Clinical Genomics Resource Incubator
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Clinical Genomics Resource Incubator, published by HL7 International / Clinical Genomics. This guide is not an authorized publication; it is the continuous build for version 0.1.0-ci-build built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/cg-incubator/ and changes regularly. See the Directory of published versions

: Molecular Definition Type CodeSystem

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<CodeSystem xmlns="http://hl7.org/fhir">
  <id value="moleculardefinition-type"/>
  <meta>
    <lastUpdated value="2026-03-23T00:00:00Z"/>
    <profile
             value="http://hl7.org/fhir/StructureDefinition/shareablecodesystem"/>
  </meta>
  <language value="en"/>
  <text>
    <status value="generated"/>
    <div xmlns="http://www.w3.org/1999/xhtml"><p class="res-header-id"><b>Generated Narrative: CodeSystem moleculardefinition-type</b></p><a name="moleculardefinition-type"> </a><a name="hcmoleculardefinition-type"> </a><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Last updated: 2026-03-23 00:00:00+0000</p><p style="margin-bottom: 0px">Profile: <a href="http://hl7.org/fhir/R5/shareablecodesystem.html">Shareable CodeSystem</a></p></div><p>This case-sensitive code system <code>http://hl7.org/fhir/uv/cg-incubator/CodeSystem/moleculardefinition-type</code> defines the following codes:</p><table class="codes"><tr><td style="white-space:nowrap"><b>Code</b></td><td><b>Display</b></td><td><b>Definition</b></td></tr><tr><td style="white-space:nowrap">genomic-dna<a name="moleculardefinition-type-genomic-dna"> </a></td><td>Genomic DNA</td><td>DNA that encodes, or is derived from, the genomic DNA of an organism.</td></tr><tr><td style="white-space:nowrap">cdna<a name="moleculardefinition-type-cdna"> </a></td><td>cDNA</td><td>A DNA molecule synthesized from a mature mRNA template by reverse transcriptase.</td></tr><tr><td style="white-space:nowrap">single-stranded-cdna<a name="moleculardefinition-type-single-stranded-cdna"> </a></td><td>Single-stranded cDNA</td><td>A cDNA molecule that is single-stranded.</td></tr><tr><td style="white-space:nowrap">double-stranded-cdna<a name="moleculardefinition-type-double-stranded-cdna"> </a></td><td>Double-stranded cDNA</td><td>A cDNA molecule that is double-stranded.</td></tr><tr><td style="white-space:nowrap">mitochondrial-dna<a name="moleculardefinition-type-mitochondrial-dna"> </a></td><td>Mitochondrial DNA</td><td>A DNA sequence of mitochondrial origin.</td></tr><tr><td style="white-space:nowrap">mrna<a name="moleculardefinition-type-mrna"> </a></td><td>mRNA</td><td>Messenger RNA; a mature transcript that is translated into protein.</td></tr><tr><td style="white-space:nowrap">rrna<a name="moleculardefinition-type-rrna"> </a></td><td>rRNA</td><td>Ribosomal RNA; a structural component of the ribosome.</td></tr><tr><td style="white-space:nowrap">trna<a name="moleculardefinition-type-trna"> </a></td><td>tRNA</td><td>Transfer RNA; an adaptor molecule for translation.</td></tr><tr><td style="white-space:nowrap">snrna<a name="moleculardefinition-type-snrna"> </a></td><td>snRNA</td><td>Small nuclear RNA; involved in pre-mRNA splicing.</td></tr><tr><td style="white-space:nowrap">snorna<a name="moleculardefinition-type-snorna"> </a></td><td>snoRNA</td><td>Small nucleolar RNA; involved in rRNA modification.</td></tr><tr><td style="white-space:nowrap">mirna<a name="moleculardefinition-type-mirna"> </a></td><td>miRNA</td><td>MicroRNA; a small regulatory RNA that silences gene expression.</td></tr><tr><td style="white-space:nowrap">sirna<a name="moleculardefinition-type-sirna"> </a></td><td>siRNA</td><td>Small interfering RNA; mediates RNA interference.</td></tr><tr><td style="white-space:nowrap">lncrna<a name="moleculardefinition-type-lncrna"> </a></td><td>lncRNA</td><td>Long non-coding RNA; an ncRNA of 200 nucleotides or more with regulatory roles.</td></tr><tr><td style="white-space:nowrap">antisense-rna<a name="moleculardefinition-type-antisense-rna"> </a></td><td>Antisense RNA</td><td>RNA transcribed from the antisense strand of a gene.</td></tr><tr><td style="white-space:nowrap">ncrna<a name="moleculardefinition-type-ncrna"> </a></td><td>ncRNA</td><td>Non-coding RNA; a mature transcript that is not translated into protein.</td></tr><tr><td style="white-space:nowrap">pirna<a name="moleculardefinition-type-pirna"> </a></td><td>piRNA</td><td>PIWI-interacting RNA; involved in transposon silencing in germline cells.</td></tr></table></div>
  </text>
  <extension
             url="http://hl7.org/fhir/StructureDefinition/structuredefinition-wg">
    <valueCode value="cg"/>
  </extension>
  <extension
             url="http://hl7.org/fhir/StructureDefinition/structuredefinition-standards-status">
    <valueCode value="informative"/>
  </extension>
  <extension
             url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fmm">
    <valueInteger value="0"/>
  </extension>
  <url
       value="http://hl7.org/fhir/uv/cg-incubator/CodeSystem/moleculardefinition-type"/>
  <identifier>
    <system value="urn:ietf:rfc:3986"/>
    <value value="urn:oid:2.16.840.1.113883.4.642.4.3002"/>
  </identifier>
  <version value="0.1.0-ci-build"/>
  <name value="MolecularDefinitionType"/>
  <title value="Molecular Definition Type CodeSystem"/>
  <status value="draft"/>
  <experimental value="true"/>
  <date value="2026-03-23"/>
  <publisher value="HL7 International / Clinical Genomics"/>
  <contact>
    <name value="HL7 International / Clinical Genomics"/>
    <telecom>
      <system value="url"/>
      <value value="http://www.hl7.org/Special/committees/clingenomics"/>
    </telecom>
    <telecom>
      <system value="email"/>
      <value value="clingenomics@lists.hl7.org"/>
    </telecom>
  </contact>
  <description
               value="Domain-semantic subtype classifications for a MolecularDefinition resource instance, providing greater specificity than the moleculeType element. For example, an instance with moleculeType 'rna' may have a type of 'mrna' or 'mirna'. This CodeSystem is an enumerated, curated set covering clinically relevant DNA and RNA subtypes. The binding on this CodeSystem is extensible: implementers may use codes from other systems when no suitable code exists here."/>
  <jurisdiction>
    <coding>
      <system value="http://unstats.un.org/unsd/methods/m49/m49.htm"/>
      <code value="001"/>
      <display value="World"/>
    </coding>
  </jurisdiction>
  <caseSensitive value="true"/>
  <valueSet
            value="http://hl7.org/fhir/uv/cg-incubator/ValueSet/moleculardefinition-type"/>
  <content value="complete"/>
  <concept>
    <code value="genomic-dna"/>
    <display value="Genomic DNA"/>
    <definition
                value="DNA that encodes, or is derived from, the genomic DNA of an organism."/>
  </concept>
  <concept>
    <code value="cdna"/>
    <display value="cDNA"/>
    <definition
                value="A DNA molecule synthesized from a mature mRNA template by reverse transcriptase."/>
  </concept>
  <concept>
    <code value="single-stranded-cdna"/>
    <display value="Single-stranded cDNA"/>
    <definition value="A cDNA molecule that is single-stranded."/>
  </concept>
  <concept>
    <code value="double-stranded-cdna"/>
    <display value="Double-stranded cDNA"/>
    <definition value="A cDNA molecule that is double-stranded."/>
  </concept>
  <concept>
    <code value="mitochondrial-dna"/>
    <display value="Mitochondrial DNA"/>
    <definition value="A DNA sequence of mitochondrial origin."/>
  </concept>
  <concept>
    <code value="mrna"/>
    <display value="mRNA"/>
    <definition
                value="Messenger RNA; a mature transcript that is translated into protein."/>
  </concept>
  <concept>
    <code value="rrna"/>
    <display value="rRNA"/>
    <definition
                value="Ribosomal RNA; a structural component of the ribosome."/>
  </concept>
  <concept>
    <code value="trna"/>
    <display value="tRNA"/>
    <definition value="Transfer RNA; an adaptor molecule for translation."/>
  </concept>
  <concept>
    <code value="snrna"/>
    <display value="snRNA"/>
    <definition value="Small nuclear RNA; involved in pre-mRNA splicing."/>
  </concept>
  <concept>
    <code value="snorna"/>
    <display value="snoRNA"/>
    <definition value="Small nucleolar RNA; involved in rRNA modification."/>
  </concept>
  <concept>
    <code value="mirna"/>
    <display value="miRNA"/>
    <definition
                value="MicroRNA; a small regulatory RNA that silences gene expression."/>
  </concept>
  <concept>
    <code value="sirna"/>
    <display value="siRNA"/>
    <definition value="Small interfering RNA; mediates RNA interference."/>
  </concept>
  <concept>
    <code value="lncrna"/>
    <display value="lncRNA"/>
    <definition
                value="Long non-coding RNA; an ncRNA of 200 nucleotides or more with regulatory roles."/>
  </concept>
  <concept>
    <code value="antisense-rna"/>
    <display value="Antisense RNA"/>
    <definition value="RNA transcribed from the antisense strand of a gene."/>
  </concept>
  <concept>
    <code value="ncrna"/>
    <display value="ncRNA"/>
    <definition
                value="Non-coding RNA; a mature transcript that is not translated into protein."/>
  </concept>
  <concept>
    <code value="pirna"/>
    <display value="piRNA"/>
    <definition
                value="PIWI-interacting RNA; involved in transposon silencing in germline cells."/>
  </concept>
</CodeSystem>