Risk of fatal ICH with alteplase for stroke (id = "example-stroke-alteplase-fatalICH")

<?xml version="1.0" encoding="UTF-8"?>

<Evidence xmlns="http://hl7.org/fhir">
  <id value="example-stroke-alteplase-fatalICH"/> 
  <text> 
    <status value="generated"/> <div xmlns="http://www.w3.org/1999/xhtml">
      
      <p> 
        &quot;Risk of fatal ICH with alteplase for stroke&quot; is a univariate
         risk estimate.
      </p> 
  
    </div> 
  </text> 
  <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-wg">
    <valueCode value="cds"/> 
  </extension> 
  <url value="http://hl7.org/fhir/Evidence/example-stroke-alteplase-fatalICH"/> 
  <identifier> 
    <system value="urn:ietf:rfc:3986"/> 
    <value value="urn:oid:2.16.840.1.113883.4.642.10.1"/> 
  </identifier> 
  <name value="RiskOfFatalICHWithAlteplaseForStroke"/> 
  <title value="Risk of fatal ICH with alteplase for stroke"/> 
  <status value="draft"/> 
  <publisher value="HL7 International / Clinical Decision Support"/> 
  <contact> 
    <telecom> 
      <system value="url"/> 
      <value value="http://www.hl7.org/Special/committees/dss"/> 
    </telecom> 
  </contact> 
  <relatedArtifact> 
    <type value="citation"/> 
    <label value="Emberson 2014"/> 
    <display value="Effect of treatment delay, age, and stroke severity on the effects of intravenous
     thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual
     patient data from randomised trials."/> 
    <citation value="Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E, et al;Stroke Thrombolysis
     Trialists' Collaborative Group. Effect of treatment delay, age, and stroke severity
     on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke:
     a meta-analysis of individual patient data from randomised trials. Lancet 2014
     Nov 29;384(9958):1929-35 PMID 25106063"/> 
    <document> 
      <url value="https://doi.org/10.1016/S0140-6736(14)60584-5"/> 
    </document> 
  </relatedArtifact> 
  <description value="2.7% incidence of fatal intracranial hemorrhage within 7 days with alteplase in
   patients with acute ischemic stroke"/> 
  <variableDefinition> 
    <variableRole value="population"/> 
    <observed> 
      <reference value="Group/Emberson-2014-IPD-MA-Alteplase-Cohort"/> 
      <type value="Group"/> 
      <display value="Emberson 2014 IPD-MA Alteplase Cohort"/> 
    </observed> 
    <intended> 
      <reference value="Group/AcuteIschemicStrokeTreatedWithAlteplase"/> 
      <type value="Group"/> 
      <display value="adults with acute ischemic stroke treated with alteplase"/> 
    </intended> 
  </variableDefinition> 
  <variableDefinition> 
    <variableRole value="outcome"/> 
    <observed> 
      <reference value="EvidenceVariable/example-fatal-ICH-in-7-days"/> 
      <type value="EvidenceVariable"/> 
      <display value="fatal ICH"/> 
    </observed> 
    <intended> 
      <reference value="EvidenceVariable/example-fatal-ICH-in-7-days"/> 
      <type value="EvidenceVariable"/> 
      <display value="fatal ICH"/> 
    </intended> 
  </variableDefinition> 
  <synthesisType> 
    <coding> 
      <system value="http://terminology.hl7.org/CodeSystem/synthesis-type"/> 
      <code value="IPD-MA"/> 
      <display value="individual patient data meta-analysis"/> 
    </coding> 
  </synthesisType> 
  <studyDesign> 
    <coding> 
      <system value="http://hl7.org/fhir/study-design"/> 
      <code value="SEVCO:01003"/> 
      <display value="randomized assignment"/> 
    </coding> 
  </studyDesign> 
  <statistic> 
    <statisticType> 
      <coding> 
        <system value="http://terminology.hl7.org/CodeSystem/statistic-type"/> 
        <code value="C44256"/> 
        <display value="Proportion"/> 
      </coding> 
    </statisticType> 
    <quantity> 
      <value value="0.026835741669"/> 
    </quantity> 
    <numberOfEvents value="91"/> 
    <sampleSize> 
      <numberOfStudies value="9"/> 
      <numberOfParticipants value="3391"/> 
    </sampleSize> 
  </statistic> 
</Evidence>