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Example SubstanceDefinition/ponatinib-hcl (Turtle)
Raw Turtle (+ also see Turtle/RDF Format Specification)
Chemical substance: Ponatinib hydrochloride — small-molecule tyrosine kinase inhibitor targeting BCR-ABL
@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
# - resource -------------------------------------------------------------------
# Example: Ponatinib hydrochloride — a tyrosine kinase inhibitor used for
# chronic myeloid leukemia. Chemical substance from ISO 11238 IG examples.
# Demonstrates SubstanceDefinition for a small-molecule chemical with
# moiety (the salt: HCl) and target relationship (BCR-ABL kinase).
<http://hl7.org/fhir/SubstanceDefinition/ponatinib-hcl> a fhir:SubstanceDefinition ;
fhir:nodeRole fhir:treeRoot ;
fhir:id [ fhir:v "ponatinib-hcl"] ; #
fhir:identifier ( [
fhir:system [
fhir:v "http://example.europa.eu/fhir/SMSId"^^xsd:anyURI ;
fhir:l <http://example.europa.eu/fhir/SMSId>
] ;
fhir:value [ fhir:v "PONA4321C" ]
] ) ; #
fhir:status [
fhir:coding ( [
fhir:system [
fhir:v "http://hl7.org/fhir/publication-status"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/publication-status>
] ;
fhir:code [ fhir:v "active" ] ;
fhir:display [ fhir:v "Active" ]
] )
] ; #
fhir:classification ( [
fhir:coding ( [
fhir:system [
fhir:v "http://example.europa.eu/fhir/SubstanceType"^^xsd:anyURI ;
fhir:l <http://example.europa.eu/fhir/SubstanceType>
] ;
fhir:code [ fhir:v "chemical" ] ;
fhir:display [ fhir:v "Chemical" ]
] )
] ) ; #
fhir:domain [
fhir:coding ( [
fhir:system [
fhir:v "http://example.europa.eu/fhir/Domain"^^xsd:anyURI ;
fhir:l <http://example.europa.eu/fhir/Domain>
] ;
fhir:code [ fhir:v "human" ] ;
fhir:display [ fhir:v "Human use" ]
] )
] ; #
fhir:description [ fhir:v "Ponatinib hydrochloride — a small-molecule tyrosine kinase inhibitor (TKI) used in the treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). Hydrochloride salt of ponatinib."] ; #
fhir:code ( [
fhir:code [
fhir:coding ( [
fhir:system [
fhir:v "http://example.europa.eu/fhir/Substance"^^xsd:anyURI ;
fhir:l <http://example.europa.eu/fhir/Substance>
] ;
fhir:code [ fhir:v "PONA4321C" ]
] )
]
] ) ; #
fhir:name ( [
fhir:name [ fhir:v "Ponatinib Hydrochloride" ] ;
fhir:preferred [ fhir:v true ] ;
fhir:language ( [
fhir:coding ( [
fhir:system [
fhir:v "urn:ietf:bcp:47"^^xsd:anyURI ;
fhir:l <urn:ietf:bcp:47>
] ;
fhir:code [ fhir:v "en" ] ;
fhir:display [ fhir:v "English" ]
] )
] ) ;
fhir:official ( [
fhir:authority [
fhir:coding ( [
fhir:system [
fhir:v "http://hl7.org/fhir/substance-name-authority"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/substance-name-authority>
] ;
fhir:code [ fhir:v "USAN" ] ;
fhir:display [ fhir:v "USAN" ]
] )
] ;
fhir:status [
fhir:coding ( [
fhir:system [
fhir:v "http://hl7.org/fhir/publication-status"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/publication-status>
] ;
fhir:code [ fhir:v "active" ] ;
fhir:display [ fhir:v "Active" ]
] )
]
] )
] ) ; #
fhir:molecularWeight ( [
fhir:type [
fhir:coding ( [
fhir:system [
fhir:v "http://example.europa.eu/fhir/WeightType"^^xsd:anyURI ;
fhir:l <http://example.europa.eu/fhir/WeightType>
] ;
fhir:code [ fhir:v "exact" ] ;
fhir:display [ fhir:v "Exact" ]
] )
] ;
fhir:amount [
fhir:value [ fhir:v 569.04 ] ;
fhir:unit [ fhir:v "g/mol" ] ;
fhir:system [
fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ;
fhir:l <http://unitsofmeasure.org>
] ;
fhir:code [ fhir:v "g/mol" ]
]
] ) ; #
fhir:moiety ( [
fhir:role [
fhir:coding ( [
fhir:system [
fhir:v "http://example.europa.eu/fhir/MoietyRole"^^xsd:anyURI ;
fhir:l <http://example.europa.eu/fhir/MoietyRole>
] ;
fhir:code [ fhir:v "active-moiety" ] ;
fhir:display [ fhir:v "Active moiety" ]
] )
] ;
fhir:name [ fhir:v "Ponatinib" ] ;
fhir:molecularFormula [ fhir:v "C29H27F3N6O" ]
] [
fhir:role [
fhir:coding ( [
fhir:system [
fhir:v "http://example.europa.eu/fhir/MoietyRole"^^xsd:anyURI ;
fhir:l <http://example.europa.eu/fhir/MoietyRole>
] ;
fhir:code [ fhir:v "counter-ion" ] ;
fhir:display [ fhir:v "Counter-ion (salt)" ]
] )
] ;
fhir:name [ fhir:v "Hydrochloride" ] ;
fhir:molecularFormula [ fhir:v "HCl" ]
] ) ; #
fhir:relationship ( [
fhir:substanceDefinition [
a fhir:CodeableConcept ;
fhir:coding ( [
fhir:system [
fhir:v "https://www.uniprot.org"^^xsd:anyURI ;
fhir:l <https://www.uniprot.org>
] ;
fhir:code [ fhir:v "A9UF07" ] ;
fhir:display [ fhir:v "BCR-ABL1 fusion kinase" ]
] )
] ;
fhir:type [
fhir:coding ( [
fhir:system [
fhir:v "http://hl7.org/fhir/substance-relationship-type"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/substance-relationship-type>
] ;
fhir:code [ fhir:v "TherapeuticTarget" ] ;
fhir:display [ fhir:v "Therapeutic target" ]
] )
] ;
fhir:interaction [
fhir:coding ( [
fhir:system [
fhir:v "http://hl7.org/fhir/substance-interaction-type"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/substance-interaction-type>
] ;
fhir:code [ fhir:v "inhibition" ] ;
fhir:display [ fhir:v "Inhibition" ]
] )
] ;
fhir:measurementType [
fhir:coding ( [
fhir:system [
fhir:v "http://hl7.org/fhir/substance-measurement-type"^^xsd:anyURI ;
fhir:l <http://hl7.org/fhir/substance-measurement-type>
] ;
fhir:code [ fhir:v "ic50" ] ;
fhir:display [ fhir:v "IC50" ]
] )
] ;
fhir:amount [
a fhir:Quantity ;
fhir:value [ fhir:v 0.37 ] ;
fhir:unit [ fhir:v "nM" ] ;
fhir:system [
fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ;
fhir:l <http://unitsofmeasure.org>
] ;
fhir:code [ fhir:v "nmol/L" ]
]
] ) . #
# -------------------------------------------------------------------------------------
Usage note: every effort has been made to ensure that the
examples are correct and useful, but they are not a normative part
of the specification.
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