{"caseSensitive":true,"concept":[{"code":"human","definition":"Glycosylation pattern from human cell lines (e.g. HEK293, PER.C6). No non-human glycan epitopes.","display":"Human"},{"code":"mammalian","definition":"Glycosylation pattern from non-human mammalian cell lines such as CHO, BHK or NS0. The most common pattern for therapeutic monoclonal antibodies.","display":"Mammalian (non-human)"},{"code":"old-world-monkey","definition":"Glycosylation pattern from old world monkey cell lines such as Vero or COS. Often used for vaccine production.","display":"Old World Monkey"},{"code":"mouse","definition":"Glycosylation pattern from murine cell lines such as NS0 or SP2/0 hybridoma. Carries the alpha-1,3-galactose epitope which can be immunogenic in humans.","display":"Murine"},{"code":"mammalian-afucosylated","definition":"Glycosylation pattern from engineered mammalian cell lines lacking fucosyltransferase (e.g. Potelligent), producing antibodies with enhanced ADCC activity.","display":"Mammalian, afucosylated"},{"code":"avian","definition":"Glycosylation pattern from egg-derived or avian cell line production. Common for influenza vaccines.","display":"Avian"},{"code":"insect","definition":"Glycosylation pattern from insect cell expression systems such as baculovirus/Sf9. Used for some recombinant proteins and vaccines.","display":"Insect cell"},{"code":"yeast","definition":"Native yeast glycosylation pattern (e.g. Saccharomyces cerevisiae). Examples include insulin and hepatitis B surface antigen.","display":"Yeast"},{"code":"yeast-humanised","definition":"Glycosylation pattern from glyco-engineered yeast (e.g. Pichia pastoris GlycoFi systems) that produces human-like glycan structures.","display":"Yeast, humanised"},{"code":"plant","definition":"Glycosylation pattern from plant or plant cell culture production (e.g. taliglucerase alfa from carrot cells).","display":"Plant"},{"code":"bacterial","definition":"Bacterial expression (typically E. coli). Generally unglycosylated; included for completeness when the substance has been characterised as such.","display":"Bacterial"}],"contact":[{"telecom":[{"system":"url","value":"http://hl7.org/fhir"},{"system":"email","value":"fhir@lists.hl7.org"}]}],"content":"complete","date":"2026-06-30","description":"A categorical pattern of glycosylation for a substance, typically derived from the production cell line or source organism. Applicable to proteins and structurally diverse substances (notably vaccines) per ISO 11238.","experimental":true,"extension":[{"url":"http://hl7.org/fhir/StructureDefinition/structuredefinition-wg","valueCode":"brr"},{"url":"http://hl7.org/fhir/StructureDefinition/structuredefinition-standards-status","valueCode":"informative"},{"url":"http://hl7.org/fhir/StructureDefinition/structuredefinition-fmm","valueInteger":1}],"id":"substance-glycosylation-type","jurisdiction":[{"coding":[{"code":"001","display":"World","system":"http://unstats.un.org/unsd/methods/m49/m49.htm"}]}],"meta":{"lastUpdated":"2026-07-04T18:53:58.933+00:00"},"name":"SubstanceGlycosylationTypeExample","publisher":"HL7 (FHIR Project)","resourceType":"CodeSystem","status":"active","text":{"div":"

Generated Narrative: CodeSystem substance-glycosylation-type

This case-sensitive code system http://hl7.org/fhir/substance-glycosylation-type defines the following codes:

CodeDisplayDefinition
human HumanGlycosylation pattern from human cell lines (e.g. HEK293, PER.C6). No non-human glycan epitopes.
mammalian Mammalian (non-human)Glycosylation pattern from non-human mammalian cell lines such as CHO, BHK or NS0. The most common pattern for therapeutic monoclonal antibodies.
old-world-monkey Old World MonkeyGlycosylation pattern from old world monkey cell lines such as Vero or COS. Often used for vaccine production.
mouse MurineGlycosylation pattern from murine cell lines such as NS0 or SP2/0 hybridoma. Carries the alpha-1,3-galactose epitope which can be immunogenic in humans.
mammalian-afucosylated Mammalian, afucosylatedGlycosylation pattern from engineered mammalian cell lines lacking fucosyltransferase (e.g. Potelligent), producing antibodies with enhanced ADCC activity.
avian AvianGlycosylation pattern from egg-derived or avian cell line production. Common for influenza vaccines.
insect Insect cellGlycosylation pattern from insect cell expression systems such as baculovirus/Sf9. Used for some recombinant proteins and vaccines.
yeast YeastNative yeast glycosylation pattern (e.g. Saccharomyces cerevisiae). Examples include insulin and hepatitis B surface antigen.
yeast-humanised Yeast, humanisedGlycosylation pattern from glyco-engineered yeast (e.g. Pichia pastoris GlycoFi systems) that produces human-like glycan structures.
plant PlantGlycosylation pattern from plant or plant cell culture production (e.g. taliglucerase alfa from carrot cells).
bacterial BacterialBacterial expression (typically E. coli). Generally unglycosylated; included for completeness when the substance has been characterised as such.
","status":"generated"},"title":"Substance Glycosylation Type","url":"http://hl7.org/fhir/substance-glycosylation-type","valueSet":"http://hl7.org/fhir/ValueSet/substance-glycosylation-type","version":"6.0.0-ballot4"}