HL7 Terminology (THO)
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HL7 Terminology (THO), published by HL7 International - Vocabulary Work Group. This guide is not an authorized publication; it is the continuous build for version 7.4.11 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/UTG/ and changes regularly. See the Directory of published versions

: Detected Issue Clinical Impact

Page standards status: Trial-use Maturity Level: 3

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{
  "resourceType" : "CodeSystem",
  "id" : "detectedissue-clinical-impact",
  "language" : "en",
  "text" : {
    "status" : "generated",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: CodeSystem detectedissue-clinical-impact</b></p><a name=\"detectedissue-clinical-impact\"> </a><a name=\"hcdetectedissue-clinical-impact\"> </a><p>This case-sensitive code system <code>http://terminology.hl7.org/CodeSystem/detectedissue-clinical-impact</code> defines the following codes:</p><table class=\"codes\"><tr><td style=\"white-space:nowrap\"><b>Code</b></td><td><b>Display</b></td><td><b>Definition</b></td></tr><tr><td style=\"white-space:nowrap\">increased-effect<a name=\"detectedissue-clinical-impact-increased-effect\"> </a></td><td>Increased effect</td><td>The clinical or pharmacologic effect is expected to be increased for one or more implicated therapies.</td></tr><tr><td style=\"white-space:nowrap\">decreased-effect<a name=\"detectedissue-clinical-impact-decreased-effect\"> </a></td><td>Decreased effect</td><td>The clinical or pharmacologic effect is expected to be decreased for one or more implicated therapies.</td></tr><tr><td style=\"white-space:nowrap\">mixed-effect<a name=\"detectedissue-clinical-impact-mixed-effect\"> </a></td><td>Mixed effect</td><td>Mixed or differing changes in clinical or pharmacologic effects are expected.</td></tr><tr><td style=\"white-space:nowrap\">adverse-reaction<a name=\"detectedissue-clinical-impact-adverse-reaction\"> </a></td><td>Adverse reaction</td><td>An adverse reaction is expected or its risk is increased.</td></tr><tr><td style=\"white-space:nowrap\">additive-adverse-effects<a name=\"detectedissue-clinical-impact-additive-adverse-effects\"> </a></td><td>Additive adverse effects</td><td>Adverse or undesirable effects are expected to be additive for one or more implicated therapies.</td></tr><tr><td style=\"white-space:nowrap\">avoid-concurrent-use<a name=\"detectedissue-clinical-impact-avoid-concurrent-use\"> </a></td><td>Avoid concurrent use when possible</td><td>Concurrent use should generally be avoided because of the identified clinical risk.</td></tr><tr><td style=\"white-space:nowrap\">contraindicated-in-some-patients<a name=\"detectedissue-clinical-impact-contraindicated-in-some-patients\"> </a></td><td>Contraindicated in some patients</td><td>Concurrent use is contraindicated for a subset of patients based on patient-specific clinical characteristics or circumstances.</td></tr></table></div>"
  },
  "extension" : [
    {
      "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-wg",
      "valueCode" : "cds"
    },
    {
      "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-standards-status",
      "valueCode" : "trial-use"
    },
    {
      "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-fmm",
      "valueInteger" : 3
    }
  ],
  "url" : "http://terminology.hl7.org/CodeSystem/detectedissue-clinical-impact",
  "version" : "1.0.0",
  "name" : "DetectedIssueClinicalImpact",
  "title" : "Detected Issue Clinical Impact",
  "status" : "active",
  "experimental" : false,
  "date" : "2026-09-14",
  "publisher" : "Health Level Seven International",
  "contact" : [
    {
      "telecom" : [
        {
          "system" : "url",
          "value" : "http://hl7.org"
        },
        {
          "system" : "email",
          "value" : "hq@HL7.org"
        }
      ]
    }
  ],
  "description" : "Codes that describe the potential clinical impact of a detected issue.",
  "copyright" : "This material derives from the HL7 Terminology (THO). THO is copyright ©1989+ Health Level Seven International and is made available under the CC0 designation. For more licensing information see: https://terminology.hl7.org/license",
  "caseSensitive" : true,
  "valueSet" : "http://terminology.hl7.org/ValueSet/detectedissue-clinical-impact",
  "content" : "complete",
  "concept" : [
    {
      "code" : "increased-effect",
      "display" : "Increased effect",
      "definition" : "The clinical or pharmacologic effect is expected to be increased for one or more implicated therapies."
    },
    {
      "code" : "decreased-effect",
      "display" : "Decreased effect",
      "definition" : "The clinical or pharmacologic effect is expected to be decreased for one or more implicated therapies."
    },
    {
      "code" : "mixed-effect",
      "display" : "Mixed effect",
      "definition" : "Mixed or differing changes in clinical or pharmacologic effects are expected."
    },
    {
      "code" : "adverse-reaction",
      "display" : "Adverse reaction",
      "definition" : "An adverse reaction is expected or its risk is increased."
    },
    {
      "code" : "additive-adverse-effects",
      "display" : "Additive adverse effects",
      "definition" : "Adverse or undesirable effects are expected to be additive for one or more implicated therapies."
    },
    {
      "code" : "avoid-concurrent-use",
      "display" : "Avoid concurrent use when possible",
      "definition" : "Concurrent use should generally be avoided because of the identified clinical risk."
    },
    {
      "code" : "contraindicated-in-some-patients",
      "display" : "Contraindicated in some patients",
      "definition" : "Concurrent use is contraindicated for a subset of patients based on patient-specific clinical characteristics or circumstances."
    }
  ]
}