Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot3 - STU 1 Ballot 3 World

Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot3 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions

: Example of statistical model expression

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@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

<http://hl7.org/fhir/Evidence/587629> a fhir:Evidence ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "587629"] ; # 
  fhir:meta [
     fhir:versionId [ fhir:v "4" ] ;
     fhir:lastUpdated [ fhir:v "2026-08-03T18:52:42.905Z"^^xsd:dateTime ] ;
     fhir:profile ( [
       fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model"^^xsd:anyURI ;
       fhir:l <http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model>
     ] )
  ] ; # 
  fhir:language [ fhir:v "en"] ; # 
  fhir:text [
     fhir:status [ fhir:v "extensions" ] ;
     fhir:div [ fhir:v "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: Evidence 587629</b></p><a name=\"587629\"> </a><a name=\"hc587629\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">version: 4; Last updated: 2026-08-03 18:52:42+0000</p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-statistic-model.html\">StatisticModel</a></p></div><p><b>ArtifactPublicationStatus</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-status-type active}\">Active</span></p><p><b>url</b>: <a href=\"https://fevir.net/resources/Evidence/587629\">https://fevir.net/resources/Evidence/587629</a></p><p><b>identifier</b>: FEvIR Object Identifier/587629</p><p><b>name</b>: Example_of_statistical_model_expression</p><p><b>title</b>: Example of statistical model expression</p><p><b>citeAs</b>: </p><div><p>Example of statistical model expression [Database Entry: FHIR Evidence Resource]. Contributors: Brian S. Alper, MD, MSPH [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 587629. Revised 2026-08-03. Available at: https://fevir.net/resources/Evidence/587629. Computable resource at: https://fevir.net/resources/Evidence/587629#json.</p>\n</div><p><b>status</b>: Active</p><p><b>author</b>: Brian S. Alper, MD, MSPH: </p><p><b>publisher</b>: Computable Publishing LLC</p><p><b>contact</b>: <a href=\"mailto:support@computablepublishing.com\">support@computablepublishing.com</a></p><p><b>copyright</b>: </p><div><p>Copyright the Authors else Computable Publishing LLC. Noncommercial use permitted with CC BY-NC-SA 4.0 (https://creativecommons.org/licenses/by-nc-sa/4.0/). Commercial use permitted as agreed in Terms of Use (https://fevir.net/termsofuse).</p>\n</div><p><b>description</b>: </p><div><p>This is an example of madeup Evidence to demonstrate the StatisticalModelExpression extension.</p>\n</div><blockquote><p><b>variableDefinition</b></p><p><b>description</b>: </p><div><p>Patients with diabetes</p>\n</div><p><b>variableRole</b>: Population</p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>description</b>: </p><div><p>GroupAssignment: Treatment vs. Control</p>\n</div><p><b>variableRole</b>: Exposure</p><p><b>comparatorCategory</b>: Control</p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>description</b>: </p><div><p>The primary outcome</p>\n</div><p><b>variableRole</b>: Outcome</p></blockquote><blockquote><p><b>statistic</b></p><p><b>StatisticModelExpression</b>: <span title=\"text/r\"><code>glm(Outcome ~ Treatment + Baseline_A1C + Age, family = binomial(link = 'logit'))</code></span>(\"Logistic regression formula used to calculate the adjusted odds ratio for the primary endpoint.\")</p><p><b>description</b>: </p><div><p>Adjusted Odds Ratio for primary outcome 1.45 (95% CI .12 to 1.88)</p>\n</div><p><b>statisticType</b>: <span title=\"Codes:{https://fevir.net/sevco STATO:0000182}\">odds ratio</span></p><p><b>quantity</b>: 1.45</p><h3>AttributeEstimates</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://terminology.hl7.org/CodeSystem/attribute-estimate-type C53324}\">Confidence interval</span></td><td>1.12-1.88</td></tr></table></blockquote></div>"^^rdf:XMLLiteral ]
  ] ; # 
  fhir:extension ( [
     fhir:url [
       fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/artifact-publication-status"^^xsd:anyURI ;
       fhir:l <http://hl7.org/fhir/uv/ebm/StructureDefinition/artifact-publication-status>
     ] ;
     fhir:value [
       a fhir:CodeableConcept ;
       fhir:coding ( [
         fhir:system [
           fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-status-type"^^xsd:anyURI ;
           fhir:l <http://terminology.hl7.org/CodeSystem/cited-artifact-status-type>
         ] ;
         fhir:code [ fhir:v "active" ] ;
         fhir:display [ fhir:v "Active" ]
       ] )
     ]
  ] ) ; # 
  fhir:url [
     fhir:v "https://fevir.net/resources/Evidence/587629"^^xsd:anyURI ;
     fhir:l <https://fevir.net/resources/Evidence/587629>
  ] ; # 
  fhir:identifier ( [
     fhir:type [
       fhir:coding ( [
         fhir:system [
           fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ;
           fhir:l <http://terminology.hl7.org/CodeSystem/v2-0203>
         ] ;
         fhir:code [ fhir:v "ACSN" ] ;
         fhir:display [ fhir:v "Accession ID" ]
       ] ) ;
       fhir:text [ fhir:v "FEvIR Object Identifier" ]
     ] ;
     fhir:system [
       fhir:v "https://fevir.net/FOI"^^xsd:anyURI ;
       fhir:l <https://fevir.net/FOI>
     ] ;
     fhir:value [ fhir:v "587629" ] ;
     fhir:assigner [
       fhir:display [ fhir:v "Computable Publishing LLC" ]
     ]
  ] ) ; # 
  fhir:name [ fhir:v "Example_of_statistical_model_expression"] ; # 
  fhir:title [ fhir:v "Example of statistical model expression"] ; # 
  fhir:citeAs [ fhir:v "Example of statistical model expression [Database Entry: FHIR Evidence Resource]. Contributors: Brian S. Alper, MD, MSPH [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 587629. Revised 2026-08-03. Available at: https://fevir.net/resources/Evidence/587629. Computable resource at: https://fevir.net/resources/Evidence/587629#json."] ; # 
  fhir:status [ fhir:v "active"] ; # 
  fhir:author ( [
     fhir:name [ fhir:v "Brian S. Alper, MD, MSPH" ]
  ] ) ; # 
  fhir:publisher [ fhir:v "Computable Publishing LLC"] ; # 
  fhir:contact ( [
     fhir:telecom ( [
       fhir:system [ fhir:v "email" ] ;
       fhir:value [ fhir:v "support@computablepublishing.com" ]
     ] )
  ] ) ; # 
  fhir:copyright [ fhir:v "Copyright the Authors else Computable Publishing LLC. Noncommercial use permitted with CC BY-NC-SA 4.0 (https://creativecommons.org/licenses/by-nc-sa/4.0/). Commercial use permitted as agreed in Terms of Use (https://fevir.net/termsofuse)."] ; # 
  fhir:description [ fhir:v "This is an example of madeup Evidence to demonstrate the StatisticalModelExpression extension."] ; # 
  fhir:variableDefinition ( [
     fhir:description [ fhir:v "Patients with diabetes" ] ;
     fhir:variableRole [ fhir:v "population" ]
  ] [
     fhir:description [ fhir:v "GroupAssignment: Treatment vs. Control" ] ;
     fhir:variableRole [ fhir:v "exposure" ] ;
     fhir:comparatorCategory [ fhir:v "Control" ]
  ] [
     fhir:description [ fhir:v "The primary outcome" ] ;
     fhir:variableRole [ fhir:v "outcome" ]
  ] ) ; # 
  fhir:statistic ( [
     fhir:extension ( [
       fhir:url [
         fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-expression"^^xsd:anyURI ;
         fhir:l <http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-expression>
       ] ;
       fhir:value [
         a fhir:Expression ;
         fhir:description [ fhir:v "Logistic regression formula used to calculate the adjusted odds ratio for the primary endpoint." ] ;
         fhir:language [ fhir:v "text/r" ] ;
         fhir:expression [ fhir:v "glm(Outcome ~ Treatment + Baseline_A1C + Age, family = binomial(link = 'logit'))" ]
       ]
     ] ) ;
     fhir:description [ fhir:v "Adjusted Odds Ratio for primary outcome 1.45 (95% CI .12 to 1.88)" ] ;
     fhir:statisticType [
       fhir:coding ( [
         fhir:system [
           fhir:v "https://fevir.net/sevco"^^xsd:anyURI ;
           fhir:l <https://fevir.net/sevco>
         ] ;
         fhir:code [ fhir:v "STATO:0000182" ] ;
         fhir:display [ fhir:v "odds ratio" ]
       ] )
     ] ;
     fhir:quantity [
       fhir:value [ fhir:v 1.45 ]
     ] ;
     fhir:attributeEstimate ( [
       fhir:type [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://terminology.hl7.org/CodeSystem/attribute-estimate-type"^^xsd:anyURI ;
             fhir:l <http://terminology.hl7.org/CodeSystem/attribute-estimate-type>
           ] ;
           fhir:code [ fhir:v "C53324" ] ;
           fhir:display [ fhir:v "Confidence interval" ]
         ] )
       ] ;
       fhir:range [
         fhir:low [
           fhir:value [ fhir:v 1.12 ]
         ] ;
         fhir:high [
           fhir:value [ fhir:v 1.88 ]
         ]
       ]
     ] )
  ] ) . #