Clinical Genomics Resource Incubator
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Clinical Genomics Resource Incubator, published by HL7 International / Clinical Genomics. This guide is not an authorized publication; it is the continuous build for version 0.1.0-ci-build built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/cg-incubator/ and changes regularly. See the Directory of published versions

: Molecular Definition Type CodeSystem

Page standards status: Informative Maturity Level: 0

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@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

 a fhir:CodeSystem ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "moleculardefinition-type"] ; # 
  fhir:meta [
fhir:lastUpdated [ fhir:v "2026-03-23T00:00:00Z"^^xsd:dateTime ] ;
    ( fhir:profile [
fhir:v "http://hl7.org/fhir/StructureDefinition/shareablecodesystem"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/StructureDefinition/shareablecodesystem>     ] )
  ] ; # 
  fhir:language [ fhir:v "en"] ; # 
  fhir:text [
fhir:status [ fhir:v "generated" ] ;
fhir:div [ fhir:v "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: CodeSystem moleculardefinition-type</b></p><a name=\"moleculardefinition-type\"> </a><a name=\"hcmoleculardefinition-type\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Last updated: 2026-03-23 00:00:00+0000</p><p style=\"margin-bottom: 0px\">Profile: <a href=\"http://hl7.org/fhir/R5/shareablecodesystem.html\">Shareable CodeSystem</a></p></div><p>This case-sensitive code system <code>http://hl7.org/fhir/uv/cg-incubator/CodeSystem/moleculardefinition-type</code> defines the following codes:</p><table class=\"codes\"><tr><td style=\"white-space:nowrap\"><b>Code</b></td><td><b>Display</b></td><td><b>Definition</b></td></tr><tr><td style=\"white-space:nowrap\">genomic-dna<a name=\"moleculardefinition-type-genomic-dna\"> </a></td><td>Genomic DNA</td><td>DNA that encodes, or is derived from, the genomic DNA of an organism.</td></tr><tr><td style=\"white-space:nowrap\">cdna<a name=\"moleculardefinition-type-cdna\"> </a></td><td>cDNA</td><td>A DNA molecule synthesized from a mature mRNA template by reverse transcriptase.</td></tr><tr><td style=\"white-space:nowrap\">single-stranded-cdna<a name=\"moleculardefinition-type-single-stranded-cdna\"> </a></td><td>Single-stranded cDNA</td><td>A cDNA molecule that is single-stranded.</td></tr><tr><td style=\"white-space:nowrap\">double-stranded-cdna<a name=\"moleculardefinition-type-double-stranded-cdna\"> </a></td><td>Double-stranded cDNA</td><td>A cDNA molecule that is double-stranded.</td></tr><tr><td style=\"white-space:nowrap\">mitochondrial-dna<a name=\"moleculardefinition-type-mitochondrial-dna\"> </a></td><td>Mitochondrial DNA</td><td>A DNA sequence of mitochondrial origin.</td></tr><tr><td style=\"white-space:nowrap\">mrna<a name=\"moleculardefinition-type-mrna\"> </a></td><td>mRNA</td><td>Messenger RNA; a mature transcript that is translated into protein.</td></tr><tr><td style=\"white-space:nowrap\">rrna<a name=\"moleculardefinition-type-rrna\"> </a></td><td>rRNA</td><td>Ribosomal RNA; a structural component of the ribosome.</td></tr><tr><td style=\"white-space:nowrap\">trna<a name=\"moleculardefinition-type-trna\"> </a></td><td>tRNA</td><td>Transfer RNA; an adaptor molecule for translation.</td></tr><tr><td style=\"white-space:nowrap\">snrna<a name=\"moleculardefinition-type-snrna\"> </a></td><td>snRNA</td><td>Small nuclear RNA; involved in pre-mRNA splicing.</td></tr><tr><td style=\"white-space:nowrap\">snorna<a name=\"moleculardefinition-type-snorna\"> </a></td><td>snoRNA</td><td>Small nucleolar RNA; involved in rRNA modification.</td></tr><tr><td style=\"white-space:nowrap\">mirna<a name=\"moleculardefinition-type-mirna\"> </a></td><td>miRNA</td><td>MicroRNA; a small regulatory RNA that silences gene expression.</td></tr><tr><td style=\"white-space:nowrap\">sirna<a name=\"moleculardefinition-type-sirna\"> </a></td><td>siRNA</td><td>Small interfering RNA; mediates RNA interference.</td></tr><tr><td style=\"white-space:nowrap\">lncrna<a name=\"moleculardefinition-type-lncrna\"> </a></td><td>lncRNA</td><td>Long non-coding RNA; an ncRNA of 200 nucleotides or more with regulatory roles.</td></tr><tr><td style=\"white-space:nowrap\">antisense-rna<a name=\"moleculardefinition-type-antisense-rna\"> </a></td><td>Antisense RNA</td><td>RNA transcribed from the antisense strand of a gene.</td></tr><tr><td style=\"white-space:nowrap\">ncrna<a name=\"moleculardefinition-type-ncrna\"> </a></td><td>ncRNA</td><td>Non-coding RNA; a mature transcript that is not translated into protein.</td></tr><tr><td style=\"white-space:nowrap\">pirna<a name=\"moleculardefinition-type-pirna\"> </a></td><td>piRNA</td><td>PIWI-interacting RNA; involved in transposon silencing in germline cells.</td></tr></table></div>"^^rdf:XMLLiteral ]
  ] ; # 
  fhir:extension ( [
fhir:url [
fhir:v "http://hl7.org/fhir/StructureDefinition/structuredefinition-wg"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/StructureDefinition/structuredefinition-wg>     ] ;
fhir:value [
a fhir:Code ;
fhir:v "cg"     ]
  ] [
fhir:url [
fhir:v "http://hl7.org/fhir/StructureDefinition/structuredefinition-standards-status"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/StructureDefinition/structuredefinition-standards-status>     ] ;
fhir:value [
a fhir:Code ;
fhir:v "informative"     ]
  ] [
fhir:url [
fhir:v "http://hl7.org/fhir/StructureDefinition/structuredefinition-fmm"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/StructureDefinition/structuredefinition-fmm>     ] ;
fhir:value [
a fhir:Integer ;
fhir:v 0     ]
  ] ) ; # 
  fhir:url [
fhir:v "http://hl7.org/fhir/uv/cg-incubator/CodeSystem/moleculardefinition-type"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/uv/cg-incubator/CodeSystem/moleculardefinition-type>
  ] ; # 
  fhir:identifier ( [
fhir:system [
fhir:v "urn:ietf:rfc:3986"^^xsd:anyURI ;
fhir:l <urn:ietf:rfc:3986>     ] ;
fhir:value [ fhir:v "urn:oid:2.16.840.1.113883.4.642.4.3002" ]
  ] ) ; # 
  fhir:version [ fhir:v "0.1.0-ci-build"] ; # 
  fhir:name [ fhir:v "MolecularDefinitionType"] ; # 
  fhir:title [ fhir:v "Molecular Definition Type CodeSystem"] ; # 
  fhir:status [ fhir:v "draft"] ; # 
  fhir:experimental [ fhir:v true] ; # 
  fhir:date [ fhir:v "2026-03-23"^^xsd:date] ; # 
  fhir:publisher [ fhir:v "HL7 International / Clinical Genomics"] ; # 
  fhir:contact ( [
fhir:name [ fhir:v "HL7 International / Clinical Genomics" ] ;
    ( fhir:telecom [
fhir:system [ fhir:v "url" ] ;
fhir:value [ fhir:v "http://www.hl7.org/Special/committees/clingenomics" ]     ] [
fhir:system [ fhir:v "email" ] ;
fhir:value [ fhir:v "clingenomics@lists.hl7.org" ]     ] )
  ] ) ; # 
  fhir:description [ fhir:v "Domain-semantic subtype classifications for a MolecularDefinition resource instance, providing greater specificity than the moleculeType element. For example, an instance with moleculeType 'rna' may have a type of 'mrna' or 'mirna'. This CodeSystem is an enumerated, curated set covering clinically relevant DNA and RNA subtypes. The binding on this CodeSystem is extensible: implementers may use codes from other systems when no suitable code exists here."] ; # 
  fhir:jurisdiction ( [
    ( fhir:coding [
fhir:system [
fhir:v "http://unstats.un.org/unsd/methods/m49/m49.htm"^^xsd:anyURI ;
fhir:l <http://unstats.un.org/unsd/methods/m49/m49.htm>       ] ;
fhir:code [ fhir:v "001" ] ;
fhir:display [ fhir:v "World" ]     ] )
  ] ) ; # 
  fhir:caseSensitive [ fhir:v true] ; # 
  fhir:valueSet [
fhir:v "http://hl7.org/fhir/uv/cg-incubator/ValueSet/moleculardefinition-type"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/uv/cg-incubator/ValueSet/moleculardefinition-type>
  ] ; # 
  fhir:content [ fhir:v "complete"] ; # 
  fhir:concept ( [
fhir:code [ fhir:v "genomic-dna" ] ;
fhir:display [ fhir:v "Genomic DNA" ] ;
fhir:definition [ fhir:v "DNA that encodes, or is derived from, the genomic DNA of an organism." ]
  ] [
fhir:code [ fhir:v "cdna" ] ;
fhir:display [ fhir:v "cDNA" ] ;
fhir:definition [ fhir:v "A DNA molecule synthesized from a mature mRNA template by reverse transcriptase." ]
  ] [
fhir:code [ fhir:v "single-stranded-cdna" ] ;
fhir:display [ fhir:v "Single-stranded cDNA" ] ;
fhir:definition [ fhir:v "A cDNA molecule that is single-stranded." ]
  ] [
fhir:code [ fhir:v "double-stranded-cdna" ] ;
fhir:display [ fhir:v "Double-stranded cDNA" ] ;
fhir:definition [ fhir:v "A cDNA molecule that is double-stranded." ]
  ] [
fhir:code [ fhir:v "mitochondrial-dna" ] ;
fhir:display [ fhir:v "Mitochondrial DNA" ] ;
fhir:definition [ fhir:v "A DNA sequence of mitochondrial origin." ]
  ] [
fhir:code [ fhir:v "mrna" ] ;
fhir:display [ fhir:v "mRNA" ] ;
fhir:definition [ fhir:v "Messenger RNA; a mature transcript that is translated into protein." ]
  ] [
fhir:code [ fhir:v "rrna" ] ;
fhir:display [ fhir:v "rRNA" ] ;
fhir:definition [ fhir:v "Ribosomal RNA; a structural component of the ribosome." ]
  ] [
fhir:code [ fhir:v "trna" ] ;
fhir:display [ fhir:v "tRNA" ] ;
fhir:definition [ fhir:v "Transfer RNA; an adaptor molecule for translation." ]
  ] [
fhir:code [ fhir:v "snrna" ] ;
fhir:display [ fhir:v "snRNA" ] ;
fhir:definition [ fhir:v "Small nuclear RNA; involved in pre-mRNA splicing." ]
  ] [
fhir:code [ fhir:v "snorna" ] ;
fhir:display [ fhir:v "snoRNA" ] ;
fhir:definition [ fhir:v "Small nucleolar RNA; involved in rRNA modification." ]
  ] [
fhir:code [ fhir:v "mirna" ] ;
fhir:display [ fhir:v "miRNA" ] ;
fhir:definition [ fhir:v "MicroRNA; a small regulatory RNA that silences gene expression." ]
  ] [
fhir:code [ fhir:v "sirna" ] ;
fhir:display [ fhir:v "siRNA" ] ;
fhir:definition [ fhir:v "Small interfering RNA; mediates RNA interference." ]
  ] [
fhir:code [ fhir:v "lncrna" ] ;
fhir:display [ fhir:v "lncRNA" ] ;
fhir:definition [ fhir:v "Long non-coding RNA; an ncRNA of 200 nucleotides or more with regulatory roles." ]
  ] [
fhir:code [ fhir:v "antisense-rna" ] ;
fhir:display [ fhir:v "Antisense RNA" ] ;
fhir:definition [ fhir:v "RNA transcribed from the antisense strand of a gene." ]
  ] [
fhir:code [ fhir:v "ncrna" ] ;
fhir:display [ fhir:v "ncRNA" ] ;
fhir:definition [ fhir:v "Non-coding RNA; a mature transcript that is not translated into protein." ]
  ] [
fhir:code [ fhir:v "pirna" ] ;
fhir:display [ fhir:v "piRNA" ] ;
fhir:definition [ fhir:v "PIWI-interacting RNA; involved in transposon silencing in germline cells." ]
  ] ) . #