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Example SubstanceDefinition/mipomersen (Turtle)
Raw Turtle (+ also see Turtle/RDF Format Specification)
Nucleic acid substance: Mipomersen sodium — antisense oligonucleotide targeting APOB-100
@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
# - resource -------------------------------------------------------------------
# Example transcribed/adapted from ISO 11238 Implementation Guide §D.5.2.1
# (Table D.1 — Mipomersen sodium). Demonstrates the new SubstanceDefinition
# nucleic-acid backbones added for FHIR-57660. Sequence chemistry is the
# published Mipomersen 20-mer antisense oligonucleotide; identifiers are
# illustrative.
<http://hl7.org/fhir/SubstanceDefinition/mipomersen> a fhir:SubstanceDefinition ;
fhir:nodeRole fhir:treeRoot ;
fhir:id [ fhir:v "mipomersen"] ; #
fhir:identifier ( [
fhir:system [
fhir:v "http://example.europa.eu/fhir/SMSId"^^xsd:anyURI ;
fhir:l <http://example.europa.eu/fhir/SMSId>
] ;
fhir:value [ fhir:v "MIPO78654S" ]
] ) ; #
fhir:status [
fhir:coding ( [
fhir:system [
fhir:v "http://hl7.org/fhir/publication-status"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/publication-status>
] ;
fhir:code [ fhir:v "active" ]
] )
] ; #
fhir:classification ( [
fhir:coding ( [
fhir:system [
fhir:v "http://example.europa.eu/fhir/SubstanceType"^^xsd:anyURI ;
fhir:l <http://example.europa.eu/fhir/SubstanceType>
] ;
fhir:code [ fhir:v "nucleic-acid" ] ;
fhir:display [ fhir:v "Nucleic Acid" ]
] )
] ) ; #
fhir:domain [
fhir:coding ( [
fhir:system [
fhir:v "http://example.europa.eu/fhir/Domain"^^xsd:anyURI ;
fhir:l <http://example.europa.eu/fhir/Domain>
] ;
fhir:code [ fhir:v "human" ] ;
fhir:display [ fhir:v "Human use" ]
] )
] ; #
fhir:description [ fhir:v "Mipomersen sodium — a synthetic second-generation 2'-methoxyethyl antisense oligonucleotide that inhibits the molecular target apolipoprotein B-100 (APOB-100). 20-mer phosphorothioate-linked sequence with 2'-MOE wing chemistry."] ; #
fhir:code ( [
fhir:code [
fhir:coding ( [
fhir:system [
fhir:v "http://example.europa.eu/fhir/Substance"^^xsd:anyURI ;
fhir:l <http://example.europa.eu/fhir/Substance>
] ;
fhir:code [ fhir:v "MIPO78654S" ]
] )
]
] ) ; #
fhir:name ( [
fhir:name [ fhir:v "Mipomersen Sodium" ] ;
fhir:preferred [ fhir:v true ] ;
fhir:language ( [
fhir:coding ( [
fhir:system [
fhir:v "urn:ietf:bcp:47"^^xsd:anyURI ;
fhir:l <urn:ietf:bcp:47>
] ;
fhir:code [ fhir:v "en" ] ;
fhir:display [ fhir:v "English" ]
] )
] ) ;
fhir:official ( [
fhir:authority [
fhir:coding ( [
fhir:system [
fhir:v "http://hl7.org/fhir/substance-name-authority"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/substance-name-authority>
] ;
fhir:code [ fhir:v "INN" ] ;
fhir:display [ fhir:v "INN" ]
] )
] ;
fhir:status [
fhir:coding ( [
fhir:system [
fhir:v "http://hl7.org/fhir/publication-status"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/publication-status>
] ;
fhir:code [ fhir:v "active" ] ;
fhir:display [ fhir:v "Active" ]
] )
]
] )
] ) ; #
fhir:nucleicAcid [
fhir:sequenceType [
fhir:coding ( [
fhir:system [
fhir:v "http://hl7.org/fhir/substance-sequence-type"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/substance-sequence-type>
] ;
fhir:code [ fhir:v "complete" ] ;
fhir:display [ fhir:v "Complete" ]
] )
] ;
fhir:numberOfSubunits [ fhir:v 1 ] ;
fhir:oligoNucleotideType [
fhir:coding ( [
fhir:system [
fhir:v "http://hl7.org/fhir/oligo-nucleotide-type"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/oligo-nucleotide-type>
] ;
fhir:code [ fhir:v "antisense" ] ;
fhir:display [ fhir:v "Antisense oligonucleotide" ]
] )
] ;
fhir:subunit ( [
fhir:subunit [ fhir:v 1 ] ;
fhir:sequence [ fhir:v "GCCUCAGTCTGCTTCGCACC" ] ;
fhir:length [ fhir:v 20 ] ;
fhir:fivePrime [
fhir:coding ( [
fhir:system [
fhir:v "http://hl7.org/fhir/nucleotide-terminus"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/nucleotide-terminus>
] ;
fhir:code [ fhir:v "G" ] ;
fhir:display [ fhir:v "Guanosine" ]
] )
] ;
fhir:threePrime [
fhir:coding ( [
fhir:system [
fhir:v "http://hl7.org/fhir/nucleotide-terminus"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/nucleotide-terminus>
] ;
fhir:code [ fhir:v "C" ] ;
fhir:display [ fhir:v "Cytidine" ]
] )
] ;
fhir:linkage ( [
fhir:connectivity [ ] ;
fhir:substance [
fhir:concept [
fhir:coding ( [
fhir:system [
fhir:v "http://example.europa.eu/fhir/LinkageSubstance"^^xsd:anyURI ;
fhir:l <http://example.europa.eu/fhir/LinkageSubstance>
] ;
fhir:code [ fhir:v "phosphorothioate" ] ;
fhir:display [ fhir:v "Phosphorothioate linkage" ]
] )
]
] ;
fhir:residueSite [ fhir:v "1-19" ]
] ) ;
fhir:sugar ( [
fhir:substance [
fhir:concept [
fhir:coding ( [
fhir:system [
fhir:v "http://example.europa.eu/fhir/SugarSubstance"^^xsd:anyURI ;
fhir:l <http://example.europa.eu/fhir/SugarSubstance>
] ;
fhir:code [ fhir:v "2-MOE" ] ;
fhir:display [ fhir:v "2'-O-(2-methoxyethyl) ribose" ]
] )
]
] ;
fhir:residueSite [ fhir:v "1-5,16-20" ]
] [
fhir:substance [
fhir:concept [
fhir:coding ( [
fhir:system [
fhir:v "http://example.europa.eu/fhir/SugarSubstance"^^xsd:anyURI ;
fhir:l <http://example.europa.eu/fhir/SugarSubstance>
] ;
fhir:code [ fhir:v "deoxyribose" ] ;
fhir:display [ fhir:v "2'-deoxyribose" ]
] )
]
] ;
fhir:residueSite [ fhir:v "6-15" ]
] )
] ) ;
fhir:gene ( [
fhir:sequenceOrigin [
fhir:coding ( [
fhir:system [
fhir:v "http://hl7.org/fhir/gene-sequence-origin"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/gene-sequence-origin>
] ;
fhir:code [ fhir:v "human" ] ;
fhir:display [ fhir:v "Human" ]
] )
] ;
fhir:gene [
fhir:concept [
fhir:coding ( [
fhir:system [
fhir:v "http://www.genenames.org"^^xsd:anyURI ;
fhir:l <http://www.genenames.org>
] ;
fhir:code [ fhir:v "APOB" ] ;
fhir:display [ fhir:v "apolipoprotein B" ]
] )
]
]
] )
] ; #
fhir:relationship ( [
fhir:substanceDefinition [
a fhir:CodeableConcept ;
fhir:coding ( [
fhir:system [
fhir:v "https://www.uniprot.org"^^xsd:anyURI ;
fhir:l <https://www.uniprot.org>
] ;
fhir:code [ fhir:v "P04114" ] ;
fhir:display [ fhir:v "apolipoprotein B-100" ]
] )
] ;
fhir:type [
fhir:coding ( [
fhir:system [
fhir:v "http://hl7.org/fhir/substance-relationship-type"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/substance-relationship-type>
] ;
fhir:code [ fhir:v "TherapeuticTarget" ] ;
fhir:display [ fhir:v "Therapeutic target" ]
] )
] ;
fhir:interaction [
fhir:coding ( [
fhir:system [
fhir:v "http://hl7.org/fhir/substance-interaction-type"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/substance-interaction-type>
] ;
fhir:code [ fhir:v "inhibition" ] ;
fhir:display [ fhir:v "Inhibition" ]
] )
]
] ) . #
# -------------------------------------------------------------------------------------
Usage note: every effort has been made to ensure that the
examples are correct and useful, but they are not a normative part
of the specification.
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