Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot3 - STU 1 Ballot 3 World

Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot3 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions

: PICO: Intensive versus standard blood-pressure control for major adverse cardiovascular events in adults at increased cardiovascular risk

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@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix sct: <http://snomed.info/id/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

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     fhir:div [ fhir:v "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: Group 588218</b></p><a name=\"588218\"> </a><a name=\"hc588218\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">version: 7; Last updated: 2026-08-15 16:32:10+0000</p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-pico-specification.html\">PICOSpecification</a></p></div><p><b>Artifact Author</b>: Khalid Shahin: </p><p><b>ArtifactRecorder</b>: Khalid Shahin: </p><p><b>CiteAs</b>: </p><div><p>PICO: Intensive versus standard blood-pressure control for major adverse cardiovascular events in adults at increased cardiovascular risk [Database Entry: FHIR Group Resource]. Contributors: Khalid Shahin [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 588218. Revised 2026-08-15. Available at: https://fevir.net/resources/Group/588218. Computable resource at: https://fevir.net/resources/Group/588218#json.</p>\n</div><p><b>ArtifactPublicationStatus</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-status-type active}\">Active</span></p><p><b>url</b>: <a href=\"https://fevir.net/resources/Group/588218\">https://fevir.net/resources/Group/588218</a></p><p><b>identifier</b>: FEvIR Object Identifier/588218, <code>http://example.org/fhir/sid/pico-register</code>/PICO-2026-0142 (use: official, )</p><p><b>title</b>: PICO: Intensive versus standard blood-pressure control for major adverse cardiovascular events in adults at increased cardiovascular risk</p><p><b>status</b>: Active</p><p><b>publisher</b>: Computable Publishing LLC</p><p><b>contact</b>: <a href=\"mailto:support@computablepublishing.com\">support@computablepublishing.com</a></p><p><b>description</b>: </p><div><p>This Group Resource is referenced in an example for the EBMonFHIR Implementation Guide.</p>\n</div><p><b>copyright</b>: </p><div><p>Copyright the Authors else Computable Publishing LLC. Noncommercial use permitted with CC BY-NC-SA 4.0 (https://creativecommons.org/licenses/by-nc-sa/4.0/). Commercial use permitted as agreed in Terms of Use (https://fevir.net/termsofuse).</p>\n</div><p><b>membership</b>: Conceptual</p><p><b>combinationMethod</b>: All of</p><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes:{https://fevir.net/resources/CodeSystem/179423 population}\">Population</span></p><p><b>value</b>: <span title=\"Codes:{http://snomed.info/sct 38341003}\">Hypertension with systolic blood pressure 130-180 mmHg and at least one additional cardiovascular risk factor</span></p><p><b>exclude</b>: false</p><p><b>description</b>: </p><div><p>Adults with a measured systolic blood pressure between 130 and 180 mmHg inclusive, together with at least one of: clinical or subclinical cardiovascular disease, chronic kidney disease with eGFR 20-59 mL/min/1.73 m2, a 10-year Framingham risk score of 15 percent or greater, or age 75 years or older.</p>\n</div></blockquote><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/usage-context-type age}\">Age Range</span></p><p><b>value</b>: 50-? years</p><p><b>exclude</b>: false</p><p><b>description</b>: </p><div><p>Aged 50 years or older at the time of eligibility assessment. No upper age limit is applied.</p>\n</div></blockquote><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes:{https://fevir.net/resources/CodeSystem/179423 intervention}\">Intervention</span></p><p><b>value</b>: <span title=\"Codes:\">Intensive blood-pressure control: antihypertensive therapy titrated to a systolic target below 120 mmHg</span></p><p><b>exclude</b>: false</p><p><b>description</b>: </p><div><p>Any antihypertensive regimen titrated at monthly intervals to achieve and maintain a systolic blood pressure below 120 mmHg. The specific agents used are not constrained by this question.</p>\n</div></blockquote><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes:{https://fevir.net/resources/CodeSystem/179423 comparator}\">Comparator</span></p><p><b>value</b>: <span title=\"Codes:\">Standard blood-pressure control: antihypertensive therapy titrated to a systolic target below 140 mmHg</span></p><p><b>exclude</b>: false</p><p><b>description</b>: </p><div><p>Any antihypertensive regimen titrated to achieve and maintain a systolic blood pressure below 140 mmHg, reflecting the guideline-recommended target in force at the time the question was formulated.</p>\n</div></blockquote><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes:{https://fevir.net/resources/CodeSystem/179423 outcome-measure}\">Outcome Measure</span></p><p><b>value</b>: <span title=\"Codes:\">Major adverse cardiovascular events: composite of myocardial infarction, other acute coronary syndrome, stroke, acute decompensated heart failure, or death from cardiovascular causes</span></p><p><b>exclude</b>: false</p><p><b>description</b>: </p><div><p>Time to first occurrence of any component of the composite, adjudicated by a committee unaware of treatment assignment. Individual components are reported as separate outcome measures in the evidence report.</p>\n</div><h3>RelativeTimes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Offset[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>No display for Duration  (value: 5; unit: years; system: http://unitsofmeasure.org; code: a)</td></tr></table></blockquote></div>"^^rdf:XMLLiteral ]
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