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Evidence-example-stroke-alteplase-fatalICH.xml

Clinical Decision Support Work GroupMaturity Level: N/AStandards Status: InformativeCompartments: Not linked to any defined compartments

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Risk of fatal ICH with alteplase for stroke (id = "example-stroke-alteplase-fatalICH")

<?xml version="1.0" encoding="UTF-8"?>

<Evidence xmlns="http://hl7.org/fhir">
  <id value="example-stroke-alteplase-fatalICH"/> 
  <text> 
    <status value="generated"/> 
    <div xmlns="http://www.w3.org/1999/xhtml">
      <p> 
        &quot;Risk of fatal ICH with alteplase for stroke&quot; is a univariate risk estimate.
      </p> 
  </div> 
  </text> 
  <url value="Evidence/example-stroke-alteplase-fatalICH"/> 
  <title value="Risk of fatal ICH with alteplase for stroke"/> 
  <status value="draft"/> 
  <relatedArtifact> 
  <type value="citation"/> 
  <label value="Emberson 2014"/> 
  <display value="Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis
     with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data
     from randomised trials."/> 
  <citation value="Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E, et al;Stroke Thrombolysis
     Trialists' Collaborative Group. Effect of treatment delay, age, and stroke severity on
     the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis
     of individual patient data from randomised trials. Lancet 2014 Nov 29;384(9958):1929-35
     PMID 25106063"/> 
  <url value="https://doi.org/10.1016/S0140-6736(14)60584-5"/> 
  </relatedArtifact> 
  <description value="2.7% incidence of fatal intracranial hemorrhage within 7 days with alteplase in patients
   with acute ischemic stroke"/> 
  <variableDefinition> 
    <variableRole> 
      <coding> 
        <system value="http://terminology.hl7.org/CodeSystem/variable-role"/> 
        <code value="population"/> 
        <display value="population"/> 
      </coding> 
    </variableRole> 
    <observed> 
      <reference value="Group/AcuteIschemicStroke"/> 
      <type value="Group"/> 
      <display value="adults with acute ischemic stroke"/> 
    </observed> 
    <intended> 
      <reference value="Group/AcuteIschemicStroke"/> 
      <type value="Group"/> 
      <display value="adults with acute ischemic stroke"/> 
    </intended> 
  </variableDefinition> 
  <variableDefinition> 
    <variableRole> 
      <coding> 
        <system value="http://terminology.hl7.org/CodeSystem/variable-role"/> 
        <code value="population"/> 
        <display value="population"/> 
      </coding> 
    </variableRole> 
    <observed> 
      <reference value="Group/Emberson-2014-IPD-MA-Alteplase-Cohort"/> 
      <type value="Group"/> 
      <display value="Emberson 2014 IPD-MA Alteplase Cohort"/> 
    </observed> 
    <intended> 
      <reference value="Group/AcuteIschemicStrokeTreatedWithAlteplase"/> 
      <type value="Group"/> 
      <display value="adults with acute ischemic stroke treated with alteplase"/> 
    </intended> 
  </variableDefinition> 
  <variableDefinition> 
    <variableRole> 
      <coding> 
        <system value="http://terminology.hl7.org/CodeSystem/variable-role"/> 
        <code value="measuredVariable"/> 
        <display value="measured variable"/> 
      </coding> 
    </variableRole> 
    <observed> 
      <reference value="EvidenceVariable/example-fatal-ICH-in-7-days"/> 
      <type value="EvidenceVariable"/> 
      <display value="fatal ICH"/> 
    </observed> 
    <intended> 
      <reference value="EvidenceVariable/example-fatal-ICH-in-7-days"/> 
      <type value="EvidenceVariable"/> 
      <display value="fatal ICH"/> 
    </intended> 
  </variableDefinition> 
  <synthesisType> 
    <coding> 
      <system value="http://terminology.hl7.org/CodeSystem/synthesis-type"/> 
      <code value="IPD-MA"/> 
      <display value="individual patient data meta-analysis"/> 
    </coding> 
  </synthesisType> 
  <studyType> 
    <coding> 
      <system value="http://terminology.hl7.org/CodeSystem/study-type"/> 
      <code value="RCT"/> 
      <display value="randomized trial"/> 
    </coding> 
  </studyType> 
  <statistic> 
    <statisticType> 
      <coding> 
        <system value="http://terminology.hl7.org/CodeSystem/statistic-type"/> 
        <code value="C44256"/> 
        <display value="Proportion"/> 
      </coding> 
    </statisticType> 
    <quantity> 
      <value value="0.026835741669"/> 
    </quantity> 
    <numberOfEvents value="91"/> 
    <sampleSize> 
      <numberOfStudies value="9"/> 
      <numberOfParticipants value="3391"/> 
    </sampleSize> 
  </statistic> 
</Evidence> 

Usage note: every effort has been made to ensure that the examples are correct and useful, but they are not a normative part of the specification.