Molecular Definition Implementation Guide for Molecular Data Types
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Molecular Definition Implementation Guide for Molecular Data Types, published by HL7 International / Clinical Genomics. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot1 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/molecular-definition-data-types/ and changes regularly. See the Directory of published versions

: Nucleotide DNA Symbols - JSON Representation

Page standards status: Draft Maturity Level: 0

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{
  "resourceType" : "CodeSystem",
  "id" : "nucleotide-dna",
  "text" : {
    "status" : "generated",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: CodeSystem nucleotide-dna</b></p><a name=\"nucleotide-dna\"> </a><a name=\"hcnucleotide-dna\"> </a><p>This case-sensitive code system <code>http://hl7.org/fhir/uv/molecular-definition-data-types/CodeSystem/nucleotide-dna</code> defines the following codes:</p><table class=\"codes\"><tr><td style=\"white-space:nowrap\"><b>Code</b></td><td><b>Display</b></td><td><b>Definition</b></td></tr><tr><td style=\"white-space:nowrap\">G<a name=\"nucleotide-dna-G\"> </a></td><td>Guanine</td><td>G</td></tr><tr><td style=\"white-space:nowrap\">A<a name=\"nucleotide-dna-A\"> </a></td><td>Adenine</td><td>A</td></tr><tr><td style=\"white-space:nowrap\">T<a name=\"nucleotide-dna-T\"> </a></td><td>Thymine</td><td>T</td></tr><tr><td style=\"white-space:nowrap\">C<a name=\"nucleotide-dna-C\"> </a></td><td>Cytosine</td><td>C</td></tr><tr><td style=\"white-space:nowrap\">R<a name=\"nucleotide-dna-R\"> </a></td><td>Purine</td><td>G or A</td></tr><tr><td style=\"white-space:nowrap\">Y<a name=\"nucleotide-dna-Y\"> </a></td><td>Pyrimidine</td><td>T or C</td></tr><tr><td style=\"white-space:nowrap\">M<a name=\"nucleotide-dna-M\"> </a></td><td>Amino</td><td>A or C</td></tr><tr><td style=\"white-space:nowrap\">K<a name=\"nucleotide-dna-K\"> </a></td><td>Keto</td><td>G or T</td></tr><tr><td style=\"white-space:nowrap\">S<a name=\"nucleotide-dna-S\"> </a></td><td>Strong interaction (3 H bonds)</td><td>G or C</td></tr><tr><td style=\"white-space:nowrap\">W<a name=\"nucleotide-dna-W\"> </a></td><td>Weak interaction (2 H bonds)</td><td>A or T</td></tr><tr><td style=\"white-space:nowrap\">H<a name=\"nucleotide-dna-H\"> </a></td><td>not-G, H follows G in the alphabet</td><td>A or C or T</td></tr><tr><td style=\"white-space:nowrap\">B<a name=\"nucleotide-dna-B\"> </a></td><td>not-A, B follows A</td><td>G or T or C</td></tr><tr><td style=\"white-space:nowrap\">V<a name=\"nucleotide-dna-V\"> </a></td><td>not-T (not-U), V follows U</td><td>G or C or A</td></tr><tr><td style=\"white-space:nowrap\">D<a name=\"nucleotide-dna-D\"> </a></td><td>not-C, D follows C</td><td>G or A or T</td></tr><tr><td style=\"white-space:nowrap\">N<a name=\"nucleotide-dna-N\"> </a></td><td>Any nucleotide</td><td>G or A or T or C</td></tr></table></div>"
  },
  "extension" : [
    {
      "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-wg",
      "valueCode" : "cg"
    },
    {
      "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-fmm",
      "valueInteger" : 0,
      "_valueInteger" : {
        "extension" : [
          {
            "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-conformance-derivedFrom",
            "valueCanonical" : "http://hl7.org/fhir/uv/molecular-definition-data-types/ImplementationGuide/hl7.fhir.uv.molecular-definition-data-types"
          }
        ]
      }
    },
    {
      "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-standards-status",
      "valueCode" : "draft",
      "_valueCode" : {
        "extension" : [
          {
            "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-conformance-derivedFrom",
            "valueCanonical" : "http://hl7.org/fhir/uv/molecular-definition-data-types/ImplementationGuide/hl7.fhir.uv.molecular-definition-data-types"
          }
        ]
      }
    }
  ],
  "url" : "http://hl7.org/fhir/uv/molecular-definition-data-types/CodeSystem/nucleotide-dna",
  "version" : "1.0.0-ballot1",
  "name" : "NucleotideDNA",
  "title" : "Nucleotide DNA Symbols",
  "status" : "draft",
  "experimental" : false,
  "date" : "2025-09-26T21:26:20+00:00",
  "publisher" : "HL7 International / Clinical Genomics",
  "contact" : [
    {
      "name" : "HL7 International / Clinical Genomics",
      "telecom" : [
        {
          "system" : "url",
          "value" : "http://www.hl7.org/Special/committees/clingenomics"
        },
        {
          "system" : "email",
          "value" : "cg@lists.HL7.org"
        }
      ]
    }
  ],
  "description" : "Single-letter symbols for DNA residues, including unambiguous, ambiguous, and N symbols.",
  "jurisdiction" : [
    {
      "coding" : [
        {
          "system" : "http://unstats.un.org/unsd/methods/m49/m49.htm",
          "code" : "001",
          "display" : "World"
        }
      ]
    }
  ],
  "caseSensitive" : true,
  "content" : "complete",
  "count" : 15,
  "concept" : [
    {
      "code" : "G",
      "display" : "Guanine",
      "definition" : "G"
    },
    {
      "code" : "A",
      "display" : "Adenine",
      "definition" : "A"
    },
    {
      "code" : "T",
      "display" : "Thymine",
      "definition" : "T"
    },
    {
      "code" : "C",
      "display" : "Cytosine",
      "definition" : "C"
    },
    {
      "code" : "R",
      "display" : "Purine",
      "definition" : "G or A"
    },
    {
      "code" : "Y",
      "display" : "Pyrimidine",
      "definition" : "T or C"
    },
    {
      "code" : "M",
      "display" : "Amino",
      "definition" : "A or C"
    },
    {
      "code" : "K",
      "display" : "Keto",
      "definition" : "G or T"
    },
    {
      "code" : "S",
      "display" : "Strong interaction (3 H bonds)",
      "definition" : "G or C"
    },
    {
      "code" : "W",
      "display" : "Weak interaction (2 H bonds)",
      "definition" : "A or T"
    },
    {
      "code" : "H",
      "display" : "not-G, H follows G in the alphabet",
      "definition" : "A or C or T"
    },
    {
      "code" : "B",
      "display" : "not-A, B follows A",
      "definition" : "G or T or C"
    },
    {
      "code" : "V",
      "display" : "not-T (not-U), V follows U",
      "definition" : "G or C or A"
    },
    {
      "code" : "D",
      "display" : "not-C, D follows C",
      "definition" : "G or A or T"
    },
    {
      "code" : "N",
      "display" : "Any nucleotide",
      "definition" : "G or A or T or C"
    }
  ]
}