Global Core Electronic Medicinal Product Information (ePI)
1.1.0 - trial-use World

Global Core Electronic Medicinal Product Information (ePI), published by HL7 International / Biomedical Research and Regulation. This guide is not an authorized publication; it is the continuous build for version 1.1.0 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/emedicinal-product-info/ and changes regularly. See the Directory of published versions

: ClinicalUseDefinition - Warning Renal Dose Adjustment

Page standards status: Informative

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@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix sct: <http://snomed.info/id/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

<http://hl7.org/fhir/ClinicalUseDefinition/cud-diflucan-renal> a fhir:ClinicalUseDefinition ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "cud-diflucan-renal"] ; # 
  fhir:meta [
     fhir:profile ( [
       fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/StructureDefinition/ClinicalUseDefinition-warning-uv-epi"^^xsd:anyURI ;
       fhir:link <http://hl7.org/fhir/uv/emedicinal-product-info/StructureDefinition/ClinicalUseDefinition-warning-uv-epi>
     ] )
  ] ; # 
  fhir:language [ fhir:v "en"] ; # 
  fhir:text [
     fhir:status [ fhir:v "generated" ] ;
     fhir:div [ fhir:v "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: ClinicalUseDefinition cud-diflucan-renal</b></p><a name=\"cud-diflucan-renal\"> </a><a name=\"hccud-diflucan-renal\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-ClinicalUseDefinition-warning-uv-epi.html\">ClinicalUseDefinition Warning (ePI)</a></p></div><p><b>identifier</b>: <code>http://example.org/identifier</code>/cud-diflucan-renal</p><p><b>type</b>: Warning</p><p><b>category</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-ig warning}\">Warning</span></p><p><b>subject</b>: <a href=\"Bundle-bundle-epi-type3-example-diflucan.html#http-//hl7.org/fhir/uv/emedicinal-product-info/MedicinalProductDefinition/mpd-diflucan\">MedicinalProductDefinition: identifier = http://ema.europa.eu/identifier#DIFLUCAN-150MG; status = Active</a></p><p><b>status</b>: <span title=\"Codes:{http://hl7.org/fhir/publication-status active}\">Active</span></p><p><b>population</b>: <a href=\"Group-group-diflucan-renal.html\">Renal impairment (CrCl ≤ 50 mL/min)</a></p><h3>Warnings</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 723188008}\">For multiple-dose therapy, after a normal loading dose, give 50% of the recommended daily dose when CrCl ≤ 50 mL/min (no haemodialysis); give 100% of the recommended dose after each haemodialysis session. Single-dose therapy needs no adjustment. This rule applies to every multiple-dose indication.</span></td></tr></table></div>"^^rdf:XMLLiteral ]
  ] ; # 
  fhir:identifier ( [
     fhir:system [ fhir:v "http://example.org/identifier"^^xsd:anyURI ] ;
     fhir:value [ fhir:v "cud-diflucan-renal" ]
  ] ) ; # 
  fhir:type [ fhir:v "warning"] ; # 
  fhir:category ( [
     fhir:coding ( [
       fhir:system [ fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-ig"^^xsd:anyURI ] ;
       fhir:code [ fhir:v "warning" ] ;
       fhir:display [ fhir:v "Warning" ]
     ] )
  ] ) ; # 
  fhir:subject ( [
     fhir:link <http://hl7.org/fhir/uv/emedicinal-product-info/MedicinalProductDefinition/mpd-diflucan> ;
     fhir:reference [ fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/MedicinalProductDefinition/mpd-diflucan" ]
  ] ) ; # 
  fhir:status [
     fhir:coding ( [
       fhir:system [ fhir:v "http://hl7.org/fhir/publication-status"^^xsd:anyURI ] ;
       fhir:code [ fhir:v "active" ] ;
       fhir:display [ fhir:v "Active" ]
     ] )
  ] ; # 
  fhir:population ( [
     fhir:link <http://hl7.org/fhir/Group/group-diflucan-renal> ;
     fhir:reference [ fhir:v "Group/group-diflucan-renal" ] ;
     fhir:display [ fhir:v "Renal impairment (CrCl ≤ 50 mL/min)" ]
  ] ) ; # 
  fhir:warning [
     fhir:code [
       fhir:coding ( [
         a sct:723188008 ;
         fhir:system [ fhir:v "http://snomed.info/sct"^^xsd:anyURI ] ;
         fhir:code [ fhir:v "723188008" ] ;
         fhir:display [ fhir:v "Renal insufficiency" ]
       ] ) ;
       fhir:text [ fhir:v "For multiple-dose therapy, after a normal loading dose, give 50% of the recommended daily dose when CrCl ≤ 50 mL/min (no haemodialysis); give 100% of the recommended dose after each haemodialysis session. Single-dose therapy needs no adjustment. This rule applies to every multiple-dose indication." ]
     ]
  ] . # 

<http://hl7.org/fhir/uv/emedicinal-product-info/MedicinalProductDefinition/mpd-diflucan> a fhir:uv .

<http://hl7.org/fhir/Group/group-diflucan-renal> a fhir:Group .