Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot3 - STU 1 Ballot 3 World

Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot3 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions

: Example of statistical model expression

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<Evidence xmlns="http://hl7.org/fhir">
  <id value="587629"/>
  <meta>
    <versionId value="4"/>
    <lastUpdated value="2026-08-03T18:52:42.905Z"/>
    <profile
             value="http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model"/>
  </meta>
  <language value="en"/>
  <text>
    <status value="extensions"/>
    <div xmlns="http://www.w3.org/1999/xhtml"><p class="res-header-id"><b>Generated Narrative: Evidence 587629</b></p><a name="587629"> </a><a name="hc587629"> </a><div style="display: inline-block; background-color: #fbffeb; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">version: 4; Last updated: 2026-08-03 18:52:42+0000</p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-statistic-model.html">StatisticModel</a></p></div><p><b>ArtifactPublicationStatus</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-status-type active}">Active</span></p><p><b>url</b>: <a href="Evidence-587629.html">Evidence Example of statistical model expression</a></p><p><b>identifier</b>: FEvIR Object Identifier/587629, <a href="http://terminology.hl7.org/7.5.0/NamingSystem-uri.html" title="As defined by RFC 3986 (http://www.ietf.org/rfc/rfc3986.txt)(with many schemes defined in many RFCs). For OIDs and UUIDs, use the URN form (urn:oid:(note: lowercase) and urn:uuid:). See http://www.ietf.org/rfc/rfc3001.txt and http://www.ietf.org/rfc/rfc4122.txt 

This oid is used as an identifier II.root to indicate the the extension is an absolute URI (technically, an IRI). Typically, this is used for OIDs and GUIDs. Note that when this OID is used with OIDs and GUIDs, the II.extension should start with urn:oid or urn:uuid: 

Note that this OID is created to aid with interconversion between CDA and FHIR - FHIR uses urn:ietf:rfc:3986 as equivalent to this OID. URIs as identifiers appear more commonly in FHIR.

This OID may also be used in CD.codeSystem.">Uniform Resource Identifier (URI)</a>/urn:oid:2.16.840.1.113883.4.642.40.44.22.86</p><p><b>version</b>: 1.0.0-ballot3</p><p><b>name</b>: Example_of_statistical_model_expression</p><p><b>title</b>: Example of statistical model expression</p><p><b>citeAs</b>: </p><div><p>Example of statistical model expression [Database Entry: FHIR Evidence Resource]. Contributors: Brian S. Alper, MD, MSPH [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 587629. Revised 2026-08-03. Available at: https://fevir.net/resources/Evidence/587629. Computable resource at: https://fevir.net/resources/Evidence/587629#json.</p>
</div><p><b>status</b>: Active</p><p><b>date</b>: 2026-11-05 14:34:28+0000</p><p><b>author</b>: Brian S. Alper, MD, MSPH: </p><p><b>publisher</b>: HL7 International / Clinical Decision Support</p><p><b>contact</b>: HL7 International / Clinical Decision Support: <a href="http://www.hl7.org/Special/committees/dss">http://www.hl7.org/Special/committees/dss</a></p><p><b>copyright</b>: </p><div><p>Copyright the Authors else Computable Publishing LLC. Noncommercial use permitted with CC BY-NC-SA 4.0 (https://creativecommons.org/licenses/by-nc-sa/4.0/). Commercial use permitted as agreed in Terms of Use (https://fevir.net/termsofuse).</p>
</div><p><b>description</b>: </p><div><p>This is an example of madeup Evidence to demonstrate the StatisticalModelExpression extension.</p>
</div><blockquote><p><b>variableDefinition</b></p><p><b>description</b>: </p><div><p>Patients with diabetes</p>
</div><p><b>variableRole</b>: Population</p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>description</b>: </p><div><p>GroupAssignment: Treatment vs. Control</p>
</div><p><b>variableRole</b>: Exposure</p><p><b>comparatorCategory</b>: Control</p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>description</b>: </p><div><p>The primary outcome</p>
</div><p><b>variableRole</b>: Outcome</p></blockquote><blockquote><p><b>statistic</b></p><p><b>StatisticModelExpression</b>: <span title="text/r"><code>glm(Outcome ~ Treatment + Baseline_A1C + Age, family = binomial(link = 'logit'))</code></span>(&quot;Logistic regression formula used to calculate the adjusted odds ratio for the primary endpoint.&quot;)</p><p><b>description</b>: </p><div><p>Adjusted Odds Ratio for primary outcome 1.45 (95% CI .12 to 1.88)</p>
</div><p><b>statisticType</b>: <span title="Codes:{https://fevir.net/sevco STATO:0000182}">odds ratio</span></p><p><b>quantity</b>: 1.45</p><h3>AttributeEstimates</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Range</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://terminology.hl7.org/CodeSystem/attribute-estimate-type C53324}">Confidence interval</span></td><td>1.12-1.88</td></tr></table></blockquote></div>
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  <url value="https://fevir.net/resources/Evidence/587629"/>
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    <value value="urn:oid:2.16.840.1.113883.4.642.40.44.22.86"/>
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  <version value="1.0.0-ballot3"/>
  <name value="Example_of_statistical_model_expression"/>
  <title value="Example of statistical model expression"/>
  <citeAs
          value="Example of statistical model expression [Database Entry: FHIR Evidence Resource]. Contributors: Brian S. Alper, MD, MSPH [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 587629. Revised 2026-08-03. Available at: https://fevir.net/resources/Evidence/587629. Computable resource at: https://fevir.net/resources/Evidence/587629#json."/>
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  <description
               value="This is an example of madeup Evidence to demonstrate the StatisticalModelExpression extension."/>
  <variableDefinition>
    <description value="Patients with diabetes"/>
    <variableRole value="population"/>
  </variableDefinition>
  <variableDefinition>
    <description value="GroupAssignment: Treatment vs. Control"/>
    <variableRole value="exposure"/>
    <comparatorCategory value="Control"/>
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  <variableDefinition>
    <description value="The primary outcome"/>
    <variableRole value="outcome"/>
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               url="http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-expression">
      <valueExpression>
        <description
                     value="Logistic regression formula used to calculate the adjusted odds ratio for the primary endpoint."/>
        <language value="text/r"/>
        <expression
                    value="glm(Outcome ~ Treatment + Baseline_A1C + Age, family = binomial(link = 'logit'))"/>
      </valueExpression>
    </extension>
    <description
                 value="Adjusted Odds Ratio for primary outcome 1.45 (95% CI .12 to 1.88)"/>
    <statisticType>
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        <system value="https://fevir.net/sevco"/>
        <code value="STATO:0000182"/>
        <display value="odds ratio"/>
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    <quantity>
      <value value="1.45"/>
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    <attributeEstimate>
      <type>
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          <system
                  value="http://terminology.hl7.org/CodeSystem/attribute-estimate-type"/>
          <code value="C53324"/>
          <display value="Confidence interval"/>
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      <range>
        <low>
          <value value="1.12"/>
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        <high>
          <value value="1.88"/>
        </high>
      </range>
    </attributeEstimate>
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</Evidence>