@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

# Example transcribed/adapted from ISO 11238 Implementation Guide §D.5.2.1
#     (Table D.1 — Mipomersen sodium). Demonstrates the new SubstanceDefinition
#     nucleic-acid backbones added for FHIR-57660. Sequence chemistry is the
#     published Mipomersen 20-mer antisense oligonucleotide; identifiers are
#     illustrative.

<http://hl7.org/fhir/SubstanceDefinition/mipomersen> a fhir:SubstanceDefinition ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "mipomersen"] ; # 
  fhir:identifier ( [
     fhir:system [
       fhir:v "http://example.europa.eu/fhir/SMSId"^^xsd:anyURI ;
       fhir:l <http://example.europa.eu/fhir/SMSId>
     ] ;
     fhir:value [ fhir:v "MIPO78654S" ]
  ] ) ; # 
  fhir:status [
     fhir:coding ( [
       fhir:system [
         fhir:v "http://hl7.org/fhir/publication-status"^^xsd:anyURI ;
         fhir:l <http://hl7.org/fhir/publication-status>
       ] ;
       fhir:code [ fhir:v "active" ]
     ] )
  ] ; # 
  fhir:classification ( [
     fhir:coding ( [
       fhir:system [
         fhir:v "http://example.europa.eu/fhir/SubstanceType"^^xsd:anyURI ;
         fhir:l <http://example.europa.eu/fhir/SubstanceType>
       ] ;
       fhir:code [ fhir:v "nucleic-acid" ] ;
       fhir:display [ fhir:v "Nucleic Acid" ]
     ] )
  ] ) ; # 
  fhir:domain [
     fhir:coding ( [
       fhir:system [
         fhir:v "http://example.europa.eu/fhir/Domain"^^xsd:anyURI ;
         fhir:l <http://example.europa.eu/fhir/Domain>
       ] ;
       fhir:code [ fhir:v "human" ] ;
       fhir:display [ fhir:v "Human use" ]
     ] )
  ] ; # 
  fhir:description [ fhir:v "Mipomersen sodium — a synthetic second-generation 2'-methoxyethyl antisense oligonucleotide that inhibits the molecular target apolipoprotein B-100 (APOB-100). 20-mer phosphorothioate-linked sequence with 2'-MOE wing chemistry."] ; # 
  fhir:code ( [
     fhir:code [
       fhir:coding ( [
         fhir:system [
           fhir:v "http://example.europa.eu/fhir/Substance"^^xsd:anyURI ;
           fhir:l <http://example.europa.eu/fhir/Substance>
         ] ;
         fhir:code [ fhir:v "MIPO78654S" ]
       ] )
     ]
  ] ) ; # 
  fhir:name ( [
     fhir:name [ fhir:v "Mipomersen Sodium" ] ;
     fhir:preferred [ fhir:v true ] ;
     fhir:language ( [
       fhir:coding ( [
         fhir:system [
           fhir:v "urn:ietf:bcp:47"^^xsd:anyURI ;
           fhir:l <urn:ietf:bcp:47>
         ] ;
         fhir:code [ fhir:v "en" ] ;
         fhir:display [ fhir:v "English" ]
       ] )
     ] ) ;
     fhir:official ( [
       fhir:authority [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://hl7.org/fhir/substance-name-authority"^^xsd:anyURI ;
             fhir:l <http://hl7.org/fhir/substance-name-authority>
           ] ;
           fhir:code [ fhir:v "INN" ] ;
           fhir:display [ fhir:v "INN" ]
         ] )
       ] ;
       fhir:status [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://hl7.org/fhir/publication-status"^^xsd:anyURI ;
             fhir:l <http://hl7.org/fhir/publication-status>
           ] ;
           fhir:code [ fhir:v "active" ] ;
           fhir:display [ fhir:v "Active" ]
         ] )
       ]
     ] )
  ] ) ; # 
  fhir:nucleicAcid [
     fhir:sequenceType [
       fhir:coding ( [
         fhir:system [
           fhir:v "http://hl7.org/fhir/substance-sequence-type"^^xsd:anyURI ;
           fhir:l <http://hl7.org/fhir/substance-sequence-type>
         ] ;
         fhir:code [ fhir:v "complete" ] ;
         fhir:display [ fhir:v "Complete" ]
       ] )
     ] ;
     fhir:numberOfSubunits [ fhir:v 1 ] ;
     fhir:oligoNucleotideType [
       fhir:coding ( [
         fhir:system [
           fhir:v "http://hl7.org/fhir/oligo-nucleotide-type"^^xsd:anyURI ;
           fhir:l <http://hl7.org/fhir/oligo-nucleotide-type>
         ] ;
         fhir:code [ fhir:v "antisense" ] ;
         fhir:display [ fhir:v "Antisense oligonucleotide" ]
       ] )
     ] ;
     fhir:subunit ( [
       fhir:subunit [ fhir:v 1 ] ;
       fhir:sequence [ fhir:v "GCCUCAGTCTGCTTCGCACC" ] ;
       fhir:length [ fhir:v 20 ] ;
       fhir:fivePrime [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://hl7.org/fhir/nucleotide-terminus"^^xsd:anyURI ;
             fhir:l <http://hl7.org/fhir/nucleotide-terminus>
           ] ;
           fhir:code [ fhir:v "G" ] ;
           fhir:display [ fhir:v "Guanosine" ]
         ] )
       ] ;
       fhir:threePrime [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://hl7.org/fhir/nucleotide-terminus"^^xsd:anyURI ;
             fhir:l <http://hl7.org/fhir/nucleotide-terminus>
           ] ;
           fhir:code [ fhir:v "C" ] ;
           fhir:display [ fhir:v "Cytidine" ]
         ] )
       ] ;
       fhir:linkage ( [
         fhir:connectivity [ ] ;
         fhir:substance [
           fhir:concept [
             fhir:coding ( [
               fhir:system [
                 fhir:v "http://example.europa.eu/fhir/LinkageSubstance"^^xsd:anyURI ;
                 fhir:l <http://example.europa.eu/fhir/LinkageSubstance>
               ] ;
               fhir:code [ fhir:v "phosphorothioate" ] ;
               fhir:display [ fhir:v "Phosphorothioate linkage" ]
             ] )
           ]
         ] ;
         fhir:residueSite [ fhir:v "1-19" ]
       ] ) ;
       fhir:sugar ( [
         fhir:substance [
           fhir:concept [
             fhir:coding ( [
               fhir:system [
                 fhir:v "http://example.europa.eu/fhir/SugarSubstance"^^xsd:anyURI ;
                 fhir:l <http://example.europa.eu/fhir/SugarSubstance>
               ] ;
               fhir:code [ fhir:v "2-MOE" ] ;
               fhir:display [ fhir:v "2'-O-(2-methoxyethyl) ribose" ]
             ] )
           ]
         ] ;
         fhir:residueSite [ fhir:v "1-5,16-20" ]
       ] [
         fhir:substance [
           fhir:concept [
             fhir:coding ( [
               fhir:system [
                 fhir:v "http://example.europa.eu/fhir/SugarSubstance"^^xsd:anyURI ;
                 fhir:l <http://example.europa.eu/fhir/SugarSubstance>
               ] ;
               fhir:code [ fhir:v "deoxyribose" ] ;
               fhir:display [ fhir:v "2'-deoxyribose" ]
             ] )
           ]
         ] ;
         fhir:residueSite [ fhir:v "6-15" ]
       ] )
     ] ) ;
     fhir:gene ( [
       fhir:sequenceOrigin [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://hl7.org/fhir/gene-sequence-origin"^^xsd:anyURI ;
             fhir:l <http://hl7.org/fhir/gene-sequence-origin>
           ] ;
           fhir:code [ fhir:v "human" ] ;
           fhir:display [ fhir:v "Human" ]
         ] )
       ] ;
       fhir:gene [
         fhir:concept [
           fhir:coding ( [
             fhir:system [
               fhir:v "http://www.genenames.org"^^xsd:anyURI ;
               fhir:l <http://www.genenames.org>
             ] ;
             fhir:code [ fhir:v "APOB" ] ;
             fhir:display [ fhir:v "apolipoprotein B" ]
           ] )
         ]
       ]
     ] )
  ] ; # 
  fhir:relationship ( [
     fhir:substanceDefinition [
       a fhir:CodeableConcept ;
       fhir:coding ( [
         fhir:system [
           fhir:v "https://www.uniprot.org"^^xsd:anyURI ;
           fhir:l <https://www.uniprot.org>
         ] ;
         fhir:code [ fhir:v "P04114" ] ;
         fhir:display [ fhir:v "apolipoprotein B-100" ]
       ] )
     ] ;
     fhir:type [
       fhir:coding ( [
         fhir:system [
           fhir:v "http://hl7.org/fhir/substance-relationship-type"^^xsd:anyURI ;
           fhir:l <http://hl7.org/fhir/substance-relationship-type>
         ] ;
         fhir:code [ fhir:v "TherapeuticTarget" ] ;
         fhir:display [ fhir:v "Therapeutic target" ]
       ] )
     ] ;
     fhir:interaction [
       fhir:coding ( [
         fhir:system [
           fhir:v "http://hl7.org/fhir/substance-interaction-type"^^xsd:anyURI ;
           fhir:l <http://hl7.org/fhir/substance-interaction-type>
         ] ;
         fhir:code [ fhir:v "inhibition" ] ;
         fhir:display [ fhir:v "Inhibition" ]
       ] )
     ]
  ] ) . # 

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