Chemical substance: Ponatinib hydrochloride — small-molecule tyrosine kinase inhibitor targeting BCR-ABL

{
  "resourceType" : "SubstanceDefinition",
  "id" : "ponatinib-hcl",
  "identifier" : [{
    "system" : "http://example.europa.eu/fhir/SMSId",
    "value" : "PONA4321C"
  }],
  "status" : {
    "coding" : [{
      "system" : "http://hl7.org/fhir/publication-status",
      "code" : "active",
      "display" : "Active"
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      "code" : "chemical",
      "display" : "Chemical"
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  "domain" : {
    "coding" : [{
      "system" : "http://example.europa.eu/fhir/Domain",
      "code" : "human",
      "display" : "Human use"
    }]
  },
  "description" : "Ponatinib hydrochloride — a small-molecule tyrosine kinase inhibitor (TKI) used in the treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). Hydrochloride salt of ponatinib.",
  "code" : [{
    "code" : {
      "coding" : [{
        "system" : "http://example.europa.eu/fhir/Substance",
        "code" : "PONA4321C"
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    }
  }],
  "name" : [{
    "name" : "Ponatinib Hydrochloride",
    "preferred" : true,
    "language" : [{
      "coding" : [{
        "system" : "urn:ietf:bcp:47",
        "code" : "en",
        "display" : "English"
      }]
    }],
    "official" : [{
      "authority" : {
        "coding" : [{
          "system" : "http://hl7.org/fhir/substance-name-authority",
          "code" : "USAN",
          "display" : "USAN"
        }]
      },
      "status" : {
        "coding" : [{
          "system" : "http://hl7.org/fhir/publication-status",
          "code" : "active",
          "display" : "Active"
        }]
      }
    }]
  }],
  "molecularWeight" : [{
    "type" : {
      "coding" : [{
        "system" : "http://example.europa.eu/fhir/WeightType",
        "code" : "exact",
        "display" : "Exact"
      }]
    },
    "amount" : {
      "value" : 569.04,
      "unit" : "g/mol",
      "system" : "http://unitsofmeasure.org",
      "code" : "g/mol"
    }
  }],
  "moiety" : [{
    "role" : {
      "coding" : [{
        "system" : "http://example.europa.eu/fhir/MoietyRole",
        "code" : "active-moiety",
        "display" : "Active moiety"
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    },
    "name" : "Ponatinib",
    "molecularFormula" : "C29H27F3N6O"
  },
  {
    "role" : {
      "coding" : [{
        "system" : "http://example.europa.eu/fhir/MoietyRole",
        "code" : "counter-ion",
        "display" : "Counter-ion (salt)"
      }]
    },
    "name" : "Hydrochloride",
    "molecularFormula" : "HCl"
  }],
  "relationship" : [{
    "substanceDefinitionCodeableConcept" : {
      "coding" : [{
        "system" : "https://www.uniprot.org",
        "code" : "A9UF07",
        "display" : "BCR-ABL1 fusion kinase"
      }]
    },
    "type" : {
      "coding" : [{
        "system" : "http://hl7.org/fhir/substance-relationship-type",
        "code" : "TherapeuticTarget",
        "display" : "Therapeutic target"
      }]
    },
    "interaction" : {
      "coding" : [{
        "system" : "http://hl7.org/fhir/substance-interaction-type",
        "code" : "inhibition",
        "display" : "Inhibition"
      }]
    },
    "measurementType" : {
      "coding" : [{
        "system" : "http://hl7.org/fhir/substance-measurement-type",
        "code" : "ic50",
        "display" : "IC50"
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    },
    "amountQuantity" : {
      "value" : 0.37,
      "unit" : "nM",
      "system" : "http://unitsofmeasure.org",
      "code" : "nmol/L"
    }
  }]
}