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See the Directory of published versions
Example SubstanceDefinition/trastuzumab (Turtle)
Raw Turtle (+ also see Turtle/RDF Format Specification)
Protein substance: Trastuzumab — humanised IgG1 monoclonal antibody targeting HER2
@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
# - resource -------------------------------------------------------------------
# Example: Trastuzumab (humanised monoclonal antibody against HER2).
# Demonstrates the new SubstanceDefinition protein backbones added for
# FHIR-57660: .protein.subunit (heavy + light chains), disulfide linkages,
# N/C-terminal modifications, .protein.gene with humanised mouse origin,
# and .relationship typed as TherapeuticTarget (HER2).
<http://hl7.org/fhir/SubstanceDefinition/trastuzumab> a fhir:SubstanceDefinition ;
fhir:nodeRole fhir:treeRoot ;
fhir:id [ fhir:v "trastuzumab"] ; #
fhir:identifier ( [
fhir:system [
fhir:v "http://example.europa.eu/fhir/SMSId"^^xsd:anyURI ;
fhir:l <http://example.europa.eu/fhir/SMSId>
] ;
fhir:value [ fhir:v "TRAS9123H" ]
] ) ; #
fhir:status [
fhir:coding ( [
fhir:system [
fhir:v "http://hl7.org/fhir/publication-status"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/publication-status>
] ;
fhir:code [ fhir:v "active" ] ;
fhir:display [ fhir:v "Active" ]
] )
] ; #
fhir:classification ( [
fhir:coding ( [
fhir:system [
fhir:v "http://example.europa.eu/fhir/SubstanceType"^^xsd:anyURI ;
fhir:l <http://example.europa.eu/fhir/SubstanceType>
] ;
fhir:code [ fhir:v "protein" ] ;
fhir:display [ fhir:v "Protein" ]
] )
] ) ; #
fhir:domain [
fhir:coding ( [
fhir:system [
fhir:v "http://example.europa.eu/fhir/Domain"^^xsd:anyURI ;
fhir:l <http://example.europa.eu/fhir/Domain>
] ;
fhir:code [ fhir:v "human" ] ;
fhir:display [ fhir:v "Human use" ]
] )
] ; #
fhir:description [ fhir:v "Trastuzumab — humanised IgG1 monoclonal antibody targeting the human epidermal growth factor receptor 2 (HER2/ErbB2). Variable regions derived from murine antibody 4D5, grafted onto human IgG1 framework. Produced in Chinese hamster ovary (CHO) cells."] ; #
fhir:code ( [
fhir:code [
fhir:coding ( [
fhir:system [
fhir:v "http://example.europa.eu/fhir/Substance"^^xsd:anyURI ;
fhir:l <http://example.europa.eu/fhir/Substance>
] ;
fhir:code [ fhir:v "TRAS9123H" ]
] )
]
] ) ; #
fhir:name ( [
fhir:name [ fhir:v "Trastuzumab" ] ;
fhir:preferred [ fhir:v true ] ;
fhir:language ( [
fhir:coding ( [
fhir:system [
fhir:v "urn:ietf:bcp:47"^^xsd:anyURI ;
fhir:l <urn:ietf:bcp:47>
] ;
fhir:code [ fhir:v "en" ] ;
fhir:display [ fhir:v "English" ]
] )
] ) ;
fhir:official ( [
fhir:authority [
fhir:coding ( [
fhir:system [
fhir:v "http://hl7.org/fhir/substance-name-authority"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/substance-name-authority>
] ;
fhir:code [ fhir:v "INN" ] ;
fhir:display [ fhir:v "INN" ]
] )
] ;
fhir:status [
fhir:coding ( [
fhir:system [
fhir:v "http://hl7.org/fhir/publication-status"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/publication-status>
] ;
fhir:code [ fhir:v "active" ] ;
fhir:display [ fhir:v "Active" ]
] )
]
] )
] [
fhir:name [ fhir:v "Herceptin" ] ;
fhir:preferred [ fhir:v false ]
] ) ; #
fhir:protein [
fhir:sequenceType [
fhir:coding ( [
fhir:system [
fhir:v "http://hl7.org/fhir/substance-sequence-type"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/substance-sequence-type>
] ;
fhir:code [ fhir:v "complete" ] ;
fhir:display [ fhir:v "Complete" ]
] )
] ;
fhir:numberOfSubunits [ fhir:v 2 ] ;
fhir:disulfideLinkage ( [ fhir:v "HC22-HC96; HC144-HC200; HC222-LC214; HC228-HC228'; HC231-HC231'; HC265-HC325; HC371-HC429" ] ) ;
fhir:subunit ( [
fhir:subunit [ fhir:v 1 ] ;
fhir:sequence [ fhir:v "EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSS..." ] ;
fhir:length [ fhir:v 450 ] ;
fhir:nTerminalModification [
fhir:concept [
fhir:coding ( [
fhir:system [
fhir:v "http://example.europa.eu/fhir/Modification"^^xsd:anyURI ;
fhir:l <http://example.europa.eu/fhir/Modification>
] ;
fhir:code [ fhir:v "pyroglutamate" ] ;
fhir:display [ fhir:v "Pyroglutamic acid (pE)" ]
] )
]
] ;
fhir:cTerminalModification [
fhir:concept [
fhir:coding ( [
fhir:system [
fhir:v "http://example.europa.eu/fhir/Modification"^^xsd:anyURI ;
fhir:l <http://example.europa.eu/fhir/Modification>
] ;
fhir:code [ fhir:v "lysine-clipped" ] ;
fhir:display [ fhir:v "C-terminal lysine clipping" ]
] )
]
]
] [
fhir:subunit [ fhir:v 2 ] ;
fhir:sequence [ fhir:v "DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIK..." ] ;
fhir:length [ fhir:v 214 ]
] ) ;
fhir:gene ( [
fhir:sequenceOrigin [
fhir:coding ( [
fhir:system [
fhir:v "http://hl7.org/fhir/gene-sequence-origin"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/gene-sequence-origin>
] ;
fhir:code [ fhir:v "humanised-mouse" ] ;
fhir:display [ fhir:v "Humanised mouse" ]
] )
] ;
fhir:gene [
fhir:concept [
fhir:coding ( [
fhir:system [
fhir:v "http://www.genenames.org"^^xsd:anyURI ;
fhir:l <http://www.genenames.org>
] ;
fhir:code [ fhir:v "IGHG1" ] ;
fhir:display [ fhir:v "Immunoglobulin heavy constant gamma 1" ]
] )
]
]
] )
] ; #
fhir:relationship ( [
fhir:substanceDefinition [
a fhir:Reference ;
fhir:l <http://hl7.org/fhir/SubstanceDefinition/her2> ;
fhir:reference [ fhir:v "SubstanceDefinition/her2" ] ;
fhir:display [ fhir:v "Receptor tyrosine-protein kinase erbB-2 (HER2)" ]
] ;
fhir:type [
fhir:coding ( [
fhir:system [
fhir:v "http://hl7.org/fhir/substance-relationship-type"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/substance-relationship-type>
] ;
fhir:code [ fhir:v "TherapeuticTarget" ] ;
fhir:display [ fhir:v "Therapeutic target" ]
] )
] ;
fhir:interaction [
fhir:coding ( [
fhir:system [
fhir:v "http://hl7.org/fhir/substance-interaction-type"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/substance-interaction-type>
] ;
fhir:code [ fhir:v "binding" ] ;
fhir:display [ fhir:v "Binding" ]
] )
] ;
fhir:measurementType [
fhir:coding ( [
fhir:system [
fhir:v "http://hl7.org/fhir/substance-measurement-type"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/substance-measurement-type>
] ;
fhir:code [ fhir:v "kd" ] ;
fhir:display [ fhir:v "Kd" ]
] )
] ;
fhir:amount [
a fhir:Quantity ;
fhir:value [ fhir:v 0.1 ] ;
fhir:unit [ fhir:v "nM" ] ;
fhir:system [
fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ;
fhir:l <http://unitsofmeasure.org>
] ;
fhir:code [ fhir:v "nmol/L" ]
]
] ) . #
<http://hl7.org/fhir/SubstanceDefinition/her2> a fhir:SubstanceDefinition .
# -------------------------------------------------------------------------------------
Usage note: every effort has been made to ensure that the
examples are correct and useful, but they are not a normative part
of the specification.
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