Global Core Electronic Medicinal Product Information (ePI), published by HL7 International / Biomedical Research and Regulation. This guide is not an authorized publication; it is the continuous build for version 1.1.0 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/emedicinal-product-info/ and changes regularly. See the Directory of published versions

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: ClinicalUseDefinition - Warning Renal Dose Adjustment

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<ClinicalUseDefinition xmlns="http://hl7.org/fhir">
  <id value="cud-diflucan-renal"/>
  <meta>
    <profile
             value="http://hl7.org/fhir/uv/emedicinal-product-info/StructureDefinition/ClinicalUseDefinition-warning-uv-epi"/>
  </meta>
  <language value="en"/>
  <text>
    <status value="generated"/>
    <div xmlns="http://www.w3.org/1999/xhtml"><p class="res-header-id"><b>Generated Narrative: ClinicalUseDefinition cud-diflucan-renal</b></p><a name="cud-diflucan-renal"> </a><a name="hccud-diflucan-renal"> </a><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px"/><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-ClinicalUseDefinition-warning-uv-epi.html">ClinicalUseDefinition Warning (ePI)</a></p></div><p><b>identifier</b>: <code>http://example.org/identifier</code>/cud-diflucan-renal</p><p><b>type</b>: Warning</p><p><b>category</b>: <span title="Codes:{http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-ig warning}">Warning</span></p><p><b>subject</b>: <a href="Bundle-bundle-epi-type3-example-diflucan.html#http-//hl7.org/fhir/uv/emedicinal-product-info/MedicinalProductDefinition/mpd-diflucan">MedicinalProductDefinition: identifier = http://ema.europa.eu/identifier#DIFLUCAN-150MG; status = Active</a></p><p><b>status</b>: <span title="Codes:{http://hl7.org/fhir/publication-status active}">Active</span></p><p><b>population</b>: <a href="Group-group-diflucan-renal.html">Renal impairment (CrCl ≤ 50 mL/min)</a></p><h3>Warnings</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://snomed.info/sct 723188008}">For multiple-dose therapy, after a normal loading dose, give 50% of the recommended daily dose when CrCl ≤ 50 mL/min (no haemodialysis); give 100% of the recommended dose after each haemodialysis session. Single-dose therapy needs no adjustment. This rule applies to every multiple-dose indication.</span></td></tr></table></div>
  </text>
  <identifier>
    <system value="http://example.org/identifier"/>
    <value value="cud-diflucan-renal"/>
  </identifier>
  <type value="warning"/>
  <category>
    <coding>
      <system
              value="http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-ig"/>
      <code value="warning"/>
      <display value="Warning"/>
    </coding>
  </category>
  <subject>🔗 
    <reference
               value="http://hl7.org/fhir/uv/emedicinal-product-info/MedicinalProductDefinition/mpd-diflucan"/>
  </subject>
  <status>
    <coding>
      <system value="http://hl7.org/fhir/publication-status"/>
      <code value="active"/>
      <display value="Active"/>
    </coding>
  </status>
  <population>🔗 
    <reference value="Group/group-diflucan-renal"/>
    <display value="Renal impairment (CrCl ≤ 50 mL/min)"/>
  </population>
  <warning>
    <code>
      <coding>
        <system value="http://snomed.info/sct"/>
        <code value="723188008"/>
        <display value="Renal insufficiency"/>
      </coding>
      <text
            value="For multiple-dose therapy, after a normal loading dose, give 50% of the recommended daily dose when CrCl ≤ 50 mL/min (no haemodialysis); give 100% of the recommended dose after each haemodialysis session. Single-dose therapy needs no adjustment. This rule applies to every multiple-dose indication."/>
    </code>
  </warning>
</ClinicalUseDefinition>