Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot3 - STU 1 Ballot 3 World

Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot3 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions

Example Group: PICO: Intensive versus standard blood-pressure control for major adverse cardiovascular events in adults at increased cardiovascular risk

version: 7; Last updated: 2026-08-15 16:32:10+0000

Profile: PICOSpecification

Artifact Author: Khalid Shahin:

ArtifactRecorder: Khalid Shahin:

CiteAs:

PICO: Intensive versus standard blood-pressure control for major adverse cardiovascular events in adults at increased cardiovascular risk [Database Entry: FHIR Group Resource]. Contributors: Khalid Shahin [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 588218. Revised 2026-08-15. Available at: https://fevir.net/resources/Group/588218. Computable resource at: https://fevir.net/resources/Group/588218#json.

ArtifactPublicationStatus: Active

url: https://fevir.net/resources/Group/588218

identifier: FEvIR Object Identifier/588218, http://example.org/fhir/sid/pico-register/PICO-2026-0142 (use: official, )

title: PICO: Intensive versus standard blood-pressure control for major adverse cardiovascular events in adults at increased cardiovascular risk

status: Active

publisher: Computable Publishing LLC

contact: support@computablepublishing.com

description:

This Group Resource is referenced in an example for the EBMonFHIR Implementation Guide.

copyright:

Copyright the Authors else Computable Publishing LLC. Noncommercial use permitted with CC BY-NC-SA 4.0 (https://creativecommons.org/licenses/by-nc-sa/4.0/). Commercial use permitted as agreed in Terms of Use (https://fevir.net/termsofuse).

membership: Conceptual

combinationMethod: All of

characteristic

code: Population

value: Hypertension with systolic blood pressure 130-180 mmHg and at least one additional cardiovascular risk factor

exclude: false

description:

Adults with a measured systolic blood pressure between 130 and 180 mmHg inclusive, together with at least one of: clinical or subclinical cardiovascular disease, chronic kidney disease with eGFR 20-59 mL/min/1.73 m2, a 10-year Framingham risk score of 15 percent or greater, or age 75 years or older.

characteristic

code: Age Range

value: 50-? years

exclude: false

description:

Aged 50 years or older at the time of eligibility assessment. No upper age limit is applied.

characteristic

code: Intervention

value: Intensive blood-pressure control: antihypertensive therapy titrated to a systolic target below 120 mmHg

exclude: false

description:

Any antihypertensive regimen titrated at monthly intervals to achieve and maintain a systolic blood pressure below 120 mmHg. The specific agents used are not constrained by this question.

characteristic

code: Comparator

value: Standard blood-pressure control: antihypertensive therapy titrated to a systolic target below 140 mmHg

exclude: false

description:

Any antihypertensive regimen titrated to achieve and maintain a systolic blood pressure below 140 mmHg, reflecting the guideline-recommended target in force at the time the question was formulated.

characteristic

code: Outcome Measure

value: Major adverse cardiovascular events: composite of myocardial infarction, other acute coronary syndrome, stroke, acute decompensated heart failure, or death from cardiovascular causes

exclude: false

description:

Time to first occurrence of any component of the composite, adjudicated by a committee unaware of treatment assignment. Individual components are reported as separate outcome measures in the evidence report.

RelativeTimes

-Offset[x]
*No display for Duration (value: 5; unit: years; system: http://unitsofmeasure.org; code: a)