall - 4088614 Anterior abdominal wall structure - 4244412 Posterior abdominal wall structure - 4330865 Paravertebral ? thoracolumbar - Paravertebral ? cervical

                                                                            Control1..1
                                                                            TypeCodeableConcept
                                                                            Obligations
                                                                              ObligationsActor
                                                                              SHALL:handle
                                                                              78. CancerEpisode.subsites.intraAbdominalSubsite
                                                                              Definition

                                                                              Specifies the subsite for cancers occurred in

                                                                              ShortIntra abdominal subsite
                                                                              Comments

                                                                              Retroperitoneum Vessels (please select: inferior vena cava, aorta, iliac vessels, renal vessels, gonadal vessels, mesenteric vessels, others) Pelvis Esophagus Stomach Duodenum Jejunum/Ileus Colon Rectum Mesentery

                                                                              Retroperitoneal compartment structure - 4220536 Vessels (please select: inferior vena cava, aorta, iliac vessels, renal vessels, gonadal vessels, mesenteric vessels, others) Inferior vena cava structure - 4271699 Iliac vessel - 4193451 Structure of renal artery - 4154880 Gonadal artery - 4157844 Structure of mesenteric artery - 4314264 Other vessels - WILDCARD* Renal pelvis structure - 4094242 Major pelvis structure - 4229753 Region of esophagus - 4075991 Stomach - 4288283 Duodenal structure - 4302112 Jejunal structure - 4065077 Stricture of ileum - 4316356 Colon structure - 4215634 Rectum structure - 4144541 Mesentery - 4233095

                                                                              Control1..1
                                                                              TypeCodeableConcept
                                                                              Obligations
                                                                                ObligationsActor
                                                                                SHALL:handle
                                                                                80. CancerEpisode.subsites.intraThoracicSubsite
                                                                                Definition

                                                                                Specifies the subsite for cancers occurred in

                                                                                ShortIntra thoracic subsite
                                                                                Comments

                                                                                Lung Heart Pleura Mediastinum Great vessels (please select: superior vena cava, aorta, pulmonary vessels, subclavian vessels, others)

                                                                                Lung structure - 4213162 Heart structure - 4217142 Pleura structure - 4150673 Region of mediastinum - 4088610 Great vessels (please select: superior vena cava, aorta, pulmonary vessels, subclavian vessels, others) Superior vena cava structure - 4167648 Aorta part - 4001033 Stricture of pulmonary vessel - 4035327 Structure of subclavian artery - 4272388 Other - WILDCARD

                                                                                Control1..1
                                                                                TypeCodeableConcept
                                                                                Obligations
                                                                                  ObligationsActor
                                                                                  SHALL:handle
                                                                                  82. CancerEpisode.subsites.genitoUrinarySubsite
                                                                                  Definition

                                                                                  Specifies the subsite for cancers occurred in

                                                                                  ShortGenito urinary subsite
                                                                                  Comments

                                                                                  Adrenal glands Kidney Urether Bladder Prostate Seminal Vescicle Spermatic Cord Testis Penis Utero Ovary Fallopian tube Vagina Vulva

                                                                                  Bilateral adrenal glands - 4047078 Kidney structure - 4271678 Region of ureter - 4078617 Urinary bladder structure - 4232481 Structure of lobe of prostate - 4034365 Seminal Vescicle structure - 4277442 Spermatic Cord structure - 4172591 Testis structure - 4238088 Penile structure - 4077311 Uterine structure - 4149192 Ovarian structure - 4049448 Fallopian tube structure - 4151444 Vaginal structure - 4296022 Vulval structure - 4166066

                                                                                  Control1..1
                                                                                  TypeCodeableConcept
                                                                                  Obligations
                                                                                    ObligationsActor
                                                                                    SHALL:handle
                                                                                    84. CancerEpisode.subsites.headAndNeckSubsite
                                                                                    Definition

                                                                                    Specifies the subsite for cancers occurred in

                                                                                    ShortHead and Neck subsite
                                                                                    Comments

                                                                                    Head and neck Face and/or neck structure - 4122633

                                                                                    Control1..1
                                                                                    TypeCodeableConcept
                                                                                    Obligations
                                                                                      ObligationsActor
                                                                                      SHALL:handle
                                                                                      86. CancerEpisode.subsites.breast
                                                                                      Definition

                                                                                      Specifies the subsite for cancers occurred in

                                                                                      ShortBreast subsite
                                                                                      Comments

                                                                                      Breast Breast structure - 4298444

                                                                                      Control1..1
                                                                                      TypeCodeableConcept
                                                                                      Obligations
                                                                                        ObligationsActor
                                                                                        SHALL:handle
                                                                                        88. CancerEpisode.subsites.others
                                                                                        Definition

                                                                                        Specifies the subsite for cancers occurred in

                                                                                        ShortOther subsite
                                                                                        Control1..1
                                                                                        TypeCodeableConcept
                                                                                        Obligations
                                                                                          ObligationsActor
                                                                                          SHALL:handle
                                                                                          90. CancerEpisode.tumorSize
                                                                                          Definition

                                                                                          (the longest diameter; longest dimension between pre operatory imaging and pathological specimen) cm

                                                                                          ShortTumor Size
                                                                                          Control1..1
                                                                                          TypeQuantity
                                                                                          Obligations
                                                                                            ObligationsActor
                                                                                            SHALL:handle
                                                                                            92. CancerEpisode.depth
                                                                                            Definition

                                                                                            (for upper and lower limbs and superficial trunk) superficial (superficial tumour is located exclusively above the investing fascia without invasion of the fascia), deep (deep tumour is located beneath or invade the investing fascia). All the others are deep by definition

                                                                                            ShortDepth
                                                                                            Control1..1
                                                                                            TypeCodeableConcept
                                                                                            Obligations
                                                                                              ObligationsActor
                                                                                              SHALL:handle
                                                                                              94. CancerEpisode.biopsyMitoticCount
                                                                                              Definition

                                                                                              (Number/10HPF/1mm2, 50HPF/5mm2)

                                                                                              ShortBiopsy Mitotic count
                                                                                              Control1..1
                                                                                              TypeQuantity
                                                                                              Obligations
                                                                                                ObligationsActor
                                                                                                SHALL:handle
                                                                                                96. CancerEpisode.plasmaticEbvDnaAtBaseline
                                                                                                Definition

                                                                                                Describes the result of EBV DNA plasma testing before treatment in NPC type II and III (WHO)

                                                                                                ShortPlasmatic EBV DNA at baseline
                                                                                                Comments

                                                                                                Positive; Negative; not tested; Positive - 9191 Negative - 9189 not tested - 45878602

                                                                                                Control0..1
                                                                                                TypeCodeableConcept
                                                                                                Obligations
                                                                                                  ObligationsActor
                                                                                                  SHALL:handle
                                                                                                  98. CancerEpisode.hpvStatus
                                                                                                  Definition

                                                                                                  Describes the result of HPV tumor testing in oral carcinoma

                                                                                                  ShortHPV status
                                                                                                  Comments

                                                                                                  Positive; Negative; Not tested; Positive - 9191 Negative - 9189 not tested - 45878602

                                                                                                  Control0..1
                                                                                                  TypeCodeableConcept
                                                                                                  Obligations
                                                                                                    ObligationsActor
                                                                                                    SHALL:handle
                                                                                                    100. CancerEpisode.crpCReactiveProteinTested
                                                                                                    Definition

                                                                                                    Describes the result of C reactive protein testing

                                                                                                    ShortCRP - C reactive protein tested
                                                                                                    Comments

                                                                                                    Positive; Negative; Not tested; Positive - 9191 Negative - 9189 not tested - 45878602

                                                                                                    Control0..1
                                                                                                    TypeCodeableConcept
                                                                                                    Obligations
                                                                                                      ObligationsActor
                                                                                                      SHALL:handle

                                                                                                      Guidance on how to interpret the contents of this table can be found here

                                                                                                      0. CancerEpisode
                                                                                                      Definition

                                                                                                      Cancer Episode Maturity Level: 0 Draft

                                                                                                      ShortCancer Episode
                                                                                                      Control0..*
                                                                                                      Is Modifierfalse
                                                                                                      Logical ModelInstances of this logical model are not marked to be the target of a Reference
                                                                                                      2. CancerEpisode.patient
                                                                                                      Definition

                                                                                                      Patient element containing the data regarding the patient followed by the hospital

                                                                                                      ShortPatient
                                                                                                      Control1..1
                                                                                                      Typehttp://hl7.eu/fhir/ig/idea4rc/StructureDefinition/Subject
                                                                                                      Obligations
                                                                                                        ObligationsActor
                                                                                                        SHALL:handle
                                                                                                        SHALL:handle
                                                                                                        4. CancerEpisode.dateOfDiagnosis
                                                                                                        Definition

                                                                                                        Date of the procedure from which the specimen was obtained that allowed the histological diagnosis.

                                                                                                        ShortDate of diagnosis (biopsy or surgical piece)
                                                                                                        Control1..1
                                                                                                        Typedate
                                                                                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                        Obligations
                                                                                                          ObligationsActor
                                                                                                          SHALL:handle
                                                                                                          SHALL:handle
                                                                                                          6. CancerEpisode.typeOfBiopsy
                                                                                                          Definition

                                                                                                          Type of biopsy performed

                                                                                                          ShortType of biopsy
                                                                                                          Comments

                                                                                                          FNA core-trcut incisional excisional unplanned excision

                                                                                                          Fine needle biopsy - 4171863 Core needle biopsy - 4321878 Incisional biopsy - 4321986 Excisional biopsy - 4228202 Excision - 4279903

                                                                                                          Control1..1
                                                                                                          TypeCodeableConcept
                                                                                                          Obligations
                                                                                                            ObligationsActor
                                                                                                            SHALL:handle
                                                                                                            8. CancerEpisode.biopsyDoneBy
                                                                                                            Definition

                                                                                                            Describes the institution where diagnostic procedure was performed

                                                                                                            ShortBiopsy done by
                                                                                                            Control1..1
                                                                                                            Typestring
                                                                                                            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                            Obligations
                                                                                                              ObligationsActor
                                                                                                              SHALL:handle
                                                                                                              SHALL:handle
                                                                                                              10. CancerEpisode.ageAtDiagnosis
                                                                                                              Definition

                                                                                                              Age of the patient at the time of the diagnosis.

                                                                                                              ShortAge at diagnosis
                                                                                                              Control1..1
                                                                                                              Typeinteger
                                                                                                              Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                              Obligations
                                                                                                                ObligationsActor
                                                                                                                SHALL:handle
                                                                                                                SHALL:handle
                                                                                                                12. CancerEpisode.radiotherapyInducedSarcoma
                                                                                                                Definition

                                                                                                                radiotherapy induced if the new tumour is in the field or marginal the anatomical area that received high radiation dose; please specify the interval time from the radiotherapy treatment

                                                                                                                ShortRadiotherapy induced sarcoma
                                                                                                                Comments

                                                                                                                Radiation therapy induced change Radiation therapy induced change - 37117814

                                                                                                                Control1..1
                                                                                                                Typeboolean
                                                                                                                Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                                Obligations
                                                                                                                  ObligationsActor
                                                                                                                  SHALL:handle
                                                                                                                  14. CancerEpisode.grading
                                                                                                                  Definition

                                                                                                                  Grading of the cancer

                                                                                                                  ShortGrading
                                                                                                                  Comments

                                                                                                                  1 2 3 high low Grade-1 - 1634371 Grade-2 - 1634752 Grade-3 - 1633749 Grade-H - 1635587 Grade-L - 1634085

                                                                                                                  Control0..1
                                                                                                                  TypeCodeableConcept
                                                                                                                  Obligations
                                                                                                                    ObligationsActor
                                                                                                                    SHALL:handle
                                                                                                                    SHALL:handle
                                                                                                                    16. CancerEpisode.hnClassification
                                                                                                                    Definition

                                                                                                                    Classification for Head and Neck tumors

                                                                                                                    ShortClassification for Head and Neck tumors
                                                                                                                    Comments

                                                                                                                    Added to the model for grouping elements

                                                                                                                    Control1..1
                                                                                                                    TypeBackboneElement
                                                                                                                    Obligations
                                                                                                                      ObligationsActor
                                                                                                                      SHALL:handle
                                                                                                                      SHALL:handle
                                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                      18. CancerEpisode.hnClassification.modifierExtension
                                                                                                                      Definition

                                                                                                                      May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                                                                                                      Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                                                                                                      ShortExtensions that cannot be ignored even if unrecognized
                                                                                                                      Comments

                                                                                                                      There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                                                      Control0..*
                                                                                                                      TypeExtension
                                                                                                                      Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                                                                                                      Summarytrue
                                                                                                                      Requirements

                                                                                                                      Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                                                                                                      Alternate Namesextensions, user content, modifiers
                                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                      ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                                      20. CancerEpisode.hnClassification.histologySquamous
                                                                                                                      Definition

                                                                                                                      Specifies the histological subgroup for squamous cancers

                                                                                                                      ShortHistology Squamous
                                                                                                                      Comments

                                                                                                                      Keratinizing squamous cell carcinoma, epidermoid carcinoma; Non-keratinizing squamous cell carcinoma; Non-keratinizing squamous cell carcinoma: SMARCB1 (INI-1)-deficient Sinonasal Carcinoma ;Non-keratinizing squamous cell carcinoma: Transitional (cylindrical cell, Schneiderian) carcinoma ;Spindle cell (sarcomatoid) squamous cell carcinoma;Spindle cell (sarcomatoid) squamous cell carcinoma: SMARCB1 (INI-1)-deficient Sinonasal Carcinoma ;Lymphoepithelial carcinoma, lymphoepithelioma like carcinoma;Basaloid squamous cell carcinoma;Squamous cell carcinoma: conventional, NOS, clear cell, microinvasive, adenoid, acantholytic, pseudoglandular, giant cell ;Verrucous squamous cell carcinoma: NOS, cuniculatum carcinoma/Ackerman tumor; Papillary squamous cell carcinoma; Squamous cell carcinoma; Squamous cell carcinoma: HPV-positive; Squamous cell carcinoma: HPV-negative
                                                                                                                      Keratinizing squamous cell carcinoma, epidermoid carcinoma - 4078953 Non-keratinizing squamous cell carcinoma - 4147603 Non-keratinizing squamous cell carcinoma: SMARCB1 (INI-1)-deficient Sinonasal Carcinoma - (This should be a modifier? not clear) Non-keratinizing squamous cell carcinoma: Transitional (cylindrical cell, Schneiderian) carcinoma - 4206785 Spindle cell (sarcomatoid) squamous cell carcinoma - 4277415 Spindle cell (sarcomatoid) squamous cell carcinoma: SMARCB1 (INI-1)-deficient Sinonasal Carcinoma - (This should be a modifier? not clear) Lymphoepithelial carcinoma, lymphoepithelioma like carcinoma - 4247661 Basaloid squamous cell carcinoma - 4029973 Squamous cell carcinoma: conventional, NOS, clear cell, microinvasive, adenoid, acantholytic, pseudoglandular, giant cell Verrucous squamous cell carcinoma: NOS, cuniculatum carcinoma/Ackerman tumor - 4298030 Papillary squamous cell carcinoma - 4191609 Squamous cell carcinoma - 4103543 Squamous cell carcinoma: HPV-positive - 37204531 Squamous cell carcinoma: HPV-negative - 37204532

                                                                                                                      Control1..1
                                                                                                                      TypeCodeableConcept
                                                                                                                      Obligations
                                                                                                                        ObligationsActor
                                                                                                                        SHALL:handle
                                                                                                                        SHALL:handle
                                                                                                                        22. CancerEpisode.hnClassification.histologyAdenocarcinoma
                                                                                                                        Definition

                                                                                                                        Specifies the histological subgroup for adenocarcinomas

                                                                                                                        ShortHistology Adenocarcinoma
                                                                                                                        Comments

                                                                                                                        Intestinal-type (sinonasal) adenocarcinoma; NOS, non?intestinal-type (sinonasal), Endolymphatic sac low grade, Intestinal-type (salivary gland), cystoadenocarcinoma, mucinous, Ceruminous (only in ear); Nasopharyngeal papillary adenocarcinoma, thyroid like low grade nasopharingeal papillary adenocarcinoma; Adenoid cystic carcinoma; Adenoid cystic carcinoma: solid type (> 30% solid); Mucoepidermoid carcinoma; Polymorphous, Cribriform of minor salivary glands, Polymorphous (low grade), terminal duct carcinoma, lobular carcinoma; Acinic cell carcinoma;Clear cell carcinoma, hyalinising clear cell carcinoma; Basal cell adenocarcinoma, malignant dermal analog tumor;Salivary duct carcinoma, high grade ductal carcinoma;Salivary secretory adenocarcinoma (mammary analog, MASC); Secretory carcinoma; Myoepithelial carcinoma, malignant myoepithelioma; Carcinoma ex pleomorphic adenoma: NOS, Intracapsular, minimally invasive, largely invasive; Sebaceous adenocarcinoma, Sebaceous lymphadenocarcinoma; Carcinosarcoma; Oncocytic carcinoma, oxyphilic carcinoma, oncocytic adenocarcinoma, oncocytic malignant oncocytoma; Salivary gland intraductal carcinoma (cribriform low grade adenocarcinoma)
                                                                                                                        Intestinal-type (sinonasal) adenocarcinoma - CHECK WHICH SON NOS, non?intestinal-type (sinonasal) - FROM HERE?, Endolymphatic sac low grade, Intestinal-type (salivary gland) - 4312929, cystoadenocarcinoma - 4050978, mucinous - 4247921, Ceruminous (only in ear) - 4238334 Nasopharyngeal papillary adenocarcinoma - 605208, thyroid like low grade nasopharingeal papillary adenocarcinoma Adenoid cystic carcinoma - 4022895 Adenoid cystic carcinoma: solid type (> 30% solid) Mucoepidermoid carcinoma - 4253608 Polymorphous Cribriform of minor salivary glands - THERE IS NO MINOR BUT MAJOR SALIVARY GLANDS Polymorphous (low grade) - 4030121 terminal duct carcinoma - NOT SURE lobular carcinoma - 4232456 Acinic cell carcinoma - 4164740 Clear cell carcinoma - 4148292, hyalinising clear cell carcinoma Basal cell adenocarcinoma - 4146684 malignant dermal analog tumor - NOT SURE Salivary duct carcinoma - 4287334 high grade ductal carcinoma Salivary secretory adenocarcinoma (mammary analog, MASC) - 37116978 Secretory carcinoma - LOOKS LIKE NO MAPPING IN SNOMED Myoepithelial carcinoma, malignant myoepithelioma - 4029680 Carcinoma ex pleomorphic adenoma: NOS, Intracapsular, minimally invasive, largely invasive Sebaceous adenocarcinoma - 4182993 Sebaceous lymphadenocarcinoma - 37116976 Carcinosarcoma - 4271564 Oncocytic carcinoma oxyphilic carcinoma - 4212379 oncocytic adenocarcinoma oncocytic malignant oncocytoma Salivary gland intraductal carcinoma (cribriform low grade adenocarcinoma)

                                                                                                                        Control1..1
                                                                                                                        TypeCodeableConcept
                                                                                                                        Obligations
                                                                                                                          ObligationsActor
                                                                                                                          SHALL:handle
                                                                                                                          SHALL:handle
                                                                                                                          24. CancerEpisode.hnClassification.histologyNeuroendocrine
                                                                                                                          Definition

                                                                                                                          Specifies the histological subgroup for neuroendocrine cancers

                                                                                                                          ShortHistology Neuroendocrine
                                                                                                                          Comments

                                                                                                                          Small cell neuroendocrine�carcinoma (SmCC)?,Poorly differentiated neuroendocrine carcinoma, small cell (grade 3);Large cell neuroendocrine carcinoma (LCNEC)?, Poorly differentiated neuroendocrine carcinoma, large cell (grade 3);Well-differentiated neuroendocrine carcinoma, Middle ear carcinoid tumor;Moderately differentiated neuroendocrine carcinoma Small cell neuroendocrine�carcinoma (SmCC)? - 36714029 Poorly differentiated neuroendocrine carcinoma - 37018672 small cell (grade 3) Large cell neuroendocrine carcinoma (LCNEC)? - 4029971 Poorly differentiated neuroendocrine carcinoma, large cell (grade 3) Well-differentiated neuroendocrine carcinoma, Middle ear carcinoid tumor Moderately differentiated neuroendocrine carcinoma

                                                                                                                          Control1..1
                                                                                                                          TypeCodeableConcept
                                                                                                                          Obligations
                                                                                                                            ObligationsActor
                                                                                                                            SHALL:handle
                                                                                                                            SHALL:handle
                                                                                                                            26. CancerEpisode.hnClassification.histologyOdontogenicCarcinoma
                                                                                                                            Definition

                                                                                                                            Specifies the histological subgroup for odontogenic carcinomas

                                                                                                                            ShortHistology Odontogenic Carcinoma
                                                                                                                            Comments

                                                                                                                            Odontogenic carcinoma, NOS, Ameloblastic carcinoma (primary, secondary intraosseous, secondary peripheral), Primary intraosseous carcinoma, Intraosseous carcinoma developed on odontogenic cyst, sclerosing odontogenic carcinoma; Clear cell odontogenic carcinoma; Gosht cell odontogenic carcinoma Odontogenic carcinoma, NOS - 4098585 Ameloblastic carcinoma (primary, secondary intraosseous, secondary peripheral) - 37116638 Secondary dedifferentiated intraosseous ameloblastic carcinoma

                                                                                                                            • 37116980 Secondary dedifferentiated peripheral ameloblastic carcinoma - 37116979 Primary intraosseous carcinoma - 37117009 Intraosseous carcinoma developed on odontogenic cyst - 37116887 sclerosing odontogenic carcinoma Clear cell odontogenic carcinoma - 734032001 Gosht cell odontogenic carcinoma - 37312303
                                                                                                                            Control1..1
                                                                                                                            TypeCodeableConcept
                                                                                                                            Obligations
                                                                                                                              ObligationsActor
                                                                                                                              SHALL:handle
                                                                                                                              SHALL:handle
                                                                                                                              28. CancerEpisode.hnClassification.histologySNUC
                                                                                                                              Definition

                                                                                                                              Specifies the histological subgroup for sinonasl undifferentiated carcinomas

                                                                                                                              ShortHistology Sinonasal undifferentiated carcinoma
                                                                                                                              Comments

                                                                                                                              SMARCB1 (INI-1)-deficient Sinonasal undifferentiated Carcinoma;Sinonasal SMARCA4 deficient carcinoma;IDH2-mutated sinonasal undifferentiated neoplasm SMARCB1 (INI-1)-deficient Sinonasal undifferentiated Carcinoma Sinonasal SMARCA4 deficient carcinoma IDH2-mutated sinonasal undifferentiated neoplasm

                                                                                                                              Control1..1
                                                                                                                              TypeCodeableConcept
                                                                                                                              Obligations
                                                                                                                                ObligationsActor
                                                                                                                                SHALL:handle
                                                                                                                                SHALL:handle
                                                                                                                                30. CancerEpisode.sarcomaClassification
                                                                                                                                Definition

                                                                                                                                Sarcoma classification

                                                                                                                                ShortSarcoma classification
                                                                                                                                Control1..1
                                                                                                                                TypeBackboneElement
                                                                                                                                Obligations
                                                                                                                                  ObligationsActor
                                                                                                                                  SHALL:handle
                                                                                                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                                  32. CancerEpisode.sarcomaClassification.modifierExtension
                                                                                                                                  Definition

                                                                                                                                  May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                                                                                                                  Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                                                                                                                  ShortExtensions that cannot be ignored even if unrecognized
                                                                                                                                  Comments

                                                                                                                                  There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                                                                  Control0..*
                                                                                                                                  TypeExtension
                                                                                                                                  Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                                                                                                                  Summarytrue
                                                                                                                                  Requirements

                                                                                                                                  Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                                                                                                                  Alternate Namesextensions, user content, modifiers
                                                                                                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                                  ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                                                  34. CancerEpisode.sarcomaClassification.adipocyticTumours
                                                                                                                                  Definition

                                                                                                                                  Specifies the histological subgroup for adipocytic tumours

                                                                                                                                  ShortHistology subgroup Adipocytic tumours
                                                                                                                                  Comments

                                                                                                                                  Atypical lipomatous tumour/ Liposarcoma, well-differentiated, NOS Dedifferentiated liposarcoma Myxoid liposarcoma Pleomorphic liposarcoma Myxoid pleomorphic liposarcoma

                                                                                                                                  Liposarcoma, well differentiated - 4102790 Dedifferentiated liposarcoma - 4284833 Myxoid liposarcoma - 4101123 Pleomorphic liposarcoma - 4010104 Myxoid pleomorphic liposarcoma - 4300687

                                                                                                                                  Control1..1
                                                                                                                                  TypeCodeableConcept
                                                                                                                                  Obligations
                                                                                                                                    ObligationsActor
                                                                                                                                    SHALL:handle
                                                                                                                                    36. CancerEpisode.sarcomaClassification.fmtTumours
                                                                                                                                    Definition

                                                                                                                                    Histology subgroup Fibroblastic and myofibroblastic tumours

                                                                                                                                    ShortHistology subgroup Fibroblastic and myofibroblastic tumours
                                                                                                                                    Comments

                                                                                                                                    Palmar/plantar-type fibromatosis Desmoid-type fibromatosis Lipofibromatosis Giant cell fibroblastoma Dermatofibrosarcoma protuberans NOS Solitary fibrous tumour, benign; NOS; malignant Inflammatory myofibroblastic tumour Low-grade myofibroblastic sarcoma Superficial CD34-positive fibroblastic tumour Myxoinflammatory fibroblastic sarcoma Infantile fibrosarcoma Adult fibrosarcoma Myxofibrosarcoma Low-grade fibromyxoid sarcoma Sclerosing epithelioid fibrosarcoma

                                                                                                                                    Palmar/plantar-type fibromatosis - 45766452 Desmoid-type fibromatosis - 4264204 Lipofibromatosis - 45766468 Giant cell fibroblastoma - 4030132 Dermatofibrosarcoma protuberans - 4295283 Solitary fibrous tumor - 4030130 Solitary fibrous tumor, malignant - 4028562 Myofibroblastic tumour - 4021373 Low-grade myofibroblastic sarcoma - 45766454 Cellular fibroma - 4029679 Myxoinflammatory fibroblastic sarcoma - 45766450 Infantile fibrosarcoma - 4178132 Fibrosarcoma - 4202374 Myxofibrosarcoma - 45771359 Low-grade fibromyxoid sarcoma - 45771361 Sclerosing epithelioid fibrosarcoma - 45766456

                                                                                                                                    Control1..1
                                                                                                                                    TypeCodeableConcept
                                                                                                                                    Obligations
                                                                                                                                      ObligationsActor
                                                                                                                                      SHALL:handle
                                                                                                                                      38. CancerEpisode.sarcomaClassification.socalledFibrohistiocyticTumours
                                                                                                                                      Definition

                                                                                                                                      Histology subgroup So-called fibrohistiocytic tumours

                                                                                                                                      ShortHistology subgroup So-called fibrohistiocytic tumours
                                                                                                                                      Comments

                                                                                                                                      Plexiform fibrohistiocytic tumour Giant cell tumour of soft parts NOS Tenosynovial giant cell tumor

                                                                                                                                      Plexiform fibrohistiocytic tumour - 4029525 Giant cell tumour of soft parts - 4218898 Tenosynovial giant cell tumor - 4030140 Tenosynovial giant cell tumor, diffuse - 45766525 Malignant tenosynovial giant cell tumor - 4029655

                                                                                                                                      Control1..1
                                                                                                                                      TypeCodeableConcept
                                                                                                                                      Obligations
                                                                                                                                        ObligationsActor
                                                                                                                                        SHALL:handle
                                                                                                                                        40. CancerEpisode.sarcomaClassification.vascularTumours
                                                                                                                                        Definition

                                                                                                                                        Vascular tumours

                                                                                                                                        ShortVascular tumours
                                                                                                                                        Comments

                                                                                                                                        Epithelioid haemangioendothelioma NOS Angiosarcoma Kaposiform haemangioendothelioma ha anche la forma benigna 9161/0 Acquired tufted haemangioma. teniamo anche la fomra benigna? Retiform haemangioendothelioma Papillary intralymphatic angioendothelioma Composite haemangioendothelioma Pseudomyogenic (epithelioid sarcoma?like) haemangioendothelioma

                                                                                                                                        Epithelioid haemangioendothelioma - 4207381 Angiosarcoma - 3661612 Hemangioendothelioma - 4281384 Retiform haemangioendothelioma - 45766493 Endovascular papillary angioendothelioma - 4030138 Composite haemangioendothelioma - 45766494 Pseudomyogenic (epithelioid sarcoma-like) hemangioendothelioma - 45766492

                                                                                                                                        Control1..1
                                                                                                                                        TypeCodeableConcept
                                                                                                                                        Obligations
                                                                                                                                          ObligationsActor
                                                                                                                                          SHALL:handle
                                                                                                                                          42. CancerEpisode.sarcomaClassification.pericyticPerivascularTumours
                                                                                                                                          Definition

                                                                                                                                          Pericytic (perivascular) tumours

                                                                                                                                          ShortPericytic (perivascular) tumours
                                                                                                                                          Comments

                                                                                                                                          Glomus tumour NOS

                                                                                                                                          Glomus tumour - 40571984

                                                                                                                                          Control1..1
                                                                                                                                          TypeCodeableConcept
                                                                                                                                          Obligations
                                                                                                                                            ObligationsActor
                                                                                                                                            SHALL:handle
                                                                                                                                            44. CancerEpisode.sarcomaClassification.smoothMuscleTumours
                                                                                                                                            Definition

                                                                                                                                            Smooth muscle tumours

                                                                                                                                            ShortSmooth muscle tumours
                                                                                                                                            Comments

                                                                                                                                            Smooth muscle tumour of uncertain malignant potential Epithelioid smooth muscle tumor of uncertain malignant potential Myxoid smooth muscle tumour of uncertain mailgnant potential-Spindle smooth muscle tumor of uncertain malignant potential Metastasizing leiomyoma Leiomyosarcoma NOS Epithelioid leiomyosarcoma Myxoid leiomyosarcoma Metastasizing leiomyoma

                                                                                                                                            Smooth muscle tumour - 4327493 Epithelioid smooth muscle tumor of uncertain malignant potential - 607803 Myxoid smooth muscle tumour of uncertain mailgnant potential - 600675 Spindle smooth muscle tumor of uncertain malignant potential Metastasizing leiomyoma - 4029023 Leiomyosarcoma - 4201415 Epithelioid leiomyosarcoma - 4173148 Myxoid leiomyosarcoma - 4059632 Metastasizing leiomyoma - 4029023

                                                                                                                                            Control1..1
                                                                                                                                            TypeCodeableConcept
                                                                                                                                            Obligations
                                                                                                                                              ObligationsActor
                                                                                                                                              SHALL:handle
                                                                                                                                              46. CancerEpisode.sarcomaClassification.skeletalMuscleTumours
                                                                                                                                              Definition

                                                                                                                                              Skeletal muscle tumours

                                                                                                                                              ShortSkeletal muscle tumours
                                                                                                                                              Comments

                                                                                                                                              Embryonal rhabdomyosarcoma NOS Alveolar rhabdomyosarcoma Pleomorphic rhabdomyosarcoma NOS Spindle cell / sclerosing rhabdomyosarcoma Ectomesenchymoma

                                                                                                                                              Embryonal rhabdomyosarcoma - 4031038 Alveolar rhabdomyosarcoma - 4272931 Pleomorphic rhabdomyosarcoma - 4298312 Spindle cell rhabdomyosarcoma - 4029528 Rhabdomyosarcoma with ganglionic differentiation - 4029024

                                                                                                                                              Control1..1
                                                                                                                                              TypeCodeableConcept
                                                                                                                                              Obligations
                                                                                                                                                ObligationsActor
                                                                                                                                                SHALL:handle
                                                                                                                                                48. CancerEpisode.sarcomaClassification.chondroOsseousTumours
                                                                                                                                                Definition

                                                                                                                                                Chondro-osseous tumours

                                                                                                                                                ShortChondro-osseous tumours
                                                                                                                                                Comments

                                                                                                                                                Extraskeletal osteosarcoma

                                                                                                                                                Extraskeletal osteosarcoma - 4298240

                                                                                                                                                Control1..1
                                                                                                                                                TypeCodeableConcept
                                                                                                                                                Obligations
                                                                                                                                                  ObligationsActor
                                                                                                                                                  SHALL:handle
                                                                                                                                                  50. CancerEpisode.sarcomaClassification.peripheralNerveSheathTumours
                                                                                                                                                  Definition

                                                                                                                                                  Peripheral nerve sheath tumours

                                                                                                                                                  ShortPeripheral nerve sheath tumours
                                                                                                                                                  Comments

                                                                                                                                                  Malignant peripheral nerve sheath tumour NOS Malignant melanotic nerve sheath tumour Granular cell tumour NOS Granular cell tumour, malignant

                                                                                                                                                  Malignant peripheral nerve sheath tumour - 4062426 Melanotic malignant peripheral nerve sheath tumor - 4102399 Granular cell tumour - 4005360 Granular cell tumour, malignant - 4027842

                                                                                                                                                  Control1..1
                                                                                                                                                  TypeCodeableConcept
                                                                                                                                                  Obligations
                                                                                                                                                    ObligationsActor
                                                                                                                                                    SHALL:handle
                                                                                                                                                    52. CancerEpisode.sarcomaClassification.tumoursOfUncertainDifferentiation
                                                                                                                                                    Definition

                                                                                                                                                    Tumours of uncertain differentiation

                                                                                                                                                    ShortTumours of uncertain differentiation
                                                                                                                                                    Comments

                                                                                                                                                    Atypical fibroxanthoma Angiomatoid fibrous histiocytoma Pleomorphic hyalinizing angiectatic tumour Haemosiderotic fibrolipomatous tumour NTRK-rearranged spindle cell neoplasms Synovial sarcoma NOS Epithelioid sarcoma Alveolar soft part sarcoma Clear cell sarcoma NOS Extra-skeletal myxoid chondrosarcoma Desmoplastic small round cell tumour Extra-renal rhabdoid tumour NOS PEComas Intimal sarcoma Undifferentiated sarcoma Myoepithelioma Ossifying fibromyxoid tumour Phosphaturic mesenchymal tumour, malignant Aggressive angiomyxoma Angiomatoid fibrous histiocytoma NTRK-rearranged spindle cell neoplasm (emerging)

                                                                                                                                                        Atypical fibrous histiocytoma - 4096931
                                                                                                                                                    

                                                                                                                                                    Angiomatoid fibrous histiocytoma - 4029526 Pleomorphic hyalinizing angiectatic tumour - 45766448 Haemosiderotic fibrolipomatous tumour NTRK-rearranged spindle cell neoplasms - CUSTOM CODE Synovial sarcoma - 4268491 Epithelioid sarcoma - 4244886 Alveolar soft part sarcoma - 4339208 Clear cell sarcoma - 4155072 Myxoid chondrosarcoma - 4328092 Desmoplastic small round cell tumor - 4029522 Malignant rhabdoid tumor - 4307938 Perivascular epithelioid tumor, benign - 45771358 Perivascular epithelioid tumor, malignant - 45766447 Perivascular epithelioid cell tumor - 4304780 Intimal sarcoma - 45766495 Undifferentiated sarcoma - 4029021 Myoepithelioma - 4239519 Ossifying fibromyxoid tumour - 4028565 Phosphaturic mesenchymal tumour, malignant - 45766485 Aggressive angiomyxoma - 4239956 Angiomatoid fibrous histiocytoma - 4029526 NTRK-rearranged spindle cell neoplasm (emerging)

                                                                                                                                                    Control1..1
                                                                                                                                                    TypeCodeableConcept
                                                                                                                                                    Obligations
                                                                                                                                                      ObligationsActor
                                                                                                                                                      SHALL:handle
                                                                                                                                                      54. CancerEpisode.sarcomaClassification.undifSmallRCelSarcBonAndSofTis
                                                                                                                                                      Definition

                                                                                                                                                      Undifferentiated small round cell sarcomas of bone and soft tissue

                                                                                                                                                      ShortUndifferentiated small round cell sarcomas of bone and soft tissue
                                                                                                                                                      Comments

                                                                                                                                                      Ewing sarcoma Round cell sarcoma with�EWSR1?non-ETS fusions CIC-rearranged sarcoma Sarcoma with�BCOR�genetic alterations

                                                                                                                                                      Ewing sarcoma - 45766528 Round cell sarcoma with�EWSR1?non-ETS fusions CIC-rearranged sarcoma Sarcoma with�BCOR�genetic alterations

                                                                                                                                                      Control1..1
                                                                                                                                                      TypeCodeableConcept
                                                                                                                                                      Obligations
                                                                                                                                                        ObligationsActor
                                                                                                                                                        SHALL:handle
                                                                                                                                                        56. CancerEpisode.sarcomaClassification.estAndRelatedTumours
                                                                                                                                                        Definition

                                                                                                                                                        Endometrial stromal and related tumours

                                                                                                                                                        ShortEndometrial stromal and related tumours
                                                                                                                                                        Comments

                                                                                                                                                        Endometrial stromal sarcoma, high grade Endometrial stromal sarcoma, low grade

                                                                                                                                                        Endometrial stromal sarcoma, high grade - 4290926 Endometrial stromal sarcoma, low grade - 4028557

                                                                                                                                                        Control1..1
                                                                                                                                                        TypeCodeableConcept
                                                                                                                                                        Obligations
                                                                                                                                                          ObligationsActor
                                                                                                                                                          SHALL:handle
                                                                                                                                                          58. CancerEpisode.sarcomaClassification.miscellaniousMesenchimalTumors
                                                                                                                                                          Definition

                                                                                                                                                          Miscellanious mesenchimal tumors

                                                                                                                                                          ShortMiscellanious mesenchimal tumors
                                                                                                                                                          Comments

                                                                                                                                                          Uterine tumour resembling ovarian sex cord tumour Phyllodes tumour, benign Phyllodes tumour NOS Phyllodes tumour, borderline Phyllodes tumour, malignant Follicular dendritic cell sarcoma Histiocytic sarcoma Interdigitating dendritic cell sarcoma Langherans cell sarcoma Fibroblastic reticular cell tumour Biphenotypic sinonasal sarcoma

                                                                                                                                                          Uterine tumour resembling ovarian sex cord tumour - 45771357 Benign phyllodes tumor - 4040991 Borderline phyllodes tumor - 4323562 Phyllodes tumour, malignant - 4337106 Follicular dendritic cell sarcoma - 4028710 Histiocytic sarcoma - 4029172 Interdigitating dendritic cell sarcoma - 4028709 Langherans cell sarcoma - 4029173 Fibroblastic reticular cell tumour - 42872917 Biphenotypic sinonasal sarcoma - 37311513

                                                                                                                                                          Control1..1
                                                                                                                                                          TypeCodeableConcept
                                                                                                                                                          Obligations
                                                                                                                                                            ObligationsActor
                                                                                                                                                            SHALL:handle
                                                                                                                                                            60. CancerEpisode.sarcomaClassification.mixedEpithelialAndMesenchymalTumours
                                                                                                                                                            Definition

                                                                                                                                                            Mixed epithelial and mesenchymal tumours

                                                                                                                                                            ShortMixed epithelial and mesenchymal tumours
                                                                                                                                                            Comments

                                                                                                                                                            Adenosarcoma; please clarify if adenosarcoma with sarcomatous overgrowth

                                                                                                                                                            Adenosarcoma - 4135215

                                                                                                                                                            Control1..1
                                                                                                                                                            TypeCodeableConcept
                                                                                                                                                            Obligations
                                                                                                                                                              ObligationsActor
                                                                                                                                                              SHALL:handle
                                                                                                                                                              62. CancerEpisode.subsites
                                                                                                                                                              Definition

                                                                                                                                                              subsites

                                                                                                                                                              Shortsubsites
                                                                                                                                                              Control1..1
                                                                                                                                                              TypeBackboneElement
                                                                                                                                                              Obligations
                                                                                                                                                                ObligationsActor
                                                                                                                                                                SHALL:handle
                                                                                                                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                                                                64. CancerEpisode.subsites.modifierExtension
                                                                                                                                                                Definition

                                                                                                                                                                May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                                                                                                                                                Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                                                                                                                                                ShortExtensions that cannot be ignored even if unrecognized
                                                                                                                                                                Comments

                                                                                                                                                                There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                                                                                                Control0..*
                                                                                                                                                                TypeExtension
                                                                                                                                                                Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                                                                                                                                                Summarytrue
                                                                                                                                                                Requirements

                                                                                                                                                                Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                                                                                                                                                Alternate Namesextensions, user content, modifiers
                                                                                                                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                                                                ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                                                                                66. CancerEpisode.subsites.nasalCavityAndParanasalSinuses
                                                                                                                                                                Definition

                                                                                                                                                                Specifies the subsite for cancers occurred in nasal cavity and paranasal sinusess

                                                                                                                                                                ShortNasal cavity and paranasal sinuses subsite
                                                                                                                                                                Comments

                                                                                                                                                                AJCC 8th Edition Cancer Staging Manual

                                                                                                                                                                Nasal cavity;Maxillary sinus;Ethmoid sinus;Frontal sinus;Sphenoid sinus Nasal cavity - 4088327 Maxillary sinus - 4050631 Ethmoid sinus - 4182234 Frontal sinus - 4204534 Sphenoid sinus - 4097172

                                                                                                                                                                Control1..1
                                                                                                                                                                TypeCodeableConcept
                                                                                                                                                                Obligations
                                                                                                                                                                  ObligationsActor
                                                                                                                                                                  SHALL:handle
                                                                                                                                                                  68. CancerEpisode.subsites.nasopharynx
                                                                                                                                                                  Definition

                                                                                                                                                                  Specifies the subsite for cancers occurred in nasopharynx

                                                                                                                                                                  ShortNasopharynx subsite
                                                                                                                                                                  Comments

                                                                                                                                                                  AJCC 8th Edition Cancer Staging Manual

                                                                                                                                                                  Superior wall of nasopharynx;Posterior wall of nasopharynx;Lateral wall of nasopharynx;Anterior wall of nasopharynx Superior wall of nasopharynx - 4068978 Posterior wall of nasopharynx - 4146741 Lateral wall of nasopharynx - 4323979 Anterior wall of nasopharynx - 4220236

                                                                                                                                                                  Control1..1
                                                                                                                                                                  TypeCodeableConcept
                                                                                                                                                                  Obligations
                                                                                                                                                                    ObligationsActor
                                                                                                                                                                    SHALL:handle
                                                                                                                                                                    70. CancerEpisode.subsites.hypopharynx
                                                                                                                                                                    Definition

                                                                                                                                                                    Specifies the subsite for cancers occurred in hypopharynx

                                                                                                                                                                    ShortHypopharynx subsite
                                                                                                                                                                    Comments

                                                                                                                                                                    AJCC 8th Edition Cancer Staging Manual

                                                                                                                                                                    Postcricoid region; Hypopharyngeal aspect of aryepiglottic fold; Posterior wall of hypopharynx;Pyriform sinus

                                                                                                                                                                    Postcricoid region - 4147741 Hypopharyngeal aspect of aryepiglottic fold - 4262980 Posterior wall of hypopharynx - 4102600 Pyriform sinus - 4268741

                                                                                                                                                                    Control1..1
                                                                                                                                                                    TypeCodeableConcept
                                                                                                                                                                    Obligations
                                                                                                                                                                      ObligationsActor
                                                                                                                                                                      SHALL:handle
                                                                                                                                                                      72. CancerEpisode.subsites.oropharynx
                                                                                                                                                                      Definition

                                                                                                                                                                      Specifies the subsite for cancers occurred in oropharynx

                                                                                                                                                                      ShortOropharynx subsite
                                                                                                                                                                      Comments

                                                                                                                                                                      https://link.springer.com/book/9783319406176

                                                                                                                                                                      Base of tongue, NOS; Soft palate NOS (excludes Nasopharyngcal surface C11.3); Uvula; Tonsillar fossa; Lingual tonsil; Tonsillar pillar; Vallecula; Anterior surface of epiglottis; Lateral wall oropharynx; Posterior wall oropharynx; Branchial cleft (site of neoplosm);

                                                                                                                                                                      Base of tongue, NOS - 4169910 Soft palate NOS (excludes Nasopharyngcal surface C11.3) - 4177005 Uvula - 4095284 Tonsillar fossa - 4138234 Lingual tonsil - 4068841 Tonsillar pillar - 4065073 Vallecula - 4173123 Anterior surface of epiglottis - 4283238 Lateral wall oropharynx - 4078066 Posterior wall oropharynx - 4045435 Branchial cleft (site of neoplosm) - 4235649

                                                                                                                                                                      Control1..1
                                                                                                                                                                      TypeCodeableConcept
                                                                                                                                                                      Obligations
                                                                                                                                                                        ObligationsActor
                                                                                                                                                                        SHALL:handle
                                                                                                                                                                        74. CancerEpisode.subsites.larynx
                                                                                                                                                                        Definition

                                                                                                                                                                        Specifies the subsite for cancers occurred in larynx

                                                                                                                                                                        ShortLarynx subsite
                                                                                                                                                                        Comments

                                                                                                                                                                        AJCC 8th Edition Cancer Staging Manual Glottis;Supraglottis;Subglottis;Laryngeal cartilage

                                                                                                                                                                        Glottis - 4047227 Supraglottis - 4001049 Subglottis - 4002724 Laryngeal cartilage - 4279711

                                                                                                                                                                        Control1..1
                                                                                                                                                                        TypeCodeableConcept
                                                                                                                                                                        Obligations
                                                                                                                                                                          ObligationsActor
                                                                                                                                                                          SHALL:handle
                                                                                                                                                                          76. CancerEpisode.subsites.oralCavity
                                                                                                                                                                          Definition

                                                                                                                                                                          Specifies the subsite for cancers occurred in oral cavity

                                                                                                                                                                          ShortOral cavity subsite
                                                                                                                                                                          Comments

                                                                                                                                                                          AJCC 8th Edition Cancer Staging Manual

                                                                                                                                                                          Dorsal surface tongue, NOS; Border of tongue; Ventral surface of tongue NOS; Anterior 2/3 of tongue NOS; Upper gum; Lower gum; Anterior floor of mouth; Lateral floor of mouth; Overlapping lesion of floor of mouth; Hard palate; Cheek mucosa; Vestibule of mouth; Retromolar area; Overlapping lesion of other and unspecified parts of mouth; Dorsal surface tongue, NOS - 36769609 Border of tongue - 4077986 Ventral surface of tongue - 4172794 Anterior 2/3 of tongue NOS Upper gum - 4047029 Lower gum - 4210919 Anterior floor of mouth - 4181419 Lateral floor of mouth - 4103066 Overlapping lesion of floor of mouth - 44498040 Hard palate - 4234542 Cheek mucosa - 4057160 Vestibule of mouth - 4144069 Retromolar area - 36769865 Overlapping lesion of other and unspecified parts of mouth -

                                                                                                                                                                          Control1..1
                                                                                                                                                                          TypeCodeableConcept
                                                                                                                                                                          Obligations
                                                                                                                                                                            ObligationsActor
                                                                                                                                                                            SHALL:handle
                                                                                                                                                                            78. CancerEpisode.subsites.lip
                                                                                                                                                                            Definition

                                                                                                                                                                            Specifies the subsite for cancers occurred in lip

                                                                                                                                                                            ShortLip subsite
                                                                                                                                                                            Comments

                                                                                                                                                                            AJCC 8th Edition Cancer Staging Manual

                                                                                                                                                                            External lower lip;External upper lip;External lip, NOS;Mucosa of upper lip;Mucosa of lower lip;Mucosa of lip, NOS;Commissure of lip External lower lip - 4027546 External upper lip - 4134589 External lip, NOS - 4027545 Mucosa of upper lip - 36769700 Mucosa of lower lip - 36768548 Mucosa of lip, NOS - 4245168 Commissure of lip - 4307358

                                                                                                                                                                            Control1..1
                                                                                                                                                                            TypeCodeableConcept
                                                                                                                                                                            Obligations
                                                                                                                                                                              ObligationsActor
                                                                                                                                                                              SHALL:handle
                                                                                                                                                                              80. CancerEpisode.subsites.upperAndLowerLimbs
                                                                                                                                                                              Definition

                                                                                                                                                                              Specifies the subsite for cancers occurred in

                                                                                                                                                                              ShortUpper and Lower limbs subsite
                                                                                                                                                                              Comments

                                                                                                                                                                              Hand Wrist Forearm Elbow/Antecubital fossa Upper arm Foot Ankle Leg Knee/popliteal fossa Upper leg Deltoid Supraclavicular Periscapular Trapezius Groin Buttock Pectoral Axilla

                                                                                                                                                                              Hand structure - 4310976 Wrist region structure - 4220073 Forearm structure - 4032953 Elbow region structure - 4027910 Antecubital fossa (surface region) - 4348994 Upper arm structure - 4165266 Foot structure- 4211098 Ankle region structure - 4142359 Lower leg structure - 4107527 Knee region structure - 4217806 popliteal fossa structure - 4138531 Upper leg - 4090445 Deltoid - 4291935 Supraclavicular - 4088464 Periscapular region - 42605854 Trapezius - 4136969 Groin - 4109459 Buttock - 4263335 Pectoral - 4096078 Axilla - 4157836

                                                                                                                                                                              Control1..1
                                                                                                                                                                              TypeCodeableConcept
                                                                                                                                                                              Obligations
                                                                                                                                                                                ObligationsActor
                                                                                                                                                                                SHALL:handle
                                                                                                                                                                                82. CancerEpisode.subsites.trunkWallSubsite
                                                                                                                                                                                Definition

                                                                                                                                                                                Specifies the subsite for cancers occurred in

                                                                                                                                                                                ShortTrunk wall subsite
                                                                                                                                                                                Comments

                                                                                                                                                                                Thoracic Wall Abdominal Wall Paravertebral ? thoracolumbar Paravertebral ? cervical

                                                                                                                                                                                Joint structure of thoracic wall - 4088614 Anterior abdominal wall structure - 4244412 Posterior abdominal wall structure - 4330865 Paravertebral ? thoracolumbar - Paravertebral ? cervical

                                                                                                                                                                                Control1..1
                                                                                                                                                                                TypeCodeableConcept
                                                                                                                                                                                Obligations
                                                                                                                                                                                  ObligationsActor
                                                                                                                                                                                  SHALL:handle
                                                                                                                                                                                  84. CancerEpisode.subsites.intraAbdominalSubsite
                                                                                                                                                                                  Definition

                                                                                                                                                                                  Specifies the subsite for cancers occurred in

                                                                                                                                                                                  ShortIntra abdominal subsite
                                                                                                                                                                                  Comments

                                                                                                                                                                                  Retroperitoneum Vessels (please select: inferior vena cava, aorta, iliac vessels, renal vessels, gonadal vessels, mesenteric vessels, others) Pelvis Esophagus Stomach Duodenum Jejunum/Ileus Colon Rectum Mesentery

                                                                                                                                                                                  Retroperitoneal compartment structure - 4220536 Vessels (please select: inferior vena cava, aorta, iliac vessels, renal vessels, gonadal vessels, mesenteric vessels, others) Inferior vena cava structure - 4271699 Iliac vessel - 4193451 Structure of renal artery - 4154880 Gonadal artery - 4157844 Structure of mesenteric artery - 4314264 Other vessels - WILDCARD* Renal pelvis structure - 4094242 Major pelvis structure - 4229753 Region of esophagus - 4075991 Stomach - 4288283 Duodenal structure - 4302112 Jejunal structure - 4065077 Stricture of ileum - 4316356 Colon structure - 4215634 Rectum structure - 4144541 Mesentery - 4233095

                                                                                                                                                                                  Control1..1
                                                                                                                                                                                  TypeCodeableConcept
                                                                                                                                                                                  Obligations
                                                                                                                                                                                    ObligationsActor
                                                                                                                                                                                    SHALL:handle
                                                                                                                                                                                    86. CancerEpisode.subsites.intraThoracicSubsite
                                                                                                                                                                                    Definition

                                                                                                                                                                                    Specifies the subsite for cancers occurred in

                                                                                                                                                                                    ShortIntra thoracic subsite
                                                                                                                                                                                    Comments

                                                                                                                                                                                    Lung Heart Pleura Mediastinum Great vessels (please select: superior vena cava, aorta, pulmonary vessels, subclavian vessels, others)

                                                                                                                                                                                    Lung structure - 4213162 Heart structure - 4217142 Pleura structure - 4150673 Region of mediastinum - 4088610 Great vessels (please select: superior vena cava, aorta, pulmonary vessels, subclavian vessels, others) Superior vena cava structure - 4167648 Aorta part - 4001033 Stricture of pulmonary vessel - 4035327 Structure of subclavian artery - 4272388 Other - WILDCARD

                                                                                                                                                                                    Control1..1
                                                                                                                                                                                    TypeCodeableConcept
                                                                                                                                                                                    Obligations
                                                                                                                                                                                      ObligationsActor
                                                                                                                                                                                      SHALL:handle
                                                                                                                                                                                      88. CancerEpisode.subsites.genitoUrinarySubsite
                                                                                                                                                                                      Definition

                                                                                                                                                                                      Specifies the subsite for cancers occurred in

                                                                                                                                                                                      ShortGenito urinary subsite
                                                                                                                                                                                      Comments

                                                                                                                                                                                      Adrenal glands Kidney Urether Bladder Prostate Seminal Vescicle Spermatic Cord Testis Penis Utero Ovary Fallopian tube Vagina Vulva

                                                                                                                                                                                      Bilateral adrenal glands - 4047078 Kidney structure - 4271678 Region of ureter - 4078617 Urinary bladder structure - 4232481 Structure of lobe of prostate - 4034365 Seminal Vescicle structure - 4277442 Spermatic Cord structure - 4172591 Testis structure - 4238088 Penile structure - 4077311 Uterine structure - 4149192 Ovarian structure - 4049448 Fallopian tube structure - 4151444 Vaginal structure - 4296022 Vulval structure - 4166066

                                                                                                                                                                                      Control1..1
                                                                                                                                                                                      TypeCodeableConcept
                                                                                                                                                                                      Obligations
                                                                                                                                                                                        ObligationsActor
                                                                                                                                                                                        SHALL:handle
                                                                                                                                                                                        90. CancerEpisode.subsites.headAndNeckSubsite
                                                                                                                                                                                        Definition

                                                                                                                                                                                        Specifies the subsite for cancers occurred in

                                                                                                                                                                                        ShortHead and Neck subsite
                                                                                                                                                                                        Comments

                                                                                                                                                                                        Head and neck Face and/or neck structure - 4122633

                                                                                                                                                                                        Control1..1
                                                                                                                                                                                        TypeCodeableConcept
                                                                                                                                                                                        Obligations
                                                                                                                                                                                          ObligationsActor
                                                                                                                                                                                          SHALL:handle
                                                                                                                                                                                          92. CancerEpisode.subsites.breast
                                                                                                                                                                                          Definition

                                                                                                                                                                                          Specifies the subsite for cancers occurred in

                                                                                                                                                                                          ShortBreast subsite
                                                                                                                                                                                          Comments

                                                                                                                                                                                          Breast Breast structure - 4298444

                                                                                                                                                                                          Control1..1
                                                                                                                                                                                          TypeCodeableConcept
                                                                                                                                                                                          Obligations
                                                                                                                                                                                            ObligationsActor
                                                                                                                                                                                            SHALL:handle
                                                                                                                                                                                            94. CancerEpisode.subsites.others
                                                                                                                                                                                            Definition

                                                                                                                                                                                            Specifies the subsite for cancers occurred in

                                                                                                                                                                                            ShortOther subsite
                                                                                                                                                                                            Control1..1
                                                                                                                                                                                            TypeCodeableConcept
                                                                                                                                                                                            Obligations
                                                                                                                                                                                              ObligationsActor
                                                                                                                                                                                              SHALL:handle
                                                                                                                                                                                              96. CancerEpisode.tumorSize
                                                                                                                                                                                              Definition

                                                                                                                                                                                              (the longest diameter; longest dimension between pre operatory imaging and pathological specimen) cm

                                                                                                                                                                                              ShortTumor Size
                                                                                                                                                                                              Control1..1
                                                                                                                                                                                              TypeQuantity
                                                                                                                                                                                              Obligations
                                                                                                                                                                                                ObligationsActor
                                                                                                                                                                                                SHALL:handle
                                                                                                                                                                                                98. CancerEpisode.depth
                                                                                                                                                                                                Definition

                                                                                                                                                                                                (for upper and lower limbs and superficial trunk) superficial (superficial tumour is located exclusively above the investing fascia without invasion of the fascia), deep (deep tumour is located beneath or invade the investing fascia). All the others are deep by definition

                                                                                                                                                                                                ShortDepth
                                                                                                                                                                                                Control1..1
                                                                                                                                                                                                TypeCodeableConcept
                                                                                                                                                                                                Obligations
                                                                                                                                                                                                  ObligationsActor
                                                                                                                                                                                                  SHALL:handle
                                                                                                                                                                                                  100. CancerEpisode.biopsyMitoticCount
                                                                                                                                                                                                  Definition

                                                                                                                                                                                                  (Number/10HPF/1mm2, 50HPF/5mm2)

                                                                                                                                                                                                  ShortBiopsy Mitotic count
                                                                                                                                                                                                  Control1..1
                                                                                                                                                                                                  TypeQuantity
                                                                                                                                                                                                  Obligations
                                                                                                                                                                                                    ObligationsActor
                                                                                                                                                                                                    SHALL:handle
                                                                                                                                                                                                    102. CancerEpisode.plasmaticEbvDnaAtBaseline
                                                                                                                                                                                                    Definition

                                                                                                                                                                                                    Describes the result of EBV DNA plasma testing before treatment in NPC type II and III (WHO)

                                                                                                                                                                                                    ShortPlasmatic EBV DNA at baseline
                                                                                                                                                                                                    Comments

                                                                                                                                                                                                    Positive; Negative; not tested; Positive - 9191 Negative - 9189 not tested - 45878602

                                                                                                                                                                                                    Control0..1
                                                                                                                                                                                                    TypeCodeableConcept
                                                                                                                                                                                                    Obligations
                                                                                                                                                                                                      ObligationsActor
                                                                                                                                                                                                      SHALL:handle
                                                                                                                                                                                                      104. CancerEpisode.hpvStatus
                                                                                                                                                                                                      Definition

                                                                                                                                                                                                      Describes the result of HPV tumor testing in oral carcinoma

                                                                                                                                                                                                      ShortHPV status
                                                                                                                                                                                                      Comments

                                                                                                                                                                                                      Positive; Negative; Not tested; Positive - 9191 Negative - 9189 not tested - 45878602

                                                                                                                                                                                                      Control0..1
                                                                                                                                                                                                      TypeCodeableConcept
                                                                                                                                                                                                      Obligations
                                                                                                                                                                                                        ObligationsActor
                                                                                                                                                                                                        SHALL:handle
                                                                                                                                                                                                        106. CancerEpisode.crpCReactiveProteinTested
                                                                                                                                                                                                        Definition

                                                                                                                                                                                                        Describes the result of C reactive protein testing

                                                                                                                                                                                                        ShortCRP - C reactive protein tested
                                                                                                                                                                                                        Comments

                                                                                                                                                                                                        Positive; Negative; Not tested; Positive - 9191 Negative - 9189 not tested - 45878602

                                                                                                                                                                                                        Control0..1
                                                                                                                                                                                                        TypeCodeableConcept
                                                                                                                                                                                                        Obligations
                                                                                                                                                                                                          ObligationsActor
                                                                                                                                                                                                          SHALL:handle

                                                                                                                                                                                                          Guidance on how to interpret the contents of this table can be found here

                                                                                                                                                                                                          0. CancerEpisode
                                                                                                                                                                                                          Definition

                                                                                                                                                                                                          Cancer Episode Maturity Level: 0 Draft

                                                                                                                                                                                                          ShortCancer Episode
                                                                                                                                                                                                          Control0..*
                                                                                                                                                                                                          Is Modifierfalse
                                                                                                                                                                                                          Logical ModelInstances of this logical model are not marked to be the target of a Reference
                                                                                                                                                                                                          2. CancerEpisode.patient
                                                                                                                                                                                                          Definition

                                                                                                                                                                                                          Patient element containing the data regarding the patient followed by the hospital

                                                                                                                                                                                                          ShortPatient
                                                                                                                                                                                                          Control1..1
                                                                                                                                                                                                          Typehttp://hl7.eu/fhir/ig/idea4rc/StructureDefinition/Subject
                                                                                                                                                                                                          Obligations
                                                                                                                                                                                                            ObligationsActor
                                                                                                                                                                                                            SHALL:handle
                                                                                                                                                                                                            SHALL:handle
                                                                                                                                                                                                            4. CancerEpisode.dateOfDiagnosis
                                                                                                                                                                                                            Definition

                                                                                                                                                                                                            Date of the procedure from which the specimen was obtained that allowed the histological diagnosis.

                                                                                                                                                                                                            ShortDate of diagnosis (biopsy or surgical piece)
                                                                                                                                                                                                            Control1..1
                                                                                                                                                                                                            Typedate
                                                                                                                                                                                                            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                                                                                                                            Obligations
                                                                                                                                                                                                              ObligationsActor
                                                                                                                                                                                                              SHALL:handle
                                                                                                                                                                                                              SHALL:handle
                                                                                                                                                                                                              6. CancerEpisode.typeOfBiopsy
                                                                                                                                                                                                              Definition

                                                                                                                                                                                                              Type of biopsy performed

                                                                                                                                                                                                              ShortType of biopsy
                                                                                                                                                                                                              Comments

                                                                                                                                                                                                              FNA core-trcut incisional excisional unplanned excision

                                                                                                                                                                                                              Fine needle biopsy - 4171863 Core needle biopsy - 4321878 Incisional biopsy - 4321986 Excisional biopsy - 4228202 Excision - 4279903

                                                                                                                                                                                                              Control1..1
                                                                                                                                                                                                              TypeCodeableConcept
                                                                                                                                                                                                              Obligations
                                                                                                                                                                                                                ObligationsActor
                                                                                                                                                                                                                SHALL:handle
                                                                                                                                                                                                                8. CancerEpisode.biopsyDoneBy
                                                                                                                                                                                                                Definition

                                                                                                                                                                                                                Describes the institution where diagnostic procedure was performed

                                                                                                                                                                                                                ShortBiopsy done by
                                                                                                                                                                                                                Control1..1
                                                                                                                                                                                                                Typestring
                                                                                                                                                                                                                Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                                                                                                                                Obligations
                                                                                                                                                                                                                  ObligationsActor
                                                                                                                                                                                                                  SHALL:handle
                                                                                                                                                                                                                  SHALL:handle
                                                                                                                                                                                                                  10. CancerEpisode.ageAtDiagnosis
                                                                                                                                                                                                                  Definition

                                                                                                                                                                                                                  Age of the patient at the time of the diagnosis.

                                                                                                                                                                                                                  ShortAge at diagnosis
                                                                                                                                                                                                                  Control1..1
                                                                                                                                                                                                                  Typeinteger
                                                                                                                                                                                                                  Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                                                                                                                                  Obligations
                                                                                                                                                                                                                    ObligationsActor
                                                                                                                                                                                                                    SHALL:handle
                                                                                                                                                                                                                    SHALL:handle
                                                                                                                                                                                                                    12. CancerEpisode.radiotherapyInducedSarcoma
                                                                                                                                                                                                                    Definition

                                                                                                                                                                                                                    radiotherapy induced if the new tumour is in the field or marginal the anatomical area that received high radiation dose; please specify the interval time from the radiotherapy treatment

                                                                                                                                                                                                                    ShortRadiotherapy induced sarcoma
                                                                                                                                                                                                                    Comments

                                                                                                                                                                                                                    Radiation therapy induced change Radiation therapy induced change - 37117814

                                                                                                                                                                                                                    Control1..1
                                                                                                                                                                                                                    Typeboolean
                                                                                                                                                                                                                    Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                                                                                                                                    Obligations
                                                                                                                                                                                                                      ObligationsActor
                                                                                                                                                                                                                      SHALL:handle
                                                                                                                                                                                                                      14. CancerEpisode.grading
                                                                                                                                                                                                                      Definition

                                                                                                                                                                                                                      Grading of the cancer

                                                                                                                                                                                                                      ShortGrading
                                                                                                                                                                                                                      Comments

                                                                                                                                                                                                                      1 2 3 high low Grade-1 - 1634371 Grade-2 - 1634752 Grade-3 - 1633749 Grade-H - 1635587 Grade-L - 1634085

                                                                                                                                                                                                                      Control0..1
                                                                                                                                                                                                                      TypeCodeableConcept
                                                                                                                                                                                                                      Obligations
                                                                                                                                                                                                                        ObligationsActor
                                                                                                                                                                                                                        SHALL:handle
                                                                                                                                                                                                                        SHALL:handle
                                                                                                                                                                                                                        16. CancerEpisode.hnClassification
                                                                                                                                                                                                                        Definition

                                                                                                                                                                                                                        Classification for Head and Neck tumors

                                                                                                                                                                                                                        ShortClassification for Head and Neck tumors
                                                                                                                                                                                                                        Comments

                                                                                                                                                                                                                        Added to the model for grouping elements

                                                                                                                                                                                                                        Control1..1
                                                                                                                                                                                                                        TypeBackboneElement
                                                                                                                                                                                                                        Obligations
                                                                                                                                                                                                                          ObligationsActor
                                                                                                                                                                                                                          SHALL:handle
                                                                                                                                                                                                                          SHALL:handle
                                                                                                                                                                                                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                                                                                                                          18. CancerEpisode.hnClassification.id
                                                                                                                                                                                                                          Definition

                                                                                                                                                                                                                          Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                                                                                                                                                                          ShortUnique id for inter-element referencing
                                                                                                                                                                                                                          Control0..1
                                                                                                                                                                                                                          Typestring
                                                                                                                                                                                                                          Is Modifierfalse
                                                                                                                                                                                                                          XML FormatIn the XML format, this property is represented as an attribute.
                                                                                                                                                                                                                          Summaryfalse
                                                                                                                                                                                                                          20. CancerEpisode.hnClassification.extension
                                                                                                                                                                                                                          Definition

                                                                                                                                                                                                                          May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                                                                                                                                                                                                          ShortAdditional content defined by implementations
                                                                                                                                                                                                                          Comments

                                                                                                                                                                                                                          There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                                                                                                                                                          Control0..*
                                                                                                                                                                                                                          TypeExtension
                                                                                                                                                                                                                          Is Modifierfalse
                                                                                                                                                                                                                          Summaryfalse
                                                                                                                                                                                                                          Alternate Namesextensions, user content
                                                                                                                                                                                                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                                                                                                                          ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                                                                                                                                          SlicingThis element introduces a set of slices on CancerEpisode.hnClassification.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                                                                                                                                                                                          • value @ url
                                                                                                                                                                                                                          • 22. CancerEpisode.hnClassification.modifierExtension
                                                                                                                                                                                                                            Definition

                                                                                                                                                                                                                            May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                                                                                                                                                                                                            Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                                                                                                                                                                                                            ShortExtensions that cannot be ignored even if unrecognized
                                                                                                                                                                                                                            Comments

                                                                                                                                                                                                                            There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                                                                                                                                                            Control0..*
                                                                                                                                                                                                                            TypeExtension
                                                                                                                                                                                                                            Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                                                                                                                                                                                                            Summarytrue
                                                                                                                                                                                                                            Requirements

                                                                                                                                                                                                                            Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                                                                                                                                                                                                            Alternate Namesextensions, user content, modifiers
                                                                                                                                                                                                                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                                                                                                                            ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                                                                                                                                            24. CancerEpisode.hnClassification.histologySquamous
                                                                                                                                                                                                                            Definition

                                                                                                                                                                                                                            Specifies the histological subgroup for squamous cancers

                                                                                                                                                                                                                            ShortHistology Squamous
                                                                                                                                                                                                                            Comments

                                                                                                                                                                                                                            Keratinizing squamous cell carcinoma, epidermoid carcinoma; Non-keratinizing squamous cell carcinoma; Non-keratinizing squamous cell carcinoma: SMARCB1 (INI-1)-deficient Sinonasal Carcinoma ;Non-keratinizing squamous cell carcinoma: Transitional (cylindrical cell, Schneiderian) carcinoma ;Spindle cell (sarcomatoid) squamous cell carcinoma;Spindle cell (sarcomatoid) squamous cell carcinoma: SMARCB1 (INI-1)-deficient Sinonasal Carcinoma ;Lymphoepithelial carcinoma, lymphoepithelioma like carcinoma;Basaloid squamous cell carcinoma;Squamous cell carcinoma: conventional, NOS, clear cell, microinvasive, adenoid, acantholytic, pseudoglandular, giant cell ;Verrucous squamous cell carcinoma: NOS, cuniculatum carcinoma/Ackerman tumor; Papillary squamous cell carcinoma; Squamous cell carcinoma; Squamous cell carcinoma: HPV-positive; Squamous cell carcinoma: HPV-negative
                                                                                                                                                                                                                            Keratinizing squamous cell carcinoma, epidermoid carcinoma - 4078953 Non-keratinizing squamous cell carcinoma - 4147603 Non-keratinizing squamous cell carcinoma: SMARCB1 (INI-1)-deficient Sinonasal Carcinoma - (This should be a modifier? not clear) Non-keratinizing squamous cell carcinoma: Transitional (cylindrical cell, Schneiderian) carcinoma - 4206785 Spindle cell (sarcomatoid) squamous cell carcinoma - 4277415 Spindle cell (sarcomatoid) squamous cell carcinoma: SMARCB1 (INI-1)-deficient Sinonasal Carcinoma - (This should be a modifier? not clear) Lymphoepithelial carcinoma, lymphoepithelioma like carcinoma - 4247661 Basaloid squamous cell carcinoma - 4029973 Squamous cell carcinoma: conventional, NOS, clear cell, microinvasive, adenoid, acantholytic, pseudoglandular, giant cell Verrucous squamous cell carcinoma: NOS, cuniculatum carcinoma/Ackerman tumor - 4298030 Papillary squamous cell carcinoma - 4191609 Squamous cell carcinoma - 4103543 Squamous cell carcinoma: HPV-positive - 37204531 Squamous cell carcinoma: HPV-negative - 37204532

                                                                                                                                                                                                                            Control1..1
                                                                                                                                                                                                                            TypeCodeableConcept
                                                                                                                                                                                                                            Obligations
                                                                                                                                                                                                                              ObligationsActor
                                                                                                                                                                                                                              SHALL:handle
                                                                                                                                                                                                                              SHALL:handle
                                                                                                                                                                                                                              26. CancerEpisode.hnClassification.histologyAdenocarcinoma
                                                                                                                                                                                                                              Definition

                                                                                                                                                                                                                              Specifies the histological subgroup for adenocarcinomas

                                                                                                                                                                                                                              ShortHistology Adenocarcinoma
                                                                                                                                                                                                                              Comments

                                                                                                                                                                                                                              Intestinal-type (sinonasal) adenocarcinoma; NOS, non?intestinal-type (sinonasal), Endolymphatic sac low grade, Intestinal-type (salivary gland), cystoadenocarcinoma, mucinous, Ceruminous (only in ear); Nasopharyngeal papillary adenocarcinoma, thyroid like low grade nasopharingeal papillary adenocarcinoma; Adenoid cystic carcinoma; Adenoid cystic carcinoma: solid type (> 30% solid); Mucoepidermoid carcinoma; Polymorphous, Cribriform of minor salivary glands, Polymorphous (low grade), terminal duct carcinoma, lobular carcinoma; Acinic cell carcinoma;Clear cell carcinoma, hyalinising clear cell carcinoma; Basal cell adenocarcinoma, malignant dermal analog tumor;Salivary duct carcinoma, high grade ductal carcinoma;Salivary secretory adenocarcinoma (mammary analog, MASC); Secretory carcinoma; Myoepithelial carcinoma, malignant myoepithelioma; Carcinoma ex pleomorphic adenoma: NOS, Intracapsular, minimally invasive, largely invasive; Sebaceous adenocarcinoma, Sebaceous lymphadenocarcinoma; Carcinosarcoma; Oncocytic carcinoma, oxyphilic carcinoma, oncocytic adenocarcinoma, oncocytic malignant oncocytoma; Salivary gland intraductal carcinoma (cribriform low grade adenocarcinoma)
                                                                                                                                                                                                                              Intestinal-type (sinonasal) adenocarcinoma - CHECK WHICH SON NOS, non?intestinal-type (sinonasal) - FROM HERE?, Endolymphatic sac low grade, Intestinal-type (salivary gland) - 4312929, cystoadenocarcinoma - 4050978, mucinous - 4247921, Ceruminous (only in ear) - 4238334 Nasopharyngeal papillary adenocarcinoma - 605208, thyroid like low grade nasopharingeal papillary adenocarcinoma Adenoid cystic carcinoma - 4022895 Adenoid cystic carcinoma: solid type (> 30% solid) Mucoepidermoid carcinoma - 4253608 Polymorphous Cribriform of minor salivary glands - THERE IS NO MINOR BUT MAJOR SALIVARY GLANDS Polymorphous (low grade) - 4030121 terminal duct carcinoma - NOT SURE lobular carcinoma - 4232456 Acinic cell carcinoma - 4164740 Clear cell carcinoma - 4148292, hyalinising clear cell carcinoma Basal cell adenocarcinoma - 4146684 malignant dermal analog tumor - NOT SURE Salivary duct carcinoma - 4287334 high grade ductal carcinoma Salivary secretory adenocarcinoma (mammary analog, MASC) - 37116978 Secretory carcinoma - LOOKS LIKE NO MAPPING IN SNOMED Myoepithelial carcinoma, malignant myoepithelioma - 4029680 Carcinoma ex pleomorphic adenoma: NOS, Intracapsular, minimally invasive, largely invasive Sebaceous adenocarcinoma - 4182993 Sebaceous lymphadenocarcinoma - 37116976 Carcinosarcoma - 4271564 Oncocytic carcinoma oxyphilic carcinoma - 4212379 oncocytic adenocarcinoma oncocytic malignant oncocytoma Salivary gland intraductal carcinoma (cribriform low grade adenocarcinoma)

                                                                                                                                                                                                                              Control1..1
                                                                                                                                                                                                                              TypeCodeableConcept
                                                                                                                                                                                                                              Obligations
                                                                                                                                                                                                                                ObligationsActor
                                                                                                                                                                                                                                SHALL:handle
                                                                                                                                                                                                                                SHALL:handle
                                                                                                                                                                                                                                28. CancerEpisode.hnClassification.histologyNeuroendocrine
                                                                                                                                                                                                                                Definition

                                                                                                                                                                                                                                Specifies the histological subgroup for neuroendocrine cancers

                                                                                                                                                                                                                                ShortHistology Neuroendocrine
                                                                                                                                                                                                                                Comments

                                                                                                                                                                                                                                Small cell neuroendocrine�carcinoma (SmCC)?,Poorly differentiated neuroendocrine carcinoma, small cell (grade 3);Large cell neuroendocrine carcinoma (LCNEC)?, Poorly differentiated neuroendocrine carcinoma, large cell (grade 3);Well-differentiated neuroendocrine carcinoma, Middle ear carcinoid tumor;Moderately differentiated neuroendocrine carcinoma Small cell neuroendocrine�carcinoma (SmCC)? - 36714029 Poorly differentiated neuroendocrine carcinoma - 37018672 small cell (grade 3) Large cell neuroendocrine carcinoma (LCNEC)? - 4029971 Poorly differentiated neuroendocrine carcinoma, large cell (grade 3) Well-differentiated neuroendocrine carcinoma, Middle ear carcinoid tumor Moderately differentiated neuroendocrine carcinoma

                                                                                                                                                                                                                                Control1..1
                                                                                                                                                                                                                                TypeCodeableConcept
                                                                                                                                                                                                                                Obligations
                                                                                                                                                                                                                                  ObligationsActor
                                                                                                                                                                                                                                  SHALL:handle
                                                                                                                                                                                                                                  SHALL:handle
                                                                                                                                                                                                                                  30. CancerEpisode.hnClassification.histologyOdontogenicCarcinoma
                                                                                                                                                                                                                                  Definition

                                                                                                                                                                                                                                  Specifies the histological subgroup for odontogenic carcinomas

                                                                                                                                                                                                                                  ShortHistology Odontogenic Carcinoma
                                                                                                                                                                                                                                  Comments

                                                                                                                                                                                                                                  Odontogenic carcinoma, NOS, Ameloblastic carcinoma (primary, secondary intraosseous, secondary peripheral), Primary intraosseous carcinoma, Intraosseous carcinoma developed on odontogenic cyst, sclerosing odontogenic carcinoma; Clear cell odontogenic carcinoma; Gosht cell odontogenic carcinoma Odontogenic carcinoma, NOS - 4098585 Ameloblastic carcinoma (primary, secondary intraosseous, secondary peripheral) - 37116638 Secondary dedifferentiated intraosseous ameloblastic carcinoma

                                                                                                                                                                                                                                  • 37116980 Secondary dedifferentiated peripheral ameloblastic carcinoma - 37116979 Primary intraosseous carcinoma - 37117009 Intraosseous carcinoma developed on odontogenic cyst - 37116887 sclerosing odontogenic carcinoma Clear cell odontogenic carcinoma - 734032001 Gosht cell odontogenic carcinoma - 37312303
                                                                                                                                                                                                                                  Control1..1
                                                                                                                                                                                                                                  TypeCodeableConcept
                                                                                                                                                                                                                                  Obligations
                                                                                                                                                                                                                                    ObligationsActor
                                                                                                                                                                                                                                    SHALL:handle
                                                                                                                                                                                                                                    SHALL:handle
                                                                                                                                                                                                                                    32. CancerEpisode.hnClassification.histologySNUC
                                                                                                                                                                                                                                    Definition

                                                                                                                                                                                                                                    Specifies the histological subgroup for sinonasl undifferentiated carcinomas

                                                                                                                                                                                                                                    ShortHistology Sinonasal undifferentiated carcinoma
                                                                                                                                                                                                                                    Comments

                                                                                                                                                                                                                                    SMARCB1 (INI-1)-deficient Sinonasal undifferentiated Carcinoma;Sinonasal SMARCA4 deficient carcinoma;IDH2-mutated sinonasal undifferentiated neoplasm SMARCB1 (INI-1)-deficient Sinonasal undifferentiated Carcinoma Sinonasal SMARCA4 deficient carcinoma IDH2-mutated sinonasal undifferentiated neoplasm

                                                                                                                                                                                                                                    Control1..1
                                                                                                                                                                                                                                    TypeCodeableConcept
                                                                                                                                                                                                                                    Obligations
                                                                                                                                                                                                                                      ObligationsActor
                                                                                                                                                                                                                                      SHALL:handle
                                                                                                                                                                                                                                      SHALL:handle
                                                                                                                                                                                                                                      34. CancerEpisode.sarcomaClassification
                                                                                                                                                                                                                                      Definition

                                                                                                                                                                                                                                      Sarcoma classification

                                                                                                                                                                                                                                      ShortSarcoma classification
                                                                                                                                                                                                                                      Control1..1
                                                                                                                                                                                                                                      TypeBackboneElement
                                                                                                                                                                                                                                      Obligations
                                                                                                                                                                                                                                        ObligationsActor
                                                                                                                                                                                                                                        SHALL:handle
                                                                                                                                                                                                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                                                                                                                                        36. CancerEpisode.sarcomaClassification.id
                                                                                                                                                                                                                                        Definition

                                                                                                                                                                                                                                        Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                                                                                                                                                                                        ShortUnique id for inter-element referencing
                                                                                                                                                                                                                                        Control0..1
                                                                                                                                                                                                                                        Typestring
                                                                                                                                                                                                                                        Is Modifierfalse
                                                                                                                                                                                                                                        XML FormatIn the XML format, this property is represented as an attribute.
                                                                                                                                                                                                                                        Summaryfalse
                                                                                                                                                                                                                                        38. CancerEpisode.sarcomaClassification.extension
                                                                                                                                                                                                                                        Definition

                                                                                                                                                                                                                                        May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                                                                                                                                                                                                                        ShortAdditional content defined by implementations
                                                                                                                                                                                                                                        Comments

                                                                                                                                                                                                                                        There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                                                                                                                                                                        Control0..*
                                                                                                                                                                                                                                        TypeExtension
                                                                                                                                                                                                                                        Is Modifierfalse
                                                                                                                                                                                                                                        Summaryfalse
                                                                                                                                                                                                                                        Alternate Namesextensions, user content
                                                                                                                                                                                                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                                                                                                                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                                                                                                                                                        SlicingThis element introduces a set of slices on CancerEpisode.sarcomaClassification.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                                                                                                                                                                                                        • value @ url
                                                                                                                                                                                                                                        • 40. CancerEpisode.sarcomaClassification.modifierExtension
                                                                                                                                                                                                                                          Definition

                                                                                                                                                                                                                                          May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                                                                                                                                                                                                                          Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                                                                                                                                                                                                                          ShortExtensions that cannot be ignored even if unrecognized
                                                                                                                                                                                                                                          Comments

                                                                                                                                                                                                                                          There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                                                                                                                                                                          Control0..*
                                                                                                                                                                                                                                          TypeExtension
                                                                                                                                                                                                                                          Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                                                                                                                                                                                                                          Summarytrue
                                                                                                                                                                                                                                          Requirements

                                                                                                                                                                                                                                          Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                                                                                                                                                                                                                          Alternate Namesextensions, user content, modifiers
                                                                                                                                                                                                                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                                                                                                                                          ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                                                                                                                                                          42. CancerEpisode.sarcomaClassification.adipocyticTumours
                                                                                                                                                                                                                                          Definition

                                                                                                                                                                                                                                          Specifies the histological subgroup for adipocytic tumours

                                                                                                                                                                                                                                          ShortHistology subgroup Adipocytic tumours
                                                                                                                                                                                                                                          Comments

                                                                                                                                                                                                                                          Atypical lipomatous tumour/ Liposarcoma, well-differentiated, NOS Dedifferentiated liposarcoma Myxoid liposarcoma Pleomorphic liposarcoma Myxoid pleomorphic liposarcoma

                                                                                                                                                                                                                                          Liposarcoma, well differentiated - 4102790 Dedifferentiated liposarcoma - 4284833 Myxoid liposarcoma - 4101123 Pleomorphic liposarcoma - 4010104 Myxoid pleomorphic liposarcoma - 4300687

                                                                                                                                                                                                                                          Control1..1
                                                                                                                                                                                                                                          TypeCodeableConcept
                                                                                                                                                                                                                                          Obligations
                                                                                                                                                                                                                                            ObligationsActor
                                                                                                                                                                                                                                            SHALL:handle
                                                                                                                                                                                                                                            44. CancerEpisode.sarcomaClassification.fmtTumours
                                                                                                                                                                                                                                            Definition

                                                                                                                                                                                                                                            Histology subgroup Fibroblastic and myofibroblastic tumours

                                                                                                                                                                                                                                            ShortHistology subgroup Fibroblastic and myofibroblastic tumours
                                                                                                                                                                                                                                            Comments

                                                                                                                                                                                                                                            Palmar/plantar-type fibromatosis Desmoid-type fibromatosis Lipofibromatosis Giant cell fibroblastoma Dermatofibrosarcoma protuberans NOS Solitary fibrous tumour, benign; NOS; malignant Inflammatory myofibroblastic tumour Low-grade myofibroblastic sarcoma Superficial CD34-positive fibroblastic tumour Myxoinflammatory fibroblastic sarcoma Infantile fibrosarcoma Adult fibrosarcoma Myxofibrosarcoma Low-grade fibromyxoid sarcoma Sclerosing epithelioid fibrosarcoma

                                                                                                                                                                                                                                            Palmar/plantar-type fibromatosis - 45766452 Desmoid-type fibromatosis - 4264204 Lipofibromatosis - 45766468 Giant cell fibroblastoma - 4030132 Dermatofibrosarcoma protuberans - 4295283 Solitary fibrous tumor - 4030130 Solitary fibrous tumor, malignant - 4028562 Myofibroblastic tumour - 4021373 Low-grade myofibroblastic sarcoma - 45766454 Cellular fibroma - 4029679 Myxoinflammatory fibroblastic sarcoma - 45766450 Infantile fibrosarcoma - 4178132 Fibrosarcoma - 4202374 Myxofibrosarcoma - 45771359 Low-grade fibromyxoid sarcoma - 45771361 Sclerosing epithelioid fibrosarcoma - 45766456

                                                                                                                                                                                                                                            Control1..1
                                                                                                                                                                                                                                            TypeCodeableConcept
                                                                                                                                                                                                                                            Obligations
                                                                                                                                                                                                                                              ObligationsActor
                                                                                                                                                                                                                                              SHALL:handle
                                                                                                                                                                                                                                              46. CancerEpisode.sarcomaClassification.socalledFibrohistiocyticTumours
                                                                                                                                                                                                                                              Definition

                                                                                                                                                                                                                                              Histology subgroup So-called fibrohistiocytic tumours

                                                                                                                                                                                                                                              ShortHistology subgroup So-called fibrohistiocytic tumours
                                                                                                                                                                                                                                              Comments

                                                                                                                                                                                                                                              Plexiform fibrohistiocytic tumour Giant cell tumour of soft parts NOS Tenosynovial giant cell tumor

                                                                                                                                                                                                                                              Plexiform fibrohistiocytic tumour - 4029525 Giant cell tumour of soft parts - 4218898 Tenosynovial giant cell tumor - 4030140 Tenosynovial giant cell tumor, diffuse - 45766525 Malignant tenosynovial giant cell tumor - 4029655

                                                                                                                                                                                                                                              Control1..1
                                                                                                                                                                                                                                              TypeCodeableConcept
                                                                                                                                                                                                                                              Obligations
                                                                                                                                                                                                                                                ObligationsActor
                                                                                                                                                                                                                                                SHALL:handle
                                                                                                                                                                                                                                                48. CancerEpisode.sarcomaClassification.vascularTumours
                                                                                                                                                                                                                                                Definition

                                                                                                                                                                                                                                                Vascular tumours

                                                                                                                                                                                                                                                ShortVascular tumours
                                                                                                                                                                                                                                                Comments

                                                                                                                                                                                                                                                Epithelioid haemangioendothelioma NOS Angiosarcoma Kaposiform haemangioendothelioma ha anche la forma benigna 9161/0 Acquired tufted haemangioma. teniamo anche la fomra benigna? Retiform haemangioendothelioma Papillary intralymphatic angioendothelioma Composite haemangioendothelioma Pseudomyogenic (epithelioid sarcoma?like) haemangioendothelioma

                                                                                                                                                                                                                                                Epithelioid haemangioendothelioma - 4207381 Angiosarcoma - 3661612 Hemangioendothelioma - 4281384 Retiform haemangioendothelioma - 45766493 Endovascular papillary angioendothelioma - 4030138 Composite haemangioendothelioma - 45766494 Pseudomyogenic (epithelioid sarcoma-like) hemangioendothelioma - 45766492

                                                                                                                                                                                                                                                Control1..1
                                                                                                                                                                                                                                                TypeCodeableConcept
                                                                                                                                                                                                                                                Obligations
                                                                                                                                                                                                                                                  ObligationsActor
                                                                                                                                                                                                                                                  SHALL:handle
                                                                                                                                                                                                                                                  50. CancerEpisode.sarcomaClassification.pericyticPerivascularTumours
                                                                                                                                                                                                                                                  Definition

                                                                                                                                                                                                                                                  Pericytic (perivascular) tumours

                                                                                                                                                                                                                                                  ShortPericytic (perivascular) tumours
                                                                                                                                                                                                                                                  Comments

                                                                                                                                                                                                                                                  Glomus tumour NOS

                                                                                                                                                                                                                                                  Glomus tumour - 40571984

                                                                                                                                                                                                                                                  Control1..1
                                                                                                                                                                                                                                                  TypeCodeableConcept
                                                                                                                                                                                                                                                  Obligations
                                                                                                                                                                                                                                                    ObligationsActor
                                                                                                                                                                                                                                                    SHALL:handle
                                                                                                                                                                                                                                                    52. CancerEpisode.sarcomaClassification.smoothMuscleTumours
                                                                                                                                                                                                                                                    Definition

                                                                                                                                                                                                                                                    Smooth muscle tumours

                                                                                                                                                                                                                                                    ShortSmooth muscle tumours
                                                                                                                                                                                                                                                    Comments

                                                                                                                                                                                                                                                    Smooth muscle tumour of uncertain malignant potential Epithelioid smooth muscle tumor of uncertain malignant potential Myxoid smooth muscle tumour of uncertain mailgnant potential-Spindle smooth muscle tumor of uncertain malignant potential Metastasizing leiomyoma Leiomyosarcoma NOS Epithelioid leiomyosarcoma Myxoid leiomyosarcoma Metastasizing leiomyoma

                                                                                                                                                                                                                                                    Smooth muscle tumour - 4327493 Epithelioid smooth muscle tumor of uncertain malignant potential - 607803 Myxoid smooth muscle tumour of uncertain mailgnant potential - 600675 Spindle smooth muscle tumor of uncertain malignant potential Metastasizing leiomyoma - 4029023 Leiomyosarcoma - 4201415 Epithelioid leiomyosarcoma - 4173148 Myxoid leiomyosarcoma - 4059632 Metastasizing leiomyoma - 4029023

                                                                                                                                                                                                                                                    Control1..1
                                                                                                                                                                                                                                                    TypeCodeableConcept
                                                                                                                                                                                                                                                    Obligations
                                                                                                                                                                                                                                                      ObligationsActor
                                                                                                                                                                                                                                                      SHALL:handle
                                                                                                                                                                                                                                                      54. CancerEpisode.sarcomaClassification.skeletalMuscleTumours
                                                                                                                                                                                                                                                      Definition

                                                                                                                                                                                                                                                      Skeletal muscle tumours

                                                                                                                                                                                                                                                      ShortSkeletal muscle tumours
                                                                                                                                                                                                                                                      Comments

                                                                                                                                                                                                                                                      Embryonal rhabdomyosarcoma NOS Alveolar rhabdomyosarcoma Pleomorphic rhabdomyosarcoma NOS Spindle cell / sclerosing rhabdomyosarcoma Ectomesenchymoma

                                                                                                                                                                                                                                                      Embryonal rhabdomyosarcoma - 4031038 Alveolar rhabdomyosarcoma - 4272931 Pleomorphic rhabdomyosarcoma - 4298312 Spindle cell rhabdomyosarcoma - 4029528 Rhabdomyosarcoma with ganglionic differentiation - 4029024

                                                                                                                                                                                                                                                      Control1..1
                                                                                                                                                                                                                                                      TypeCodeableConcept
                                                                                                                                                                                                                                                      Obligations
                                                                                                                                                                                                                                                        ObligationsActor
                                                                                                                                                                                                                                                        SHALL:handle
                                                                                                                                                                                                                                                        56. CancerEpisode.sarcomaClassification.chondroOsseousTumours
                                                                                                                                                                                                                                                        Definition

                                                                                                                                                                                                                                                        Chondro-osseous tumours

                                                                                                                                                                                                                                                        ShortChondro-osseous tumours
                                                                                                                                                                                                                                                        Comments

                                                                                                                                                                                                                                                        Extraskeletal osteosarcoma

                                                                                                                                                                                                                                                        Extraskeletal osteosarcoma - 4298240

                                                                                                                                                                                                                                                        Control1..1
                                                                                                                                                                                                                                                        TypeCodeableConcept
                                                                                                                                                                                                                                                        Obligations
                                                                                                                                                                                                                                                          ObligationsActor
                                                                                                                                                                                                                                                          SHALL:handle
                                                                                                                                                                                                                                                          58. CancerEpisode.sarcomaClassification.peripheralNerveSheathTumours
                                                                                                                                                                                                                                                          Definition

                                                                                                                                                                                                                                                          Peripheral nerve sheath tumours

                                                                                                                                                                                                                                                          ShortPeripheral nerve sheath tumours
                                                                                                                                                                                                                                                          Comments

                                                                                                                                                                                                                                                          Malignant peripheral nerve sheath tumour NOS Malignant melanotic nerve sheath tumour Granular cell tumour NOS Granular cell tumour, malignant

                                                                                                                                                                                                                                                          Malignant peripheral nerve sheath tumour - 4062426 Melanotic malignant peripheral nerve sheath tumor - 4102399 Granular cell tumour - 4005360 Granular cell tumour, malignant - 4027842

                                                                                                                                                                                                                                                          Control1..1
                                                                                                                                                                                                                                                          TypeCodeableConcept
                                                                                                                                                                                                                                                          Obligations
                                                                                                                                                                                                                                                            ObligationsActor
                                                                                                                                                                                                                                                            SHALL:handle
                                                                                                                                                                                                                                                            60. CancerEpisode.sarcomaClassification.tumoursOfUncertainDifferentiation
                                                                                                                                                                                                                                                            Definition

                                                                                                                                                                                                                                                            Tumours of uncertain differentiation

                                                                                                                                                                                                                                                            ShortTumours of uncertain differentiation
                                                                                                                                                                                                                                                            Comments

                                                                                                                                                                                                                                                            Atypical fibroxanthoma Angiomatoid fibrous histiocytoma Pleomorphic hyalinizing angiectatic tumour Haemosiderotic fibrolipomatous tumour NTRK-rearranged spindle cell neoplasms Synovial sarcoma NOS Epithelioid sarcoma Alveolar soft part sarcoma Clear cell sarcoma NOS Extra-skeletal myxoid chondrosarcoma Desmoplastic small round cell tumour Extra-renal rhabdoid tumour NOS PEComas Intimal sarcoma Undifferentiated sarcoma Myoepithelioma Ossifying fibromyxoid tumour Phosphaturic mesenchymal tumour, malignant Aggressive angiomyxoma Angiomatoid fibrous histiocytoma NTRK-rearranged spindle cell neoplasm (emerging)

                                                                                                                                                                                                                                                                Atypical fibrous histiocytoma - 4096931
                                                                                                                                                                                                                                                            

                                                                                                                                                                                                                                                            Angiomatoid fibrous histiocytoma - 4029526 Pleomorphic hyalinizing angiectatic tumour - 45766448 Haemosiderotic fibrolipomatous tumour NTRK-rearranged spindle cell neoplasms - CUSTOM CODE Synovial sarcoma - 4268491 Epithelioid sarcoma - 4244886 Alveolar soft part sarcoma - 4339208 Clear cell sarcoma - 4155072 Myxoid chondrosarcoma - 4328092 Desmoplastic small round cell tumor - 4029522 Malignant rhabdoid tumor - 4307938 Perivascular epithelioid tumor, benign - 45771358 Perivascular epithelioid tumor, malignant - 45766447 Perivascular epithelioid cell tumor - 4304780 Intimal sarcoma - 45766495 Undifferentiated sarcoma - 4029021 Myoepithelioma - 4239519 Ossifying fibromyxoid tumour - 4028565 Phosphaturic mesenchymal tumour, malignant - 45766485 Aggressive angiomyxoma - 4239956 Angiomatoid fibrous histiocytoma - 4029526 NTRK-rearranged spindle cell neoplasm (emerging)

                                                                                                                                                                                                                                                            Control1..1
                                                                                                                                                                                                                                                            TypeCodeableConcept
                                                                                                                                                                                                                                                            Obligations
                                                                                                                                                                                                                                                              ObligationsActor
                                                                                                                                                                                                                                                              SHALL:handle
                                                                                                                                                                                                                                                              62. CancerEpisode.sarcomaClassification.undifSmallRCelSarcBonAndSofTis
                                                                                                                                                                                                                                                              Definition

                                                                                                                                                                                                                                                              Undifferentiated small round cell sarcomas of bone and soft tissue

                                                                                                                                                                                                                                                              ShortUndifferentiated small round cell sarcomas of bone and soft tissue
                                                                                                                                                                                                                                                              Comments

                                                                                                                                                                                                                                                              Ewing sarcoma Round cell sarcoma with�EWSR1?non-ETS fusions CIC-rearranged sarcoma Sarcoma with�BCOR�genetic alterations

                                                                                                                                                                                                                                                              Ewing sarcoma - 45766528 Round cell sarcoma with�EWSR1?non-ETS fusions CIC-rearranged sarcoma Sarcoma with�BCOR�genetic alterations

                                                                                                                                                                                                                                                              Control1..1
                                                                                                                                                                                                                                                              TypeCodeableConcept
                                                                                                                                                                                                                                                              Obligations
                                                                                                                                                                                                                                                                ObligationsActor
                                                                                                                                                                                                                                                                SHALL:handle
                                                                                                                                                                                                                                                                64. CancerEpisode.sarcomaClassification.estAndRelatedTumours
                                                                                                                                                                                                                                                                Definition

                                                                                                                                                                                                                                                                Endometrial stromal and related tumours

                                                                                                                                                                                                                                                                ShortEndometrial stromal and related tumours
                                                                                                                                                                                                                                                                Comments

                                                                                                                                                                                                                                                                Endometrial stromal sarcoma, high grade Endometrial stromal sarcoma, low grade

                                                                                                                                                                                                                                                                Endometrial stromal sarcoma, high grade - 4290926 Endometrial stromal sarcoma, low grade - 4028557

                                                                                                                                                                                                                                                                Control1..1
                                                                                                                                                                                                                                                                TypeCodeableConcept
                                                                                                                                                                                                                                                                Obligations
                                                                                                                                                                                                                                                                  ObligationsActor
                                                                                                                                                                                                                                                                  SHALL:handle
                                                                                                                                                                                                                                                                  66. CancerEpisode.sarcomaClassification.miscellaniousMesenchimalTumors
                                                                                                                                                                                                                                                                  Definition

                                                                                                                                                                                                                                                                  Miscellanious mesenchimal tumors

                                                                                                                                                                                                                                                                  ShortMiscellanious mesenchimal tumors
                                                                                                                                                                                                                                                                  Comments

                                                                                                                                                                                                                                                                  Uterine tumour resembling ovarian sex cord tumour Phyllodes tumour, benign Phyllodes tumour NOS Phyllodes tumour, borderline Phyllodes tumour, malignant Follicular dendritic cell sarcoma Histiocytic sarcoma Interdigitating dendritic cell sarcoma Langherans cell sarcoma Fibroblastic reticular cell tumour Biphenotypic sinonasal sarcoma

                                                                                                                                                                                                                                                                  Uterine tumour resembling ovarian sex cord tumour - 45771357 Benign phyllodes tumor - 4040991 Borderline phyllodes tumor - 4323562 Phyllodes tumour, malignant - 4337106 Follicular dendritic cell sarcoma - 4028710 Histiocytic sarcoma - 4029172 Interdigitating dendritic cell sarcoma - 4028709 Langherans cell sarcoma - 4029173 Fibroblastic reticular cell tumour - 42872917 Biphenotypic sinonasal sarcoma - 37311513

                                                                                                                                                                                                                                                                  Control1..1
                                                                                                                                                                                                                                                                  TypeCodeableConcept
                                                                                                                                                                                                                                                                  Obligations
                                                                                                                                                                                                                                                                    ObligationsActor
                                                                                                                                                                                                                                                                    SHALL:handle
                                                                                                                                                                                                                                                                    68. CancerEpisode.sarcomaClassification.mixedEpithelialAndMesenchymalTumours
                                                                                                                                                                                                                                                                    Definition

                                                                                                                                                                                                                                                                    Mixed epithelial and mesenchymal tumours

                                                                                                                                                                                                                                                                    ShortMixed epithelial and mesenchymal tumours
                                                                                                                                                                                                                                                                    Comments

                                                                                                                                                                                                                                                                    Adenosarcoma; please clarify if adenosarcoma with sarcomatous overgrowth

                                                                                                                                                                                                                                                                    Adenosarcoma - 4135215

                                                                                                                                                                                                                                                                    Control1..1
                                                                                                                                                                                                                                                                    TypeCodeableConcept
                                                                                                                                                                                                                                                                    Obligations
                                                                                                                                                                                                                                                                      ObligationsActor
                                                                                                                                                                                                                                                                      SHALL:handle
                                                                                                                                                                                                                                                                      70. CancerEpisode.subsites
                                                                                                                                                                                                                                                                      Definition

                                                                                                                                                                                                                                                                      subsites

                                                                                                                                                                                                                                                                      Shortsubsites
                                                                                                                                                                                                                                                                      Control1..1
                                                                                                                                                                                                                                                                      TypeBackboneElement
                                                                                                                                                                                                                                                                      Obligations
                                                                                                                                                                                                                                                                        ObligationsActor
                                                                                                                                                                                                                                                                        SHALL:handle
                                                                                                                                                                                                                                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                                                                                                                                                                        72. CancerEpisode.subsites.id
                                                                                                                                                                                                                                                                        Definition

                                                                                                                                                                                                                                                                        Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                                                                                                                                                                                                                        ShortUnique id for inter-element referencing
                                                                                                                                                                                                                                                                        Control0..1
                                                                                                                                                                                                                                                                        Typestring
                                                                                                                                                                                                                                                                        Is Modifierfalse
                                                                                                                                                                                                                                                                        XML FormatIn the XML format, this property is represented as an attribute.
                                                                                                                                                                                                                                                                        Summaryfalse
                                                                                                                                                                                                                                                                        74. CancerEpisode.subsites.extension
                                                                                                                                                                                                                                                                        Definition

                                                                                                                                                                                                                                                                        May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                                                                                                                                                                                                                                                        ShortAdditional content defined by implementations
                                                                                                                                                                                                                                                                        Comments

                                                                                                                                                                                                                                                                        There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                                                                                                                                                                                                        Control0..*
                                                                                                                                                                                                                                                                        TypeExtension
                                                                                                                                                                                                                                                                        Is Modifierfalse
                                                                                                                                                                                                                                                                        Summaryfalse
                                                                                                                                                                                                                                                                        Alternate Namesextensions, user content
                                                                                                                                                                                                                                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                                                                                                                                                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                                                                                                                                                                                        SlicingThis element introduces a set of slices on CancerEpisode.subsites.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                                                                                                                                                                                                                                        • value @ url
                                                                                                                                                                                                                                                                        • 76. CancerEpisode.subsites.modifierExtension
                                                                                                                                                                                                                                                                          Definition

                                                                                                                                                                                                                                                                          May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                                                                                                                                                                                                                                                          Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                                                                                                                                                                                                                                                          ShortExtensions that cannot be ignored even if unrecognized
                                                                                                                                                                                                                                                                          Comments

                                                                                                                                                                                                                                                                          There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                                                                                                                                                                                                          Control0..*
                                                                                                                                                                                                                                                                          TypeExtension
                                                                                                                                                                                                                                                                          Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                                                                                                                                                                                                                                                          Summarytrue
                                                                                                                                                                                                                                                                          Requirements

                                                                                                                                                                                                                                                                          Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                                                                                                                                                                                                                                                          Alternate Namesextensions, user content, modifiers
                                                                                                                                                                                                                                                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                                                                                                                                                                          ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                                                                                                                                                                                          78. CancerEpisode.subsites.nasalCavityAndParanasalSinuses
                                                                                                                                                                                                                                                                          Definition

                                                                                                                                                                                                                                                                          Specifies the subsite for cancers occurred in nasal cavity and paranasal sinusess

                                                                                                                                                                                                                                                                          ShortNasal cavity and paranasal sinuses subsite
                                                                                                                                                                                                                                                                          Comments

                                                                                                                                                                                                                                                                          AJCC 8th Edition Cancer Staging Manual

                                                                                                                                                                                                                                                                          Nasal cavity;Maxillary sinus;Ethmoid sinus;Frontal sinus;Sphenoid sinus Nasal cavity - 4088327 Maxillary sinus - 4050631 Ethmoid sinus - 4182234 Frontal sinus - 4204534 Sphenoid sinus - 4097172

                                                                                                                                                                                                                                                                          Control1..1
                                                                                                                                                                                                                                                                          TypeCodeableConcept
                                                                                                                                                                                                                                                                          Obligations
                                                                                                                                                                                                                                                                            ObligationsActor
                                                                                                                                                                                                                                                                            SHALL:handle
                                                                                                                                                                                                                                                                            80. CancerEpisode.subsites.nasopharynx
                                                                                                                                                                                                                                                                            Definition

                                                                                                                                                                                                                                                                            Specifies the subsite for cancers occurred in nasopharynx

                                                                                                                                                                                                                                                                            ShortNasopharynx subsite
                                                                                                                                                                                                                                                                            Comments

                                                                                                                                                                                                                                                                            AJCC 8th Edition Cancer Staging Manual

                                                                                                                                                                                                                                                                            Superior wall of nasopharynx;Posterior wall of nasopharynx;Lateral wall of nasopharynx;Anterior wall of nasopharynx Superior wall of nasopharynx - 4068978 Posterior wall of nasopharynx - 4146741 Lateral wall of nasopharynx - 4323979 Anterior wall of nasopharynx - 4220236

                                                                                                                                                                                                                                                                            Control1..1
                                                                                                                                                                                                                                                                            TypeCodeableConcept
                                                                                                                                                                                                                                                                            Obligations
                                                                                                                                                                                                                                                                              ObligationsActor
                                                                                                                                                                                                                                                                              SHALL:handle
                                                                                                                                                                                                                                                                              82. CancerEpisode.subsites.hypopharynx
                                                                                                                                                                                                                                                                              Definition

                                                                                                                                                                                                                                                                              Specifies the subsite for cancers occurred in hypopharynx

                                                                                                                                                                                                                                                                              ShortHypopharynx subsite
                                                                                                                                                                                                                                                                              Comments

                                                                                                                                                                                                                                                                              AJCC 8th Edition Cancer Staging Manual

                                                                                                                                                                                                                                                                              Postcricoid region; Hypopharyngeal aspect of aryepiglottic fold; Posterior wall of hypopharynx;Pyriform sinus

                                                                                                                                                                                                                                                                              Postcricoid region - 4147741 Hypopharyngeal aspect of aryepiglottic fold - 4262980 Posterior wall of hypopharynx - 4102600 Pyriform sinus - 4268741

                                                                                                                                                                                                                                                                              Control1..1
                                                                                                                                                                                                                                                                              TypeCodeableConcept
                                                                                                                                                                                                                                                                              Obligations
                                                                                                                                                                                                                                                                                ObligationsActor
                                                                                                                                                                                                                                                                                SHALL:handle
                                                                                                                                                                                                                                                                                84. CancerEpisode.subsites.oropharynx
                                                                                                                                                                                                                                                                                Definition

                                                                                                                                                                                                                                                                                Specifies the subsite for cancers occurred in oropharynx

                                                                                                                                                                                                                                                                                ShortOropharynx subsite
                                                                                                                                                                                                                                                                                Comments

                                                                                                                                                                                                                                                                                https://link.springer.com/book/9783319406176

                                                                                                                                                                                                                                                                                Base of tongue, NOS; Soft palate NOS (excludes Nasopharyngcal surface C11.3); Uvula; Tonsillar fossa; Lingual tonsil; Tonsillar pillar; Vallecula; Anterior surface of epiglottis; Lateral wall oropharynx; Posterior wall oropharynx; Branchial cleft (site of neoplosm);

                                                                                                                                                                                                                                                                                Base of tongue, NOS - 4169910 Soft palate NOS (excludes Nasopharyngcal surface C11.3) - 4177005 Uvula - 4095284 Tonsillar fossa - 4138234 Lingual tonsil - 4068841 Tonsillar pillar - 4065073 Vallecula - 4173123 Anterior surface of epiglottis - 4283238 Lateral wall oropharynx - 4078066 Posterior wall oropharynx - 4045435 Branchial cleft (site of neoplosm) - 4235649

                                                                                                                                                                                                                                                                                Control1..1
                                                                                                                                                                                                                                                                                TypeCodeableConcept
                                                                                                                                                                                                                                                                                Obligations
                                                                                                                                                                                                                                                                                  ObligationsActor
                                                                                                                                                                                                                                                                                  SHALL:handle
                                                                                                                                                                                                                                                                                  86. CancerEpisode.subsites.larynx
                                                                                                                                                                                                                                                                                  Definition

                                                                                                                                                                                                                                                                                  Specifies the subsite for cancers occurred in larynx

                                                                                                                                                                                                                                                                                  ShortLarynx subsite
                                                                                                                                                                                                                                                                                  Comments

                                                                                                                                                                                                                                                                                  AJCC 8th Edition Cancer Staging Manual Glottis;Supraglottis;Subglottis;Laryngeal cartilage

                                                                                                                                                                                                                                                                                  Glottis - 4047227 Supraglottis - 4001049 Subglottis - 4002724 Laryngeal cartilage - 4279711

                                                                                                                                                                                                                                                                                  Control1..1
                                                                                                                                                                                                                                                                                  TypeCodeableConcept
                                                                                                                                                                                                                                                                                  Obligations
                                                                                                                                                                                                                                                                                    ObligationsActor
                                                                                                                                                                                                                                                                                    SHALL:handle
                                                                                                                                                                                                                                                                                    88. CancerEpisode.subsites.oralCavity
                                                                                                                                                                                                                                                                                    Definition

                                                                                                                                                                                                                                                                                    Specifies the subsite for cancers occurred in oral cavity

                                                                                                                                                                                                                                                                                    ShortOral cavity subsite
                                                                                                                                                                                                                                                                                    Comments

                                                                                                                                                                                                                                                                                    AJCC 8th Edition Cancer Staging Manual

                                                                                                                                                                                                                                                                                    Dorsal surface tongue, NOS; Border of tongue; Ventral surface of tongue NOS; Anterior 2/3 of tongue NOS; Upper gum; Lower gum; Anterior floor of mouth; Lateral floor of mouth; Overlapping lesion of floor of mouth; Hard palate; Cheek mucosa; Vestibule of mouth; Retromolar area; Overlapping lesion of other and unspecified parts of mouth; Dorsal surface tongue, NOS - 36769609 Border of tongue - 4077986 Ventral surface of tongue - 4172794 Anterior 2/3 of tongue NOS Upper gum - 4047029 Lower gum - 4210919 Anterior floor of mouth - 4181419 Lateral floor of mouth - 4103066 Overlapping lesion of floor of mouth - 44498040 Hard palate - 4234542 Cheek mucosa - 4057160 Vestibule of mouth - 4144069 Retromolar area - 36769865 Overlapping lesion of other and unspecified parts of mouth -

                                                                                                                                                                                                                                                                                    Control1..1
                                                                                                                                                                                                                                                                                    TypeCodeableConcept
                                                                                                                                                                                                                                                                                    Obligations
                                                                                                                                                                                                                                                                                      ObligationsActor
                                                                                                                                                                                                                                                                                      SHALL:handle
                                                                                                                                                                                                                                                                                      90. CancerEpisode.subsites.lip
                                                                                                                                                                                                                                                                                      Definition

                                                                                                                                                                                                                                                                                      Specifies the subsite for cancers occurred in lip

                                                                                                                                                                                                                                                                                      ShortLip subsite
                                                                                                                                                                                                                                                                                      Comments

                                                                                                                                                                                                                                                                                      AJCC 8th Edition Cancer Staging Manual

                                                                                                                                                                                                                                                                                      External lower lip;External upper lip;External lip, NOS;Mucosa of upper lip;Mucosa of lower lip;Mucosa of lip, NOS;Commissure of lip External lower lip - 4027546 External upper lip - 4134589 External lip, NOS - 4027545 Mucosa of upper lip - 36769700 Mucosa of lower lip - 36768548 Mucosa of lip, NOS - 4245168 Commissure of lip - 4307358

                                                                                                                                                                                                                                                                                      Control1..1
                                                                                                                                                                                                                                                                                      TypeCodeableConcept
                                                                                                                                                                                                                                                                                      Obligations
                                                                                                                                                                                                                                                                                        ObligationsActor
                                                                                                                                                                                                                                                                                        SHALL:handle
                                                                                                                                                                                                                                                                                        92. CancerEpisode.subsites.upperAndLowerLimbs
                                                                                                                                                                                                                                                                                        Definition

                                                                                                                                                                                                                                                                                        Specifies the subsite for cancers occurred in

                                                                                                                                                                                                                                                                                        ShortUpper and Lower limbs subsite
                                                                                                                                                                                                                                                                                        Comments

                                                                                                                                                                                                                                                                                        Hand Wrist Forearm Elbow/Antecubital fossa Upper arm Foot Ankle Leg Knee/popliteal fossa Upper leg Deltoid Supraclavicular Periscapular Trapezius Groin Buttock Pectoral Axilla

                                                                                                                                                                                                                                                                                        Hand structure - 4310976 Wrist region structure - 4220073 Forearm structure - 4032953 Elbow region structure - 4027910 Antecubital fossa (surface region) - 4348994 Upper arm structure - 4165266 Foot structure- 4211098 Ankle region structure - 4142359 Lower leg structure - 4107527 Knee region structure - 4217806 popliteal fossa structure - 4138531 Upper leg - 4090445 Deltoid - 4291935 Supraclavicular - 4088464 Periscapular region - 42605854 Trapezius - 4136969 Groin - 4109459 Buttock - 4263335 Pectoral - 4096078 Axilla - 4157836

                                                                                                                                                                                                                                                                                        Control1..1
                                                                                                                                                                                                                                                                                        TypeCodeableConcept
                                                                                                                                                                                                                                                                                        Obligations
                                                                                                                                                                                                                                                                                          ObligationsActor
                                                                                                                                                                                                                                                                                          SHALL:handle
                                                                                                                                                                                                                                                                                          94. CancerEpisode.subsites.trunkWallSubsite
                                                                                                                                                                                                                                                                                          Definition

                                                                                                                                                                                                                                                                                          Specifies the subsite for cancers occurred in

                                                                                                                                                                                                                                                                                          ShortTrunk wall subsite
                                                                                                                                                                                                                                                                                          Comments

                                                                                                                                                                                                                                                                                          Thoracic Wall Abdominal Wall Paravertebral ? thoracolumbar Paravertebral ? cervical

                                                                                                                                                                                                                                                                                          Joint structure of thoracic wall - 4088614 Anterior abdominal wall structure - 4244412 Posterior abdominal wall structure - 4330865 Paravertebral ? thoracolumbar - Paravertebral ? cervical

                                                                                                                                                                                                                                                                                          Control1..1
                                                                                                                                                                                                                                                                                          TypeCodeableConcept
                                                                                                                                                                                                                                                                                          Obligations
                                                                                                                                                                                                                                                                                            ObligationsActor
                                                                                                                                                                                                                                                                                            SHALL:handle
                                                                                                                                                                                                                                                                                            96. CancerEpisode.subsites.intraAbdominalSubsite
                                                                                                                                                                                                                                                                                            Definition

                                                                                                                                                                                                                                                                                            Specifies the subsite for cancers occurred in

                                                                                                                                                                                                                                                                                            ShortIntra abdominal subsite
                                                                                                                                                                                                                                                                                            Comments

                                                                                                                                                                                                                                                                                            Retroperitoneum Vessels (please select: inferior vena cava, aorta, iliac vessels, renal vessels, gonadal vessels, mesenteric vessels, others) Pelvis Esophagus Stomach Duodenum Jejunum/Ileus Colon Rectum Mesentery

                                                                                                                                                                                                                                                                                            Retroperitoneal compartment structure - 4220536 Vessels (please select: inferior vena cava, aorta, iliac vessels, renal vessels, gonadal vessels, mesenteric vessels, others) Inferior vena cava structure - 4271699 Iliac vessel - 4193451 Structure of renal artery - 4154880 Gonadal artery - 4157844 Structure of mesenteric artery - 4314264 Other vessels - WILDCARD* Renal pelvis structure - 4094242 Major pelvis structure - 4229753 Region of esophagus - 4075991 Stomach - 4288283 Duodenal structure - 4302112 Jejunal structure - 4065077 Stricture of ileum - 4316356 Colon structure - 4215634 Rectum structure - 4144541 Mesentery - 4233095

                                                                                                                                                                                                                                                                                            Control1..1
                                                                                                                                                                                                                                                                                            TypeCodeableConcept
                                                                                                                                                                                                                                                                                            Obligations
                                                                                                                                                                                                                                                                                              ObligationsActor
                                                                                                                                                                                                                                                                                              SHALL:handle
                                                                                                                                                                                                                                                                                              98. CancerEpisode.subsites.intraThoracicSubsite
                                                                                                                                                                                                                                                                                              Definition

                                                                                                                                                                                                                                                                                              Specifies the subsite for cancers occurred in

                                                                                                                                                                                                                                                                                              ShortIntra thoracic subsite
                                                                                                                                                                                                                                                                                              Comments

                                                                                                                                                                                                                                                                                              Lung Heart Pleura Mediastinum Great vessels (please select: superior vena cava, aorta, pulmonary vessels, subclavian vessels, others)

                                                                                                                                                                                                                                                                                              Lung structure - 4213162 Heart structure - 4217142 Pleura structure - 4150673 Region of mediastinum - 4088610 Great vessels (please select: superior vena cava, aorta, pulmonary vessels, subclavian vessels, others) Superior vena cava structure - 4167648 Aorta part - 4001033 Stricture of pulmonary vessel - 4035327 Structure of subclavian artery - 4272388 Other - WILDCARD

                                                                                                                                                                                                                                                                                              Control1..1
                                                                                                                                                                                                                                                                                              TypeCodeableConcept
                                                                                                                                                                                                                                                                                              Obligations
                                                                                                                                                                                                                                                                                                ObligationsActor
                                                                                                                                                                                                                                                                                                SHALL:handle
                                                                                                                                                                                                                                                                                                100. CancerEpisode.subsites.genitoUrinarySubsite
                                                                                                                                                                                                                                                                                                Definition

                                                                                                                                                                                                                                                                                                Specifies the subsite for cancers occurred in

                                                                                                                                                                                                                                                                                                ShortGenito urinary subsite
                                                                                                                                                                                                                                                                                                Comments

                                                                                                                                                                                                                                                                                                Adrenal glands Kidney Urether Bladder Prostate Seminal Vescicle Spermatic Cord Testis Penis Utero Ovary Fallopian tube Vagina Vulva

                                                                                                                                                                                                                                                                                                Bilateral adrenal glands - 4047078 Kidney structure - 4271678 Region of ureter - 4078617 Urinary bladder structure - 4232481 Structure of lobe of prostate - 4034365 Seminal Vescicle structure - 4277442 Spermatic Cord structure - 4172591 Testis structure - 4238088 Penile structure - 4077311 Uterine structure - 4149192 Ovarian structure - 4049448 Fallopian tube structure - 4151444 Vaginal structure - 4296022 Vulval structure - 4166066

                                                                                                                                                                                                                                                                                                Control1..1
                                                                                                                                                                                                                                                                                                TypeCodeableConcept
                                                                                                                                                                                                                                                                                                Obligations
                                                                                                                                                                                                                                                                                                  ObligationsActor
                                                                                                                                                                                                                                                                                                  SHALL:handle
                                                                                                                                                                                                                                                                                                  102. CancerEpisode.subsites.headAndNeckSubsite
                                                                                                                                                                                                                                                                                                  Definition

                                                                                                                                                                                                                                                                                                  Specifies the subsite for cancers occurred in

                                                                                                                                                                                                                                                                                                  ShortHead and Neck subsite
                                                                                                                                                                                                                                                                                                  Comments

                                                                                                                                                                                                                                                                                                  Head and neck Face and/or neck structure - 4122633

                                                                                                                                                                                                                                                                                                  Control1..1
                                                                                                                                                                                                                                                                                                  TypeCodeableConcept
                                                                                                                                                                                                                                                                                                  Obligations
                                                                                                                                                                                                                                                                                                    ObligationsActor
                                                                                                                                                                                                                                                                                                    SHALL:handle
                                                                                                                                                                                                                                                                                                    104. CancerEpisode.subsites.breast
                                                                                                                                                                                                                                                                                                    Definition

                                                                                                                                                                                                                                                                                                    Specifies the subsite for cancers occurred in

                                                                                                                                                                                                                                                                                                    ShortBreast subsite
                                                                                                                                                                                                                                                                                                    Comments

                                                                                                                                                                                                                                                                                                    Breast Breast structure - 4298444

                                                                                                                                                                                                                                                                                                    Control1..1
                                                                                                                                                                                                                                                                                                    TypeCodeableConcept
                                                                                                                                                                                                                                                                                                    Obligations
                                                                                                                                                                                                                                                                                                      ObligationsActor
                                                                                                                                                                                                                                                                                                      SHALL:handle
                                                                                                                                                                                                                                                                                                      106. CancerEpisode.subsites.others
                                                                                                                                                                                                                                                                                                      Definition

                                                                                                                                                                                                                                                                                                      Specifies the subsite for cancers occurred in

                                                                                                                                                                                                                                                                                                      ShortOther subsite
                                                                                                                                                                                                                                                                                                      Control1..1
                                                                                                                                                                                                                                                                                                      TypeCodeableConcept
                                                                                                                                                                                                                                                                                                      Obligations
                                                                                                                                                                                                                                                                                                        ObligationsActor
                                                                                                                                                                                                                                                                                                        SHALL:handle
                                                                                                                                                                                                                                                                                                        108. CancerEpisode.tumorSize
                                                                                                                                                                                                                                                                                                        Definition

                                                                                                                                                                                                                                                                                                        (the longest diameter; longest dimension between pre operatory imaging and pathological specimen) cm

                                                                                                                                                                                                                                                                                                        ShortTumor Size
                                                                                                                                                                                                                                                                                                        Control1..1
                                                                                                                                                                                                                                                                                                        TypeQuantity
                                                                                                                                                                                                                                                                                                        Obligations
                                                                                                                                                                                                                                                                                                          ObligationsActor
                                                                                                                                                                                                                                                                                                          SHALL:handle
                                                                                                                                                                                                                                                                                                          110. CancerEpisode.depth
                                                                                                                                                                                                                                                                                                          Definition

                                                                                                                                                                                                                                                                                                          (for upper and lower limbs and superficial trunk) superficial (superficial tumour is located exclusively above the investing fascia without invasion of the fascia), deep (deep tumour is located beneath or invade the investing fascia). All the others are deep by definition

                                                                                                                                                                                                                                                                                                          ShortDepth
                                                                                                                                                                                                                                                                                                          Control1..1
                                                                                                                                                                                                                                                                                                          TypeCodeableConcept
                                                                                                                                                                                                                                                                                                          Obligations
                                                                                                                                                                                                                                                                                                            ObligationsActor
                                                                                                                                                                                                                                                                                                            SHALL:handle
                                                                                                                                                                                                                                                                                                            112. CancerEpisode.biopsyMitoticCount
                                                                                                                                                                                                                                                                                                            Definition

                                                                                                                                                                                                                                                                                                            (Number/10HPF/1mm2, 50HPF/5mm2)

                                                                                                                                                                                                                                                                                                            ShortBiopsy Mitotic count
                                                                                                                                                                                                                                                                                                            Control1..1
                                                                                                                                                                                                                                                                                                            TypeQuantity
                                                                                                                                                                                                                                                                                                            Obligations
                                                                                                                                                                                                                                                                                                              ObligationsActor
                                                                                                                                                                                                                                                                                                              SHALL:handle
                                                                                                                                                                                                                                                                                                              114. CancerEpisode.plasmaticEbvDnaAtBaseline
                                                                                                                                                                                                                                                                                                              Definition

                                                                                                                                                                                                                                                                                                              Describes the result of EBV DNA plasma testing before treatment in NPC type II and III (WHO)

                                                                                                                                                                                                                                                                                                              ShortPlasmatic EBV DNA at baseline
                                                                                                                                                                                                                                                                                                              Comments

                                                                                                                                                                                                                                                                                                              Positive; Negative; not tested; Positive - 9191 Negative - 9189 not tested - 45878602

                                                                                                                                                                                                                                                                                                              Control0..1
                                                                                                                                                                                                                                                                                                              TypeCodeableConcept
                                                                                                                                                                                                                                                                                                              Obligations
                                                                                                                                                                                                                                                                                                                ObligationsActor
                                                                                                                                                                                                                                                                                                                SHALL:handle
                                                                                                                                                                                                                                                                                                                116. CancerEpisode.hpvStatus
                                                                                                                                                                                                                                                                                                                Definition

                                                                                                                                                                                                                                                                                                                Describes the result of HPV tumor testing in oral carcinoma

                                                                                                                                                                                                                                                                                                                ShortHPV status
                                                                                                                                                                                                                                                                                                                Comments

                                                                                                                                                                                                                                                                                                                Positive; Negative; Not tested; Positive - 9191 Negative - 9189 not tested - 45878602

                                                                                                                                                                                                                                                                                                                Control0..1
                                                                                                                                                                                                                                                                                                                TypeCodeableConcept
                                                                                                                                                                                                                                                                                                                Obligations
                                                                                                                                                                                                                                                                                                                  ObligationsActor
                                                                                                                                                                                                                                                                                                                  SHALL:handle
                                                                                                                                                                                                                                                                                                                  118. CancerEpisode.crpCReactiveProteinTested
                                                                                                                                                                                                                                                                                                                  Definition

                                                                                                                                                                                                                                                                                                                  Describes the result of C reactive protein testing

                                                                                                                                                                                                                                                                                                                  ShortCRP - C reactive protein tested
                                                                                                                                                                                                                                                                                                                  Comments

                                                                                                                                                                                                                                                                                                                  Positive; Negative; Not tested; Positive - 9191 Negative - 9189 not tested - 45878602

                                                                                                                                                                                                                                                                                                                  Control0..1
                                                                                                                                                                                                                                                                                                                  TypeCodeableConcept
                                                                                                                                                                                                                                                                                                                  Obligations
                                                                                                                                                                                                                                                                                                                    ObligationsActor
                                                                                                                                                                                                                                                                                                                    SHALL:handle