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Example SubstanceDefinition/trastuzumab (Narrative)

Responsible Owner: Biomedical Research and Regulation Work GroupStandards Status: InformativeCompartments: No defined compartments

This is the narrative for the resource. See also the XML, JSON or Turtle format. This example conforms to the profile SubstanceDefinition.

Generated Narrative: SubstanceDefinition trastuzumab

identifier: http://example.europa.eu/fhir/SMSId/TRAS9123H

status: Active

classification: Protein

domain: Human use

description:

Trastuzumab — humanised IgG1 monoclonal antibody targeting the human epidermal growth factor receptor 2 (HER2/ErbB2). Variable regions derived from murine antibody 4D5, grafted onto human IgG1 framework. Produced in Chinese hamster ovary (CHO) cells.

Codes

-Code
* TRAS9123H

name

name: Trastuzumab

preferred: true

language: English

Officials

-AuthorityStatus
* INN Active

name

name: Herceptin

preferred: false

protein

sequenceType: Complete

numberOfSubunits: 2

disulfideLinkage: HC22-HC96; HC144-HC200; HC222-LC214; HC228-HC228'; HC231-HC231'; HC265-HC325; HC371-HC429

subunit

subunit: 1

sequence: EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSS...

length: 450

NTerminalModifications

-Concept
* Pyroglutamic acid (pE)

CTerminalModifications

-Concept
* C-terminal lysine clipping

subunit

subunit: 2

sequence: DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIK...

length: 214

gene

sequenceOrigin: Humanised mouse

Genes

-Concept
* Immunoglobulin heavy constant gamma 1

Relationships

-SubstanceDefinition[x]TypeAmount[x]MeasurementTypeInteraction
* Receptor tyrosine-protein kinase erbB-2 (HER2) Therapeutic target 0.1 nM (Details: UCUM codenmol/L = 'nmol/L') Kd Binding

 

 

Usage note: every effort has been made to ensure that the examples are correct and useful, but they are not a normative part of the specification.