Lithuanian Laboratory Implementation Guide, published by Lithuanian Medical Library. This guide is not an authorized publication; it is the continuous build for version 0.0.1 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7LT/ig-lt-lab/ and changes regularly. See the Directory of published versions

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: HER2 FISH/CISH/SISH Result Classification

Draft as of 2026-03-29

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{
  "resourceType" : "CodeSystem",
  "id" : "her2-fish-result",
  "language" : "en",
  "text" : {
    "status" : "generated",
    "div" : "<div xml:lang=\"en\" lang=\"en\"><hr/><p><b>English</b></p><hr/><p class=\"res-header-id\"><b>Generated Narrative: CodeSystem her2-fish-result</b></p><a name=\"her2-fish-result\"> </a><a name=\"hcher2-fish-result\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Language: en</p></div><p>This case-sensitive code system <code>https://tx.hl7.lt/fhir/CodeSystem/her2-fish-result</code> defines the following codes:</p><table class=\"codes\"><tr><td style=\"white-space:nowrap\"><b>Code</b></td><td><b>Display</b></td></tr><tr><td style=\"white-space:nowrap\">amplified<a name=\"her2-fish-result-amplified\"> </a></td><td>Amplified (HER2&gt;=4, HER2/CEP17&gt;=2)</td></tr><tr><td style=\"white-space:nowrap\">amplified-clusters<a name=\"her2-fish-result-amplified-clusters\"> </a></td><td>Amplified (clusters)</td></tr><tr><td style=\"white-space:nowrap\">co-amplified<a name=\"her2-fish-result-co-amplified\"> </a></td><td>Co-amplified (HER2&gt;=6, HER2/CEP17&lt;2)</td></tr><tr><td style=\"white-space:nowrap\">borderline<a name=\"her2-fish-result-borderline\"> </a></td><td>Borderline (4&lt;=HER2&lt;6, HER2/CEP17&lt;2)</td></tr><tr><td style=\"white-space:nowrap\">monosomic<a name=\"her2-fish-result-monosomic\"> </a></td><td>Monosomic (HER2&lt;4, HER2/CEP17&gt;=2)</td></tr><tr><td style=\"white-space:nowrap\">negative<a name=\"her2-fish-result-negative\"> </a></td><td>Negative (HER2&lt;4, HER2/CEP17&lt;2)</td></tr><tr><td style=\"white-space:nowrap\">not-evaluated<a name=\"her2-fish-result-not-evaluated\"> </a></td><td>Not to be evaluated</td></tr></table></div>"
  },
  "url" : "https://tx.hl7.lt/fhir/CodeSystem/her2-fish-result",
  "version" : "0.0.1",
  "name" : "Her2FishResultLtLab",
  "title" : "HER2 FISH/CISH/SISH Result Classification",
  "status" : "draft",
  "experimental" : true,
  "date" : "2026-03-29T11:59:27+00:00",
  "publisher" : "Lithuanian Medical Library",
  "contact" : [
    {
      "name" : "Lithuanian Medical Library",
      "telecom" : [
        {
          "system" : "url",
          "value" : "https://medicinosnk.lt"
        },
        {
          "system" : "email",
          "value" : "info@medicinosnk.lt"
        }
      ]
    }
  ],
  "description" : "Classification of HER2 gene amplification results from FISH, CISH, or SISH molecular testing.",
  "jurisdiction" : [
    {
      "coding" : [
        {
          "system" : "urn:iso:std:iso:3166",
          "code" : "LT"
        }
      ]
    }
  ],
  "caseSensitive" : true,
  "content" : "complete",
  "count" : 7,
  "concept" : [
    {
      "code" : "amplified",
      "display" : "Amplified (HER2>=4, HER2/CEP17>=2)"
    },
    {
      "code" : "amplified-clusters",
      "display" : "Amplified (clusters)"
    },
    {
      "code" : "co-amplified",
      "display" : "Co-amplified (HER2>=6, HER2/CEP17<2)"
    },
    {
      "code" : "borderline",
      "display" : "Borderline (4<=HER2<6, HER2/CEP17<2)"
    },
    {
      "code" : "monosomic",
      "display" : "Monosomic (HER2<4, HER2/CEP17>=2)"
    },
    {
      "code" : "negative",
      "display" : "Negative (HER2<4, HER2/CEP17<2)"
    },
    {
      "code" : "not-evaluated",
      "display" : "Not to be evaluated"
    }
  ]
}